|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
436-1116 |
0e+00 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 569.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 436 EPPVLRLRADFRPGHELVLRWSWLYFDPPRELGLDAGGDPLRDTRHEDAVLRAVAELWPRAGRAEEQVLEGVGAARFSEQ 515
Cdd:COG0553 1 LLLLLLLLALGALGLLLTELLLLLRLGALLLELVLARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 516 VLPLLQRADHVRVDVTGDRPDYRELKAAPRIEVGTKATQNDWFDLGVQVSVDGHVLPFVELFTALVQGRTTLILADGSYL 595
Cdd:COG0553 81 ALLLLRLLLALLLLALLLLLAGLLALALLLLALLGLLLSLALLLLLLLLLLLLLLALLLVLLAALLLLLLLLLLLALLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 596 GLDHPAFDRLRALLSEAATLQEWTPEHTPVSRHQVGFWEDLKELADEVDEDPEWTAAVGRLAAVERLPEAPR--PAGLKA 673
Cdd:COG0553 161 RLLLLALLLLALEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAFRLRRLREALEslPAGLKA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 674 DLRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPpFLVVAPSSVVSVWAAEAEKFTPDLDVR 753
Cdd:COG0553 241 TLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARP-VLIVAPTSLVGNWQRELAKFAPGLRVL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 754 VLD-TTTRKRGtavADEVAGADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGTP 832
Cdd:COG0553 320 VLDgTRERAKG---ANPFEDADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTP 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 833 MENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGgDPERMAALRRRVRPFMLRRSKELVAKDLPSKQEQILQVELEP 912
Cdd:COG0553 397 VENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKG-DEEALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTP 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 913 AHRKLYDRVLQRERRKVLGLLGDmdGNRFTIFTSLTLLRMLALAPQIVDD--QYASVPSSKLERFLDDLTEVIGEGHRVI 990
Cdd:COG0553 476 EQRALYEAVLEYLRRELEGAEGI--RRRGLILAALTRLRQICSHPALLLEegAELSGRSAKLEALLELLEELLAEGEKVL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 991 VFSQFTSFLRVIAEELDHLEIEHAYLDGST--RGRADVIRGFREG-EAPVFLISLKAGGFGLTLTEADYVFLMDPWWNPA 1067
Cdd:COG0553 554 VFSQFTDTLDLLEERLEERGIEYAYLHGGTsaEERDELVDRFQEGpEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPA 633
|
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 1072319335 1068 AEAQAVDRAHRIGQERTVMVYRLVSEGTIEEKVLELQRRKAELFGALMD 1116
Cdd:COG0553 634 VEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
671-891 |
1.90e-90 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 289.47 E-value: 1.90e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 671 LKADLRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPpFLVVAPSSVVSVWAAEAEKFTPDL 750
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGP-SLVVAPTSLIYNWEEEAAKFAPEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 751 DVRVLDTTTRKRGtaVADEVAGADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAITG 830
Cdd:cd18012 80 KVLVIHGTKRKRE--KLRALEDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTG 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072319335 831 TPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGGDPERMAALRRRVRPFMLRRSK 891
Cdd:cd18012 158 TPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGDEEALEELKKLISPFILRRLK 218
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
626-1110 |
1.88e-68 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 250.10 E-value: 1.88e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 626 SRHQVGFWEDL--KELADEVDEDPEWTAAVgRLAAverlpeapRPAGLKADLRPYQEEGLRWLAFLWEQDLGGILADDMG 703
Cdd:PLN03142 128 GRHASKLTEEEedEEYLKEEEDGLGGSGGT-RLLV--------QPSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMG 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 704 LGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRVLDTTTRKRgTAVADE--VAGA-DVVVTSY 780
Cdd:PLN03142 199 LGKTLQTISLLGYLHEYRGITGPHMVVAPKSTLGNWMNEIRRFCPVLRAVKFHGNPEER-AHQREEllVAGKfDVCVTSF 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 781 TLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRE 860
Cdd:PLN03142 278 EMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDE 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 861 TYVTPIEtGGDPERMAALRRRVRPFMLRRSKELVAKDLPSKQEQILQVELEPAHRKLYDRVLQRERRKVlgllgDMDGNR 940
Cdd:PLN03142 358 WFQISGE-NDQQEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLDVV-----NAGGER 431
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 941 FTIFTSLTLLRMLALAPQIVDDQYASVP----------SSK---LERFLDDLTEvigEGHRVIVFSQFTSFLRVIAEELD 1007
Cdd:PLN03142 432 KRLLNIAMQLRKCCNHPYLFQGAEPGPPyttgehlvenSGKmvlLDKLLPKLKE---RDSRVLIFSQMTRLLDILEDYLM 508
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 1008 HLEIEHAYLDGSTRG--RADVIRGF-REG-EAPVFLISLKAGGFGLTLTEADYVFLMDPWWNPAAEAQAVDRAHRIGQER 1083
Cdd:PLN03142 509 YRGYQYCRIDGNTGGedRDASIDAFnKPGsEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKK 588
|
490 500
....*....|....*....|....*..
gi 1072319335 1084 TVMVYRLVSEGTIEEKVLELQRRKAEL 1110
Cdd:PLN03142 589 EVQVFRFCTEYTIEEKVIERAYKKLAL 615
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
678-951 |
2.20e-59 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 206.00 E-value: 2.20e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 678 YQEEGLRWLAFLWEQD-LGGILADDMGLGKTVQTLALFAHARQARPER-PPFLVVAPSSVVSVWAAEAEKFT--PDLDVR 753
Cdd:pfam00176 1 YQIEGVNWMLSLENNLgRGGILADEMGLGKTLQTISLLLYLKHVDKNWgGPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 754 VLDTTTRKRGTAVADE--VAGADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGT 831
Cdd:pfam00176 81 VLHGNKRPQERWKNDPnfLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 832 PMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGGDPERMAALRRRVRPFMLRRSKELVAKDLPSKQEQILQVELE 911
Cdd:pfam00176 161 PLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCRLS 240
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1072319335 912 PAHRKLYDRVLQRERRKVLGLLGDMDGNRFTIFTSLTLLR 951
Cdd:pfam00176 241 KLQRKLYQTFLLKKDLNAIKTGEGGREIKASLLNILMRLR 280
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
675-849 |
2.80e-56 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 192.78 E-value: 2.80e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAVADEVAG-ADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGTPM 833
Cdd:cd17919 81 YHGSQRERAQIRAKEKLDkFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPL 160
|
170
....*....|....*.
gi 1072319335 834 ENSLSDLWALLGVVVP 849
Cdd:cd17919 161 QNNLEELWALLDFLDP 176
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
969-1091 |
6.32e-53 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 181.14 E-value: 6.32e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 969 SSKLERFLDDLTEVIGEGHRVIVFSQFTSFLRVIAEELDHLEIEHAYLDGSTRG--RADVIRGFREGEAP-VFLISLKAG 1045
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSkeRQKLVDRFNEDPDIrVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1072319335 1046 GFGLTLTEADYVFLMDPWWNPAAEAQAVDRAHRIGQERTVMVYRLV 1091
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
675-889 |
2.04e-50 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 177.93 E-value: 2.04e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERP-----PFLVVAPSSVVSVWAAEAEKFTPD 749
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILASDHHKRANSFnsenlPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 750 LDVRVLD----TTTRKRgtaVADEVAGADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFR 825
Cdd:cd17999 81 AFLKPLAyvgpPQERRR---LREQGEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHR 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1072319335 826 LAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGGDPE-----------RMAALRRRVRPFMLRR 889
Cdd:cd17999 158 LILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKasakeqeagalALEALHKQVLPFLLRR 232
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
675-891 |
3.56e-46 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 165.57 E-value: 3.56e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:cd17997 4 MRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLRVVV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAVADEVAGA--DVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGTP 832
Cdd:cd17997 84 LIGDKEERADIIRDVLLPGkfDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTP 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1072319335 833 MENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGGDPERMAALRRRVRPFMLRRSK 891
Cdd:cd17997 164 LQNNLHELWALLNFLLPDVFTSSEDFDEWFNVNNCDDDNQEVVQRLHKVLRPFLLRRIK 222
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
675-889 |
7.16e-43 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 156.77 E-value: 7.16e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQ----------ARPER----------PPFLVVAPSS 734
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVLGktgtrrdrenNRPRFkkkppassakKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 735 VVSVWAAEAEK---FTpdldVRVLDTTTRKRGTAVADEVAGADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAA 811
Cdd:cd18005 81 VLYNWKDELDTwghFE----VGVYHGSRKDDELEGRLKAGRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 812 KVHTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETG------------GDpERMAALR 879
Cdd:cd18005 157 KLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGqrhtatarelrlGR-KRKQELA 235
|
250
....*....|
gi 1072319335 880 RRVRPFMLRR 889
Cdd:cd18005 236 VKLSKFFLRR 245
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
675-889 |
6.45e-42 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 153.17 E-value: 6.45e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTpDLDVRV 754
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGPFLVIAPLSTIPNWQREFETWT-DMNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 L-DTTTRKR------------GTAVADEVAGADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLR 821
Cdd:cd17995 80 YhGSGESRQiiqqyemyfkdaQGRKKKGVYKFDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLT 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072319335 822 APFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYvtpietgGD---PERMAALRRRVRPFMLRR 889
Cdd:cd17995 160 LEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF-------GDlktAEQVEKLQALLKPYMLRR 223
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
675-889 |
2.21e-41 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 151.89 E-value: 2.21e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGT--------AVADEVAGADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRL 826
Cdd:cd18002 81 YWGNPKDRKVlrkfwdrkNLYTRDAPFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1072319335 827 AITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIE------TGGDPERMAALRRRVRPFMLRR 889
Cdd:cd18002 161 LLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIEshaenkTGLNEHQLKRLHMILKPFMLRR 229
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
674-891 |
9.53e-41 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 150.21 E-value: 9.53e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 674 DLRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVR 753
Cdd:cd17996 3 TLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSKI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 754 VLDTTTRKRGTAVADEVAGA-DVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKV-HTVARDLRAPFRLAITGT 831
Cdd:cd17996 83 VYKGTPDVRKKLQSQIRAGKfNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLtQTLNTYYHARYRLLLTGT 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072319335 832 PMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGG--------DPERMAALRRR---VRPFMLRRSK 891
Cdd:cd17996 163 PLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTGeqvkielnEEETLLIIRRLhkvLRPFLLRRLK 233
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
675-891 |
4.70e-40 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 148.30 E-value: 4.70e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQaRPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:cd18009 4 MRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRE-RGVWGPFLVIAPLSTLPNWVNEFARFTPSVPVLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAV----ADEVAGAD--VVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAI 828
Cdd:cd18009 83 YHGTKEERERLRkkimKREGTLQDfpVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLL 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1072319335 829 TGTPMENSLSDLWALLGVVVPGLFPSHRRF-----------RETYVTPIETGGDPERMAALRRRVRPFMLRRSK 891
Cdd:cd18009 163 TGTPLQNNLSELWSLLNFLLPDVFDDLSSFeswfdfsslsdNAADISNLSEEREQNIVHMLHAILKPFLLRRLK 236
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
675-889 |
1.58e-39 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 146.34 E-value: 1.58e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKR-----GTAVADEVagaDVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAIT 829
Cdd:cd18003 81 YYGSAKERklkrqGWMKPNSF---HVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLT 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1072319335 830 GTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIE---TGGDPERMAALRR--RV-RPFMLRR 889
Cdd:cd18003 158 GTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPLTamsEGSQEENEELVRRlhKVlRPFLLRR 223
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
675-889 |
6.01e-39 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 144.42 E-value: 6.01e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:cd17993 2 LRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVIV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAVADEVAGA-------DVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLA 827
Cdd:cd17993 82 YLGDIKSRDTIREYEFYFSqtkklkfNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRLL 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1072319335 828 ITGTPMENSLSDLWALLGVVVPGLFPSHRRFREtyvtpiETGGDPER-MAALRRRVRPFMLRR 889
Cdd:cd17993 162 ITGTPLQNSLKELWALLHFLMPGKFDIWEEFEE------EHDEEQEKgIADLHKELEPFILRR 218
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
675-889 |
7.58e-39 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 144.12 E-value: 7.58e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAVAD--EVAGADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGTP 832
Cdd:cd18006 81 YMGDKEKRLDLQQDikSTNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTP 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1072319335 833 MENSLSDLWALLGVVVPGLFPSHR--RFRETYVtpiETGGDPERMAALRRRVRPFMLRR 889
Cdd:cd18006 161 IQNSLQELYALLSFIEPNVFPKDKldDFIKAYS---ETDDESETVEELHLLLQPFLLRR 216
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
675-889 |
8.25e-39 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 145.12 E-value: 8.25e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLweqdlGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSV---------------- 738
Cdd:cd18008 1 LLPYQKQGLAWMLPR-----GGILADEMGLGKTIQALALILATRPQDPKIPEELEENSSDPKKLylskttlivvplslls 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 739 -WAAEAEKFT--PDLDVRVLDTTTRKRgtaVADEVAGADVVVTSYTLLRIDAGQYGGLD----------------WGGVV 799
Cdd:cd18008 76 qWKDEIEKHTkpGSLKVYVYHGSKRIK---SIEELSDYDIVITTYGTLASEFPKNKKGGgrdskekeasplhrirWYRVI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 800 FDEAQFLKNRAAKVHTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFReTYVTPIETGGDPERMAALR 879
Cdd:cd18008 153 LDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFN-SDISKPFSKNDRKALERLQ 231
|
250
....*....|
gi 1072319335 880 RRVRPFMLRR 889
Cdd:cd18008 232 ALLKPILLRR 241
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
675-902 |
7.10e-38 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 142.50 E-value: 7.10e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:cd18064 16 LRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRAVC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAVADEVAGA--DVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGTP 832
Cdd:cd18064 96 LIGDKDQRAAFVRDVLLPGewDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTP 175
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 833 MENSLSDLWALLGVVVPGLFPSHRRFrETYVTPIETGGDPERMAALRRRVRPFMLRRSKELVAKDLPSKQ 902
Cdd:cd18064 176 LQNNLHELWALLNFLLPDVFNSAEDF-DSWFDTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKK 244
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
655-889 |
4.64e-35 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 133.98 E-value: 4.64e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 655 RLAAVERLPEAPRPAGLkaDLRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSS 734
Cdd:cd18054 3 RFVALKKQPSYIGGENL--ELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLLVVPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 735 VVSVWAAEAEKFTPDLDVRVLDTTTRKRGTAVADEVAGA-------DVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLK 807
Cdd:cd18054 81 TLTSWQREFEIWAPEINVVVYIGDLMSRNTIREYEWIHSqtkrlkfNALITTYEILLKDKTVLGSINWAFLGVDEAHRLK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 808 NRAAKVHTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGgdperMAALRRRVRPFML 887
Cdd:cd18054 161 NDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENG-----YQSLHKVLEPFLL 235
|
..
gi 1072319335 888 RR 889
Cdd:cd18054 236 RR 237
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
675-891 |
3.08e-34 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 131.68 E-value: 3.08e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:cd18065 16 LRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRAVC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAVADEVAGA--DVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGTP 832
Cdd:cd18065 96 LIGDKDARAAFIRDVMMPGewDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTP 175
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1072319335 833 MENSLSDLWALLGVVVPGLFPSHRRFrETYVTPIETGGDPERMAALRRRVRPFMLRRSK 891
Cdd:cd18065 176 LQNNLHELWALLNFLLPDVFNSADDF-DSWFDTKNCLGDQKLVERLHAVLKPFLLRRIK 233
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
675-889 |
1.56e-33 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 129.41 E-value: 1.56e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFA------HARQArperppfLVVAPSSVVSVWAAEAEKFTP 748
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSgmfdsgLIKSV-------LVVMPTSLIPHWVKEFAKWTP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 749 DLDVRVLDTTTRKRGTAVADEVA-GADVVVTSYTLLRIDAGQYGGLD-----WGGVVFDEAQFLKNRAAKVHTVARDLRA 822
Cdd:cd18001 74 GLRVKVFHGTSKKERERNLERIQrGGGVLLTTYGMVLSNTEQLSADDhdefkWDYVILDEGHKIKNSKTKSAKSLREIPA 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1072319335 823 PFRLAITGTPMENSLSDLWALLGVVVPG-LFPSHRRFRETYVTPIETGGDPE----------RMAA-LRRRVRPFMLRR 889
Cdd:cd18001 154 KNRIILTGTPIQNNLKELWALFDFACNGsLLGTRKTFKMEFENPITRGRDKDatqgekalgsEVAEnLRQIIKPYFLRR 232
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
675-889 |
2.18e-33 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 127.94 E-value: 2.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRv 754
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVV- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 ldtttrkrgTAVADEVagadvVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGTPME 834
Cdd:cd17994 80 ---------TYVGDHV-----LLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQ 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1072319335 835 NSLSDLWALLGVVVPGLFPSHRRFRETYvtpiETGGDPERMAALRRRVRPFMLRR 889
Cdd:cd17994 146 NNLEELFHLLNFLTPERFNNLQGFLEEF----ADISKEDQIKKLHDLLGPHMLRR 196
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
675-889 |
4.76e-33 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 128.17 E-value: 4.76e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRwlaFLWEQDLGG--------ILADDMGLGKTVQTLAL----FAHARQARPERPPFLVVAPSSVVSVWAAE 742
Cdd:cd18004 1 LRPHQREGVQ---FLYDCLTGRrgyggggaILADEMGLGKTLQAIALvwtlLKQGPYGKPTAKKALIVCPSSLVGNWKAE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 743 AEKFTPDLDVRVLdtttRKRGTAVADEVAGA--------DVVVTSYTLLRIDAGQYG-GLDWGGVVFDEAQFLKNRAAKV 813
Cdd:cd18004 78 FDKWLGLRRIKVV----TADGNAKDVKASLDffssastyPVLIISYETLRRHAEKLSkKISIDLLICDEGHRLKNSESKT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 814 HTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGGDP-----------ERMAALRRRV 882
Cdd:cd18004 154 TKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPdaseedkelgaERSQELSELT 233
|
....*..
gi 1072319335 883 RPFMLRR 889
Cdd:cd18004 234 SRFILRR 240
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
675-849 |
4.81e-31 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 120.89 E-value: 4.81e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTT-----------TRKRGTAVADEVAG-ADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRA 822
Cdd:cd18000 81 LHSSgsgtgseeklgSIERKSQLIRKVVGdGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRT 160
|
170 180
....*....|....*....|....*..
gi 1072319335 823 PFRLAITGTPMENSLSDLWALLGVVVP 849
Cdd:cd18000 161 PHRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
675-891 |
1.16e-30 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 121.69 E-value: 1.16e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPD-LDVR 753
Cdd:cd18062 24 LKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWVYEFDKWAPSvVKVS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 754 VLDTTTRKRGTAVADEVAGADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARD-LRAPFRLAITGTP 832
Cdd:cd18062 104 YKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQVLNThYVAPRRLLLTGTP 183
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1072319335 833 MENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGGDP------ERMAALRRR---VRPFMLRRSK 891
Cdd:cd18062 184 LQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKvdlneeETILIIRRLhkvLRPFLLRRLK 251
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
671-891 |
2.35e-30 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 120.94 E-value: 2.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 671 LKADLRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDL 750
Cdd:cd18063 20 INGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 751 DVRVLDTTTRKRGTAVADEVAGA-DVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARD-LRAPFRLAI 828
Cdd:cd18063 100 VKISYKGTPAMRRSLVPQLRSGKfNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNThYVAPRRILL 179
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1072319335 829 TGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGG------DPERMAALRRR---VRPFMLRRSK 891
Cdd:cd18063 180 TGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGervdlnEEETILIIRRLhkvLRPFLLRRLK 251
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
674-889 |
4.29e-30 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 119.77 E-value: 4.29e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 674 DLRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVR 753
Cdd:cd18053 20 ELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNAV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 754 VLDTTTRKRGTAVADEVAGA-------DVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRL 826
Cdd:cd18053 100 VYLGDINSRNMIRTHEWMHPqtkrlkfNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRL 179
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1072319335 827 AITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGgdperMAALRRRVRPFMLRR 889
Cdd:cd18053 180 LITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYG-----YASLHKELEPFLLRR 237
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
675-889 |
6.90e-30 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 119.01 E-value: 6.90e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAVADEVAGAD---------------------VVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKV 813
Cdd:cd18057 81 YTGDKESRSVIRENEFSFEDnairsgkkvfrmkkeaqikfhVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1072319335 814 HTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPietgGDPERMAALRRRVRPFMLRR 889
Cdd:cd18057 161 FRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADI----SKEDQIKKLHDLLGPHMLRR 232
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
675-852 |
1.42e-29 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 116.33 E-value: 1.42e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARpERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIG-IPGPHLVVVPSSTLDNWLREFKRWCPSLKVEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 ----LDTTTRKRGtAVADEVAGADVVVTSYTLL---RIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLA 827
Cdd:cd17998 80 yygsQEERKHLRY-DILKGLEDFDVIVTTYNLAtsnPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLL 158
|
170 180
....*....|....*....|....*
gi 1072319335 828 ITGTPMENSLSDLWALLGVVVPGLF 852
Cdd:cd17998 159 LTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
675-889 |
2.16e-28 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 114.78 E-value: 2.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDL---- 750
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMyvvt 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 751 -----DVRVL---------DTTTR--KRGTAVADEVA-GADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKV 813
Cdd:cd18056 81 yvgdkDSRAIirenefsfeDNAIRggKKASRMKKEASvKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1072319335 814 HTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETggdpERMAALRRRVRPFMLRR 889
Cdd:cd18056 161 FRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKE----DQIKKLHDMLGPHMLRR 232
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
675-889 |
1.83e-27 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 112.03 E-value: 1.83e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAVADEVAGAD---------------------VVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKV 813
Cdd:cd18055 81 YTGDKDSRAIIRENEFSFDDnavkggkkafkmkreaqvkfhVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1072319335 814 HTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPietgGDPERMAALRRRVRPFMLRR 889
Cdd:cd18055 161 FRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADI----SKEDQIKKLHDLLGPHMLRR 232
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
675-883 |
4.83e-26 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 108.15 E-value: 4.83e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRwlaFLWEQ----------DLGGILADDMGLGKTVQTLA-LFAHARQARPER------PPFLVVApssvvs 737
Cdd:cd18007 1 LKPHQVEGVR---FLWSNlvgtdvgsdeGGGCILAHTMGLGKTLQVITfLHTYLAAAPRRSrplvlcPASTLYN------ 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 738 vWAAEAEKFTPDLDVRVLDTTTRKR-GTAVADEVAGAD------VVVTSYTLLRIDAGQYGGLDWGG------------- 797
Cdd:cd18007 72 -WEDEFKKWLPPDLRPLLVLVSLSAsKRADARLRKINKwhkeggVLLIGYELFRNLASNATTDPRLKqefiaalldpgpd 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 798 -VVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGGDPERMA 876
Cdd:cd18007 151 lLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAGQCVDSTE 230
|
....*..
gi 1072319335 877 ALRRRVR 883
Cdd:cd18007 231 EDVRLML 237
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
675-888 |
5.57e-26 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 108.20 E-value: 5.57e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLafLWeqdLGGILADDMGLGKTVQTLAL-FAHARQARPERPPFLVVAPSSVVSV--------------- 738
Cdd:cd18070 1 LLPYQRRAVNWM--LV---PGGILADEMGLGKTVEVLALiLLHPRPDNDLDAADDDSDEMVCCPDclvaetpvsskatli 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 739 ---------WAAEAEKFTPDlDVRVLD-TTTRKRG---TAVADEVAGADVVVTSYTLLR-----IDAGQYGG-------- 792
Cdd:cd18070 76 vcpsailaqWLDEINRHVPS-SLKVLTyQGVKKDGalaSPAPEILAEYDIVVTTYDVLRtelhyAEANRSNRrrrrqkry 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 793 ---------LDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYv 863
Cdd:cd18070 155 eappsplvlVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFCDSDWWARVL- 233
|
250 260
....*....|....*....|....*
gi 1072319335 864 tpIETGGDPERMAALRRRVRPFMLR 888
Cdd:cd18070 234 --IRPQGRNKAREPLAALLKELLWR 256
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
675-889 |
1.18e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 106.28 E-value: 1.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLAlFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTpDLDVRV 754
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSIT-FLSEIFLMGIRGPFLIIAPLSTITNWEREFRTWT-EMNAIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAVADEVAGAD-------------VVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLR 821
Cdd:cd18058 79 YHGSQISRQMIQQYEMYYRDeqgnplsgifkfqVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKLMA 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072319335 822 APFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYvtpietgGD---PERMAALRRRVRPFMLRR 889
Cdd:cd18058 159 LEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEF-------GDlktEEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
675-889 |
3.77e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 105.14 E-value: 3.77e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPeRPPFLVVAPSSVVSVWAAEAEKFTpDLDVRV 754
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGI-HGPFLVIAPLSTITNWEREFNTWT-EMNTIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAVADE----------VAGA---DVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLR 821
Cdd:cd18060 79 YHGSLASRQMIQQYEmyckdsrgrlIPGAykfDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMD 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072319335 822 APFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYvtpietgGD---PERMAALRRRVRPFMLRR 889
Cdd:cd18060 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDF-------GDlktEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
675-889 |
8.09e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 103.96 E-value: 8.09e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLAlFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTpDLDVRV 754
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSIT-FLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAVADEVAGAD-------------VVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLR 821
Cdd:cd18059 79 YHGSQASRRTIQLYEMYFKDpqgrvikgsykfhAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMD 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072319335 822 APFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYvtpietgGD---PERMAALRRRVRPFMLRR 889
Cdd:cd18059 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEF-------GDlktEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
675-889 |
1.96e-24 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 102.67 E-value: 1.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRW-LAFlweqdlGG--ILADDMGLGKTVQTLALFAHARqarpERPPFLVVAPSSVVSVWAAEAEKFTPDL- 750
Cdd:cd18010 1 LLPFQREGVCFaLRR------GGrvLIADEMGLGKTVQAIAIAAYYR----EEWPLLIVCPSSLRLTWADEIERWLPSLp 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 751 --DVRVLDTTTRKRgtavadEVAGADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDL--RAPFRL 826
Cdd:cd18010 71 pdDIQVIVKSKDGL------RDGDAKVVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVI 144
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1072319335 827 AITGTPmenSLS---DLWALLGVVVPGLFPSHRRFRETYVTPIET--GGD-------PERMAALRRRVrpfMLRR 889
Cdd:cd18010 145 LLSGTP---ALSrpiELFTQLDALDPKLFGRFHDFGRRYCAAKQGgfGWDysgssnlEELHLLLLATI---MIRR 213
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
675-889 |
3.44e-23 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 99.85 E-value: 3.44e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAF---------LWEQD--------------------LGGILADDMGLGKTVQTLALFAHARQarperp 725
Cdd:cd18071 1 LLPHQKQALAWMVSrensqdlppFWEEAvglflntitnfsqkkrpelvRGGILADDMGLGKTLTTISLILANFT------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 726 pfLVVAPSSVVSVWAAEAEKFTPDLDVRVLDTTTRKRGTAVAdEVAGADVVVTSYTLLRIDAGQYGG-----LDWGGVVF 800
Cdd:cd18071 75 --LIVCPLSVLSNWETQFEEHVKPGQLKVYTYHGGERNRDPK-LLSKYDIVLTTYNTLASDFGAKGDsplhtINWLRVVL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 801 DEAQFLKNRAAKVHTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIeTGGDPERMAALRR 880
Cdd:cd18071 152 DEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSFLHLKPFSNPEYWRRLIQRPL-TMGDPTGLKRLQV 230
|
....*....
gi 1072319335 881 RVRPFMLRR 889
Cdd:cd18071 231 LMKQITLRR 239
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
675-889 |
1.48e-22 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 97.38 E-value: 1.48e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLAlFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTpDLDVRV 754
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSIT-FLYEILLTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAVADEVAGAD-------------VVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLR 821
Cdd:cd18061 79 YHGSLISRQMIQQYEMYFRDsqgriirgayrfqAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMN 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072319335 822 APFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYvtpietgGD---PERMAALRRRVRPFMLRR 889
Cdd:cd18061 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEF-------GDlktEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
675-889 |
5.44e-22 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 96.07 E-value: 5.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLrwlAFLWE--------QDLGGILADDMGLGKTVQTLALFAHA-RQ----ARPERPPFLVVAPSSVVSVWAA 741
Cdd:cd18066 1 LRPHQREGI---EFLYEcvmgmrvnERFGAILADEMGLGKTLQCISLIWTLlRQgpygGKPVIKRALIVTPGSLVKNWKK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 742 EAEKFTPDLDVRVLdttTRKRGTAVADEVAGA--DVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARD 819
Cdd:cd18066 78 EFQKWLGSERIKVF---TVDQDHKVEEFIASPlySVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTALTS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 820 LRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGGDP-----------ERMAALRRRVRPFMLR 888
Cdd:cd18066 155 LSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPtatpeekklgeARAAELTRLTGLFILR 234
|
.
gi 1072319335 889 R 889
Cdd:cd18066 235 R 235
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
970-1080 |
5.88e-22 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 91.89 E-value: 5.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 970 SKLERFLDDLTEviGEGHRVIVFSQFTSFLRviAEELDHLE-IEHAYLDGST--RGRADVIRGFREGEAPVfLISLKAGG 1046
Cdd:pfam00271 1 EKLEALLELLKK--ERGGKVLIFSQTKKTLE--AELLLEKEgIKVARLHGDLsqEEREEILEDFRKGKIDV-LVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 1072319335 1047 FGLTLTEADYVFLMDPWWNPAAEAQAVDRAHRIG 1080
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
675-889 |
6.32e-22 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 96.00 E-value: 6.32e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRwlaFLWE--------QDLGGILADDMGLGKTVQTLAL----FAHARQARPERPPFLVVAPSSVVSVWAAE 742
Cdd:cd18067 1 LRPHQREGVK---FLYRcvtgrrirGSHGCIMADEMGLGKTLQCITLmwtlLRQSPQCKPEIDKAIVVSPSSLVKNWANE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 743 AEKFT-PDLDVRVLDTTTRKRGTAVADEVAGAD-------VVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVH 814
Cdd:cd18067 78 LGKWLgGRLQPLAIDGGSKKEIDRKLVQWASQQgrrvstpVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 815 TVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGGDP-----------ERMAALRRRVR 883
Cdd:cd18067 158 QALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDAdasekerqlgeEKLQELISIVN 237
|
....*.
gi 1072319335 884 PFMLRR 889
Cdd:cd18067 238 RCIIRR 243
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
675-870 |
1.20e-19 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 88.95 E-value: 1.20e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRwlaFLWEQDLGGILADdMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFT--PDLDV 752
Cdd:cd18013 1 PHPYQKVAIN---FIIEHPYCGLFLD-MGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVARSTWPDEVEKWNhlRNLTV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 753 RVLDTTTRKRGTAVAdevAGADVVVTSYTLLRIDAGQYGGL-DWGGVVFDEAQFLKNRAAKVHTVARDLRAPFR--LAIT 829
Cdd:cd18013 77 SVAVGTERQRSKAAN---TPADLYVINRENLKWLVNKSGDPwPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKrlIGLT 153
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1072319335 830 GTPMENSLSDLWALLGVVVPG--LFPSHRRFRETYVTPIETGG 870
Cdd:cd18013 154 GTPSPNGLMDLWAQIALLDQGerLGRSITAYRERWFDPDKRNG 196
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
675-889 |
3.73e-19 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 87.92 E-value: 3.73e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLAFLWEQDL-GGILADDMGLGKTVQTLALFAHARQARPERPpflVVAPSSVVSVWAAEAEKFTPD---- 749
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPrGGILADDMGLGKTLTMIALILAQKNTQNRKE---EEKEKALTEWESKKDSTLVPSagtl 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 750 -----------------------LDVRVLDTTTRKRGTAVadeVAGADVVVTSYTLLRIDAGQYG---------GLDWGG 797
Cdd:cd18072 78 vvcpaslvhqwknevesrvasnkLRVCLYHGPNRERIGEV---LRDYDIVITTYSLVAKEIPTYKeesrssplfRIAWAR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 798 VVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETGGdpERMAA 877
Cdd:cd18072 155 IILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQVDNKSRKGG--ERLNI 232
|
250
....*....|..
gi 1072319335 878 LrrrVRPFMLRR 889
Cdd:cd18072 233 L---TKSLLLRR 241
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1002-1080 |
1.90e-17 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 78.02 E-value: 1.90e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 1002 IAEELDHLEIEHAYLDGST--RGRADVIRGFREGEApVFLISLKAGGFGLTLTEADYVFLMDPWWNPAAEAQAVDRAHRI 1079
Cdd:smart00490 3 LAELLKELGIKVARLHGGLsqEEREEILDKFNNGKI-KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRA 81
|
.
gi 1072319335 1080 G 1080
Cdd:smart00490 82 G 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
675-857 |
3.46e-16 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 78.30 E-value: 3.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRWLaflWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRV 754
Cdd:smart00487 9 LRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 755 LDTTTRKRGTAVADEVAG--ADVVVTSY-TLLR-IDAGQYGGLDWGGVVFDEAQFLKN--RAAKVHTVARDLR-APFRLA 827
Cdd:smart00487 86 VGLYGGDSKREQLRKLESgkTDILVTTPgRLLDlLENDKLSLSNVDLVILDEAHRLLDggFGDQLEKLLKLLPkNVQLLL 165
|
170 180 190
....*....|....*....|....*....|...
gi 1072319335 828 ITGTP---MENSLSDLWALLGVVVPGLFPSHRR 857
Cdd:smart00487 166 LSATPpeeIENLLELFLNDPVFIDVGFTPLEPI 198
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
675-869 |
4.24e-15 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 76.01 E-value: 4.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRwlaFLWE------------QDLGGILADDMGLGKTVQTLALFAHARQARPERPpFLVVAPSSVVSVWAAE 742
Cdd:cd18069 1 LKPHQIGGIR---FLYDniieslerykgsSGFGCILAHSMGLGKTLQVISFLDVLLRHTGAKT-VLAIVPVNTLQNWLSE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 743 AEKFTP-----------DLDVRVLD---TTTRKRGTAVADEVAGADVVVTSYTLLRIDAGQyggldwGGVVFDEAQFLKN 808
Cdd:cd18069 77 FNKWLPppealpnvrprPFKVFILNdehKTTAARAKVIEDWVKDGGVLLMGYEMFRLRPGP------DVVICDEGHRIKN 150
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072319335 809 RAAKVHTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETG 869
Cdd:cd18069 151 CHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNG 211
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
675-869 |
1.64e-13 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 71.46 E-value: 1.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRwlaFLWE------------QDLGGILADDMGLGKTVQTLAlFAHARQARPERPPF---LVVAPSSVVSVW 739
Cdd:cd18068 1 LKPHQVDGVQ---FMWDccceslkktkksPGSGCILAHCMGLGKTLQVVT-FLHTVLLCEKLENFsrvLVVCPLNTVLNW 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 740 AAEAEKF------TPDLDVRVLDTTTRK--RGTAVADEVAGADVVVTSYTLLRI------------------DAGQYGGL 793
Cdd:cd18068 77 LNEFEKWqeglkdEEKIEVNELATYKRPqeRSYKLQRWQEEGGVMIIGYDMYRIlaqernvksreklkeifnKALVDPGP 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1072319335 794 DWggVVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIETG 869
Cdd:cd18068 157 DF--VVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNG 230
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
632-1128 |
1.65e-13 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 74.68 E-value: 1.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 632 FWEDLKELADEVDEDPEWTAAVGRLAAVERLPEAPRPAGLKADLRPYQEEGL-RWLAFLWEQDLGGILADDMGLGKTVqt 710
Cdd:COG1061 38 RRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEASGTSFELRPYQQEALeALLAALERGGGRGLVVAPTGTGKTV-- 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 711 LALFAHARQARPER-----PpflvvaPSSVVSVWAAEAEKFTPDldvrVLDTTTRKRgtavadevAGADVVVTSY-TLLR 784
Cdd:COG1061 116 LALALAAELLRGKRvlvlvP------RRELLEQWAEELRRFLGD----PLAGGGKKD--------SDAPITVATYqSLAR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 785 IDAGQYGGLDWGGVVFDEAQFLknRAAKVHTVARDLRAPFRLAITGTP--MENSLSDLWALLGVVvpglfpshrrFRETY 862
Cdd:COG1061 178 RAHLDELGDRFGLVIIDEAHHA--GAPSYRRILEAFPAAYRLGLTATPfrSDGREILLFLFDGIV----------YEYSL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 863 vtpietggdpermaalrrrvrpfmlrrsKELVAKDLpskqeqilqveLEPAHRKLYDRVLQRERrkvlgllgdmdgNRFT 942
Cdd:COG1061 246 ----------------------------KEAIEDGY-----------LAPPEYYGIRVDLTDER------------AEYD 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 943 IFTsltllrmlalapQIVDDQYASVPSSKLERfLDDLTEVIGEGHRVIVFSQFTSFLRVIAEELDHLEIEHAYLDGST-- 1020
Cdd:COG1061 275 ALS------------ERLREALAADAERKDKI-LRELLREHPDDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTpk 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 1021 RGRADVIRGFREGEAPVfLISLKAGGFGLTLTEADYVFLMDPWWNPAAEAQAVDRAHRIGQ-ERTVMVYRLVSEGT-IEE 1098
Cdd:COG1061 342 KEREEILEAFRDGELRI-LVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPgKEDALVYDFVGNDVpVLE 420
|
490 500 510
....*....|....*....|....*....|
gi 1072319335 1099 KVLELQRRKAELFGALMDESDDSGAGAFTD 1128
Cdd:COG1061 421 ELAKDLRDLAGYRVEFLDEEESEELALLIA 450
|
|
| SWIM |
COG4715 |
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown]; |
16-518 |
7.71e-10 |
|
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];
Pssm-ID: 443750 [Multi-domain] Cd Length: 508 Bit Score: 62.92 E-value: 7.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 16 EAIRAVVGPTSADRGFAVAASGAVGRLRYDAatGRLSASVQGTapSPYRVQVQLQEAYDdaaedgagalmepVGGRCTCP 95
Cdd:COG4715 9 DDIRRLAGPRIFERGREYAREGRVLDLDVED--GRLEATVQGS--EDYRVRVDLDDGGD-------------LDSSCTCP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 96 VGTD--CKHVAAALYQVVRLDAD-QALDDARRKLAEMV------TTADALPAPAGRGHDGGGPAGLDAPAADGAAPPPPA 166
Cdd:COG4715 72 YGGGgfCKHVVAVLLALLDQPEEgAPRQSEREALEELLerlskeELVELLLELAAEDPELRELRRALDDSGGDYLREELL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 167 GLDWRRVMEPLAGLHGPRRVGTPPALAIGVELVAESSRNAFQQWGPATAGEEQVREGRPLYVTVRPLKRGAKGT-----W 241
Cdd:COG4715 152 ELSRLAALSLTATLAALAPRSTLALRLALLRLLLLLLAPSSLDGAPPGLSLALVRELLPALAERALALLLLVPApagllK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 242 IKGGLTWKAFQFPRAEFAPAQERAMRLIWRQVQAEDSYPGDAWFGLHVFDSPRIWQLLAEAREVGVELVPLGLLTDVVLE 321
Cdd:COG4715 232 LRLLLARPGALLLSLLDLLLRLDLLLGLLLLALLLLLLLLLQLLALLLLALRTLAALLLLLRLRLRLGLAAGLALAVLLL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 322 APVAVGLDVTAAPDGGLDVAPSLDPAPPGPGLSGVHAVGGIGFYRVELTDEEAVLHLIPAARPVPEAVQQLVLAGGPVRV 401
Cdd:COG4715 312 LLLLLLPLPLALLALSLLLRLLLALLRLALLVLLYLLLILLLLALLLLALLLLLELLLLLALLLLLAEVELARLLEEALL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 402 PAADREEFLGRIYPRLRGALPVTSGDASVELPEFEPPVLRLRADFRPGHELVLRWSWLYFDPPRELGLDAGGDPLRDTRH 481
Cdd:COG4715 392 IRRRLLLLLLLLLRLLDLLALLALRLLLLLLLAVLSEAEDLLLELLETLGLHRLLLLEAREELLPELAADLALLLLLEAL 471
|
490 500 510
....*....|....*....|....*....|....*..
gi 1072319335 482 EDAVLRAVAELWPRAGRAEEQVLEGVGAARFSEQVLP 518
Cdd:COG4715 472 DLLALEALALLLLLELLLLLAVTLLLLAIDELLLLAL 508
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
675-867 |
3.77e-09 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 58.07 E-value: 3.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGLRwlAFLWEQDLGGILADDMGLGKTVQTLALfAHARQARPERPPFLVVAPSSVVSVWAAE-AEKFtpDLDVR 753
Cdd:cd18011 1 PLPHQIDAVL--RALRKPPVRLLLADEVGLGKTIEAGLI-IKELLLRGDAKRVLILCPASLVEQWQDElQDKF--GLPFL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 754 VLDTTTRKRGTAVADEVAGA-DVVVTSYTLLRIDAGQYGGL---DWGGVVFDEAQFLKNRAAKVHT----VARDL--RAP 823
Cdd:cd18011 76 ILDRETAAQLRRLIGNPFEEfPIVIVSLDLLKRSEERRGLLlseEWDLVVVDEAHKLRNSGGGKETkrykLGRLLakRAR 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1072319335 824 FRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPIE 867
Cdd:cd18011 156 HVLLLTATPHNGKEEDFRALLSLLDPGRFAVLGRFLRLDGLREV 199
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
675-832 |
9.61e-09 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 55.39 E-value: 9.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGL-RWLAFlwEQDLGGILADDMGLGKTVQTLALFAHarqaRPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVR 753
Cdd:cd17926 1 LRPYQEEALeAWLAH--KNNRRGILVLPTGSGKTLTALALIAY----LKELRTLIVVPTDALLDQWKERFEDFLGDSSIG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 754 VLdtttrkrGTAVADEVAGADVVVTSYTLLRIDA--GQYGGLDWGGVVFDEAQFLKNRAAKVhtVARDLRAPFRLAITGT 831
Cdd:cd17926 75 LI-------GGGKKKDFDDANVVVATYQSLSNLAeeEKDLFDQFGLLIVDEAHHLPAKTFSE--ILKELNAKYRLGLTAT 145
|
.
gi 1072319335 832 P 832
Cdd:cd17926 146 P 146
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
969-1107 |
1.12e-07 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 56.28 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 969 SSKLERFLDDLTEVIGE--GHRVIVFSQFTSFLRVIAEELDHLEIEHAYLDG-STRG---------RADVIRGFREGEAP 1036
Cdd:COG1111 334 HPKLSKLREILKEQLGTnpDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGqASKEgdkgltqkeQIEILERFRAGEFN 413
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072319335 1037 VfLISLKAGGFGLTLTEADYVFLMDPWWNpaaEAQAVDRAHRIGQERTVMVYRLVSEGTIEEKVLELQRRK 1107
Cdd:COG1111 414 V-LVATSVAEEGLDIPEVDLVIFYEPVPS---EIRSIQRKGRTGRKREGRVVVLIAKGTRDEAYYWSSRRK 480
|
|
| COG4279 |
COG4279 |
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown]; |
29-141 |
1.18e-07 |
|
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];
Pssm-ID: 443420 Cd Length: 193 Bit Score: 53.42 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 29 RGFAVAASGAVGRLryDAATGRLSASVQGTAPSPYRVQVQLQ------------------------------EAYDDAAE 78
Cdd:COG4279 33 RGRSYARNGRVLSL--KIEPGRVTARVQGSRPEPYRVSIRLPpfsdedwdrviatlagragflaallagempEEIEEAFE 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 79 DGAGAL----MEPVGGRCTCPVGTD-CKHVAAALYQV-VRLDAD-------------QALDDAR-RKLAEMVTTADALPA 138
Cdd:COG4279 111 AAGLSLfpssPRDLRTDCSCPDWANpCKHIAAVYYLLaERLDEDpfllfqlrgrdreELLAALReRRAGGALAPAGSASE 190
|
...
gi 1072319335 139 PAG 141
Cdd:COG4279 191 TAY 193
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
675-832 |
1.59e-05 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 46.51 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 675 LRPYQEEGL-RWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVR 753
Cdd:pfam04851 4 LRPYQIEAIeNLLESIKNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPRKDLLEQALEEFKKFLPNYVEI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 754 VLDTTTRKRgtavADEVAGADVVVTSY-TLLRIDAG---QYGGLDWGGVVFDEA---QFLKNRAAKVHtvardLRAPFRL 826
Cdd:pfam04851 84 GEIISGDKK----DESVDDNKIVVTTIqSLYKALELaslELLPDFFDVIIIDEAhrsGASSYRNILEY-----FKPAFLL 154
|
....*.
gi 1072319335 827 AITGTP 832
Cdd:pfam04851 155 GLTATP 160
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
970-1055 |
8.45e-05 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 44.16 E-value: 8.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 970 SKLERfLDDLTEVIGEGHRVIVFSQFTSFLRVIAEELDHLEIEHAYldgSTRGRADVIRGFREGEAPVFLISlKAGGFGL 1049
Cdd:cd18789 34 NKLRA-LEELLKRHEQGDKIIVFTDNVEALYRYAKRLLKPFITGET---PQSEREEILQNFREGEYNTLVVS-KVGDEGI 108
|
....*.
gi 1072319335 1050 TLTEAD 1055
Cdd:cd18789 109 DLPEAN 114
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
1038-1082 |
3.38e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 40.38 E-value: 3.38e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1072319335 1038 FLISLKAGGFGLTLTEADYVFLMDPWWNPAAEAQAVDRAHRIGQE 1082
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKD 69
|
|
| SNF2_assoc |
pfam08455 |
Bacterial SNF2 helicase associated; This domain is found in bacterial proteins of the SWF/SNF ... |
328-611 |
3.48e-04 |
|
Bacterial SNF2 helicase associated; This domain is found in bacterial proteins of the SWF/SNF/SWI helicase family to the N-terminus of the SNF2 family N-terminal domain (pfam00176) and together with the Helicase conserved C-terminal domain (pfam00271). The function of the domain is not clear.
Pssm-ID: 462483 Cd Length: 370 Bit Score: 44.14 E-value: 3.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 328 LDVTAAPDGGLDVAPSLDPAPPGPglSGVHAVGGIGFYRVELTDEEAV--LHLIPAARPVPEavqqlvlaggpVRVPAAD 405
Cdd:pfam08455 44 FSLKKEKDDGIILTLNKDPILLGE--DYLYFLYDGTIYRLSKEQCKLLspLLKLLNLLGTKE-----------ITISKED 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 406 REEFLGRIYPRLRGALPVTSGDASVELPEFEPPVLRLRADfRPGHELVLRWSWLY----FDPPRELGLdaggdpLRDTRH 481
Cdd:pfam08455 111 LPKFLSEVLPKLKKIGEVEIPEELLEKYVPEPLKAKFYLD-RDDDRITARVKFQYgdieFNPLEDLIL------VRDVEK 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 482 EDAVLRAVAELwPRAGRAEEQVLEGVGAA-RFSEQVLPLLQRADHVRVdvtGDRPDYRELKAAPRIEVGTK-ATQNDWFD 559
Cdd:pfam08455 184 EAKILNLLEQY-GFKVDDGKFYLDDEEKIyDFLTEGLPKLQELGEVYY---SDAFKNLKVKPSPSVSVGVSvDEEGNLLE 259
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1072319335 560 lgVQVSVDGhvLPFVEL---FTALVQGRTTLILADGSYLGLDHPAFDRLRALLSE 611
Cdd:pfam08455 260 --ISFDIDG--IDEEELaniLQALREKKKYYRLKDGSFLDLEEEELKELSELLDE 310
|
|
| EntF |
COG1020 |
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ... |
365-822 |
3.51e-04 |
|
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 44.85 E-value: 3.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 365 YRVELTDEEAVLHLIPA-------ARPVPEAVQQLVLaggpVRVPAADREEFLGRIYPRLRGALPVTSGDASVELPEFEP 437
Cdd:COG1020 881 FRIELGEIEAALLQHPGvreavvvAREDAPGDKRLVA----YVVPEAGAAAAAALLRLALALLLPPYMVPAAVVLLLPLP 956
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 438 PVLRLRADFRPghelvlrwswlyfDPPRELGLDAGGDPLRDTRHEDAVLRAVAELWPRAGRAEEQVLEGVGAARFSEQVL 517
Cdd:COG1020 957 LTGNGKLDRLA-------------LPAPAAAAAAAAAAPPAEEEEEEAALALLLLLVVVVGDDDFFFFGGGLGLLLLLAL 1023
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 518 PLLQRADHVRVDVTGDRPDYRELKAAPRIEVGTKATQNDWFDLGVQVSVDGHVLPFVELFTALVQGRTTLILADGSYLGL 597
Cdd:COG1020 1024 ARAARLLLLLLLLLLLFLAAAAAAAAAAAAAAAAAAAAPLAAAAAPLPLPPLLLSLLALLLALLLLLALLALLALLLLLL 1103
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 598 DHPAFDRLRALLSEAATLQEWTPEHTPVSRHQVGFWEDLKELADEVDEDPEWTAAVGRLAAVERLPEAPRPAGLKADLRP 677
Cdd:COG1020 1104 LLLLLLALLLLLALLLALLAALRARRAVRQEGPRLRLLVALAAALALAALLALLLAAAAAAAELLAAAALLLLLALLLLA 1183
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 678 YQEEGLRWLAFLWEQDLGGILADDMGLGKTVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRVLDT 757
Cdd:COG1020 1184 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLAAAAAALLALALLLALLALAALLALAALAALAAALLALA 1263
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1072319335 758 TTRKRGTAVADEVAGADVVVTSYTLLRIDAGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRA 822
Cdd:COG1020 1264 LALLALALLLLALALLLPALARARAARTARALALLLLLALLLLLALALALLLLLLLLLALLLLAL 1328
|
|
| PksD |
COG3321 |
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
476-1029 |
1.11e-03 |
|
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 43.32 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 476 LRDTRHEDA-VLRAVAELWPRAGRAEEQVLEGVGAAR--------FSEQVLPLLQRADHVRVDVTGDRPDYRELKAAPRI 546
Cdd:COG3321 823 LRRGEDELAqLLTALAQLWVAGVPVDWSALYPGRGRRrvplptypFQREDAAAALLAAALAAALAAAAALGALLLAALAA 902
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 547 EVGTKATQNDWFDLGVQVSVDGHVLPFVELFTALVQGRTTLILADGSYLGLDHPAFDRLRALLSEAATLQEWTPEHTPVS 626
Cdd:COG3321 903 ALAAALLALAAAAAAALALAAAALAALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAA 982
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 627 RHQVGFWEDLKELADEVDEDPEWTAAVGRLAAVERLPEAPRPAGLKADLRPYQEEGLRWLAFLWEQDLGGILADDMGLGK 706
Cdd:COG3321 983 AAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALA 1062
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 707 TVQTLALFAHARQARPERPPFLVVAPSSVVSVWAAEAEKFTPDLDVRVLDTTTRKRGTAVADEVAGADVVVTSYTLLRID 786
Cdd:COG3321 1063 LALAALLLLAALAELALAAAALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAA 1142
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 787 AGQYGGLDWGGVVFDEAQFLKNRAAKVHTVARDLRAPFRLAITGTPMENSLSDLWALLGVVVPGLFPSHRRFRETYVTPI 866
Cdd:COG3321 1143 AAAAAAALALAAAAAALAAALAAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAA 1222
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 867 ETGGDPERMAALRRRVRPFMLRRSKELVAKDLPSKQEQILQVELEPAHRKLYDRVLQRERRKVLGLLGDMDGNRFTIFTS 946
Cdd:COG3321 1223 LLAAAAAAAALALLALAAAAAAVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALL 1302
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 947 LTLLRMLALAPQIVDDQYASVPSSKLERFLDDLTEVIGEGHRVIVFSQFTSFLRVIAEELDHLEIEHAYLDGSTRGRADV 1026
Cdd:COG3321 1303 AAAAAAAAAAAAAAAAAALAAALLAAALAALAAAVAAALALAAAAAAAAAAAAAAAAAAALAAAAGAAAAAAALALAALA 1382
|
...
gi 1072319335 1027 IRG 1029
Cdd:COG3321 1383 AAV 1385
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
970-1087 |
5.14e-03 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 38.49 E-value: 5.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072319335 970 SKLERFLDDLTEVIGEGH--RVIVFSQFTSFLRVIAEELD--------HLEIEHA---YLDG-STRGRADVIRGFREGEA 1035
Cdd:cd18801 12 EKLEEIVKEHFKKKQEGSdtRVIIFSEFRDSAEEIVNFLSkirpgiraTRFIGQAsgkSSKGmSQKEQKEVIEQFRKGGY 91
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1072319335 1036 PVfLISLKAGGFGLTLTEADYVFLMDPWWNPAAEAQAVDRAHRIGQERTVMV 1087
Cdd:cd18801 92 NV-LVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGRKRQGRVVVL 142
|
|
| |
