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Conserved domains on  [gi|1092709503|ref|WP_070639890|]
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anti-sigma factor antagonist [Olsenella sp. HMSC062G07]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
122-240 1.66e-21

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


:

Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 86.51  E-value: 1.66e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 122 DPSDLAGTRASVERHLSRVGMDSDCLFDLMLTVGEAIGNAIDHAAGECA----LVVLACYEDRVVIDVTDCGCGFELRag 197
Cdd:COG2172     7 DLEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGGDPdgpvEVELELDPDGLEIEVRDEGPGFDPE-- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1092709503 198 EAVPRVDETSERGRGIRLMRLLADSVTIGRKPwgKGTLVRIVK 240
Cdd:COG2172    85 DLPDPYSTLAEGGRGLFLIRRLMDEVEYESDP--GGTTVRLVK 125
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 2-95 2.42e-18

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


:

Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 77.18  E-value: 2.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   2 DTHPNIAVVHVGGDLDVTTVPRTRRLVEGLIDDGCRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANECVM 81
Cdd:cd07043     4 EERGGVLVVRLSGELDAATAPELREALEELLAEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSPAVR 83

                          90
                  ....*....|....
gi 1092709503  82 RTLRLSRLVDFAPV 95
Cdd:cd07043    84 RVLELTGLDRLFPI 97
 
Name Accession Description Interval E-value
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
122-240 1.66e-21

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 86.51  E-value: 1.66e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 122 DPSDLAGTRASVERHLSRVGMDSDCLFDLMLTVGEAIGNAIDHAAGECA----LVVLACYEDRVVIDVTDCGCGFELRag 197
Cdd:COG2172     7 DLEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGGDPdgpvEVELELDPDGLEIEVRDEGPGFDPE-- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1092709503 198 EAVPRVDETSERGRGIRLMRLLADSVTIGRKPwgKGTLVRIVK 240
Cdd:COG2172    85 DLPDPYSTLAEGGRGLFLIRRLMDEVEYESDP--GGTTVRLVK 125
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 2-95 2.42e-18

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 77.18  E-value: 2.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   2 DTHPNIAVVHVGGDLDVTTVPRTRRLVEGLIDDGCRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANECVM 81
Cdd:cd07043     4 EERGGVLVVRLSGELDAATAPELREALEELLAEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSPAVR 83

                          90
                  ....*....|....
gi 1092709503  82 RTLRLSRLVDFAPV 95
Cdd:cd07043    84 RVLELTGLDRLFPI 97
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
122-240 5.56e-16

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 71.94  E-value: 5.56e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 122 DPSDLAGTRASVERHLSRVGMDSDCLFDLMLTVGEAIGNAIDHAAGECA----LVVLACYEDRVVIDVTDCGCGF---EL 194
Cdd:pfam13581   4 DPEQLRAARRVLEAVLRRAGLPEELLDEVELAVGEACTNAVEHAYREGPegpvEVRLTSDGGGLVVTVADSGPPFdplTL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1092709503 195 RAGEAVPRVDETSERGRGIRLMRLLADSVTIGRKPwgKGTLVRIVK 240
Cdd:pfam13581  84 PPPDLEEPDEDRKEGGRGLALIRGLMDDVEYTRGG--EGNTVRMRK 127
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
 1-96 1.39e-15

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 70.33  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   1 MDTHPNIAVVHVGGDLDVTTVPRTRRLVEGLID-DGCRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANEC 79
Cdd:TIGR00377   7 TEVQEGVVVVRLSGELDAHTAPLLREKVTPAAErTGIRPIVLDLEDLEFMDSSGLGVLLGRYKQVRRVGGQLVLVSVSPR 86

                          90
                  ....*....|....*..
gi 1092709503  80 VMRTLRLSRLVDFAPVS 96
Cdd:TIGR00377  87 VARLLDITGLLRIIPIY 103
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 2-89 1.08e-14

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 67.57  E-value: 1.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   2 DTHPNIAVVHVGGDLDVTTVPRTRRLVEGLIDDGCRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANECVM 81
Cdd:COG1366     5 EVRDGVLVLPLIGELDAARAPELREALLEALETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPAVA 84


                  ....*...
gi 1092709503  82 RTLRLSRL 89
Cdd:COG1366    85 RVLELTGL 92
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 1-95 4.23e-12

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 60.71  E-value: 4.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   1 MDTHPNIAVVHVGGDLDVTTVPRTRRLVEGLIDDG-CRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANEC 79
Cdd:pfam01740   4 AEEIPGILILRLDGPLDFANAESLRERLLRALEEGeIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPE 83

                          90
                  ....*....|....*.
gi 1092709503  80 VMRTLRLSRLVDFAPV 95
Cdd:pfam01740  84 VARTLEKTGLDDIIKI 99
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 152-240 3.05e-11

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 58.05  E-value: 3.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 152 LTVGEAIGNAIDHAAGECA----LVVLACYEDRVVIDVTDCGCGFELRAGeAVPRVDEtSERGRGIRLMRLLADSVTIGR 227
Cdd:cd16936     3 LAVSEAVTNAVRHAYRHDGpgpvRLELDLDPDRLRVEVTDSGPGFDPLRP-ADPDAGL-REGGRGLALIRALMDEVGYRR 80

                          90
                  ....*....|...
gi 1092709503 228 KPWGKgtLVRIVK 240
Cdd:cd16936    81 TPGGK--TVWLEL 91
PRK04069 PRK04069
serine-protein kinase RsbW; Provisional
 138-243 7.15e-08

serine-protein kinase RsbW; Provisional


Pssm-ID: 235217 [Multi-domain]  Cd Length: 161  Bit Score: 50.69  E-value: 7.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 138 SRVGMDSDCLFDLMLTVGEAIGNAIDHA--AGECALVVLAC--YEDRVVIDVTDCGCGF--ELRAGEAVP-----RVDET 206
Cdd:PRK04069   31 NRMGFSYDDIEDMKIAVSEACTNAVQHAykEDEVGEIHIRFeiYEDRLEIVVADNGVSFdyETLKSKLGPydiskPIEDL 110

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1092709503 207 SERGRGIRLMRLLADSVTIGRKpwgKGTLVRIVKLRR 243
Cdd:PRK04069  111 REGGLGLFLIETLMDDVTVYKD---SGVTVSMTKYIN 144
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 150-238 3.69e-05

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 41.87  E-value: 3.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503  150 LMLTVGEAIGNAIDHAAGECALVV-LACYEDRVVIDVTDCGCGFELRAGEAV--------PRVDETSERGRGIRLMRLLA 220
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGRITVtLERDGDHVEITVEDNGPGIPPEDLEKIfepffrtdKRSRKIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|..
gi 1092709503  221 D----SVTIGRKPwGKGTLVRI 238
Cdd:smart00387  86 ElhggEISVESEP-GGGTTFTI 106
 
Name Accession Description Interval E-value
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
122-240 1.66e-21

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 86.51  E-value: 1.66e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 122 DPSDLAGTRASVERHLSRVGMDSDCLFDLMLTVGEAIGNAIDHAAGECA----LVVLACYEDRVVIDVTDCGCGFELRag 197
Cdd:COG2172     7 DLEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGGDPdgpvEVELELDPDGLEIEVRDEGPGFDPE-- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1092709503 198 EAVPRVDETSERGRGIRLMRLLADSVTIGRKPwgKGTLVRIVK 240
Cdd:COG2172    85 DLPDPYSTLAEGGRGLFLIRRLMDEVEYESDP--GGTTVRLVK 125
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 2-95 2.42e-18

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 77.18  E-value: 2.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   2 DTHPNIAVVHVGGDLDVTTVPRTRRLVEGLIDDGCRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANECVM 81
Cdd:cd07043     4 EERGGVLVVRLSGELDAATAPELREALEELLAEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSPAVR 83

                          90
                  ....*....|....
gi 1092709503  82 RTLRLSRLVDFAPV 95
Cdd:cd07043    84 RVLELTGLDRLFPI 97
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
122-240 5.56e-16

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 71.94  E-value: 5.56e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 122 DPSDLAGTRASVERHLSRVGMDSDCLFDLMLTVGEAIGNAIDHAAGECA----LVVLACYEDRVVIDVTDCGCGF---EL 194
Cdd:pfam13581   4 DPEQLRAARRVLEAVLRRAGLPEELLDEVELAVGEACTNAVEHAYREGPegpvEVRLTSDGGGLVVTVADSGPPFdplTL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1092709503 195 RAGEAVPRVDETSERGRGIRLMRLLADSVTIGRKPwgKGTLVRIVK 240
Cdd:pfam13581  84 PPPDLEEPDEDRKEGGRGLALIRGLMDDVEYTRGG--EGNTVRMRK 127
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
 1-96 1.39e-15

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 70.33  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   1 MDTHPNIAVVHVGGDLDVTTVPRTRRLVEGLID-DGCRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANEC 79
Cdd:TIGR00377   7 TEVQEGVVVVRLSGELDAHTAPLLREKVTPAAErTGIRPIVLDLEDLEFMDSSGLGVLLGRYKQVRRVGGQLVLVSVSPR 86

                          90
                  ....*....|....*..
gi 1092709503  80 VMRTLRLSRLVDFAPVS 96
Cdd:TIGR00377  87 VARLLDITGLLRIIPIY 103
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 2-89 1.08e-14

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 67.57  E-value: 1.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   2 DTHPNIAVVHVGGDLDVTTVPRTRRLVEGLIDDGCRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANECVM 81
Cdd:COG1366     5 EVRDGVLVLPLIGELDAARAPELREALLEALETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPAVA 84


                  ....*...
gi 1092709503  82 RTLRLSRL 89
Cdd:COG1366    85 RVLELTGL 92
SpoIIAA COG5815
Stage II sporulation protein SpoIIAA (antagonist of anti-sigma F factor) [Cell cycle control, ...
 6-87 8.65e-13

Stage II sporulation protein SpoIIAA (antagonist of anti-sigma F factor) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444517  Cd Length: 110  Bit Score: 62.84  E-value: 8.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   6 NIAVVHVGGDLDVTTVPRTRRLVEGLID-DGCRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANECVMRTL 84
Cdd:COG5815    10 DTLIVRLEGELDHHTAEELREKIDRAIEkGGVKHLILNLEGVSFMDSSGLGVILGRYKKIKALGGKVAVINVSPQVKRIF 89


                  ...
gi 1092709503  85 RLS 87
Cdd:COG5815    90 ELS 92
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 1-95 4.23e-12

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 60.71  E-value: 4.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   1 MDTHPNIAVVHVGGDLDVTTVPRTRRLVEGLIDDG-CRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANEC 79
Cdd:pfam01740   4 AEEIPGILILRLDGPLDFANAESLRERLLRALEEGeIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPE 83

                          90
                  ....*....|....*.
gi 1092709503  80 VMRTLRLSRLVDFAPV 95
Cdd:pfam01740  84 VARTLEKTGLDDIIKI 99
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 152-240 3.05e-11

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 58.05  E-value: 3.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 152 LTVGEAIGNAIDHAAGECA----LVVLACYEDRVVIDVTDCGCGFELRAGeAVPRVDEtSERGRGIRLMRLLADSVTIGR 227
Cdd:cd16936     3 LAVSEAVTNAVRHAYRHDGpgpvRLELDLDPDRLRVEVTDSGPGFDPLRP-ADPDAGL-REGGRGLALIRALMDEVGYRR 80

                          90
                  ....*....|...
gi 1092709503 228 KPWGKgtLVRIVK 240
Cdd:cd16936    81 TPGGK--TVWLEL 91
PRK04069 PRK04069
serine-protein kinase RsbW; Provisional
 138-243 7.15e-08

serine-protein kinase RsbW; Provisional


Pssm-ID: 235217 [Multi-domain]  Cd Length: 161  Bit Score: 50.69  E-value: 7.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 138 SRVGMDSDCLFDLMLTVGEAIGNAIDHA--AGECALVVLAC--YEDRVVIDVTDCGCGF--ELRAGEAVP-----RVDET 206
Cdd:PRK04069   31 NRMGFSYDDIEDMKIAVSEACTNAVQHAykEDEVGEIHIRFeiYEDRLEIVVADNGVSFdyETLKSKLGPydiskPIEDL 110

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1092709503 207 SERGRGIRLMRLLADSVTIGRKpwgKGTLVRIVKLRR 243
Cdd:PRK04069  111 REGGLGLFLIETLMDDVTVYKD---SGVTVSMTKYIN 144
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 154-238 6.38e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 46.01  E-value: 6.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 154 VGEAIGNAIDHAAGECALVVLACYEDRVVIDVTDCGCGFELRAGEAvprvdetsERGRGIRLMR----LLADSVTIGRKP 229
Cdd:cd16917     5 VQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPG--------GGGFGLLGMReraeLLGGTLTIGSRP 76


                  ....*....
gi 1092709503 230 wGKGTLVRI 238
Cdd:cd16917    77 -GGGTRVTA 84
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 149-238 6.71e-07

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 46.59  E-value: 6.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 149 DLMLTVGEAIGNAIDHAAGECALVVLACYEDRVVIDVTDCGCGFEL----RAGEAVPRVDETSERGRGI------RLMRL 218
Cdd:pfam02518   5 RLRQVLSNLLDNALKHAAKAGEITVTLSEGGELTLTVEDNGIGIPPedlpRIFEPFSTADKRGGGGTGLglsivrKLVEL 84

                          90       100
                  ....*....|....*....|
gi 1092709503 219 LADSVTIGRKPwGKGTLVRI 238
Cdd:pfam02518  85 LGGTITVESEP-GGGTTVTL 103
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
 2-91 7.84e-07

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 46.47  E-value: 7.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   2 DTHPNIAVVHVGGDLDVTTVPRTRRLVEGLIDDG--CRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANEC 79
Cdd:cd07042     5 EEPPGVLIYRIDGPLFFGNAEYFKDRLLRLVDEDppLKVVILDLSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQ 84

                          90
                  ....*....|..
gi 1092709503  80 VMRTLRLSRLVD 91
Cdd:cd07042    85 VRELLERAGLLD 96
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
124-239 3.35e-06

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 46.92  E-value: 3.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 124 SDLAGTRASVERHLSRVGMDSDCLFDLMLTVGEAIGNAIDHAAGECALVVLACYEDRVVIDVTDCGCGFElrageavprV 203
Cdd:COG4585   137 LRAAGIRVELDVDGDPDRLPPEVELALYRIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGFD---------P 207

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1092709503 204 DETSERGRGIRLMR----LLADSVTIGRKPwGKGTLVRIV 239
Cdd:COG4585   208 EAAPGGGLGLRGMReraeALGGTLTIGSAP-GGGTRVRAT 246
MlaB COG3113
Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, ...
 8-94 5.46e-06

Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, contains STAS domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442347 [Multi-domain]  Cd Length: 97  Bit Score: 43.70  E-value: 5.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   8 AVVHVGGDLDVTTVPRTRRLVEGLIDDGcRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANECVMRTLRLS 87
Cdd:COG3113    12 GTLRLSGELTRDTVLALWAQLLALLAAG-GAVEIDLSGVTRVDSAGLALLLELLREARAQGKTLRLTGVPEQLRTLAALY 90


                  ....*..
gi 1092709503  88 RLVDFAP 94
Cdd:COG3113    91 GLDELLP 97
HATPase_SpoIIAB-like cd16942
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ...
 130-240 3.10e-05

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.


Pssm-ID: 340418 [Multi-domain]  Cd Length: 135  Bit Score: 42.53  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 130 RASVERHLSRVGMDSDCLFDLMLTVGEAIGNAIDHAAGECA---LVVLACYEDRVV-IDVTDCGCGFE--LRAGEAVPRV 203
Cdd:cd16942    19 RVTVAAFVAQLDPTIDELTEIKTVVSEAVTNAIIHGYNNDPngiVSISVIIEDGVVhLTVRDEGVGIPdiEEARQPLFTT 98

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1092709503 204 DETSER-GRGIRLMRLLADSVTIgRKPWGKGTLVRIVK 240
Cdd:cd16942    99 KPELERsGMGFTIMENFMDEVIV-ESEVNKGTTVYLKK 135
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 150-238 3.69e-05

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 41.87  E-value: 3.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503  150 LMLTVGEAIGNAIDHAAGECALVV-LACYEDRVVIDVTDCGCGFELRAGEAV--------PRVDETSERGRGIRLMRLLA 220
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGRITVtLERDGDHVEITVEDNGPGIPPEDLEKIfepffrtdKRSRKIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|..
gi 1092709503  221 D----SVTIGRKPwGKGTLVRI 238
Cdd:smart00387  86 ElhggEISVESEP-GGGTTFTI 106
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
 2-91 4.77e-05

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 43.94  E-value: 4.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   2 DTHPNIAVVHVGGDLDVTTVPRTRRLVEGLIDDGcRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANECVM 81
Cdd:COG0659   418 ETGPGVLVYRLDGPLFFGNAERLKERLDALAPDP-RVVILDLSAVPFIDATALEALEELAERLRARGITLELAGLKPPVR 496

                          90
                  ....*....|
gi 1092709503  82 RTLRLSRLVD 91
Cdd:COG0659   497 DLLERAGLLD 506
STAS_2 pfam13466
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 10-89 1.59e-04

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 433231 [Multi-domain]  Cd Length: 80  Bit Score: 39.13  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503  10 VHVGGDLDVTTVPRTRRLVEGLIDDGcRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANECVMRTLRLSRL 89
Cdd:pfam13466   1 LSLSGELDADTAPALREALLAALAAG-SPVVVDLSGVERVDSAGLALLLALARRARARGKRLVLRGLPPALLRLLRLLGL 79
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
160-239 8.92e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 40.00  E-value: 8.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 160 NAIDHA----AGECALVVLACYE-DRVVIDVTDCGCGFELRAGEAVPRVDETSERGRGI-------RLmRLL---ADSVT 224
Cdd:COG2972   347 NAIEHGiepkEGGGTIRISIRKEgDRLVITVEDNGVGMPEEKLEKLLEELSSKGEGRGIglrnvreRL-KLYygeEYGLE 425

                          90
                  ....*....|....*
gi 1092709503 225 IGRKPwGKGTLVRIV 239
Cdd:COG2972   426 IESEP-GEGTTVTIR 439
STAS cd06844
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of ...
 1-89 1.81e-03

Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain is found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors, like anti-anti-sigma factors and "stressosome" components. The sigma factor regulators are involved in protein-protein interaction which is regulated by phosphorylation.


Pssm-ID: 132911 [Multi-domain]  Cd Length: 100  Bit Score: 36.69  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503   1 MDTHPNIAVVHVGGDLDVTTVPRTR-RLVEGLIDDGCRRIILNMAAATAIDSTGLGFVLGEIRRMRSVGGLLSITEANEC 79
Cdd:cd06844     3 LEKVDDYWVVRLEGELDHHSVEQFKeELLHNITNVAGKTIVIDISALEFMDSSGTGVLLERSRLAEAVGGQFVLTGISPA 82

                          90
                  ....*....|
gi 1092709503  80 VMRTLRLSRL 89
Cdd:cd06844    83 VRITLTESGL 92
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 126-239 4.39e-03

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 37.96  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092709503 126 LAGTRASVERHLSRVGMDSDCLFDLMLTVGEAIGNAIDHAAGECA----LVVLACYEDRVVIDVTDCGCGFElrageavP 201
Cdd:COG3920   376 YGGRGIRIELDGPDVELPADAAVPLGLILNELVTNALKHAFLSGEggriRVSWRREDGRLRLTVSDNGVGLP-------E 448

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1092709503 202 RVDETSERGRGIRLMRLLAD----SVTIGRkpwGKGTLVRIV 239
Cdd:COG3920   449 DVDPPARKGLGLRLIRALVRqlggTLELDR---PEGTRVRIT 487
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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