LTA synthase family protein [Pseudomonas sp. HMSC16B01]
Protein Classification
LTA synthase family protein( domain architecture ID 11443228)
LTA (lipoteichoic acid) synthase family protein belonging to the alkaline phosphatase (AlkP) superfamily; similar to LTA synthase which catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, an important cell wall polymer
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||||
| MdoB | COG1368 | Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
56-525 | 1.63e-56 | ||||||||
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis]; : Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 203.35 E-value: 1.63e-56
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| Name | Accession | Description | Interval | E-value | ||||||||
| MdoB | COG1368 | Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
56-525 | 1.63e-56 | ||||||||
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 203.35 E-value: 1.63e-56
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| Sulfatase | pfam00884 | Sulfatase; |
223-501 | 1.86e-45 | ||||||||
Sulfatase; Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 164.90 E-value: 1.86e-45
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| LTA_synthase | cd16015 | Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
223-500 | 1.03e-44 | ||||||||
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain. Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 162.08 E-value: 1.03e-44
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| PRK12363 | PRK12363 | phosphoglycerol transferase I; Provisional |
277-451 | 4.58e-12 | ||||||||
phosphoglycerol transferase I; Provisional Pssm-ID: 171438 Cd Length: 703 Bit Score: 69.55 E-value: 4.58e-12
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| Name | Accession | Description | Interval | E-value | ||||||||
| MdoB | COG1368 | Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
56-525 | 1.63e-56 | ||||||||
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 203.35 E-value: 1.63e-56
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| Sulfatase | pfam00884 | Sulfatase; |
223-501 | 1.86e-45 | ||||||||
Sulfatase; Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 164.90 E-value: 1.86e-45
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| LTA_synthase | cd16015 | Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
223-500 | 1.03e-44 | ||||||||
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain. Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 162.08 E-value: 1.03e-44
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| sulfatase_like | cd16148 | uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
249-513 | 3.91e-19 | ||||||||
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 87.99 E-value: 3.91e-19
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| sulfatase_like | cd16037 | uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
349-536 | 1.16e-16 | ||||||||
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 81.82 E-value: 1.16e-16
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| AslA | COG3119 | Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
365-534 | 2.11e-14 | ||||||||
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 75.69 E-value: 2.11e-14
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| SGSH | cd16027 | N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
272-526 | 2.51e-13 | ||||||||
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities. Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 72.16 E-value: 2.51e-13
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| PRK12363 | PRK12363 | phosphoglycerol transferase I; Provisional |
277-451 | 4.58e-12 | ||||||||
phosphoglycerol transferase I; Provisional Pssm-ID: 171438 Cd Length: 703 Bit Score: 69.55 E-value: 4.58e-12
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| sulfatase_like | cd16022 | sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
384-511 | 3.36e-09 | ||||||||
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 57.83 E-value: 3.36e-09
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| G6S | cd16147 | glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
376-511 | 6.59e-09 | ||||||||
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 58.72 E-value: 6.59e-09
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| PRK03776 | PRK03776 | phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase; |
312-451 | 7.06e-09 | ||||||||
phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase; Pssm-ID: 179648 Cd Length: 762 Bit Score: 59.34 E-value: 7.06e-09
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| sulfatase_like | cd16034 | uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
311-512 | 1.08e-08 | ||||||||
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 57.96 E-value: 1.08e-08
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| choline-sulfatase | cd16032 | choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
387-455 | 3.53e-08 | ||||||||
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon. Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 56.05 E-value: 3.53e-08
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| sulfatase_like | cd16033 | uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
374-512 | 6.73e-08 | ||||||||
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 55.69 E-value: 6.73e-08
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| ARS_like | cd16143 | uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
282-451 | 3.12e-07 | ||||||||
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 53.36 E-value: 3.12e-07
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| ARS_like | cd16144 | uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
343-451 | 3.47e-07 | ||||||||
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 53.32 E-value: 3.47e-07
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| ALP_like | cd00016 | alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
375-455 | 3.77e-06 | ||||||||
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases. Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 48.96 E-value: 3.77e-06
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| sulfatase_like | cd16155 | uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
372-512 | 5.15e-06 | ||||||||
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 49.49 E-value: 5.15e-06
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| PMH | cd16028 | Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
421-512 | 1.08e-05 | ||||||||
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile. Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 48.79 E-value: 1.08e-05
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| ARS_like | cd16146 | uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
372-451 | 1.59e-05 | ||||||||
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 47.93 E-value: 1.59e-05
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| ARS_like | cd16142 | uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
337-451 | 4.53e-05 | ||||||||
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 46.37 E-value: 4.53e-05
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| sulfatase_like | cd16149 | uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
376-455 | 4.89e-05 | ||||||||
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 45.69 E-value: 4.89e-05
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| ARSG | cd16161 | arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
313-451 | 5.50e-05 | ||||||||
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder. Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 46.31 E-value: 5.50e-05
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| 4-S | cd16029 | N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
280-451 | 7.98e-05 | ||||||||
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme. Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 45.62 E-value: 7.98e-05
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| sulfatase_like | cd16153 | uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
386-513 | 4.80e-04 | ||||||||
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 42.75 E-value: 4.80e-04
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| GALNS_like | cd16026 | galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
384-451 | 7.27e-04 | ||||||||
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A. Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 42.55 E-value: 7.27e-04
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| sulfatase_like | cd16035 | uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
297-455 | 1.12e-03 | ||||||||
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 41.81 E-value: 1.12e-03
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| AtaC | COG1524 | c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
419-455 | 3.73e-03 | ||||||||
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms]; Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 40.50 E-value: 3.73e-03
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| ARS_like | cd16145 | uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
372-451 | 4.23e-03 | ||||||||
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 40.27 E-value: 4.23e-03
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| AP-SPAP | cd16016 | SPAP is a subclass of alkaline phosphatase (AP); Alkaline phosphatases are non-specific ... |
394-459 | 5.38e-03 | ||||||||
SPAP is a subclass of alkaline phosphatase (AP); Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Although SPAP is a subclass of alkaline phosphatase, SPAP has many differences from other APs: 1) the catalytic residue is a threonine instead of serine, 2) there is no binding pocket for the third metal ion, and 3) the arginine residue forming bidentate hydrogen bonding is deleted in SPAP. A lysine and an asparagine residue, recruited together for the first time into the active site, bind the substrate phosphoryl group in a manner not observed before in any other AP. Pssm-ID: 293740 [Multi-domain] Cd Length: 457 Bit Score: 39.82 E-value: 5.38e-03
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