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Conserved domains on  [gi|1149978421|ref|WP_077905100|]
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GyrI-like domain-containing protein [Salmonella enterica]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15121 super family cl33090
MDR efflux pump AcrAB transcriptional activator RobA;
2-284 7.60e-40

MDR efflux pump AcrAB transcriptional activator RobA;


The actual alignment was detected with superfamily member PRK15121:

Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 140.14  E-value: 7.60e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421   2 MMKRAIIVSVLEQIEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRM 81
Cdd:PRK15121    1 MDQAGIIRDLLIWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421  82 GFDSVQSYSREFKKTFGVNPNNYRKADFWDLGNLRPPYWLDCDEHYQFEICQLTSKEIFGFQTSH-----QIA------- 149
Cdd:PRK15121   81 RFDSQQTFTRAFKKQFAQTPALYRRSPEWSAFGIRPPIRLGEFTLPEHEFVTLPETPLVGVTQSYscsleQISdfrhemr 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421 150 ----------TNDLPkkasPIkwkiihetlrtwgenVYCLSSFKPDNTKD--QVIAVSSFFGMEH--NSVDGGKipmSRV 215
Cdd:PRK15121  161 vqfwrdflgnAPTIP----PV---------------LYGLHETRPSQEKDdeQEVFYTTALEPDQadGYVQTGH---PVM 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1149978421 216 IKCGKYAKFHFVGHKEQYQQFSNTIYMCILPKLNLIRREGEDIEYFHLASVQKQQNNESIVDLYYYIPV 284
Cdd:PRK15121  219 LQGGEYVMFTYEGLGTGLQEFILTVYGTCMPMLNLTRRKGQDIERYYPAEDAKAGDRPINLRCEYLIPI 287
 
Name Accession Description Interval E-value
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
2-284 7.60e-40

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 140.14  E-value: 7.60e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421   2 MMKRAIIVSVLEQIEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRM 81
Cdd:PRK15121    1 MDQAGIIRDLLIWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421  82 GFDSVQSYSREFKKTFGVNPNNYRKADFWDLGNLRPPYWLDCDEHYQFEICQLTSKEIFGFQTSH-----QIA------- 149
Cdd:PRK15121   81 RFDSQQTFTRAFKKQFAQTPALYRRSPEWSAFGIRPPIRLGEFTLPEHEFVTLPETPLVGVTQSYscsleQISdfrhemr 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421 150 ----------TNDLPkkasPIkwkiihetlrtwgenVYCLSSFKPDNTKD--QVIAVSSFFGMEH--NSVDGGKipmSRV 215
Cdd:PRK15121  161 vqfwrdflgnAPTIP----PV---------------LYGLHETRPSQEKDdeQEVFYTTALEPDQadGYVQTGH---PVM 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1149978421 216 IKCGKYAKFHFVGHKEQYQQFSNTIYMCILPKLNLIRREGEDIEYFHLASVQKQQNNESIVDLYYYIPV 284
Cdd:PRK15121  219 LQGGEYVMFTYEGLGTGLQEFILTVYGTCMPMLNLTRRKGQDIERYYPAEDAKAGDRPINLRCEYLIPI 287
GyrI-like pfam06445
GyrI-like small molecule binding domain; This family contains the small molecule binding ...
 128-284 1.35e-24

GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.


Pssm-ID: 428947  Cd Length: 153  Bit Score: 96.32  E-value: 1.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421 128 QFEICQLTSKEIFGFQTSHQIATNDLPKKASPIKWKIIHETLRTWGENVYCLSSFKPDNTKDQVIAVSSFFGMEHNSVDG 207
Cdd:pfam06445   1 EVEIVELPAFRVAGLRHRGPYNEEGIGALWEELCAWASENGLSPAPSPLIGVSYDDPEVTEDEELRYDAGVAVPIPVEGP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1149978421 208 GKIpMSRVIKCGKYAKFHFVGHKEQYQQFSNTIYMCILPKLNLIRREGEDIEYFHLASvqkQQNNESIVDLYYYIPV 284
Cdd:pfam06445  81 EGV-EELELPGGEYAVFRHKGPYDDLQETYAKIYGEWLPESGYERRDGPSFEIYLNDP---REVPEEELKTEIYIPV 153
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
12-107 2.80e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 96.00  E-value: 2.80e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421  12 LEQIEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRMGFDSVQSYSR 91
Cdd:COG2207   158 LLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSR 237

                          90
                  ....*....|....*.
gi 1149978421  92 EFKKTFGVNPNNYRKA 107
Cdd:COG2207   238 AFKKRFGVTPSEYRKR 253
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
22-105 6.17e-23

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 89.92  E-value: 6.17e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421   22 RIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRMGFDSVQSYSREFKKTFGVNP 101
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 1149978421  102 NNYR 105
Cdd:smart00342  81 SEYR 84
 
Name Accession Description Interval E-value
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
2-284 7.60e-40

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 140.14  E-value: 7.60e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421   2 MMKRAIIVSVLEQIEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRM 81
Cdd:PRK15121    1 MDQAGIIRDLLIWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421  82 GFDSVQSYSREFKKTFGVNPNNYRKADFWDLGNLRPPYWLDCDEHYQFEICQLTSKEIFGFQTSH-----QIA------- 149
Cdd:PRK15121   81 RFDSQQTFTRAFKKQFAQTPALYRRSPEWSAFGIRPPIRLGEFTLPEHEFVTLPETPLVGVTQSYscsleQISdfrhemr 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421 150 ----------TNDLPkkasPIkwkiihetlrtwgenVYCLSSFKPDNTKD--QVIAVSSFFGMEH--NSVDGGKipmSRV 215
Cdd:PRK15121  161 vqfwrdflgnAPTIP----PV---------------LYGLHETRPSQEKDdeQEVFYTTALEPDQadGYVQTGH---PVM 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1149978421 216 IKCGKYAKFHFVGHKEQYQQFSNTIYMCILPKLNLIRREGEDIEYFHLASVQKQQNNESIVDLYYYIPV 284
Cdd:PRK15121  219 LQGGEYVMFTYEGLGTGLQEFILTVYGTCMPMLNLTRRKGQDIERYYPAEDAKAGDRPINLRCEYLIPI 287
GyrI-like pfam06445
GyrI-like small molecule binding domain; This family contains the small molecule binding ...
 128-284 1.35e-24

GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.


Pssm-ID: 428947  Cd Length: 153  Bit Score: 96.32  E-value: 1.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421 128 QFEICQLTSKEIFGFQTSHQIATNDLPKKASPIKWKIIHETLRTWGENVYCLSSFKPDNTKDQVIAVSSFFGMEHNSVDG 207
Cdd:pfam06445   1 EVEIVELPAFRVAGLRHRGPYNEEGIGALWEELCAWASENGLSPAPSPLIGVSYDDPEVTEDEELRYDAGVAVPIPVEGP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1149978421 208 GKIpMSRVIKCGKYAKFHFVGHKEQYQQFSNTIYMCILPKLNLIRREGEDIEYFHLASvqkQQNNESIVDLYYYIPV 284
Cdd:pfam06445  81 EGV-EELELPGGEYAVFRHKGPYDDLQETYAKIYGEWLPESGYERRDGPSFEIYLNDP---REVPEEELKTEIYIPV 153
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
12-107 2.80e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 96.00  E-value: 2.80e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421  12 LEQIEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRMGFDSVQSYSR 91
Cdd:COG2207   158 LLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSR 237

                          90
                  ....*....|....*.
gi 1149978421  92 EFKKTFGVNPNNYRKA 107
Cdd:COG2207   238 AFKKRFGVTPSEYRKR 253
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
22-105 6.17e-23

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 89.92  E-value: 6.17e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421   22 RIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRMGFDSVQSYSREFKKTFGVNP 101
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 1149978421  102 NNYR 105
Cdd:smart00342  81 SEYR 84
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
2-107 1.66e-20

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 84.21  E-value: 1.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421   2 MMKRAIIVSVLEQIEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRM 81
Cdd:PRK10219    1 MSHQKIIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDL 80

                          90       100
                  ....*....|....*....|....*.
gi 1149978421  82 GFDSVQSYSREFKKTFGVNPNNYRKA 107
Cdd:PRK10219   81 GYVSQQTFSRVFRRQFDRTPSDYRHR 106
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
8-105 2.69e-20

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 84.38  E-value: 2.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421   8 IVSVLEQIEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRMGFDSVQ 87
Cdd:PRK11511   11 IHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQ 90

                          90
                  ....*....|....*...
gi 1149978421  88 SYSREFKKTFGVNPNNYR 105
Cdd:PRK11511   91 TLTRTFKNYFDVPPHKYR 108
HTH_18 pfam12833
Helix-turn-helix domain;
31-107 3.66e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 82.25  E-value: 3.66e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1149978421  31 ITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLL-KLTSQSVTDIAFRMGFDSVQSYSREFKKTFGVNPNNYRKA 107
Cdd:pfam12833   4 ALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRRR 81
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 8-107 1.89e-18

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 83.28  E-value: 1.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421   8 IVSVLEQIEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRMGFDSVQ 87
Cdd:COG4977   212 LARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSAS 291

                          90       100
                  ....*....|....*....|
gi 1149978421  88 SYSREFKKTFGVNPNNYRKA 107
Cdd:COG4977   292 HFRRAFRRRFGVSPSAYRRR 311
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 11-106 2.37e-15

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 74.68  E-value: 2.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421  11 VLEQIEKNL-EERIDIEKLVVITGYSRRSLQDFFKEKcGVSIGKYIRQRKLSRSATLLK--LTSQSVTDIAFRMGFDSVQ 87
Cdd:PRK09685  202 VVALIDQSIqEEILRPEWIAGELGISVRSLYRLFAEQ-GLVVAQYIRNRRLDRCADDLRpaADDEKITSIAYKWGFSDSS 280

                          90
                  ....*....|....*....
gi 1149978421  88 SYSREFKKTFGVNPNNYRK 106
Cdd:PRK09685  281 HFSTAFKQRFGVSPGEYRR 299
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 6-107 1.03e-14

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 73.16  E-value: 1.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421   6 AIIVSVLEQIEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKlTSQSVTDIAFRMGFDS 85
Cdd:COG2169    84 DLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQ-TGLSVTDAAYAAGFGS 162

                          90       100
                  ....*....|....*....|..
gi 1149978421  86 VQSYSREFKKTFGVNPNNYRKA 107
Cdd:COG2169   163 LSRFYEAFKKLLGMTPSAYRRG 184
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
35-106 7.56e-11

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 61.46  E-value: 7.56e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1149978421  35 SRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRMGFDSVQSYSREFKKTFGVNPNNYRK 106
Cdd:PRK13501  205 VERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQ 276
AraC_E_bind smart00871
Bacterial transcription activator, effector binding domain; This domain is found in the ...
 128-284 1.28e-09

Bacterial transcription activator, effector binding domain; This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.


Pssm-ID: 214874 [Multi-domain]  Cd Length: 158  Bit Score: 55.95  E-value: 1.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421  128 QFEICQLTSKEIFGFQTSHQIATNDLPKKASPIKWKIIHETLRTWGEN--VYCLSSFKPDNTKDQviAVSSFFGMEHNS- 204
Cdd:smart00871   1 EVRIVELPAFKVAGLRHRGPNEDEKIPELWQRLIQWAKELGLLPVGNSgePYGVYYDDPDDTPDG--EFRYDAGVEVSDe 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421  205 VDGGKIPMSRVIKCGKYAKFHFVGH-KEQYQQFSNTIYMCILPKLNLIRREGEDIEYFHLASVQKQQNNESIVDlyYYIP 283
Cdd:smart00871  79 VEAPEGVETKTIPAGKYAVFTHKGGsYDEIQEAWEAIYGEWLPNSGYELRDAGPDFEVYLNDPPDTDPEELVTE--IYIP 156


                   .
gi 1149978421  284 V 284
Cdd:smart00871 157 V 157
ftrA PRK09393
transcriptional activator FtrA; Provisional
 11-106 1.36e-09

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 58.05  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421  11 VLEQIEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRMGFDSVQSYS 90
Cdd:PRK09393  223 LIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLR 302

                          90
                  ....*....|....*.
gi 1149978421  91 REFKKTFGVNPNNYRK 106
Cdd:PRK09393  303 HHFRRRAATSPAAYRK 318
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
8-106 1.44e-07

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 51.51  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421   8 IVSVLEQIEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRMGFDSVQ 87
Cdd:PRK10572  185 VREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQL 264

                          90
                  ....*....|....*....
gi 1149978421  88 SYSREFKKTFGVNPNNYRK 106
Cdd:PRK10572  265 YFSRVFKKCTGASPSEFRA 283
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
15-109 2.51e-07

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 50.83  E-value: 2.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421  15 IEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRMGFDSVQSYSREFK 94
Cdd:PRK13503  180 LEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFR 259

                          90
                  ....*....|....*
gi 1149978421  95 KTFGVNPNNYRKADF 109
Cdd:PRK13503  260 REFSWSPRDIRQGRD 274
PRK10371 PRK10371
transcriptional regulator MelR;
2-107 5.26e-06

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 47.12  E-value: 5.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421   2 MMKRAI--IVSVLEQIEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAF 79
Cdd:PRK10371  185 VSRHAQfyVSQMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIAL 264

                          90       100
                  ....*....|....*....|....*...
gi 1149978421  80 RMGFDSVQSYSREFKKTFGVNPNNYRKA 107
Cdd:PRK10371  265 TAGFRSSSRFYSTFGKYVGMSPQQYRKL 292
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
11-105 1.12e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 45.86  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421  11 VLEQIEKNLEERIDIEKLVVITGYSRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRMGFDSVQSYS 90
Cdd:PRK13500  211 LITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFS 290

                          90
                  ....*....|....*
gi 1149978421  91 REFKKTFGVNPNNYR 105
Cdd:PRK13500  291 VVFTRETGMTPSQWR 305
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
35-105 1.15e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 45.82  E-value: 1.15e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1149978421  35 SRRSLQDFFKEKCGVSIGKYIRQRKLSRSATLLKLTSQSVTDIAFRMGFDSVQSYSREFKKTFGVNPNNYR 105
Cdd:PRK13502  205 SERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWR 275
Cass2 pfam14526
Integron-associated effector binding protein; This family contains Cass2 from Vibrio cholerae, ...
 130-284 4.18e-05

Integron-associated effector binding protein; This family contains Cass2 from Vibrio cholerae, an integron-associated protein that has been shown to bind cationic drug compounds with submicromolar affinity. Cass2 has been proposed to be representative of a larger family of independent effector-binding proteins associated with lateral gene transfer within Vibrio and other closely-related species.


Pssm-ID: 434016 [Multi-domain]  Cd Length: 149  Bit Score: 42.73  E-value: 4.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421 130 EICQLTSKEIFGFQTSHQIATNDLPKKASP-----IKWKIIHET---LRTWGENVYCLSsfkPDNTKDQVIAVSSffgme 201
Cdd:pfam14526   1 EIVELPSFTVAGIRYEGPNEYEDHNKEIGKfweefNEDGRLPNIkkdDKSYGIYVDYED---EENEFDYYAGVEV----- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149978421 202 hNSVDGGKIPM-SRVIKCGKYAKFHFVGHKEQ-YQQFSNTIYMCILPKLNLIRREGEDIEYFHlasvqKQQNNESIVDLy 279
Cdd:pfam14526  73 -PSFSELPEGLvVIEIPGGKYAVFTIEGDFPDaIAEAWTRIYGWLLPNSGYERAGGPDFEVYK-----ENGDENMKIEL- 145


                  ....*
gi 1149978421 280 yYIPV 284
Cdd:pfam14526 146 -YIPV 149
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 65-106 5.58e-05

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 43.59  E-value: 5.58e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1149978421  65 TLLKLTSQSVTDIAFRMGFDSVQSYSREFKKTFGVNPNNYRK 106
Cdd:PRK10296  231 KQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYRK 272
YdeE COG3708
Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription] ...
 219-284 9.13e-05

Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription];


Pssm-ID: 442922  Cd Length: 157  Bit Score: 41.93  E-value: 9.13e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1149978421 219 GKYAKFHFVGH-KEQYQQFSNTIYMCILPKLNLIRREGEDIEYFHLASvqkQQNNESIVDlyYYIPV 284
Cdd:COG3708    95 GTYAVFTHKGPmPEALQETWQYIYSEWLPSSGYERADGPDFEVYDERD---DPSPDSEVE--IWIPI 156
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 70-106 2.63e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 34.82  E-value: 2.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1149978421  70 TSQSVTDIAFRMGFdSVQSYSREFKKTFGVNPNNYRK 106
Cdd:pfam00165   7 TNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 54-106 6.53e-03

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 37.67  E-value: 6.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1149978421  54 YIRQRkLSRSATLLKLTSQSVTDIAFRMGFDSVQSYSREFKKTFGVNPNNYRK 106
Cdd:PRK15185  254 YLSAR-MNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTFIK 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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