|
Name |
Accession |
Description |
Interval |
E-value |
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
22-501 |
2.11e-115 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 349.37 E-value: 2.11e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 22 ILAAILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVL 101
Cdd:TIGR00711 1 LLLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 102 SLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFF 181
Cdd:TIGR00711 81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 182 INVPIAAAGGLGLLYLMRGQQETVTRsPIDVVGLGLLIVWVGALQIMLDEGRNHDWFAATEIRVLAVIAVIGFVAFLMWE 261
Cdd:TIGR00711 161 INVPIGIIVVVVAFFILPRDKPAASE-NFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 262 LTEKNPIVNLHVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLD 341
Cdd:TIGR00711 240 LTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKID 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 342 PRLIVSVGLLGLGGISAWR-VGFTPDITFIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAF 420
Cdd:TIGR00711 320 PRKLVTIGLILYAVGFYWRaFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSI 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 421 ATSIVQTGWANATRENQTELAS----AMTQGQTTLDSMMASGMSREVATSTLSSIVEGQSVMLATLNMFAAIAFCFAFAA 496
Cdd:TIGR00711 400 GTALITTILTNRTQFHHSQLTEtinpVNPNFLSGYSQLAALGNPEQQVYALIAQQITLHAFSIAINEIFWMATLLFVSGL 479
|
....*
gi 1119199301 497 ALIWF 501
Cdd:TIGR00711 480 ILIWF 484
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
28-456 |
1.03e-86 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 271.76 E-value: 1.03e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 28 IGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGL 107
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 108 SGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIa 187
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPI- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 188 aagglgllylmrgqqetvtrspidvvglGLLIVWVGalqimldegrnhdwfaateirvlaviavigfvaflmwelteknP 267
Cdd:cd17503 160 ----------------------------GILALLLA-------------------------------------------P 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 268 IVNLHVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPRLIVS 347
Cdd:cd17503 169 LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 348 VGLLGLGGISAWRVGFTPDITFIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFATSIVQT 427
Cdd:cd17503 249 AGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLAT 328
|
410 420
....*....|....*....|....*....
gi 1119199301 428 GWANATRENQTELASAMTQGQTTLDSMMA 456
Cdd:cd17503 329 LLTNRTQFHHSRLSELLAQQVQKQALIIA 357
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
28-425 |
4.70e-48 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 170.43 E-value: 4.70e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 28 IGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGL 107
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 108 SGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIA 187
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 188 AAGglgllylmrgqqetvtrspidvvglgllivwvgalqimldegrnhdwfaateirvlaviavigfvaflmwelteknp 267
Cdd:cd17321 161 LVA----------------------------------------------------------------------------- 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 268 ivnlhVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPRLIVS 347
Cdd:cd17321 164 -----LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1119199301 348 VGLLGLGGISAWRVGFTPDITFIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFATSIV 425
Cdd:cd17321 239 AGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALL 316
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
23-419 |
4.13e-39 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 145.50 E-value: 4.13e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 23 LAAILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLS 102
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 103 LVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFI 182
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 183 NVPIAAAGGLGLLYLMRGQQETVTRSPIDVVglgllivwvgalqimldegrnhdwfaateirvlaviavigfvaflmwel 262
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRGSL------------------------------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 263 teknpivnLHVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDP 342
Cdd:COG2814 201 --------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1119199301 343 RLIVSVGLLGLGGISAwrvGFTPDITFIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGA 419
Cdd:COG2814 273 RRLLLIGLLLLALGLL---LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
27-358 |
4.70e-33 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 131.39 E-value: 4.70e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 27 LIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCG 106
Cdd:PRK10504 14 IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 107 LSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPI 186
Cdd:PRK10504 94 LSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 187 AAAGGLGLLYLMRGQQETVTRspIDVVGLGLLIVWVGALQIMLDeGRNHDWFAATEIRVLAVIAVIGFVAFLMWELTEKN 266
Cdd:PRK10504 174 GIIGAIATLMLMPNYTMQTRR--FDLSGFLLLAVGMATLTLALD-GSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 267 PIVNLHVFRHRgfvaasiTYSVA-FGAFFASI------VLIPLWLQQNMGYTATWAgyatGIMGILAVISS----PIIGQ 335
Cdd:PRK10504 251 ALFSLKLFRTR-------TFSLGlAGSFAGRIgsgmlpFMTPVFLQIGLGFSPFHA----GLMMIPMVLGSmgmkRIVVQ 319
|
330 340
....*....|....*....|...
gi 1119199301 336 VAARLDPRLIVSVGLLGLGGISA 358
Cdd:PRK10504 320 VVNRFGYRRVLVATTLGLALVSL 342
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
28-424 |
1.45e-32 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 127.29 E-value: 1.45e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 28 IGLGNFLVVLDTTIANVSIPHIAGGLGvSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGL 107
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 108 SGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIA 187
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 188 AAgglgllylmrgqqetvtrspidvvglgllivwvgalqimldegrnhdwfaateirVLAVIavigfvaflmwelteknp 267
Cdd:cd17502 160 GL-------------------------------------------------------ALALL------------------ 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 268 ivnlhvfrhRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLD--PRLI 345
Cdd:cd17502 167 ---------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGryKPLI 237
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1119199301 346 VSVGLLGLGGISAWRVgFTPDITFIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFATSI 424
Cdd:cd17502 238 VIGTILMSVGAGLLTT-LTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| MFS_efflux_LmrB |
NF000060 |
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters ... |
13-424 |
1.26e-30 |
|
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters Lmr(B) expression in Bacillus subtilis and allows Lmr(B) to confer resistance to lincomycin.
Pssm-ID: 411077 [Multi-domain] Cd Length: 479 Bit Score: 124.37 E-value: 1.26e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 13 ARSLRGGKLILAAILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFI 92
Cdd:NF000060 7 AKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLMKELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 93 TSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISD 172
Cdd:NF000060 87 VSLIFSILGTFIAALAPSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTFSGLVLE 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 173 NVGWEWIFFINVPIAAAGGLGLLYLMRGQQETvTRSPIDVVGLGLLIVWVGALQIML-DEGRNHDWFAATEIRVLAVIAV 251
Cdd:NF000060 167 HLNWHWIFWISLPFLVLALVFGIAYMQNVSET-TKPKIDVLSIILSTIGFGGIVFGFsNAGEGSGGWSSPTVIVSLIVGV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 252 IGFVAFLMWELTEKNPIVNLHVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSP 331
Cdd:NF000060 246 VGLILFSIRQLTMKQPMMNLRAFKYPMFILGVIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSP 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 332 IIGQVAARLDPRLIVSVGLLglggISAWRVGFTPDITFIQMAWPMLLTGPFLM----MFFIPVTGLCMASVTTAEQADAA 407
Cdd:NF000060 326 VTGRLFDKYGPKWLVIPGFV----IVTVVLWFFSNVTTTSTAVLIIILHTCLMigisMIMMPAQTNGLNQLPREFYPDGT 401
|
410
....*....|....*..
gi 1119199301 408 GISNFMRTLAGAFATSI 424
Cdd:NF000060 402 AIMNTLQQMAGAIGTAV 418
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
12-304 |
2.17e-28 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 114.52 E-value: 2.17e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 12 AARSLRGGKLILAAILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVF 91
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 92 ITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTIS 171
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 172 DNVGWEWIFFINVPIAAAGGLGLLYLMRGQQETVTRSPIDVVGLGLLIVWVGALQIMLDEGRNHDWFAATEIRVLAVIAV 251
Cdd:COG0477 163 AALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLL 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1119199301 252 IGFVAFLMWELTEKNPIVNLHVFRHRGFVAASITYSVAFGAFFASIVLIPLWL 304
Cdd:COG0477 243 LALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-422 |
4.62e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 111.74 E-value: 4.62e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 28 IGLGNFLVVLDTTIANVSIP-HIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCG 106
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 107 LSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPI 186
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 187 AAAGGLGLLYLMRGQQETVTRSpidvvglgllivwvgalqimldegrnhdwfaateirvlaviavigfvaflmWELTEKN 266
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKP---------------------------------------------------AEEARLS 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 267 PIVNLHVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQnMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPRLIV 346
Cdd:pfam07690 190 LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL 268
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1119199301 347 SVGLLGLGGISAWRVGFTPDITFIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFAT 422
Cdd:pfam07690 269 LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
45-425 |
3.08e-24 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 104.20 E-value: 3.08e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 45 SIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLA 124
Cdd:cd17504 18 ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 125 GGtIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIAaagglgllylmrgqqet 204
Cdd:cd17504 98 GA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA----------------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 205 vtrspidvvglgllivwvgalqimldegrnhdwfaateirVLAVIAVigfvaflmwelteknPIVNLHVFRHRGFVAASI 284
Cdd:cd17504 160 ----------------------------------------VLLAALV---------------PLIDLRLLRRRNVLLANI 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 285 TYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGI----MGILAVISSPIIGQVAARLDPRLIVSVGLLgLGGISAWR 360
Cdd:cd17504 185 TALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLlllpGALVMLIAGPLAGRLIARVGPRRVLLIGLV-ISAVGLLL 263
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1119199301 361 VGFTPDiTFIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFATSIV 425
Cdd:cd17504 264 LALLHS-SLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIA 327
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
26-421 |
1.04e-23 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 102.65 E-value: 1.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 26 ILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVC 105
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 106 GLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDnVGWEWIFFINVP 185
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 186 IAAAGGLGLLYLMRGQQETVTRSPIDVVGLGLLIvwvgalqimldegrnhdwfaateirvlaviavigfvaflmweltek 265
Cdd:cd17474 161 LIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKA---------------------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 266 npivnlhvFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQ-VAARLDPRL 344
Cdd:cd17474 195 --------LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARR 266
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1119199301 345 IVSVGLLGLGGISAWrVGFTPDITFIQMawPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFA 421
Cdd:cd17474 267 ILVIGLLLYALSLLL-LGFVPSLALLLI--AIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-420 |
1.56e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 99.19 E-value: 1.56e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 28 IGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGL 107
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 108 SGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFinvpia 187
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 188 aagglgllylmrgqqetvtrspidVVGLGLLIVWVGALQIMLDEGRNHDWFAATEIRVLAVIAVIGFVAFLmwelteknp 267
Cdd:cd17325 155 ------------------------VCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRL--------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 268 ivnlhvfrhRGFVAASITYSVAFGAFFAsivLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPRLIVS 347
Cdd:cd17325 202 ---------LALFLAIFVLAFAFGALEP---FLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1119199301 348 VGLLgLGGISAWRVGFTPdiTFIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAF 420
Cdd:cd17325 270 IGLL-LSAVALLLLPLAT--SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVL 339
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
26-428 |
8.44e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 96.85 E-value: 8.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 26 ILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVC 105
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 106 GLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVP 185
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 186 IAAAGGLGLLYLMRGQQETVTRSPIDVVGLgllivwvgalqimldegrnhdwfaateirvlaviavigfvaflmweltek 265
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSLGLLSSL-------------------------------------------------- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 266 npivnLHVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPRLI 345
Cdd:cd17324 192 -----LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRAL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 346 VSVGLLglggisawrvgftpdITFIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFATSIV 425
Cdd:cd17324 267 LIALLL---------------LAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAY 331
|
...
gi 1119199301 426 QTG 428
Cdd:cd17324 332 NLG 334
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
25-425 |
3.40e-21 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 95.34 E-value: 3.40e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 25 AILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLV 104
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 105 CGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFInv 184
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 185 pIAAAGGLGLLYLMRGQQETVTRSPIDVVGLGLLIVWvgalqimldegrnhdwfaateirvlaviavigfvaflmwelte 264
Cdd:cd17320 159 -LALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAY------------------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 265 knpivnLHVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPRL 344
Cdd:cd17320 195 ------KRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRR 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 345 IVSVGLLGLGGISAWRVGFTpdiTFIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAG----ISNFMRTLAGAF 420
Cdd:cd17320 269 LLRLGLLLLLAAALVLLLAA---LLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGtasaLLGFLQFLIGAL 345
|
....*
gi 1119199301 421 ATSIV 425
Cdd:cd17320 346 AGALV 350
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-425 |
8.61e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 93.78 E-value: 8.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 23 LAAILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLS 102
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 103 LVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFI 182
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 183 nvpiaaAGGLGLLylmrgqqetvtrspidvvgLGLLIVWVGALQIMLdegrnhdwfaateirvlaviAVIGFVAFLMWel 262
Cdd:COG2271 170 ------LGLPGLL-------------------LALLRFWLLALAYFL--------------------VYFALYGFLTW-- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 263 teknpivnlhvfrhrgfvaasitysvafgaffasivlIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDP 342
Cdd:COG2271 203 -------------------------------------LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 343 R-LIVSVGLLGLGGISAWRVGFTPDITFiqMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFA 421
Cdd:COG2271 246 RrKLVLAIGLLLAALALLLLALLPSPAL--AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALG 323
|
....
gi 1119199301 422 TSIV 425
Cdd:COG2271 324 PLLV 327
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
35-408 |
4.01e-18 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 87.09 E-value: 4.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 35 VVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGML 114
Cdd:PRK14995 18 VAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 115 VAGRIFLGLAGGTIIPLSQTLLLRIFPPEKA-TIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIAAAGGLG 193
Cdd:PRK14995 98 IATRALLAIGAAMIVPATLAGIRATFTEEKQrNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 194 LLYLMRGQQETvTRSPIDVVGLGLLIVWVGALQIMLDEGRnHDWFAATEIRVLAVIAVIGFVAFLMWELTEKNPIVNLHV 273
Cdd:PRK14995 178 TARYVPRQAGR-RDQPLNLGHALMLIVAILLLVYSAKTAL-KGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 274 FRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPRlIVSVGLLGL 353
Cdd:PRK14995 256 FTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLR-LVATGGMAL 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1119199301 354 GGISAWRVGFTPDITFIQMAWP-MLLTGPFLMMFFIPVTGLCMASVtTAEQADAAG 408
Cdd:PRK14995 335 SALSFYGLAMTDFSTQQWQAWGlMALLGFSAASALLASTSAIMAAA-PPEKAAAAG 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
23-421 |
1.08e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 84.93 E-value: 1.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 23 LAAILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLS 102
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 103 LVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFI 182
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 183 nvpiaaagglgllylmrgqqetvtrspidvVGLGLLIVWVGALQIMLDEGRNHDWFAATEIRVLaviavigfvaflmwel 262
Cdd:COG2223 165 ------------------------------LGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ---------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 263 teknpivnLHVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDP 342
Cdd:COG2223 199 --------LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1119199301 343 RLIVSVGLLGLGGISAWRVGFTPDITFIQMAwpMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFA 421
Cdd:COG2223 271 RRVLLIVFALMALGLLLLALALGSLWLFLVL--FLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLG 347
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
26-424 |
1.25e-17 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 85.76 E-value: 1.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 26 ILIGLGNFLVVLDTTIANVSIPHIAGGLGvSSSQASWVITSYAVAEAITVPLTGWLMRRFgGYRVFITSYLAFGVL-SLV 104
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLF-GRRWFFIGGNLLGVVgSIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 105 CGLSGTLGMLVAGRIFLGLAGGTiIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGG--TISDNVGWEWIFFI 182
Cdd:cd06179 79 AGTAKSVNMLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGalVEANAAGWRWIFYI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 183 NVPIAAAGGLGLLYLMR-----GQQETVTRSPI---DVVGLGLLIVWVGALQIMLDEGRNHDWFAATEIRVLAVIAVIGF 254
Cdd:cd06179 158 NAIFNALALILLFFFYHppprpQLHGSSTRQKLkrlDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAHVIAPLVIGGVLL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 255 VAFLMWEL--TEKNPIVNLHVFRHRGFVAASITYSVAFGAFFASIVLIPlwLQQNMGYTATW--AGYATGIMGILAVISS 330
Cdd:cd06179 238 IAFGLYEWkgTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWP--QQISLLFTTDPlkAGLYQLPFGLGTLFGA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 331 PIIGQVAARL-DPR--LIVSVGLLGLGGISAwrVGFTPDITFIQMAWPMLLtgpfLMMFFIPVTgLCMASVT-TAEQAD- 405
Cdd:cd06179 316 ILAGLLLTKIkHIKwqLVAGFVLFTAFLALL--ALITPDNKALAIAFSVLA----GIGIGGPLV-LAIVIVQlSVPPEDi 388
|
410 420
....*....|....*....|.
gi 1119199301 406 --AAGISNFMRTLAGAFATSI 424
Cdd:cd06179 389 gtASGLLGSARALGGAVGTAI 409
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
26-425 |
1.11e-15 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 78.38 E-value: 1.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 26 ILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVC 105
Cdd:cd17319 6 PLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 106 GLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFInvp 185
Cdd:cd17319 86 GFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII--- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 186 iaaagglgllylmrgqqetvtrspIDVVGLGLLIVWvgalqimldegrnhdwfaateirvlaviavigfvaflmweltek 265
Cdd:cd17319 163 ------------------------EGLLGLLLAVLW-------------------------------------------- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 266 npivnlhVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDP--R 343
Cdd:cd17319 175 -------WFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgaR 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 344 LIVSVGLLGLGGISAWRVGFTPDITfIQMAWpMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFATS 423
Cdd:cd17319 248 RLVIIIGLLLAAVGLLLAYLTTSPV-VAVIL-LSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPL 325
|
..
gi 1119199301 424 IV 425
Cdd:cd17319 326 LI 327
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
61-198 |
8.27e-15 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 71.53 E-value: 8.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 61 SWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIF 140
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1119199301 141 PPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIAAAGGLGLLYLM 198
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLL 138
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-425 |
6.03e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 73.23 E-value: 6.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 28 IGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGL 107
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 108 SGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDN--VGWEWIFFINVP 185
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 186 IAAAGGLGLLYLMRGQQETVTRSPIdvvglgllivwvgalqimldegrnhdwfaateirvlaviavigfvaflmWELTEK 265
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNE-------------------------------------------------EASSKS 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 266 NPIVNLHVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPRLI 345
Cdd:cd06174 192 VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 346 VSVGLLGLGGISAwrVGFTPDITFIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFATSIV 425
Cdd:cd06174 272 LLLIGLLLMALGL--ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
26-200 |
9.28e-14 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 72.68 E-value: 9.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 26 ILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVC 105
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 106 GLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKA-TIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINV 184
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRkNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLA 160
|
170
....*....|....*.
gi 1119199301 185 PIAAAGGLGLLYLMRG 200
Cdd:cd17476 161 ILAAIVAVAAIFWTSP 176
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
28-229 |
1.32e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 72.24 E-value: 1.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 28 IGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGL 107
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 108 SGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVpIA 187
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAA-VL 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1119199301 188 AAGGLGLLYLMRGQQETVTRSPIDVVGLGLLIVWVGALQIML 229
Cdd:cd17489 160 ALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPAL 201
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
26-189 |
7.32e-13 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 69.91 E-value: 7.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 26 ILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVC 105
Cdd:cd17323 2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 106 GLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVP 185
Cdd:cd17323 82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161
|
....
gi 1119199301 186 IAAA 189
Cdd:cd17323 162 ISGF 165
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-370 |
9.29e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 69.90 E-value: 9.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 6 SQHENPAARSLRGGKLILAAILIGLGnflVVLDTTIANVS--IPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMR 83
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVA---LNLRPAITSVGplLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 84 RFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFpPEKATIATIIWAMTTTVAPIAG 163
Cdd:COG2807 79 RFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 164 PILGGTISDNVGWEWIFFINVPIAAAGGLGLLYLMRGQQETVTRSPIDVVGlgllivwvgalqimldegrnhdwfaatei 243
Cdd:COG2807 158 AGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASL----------------------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 244 rvlaviavigfvaflmwelteknpivnLHVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNmGYTATWAGYATGIMG 323
Cdd:COG2807 209 ---------------------------RSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQ 260
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1119199301 324 ILAVISSPIIGQVAARLDPRLIVSVGLLGLGGISAWRVGFTPDITFI 370
Cdd:COG2807 261 LAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPW 307
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
26-354 |
5.74e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 67.21 E-value: 5.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 26 ILIGLGNFLVVLDTTIANVSIPHIAGG-LGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLV 104
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 105 CGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDnVGWEWIFfinv 184
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPF---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 185 piaaagglgLLYLMrgqqetvtrsPIDVVGLGLLIVWVGALQIMLDEGRNHDWFAATEIRVLAVIAVIGFVAFLMwelte 264
Cdd:cd17473 157 ---------LVYLL----------ALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLL----- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 265 knpivnlhvfrhrgfvaasitysvafgaFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPRL 344
Cdd:cd17473 213 ----------------------------FYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR 264
|
330
....*....|
gi 1119199301 345 IVSVGLLGLG 354
Cdd:cd17473 265 LLAIGFALMA 274
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-197 |
1.07e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.45 E-value: 1.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 53 LGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLS 132
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1119199301 133 QTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIAAAGGLGLLYL 197
Cdd:cd17325 310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
26-197 |
5.30e-11 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 64.11 E-value: 5.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 26 ILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVC 105
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 106 GL--SGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPP-EKATIATIIWAMT---TTVAPIAGPILggtiSDNVGWEWI 179
Cdd:cd17380 82 PLlaYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVsERSRAVSIVTAGSylgTLLGGLIGPLL----LEYYGWPSV 157
|
170
....*....|....*...
gi 1119199301 180 FFInvpiaaAGGLGLLYL 197
Cdd:cd17380 158 FYF------FGLLGLLWA 169
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
20-396 |
1.28e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 63.33 E-value: 1.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 20 KLILAAILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFG 99
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 100 VLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMtTTVAPIAGPILGGtisdnvgwewi 179
Cdd:COG0738 85 LGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAF-FSLGALLGPLLGG----------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 180 ffinvpiaaagglgllYLMRGQQETVTRSPIDVVGLGLLIVWVGALQIMLDEGRNHDwfaateirvlaviavigfvaflm 259
Cdd:COG0738 153 ----------------LLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEE----------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 260 wELTEKNPIVNLHVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAAR 339
Cdd:COG0738 194 -EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR 272
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1119199301 340 LDPRLIVSVGLLglggisawrvgftpdITFIQMAWPMLLTGPFLMMFFIPVTGLCMA 396
Cdd:COG0738 273 FGPVRLLRLSAL---------------LAAVGLLLALLAPGPWLALIGLALVGLGLS 314
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
50-421 |
4.65e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 61.05 E-value: 4.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 50 AGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTiI 129
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN-V 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 130 PLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFInvpIAAAGGLGLLYLmrgqqetvtrsp 209
Cdd:cd17330 105 SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV---AAALALLNLVLV------------ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 210 idvvglgllivwvgalqimldegrnhdwfaateIRVLAVIAVIGFVAFLMWelteknpivnlhvfrhrgfvaasitysVA 289
Cdd:cd17330 170 ---------------------------------LFFLPPLRRLLLVYFLIA---------------------------LA 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 290 FGAFFASivlIPLWLQQNMGYTATWAGYATGIMGILAVISS-PIIGQVAARLDPRLIVSVGLLgLGGISAWRVGFTPdiT 368
Cdd:cd17330 190 FAGLESV---FSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLL-LAIIGLLLLPFAS--S 263
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1119199301 369 FIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFA 421
Cdd:cd17330 264 VPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIG 316
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
30-456 |
9.01e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 60.71 E-value: 9.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 30 LGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSG 109
Cdd:cd17328 6 LINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 110 TLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISD-NVGWEWIFFInvpiaa 188
Cdd:cd17328 86 NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRV------ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 189 AGGLGLLylmrgqqetvtrspidvvgLGLLIVWVgalqiMLDEGRNHDwfaatEIRVLAVIAVIGFVAfLMWELTeKNPI 268
Cdd:cd17328 160 TGVLGVL-------------------LAILLLLF-----VREPPRGAA-----EGGVMAKSTATSFLA-DLKALA-KNPS 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 269 VNLHVFrhrGFVAASITYSvAFGAFFAS-IVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPR---L 344
Cdd:cd17328 209 FILSTL---GFTAVSFVTG-ALAFWAPTfFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRadpL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 345 IVSVGLLGLGGISAwrVGFTPDITFIQMAWPMLLTGPFLM-MFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFATS 423
Cdd:cd17328 285 VCAVGLLAAAPFLF--LALVLALSNLLLAWVLLFLGEFLLsLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSP 362
|
410 420 430
....*....|....*....|....*....|...
gi 1119199301 424 IVQTGWANATRENQTELASAMTQGQTTLDSMMA 456
Cdd:cd17328 363 YLIGLISDLLRQNKDSPLAEAASLQYALLLCSF 395
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
42-433 |
1.52e-09 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 60.04 E-value: 1.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 42 ANVSI--PHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRI 119
Cdd:TIGR00893 11 ANLSFaaPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYILRV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 120 FLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFI-NVPIAAAGGLGLLYLM 198
Cdd:TIGR00893 91 LLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIeGVLGIIWGVLWLKFIP 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 199 RGQQETVTRSPIDVvglglLIVWVGALQIMLDEGRNHD-----WFAATEIRVLAViavigFVAFLMWELTeknpivnlhv 273
Cdd:TIGR00893 171 DPPQKAKWLTEEEK-----YIVVGGLLAEQQGKGPSTPkkyqiKELLKDRRVWGL-----ALGQFLVNIG---------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 274 frhrgfvaasitySVAFGAFFasivliPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPR---LIVSVGL 350
Cdd:TIGR00893 231 -------------LGFFLTWF------PTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRgksLVFARKT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 351 LGLGGISAWRVGFTPDITFIQMAWPMLLtgpfLMMFFIPVTGLCMASV--TTAEQADAAGISNFMRTLA--GAFATSIVq 426
Cdd:TIGR00893 292 AIIAGLVLSLLMFATNYVNIPYAALALV----ALGFFGLGAGAIGWALisDNAPGNIAGLTGGLINSLGnlGGIVGPIV- 366
|
....*..
gi 1119199301 427 TGWANAT 433
Cdd:TIGR00893 367 IGAIAAT 373
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
25-182 |
2.28e-09 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 59.32 E-value: 2.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 25 AILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLV 104
Cdd:TIGR00710 7 ALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLG 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1119199301 105 CGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFI 182
Cdd:TIGR00710 87 LALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF 164
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
13-197 |
7.48e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 7.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 13 ARSLRGGKLILAAILIGLGNFLvvLDTTIANVSIpHIAGGLGVSSSQASWVITSYAVAEAITVPLTG-WLMRRFGGYRVF 91
Cdd:cd17474 192 KKALRGRGLLTFLVSAFLYFFL--YFAFLTYLPF-LLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRIL 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 92 ITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTIS 171
Cdd:cd17474 269 VIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL 348
|
170 180
....*....|....*....|....*.
gi 1119199301 172 DNVGWEWIFFINVPIAAAGGLGLLYL 197
Cdd:cd17474 349 EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
28-200 |
1.01e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 57.21 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 28 IGLGNFLVVL---DTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLV 104
Cdd:cd17365 1 LALCFLIIVLdgfDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 105 CGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFinv 184
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL--- 157
|
170
....*....|....*.
gi 1119199301 185 pIAAAGGLGLLYLMRG 200
Cdd:cd17365 158 -LGGVPPLILLPLLRG 172
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
25-425 |
1.11e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 56.84 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 25 AILIGLGNFLVVLDTTIANVSIPHIA--GGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLS 102
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAaeFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 103 LVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEK----ATIATIIWAMTTTVAPIAGPILGGTISDNVGWEW 178
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRrgfaLGLLQSGWALGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 179 IFFINvpiaaagglgllylmrgqqetvtrspidvvglgllivwvgalqimldegrnhdwfaateirvlaviAVIGFVAFL 258
Cdd:cd17316 161 LFLIG------------------------------------------------------------------ALPALLALL 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 259 MWelteknpivnlhvfrhRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAA 338
Cdd:cd17316 175 LR----------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 339 RLDPRLIVSVGLLgLGGISAWRVGFTPDITFIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAG 418
Cdd:cd17316 239 RIGRKKTLVIGLI-LSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGG 317
|
....*..
gi 1119199301 419 AFATSIV 425
Cdd:cd17316 318 GGAPPLI 324
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
38-195 |
1.63e-08 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 56.47 E-value: 1.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 38 DTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGL--SGTLGMLV 115
Cdd:cd17318 36 NTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLaaRGGYGALI 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 116 AGRIFLGLAGGTIIPLSQTLLLRIFPP-EKATIATIIWAMTTTVAPIAGPiLGGTISDNVGWEWIFFInvpiaaAGGLGL 194
Cdd:cd17318 116 VLRILQGLAQGVTFPAMHALWAKWAPPlERSRLTSIAYSGSQFGTVIAMP-LSGFLCESLGWPSIFYI------FGGLGL 188
|
.
gi 1119199301 195 L 195
Cdd:cd17318 189 L 189
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
58-198 |
2.03e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 56.06 E-value: 2.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 58 SQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLL 137
Cdd:cd17489 227 SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAV 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1119199301 138 RIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIAAAGGLGLLYLM 198
Cdd:cd17489 307 DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-189 |
2.04e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 56.03 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 21 LILAAILIGLGNFLVvldttiaNVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGV 100
Cdd:cd17477 1 LLLSVALLGLGSGLL-------LPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 101 LSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGtISDNVGWEWIF 180
Cdd:cd17477 74 SVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGALPFL 152
|
....*....
gi 1119199301 181 FINVPIAAA 189
Cdd:cd17477 153 IAAVLLLLA 161
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
45-190 |
3.64e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 55.31 E-value: 3.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 45 SIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLA 124
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1119199301 125 GGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFInvpIAAAG 190
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWV---LALAA 155
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
29-197 |
5.53e-08 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 54.88 E-value: 5.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 29 GLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLS 108
Cdd:cd17359 7 ALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 109 GTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEK-ATIATIIWAMTTT-------VAPIAGPILGGTISDNVGWEWIF 180
Cdd:cd17359 87 PNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIrGRLVSLNQLMIVFgqllayiVNYLIANAGGADWLGAEGWRWML 166
|
170
....*....|....*..
gi 1119199301 181 FINVPIAAAGGLGLLYL 197
Cdd:cd17359 167 GLEAIPAILFLLGMLFI 183
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
6-199 |
1.39e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 53.73 E-value: 1.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 6 SQHENPAARSLRGGKLILAAILIGLGNFLVVLDTTIANVSIP-HIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRR 84
Cdd:cd17473 180 SKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPfLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRR 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 85 FGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGP 164
Cdd:cd17473 260 LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSP 339
|
170 180 190
....*....|....*....|....*....|....*
gi 1119199301 165 ILGGTISDNVGWEWIFFINVPIAAAGGLGLLYLMR 199
Cdd:cd17473 340 LVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
20-428 |
1.58e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 53.51 E-value: 1.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 20 KLILAAILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFG 99
Cdd:TIGR00895 14 YQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 100 VLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWI 179
Cdd:TIGR00895 94 VFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 180 FFINVPIAAaggLGLLYLMRGQQEtvtrsPIDVVGLGLLivwVGALQIMLDEGRNHDWFAATEIRVLAVIAVIGFVAFLM 259
Cdd:TIGR00895 174 FYVGGIAPL---LLLLLLMRFLPE-----SIDFLVSKRP---ETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 260 WeLTEKnpivnlhvfRHRGFVAASITYSVAFGAFFASIVLIPLwLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAAR 339
Cdd:TIGR00895 243 L-FQGK---------TARITVLLWLLYFMLLVGVYFLTNWLPK-LMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 340 LDPRliVSVGLLGLGGISAWRVGFTpditfiqmawpmlLTGPFLMMFFIPVTGLCMasvttaeqadAAGISNFMRTLAGA 419
Cdd:TIGR00895 312 LGPR--VTALLLLLGAVFAVLVGST-------------LFSPTLLLLLGAIAGFFV----------NGGQSGLYALMALF 366
|
....*....
gi 1119199301 420 FATSIVQTG 428
Cdd:TIGR00895 367 YPTAIRATG 375
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
24-182 |
1.60e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 53.42 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 24 AAILIGLgnFLVVLDTTIANVSIP--------HIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSY 95
Cdd:cd17391 200 PSLLISL--FVTTFIIQLANQSIEpiltlyirQLMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 96 LAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVG 175
Cdd:cd17391 278 LASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFG 357
|
....*..
gi 1119199301 176 WEWIFFI 182
Cdd:cd17391 358 YRAVFVV 364
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
30-425 |
2.18e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.00 E-value: 2.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 30 LGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSG 109
Cdd:cd06173 6 LAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 110 TLGM-----LVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINV 184
Cdd:cd06173 86 LLGSlslwlLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 185 PIAAAGGLGLLYLMRGQQETVTRSPIDVVGLGLLIVWvgalqimldegrnhdwfaateirvlaviavigfvaflmwelte 264
Cdd:cd06173 166 LSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLR------------------------------------------- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 265 knpivnlHVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPRL 344
Cdd:cd06173 203 -------YLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 345 IVSVGLLGLgGISAWRVGFTPDITFIQMAwpMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFATSI 424
Cdd:cd06173 276 LLLIGALLL-GLALLVLGLSPSLWLLLAA--LFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352
|
.
gi 1119199301 425 V 425
Cdd:cd06173 353 A 353
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
46-198 |
3.56e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 52.22 E-value: 3.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 46 IPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLM-RRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLA 124
Cdd:cd17490 218 TPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFG 297
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1119199301 125 GGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIAAAGGLGLLYLM 198
Cdd:cd17490 298 TGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
26-425 |
8.55e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.44 E-value: 8.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 26 ILIGLGNFLV-VLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLM----RRFGGYRVFIT-SYLAFG 99
Cdd:COG2211 13 LAYGLGDLGLnLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSdrtrTRWGRRRPWILiGAIPLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 100 VLSLVC------GLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPP--EKATIATIIWAMTTT---VAPIAGPILGG 168
Cdd:COG2211 93 LSFVLLftapdlSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDyeERTRLSSWRFAFAGLgglLASVLPPPLVA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 169 TISDN--VGWEWIFFInvpIAAAGGLGLLYLMRGQQETVTRSPidvvglgllivwvgalqimldegrnhdwfaaTEIRVL 246
Cdd:COG2211 173 AFGGDaaLGYRLTALI---FAVLGLLAFLLTFFGTKERPVPEE-------------------------------EKVSLK 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 247 AVIAVIgfvaflmwelteknpivnlhvFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILA 326
Cdd:COG2211 219 ESLKAL---------------------LKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAA 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 327 VISSPIIGQVAARLDPR--LIVSVGLLGLGGISAWrvgFTPDITFIQMAWPMLLTGPFLMMFFiPVTGLCMASVTTAEQA 404
Cdd:COG2211 278 LLGAPLWPRLAKRFGKKkaFIIGLLLAALGLLLLF---FLGPGNLWLLLVLAALAGIGLGAIL-VLPWAMLADVVDYDEW 353
|
410 420
....*....|....*....|....*....
gi 1119199301 405 D--------AAGISNFMRTLAGAFATSIV 425
Cdd:COG2211 354 KtgrrreglYFGIFTFAIKLGQALAGALA 382
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
27-200 |
9.16e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 51.10 E-value: 9.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 27 LIGLGNFLVVLD-TTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVC 105
Cdd:cd17327 9 LLCILYFLQYLDkSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 106 GLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPIL--GGTISDNV----GWEWI 179
Cdd:cd17327 89 AAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLayGVFKILGVgglaGWRWL 168
|
170 180
....*....|....*....|.
gi 1119199301 180 FFINVPIAAAGGLGLLYLMRG 200
Cdd:cd17327 169 FIIEGLITIIIGLVIFFWLPD 189
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
26-199 |
1.75e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 50.24 E-value: 1.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 26 ILIGLGNFL-VVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLV 104
Cdd:COG0738 213 LLGGLAIFLyVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 105 CGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIwAMTTTVAPIAGPILGGTISDNVGWEWIFFINV 184
Cdd:COG0738 293 ALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAV-LIMGIVGGAIGPPLIGFLADAFGLRAAFLVPL 371
|
170
....*....|....*
gi 1119199301 185 PIAAAGGLGLLYLMR 199
Cdd:COG0738 372 VCYLLILLLALALKR 386
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
43-199 |
1.83e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.96 E-value: 1.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 43 NVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLG 122
Cdd:cd17312 23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1119199301 123 LAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIAAAGGLGLLYLMR 199
Cdd:cd17312 103 LFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLR 179
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
21-201 |
2.64e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.51 E-value: 2.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 21 LILAAILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGV 100
Cdd:cd17365 169 LLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAV 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 101 LSLVCGLSGTLGMLVAGRIFL-GLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGT-ISDNVGWEW 178
Cdd:cd17365 249 SLALLGVSPASLVLLYVLVFLaGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLlLAAGLGPES 328
|
170 180
....*....|....*....|...
gi 1119199301 179 IFFINVPIAAAGGLGLLYLMRGQ 201
Cdd:cd17365 329 VFLALAIPAALGALAVLLLRLRR 351
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
39-199 |
3.45e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 49.17 E-value: 3.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 39 TTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGT-LGMLVAG 117
Cdd:cd17341 15 WFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSsYWGLLVL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 118 RIFLGLAGGTIIPlSQTLLLRIFPPEKATIATIIWA----MTTTVAPIAGPILGGTIS---DNVGWEWIFFINVPIAAAG 190
Cdd:cd17341 95 GFLLGFAGANFAS-GQPWASFWFPKEKIGGAAGGIAgagnMGVAVSQLLAPLIAGAIVfdgGFVGWRNAFFVPGILLAIA 173
|
....*....
gi 1119199301 191 GLGLLYLMR 199
Cdd:cd17341 174 AVLVLLFGD 182
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
30-197 |
4.67e-06 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 48.72 E-value: 4.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 30 LGNFLVVLDTTIANVSIPHIA--GGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGL 107
Cdd:cd17315 4 LGGLLFGYDLGVINGALLYIAkdLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 108 SGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDN--VGWEWIFFINVP 185
Cdd:cd17315 84 APNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSppGWWRLMFALAAV 163
|
170
....*....|..
gi 1119199301 186 IAAAGGLGLLYL 197
Cdd:cd17315 164 PALLQLLLMFFL 175
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
53-210 |
5.21e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 48.76 E-value: 5.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 53 LGVSSSQASWVITSYAVAE-AITVPLtGWLMRRFGGYRVFITSYLAFGVL-SLVCGLSGTLGMLVAGRIFLGLAGGTIIP 130
Cdd:cd17490 26 LGASLSMIGIILGAYGISQmLLRIPL-GILSDRIGKRKLFIIIGLLFTVLaSLIMILFPSPWGLLIARFLSGIAAATWVS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 131 LSqTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINvpiAAAGGLGLLYLMRGQQETVTRSPI 210
Cdd:cd17490 105 FT-VLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLA---ALAGVLGFILSLFIKEERREKKPV 180
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
26-199 |
5.64e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 48.32 E-value: 5.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 26 ILIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWL--MRRFGGYRVFITSYLAFGVLSL 103
Cdd:cd17352 186 VLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLadKPRIGRLYLYIFTLLILGLSLL 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 104 VCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFIN 183
Cdd:cd17352 266 AFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYF 345
|
170
....*....|....*.
gi 1119199301 184 VPIAAAGGLGLLYLMR 199
Cdd:cd17352 346 CGACLLLSGVLLFLLP 361
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
45-300 |
8.31e-06 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 48.51 E-value: 8.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 45 SIPHIAGGLGVSSSQaSWVITSYAVAEAITVPLTGWLMRRFGgYRVFITSYLAFGVLSLVCGLSGT-LGMLVAGRIFLGL 123
Cdd:pfam06609 66 ALPNILQDIGQSENQ-GLFSTLWTMGQAVSILMMGRLTDRFG-RRPFVIATHIIGLVGAIVGCTANkFNTLLAAMTLLGV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 124 AGGtiiPLSQTLLL--RIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVpIAAAGGLGLLYL---- 197
Cdd:pfam06609 144 AAG---PAGASPLFigELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYI-IMSAIAVLLIIIwyhp 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 198 -----MRGQQETVTRSPIDVVGLGLLIVWVGALQIMLD---EGRNHDWFAATEIRVLAVIAVIGFVAFLMWELTEK--NP 267
Cdd:pfam06609 220 psfaqLHGKKARKRDELAKLDWIGIFLVIAGTSLFLLGvswGGKPNNPWNSAKIIGLISSGAGSLVIFALYEVFGKpeQP 299
|
250 260 270
....*....|....*....|....*....|....
gi 1119199301 268 IVNLHVFRH-RGFVAASITYSVaFGAFFASIVLI 300
Cdd:pfam06609 300 IIPPALFKDtRGFVCILIISSI-MGAMHLCLTII 332
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
16-195 |
8.54e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.93 E-value: 8.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 16 LRGGKLILAAILIGLGNF-LVVLDTTIAnvsiPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITS 94
Cdd:cd17324 195 LRNPRLRLAYLITFLLFGgFFALYTYLA----PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIAL 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 95 YLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIwaMTTTVAPIA-GPILGGTISDN 173
Cdd:cd17324 271 LLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLY--LAAYNLGGAlGAALGGLVLDH 348
|
170 180
....*....|....*....|..
gi 1119199301 174 VGWEWIFFInvpIAAAGGLGLL 195
Cdd:cd17324 349 GGWAGVGWV---GAALLLLALL 367
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
53-198 |
9.86e-06 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 47.73 E-value: 9.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 53 LGVSSSQASWVITSYAVAEAITVPLTGWLMRRF--GGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIP 130
Cdd:cd17396 233 AGMGEAESLKLISYYSMGSLVCVFITAVLLKRYvrPIWILVLYPIISLLALFVLYLVPSPDVCILGAFVIGFFAAGGVLQ 312
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1119199301 131 LSQTLLLRIFPPEKATIaTIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIAAAGGLGLLYLM 198
Cdd:cd17396 313 LGLTLMAEFFPKGKGKV-TGIYMIASSLANFVIPLITGIIASAIGIAYIFLFDFGIALLGLLLAIFVF 379
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
19-197 |
1.02e-05 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 48.10 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 19 GKLILAAILIGLGNFLVVLDTTIANVSIPHIAG--------GLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRV 90
Cdd:TIGR00879 24 WKVALLSLIAAIGGLMFGYDTGVIGGALALPAFefkftsanSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 91 FITSYLAF---GVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPE-KATIATIIWAMTTTVAPIAGPIL 166
Cdd:TIGR00879 104 LLIIALLFvigAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKAlRGALTSLYQLAITFGILVAYGFG 183
|
170 180 190
....*....|....*....|....*....|...
gi 1119199301 167 GGTISDN--VGWEWIFFINVPIAAAGGLGLLYL 197
Cdd:TIGR00879 184 SGKVSLNntLGWRIPLGLQLIPAGLLFLGLFFL 216
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-199 |
1.24e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 47.56 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 6 SQHENPAARSLRGGKLILAAILIGLGNFLvvldTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRF 85
Cdd:COG2807 202 APAAASLRSLWRSPLAWLLTLFFGLQSLL----YYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 86 GGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTT-TVAPIAGP 164
Cdd:COG2807 278 GDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVgYLLAALGP 357
|
170 180 190
....*....|....*....|....*....|....*.
gi 1119199301 165 ILGGTISDNVG-WEWIFFINVPIAAAGGLGLLYLMR 199
Cdd:COG2807 358 LLVGALHDATGsWTAALLLLAALAVLMLVAGLLAGR 393
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
40-199 |
1.47e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 47.18 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 40 TIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGL-SGTLGMLVAGR 118
Cdd:COG2223 223 GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALaLGSLWLFLVLF 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 119 IFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVG-WEWIFFINVPIAAAGGLGLLYL 197
Cdd:COG2223 303 LLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLL 382
|
..
gi 1119199301 198 MR 199
Cdd:COG2223 383 YR 384
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
16-197 |
1.78e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 16 LRGGKLILAAILIGLGNFLVVLDTTIAnvsIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSY 95
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLL---PLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 96 LAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVG 175
Cdd:cd06173 282 LLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG 361
|
170 180
....*....|....*....|..
gi 1119199301 176 WEWIFFINVPIAAAGGLGLLYL 197
Cdd:cd06173 362 LSAVFLLAGALLLLAALLLLLL 383
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
28-197 |
2.22e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 46.88 E-value: 2.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 28 IGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITS---YLAFGVLSLV 104
Cdd:pfam00083 16 TGVIGAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIAnvlFVIGAVLQGA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 105 CGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILG---GTISDNVGWEWIFF 181
Cdd:pfam00083 96 AKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLG 175
|
170
....*....|....*.
gi 1119199301 182 INVPIAAAGGLGLLYL 197
Cdd:pfam00083 176 LQLVPALLLIIGLLFL 191
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
20-175 |
2.53e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.82 E-value: 2.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 20 KLILAAILIGLGNFLVvldttiANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFG 99
Cdd:COG2211 232 LLLLAYLLFFLALALV------AALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 100 VLSLVCGLSG--TLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKAT-------IATIIWAMTTTVAPIAGPILGGTI 170
Cdd:COG2211 306 LGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGALAGLL 385
|
....*
gi 1119199301 171 SDNVG 175
Cdd:COG2211 386 LALFG 390
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
68-431 |
2.65e-05 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 46.92 E-value: 2.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 68 AVAEAITVPLTGwLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGlAGGTIIPLSQTLLLrifppekATI 147
Cdd:cd17322 48 IVSAVSQPPYAK-LSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYN-AGYTGLNLLLTLIL-------ADF 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 148 ATIIWAMTTTVAP----IAGPILGGTISD----NVGWEW---IFFINVPIAAAGGLGLLYLMRGQ------------QET 204
Cdd:cd17322 119 SSLKNRGFASAIPslpyIITTWIGGNIAQaalpNSNWRWgygMWAIILPLSSLPLVLCLLYMQRKarkdgeikelknQET 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 205 VTRSP------------IDVVGLGLLIVWVGA--LQIMLDEGRNHDWFAATEIRVLaVIAVIGFVAFLMWELT-EKNPIV 269
Cdd:cd17322 199 EEQTGglsqnlvklfwkLDIFGVILLTAGLGLilVPLTLAGGAKSKWKNSSIIAMI-VLGGVLLVAFLLWEAKfAKYPFL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 270 NLHVFRHRGFVAASITYSVAFGAFFASIVLIPLWLQQNMGYTATWAGYATGIMGILAVISSPIIG---QVAARLDPRLI- 345
Cdd:cd17322 278 PFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGfliRKTRRYKVLVIi 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 346 -VSVGLLGLGGISAWRVGFTPDITFIqmaWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFATSI 424
Cdd:cd17322 358 gVPLYIVGMGLLIRYRGGSGSHGGII---GALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAI 434
|
....*..
gi 1119199301 425 VQTGWAN 431
Cdd:cd17322 435 SGAIWTQ 441
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
46-189 |
5.78e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 45.30 E-value: 5.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 46 IPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAG 125
Cdd:cd17390 19 LSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFK 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1119199301 126 GTiIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTIsdnVGWEWIFFINVPIAAA 189
Cdd:cd17390 99 HT-QSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHL---AETDGGFYYVALLCSA 158
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
44-204 |
6.02e-05 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 45.40 E-value: 6.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 44 VSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGL 123
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 124 AGGTIIPLSQTLLLRIFPPEK-ATIATIIWAMTTTVaPIAGPILGGTISDNVGWEWIFFInvpIAAAGGLGLLYLMRGQQ 202
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRrAKVLSLLNGITCII-PVLAPVLGHLIMLKFPWQSLFYT---MAAMGILVLLLSLFILK 179
|
..
gi 1119199301 203 ET 204
Cdd:PRK10473 180 ET 181
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
30-211 |
6.59e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 45.06 E-value: 6.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 30 LGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSG 109
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 110 TLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVA-PIAGPILGGTISDNVGWEWIFFINVPIAA 188
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGgGLLPPLVLFGIAELYSWHWVFIVPGIIAI 161
|
170 180
....*....|....*....|...
gi 1119199301 189 AGGLGLLYLMRGQQETVTRSPID 211
Cdd:TIGR00881 162 IVSLICFLLLRDSPQSCGLPPAE 184
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
49-199 |
7.36e-05 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 45.27 E-value: 7.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 49 IAGGLGVSSSQASWVITSYA-VAEAITVPLTgWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGT 127
Cdd:PRK03545 35 IAQSFHMQTAQVGLMLTIYAwVVALMSLPLM-LLTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFAHAI 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1119199301 128 IIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFInvpIAAAGGLGLLYLMR 199
Cdd:PRK03545 114 FWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLA---IGGGALITLLLLIK 182
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
3-195 |
8.88e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.85 E-value: 8.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 3 DSISQHENPAARSLRGGKLILAAILIGLGNFLVVLDTTIANVSIP-HIAGGLGVSSSQASWVITSYAVAEAITVPLTGWL 81
Cdd:cd17471 179 VKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPlYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 82 MRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFpPEKATIATIIWAMTTTVAPI 161
Cdd:cd17471 259 AKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLM-PGQPGLATTLYSNASRIGSL 337
|
170 180 190
....*....|....*....|....*....|....
gi 1119199301 162 AGPILGGTISDNVGWEWIFFINVPIAAAGGLGLL 195
Cdd:cd17471 338 LGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
44-192 |
1.45e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 44.15 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 44 VSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGL 123
Cdd:cd17475 17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1119199301 124 AGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIAAAGGL 192
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAV 165
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
27-197 |
2.45e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.41 E-value: 2.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 27 LIGLGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYL--AFGVLSLV 104
Cdd:cd17355 214 LLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYAlrALGLALLL 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 105 CGLSGTLGMLVAGrIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVG-WEWIFFIN 183
Cdd:cd17355 294 LLPFPPLALLLFA-ALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALA 372
|
170
....*....|....
gi 1119199301 184 VPIAAAGGLGLLYL 197
Cdd:cd17355 373 VALGLIAALLVLPI 386
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
20-195 |
3.38e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 20 KLILAAILIGLGNFLVVLdttianvsIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFG 99
Cdd:cd17370 204 LYLLAVALFALGNFSFAF--------LILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 100 VLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWI 179
Cdd:cd17370 276 LAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAA 355
|
170
....*....|....*.
gi 1119199301 180 FFINVPIAAAGGLGLL 195
Cdd:cd17370 356 FLFSAVLALIALLLLL 371
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
53-195 |
4.07e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 4.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 53 LGVSSSQASWVITSYAVAEAITVPLTGWLMRR-FGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPL 131
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPL 313
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1119199301 132 SQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNV-GWEWIFFINVPIAAAGGLGLL 195
Cdd:cd06174 314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATfGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
54-171 |
4.97e-04 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 42.68 E-value: 4.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 54 GVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITS-----YLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTI 128
Cdd:cd17322 317 GESITSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLVIIgvplyIVGMGLLIRYRGGSGSHGGIIGALILIGIGGGLF 396
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1119199301 129 IPLSQTLLLRIFPPEKATIATiiwAMTTTVAPIAGPIlGGTIS 171
Cdd:cd17322 397 TYPVQVSVQASVSHQEMAVVT---ALLLTVYSIGGAV-GAAIS 435
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
21-220 |
6.38e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.21 E-value: 6.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 21 LILAAILIGLGNFLVVLDTTIanvsipHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGV 100
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAI------YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 101 LSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNvGWEWIF 180
Cdd:cd17329 78 GFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLF 156
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1119199301 181 FINVPIAAAGGLGLLYLMRGQQETVTRSPIDVVGLGLLIV 220
Cdd:cd17329 157 LAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIV 196
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
40-175 |
7.71e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 42.06 E-value: 7.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 40 TIANVSIPHIAGGLGVSSSQaswVITSYAVAEAITVP---LTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVA 116
Cdd:COG2270 256 TVIAFAGIYAAGVLGFSTTE---LIVFGLLVQIVAALgalLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWI 332
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1119199301 117 GRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVG 175
Cdd:COG2270 333 LGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTG 391
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
72-351 |
1.09e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 41.44 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 72 AITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGtIIPLSQTLLLRIFPPEKATIATII 151
Cdd:PRK09874 68 AIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGG-FVPNANALIATQVPRNKSGWALGT 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 152 WAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIAAAGGLGLLYLMRGQQETVTRSPIdvvglgllivwvgalqimlde 231
Cdd:PRK09874 147 LSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPVSKKEM--------------------- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 232 grnhdwfaateIRVLAVIAVIgfvaflmwelteKNPIVNLHVFrhrgfvAASITYSVAFGAFFASIVLIPLWLQQNMGYT 311
Cdd:PRK09874 206 -----------LHMREVVTSL------------KNPKLVLSLF------VTTLIIQVATGSIAPILTLYVRELAGNVSNI 256
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1119199301 312 ATWAGYATGIMGILAVISSPIIGQVAARLDPRLIVSVGLL 351
Cdd:PRK09874 257 AFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALI 296
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
46-199 |
1.15e-03 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 41.23 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 46 IPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAG 125
Cdd:PRK10091 26 LTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPH 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1119199301 126 GTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFInvpIAAAGGLGLLYLMR 199
Cdd:PRK10091 106 GAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLL---IAVFNIAVLASIYF 176
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
44-128 |
1.24e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 41.09 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 44 VSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGL 123
Cdd:cd17393 20 TRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGA 99
|
....*
gi 1119199301 124 AGGTI 128
Cdd:cd17393 100 ANGAL 104
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
290-409 |
1.77e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.66 E-value: 1.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 290 FGAFFASIVLIPLWLQQnMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPRLIVSVGLLglggisawrvgftpdITF 369
Cdd:cd17489 9 FLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLL---------------IFA 72
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1119199301 370 IQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGI 409
Cdd:cd17489 73 LATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADI 112
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
30-184 |
2.00e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 40.36 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 30 LGNFLVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSG 109
Cdd:cd17371 6 LGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1119199301 110 TLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPE-KATIATII---WAMTTTVAPIAGPILGGTISDNVGWEWIFFINV 184
Cdd:cd17371 86 NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARhRGKALGYVqsgWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGA 164
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
28-200 |
2.29e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 40.31 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 28 IGLGNFLVVLDTTIANVsiphiAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGL 107
Cdd:cd17388 13 MGIGLIMPVLPTLLREF-----VGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 108 SGTLGMLVAGRIFLGLAGGTIIPLSQTlLLRIFPPEKATIATIIWAMTTTVAPIAGPILGgtisdnvGWEWIFFINVPIA 187
Cdd:cd17388 88 APTLWWLYLGRIIAGITGATGAVAAAY-IADVTPPEQRARNFGLLGAAFGLGFIAGPALG-------GLLGEISPRAPFL 159
|
170
....*....|...
gi 1119199301 188 AAGGLGLLYLMRG 200
Cdd:cd17388 160 VAAGLNGLNFLLG 172
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
53-199 |
2.36e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.33 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 53 LGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGL--AGGTIIP 130
Cdd:cd17355 33 FGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGggAGTLAAV 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1119199301 131 LSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTIsDNVGWEWIFFINVPIAAAGGLGLLYLMR 199
Cdd:cd17355 113 AFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALI-EAFGWRTALLVLALLALLVLVPVLLLLR 180
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
37-130 |
2.61e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 40.33 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 37 LDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVA 116
Cdd:PRK11551 29 LDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLV 108
|
90
....*....|....
gi 1119199301 117 GRIFLGLAGGTIIP 130
Cdd:PRK11551 109 ARLLTGVGLGGALP 122
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
54-192 |
3.17e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.85 E-value: 3.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 54 GVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLA---FGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIP 130
Cdd:cd17478 226 GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLaapFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVV 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1119199301 131 LSQTLLlrifPPEKATIATIIWAMTTTVAPIAGPILGGtISDNVGWEWIFFINVPIAAAGGL 192
Cdd:cd17478 306 LAQELL----PGNVGLASGLMMGLSFGLGGIGAPVLGA-LADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
59-151 |
3.60e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.49 E-value: 3.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 59 QASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLR 138
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90
....*....|...
gi 1119199301 139 IFPPEKATIATII 151
Cdd:cd17317 106 IVGPKYRSFVGIL 118
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
21-174 |
4.22e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.48 E-value: 4.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 21 LILAAILIGLGNFLVVLdTTIANVSIPHiAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGV 100
Cdd:cd17504 182 ANITALLAGFGMFMVFQ-LLPQLLQLPT-PTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAV 259
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1119199301 101 -LSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNV 174
Cdd:cd17504 260 gLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTY 334
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
4-167 |
4.64e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.23 E-value: 4.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 4 SISQHENPAARSLRGGKLILAAILIGLGnflVVLDTTIANVSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMR 83
Cdd:cd17333 184 SVGAFSASASRLLRNPSIILGALALFLY---VGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 84 RFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGLAGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAG 163
Cdd:cd17333 261 RIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIP 340
|
....
gi 1119199301 164 PILG 167
Cdd:cd17333 341 FIMG 344
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
44-195 |
7.84e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.46 E-value: 7.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 44 VSIPHIAGGLGVSSSQASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLVCGLSGTLGMLVAGRIFLGL 123
Cdd:cd17333 17 ILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGL 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1119199301 124 AGGTIIPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFINVPIAAAGGLGLL 195
Cdd:cd17333 97 GAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILIL 168
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
274-425 |
8.91e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.31 E-value: 8.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 274 FRHRGFVAASITYSVAFGAFFASIVLIPLwLQQNMGYTATWAGYATGIMGILAVISSPIIGQVAARLDPRLIVSVGLLGL 353
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPP-LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1119199301 354 GGISAWrVGFTPdiTFIQMAWPMLLTGPFLMMFFIPVTGLCMASVTTAEQADAAGISNFMRTLAGAFATSIV 425
Cdd:COG2271 86 GLATLL-FGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
30-182 |
9.41e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.40 E-value: 9.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119199301 30 LGNFLVVLDTTIANVSIPHIAGGLGVSSSQ-----ASWVITSYAVAEAITVPLTGWLMRRFGGYRVFITSYLAFGVLSLV 104
Cdd:cd17391 3 LGNFFTGIGFSLIAPFLPLYIEQLGVTSGGlvelwSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGL 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1119199301 105 CGLSGTLGMLVAGRIFLGLAGGTIiPLSQTLLLRIFPPEKATIATIIWAMTTTVAPIAGPILGGTISDNVGWEWIFFI 182
Cdd:cd17391 83 MAFVTNVWQLLILRLLQGVFSGYV-PNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI 159
|
|
| |
