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Conserved domains on  [gi|1115564989|ref|WP_072132889|]
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hypothetical protein, partial [Escherichia coli]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
McrB super family cl34253
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
12-331 7.71e-21

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


The actual alignment was detected with superfamily member COG1401:

Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 94.45  E-value: 7.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989  12 FRAQIEKNNQYNSVWGKHYRQLVEQIQAEKPNFSEATI--RQVWYERDNGVSSLMQGGMSLVEFENAQKDLLTLTRQIAE 89
Cdd:COG1401     8 FKFLIVGLRLKPLESEDAVRELGIRADDLRGAAELATRlaERLSEELLRADRAARATELVEELSAALEVVVLLLDLEKVE 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989  90 ECTQENYNRVIERLIKLKADGVLNKVYRALCNR-AFAAIYPSKISSVVNVNNFFSCYNYCNNHFQLGLSGEREWLARNVD 168
Cdd:COG1401    88 LNEKLALSEAAVAIEELYELEADSEIEAVGLLLeLAERSDALEALERARLLLELADLEERAALETEVLEALEAELEELLA 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989 169 LKETLNRALGDDIDPIELNMSLWHLYAYEIQDKNAIglvgseSALQENEQEDDVISSPLPKNTILYGPPGTGKTYRTIEI 248
Cdd:COG1401   168 APEDLSADALAAELSAAEELYSEDLESEDDYLKDLL------REKFEETLEAFLAALKTKKNVILAGPPGTGKTYLARRL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989 249 AVQICDPiayslqegkdesekrrelkkiydqliKDNRVRFITFHQSFGYEEFIEGLRAETTDDgnvKYEIKAGIFKQICE 328
Cdd:COG1401   242 AEALGGE--------------------------DNGRIEFVQFHPSWSYEDFLLGYRPSLDEG---KYEPTPGIFLRFCL 292

                  ...
gi 1115564989 329 DAA 331
Cdd:COG1401   293 KAE 295
 
Name Accession Description Interval E-value
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
12-331 7.71e-21

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 94.45  E-value: 7.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989  12 FRAQIEKNNQYNSVWGKHYRQLVEQIQAEKPNFSEATI--RQVWYERDNGVSSLMQGGMSLVEFENAQKDLLTLTRQIAE 89
Cdd:COG1401     8 FKFLIVGLRLKPLESEDAVRELGIRADDLRGAAELATRlaERLSEELLRADRAARATELVEELSAALEVVVLLLDLEKVE 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989  90 ECTQENYNRVIERLIKLKADGVLNKVYRALCNR-AFAAIYPSKISSVVNVNNFFSCYNYCNNHFQLGLSGEREWLARNVD 168
Cdd:COG1401    88 LNEKLALSEAAVAIEELYELEADSEIEAVGLLLeLAERSDALEALERARLLLELADLEERAALETEVLEALEAELEELLA 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989 169 LKETLNRALGDDIDPIELNMSLWHLYAYEIQDKNAIglvgseSALQENEQEDDVISSPLPKNTILYGPPGTGKTYRTIEI 248
Cdd:COG1401   168 APEDLSADALAAELSAAEELYSEDLESEDDYLKDLL------REKFEETLEAFLAALKTKKNVILAGPPGTGKTYLARRL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989 249 AVQICDPiayslqegkdesekrrelkkiydqliKDNRVRFITFHQSFGYEEFIEGLRAETTDDgnvKYEIKAGIFKQICE 328
Cdd:COG1401   242 AEALGGE--------------------------DNGRIEFVQFHPSWSYEDFLLGYRPSLDEG---KYEPTPGIFLRFCL 292

                  ...
gi 1115564989 329 DAA 331
Cdd:COG1401   293 KAE 295
PRK11331 PRK11331
5-methylcytosine-specific restriction enzyme subunit McrB; Provisional
227-330 1.26e-06

5-methylcytosine-specific restriction enzyme subunit McrB; Provisional


Pssm-ID: 183088 [Multi-domain]  Cd Length: 459  Bit Score: 50.47  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989 227 LPKNTILYGPPGTGKTYrtieiavqICDPIAYSLQEGKdesekrrelkkiydqliKDNRVRFITFHQSFGYEEFIEGLRA 306
Cdd:PRK11331  193 IKKNIILQGPPGVGKTF--------VARRLAYLLTGEK-----------------APQRVNMVQFHQSYSYEDFIQGYRP 247
                          90       100
                  ....*....|....*....|....
gi 1115564989 307 EttddgNVKYEIKAGIFKQICEDA 330
Cdd:PRK11331  248 N-----GVGFRRKDGIFYNFCQQA 266
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
225-243 1.90e-03

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 38.80  E-value: 1.90e-03
                          10
                  ....*....|....*....
gi 1115564989 225 SPLPKNTILYGPPGTGKTY 243
Cdd:cd19481    23 LGLPKGILLYGPPGTGKTL 41
 
Name Accession Description Interval E-value
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
12-331 7.71e-21

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 94.45  E-value: 7.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989  12 FRAQIEKNNQYNSVWGKHYRQLVEQIQAEKPNFSEATI--RQVWYERDNGVSSLMQGGMSLVEFENAQKDLLTLTRQIAE 89
Cdd:COG1401     8 FKFLIVGLRLKPLESEDAVRELGIRADDLRGAAELATRlaERLSEELLRADRAARATELVEELSAALEVVVLLLDLEKVE 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989  90 ECTQENYNRVIERLIKLKADGVLNKVYRALCNR-AFAAIYPSKISSVVNVNNFFSCYNYCNNHFQLGLSGEREWLARNVD 168
Cdd:COG1401    88 LNEKLALSEAAVAIEELYELEADSEIEAVGLLLeLAERSDALEALERARLLLELADLEERAALETEVLEALEAELEELLA 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989 169 LKETLNRALGDDIDPIELNMSLWHLYAYEIQDKNAIglvgseSALQENEQEDDVISSPLPKNTILYGPPGTGKTYRTIEI 248
Cdd:COG1401   168 APEDLSADALAAELSAAEELYSEDLESEDDYLKDLL------REKFEETLEAFLAALKTKKNVILAGPPGTGKTYLARRL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989 249 AVQICDPiayslqegkdesekrrelkkiydqliKDNRVRFITFHQSFGYEEFIEGLRAETTDDgnvKYEIKAGIFKQICE 328
Cdd:COG1401   242 AEALGGE--------------------------DNGRIEFVQFHPSWSYEDFLLGYRPSLDEG---KYEPTPGIFLRFCL 292

                  ...
gi 1115564989 329 DAA 331
Cdd:COG1401   293 KAE 295
PRK11331 PRK11331
5-methylcytosine-specific restriction enzyme subunit McrB; Provisional
227-330 1.26e-06

5-methylcytosine-specific restriction enzyme subunit McrB; Provisional


Pssm-ID: 183088 [Multi-domain]  Cd Length: 459  Bit Score: 50.47  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989 227 LPKNTILYGPPGTGKTYrtieiavqICDPIAYSLQEGKdesekrrelkkiydqliKDNRVRFITFHQSFGYEEFIEGLRA 306
Cdd:PRK11331  193 IKKNIILQGPPGVGKTF--------VARRLAYLLTGEK-----------------APQRVNMVQFHQSYSYEDFIQGYRP 247
                          90       100
                  ....*....|....*....|....
gi 1115564989 307 EttddgNVKYEIKAGIFKQICEDA 330
Cdd:PRK11331  248 N-----GVGFRRKDGIFYNFCQQA 266
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
225-243 1.90e-03

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 38.80  E-value: 1.90e-03
                          10
                  ....*....|....*....
gi 1115564989 225 SPLPKNTILYGPPGTGKTY 243
Cdd:cd19481    23 LGLPKGILLYGPPGTGKTL 41
DEXXQc_SF1 cd18043
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are ...
217-277 2.43e-03

DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along with the concomitant unwinding of DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination, and repair as well as many aspects of RNA metabolism. Superfamily 1 helicases are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350801 [Multi-domain]  Cd Length: 127  Bit Score: 37.95  E-value: 2.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1115564989 217 EQEDDVISSPLPKNTILYGPPGTGKTYrtiEIAVQICDPIAyslqEGKD---ESEKRRELKKIY 277
Cdd:cd18043     3 SQEAAIISARNGKNVVIQGPPGTGKSQ---TIANIIANALA----RGKRvlfVSEKKAALDVVR 59
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
220-312 2.77e-03

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 39.13  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1115564989 220 DDVISSPLPK--NTILYGPPGTGKTyrtiEIAVQIcdpIAYSLQEGK-------DESEK--RRELKKI---YDQLIKDNR 285
Cdd:COG0467    10 DELLGGGLPRgsSTLLSGPPGTGKT----TLALQF---LAEGLRRGEkglyvsfEESPEqlLRRAESLgldLEEYIESGL 82
                          90       100       110
                  ....*....|....*....|....*....|
gi 1115564989 286 VRFI---TFHQSFGYEEFIEGLRAETTDDG 312
Cdd:COG0467    83 LRIIdlsPEELGLDLEELLARLREAVEEFG 112
DEXXQc_Mov10L1 cd18078
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds ...
226-252 4.24e-03

DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. Mov10L1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350836 [Multi-domain]  Cd Length: 230  Bit Score: 38.50  E-value: 4.24e-03
                          10        20
                  ....*....|....*....|....*..
gi 1115564989 226 PLPknTILYGPPGTGKTYRTIEIAVQI 252
Cdd:cd18078    20 PLP--YILFGPPGTGKTVTIIEAILQV 44
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
214-249 6.13e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 37.13  E-value: 6.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1115564989 214 QENEQEDDVISSPLPKNTILYGPPGTGKTYRTIEIA 249
Cdd:cd00009     5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIA 40
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
177-242 6.23e-03

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 38.60  E-value: 6.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1115564989 177 LGDDIDPIELNMSL----WHLYA------YEIQD-KNAIglvgsESALQENEQEDDVISSPlPKNTILYGPPGTGKT 242
Cdd:PTZ00361  161 LLDEVDPLVSVMKVdkapLESYAdiggleQQIQEiKEAV-----ELPLTHPELYDDIGIKP-PKGVILYGPPGTGKT 231
DEXXQc_Helz-like cd18038
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ...
232-253 6.52e-03

DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350796 [Multi-domain]  Cd Length: 229  Bit Score: 37.98  E-value: 6.52e-03
                          10        20
                  ....*....|....*....|..
gi 1115564989 232 ILYGPPGTGKTYRTIEIAVQIC 253
Cdd:cd18038    24 IIFGPPGTGKTVTLVEAILQVL 45
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
207-242 7.47e-03

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 37.21  E-value: 7.47e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1115564989 207 VGSESALQENEQEDDVISSP---------LPKNTILYGPPGTGKT 242
Cdd:cd19501     7 AGCEEAKEELKEVVEFLKNPekftklgakIPKGVLLVGPPGTGKT 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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