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Conserved domains on  [gi|1130903226|ref|WP_075673044|]
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MULTISPECIES: methyl-accepting chemotaxis protein [Proteus]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 1003728)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MCP_signal super family cl46910
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 1-568 0e+00

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


The actual alignment was detected with superfamily member PRK15041:

Pssm-ID: 481250 [Multi-domain]  Cd Length: 554  Bit Score: 588.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226   1 MFSRMKIVTGLLSILLLFGVLQFVSGGVFYSNIVETRNDLNKTLTIQDQRERLDESWANLLQARNNINRAAISFLLqDKN 80
Cdd:PRK15041    1 MLKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMM-DQN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  81 lNVDDSLSVDYLtglarknMSRADEKFKEFEKNITAYQV------HSEDDVRSLKGRFIEYYSALNQLEILLQDKNLKDF 154
Cdd:PRK15041   80 -NIGSGSTVAEL-------MQSASISLKQAEKNWADYEAlprdprQSTAAAAEIKRNYDIYHNALAELIQLLGAGKINEF 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 155 FEQPTTGYQDAFYKEYLAYVMRNEKFNEELNVALEASHQRTVITMVVLAIIVISALILCWFALRNALIRPLNSLLVSIKT 234
Cdd:PRK15041  152 FDQPTQGYQDGFEKQYVAYMEQNDRLYDIAVSDNNASYSQAMWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRH 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 235 FSEGDLRPNIEVNGRNEMSLLANGLKHMQQELIQTVRGVYQSTENIYNSTSEIAAGNNDLSARTEEQVASLEETAASMEQ 314
Cdd:PRK15041  232 IAGGDLVKPIEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQ 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 315 LTATVKQNADNARQASNLANDASDIARQGGKVVANVVQTMHDIAGSSQKITDITAVIDGIAFQTNILALNAAVEAARAGE 394
Cdd:PRK15041  312 LTATVKQNAENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGE 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 395 HGRGFAVVAGEVRNLAQRSAEAAKEIKTLIEDSVSRTETGSVLVESAGETMTRIVDSVTRVTDIMGEIASASDEQSRGIS 474
Cdd:PRK15041  392 QGRGFAVVAGEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGID 471

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 475 QVGLAVSEMDRVTQQNASLVEQSAAAAAGLEDQAVALTRLVSIFKLPGQEEKTLErkesdATPVVKAAAPLIKPgtsekk 554
Cdd:PRK15041  472 QVGLAVAEMDRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQQQQQQQRE-----TSAVVKTVTPATPR------ 540

                         570
                  ....*....|....
gi 1130903226 555 KSSSVEDPANWETF 568
Cdd:PRK15041  541 KMAVADSGENWETF 554
 
Name Accession Description Interval E-value
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
1-568 0e+00

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 588.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226   1 MFSRMKIVTGLLSILLLFGVLQFVSGGVFYSNIVETRNDLNKTLTIQDQRERLDESWANLLQARNNINRAAISFLLqDKN 80
Cdd:PRK15041    1 MLKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMM-DQN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  81 lNVDDSLSVDYLtglarknMSRADEKFKEFEKNITAYQV------HSEDDVRSLKGRFIEYYSALNQLEILLQDKNLKDF 154
Cdd:PRK15041   80 -NIGSGSTVAEL-------MQSASISLKQAEKNWADYEAlprdprQSTAAAAEIKRNYDIYHNALAELIQLLGAGKINEF 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 155 FEQPTTGYQDAFYKEYLAYVMRNEKFNEELNVALEASHQRTVITMVVLAIIVISALILCWFALRNALIRPLNSLLVSIKT 234
Cdd:PRK15041  152 FDQPTQGYQDGFEKQYVAYMEQNDRLYDIAVSDNNASYSQAMWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRH 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 235 FSEGDLRPNIEVNGRNEMSLLANGLKHMQQELIQTVRGVYQSTENIYNSTSEIAAGNNDLSARTEEQVASLEETAASMEQ 314
Cdd:PRK15041  232 IAGGDLVKPIEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQ 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 315 LTATVKQNADNARQASNLANDASDIARQGGKVVANVVQTMHDIAGSSQKITDITAVIDGIAFQTNILALNAAVEAARAGE 394
Cdd:PRK15041  312 LTATVKQNAENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGE 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 395 HGRGFAVVAGEVRNLAQRSAEAAKEIKTLIEDSVSRTETGSVLVESAGETMTRIVDSVTRVTDIMGEIASASDEQSRGIS 474
Cdd:PRK15041  392 QGRGFAVVAGEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGID 471

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 475 QVGLAVSEMDRVTQQNASLVEQSAAAAAGLEDQAVALTRLVSIFKLPGQEEKTLErkesdATPVVKAAAPLIKPgtsekk 554
Cdd:PRK15041  472 QVGLAVAEMDRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQQQQQQQRE-----TSAVVKTVTPATPR------ 540

                         570
                  ....*....|....
gi 1130903226 555 KSSSVEDPANWETF 568
Cdd:PRK15041  541 KMAVADSGENWETF 554
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
30-520 1.90e-103

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 321.97  E-value: 1.90e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  30 YSNIVETRNDLNKTLTIQDQRERLDESWANLLQARNNINRAAISFLLQDKNLNVDDSLSVDYLTGLARKNMSRADEKFKE 109
Cdd:COG0840    14 LLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 110 FEKNITAYQVHSEDDVRSLKGRFIEYYSALNQLEILLQDKNLKDFFEQPTTGYQDAFYKEYLAYVMRNEKFNEELNVALE 189
Cdd:COG0840    94 ALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 190 ASHQRTVITMVVLAIIVISAL-ILCWFALRNALIRPLNSLLVSIKTFSEGDLRPNIEVNGRNEMSLLANGLKHMQQELIQ 268
Cdd:COG0840   174 LAAAALALALLAAALLALVALaIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRE 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 269 TVRGVYQSTENIYNSTSEIAAGNNDLSARTEEQVASLEETAASMEQLTATVKQNADNARQASNLANDASDIARQGGKVVA 348
Cdd:COG0840   254 LVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEEGGEVVE 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 349 NVV--------------QTMHDIAGSSQKITDITAVIDGIAFQTNILALNAAVEAARAGEHGRGFAVVAGEVRNLAQRSA 414
Cdd:COG0840   334 EAVegieeiresveetaETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSA 413

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 415 EAAKEIKTLIEDSVSRTETGSVLVES--------------AGETMTRIVDSVTRVTDIMGEIASASDEQSRGISQVGLAV 480
Cdd:COG0840   414 EATKEIEELIEEIQSETEEAVEAMEEgseeveegvelveeAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTEEVNQAI 493

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1130903226 481 SEMDRVTQQNASLVEQSAAAAAGLEDQAVALTRLVSIFKL 520
Cdd:COG0840   494 EQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 275-519 3.69e-79

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 249.90  E-value: 3.69e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  275 QSTENIYNSTSEIAAGNNDLSARTEEQVASLEETAASMEQLTATVKQNADNARQASNLANDASDIARQGGKVVANVVQTM 354
Cdd:smart00283   4 EAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVSAV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  355 HDIAGSSQKITDITAVIDGIAFQTNILALNAAVEAARAGEHGRGFAVVAGEVRNLAQRSAEAAKEIKTLI---------- 424
Cdd:smart00283  84 EELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIkeiqeetnea 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  425 ----EDSVSRTETGSVLVESAGETMTRIVDSVTRVTDIMGEIASASDEQSRGISQVGLAVSEMDRVTQQNASLVEQSAAA 500
Cdd:smart00283 164 vaamEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEISAA 243

                          250
                   ....*....|....*....
gi 1130903226  501 AAGLEDQAVALTRLVSIFK 519
Cdd:smart00283 244 AEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 299-498 5.32e-65

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 210.56  E-value: 5.32e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 299 EEQVASLEETAASMEQLTATVKQNADNARQASNLANDASDIARQGGKVVANVVQTMHDIAGSSQKITDITAVIDGIAFQT 378
Cdd:cd11386     1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 379 NILALNAAVEAARAGEHGRGFAVVAGEVRNLAQRSAEAAKEIKTLIEDSVSRTETGSVLVESAGETMTRIVDSVTRVTDI 458
Cdd:cd11386    81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1130903226 459 MGEIASASDEQSRGISQVGLAVSEMDRVTQQNASLVEQSA 498
Cdd:cd11386   161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 330-487 1.04e-64

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 208.83  E-value: 1.04e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 330 SNLANDASDIARQGGKVVANVVQTMHDIAGSSQKITDITAVIDGIAFQTNILALNAAVEAARAGEHGRGFAVVAGEVRNL 409
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 410 AQRSAEAAKEIKTLI--------------EDSVSRTETGSVLVESAGETMTRIVDSVTRVTDIMGEIASASDEQSRGISQ 475
Cdd:pfam00015  81 AERSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQ 160

                         170
                  ....*....|..
gi 1130903226 476 VGLAVSEMDRVT 487
Cdd:pfam00015 161 VNQAVARMDQVT 172
 
Name Accession Description Interval E-value
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
1-568 0e+00

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 588.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226   1 MFSRMKIVTGLLSILLLFGVLQFVSGGVFYSNIVETRNDLNKTLTIQDQRERLDESWANLLQARNNINRAAISFLLqDKN 80
Cdd:PRK15041    1 MLKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMM-DQN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  81 lNVDDSLSVDYLtglarknMSRADEKFKEFEKNITAYQV------HSEDDVRSLKGRFIEYYSALNQLEILLQDKNLKDF 154
Cdd:PRK15041   80 -NIGSGSTVAEL-------MQSASISLKQAEKNWADYEAlprdprQSTAAAAEIKRNYDIYHNALAELIQLLGAGKINEF 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 155 FEQPTTGYQDAFYKEYLAYVMRNEKFNEELNVALEASHQRTVITMVVLAIIVISALILCWFALRNALIRPLNSLLVSIKT 234
Cdd:PRK15041  152 FDQPTQGYQDGFEKQYVAYMEQNDRLYDIAVSDNNASYSQAMWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRH 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 235 FSEGDLRPNIEVNGRNEMSLLANGLKHMQQELIQTVRGVYQSTENIYNSTSEIAAGNNDLSARTEEQVASLEETAASMEQ 314
Cdd:PRK15041  232 IAGGDLVKPIEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQ 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 315 LTATVKQNADNARQASNLANDASDIARQGGKVVANVVQTMHDIAGSSQKITDITAVIDGIAFQTNILALNAAVEAARAGE 394
Cdd:PRK15041  312 LTATVKQNAENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGE 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 395 HGRGFAVVAGEVRNLAQRSAEAAKEIKTLIEDSVSRTETGSVLVESAGETMTRIVDSVTRVTDIMGEIASASDEQSRGIS 474
Cdd:PRK15041  392 QGRGFAVVAGEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGID 471

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 475 QVGLAVSEMDRVTQQNASLVEQSAAAAAGLEDQAVALTRLVSIFKLPGQEEKTLErkesdATPVVKAAAPLIKPgtsekk 554
Cdd:PRK15041  472 QVGLAVAEMDRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQQQQQQQRE-----TSAVVKTVTPATPR------ 540

                         570
                  ....*....|....
gi 1130903226 555 KSSSVEDPANWETF 568
Cdd:PRK15041  541 KMAVADSGENWETF 554
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 1-568 0e+00

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 551.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226   1 MFSRMKIVTGLLSILLLFGVLQFVSGGVFYSNIVETRNDLNKTLTIQDQRERLDESWANLLQARNNINRAAISFLLqDKN 80
Cdd:PRK15048    1 MINRIRVVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMM-DSS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  81 lNVDDSLSVDYLTGlARKNMSRADEKFKEFeKNITAyQVHSEDDVRSLKGRFIEYYSALNQLEILLQDKNLKDFFEQPTT 160
Cdd:PRK15048   80 -NQQSNAKVELLDS-ARKTLAQAATHYKKF-KSMAP-LPEMVATSRNIDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 161 GYQDAFYKEYLAYVMRNEKFNEELNVALEASHQRTVITMVVLAIIVISALILCWFALRNALIRPLNSLLVSIKTFSEGDL 240
Cdd:PRK15048  156 GMQNAMGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 241 RPNIEVNGRNEMSLLANGLKHMQQELIQTVRGVYQSTENIYNSTSEIAAGNNDLSARTEEQVASLEETAASMEQLTATVK 320
Cdd:PRK15048  236 ANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVK 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 321 QNADNARQASNLANDASDIARQGGKVVANVVQTMHDIAGSSQKITDITAVIDGIAFQTNILALNAAVEAARAGEHGRGFA 400
Cdd:PRK15048  316 QNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFA 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 401 VVAGEVRNLAQRSAEAAKEIKTLIEDSVSRTETGSVLVESAGETMTRIVDSVTRVTDIMGEIASASDEQSRGISQVGLAV 480
Cdd:PRK15048  396 VVAGEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAV 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 481 SEMDRVTQQNASLVEQSAAAAAGLEDQAVALTRLVSIFKL---PGQEEKTLERKESDATPVvkaaaplikpgtsEKKKSS 557
Cdd:PRK15048  476 SEMDRVTQQNASLVQESAAAAAALEEQASRLTQAVSAFRLaasPLTNKPQTPSRPASEQPP-------------AQPRLR 542

                         570
                  ....*....|.
gi 1130903226 558 SVEDPANWETF 568
Cdd:PRK15048  543 IAEQDPNWETF 553
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
1-539 5.32e-155

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 454.53  E-value: 5.32e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226   1 MFSRMKIVTGLLSILLLFGVLQFVSGGVFYSNIVETRNDLNKTLTIQDQRERLDESWANLLQARNNINRA----AISFLL 76
Cdd:PRK09793    1 MFNRIRISTTLFLILILCGILQIGSNGMSFWAFRDDLQRLNQVEQSNQQRAALAQTRAVMLQASTALNKAgtltALSYPA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  77 QDknlnvddslsVDYLTGLARKNMSRADEKFKEFEKNiTAYQVHSEDDVRSLKGRFIEYYSALNQLEILLQDKNLKDFFE 156
Cdd:PRK09793   81 DD----------IKTLMTTARASLTQSTTLFKSFMAM-TAGNEHVRALQKETEKSFARWHNDLEHQATWLESNQLSDFLT 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 157 QPTTGYQDAFYKEYLAYVMRNEKFNEELNVALEASHQRT---VITMVVLAIIVISALILcWfaLRNALIRPLNSLLVSIK 233
Cdd:PRK09793  150 APVQGSQNAFDVNFEAWQLEINHVLEAASAQSQRNYQISalvFISMIIVAAIYISSALW-W--TRKMIVQPLAIIGSHFD 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 234 TFSEGDLRPNIEVNGRNEMSLLANGLKHMQQELIQTVRGVYQSTENIYNSTSEIAAGNNDLSARTEEQVASLEETAASME 313
Cdd:PRK09793  227 SIAAGNLARPIAVYGRNEITAIFASLKTMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASME 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 314 QLTATVKQNADNARQASNLANDASDIARQGGKVVANVVQTMHDIAGSSQKITDITAVIDGIAFQTNILALNAAVEAARAG 393
Cdd:PRK09793  307 QLTATVGQNADNARQASELAKNAATTAQAGGVQVSTMTHTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAG 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 394 EHGRGFAVVAGEVRNLAQRSAEAAKEIKTLIEDSVSRTETGSVLVESAGETMTRIVDSVTRVTDIMGEIASASDEQSRGI 473
Cdd:PRK09793  387 EQGRGFAVVAGEVRNLASRSAQAAKEIKGLIEESVNRVQQGSKLVNNAAATMTDIVSSVTRVNDIMGEIASASEEQRRGI 466

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1130903226 474 SQVGLAVSEMDRVTQQNASLVEQSAAAAAGLEDQAVALTRLVSIFKLPGQEEKTLERKESDATPVV 539
Cdd:PRK09793  467 EQVAQAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAVFTLEEHEVARHESAQLQIAPVV 532
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
30-520 1.90e-103

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 321.97  E-value: 1.90e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  30 YSNIVETRNDLNKTLTIQDQRERLDESWANLLQARNNINRAAISFLLQDKNLNVDDSLSVDYLTGLARKNMSRADEKFKE 109
Cdd:COG0840    14 LLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 110 FEKNITAYQVHSEDDVRSLKGRFIEYYSALNQLEILLQDKNLKDFFEQPTTGYQDAFYKEYLAYVMRNEKFNEELNVALE 189
Cdd:COG0840    94 ALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 190 ASHQRTVITMVVLAIIVISAL-ILCWFALRNALIRPLNSLLVSIKTFSEGDLRPNIEVNGRNEMSLLANGLKHMQQELIQ 268
Cdd:COG0840   174 LAAAALALALLAAALLALVALaIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRE 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 269 TVRGVYQSTENIYNSTSEIAAGNNDLSARTEEQVASLEETAASMEQLTATVKQNADNARQASNLANDASDIARQGGKVVA 348
Cdd:COG0840   254 LVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEEGGEVVE 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 349 NVV--------------QTMHDIAGSSQKITDITAVIDGIAFQTNILALNAAVEAARAGEHGRGFAVVAGEVRNLAQRSA 414
Cdd:COG0840   334 EAVegieeiresveetaETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSA 413

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 415 EAAKEIKTLIEDSVSRTETGSVLVES--------------AGETMTRIVDSVTRVTDIMGEIASASDEQSRGISQVGLAV 480
Cdd:COG0840   414 EATKEIEELIEEIQSETEEAVEAMEEgseeveegvelveeAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTEEVNQAI 493

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1130903226 481 SEMDRVTQQNASLVEQSAAAAAGLEDQAVALTRLVSIFKL 520
Cdd:COG0840   494 EQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 275-519 3.69e-79

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 249.90  E-value: 3.69e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  275 QSTENIYNSTSEIAAGNNDLSARTEEQVASLEETAASMEQLTATVKQNADNARQASNLANDASDIARQGGKVVANVVQTM 354
Cdd:smart00283   4 EAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVSAV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  355 HDIAGSSQKITDITAVIDGIAFQTNILALNAAVEAARAGEHGRGFAVVAGEVRNLAQRSAEAAKEIKTLI---------- 424
Cdd:smart00283  84 EELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIkeiqeetnea 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  425 ----EDSVSRTETGSVLVESAGETMTRIVDSVTRVTDIMGEIASASDEQSRGISQVGLAVSEMDRVTQQNASLVEQSAAA 500
Cdd:smart00283 164 vaamEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEISAA 243

                          250
                   ....*....|....*....
gi 1130903226  501 AAGLEDQAVALTRLVSIFK 519
Cdd:smart00283 244 AEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 299-498 5.32e-65

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 210.56  E-value: 5.32e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 299 EEQVASLEETAASMEQLTATVKQNADNARQASNLANDASDIARQGGKVVANVVQTMHDIAGSSQKITDITAVIDGIAFQT 378
Cdd:cd11386     1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 379 NILALNAAVEAARAGEHGRGFAVVAGEVRNLAQRSAEAAKEIKTLIEDSVSRTETGSVLVESAGETMTRIVDSVTRVTDI 458
Cdd:cd11386    81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1130903226 459 MGEIASASDEQSRGISQVGLAVSEMDRVTQQNASLVEQSA 498
Cdd:cd11386   161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 330-487 1.04e-64

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 208.83  E-value: 1.04e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 330 SNLANDASDIARQGGKVVANVVQTMHDIAGSSQKITDITAVIDGIAFQTNILALNAAVEAARAGEHGRGFAVVAGEVRNL 409
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 410 AQRSAEAAKEIKTLI--------------EDSVSRTETGSVLVESAGETMTRIVDSVTRVTDIMGEIASASDEQSRGISQ 475
Cdd:pfam00015  81 AERSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQ 160

                         170
                  ....*....|..
gi 1130903226 476 VGLAVSEMDRVT 487
Cdd:pfam00015 161 VNQAVARMDQVT 172
Tar_Tsr_sensor cd19407
ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar ...
 45-178 1.90e-30

ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar (taxis to aspartate and repellents) and Tsr (taxis to serine and repellents) are homologous transmembrane chemoreceptors that have a high specificity for aspartate and serine, respectively. Both are homodimeric receptors and contain an N-terminal periplasmic ligand binding domain, a transmembrane region, a HAMP domain and a C-terminal cytosolic signaling domain. E. coli Tar mediates bacterial chemotaxis toward attractants, including aspartate (Asp) and maltose, and away from repellents such as nickel and cobalt ions. Tsr has many roles, including sensing of external (serine, leucine) and internal (pH) environments. In Salmonella enterica serovar Typhimurium, Tsr, also called methyl-accepting chemotaxis protein (MCP), is involved in sensing host-derived nitrate in murine intestinal epithelium, thus contributing to invasion of Peyer's patches. This model represents the ligand binding domain of Tar and Tsr.


Pssm-ID: 438625 [Multi-domain]  Cd Length: 131  Bit Score: 115.50  E-value: 1.90e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  45 TIQDQRERLDESWANLLQARNNINRAAISFLLQDKNLNVDDslsVDYLTGLARKNMSRADEKFKEFeKNITAYQVHSEDD 124
Cdd:cd19407     2 QLRQQQSALNDSWVALLQARNTLNRAAIRYLLDANNGGGAA---VAELLDQAKKSLAQAEKHFAQF-KALPKLPGQDEAL 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1130903226 125 VRSLKGRFIEYYSALNQLEILLQDKNLKDFFEQPTTGYQDAFYKEYLAYVMRNE 178
Cdd:cd19407    78 AAELEQSYQAYHDALAELIQFLEAGNIDAFLDQPTQGYQDAFEKAYNAYLAQNN 131
TarH pfam02203
Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a ...
 26-173 2.33e-12

Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a number of methyl-accepting chemotaxis receptors, such as E.coli Tar (taxis to aspartate and repellents), which is a receptor for the attractant L-aspartate and also recognizes proteogenic amino acids, phthalic acid, Malic acid, 3,4-dihydroxymandelic acid, citrate, benzoate and derivatives, protocatechuate, vanillate, quinate, shikimate and dehydroshikimate (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426656 [Multi-domain]  Cd Length: 152  Bit Score: 65.02  E-value: 2.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  26 GGVFYSNIVETRNDLNKTLTIQ-DQRERLDESWANLLQARNNINRAAISFLLqdknlnvDDSLSVDYLTGLARKNMSRAD 104
Cdd:pfam02203   1 GGLGLSGLSRSNDALREVYTNRlQQQAALADAWLLLLQARLTLNRAGIAALL-------PDAPDAAELLARARESLAQSD 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1130903226 105 EKFKEFEknitAYQVHSEDDVR---SLKGRFIEYYSALNQLEILLQDKNLKDFFEQPTTGYQDAFYKEYLAY 173
Cdd:pfam02203  74 AAWKAYL----ALPRTPDEEEAlaaELKAKYDALQDGLAPLIAALRAGDLDAFFDQPTQKIQPLFEALYNAY 141
TarH smart00319
Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the ...
 45-179 3.07e-12

Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the wild-type bacterial aspartate receptor, Tar.


Pssm-ID: 128614 [Multi-domain]  Cd Length: 135  Bit Score: 64.02  E-value: 3.07e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226   45 TIQDQRERLDESWANLLQARNNINRAAIsfLLQDKNLNVDDSLSVDYltglARKNMSRADEKFKEFEkNITAYQVHSEDD 124
Cdd:smart00319   2 TSSYQQAALSLSRVLLLQARNNLNRAGI--RMMQNNIGSKAKKLMTA----ASESLKQAEKNYKSYE-NMTALPRADRAL 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1130903226  125 VRSLKGRFIEYYSALNQLEILLQDKNLKDFFEQPTTGYQDAFYKEYLAYVMRNEK 179
Cdd:smart00319  75 DAELKEKFQQYITALQELIQILGNGNLGAFFDQPTQGMQDGFDPAYRDWLQQAVA 129
HAMP pfam00672
HAMP domain;
217-268 5.88e-07

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 46.46  E-value: 5.88e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1130903226 217 LRNALIRPLNSLLVSIKTFSEGDLRPNIEVNGRNEMSLLANGLKHMQQELIQ 268
Cdd:pfam00672   2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
197-307 1.12e-05

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 48.13  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 197 ITMV--VLAIIVISALILCWFALRNALIRPLNSLLVSIKTFSEGDLRPNIEVNGRNEMSLLANGLKHMQQELiqtvrgvy 274
Cdd:PRK10600  123 VVLVhrVFAVFMALLLVFTIIWLRRRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAEL-------- 194

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1130903226 275 qsteniynstseiAAGNNDLSARTEEQVASLEE 307
Cdd:PRK10600  195 -------------AESYAVLEQRVQEKTAGLEQ 214
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
221-271 1.64e-05

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 42.24  E-value: 1.64e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1130903226  221 LIRPLNSLLVSIKTFSEGDLRPNIEVNGRNEMSLLANGLKHMQQELIQTVR 271
Cdd:smart00304   3 LLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
1-535 2.64e-05

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 47.03  E-value: 2.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226   1 MFSRMKIVTGLLSILLLFGVLQFVSGGVFYSNIVETRNDLNKTLTIQDQRERLDESWANLLQARNNINRAAISFLLQDKN 80
Cdd:COG2770    16 LLLLLLAGALLVLALISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  81 LNVDDSLSVDYLTGLARKNMSRADEKFKEFEKNITAYQVHSEDDVRSLKGRFIEYYSALNQLEILLQDKNLKDFFEQPTT 160
Cdd:COG2770    96 LLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLL 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 161 GYQDAFYKEYLAYVMRNEKFNEELNVALEASHQRTVITMVVLAIIVISALILCWFALRNALIRPLNSLLVSIKTFSEGDL 240
Cdd:COG2770   176 LADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDL 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 241 RPNIEVNGRNEMSLLANGLKHMQQELIQTVRGVYQSTENIYNSTSEIAAgnNDLSARTEEQVASLEETAASMEQLTATVK 320
Cdd:COG2770   256 DVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLE--ALLELLLALLLLLLALLLLAAAALLLELL 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 321 QNADNARQASNLANDASDIARQGGKVVANVVQTMHDIAGSSQKITDITAVIDGIAFQTNILALNAAVEAARAGEHGRGFA 400
Cdd:COG2770   334 LLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELV 413

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 401 VVAGEVRNLAQRSAEAAKEIKTLIEDSVSRTETGSVLVESAGETMTRIVDSVTRVTDIMGEIASASDEQSRGISQVGLAV 480
Cdd:COG2770   414 LALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLE 493

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1130903226 481 SEMDRVTQQNASLVEQSAAAAAGLEDQAVALTRLVSIFKLPGQEEKTLERKESDA 535
Cdd:COG2770   494 EEEEAGAAAEELAEELLLLEGLLLLLLLEAEALEVAEELLELEEAALLLAAAAEL 548
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 222-266 4.01e-05

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 40.89  E-value: 4.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1130903226 222 IRPLNSLLVSIKTFSEGDLRPNIEVNGRNEMSLLANGLKHMQQEL 266
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 194-266 5.85e-05

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 45.72  E-value: 5.85e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1130903226 194 RTVITMVVLAIIVISALILCWFALR--NALIRPLNSLLVSIKTFSEGDLRPNIEVNGRNEMSLLANGLKHMQQEL 266
Cdd:COG5000     4 QILFLLLLLLIALLLLLLALWLALLlaRRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQL 78
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 268-342 3.97e-04

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 42.27  E-value: 3.97e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1130903226  268 QTVRGVYQSTENIYNSTSEIAAGNNDLSARTEEQVASLEETAASMEQLTATVKQNADNARQASNLANDASDIARQ 342
Cdd:smart00283 179 ELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEISAAAEELSGLAEE 253
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 89-536 5.07e-04

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 42.95  E-value: 5.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226  89 VDYLTGLARKNMSRADEKFKEFEKNITAYQVHSEDDVRSLKGRFIEYYSALNQLEILLQDKNLKDFFEQPTTGYQDAFYK 168
Cdd:COG3850    11 LLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 169 EYLAYVMRNEKFNEELNVALEASHQRTVITMVVLAIIVISALILCWFaLRNALIRPLNSLLVSIKTFSEGDLRPNIEVNG 248
Cdd:COG3850    91 SLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYL-LRRRIVRPLRRLTQAAERIARGDFDARVPVSG 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 249 RNEMSLLANGLKHMQQELIQTVRGVyqsteniynSTSEIAAGNNDLSARTEEQVASLEETAASMEQLTATVKQNADNARQ 328
Cdd:COG3850   170 RDELGTLARAFNRMADELQELYAEL---------EEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 329 ASNLANDASDIARQGGKVVANVVQTMHDIAGSSQKITDITAVIDGIAFQTNILALNAAVEAARAGEHGRGFAVVAGEVRN 408
Cdd:COG3850   241 LLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 409 LAQRSAEAAKEIKTLIEDSVSRTETGSVLVESAGETMTRIVDSVTRVTDIMGEIASASDEQSRGISQVGLAVSEMDRVTQ 488
Cdd:COG3850   321 QAIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQG 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1130903226 489 QNASLVEQSAAAAAGLEDQAVALTRLVSIFKLPGQEEKTLERKESDAT 536
Cdd:COG3850   401 AGLVDVEGGVAGEGGLVVLIVSIIAGGEAIARGEALAARGLAAAAALA 448
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
188-275 6.88e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 42.31  E-value: 6.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 188 LEASHQRTVITMVVLAIIVISALILCWFALRNALIRPLNSLLVSIKTFSEGDLRPnIEVNGRNEMSLLANGLKHMQQELI 267
Cdd:COG2972   148 LFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR-LEVSGNDEIGILARSFNEMVERIK 226


                  ....*...
gi 1130903226 268 QTVRGVYQ 275
Cdd:COG2972   227 ELIEEVYE 234
Rgp1 pfam08737
Rgp1; Rgp1 forms heterodimer with Ric1 (pfam07064) which associates with Golgi membranes and ...
 276-388 3.18e-03

Rgp1; Rgp1 forms heterodimer with Ric1 (pfam07064) which associates with Golgi membranes and functions as a guanyl-nucleotide exchange factor.


Pssm-ID: 430181  Cd Length: 414  Bit Score: 39.95  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130903226 276 STENIYNSTSEIAAGNNDLSARTEEQVASLEETAASMEQLTATVKQNADNARQASNLANDAS--DIARQGgKVVANVVqt 353
Cdd:pfam08737 234 ENENNSKDIDELLSPQLEVQFGEEEDSEENESRRSSSVEKPSSVKEAIDLLILRSQLQNLQKsyEIARNG-KRIAVLT-- 310

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1130903226 354 mhdIAGSSQKITD-ITAVIDGIAFQTNILALNAAVE 388
Cdd:pfam08737 311 ---LSKPAYRLGEtIDLVIDFSDARIPCYAVTATLE 343
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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