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Conserved domains on  [gi|1126537105|ref|WP_075174667|]
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MarR family winged helix-turn-helix transcriptional regulator [Acinetobacter indicus]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-136 2.80e-19

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 78.09  E-value: 2.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126537105   2 PSSPLKFRTALLRCARLFSDEVNTLLLPHQLNYSLWQVLYVIHLKQQCTQVDIAAYLKVSKPSITKRIRVLLDLGLIHQL 81
Cdd:COG1846     6 DPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVERE 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1126537105  82 ES-SDKRQKCLTFSSHGQELFQHCSSQIDQFEQQLLQSFAVTDIAHTREILNQLSE 136
Cdd:COG1846    86 PDpEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-136 2.80e-19

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 78.09  E-value: 2.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126537105   2 PSSPLKFRTALLRCARLFSDEVNTLLLPHQLNYSLWQVLYVIHLKQQCTQVDIAAYLKVSKPSITKRIRVLLDLGLIHQL 81
Cdd:COG1846     6 DPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVERE 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1126537105  82 ES-SDKRQKCLTFSSHGQELFQHCSSQIDQFEQQLLQSFAVTDIAHTREILNQLSE 136
Cdd:COG1846    86 PDpEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
27-119 2.92e-14

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 64.15  E-value: 2.92e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126537105   27 LLPHQLNYSLWQVLYVIHLKQQCTQVDIAAYLKVSKPSITKRIRVLLDLGLIHQLES-SDKRQKCLTFSSHGQELFQHCS 105
Cdd:smart00347   3 LKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSpEDRRSVLVSLTEEGRELIEQLL 82

                           90
                   ....*....|....
gi 1126537105  106 SQIDQFEQQLLQSF 119
Cdd:smart00347  83 EARSETLAELLAGL 96
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 30-88 9.93e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 46.04  E-value: 9.93e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126537105  30 HQLNYSLWQVLYVIHLKQQCTQVDIAAYLKVSKPSITKRIRVLLDLGLIHQLESS-DKRQ 88
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPaDRRA 60
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 45-78 4.24e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.20  E-value: 4.24e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1126537105  45 LKQQCTQVDIAAYLKVSKPSITKRIRVLLDLGLI 78
Cdd:cd00090    17 LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLV 50
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-136 2.80e-19

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 78.09  E-value: 2.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126537105   2 PSSPLKFRTALLRCARLFSDEVNTLLLPHQLNYSLWQVLYVIHLKQQCTQVDIAAYLKVSKPSITKRIRVLLDLGLIHQL 81
Cdd:COG1846     6 DPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVERE 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1126537105  82 ES-SDKRQKCLTFSSHGQELFQHCSSQIDQFEQQLLQSFAVTDIAHTREILNQLSE 136
Cdd:COG1846    86 PDpEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
27-119 2.92e-14

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 64.15  E-value: 2.92e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126537105   27 LLPHQLNYSLWQVLYVIHLKQQCTQVDIAAYLKVSKPSITKRIRVLLDLGLIHQLES-SDKRQKCLTFSSHGQELFQHCS 105
Cdd:smart00347   3 LKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSpEDRRSVLVSLTEEGRELIEQLL 82

                           90
                   ....*....|....
gi 1126537105  106 SQIDQFEQQLLQSF 119
Cdd:smart00347  83 EARSETLAELLAGL 96
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 30-88 9.93e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 46.04  E-value: 9.93e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126537105  30 HQLNYSLWQVLYVIHLKQQCTQVDIAAYLKVSKPSITKRIRVLLDLGLIHQLESS-DKRQ 88
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPaDRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 32-89 3.71e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 41.76  E-value: 3.71e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1126537105  32 LNYSLWQVLYVIHLKQQCTQVDIAAYLKVSKPSITKRIRVLLDLGLIHQLES-SDKRQK 89
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSpEDRREV 59
HTH_27 pfam13463
Winged helix DNA-binding domain;
32-97 5.37e-04

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 36.50  E-value: 5.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1126537105  32 LNYSLWQVLYVI-HLKQQCTQVDIAAYLKVSKPSITKRIRVLLDLGLIHQLES-SDKRQKCLTFSSHG 97
Cdd:pfam13463   1 LTRLEALILHNIgHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSeEDGRETRVRLTAKG 68
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
46-80 5.53e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 37.49  E-value: 5.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1126537105  46 KQQCTQVDIAAYLKVSKPSITKRIRVLLDLGLIHQ 80
Cdd:COG1321    22 GGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEY 56
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 45-78 4.24e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.20  E-value: 4.24e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1126537105  45 LKQQCTQVDIAAYLKVSKPSITKRIRVLLDLGLI 78
Cdd:cd00090    17 LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLV 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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