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Conserved domains on  [gi|1056282013|ref|WP_067748835|]
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MULTISPECIES: carbohydrate ABC transporter permease [unclassified Mycobacterium]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 11417684)

carbohydrate ABC transporter permease, part of a periplasmic binding protein (PBP)-dependent ABC transporter may be involved in transport of one or more of a variety of mono-, di-, or polysaccharides, such as trehalose/maltose (MalG) and alginate (AlgM); responsible for translocation of the substrate across the membrane

Gene Ontology:  GO:0055085|GO:0008643
PubMed:  19234479|27273632
TCDB:  3.A.1.1.

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 3-280 7.31e-106

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 308.56  E-value: 7.31e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013   3 SAERLFTRNVVRAVLVYTALIAIAWCWLFPIAWAVSGSLKREGEI--TEPKLLPAHPRWSNYTEVFSLMPFARMFFNTVL 80
Cdd:COG0395     2 SATARRRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIfsGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  81 YAGCVTAGQVFFCSLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVGWVDTPWSMIVPGL-FGSAFGTY 159
Cdd:COG0395    82 VAVVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLaFGLPFGIF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 160 LMRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMLQRNSLATLTLGLVRLRGE 239
Cdd:COG0395   162 LLRQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQ 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1056282013 240 YVARWPIIMATSMLIMLPLVLIYAIAQRSFVRGIAVTGLNG 280
Cdd:COG0395   242 YGTDWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 3-280 7.31e-106

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 308.56  E-value: 7.31e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013   3 SAERLFTRNVVRAVLVYTALIAIAWCWLFPIAWAVSGSLKREGEI--TEPKLLPAHPRWSNYTEVFSLMPFARMFFNTVL 80
Cdd:COG0395     2 SATARRRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIfsGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  81 YAGCVTAGQVFFCSLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVGWVDTPWSMIVPGL-FGSAFGTY 159
Cdd:COG0395    82 VAVVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLaFGLPFGIF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 160 LMRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMLQRNSLATLTLGLVRLRGE 239
Cdd:COG0395   162 LLRQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQ 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1056282013 240 YVARWPIIMATSMLIMLPLVLIYAIAQRSFVRGIAVTGLNG 280
Cdd:COG0395   242 YGTDWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
19-273 1.45e-33

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 123.31  E-value: 1.45e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  19 YTALIAIAWCWLFPIAWA-VSGSLKREGEITEP-KLLPAHPRWSNYTEVF------SLMPFARMFFNTVLYAGCVTAGQV 90
Cdd:PRK10973   13 HTMLILGIAVILFPLYVAfVAATLDKQAVFAVPmTLIPGTHLLENIANIWvngvgnNSAPFGRMLLNSFVMAFSITVGKI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  91 FFCSLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVGWVDTPWSMIVPgLFGSAFGTYLMRQFFRTLPT 170
Cdd:PRK10973   93 TVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLP-LMASATATFLFRQFFMTLPD 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 171 DLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMLQRNSLATLTLGLVRL--RGEYVARWPIIM 248
Cdd:PRK10973  172 ELVEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKGMiaTGEGTTEWNQVM 251

                         250       260
                  ....*....|....*....|....*
gi 1056282013 249 ATSMLIMLPLVLIYAIAQRSFVRGI 273
Cdd:PRK10973  252 AAMLLTLIPPVVIVLAMQRAFVRGL 276
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 75-257 3.10e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 77.70  E-value: 3.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  75 FFNTVLYAGCVTAGQVFFCSLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVGWVDTPWSMIVPGL--- 151
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALila 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 152 --FGSAFGTYLMRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMLQRNSLATL 229
Cdd:cd06261    81 llLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                         170       180
                  ....*....|....*....|....*...
gi 1056282013 230 TLGLVRLRGEYVARWPIIMATSMLIMLP 257
Cdd:cd06261   161 TGLLLIFAILFPGDLGVAAAVALILLLL 188
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 95-275 9.98e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 65.01  E-value: 9.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  95 LAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVGWVDTPWSMIVPGLFGSA-FGTYLMRQFFRTLPTDLE 173
Cdd:pfam00528   4 LGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAgYARLIRRAALRSLPSDLV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 174 EAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMLQRNSLATLTLGLVRLRGEYVARWPIIMATsmL 253
Cdd:pfam00528  84 EAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAA--L 161

                         170       180
                  ....*....|....*....|..
gi 1056282013 254 IMLPLVLIYAIAQRSFVRGIAV 275
Cdd:pfam00528 162 ILLLLNLLVDILQRLLDPRVRK 183
Mo_ABC_porter TIGR01581
NifC-like ABC-type porter; This model describes a clade of ABC porter genes with relatively ...
 98-207 3.43e-04

NifC-like ABC-type porter; This model describes a clade of ABC porter genes with relatively weak homology compared to its neighbor clades, the molybdate (TIGR02141) and sulfate (TIGR00969) porters. Neighbor-Joining, PAM-distance phylogenetic trees support the separation of the clades in this way. Included in this group is a gene designated NifC in Clostridium pasturianum. It would be reasonable to presume that NifC acts as a molybdate porter since the most common form of nitrogenase is a molybdoenzyme. Several other sequences falling within the scope of this model are annotated as molybdate porters and one, from Halobacterium, is annotated as a sulfate porter. There is presently no experimental evidence to support annotations with this degree of specificity.


Pssm-ID: 130643  Cd Length: 225  Bit Score: 40.84  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  98 YAFARLEFRGRDTLFVLYLGTLMVPLTVT------------VIPQFILMRTVGWVDTPWSMIVPGLF-GSAFGTYLMRQF 164
Cdd:TIGR01581  46 YVLARVRFPLKKLLDTLLDLPMVLPPLVAglallllfgrngLLGPYLEAAGIQVIFSTLGVVLAQTFvASPYYVRVARST 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1056282013 165 FRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTW 207
Cdd:TIGR01581 126 FKSVDPRYEDVARSLGAGPLETFRKITLPMARPGLLAGLVLAW 168
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 3-280 7.31e-106

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 308.56  E-value: 7.31e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013   3 SAERLFTRNVVRAVLVYTALIAIAWCWLFPIAWAVSGSLKREGEI--TEPKLLPAHPRWSNYTEVFSLMPFARMFFNTVL 80
Cdd:COG0395     2 SATARRRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIfsGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  81 YAGCVTAGQVFFCSLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVGWVDTPWSMIVPGL-FGSAFGTY 159
Cdd:COG0395    82 VAVVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLaFGLPFGIF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 160 LMRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMLQRNSLATLTLGLVRLRGE 239
Cdd:COG0395   162 LLRQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQ 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1056282013 240 YVARWPIIMATSMLIMLPLVLIYAIAQRSFVRGIAVTGLNG 280
Cdd:COG0395   242 YGTDWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 1-274 4.74e-69

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 215.02  E-value: 4.74e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013   1 MASAERLFTRNVVRAVLVYTALIAIAWCWLFPIAWAVSGSLKREGEITEPKLLPAHPRWSNYTEVFSLMPFARMFFNTVL 80
Cdd:COG3833     1 MSRRKSRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLIPENFTLENYKKLFTETPFLRWFLNSLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  81 YAGCVTAGQVFFCSLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVGWVDTPWSMIVPGLFGS-AFGTY 159
Cdd:COG3833    81 VAVVTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYLGGAiPFNTW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 160 LMRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMLQRNSLATLTLGLVRL-RG 238
Cdd:COG3833   161 LMKGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFvSD 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1056282013 239 EYVARWPIIMATSMLIMLPLVLIYAIAQRSFVRGIA 274
Cdd:COG3833   241 QRNTNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLT 276
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
19-273 1.45e-33

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 123.31  E-value: 1.45e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  19 YTALIAIAWCWLFPIAWA-VSGSLKREGEITEP-KLLPAHPRWSNYTEVF------SLMPFARMFFNTVLYAGCVTAGQV 90
Cdd:PRK10973   13 HTMLILGIAVILFPLYVAfVAATLDKQAVFAVPmTLIPGTHLLENIANIWvngvgnNSAPFGRMLLNSFVMAFSITVGKI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  91 FFCSLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVGWVDTPWSMIVPgLFGSAFGTYLMRQFFRTLPT 170
Cdd:PRK10973   93 TVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLP-LMASATATFLFRQFFMTLPD 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 171 DLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMLQRNSLATLTLGLVRL--RGEYVARWPIIM 248
Cdd:PRK10973  172 ELVEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKGMiaTGEGTTEWNQVM 251

                         250       260
                  ....*....|....*....|....*
gi 1056282013 249 ATSMLIMLPLVLIYAIAQRSFVRGI 273
Cdd:PRK10973  252 AAMLLTLIPPVVIVLAMQRAFVRGL 276
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 59-267 1.08e-21

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 91.33  E-value: 1.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  59 WSNYTEVFSLMPFARMFFNTVLYAGCVTAGQVFFCSLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVG 138
Cdd:COG1177    47 LRWYAELFSDPRLLDALLNSLLIALLSTLLATVLGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALG 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 139 WVDTPWSMIVP-GLFGSAFGTYLMRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWP 217
Cdd:COG1177   127 LSGGLWGLILAhVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVIT 206

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1056282013 218 lLMLQRNSLATLTLGLVRLRGEYVArwPIIMATSMLIMLPLVLIYAIAQR 267
Cdd:COG1177   207 -LFLAGPGVTTLPVYIYSMIRRGIS--PEINALSTLLILLSLLLLLLAER 253
malG PRK10998
maltose ABC transporter permease MalG;
15-280 1.45e-20

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 89.00  E-value: 1.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  15 AVLVYTALIaiawcwLFPIAWAVSGSLkREGEITEPKLLPAHPRWSNYTEVFSL-------------MPFARMFFNTVLY 81
Cdd:PRK10998   19 LLLGFIALI------MFPLLMVIAISL-REGNFATGSLIPEQISWEHWKLALGFsvehadgrvtpppFPVLLWLWNSVKV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  82 AGCVTAGQVFFCSLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVG------WVDTPWSMIVPGLFGSA 155
Cdd:PRK10998   92 AGITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGqyipfiGLNTHGGVIFAYLGGIA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 156 FGTYLMRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMLQRNSLATLTLGLVR 235
Cdd:PRK10998  172 LHVWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLRDVNSYTLAVGMQQ 251

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1056282013 236 LRGEYVARWPIIMATSMLIMLPLVLIYAIAQRSFVRGIAVTGLNG 280
Cdd:PRK10998  252 YLNPQNYLWGDFAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVKG 296
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 75-257 3.10e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 77.70  E-value: 3.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  75 FFNTVLYAGCVTAGQVFFCSLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVGWVDTPWSMIVPGL--- 151
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALila 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 152 --FGSAFGTYLMRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMLQRNSLATL 229
Cdd:cd06261    81 llLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                         170       180
                  ....*....|....*....|....*...
gi 1056282013 230 TLGLVRLRGEYVARWPIIMATSMLIMLP 257
Cdd:cd06261   161 TGLLLIFAILFPGDLGVAAAVALILLLL 188
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
21-220 3.87e-14

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 70.93  E-value: 3.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  21 ALIAIAWCWLFPIAWAVSGSLkregeiTEPKLLPAHPRW---SNYTEVFSLMPFARMFFNTVLYAGCVTAGQVFFcslaG 97
Cdd:COG1175    27 ALLLLLVFVLYPLLYTLYLSF------TDWNLLGPPPEFvglDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVL----G 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  98 YAFARL---EFRGRDTLFVLYLGTLMVPLTVTVI-------PQF----ILMRTVGWVDTPW---------SMIVPGLF-G 153
Cdd:COG1175    97 LLLALLlnrKLRGRGFFRTLFFLPWVISPVVVALiwkwlfnPDYgllnALLGALGLEPINWlgdpslalpAVIIVTVWkG 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1056282013 154 SAFGTYLMRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLM 220
Cdd:COG1175   177 TGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVL 243
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 95-275 9.98e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 65.01  E-value: 9.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  95 LAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVGWVDTPWSMIVPGLFGSA-FGTYLMRQFFRTLPTDLE 173
Cdd:pfam00528   4 LGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAgYARLIRRAALRSLPSDLV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 174 EAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMLQRNSLATLTLGLVRLRGEYVARWPIIMATsmL 253
Cdd:pfam00528  84 EAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAA--L 161

                         170       180
                  ....*....|....*....|..
gi 1056282013 254 IMLPLVLIYAIAQRSFVRGIAV 275
Cdd:pfam00528 162 ILLLLNLLVDILQRLLDPRVRK 183
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
14-268 6.24e-12

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 65.18  E-value: 6.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  14 RAVLVYTALIAIAWCWLFPIAWAVSGSLkregeitepkllpaHPRWSNYTEVFSLMPFARMFFNTVLYAGCVTAGQVFFC 93
Cdd:COG1178     9 PRLLLLLLALLLALLVLLPLLALLLRAF--------------TDGLANFWALLSDPYLWRALGNTLLLALLVTLLSLLLG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  94 SLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVI-----------PQFILMRTVGWVDTPWSMIVPGLFGSAFGTY--- 159
Cdd:COG1178    75 VPLAWLLARTDFPGRRLLRWLLLLPLALPPYVVALawialfgpnglLNTLLRALFGLEPPDIYGLGGIILVLVLFNYpyv 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 160 --LMRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMlqRNSLATLTLGLVRlr 237
Cdd:COG1178   155 ylLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVL--GGGYTTLTTAIYQ-- 230

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1056282013 238 gEYVARWPIIMAT--SMLIMLPLVLIYAIAQRS 268
Cdd:COG1178   231 -AWLGDFDLGAAAalALVLLLLVLLLLLLERRL 262
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 6-272 3.06e-11

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 62.47  E-value: 3.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013   6 RLFTRNVVRAVLVYTALIAIAWCWLFPIAWAVSGSLKREGEITEPKllpAHPRWSNYTEVFSLMPFARMFFNTVLYAGCV 85
Cdd:COG1176     3 AALRRRLRPLLLLLPALLWLLLFFVLPLLLLLVYSFTTRDPYGGVV---PGFTLENYARLFTDPLYLKVLLRTLWIALLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  86 TAGQVFFCSLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIP-QFILMRT---------VGWVDTPWSMIvPGLFGSA 155
Cdd:COG1176    80 TLICLLLGYPIAYFLARAPPRWRNLLLLLVILPFWTSFLVRTYAwIVLLGRNgllnslllaLGLIDEPLRLL-YTEFAVV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 156 FG-TYLMRQF--------FRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMLQRNsl 226
Cdd:COG1176   159 IGlVYVYLPFmvlplyaaLEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALLGGGK-- 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1056282013 227 aTLTLG-LVRLRGEYVARWPIIMATSMLIMLPLVLIYAIAQRSFVRG 272
Cdd:COG1176   237 -VLMIGnLIYQQFLSALNWPLAAALAVVLLLIVLLVLLLYLRLLRRR 282
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
2-268 1.05e-08

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 55.55  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013   2 ASAERLFTRNVVRAVLVYTALIAIAWCWLFPIAWAVSGSLKregeitepKLLPAHPRWSNYTEVFSLMPFARMFFNTVLY 81
Cdd:COG1178   275 ARRPRRVKLGRWRWLALALCLLLVLLGLLLPLLALLLWSLT--------KALDDNLTLDNYRFVLLDPSLLRALLNSLLL 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  82 AGCVTAGQVFFCSLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVGWVD---TPWSMIVPGLF-GSAFG 157
Cdd:COG1178   347 ALLAALLAVLLALLLAYLVRRRRGRLARLLDRLAMLPYAVPGIVLGLGLLLLFNRPLPLLlygTLAILVLAYVVrFLPFA 426

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 158 TYLMRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTWVNVWNDFlwPL-LMLQRNSLATLTLGLVRL 236
Cdd:COG1178   427 LRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKEL--SAtLLLRPPGFETLAVLIYQL 504

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1056282013 237 RGEYvaRWPIIMATSMLIML----PLVLIYAIAQRS 268
Cdd:COG1178   505 ASSG--RYGEAAALALLLVLvsllPVLLLERLLGRR 538
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 86-207 1.72e-07

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 51.29  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  86 TAGQVFFCSLAGYAFARLEFRGR---DTLFVLY--LGTLMVPLTVT-------VIPQFILMRTVGWVDTPWSMIVPGLF- 152
Cdd:COG0555    67 ALINLVFGLPLAWVLVRYRFPGKrlvDALVDLPfaLPTAVAGIALLllfgpngWLGQLLAPLGIKVAFTPLGIVLAQTFv 146

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1056282013 153 GSAFGTYLMRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTW 207
Cdd:COG0555   147 SLPFVVRTVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALLTGFALAF 201
Mo_ABC_porter TIGR01581
NifC-like ABC-type porter; This model describes a clade of ABC porter genes with relatively ...
 98-207 3.43e-04

NifC-like ABC-type porter; This model describes a clade of ABC porter genes with relatively weak homology compared to its neighbor clades, the molybdate (TIGR02141) and sulfate (TIGR00969) porters. Neighbor-Joining, PAM-distance phylogenetic trees support the separation of the clades in this way. Included in this group is a gene designated NifC in Clostridium pasturianum. It would be reasonable to presume that NifC acts as a molybdate porter since the most common form of nitrogenase is a molybdoenzyme. Several other sequences falling within the scope of this model are annotated as molybdate porters and one, from Halobacterium, is annotated as a sulfate porter. There is presently no experimental evidence to support annotations with this degree of specificity.


Pssm-ID: 130643  Cd Length: 225  Bit Score: 40.84  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  98 YAFARLEFRGRDTLFVLYLGTLMVPLTVT------------VIPQFILMRTVGWVDTPWSMIVPGLF-GSAFGTYLMRQF 164
Cdd:TIGR01581  46 YVLARVRFPLKKLLDTLLDLPMVLPPLVAglallllfgrngLLGPYLEAAGIQVIFSTLGVVLAQTFvASPYYVRVARST 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1056282013 165 FRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLTW 207
Cdd:TIGR01581 126 FKSVDPRYEDVARSLGAGPLETFRKITLPMARPGLLAGLVLAW 168
3a0106s02 TIGR00969
sulfate ABC transporter, permease protein; This model describes a subfamily of both CysT and ...
 168-206 1.33e-03

sulfate ABC transporter, permease protein; This model describes a subfamily of both CysT and CysW, paralogous and generally tandemly encoded permease proteins of the sulfate ABC transporter. [Transport and binding proteins, Anions]


Pssm-ID: 273370  Cd Length: 271  Bit Score: 39.26  E-value: 1.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1056282013 168 LPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLT 206
Cdd:TIGR00969 168 LGTEAEEAAATLGASGWQTFWRVTLPSIRWALLYGVVLT 206
COG4986 COG4986
ABC-type anion transport system, duplicated permease component [Inorganic ion transport and ...
 155-212 1.71e-03

ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism];


Pssm-ID: 444010 [Multi-domain]  Cd Length: 576  Bit Score: 39.44  E-value: 1.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1056282013 155 AFGTYlmrQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVmvlavltwvnVWN 212
Cdd:COG4986   149 AFSFY---QSLRTVPRDLDEAARIFRLSGWQRFWRLELPFAMPGL----------VWN 193
permease_CysW TIGR02140
sulfate ABC transporter, permease protein CysW; This model represents CysW, one of two ...
 78-206 2.43e-03

sulfate ABC transporter, permease protein CysW; This model represents CysW, one of two homologous, tandem permeases in the sulfate ABC transporter system; the other is CysT (TIGR02139). The sulfate transporter has been described in E. coli as transporting sulfate, thiosulfate, selenate, and selenite. Sulfate transporters may also transport molybdate ion if a specific molybdate transporter is not present. [Transport and binding proteins, Anions]


Pssm-ID: 162725  Cd Length: 261  Bit Score: 38.52  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013  78 TVLYAGCVTAGQVFFCSLAGYAFARLEFRGRDTLFVLYLGTLMVPLTVTVIPQFILMRTVGWVDtPWSMI--------VP 149
Cdd:TIGR02140  52 TLLVALIVVPLNTVFGVCAAWVLTRFQFPGKRLLLTIIDLPFSVSPVVAGLIFVLLYGSQGWLG-PWLEDldikiifsLP 130

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1056282013 150 GLF-GSAFGT--YLMRQF---FRTLPTDLEEAAILDGCSPWQIYWRILLPHARPAVMVLAVLT 206
Cdd:TIGR02140 131 GIVlATMFVTcpFVARELipvMEEQGTEQEEAALTLGASWWQTFWRVTLPNIKWGLLYGVILC 193
MetP COG2011
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ...
 119-198 4.21e-03

ABC-type methionine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 441614  Cd Length: 220  Bit Score: 37.73  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056282013 119 LMVPLTvtvipQFILMRTVGwvdtPWSMIVPGLFGSAFgtYLMRQF---FRTLPTDLEEAAILDGCSPWQIYWRILLPHA 195
Cdd:COG2011    77 ALIPLT-----RLIVGTSIG----TTAAIVPLTIAAIP--FFARLVenaLREVDPGVIEAAQAMGASPWQIIFKVLLPEA 145


                  ...
gi 1056282013 196 RPA 198
Cdd:COG2011   146 LPS 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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