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Conserved domains on  [gi|1067236662|ref|WP_069556950|]
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MULTISPECIES: lipopolysaccharide assembly protein LapB [Pseudomonas]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-80 6.65e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.49  E-value: 6.65e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAA 80
Cdd:COG2956   130 IEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD 208
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-80 6.65e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.49  E-value: 6.65e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAA 80
Cdd:COG2956   130 IEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD 208
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 5-80 1.41e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 36.21  E-value: 1.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1067236662   5 LEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAA 80
Cdd:TIGR02917 352 LSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLD 427
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 2-91 2.05e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 35.68  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAwKLLGKAQLGQGDNagARHAWEKGIEAAL 81
Cdd:cd24142    20 LKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYE-KYLYLGQLSGGEE--ALQYYEKGIEILE 96

                          90
                  ....*....|
gi 1067236662  82 AHGDKQAEKE 91
Cdd:cd24142    97 EELQALQAAS 106
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-80 6.65e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.49  E-value: 6.65e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAA 80
Cdd:COG2956   130 IEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD 208
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 2-75 2.50e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.69  E-value: 2.50e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEK 75
Cdd:COG4235    37 LAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQK 110
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 2-85 3.07e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAAL 81
Cdd:COG4783    24 EALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDP 103


                  ....
gi 1067236662  82 AHGD 85
Cdd:COG4783   104 EHPE 107
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 3-80 9.46e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 9.46e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1067236662   3 ESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAA 80
Cdd:COG2956    97 ELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLD 174
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1-101 1.29e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.76  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067236662   1 MLESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIeaA 80
Cdd:COG4235     2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERAL--A 79

                          90       100
                  ....*....|....*....|.
gi 1067236662  81 LAHGDKQAEKEMAVFLKKLDR 101
Cdd:COG4235    80 LDPDNPEALYLLGLAAFQQGD 100
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
2-85 2.34e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 2.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAAL 81
Cdd:COG0457    62 LADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDP 141


                  ....
gi 1067236662  82 AHGD 85
Cdd:COG0457   142 DDAD 145
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 2-80 2.64e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.18  E-value: 2.64e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAA 80
Cdd:COG4783    58 IVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
2-103 6.36e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 6.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAAL 81
Cdd:COG0457    96 LEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAAL 175

                          90       100
                  ....*....|....*....|..
gi 1067236662  82 AHGDKQAEKEMAVFLKKLDRQA 103
Cdd:COG0457   176 AALLAAALGEAALALAAAEVLL 197
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
3-103 1.34e-04

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 39.09  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067236662   3 ESLEKMLAKGVDnslLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKY--SAAWKLLGKAQLGQGDNAGARHAWEKgieAA 80
Cdd:COG4700   114 EALTGIFADDPH---ILLGLAQALFELGRYAEALETLEKLIAKNPDFksSDAHLLYARALEALGDLEAAEAELEA---LA 187

                          90       100
                  ....*....|....*....|...
gi 1067236662  81 LAHGDKQAEKEMAVFLKKLDRQA 103
Cdd:COG4700   188 RRYSGPEARYRYAKFLARQGRTA 210
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
2-78 1.98e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.45  E-value: 1.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIE 78
Cdd:COG0457    28 IEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALE 104
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-80 3.43e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.79  E-value: 3.43e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAA 80
Cdd:COG2956   164 IEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELD 242
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
14-78 5.11e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 37.29  E-value: 5.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1067236662  14 DNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIE 78
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE 70
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 2-80 9.62e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 36.48  E-value: 9.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAA 80
Cdd:COG5010    74 LALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
2-80 1.00e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.15  E-value: 1.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEhLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAA 80
Cdd:COG3063    12 EEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELD 89
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 2-82 1.04e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 36.43  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYsAAWKLLGKAQLGQGDNAGARHAWEKGIEAAL 81
Cdd:COG3071   244 LKRAEKWLKKHPNDPDLLLALGRLCLRNQLWGKAREYLEAALALRPSA-EAYAELARLLEQLGDPEEAAEHYRKALALAL 322


                  .
gi 1067236662  82 A 82
Cdd:COG3071   323 G 323
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-80 1.14e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 36.25  E-value: 1.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDnagarhaWEKGIEAA 80
Cdd:COG2956    62 IRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGD-------WEKAIEVL 133
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
14-80 1.40e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 36.05  E-value: 1.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1067236662  14 DNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAA 80
Cdd:COG4785   105 DLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 5-80 1.41e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 36.21  E-value: 1.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1067236662   5 LEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAA 80
Cdd:TIGR02917 352 LSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLD 427
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 2-91 2.05e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 35.68  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAwKLLGKAQLGQGDNagARHAWEKGIEAAL 81
Cdd:cd24142    20 LKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYE-KYLYLGQLSGGEE--ALQYYEKGIEILE 96

                          90
                  ....*....|
gi 1067236662  82 AHGDKQAEKE 91
Cdd:cd24142    97 EELQALQAAS 106
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 5-84 2.25e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 35.83  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067236662   5 LEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEAALAHG 84
Cdd:TIGR02917 556 LEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSA 635
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
26-78 3.11e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 35.28  E-value: 3.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1067236662  26 YLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIE 78
Cdd:COG4785    83 YDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALE 135
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 19-75 4.39e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 33.81  E-value: 4.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067236662  19 RFGLGKGYLDLKDNAKAAEHLQRCVEFDP---KYSAAWKLLGKAQLGQGDNAGARHAWEK 75
Cdd:COG1729    33 LYWLGEAYYALGDYDEAAEAFEKLLKRYPdspKAPDALLKLGLSYLELGDYDKARATLEE 92
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-78 4.56e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 34.70  E-value: 4.56e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1067236662   2 LESLEKMLAKGVDNSLLRFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIE 78
Cdd:COG2956    28 IDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLE 104
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
26-70 4.83e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 33.61  E-value: 4.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1067236662  26 YLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGAR 70
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI 46
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 19-101 8.86e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 33.24  E-value: 8.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067236662  19 RFGLGKGYLDLKDNAKAAEHLQRCVEFDPKYSAAWKLLGKAQLGQGDNAGARHAWEKGIEaaLAHGDKQAEKEMAVFLKK 98
Cdd:COG4783     7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALE--LDPDEPEARLNLGLALLK 84


                  ...
gi 1067236662  99 LDR 101
Cdd:COG4783    85 AGD 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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