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Conserved domains on  [gi|1154784169|ref|WP_078700266|]
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molybdopterin-binding protein [Aeromicrobium choanae]

Protein Classification

TOBE domain-containing protein( domain architecture ID 10007583)

TOBE (Transport-associated OB) domain-containing protein is also known as molybdopterin-binding protein that may be involved in the recognition of small ligands such as molybdenum and sulfate

CATH:  2.40.50.100
Gene Ontology:  GO:0015689
PubMed:  8458342
SCOP:  4000175

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MopI COG3585
Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];
1-113 1.41e-15

Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];


:

Pssm-ID: 442804 [Multi-domain]  Cd Length: 141  Bit Score: 68.18  E-value: 1.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154784169   1 MSQVRVADAADFLGVSTDTVRRLIASGRLAAGKDGSGRTVVDGRGLADYVRVEGRSAADPTAVGR-SARNRFVGIVTEVL 79
Cdd:COG3585     9 FGGVVSIIAGGVVNEVVLLLLGGGTIIAAITTASSAELLGLVGGKEVAALKKASVVILATDDAMKlSARNQLKGTVTRIE 88

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1154784169  80 SDRVMSQVELQCGA-HRVVSLISTESVRELGLEPG 113
Cdd:COG3585    89 RGAVNSEVVLDLGGgTTLTAVITNESVEELGLKEG 123
 
Name Accession Description Interval E-value
MopI COG3585
Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];
1-113 1.41e-15

Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];


Pssm-ID: 442804 [Multi-domain]  Cd Length: 141  Bit Score: 68.18  E-value: 1.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154784169   1 MSQVRVADAADFLGVSTDTVRRLIASGRLAAGKDGSGRTVVDGRGLADYVRVEGRSAADPTAVGR-SARNRFVGIVTEVL 79
Cdd:COG3585     9 FGGVVSIIAGGVVNEVVLLLLGGGTIIAAITTASSAELLGLVGGKEVAALKKASVVILATDDAMKlSARNQLKGTVTRIE 88

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1154784169  80 SDRVMSQVELQCGA-HRVVSLISTESVRELGLEPG 113
Cdd:COG3585    89 RGAVNSEVVLDLGGgTTLTAVITNESVEELGLKEG 123
HTH_17 pfam12728
Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.
 6-51 7.79e-06

Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.


Pssm-ID: 463684 [Multi-domain]  Cd Length: 51  Bit Score: 40.52  E-value: 7.79e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1154784169   6 VADAADFLGVSTDTVRRLIASGRLAAGKDGsGRTVVDGRGLADYVR 51
Cdd:pfam12728   4 VEEAAELLGVSRRTVYRLIRSGELPAAKIG-RRWRIRKSDLEEWLE 48
Mop TIGR00638
molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin ...
 66-113 4.23e-05

molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin binding proteins of about 70 amino acids in Clostridium pasteurianum, as a tandemly-repeated domain C-terminal to an unrelated domain in ModE, a molybdate transport gene repressor of E. coli, and in single or tandemly paired domains in several related proteins. [Transport and binding proteins, Anions]


Pssm-ID: 273189 [Multi-domain]  Cd Length: 69  Bit Score: 39.26  E-value: 4.23e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1154784169  66 SARNRFVGIVTEVLSDRVMSQVELQC-GAHRVVSLISTESVRELGLEPG 113
Cdd:TIGR00638   4 SARNQLKGKVVAIEDGDVNAEVDLLLgGGTKLTAVITLESVAELGLKPG 52
HTH_MerR-trunc cd04762
Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Proteins in this family ...
 4-47 5.47e-05

Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Proteins in this family mostly have a truncated helix-turn-helix (HTH) MerR-like domain. They lack a portion of the C-terminal region, called Wing 2 and the long dimerization helix that is typically present in MerR-like proteins. These truncated domains are found in response regulator receiver (REC) domain proteins (i.e., CheY), cytosine-C5 specific DNA methylases, IS607 transposase-like proteins, and RacA, a bacterial protein that anchors chromosomes to cell poles.


Pssm-ID: 133390 [Multi-domain]  Cd Length: 49  Bit Score: 38.33  E-value: 5.47e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1154784169   4 VRVADAADFLGVSTDTVRRLIASGRLAAGKDGSGRTVVDGRGLA 47
Cdd:cd04762     1 LTTKEAAELLGVSPSTLRRWVKEGKLKAIRTPGGHRRFPEEDLE 44
 
Name Accession Description Interval E-value
MopI COG3585
Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];
1-113 1.41e-15

Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];


Pssm-ID: 442804 [Multi-domain]  Cd Length: 141  Bit Score: 68.18  E-value: 1.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154784169   1 MSQVRVADAADFLGVSTDTVRRLIASGRLAAGKDGSGRTVVDGRGLADYVRVEGRSAADPTAVGR-SARNRFVGIVTEVL 79
Cdd:COG3585     9 FGGVVSIIAGGVVNEVVLLLLGGGTIIAAITTASSAELLGLVGGKEVAALKKASVVILATDDAMKlSARNQLKGTVTRIE 88

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1154784169  80 SDRVMSQVELQCGA-HRVVSLISTESVRELGLEPG 113
Cdd:COG3585    89 RGAVNSEVVLDLGGgTTLTAVITNESVEELGLKEG 123
HTH_17 pfam12728
Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.
 6-51 7.79e-06

Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.


Pssm-ID: 463684 [Multi-domain]  Cd Length: 51  Bit Score: 40.52  E-value: 7.79e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1154784169   6 VADAADFLGVSTDTVRRLIASGRLAAGKDGsGRTVVDGRGLADYVR 51
Cdd:pfam12728   4 VEEAAELLGVSRRTVYRLIRSGELPAAKIG-RRWRIRKSDLEEWLE 48
Mop TIGR00638
molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin ...
 66-113 4.23e-05

molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin binding proteins of about 70 amino acids in Clostridium pasteurianum, as a tandemly-repeated domain C-terminal to an unrelated domain in ModE, a molybdate transport gene repressor of E. coli, and in single or tandemly paired domains in several related proteins. [Transport and binding proteins, Anions]


Pssm-ID: 273189 [Multi-domain]  Cd Length: 69  Bit Score: 39.26  E-value: 4.23e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1154784169  66 SARNRFVGIVTEVLSDRVMSQVELQC-GAHRVVSLISTESVRELGLEPG 113
Cdd:TIGR00638   4 SARNQLKGKVVAIEDGDVNAEVDLLLgGGTKLTAVITLESVAELGLKPG 52
HTH_MerR-trunc cd04762
Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Proteins in this family ...
 4-47 5.47e-05

Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Proteins in this family mostly have a truncated helix-turn-helix (HTH) MerR-like domain. They lack a portion of the C-terminal region, called Wing 2 and the long dimerization helix that is typically present in MerR-like proteins. These truncated domains are found in response regulator receiver (REC) domain proteins (i.e., CheY), cytosine-C5 specific DNA methylases, IS607 transposase-like proteins, and RacA, a bacterial protein that anchors chromosomes to cell poles.


Pssm-ID: 133390 [Multi-domain]  Cd Length: 49  Bit Score: 38.33  E-value: 5.47e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1154784169   4 VRVADAADFLGVSTDTVRRLIASGRLAAGKDGSGRTVVDGRGLA 47
Cdd:cd04762     1 LTTKEAAELLGVSPSTLRRWVKEGKLKAIRTPGGHRRFPEEDLE 44
excise TIGR01764
DNA binding domain, excisionase family; An excisionase, or Xis protein, is a small protein ...
 5-38 1.41e-04

DNA binding domain, excisionase family; An excisionase, or Xis protein, is a small protein that binds and promotes excisive recombination; it is not enzymatically active. This model represents a number of putative excisionases and related proteins from temperate phage, plasmids, and transposons, as well as DNA binding domains of other proteins, such as a DNA modification methylase. This model identifies mostly small proteins and N-terminal regions of large proteins, but some proteins appear to have two copies. This domain appears similar, in both sequence and predicted secondary structure (PSIPRED) to the MerR family of transcriptional regulators (pfam00376). [Unknown function, General]


Pssm-ID: 200128  Cd Length: 49  Bit Score: 37.20  E-value: 1.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1154784169   5 RVADAADFLGVSTDTVRRLIASGRLAAGKDGSGR 38
Cdd:TIGR01764   3 TVEEAAEYLGVSKSTVYRLIEEGELPAYRVGRHY 36
TOBE pfam03459
TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the ...
 67-113 1.78e-03

TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum and sulfate. Found in ABC transporters immediately after the ATPase domain.


Pssm-ID: 427310 [Multi-domain]  Cd Length: 60  Bit Score: 34.56  E-value: 1.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1154784169  67 ARNRFVGIVTEVLSDRVMSQVELQCGAH-RVVSLISTESVRELGLEPG 113
Cdd:pfam03459   1 ARNQLPGTVTVIEPLGSEVEVRVDLGGGlTLTARITRDSAEELGLAPG 48
COG2452 COG2452
Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];
4-80 2.53e-03

Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];


Pssm-ID: 441988 [Multi-domain]  Cd Length: 178  Bit Score: 36.12  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154784169   4 VRVADAADFLGVSTDTVRRLIASGRLAAGKDGSGRTVVD-------GRGLADYVRVEGRSAAD--PTAVGR-----SARN 69
Cdd:COG2452     1 LTPGEAAELLGVSPKTLRRWEKEGKLPAIRTPGGHRRYPeseverlERRTVIYARVSSADQKDdlERQVERleeyaTAKG 80

                          90
                  ....*....|.
gi 1154784169  70 RFVGIVTEVLS 80
Cdd:COG2452    81 YQDEVIKDVGS 91
AlpA COG3311
DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];
4-29 4.00e-03

DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];


Pssm-ID: 442540 [Multi-domain]  Cd Length: 64  Bit Score: 33.75  E-value: 4.00e-03
                          10        20
                  ....*....|....*....|....*.
gi 1154784169   4 VRVADAADFLGVSTDTVRRLIASGRL 29
Cdd:COG3311     9 LRLKEVAELLGVSRSTIYRLIKKGEF 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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