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Conserved domains on  [gi|1055289855|ref|WP_066957173|]
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MULTISPECIES: isocitrate/isopropylmalate dehydrogenase family protein [Methanoculleus]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 10001441)

isocitrate/isopropylmalate dehydrogenase family protein similar to homoisocitrate dehydrogenase, which catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate

CATH:  3.40.718.10
EC:  1.1.1.-
Gene Ontology:  GO:0016616|GO:0046872|GO:0051287
PubMed:  10940051
SCOP:  4000791

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 1-317 4.33e-146

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


:

Pssm-ID: 440241  Cd Length: 346  Bit Score: 414.79  E-value: 4.33e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   1 MVKVAVVEGDGIGHEVIPVARDLLEAV----RPDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPDPE 76
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  77 ---YRSVLVQIRKALDLYANVRPIR-------------GEGVDVVIVRENTEGLYSGIEW-----TEPVRACTLRVVSRQ 135
Cdd:COG0473    81 gvrPESGLLALRKELDLYANLRPAKlypglpsplkpeiVEGIDLVIVRENTEGLYFGIGGrigtgTGEEVAIDTRVYTRK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 136 GSERIARYACTLAKSRR-HLTVGNKANVLK-SDCLFVDICTAEAVR-AGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMF 212
Cdd:COG0473   161 GIERIARYAFELARKRRkKVTSVDKANVLKlTSGLWREVVREVAKEyPDVELDHMYVDAAAMQLVRNPEQFDVIVTENLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 213 GDILSDAAAYLVGGLGMLPSANIGDRH-ALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVL 291
Cdd:COG0473   241 GDILSDLAAGLTGSLGLAPSANIGDEGkALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAVEKVL 320

                         330       340
                  ....*....|....*....|....*.
gi 1055289855 292 SAGIRTPDLGGDAGTREFGAAVLREV 317
Cdd:COG0473   321 AEGVRTPDLGGKAGTSEMGDAIIAAL 346
 
Name Accession Description Interval E-value
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 1-317 4.33e-146

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 414.79  E-value: 4.33e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   1 MVKVAVVEGDGIGHEVIPVARDLLEAV----RPDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPDPE 76
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  77 ---YRSVLVQIRKALDLYANVRPIR-------------GEGVDVVIVRENTEGLYSGIEW-----TEPVRACTLRVVSRQ 135
Cdd:COG0473    81 gvrPESGLLALRKELDLYANLRPAKlypglpsplkpeiVEGIDLVIVRENTEGLYFGIGGrigtgTGEEVAIDTRVYTRK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 136 GSERIARYACTLAKSRR-HLTVGNKANVLK-SDCLFVDICTAEAVR-AGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMF 212
Cdd:COG0473   161 GIERIARYAFELARKRRkKVTSVDKANVLKlTSGLWREVVREVAKEyPDVELDHMYVDAAAMQLVRNPEQFDVIVTENLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 213 GDILSDAAAYLVGGLGMLPSANIGDRH-ALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVL 291
Cdd:COG0473   241 GDILSDLAAGLTGSLGLAPSANIGDEGkALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAVEKVL 320

                         330       340
                  ....*....|....*....|....*.
gi 1055289855 292 SAGIRTPDLGGDAGTREFGAAVLREV 317
Cdd:COG0473   321 AEGVRTPDLGGKAGTSEMGDAIIAAL 346
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 4-314 1.08e-133

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 382.57  E-value: 1.08e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   4 VAVVEGDGIGHEVIPVARDLLEAVRPDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPDPEYRSVLVQ 83
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNKLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPANPGYKSVIVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  84 IRKALDLYANVRPIR---------GEGVDVVIVRENTEGLYSGIEWTEPVRACTLRVVSRQGSERIARYACTLAKSR-RH 153
Cdd:TIGR02088  81 LRKELDLYANVRPAKslpgipdlyPNGKDIVIVRENTEGLYAGFEFGFSDRAIAIRVITREGSERIARFAFNLAKERnRK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 154 LTVGNKANVLKSDC-LFVDICTAEAVRAGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMFGDILSDAAAYLVGGLGMLPS 232
Cdd:TIGR02088 161 VTCVHKANVLKGTDgLFREVCREIAKRYGVEYRDMYVDSAAMNLVKDPWRFDVIVTTNMFGDILSDLASALAGSLGLAPS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 233 ANIGDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVLSAGIRTPDLGGDAGTREFGAA 312
Cdd:TIGR02088 241 ANIGDRKALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKLVWEAVEYYIIEGKKTPDLGGTAKTKEVGDE 320


                  ..
gi 1055289855 313 VL 314
Cdd:TIGR02088 321 IA 322
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 1-317 1.01e-111

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 327.09  E-value: 1.01e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   1 MVKVAVVEGDGIGHEVIPVARDLLEAVRPDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPdpeyRSV 80
Cdd:PRK14025    1 MHKICVIEGDGIGKEVVPAALHVLEATGLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAGETA----ADV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  81 LVQIRKALDLYANVRPIRG--------EGVDVVIVRENTEGLYSGIE-WTEPVRACTLRVVSRQGSERIARYACTLAKSR 151
Cdd:PRK14025   77 IVKLRRILDTYANVRPVKSykgvkclyPDIDYVIVRENTEGLYKGIEaEIADGVTVATRVITRKASERIFRFAFEMAKRR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 152 RH------LTVGNKANVLK-SDCLFVDICTAEAVR-AGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMFGDILSDAAAYL 223
Cdd:PRK14025  157 KKmgkegkVTCAHKANVLKkTDGLFKKTFYEVAKEyPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 224 VGGLGMLPSANIGDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVLSAGIRTPDLGGD 303
Cdd:PRK14025  237 VGGLGLAPSANIGDKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGLTTPDLGGN 316

                         330
                  ....*....|....
gi 1055289855 304 AGTREFGAAVLREV 317
Cdd:PRK14025  317 LSTMEMAEEVAKRV 330
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
1-317 3.35e-110

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 323.61  E-value: 3.35e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   1 MVKVAVVEGDGIGHEVIPVARDLLEAVRPDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPDPeyRSV 80
Cdd:NF040626    1 MYKITVIPGDGIGKEVMEAALYVLDALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTPGQ--KSP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  81 LVQIRKALDLYANVRPIRG--------EGVDVVIVRENTEGLYSG-IEWTEPVRACTLRVVSRQGSERIARYACTLAKSR 151
Cdd:NF040626   79 IITLRKELDLYANLRPIKSyeginclfKDLDFLIVRENTEGLYSGlEEEYTEEKAIAERVITRKASERICKFAFEYAIKL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 152 RH--LTVGNKANVLK-SDCLFVDicTAEAVRAGVP-CRTS--YIDALCLDLLMHPDRYDVIVTTNMFGDILSDAAAYLVG 225
Cdd:NF040626  159 GRkkVTAVHKANVLKkTDGIFKD--TFYKVAKDYPqIETEdyYVDATAMYLITKPQDFDVIVTTNLFGDILSDEAAGLVG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 226 GLGMLPSANIGDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVLSAG-IRTPDLGGDA 304
Cdd:NF040626  237 GLGLAPSANIGDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEKVLREGkVVTPDLGGNA 316

                         330
                  ....*....|...
gi 1055289855 305 GTREFGAAVLREV 317
Cdd:NF040626  317 KTMEMANEIKKKI 329
AksF_Meth NF040619
homoisocitrate dehydrogenase;
1-310 2.90e-105

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 310.92  E-value: 2.90e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   1 MVKVAVVEGDGIGHEVIPVARDLLEAVRpDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPDPE---- 76
Cdd:NF040619    1 MPKICVIEGDGIGKEVIPETVRVLKELG-DFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTElknk 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  77 -YRSVLVQIRKALDLYANVRPI-------RGEGVDVVIVRENTEGLYSGIEWTEPVR--ACTLRVVSRQGSERIARYACT 146
Cdd:NF040619   80 nYKSPILTLRKELDLYANVRPInnfgdgqDVKNIDFVIIRENTEGLYVGREYYDEENeiAIAERIISKKGSERIIKFAFE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 147 LAK--SRRHLTVGNKANVLK-SDCLFVDI---CTAEAVRAGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMFGDILSDAA 220
Cdd:NF040619  160 YAKknNRKKVSCIHKANVLRvTDGLFLEIfneIKKKYKNFNIEADDYLVDATAMYLIKNPEMFDVIVTTNLFGDILSDEA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 221 AYLVGGLGMLPSANIGDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVLSAGIRTPDL 300
Cdd:NF040619  240 SGLIGGLGLAPSANIGDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLIREAVKKCLENGKVTPDL 319

                         330
                  ....*....|
gi 1055289855 301 GGDAGTREFG 310
Cdd:NF040619  320 GGNLKTKEVT 329
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
3-313 1.28e-101

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 301.91  E-value: 1.28e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   3 KVAVVEGDGIGHEVIPVARDLLEAVRP----DLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTP--PDPE 76
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEkaplEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPkwDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  77 YRS--VLVQIRKALDLYANVRPIR--------------GEGVDVVIVRENTEGLYSGIEWT----EPVRACTLRVVSRQG 136
Cdd:pfam00180  81 VRPenGLLALRKELGLFANLRPAKvfpplgdasplkneVEGVDIVIVRELTGGIYFGIEKGikgsGNEVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 137 SERIARYACTLA--KSRRHLTVGNKANVLKSDCLFVDICTAEAVR--AGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMF 212
Cdd:pfam00180 161 IERIARVAFELArkRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAeyPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 213 GDILSDAAAYLVGGLGMLPSANIG-DRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAH-LGDPASAAAMEAAVGRV 290
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGaNGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKV 320

                         330       340
                  ....*....|....*....|....*.
gi 1055289855 291 LSAGIRTPDLGGDA---GTREFGAAV 313
Cdd:pfam00180 321 LESGIRTGDLAGSAtyvSTSEFGEAV 346
 
Name Accession Description Interval E-value
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 1-317 4.33e-146

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 414.79  E-value: 4.33e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   1 MVKVAVVEGDGIGHEVIPVARDLLEAV----RPDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPDPE 76
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  77 ---YRSVLVQIRKALDLYANVRPIR-------------GEGVDVVIVRENTEGLYSGIEW-----TEPVRACTLRVVSRQ 135
Cdd:COG0473    81 gvrPESGLLALRKELDLYANLRPAKlypglpsplkpeiVEGIDLVIVRENTEGLYFGIGGrigtgTGEEVAIDTRVYTRK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 136 GSERIARYACTLAKSRR-HLTVGNKANVLK-SDCLFVDICTAEAVR-AGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMF 212
Cdd:COG0473   161 GIERIARYAFELARKRRkKVTSVDKANVLKlTSGLWREVVREVAKEyPDVELDHMYVDAAAMQLVRNPEQFDVIVTENLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 213 GDILSDAAAYLVGGLGMLPSANIGDRH-ALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVL 291
Cdd:COG0473   241 GDILSDLAAGLTGSLGLAPSANIGDEGkALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAVEKVL 320

                         330       340
                  ....*....|....*....|....*.
gi 1055289855 292 SAGIRTPDLGGDAGTREFGAAVLREV 317
Cdd:COG0473   321 AEGVRTPDLGGKAGTSEMGDAIIAAL 346
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 4-314 1.08e-133

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 382.57  E-value: 1.08e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   4 VAVVEGDGIGHEVIPVARDLLEAVRPDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPDPEYRSVLVQ 83
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNKLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPANPGYKSVIVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  84 IRKALDLYANVRPIR---------GEGVDVVIVRENTEGLYSGIEWTEPVRACTLRVVSRQGSERIARYACTLAKSR-RH 153
Cdd:TIGR02088  81 LRKELDLYANVRPAKslpgipdlyPNGKDIVIVRENTEGLYAGFEFGFSDRAIAIRVITREGSERIARFAFNLAKERnRK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 154 LTVGNKANVLKSDC-LFVDICTAEAVRAGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMFGDILSDAAAYLVGGLGMLPS 232
Cdd:TIGR02088 161 VTCVHKANVLKGTDgLFREVCREIAKRYGVEYRDMYVDSAAMNLVKDPWRFDVIVTTNMFGDILSDLASALAGSLGLAPS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 233 ANIGDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVLSAGIRTPDLGGDAGTREFGAA 312
Cdd:TIGR02088 241 ANIGDRKALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKLVWEAVEYYIIEGKKTPDLGGTAKTKEVGDE 320


                  ..
gi 1055289855 313 VL 314
Cdd:TIGR02088 321 IA 322
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 1-317 1.01e-111

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 327.09  E-value: 1.01e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   1 MVKVAVVEGDGIGHEVIPVARDLLEAVRPDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPdpeyRSV 80
Cdd:PRK14025    1 MHKICVIEGDGIGKEVVPAALHVLEATGLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAGETA----ADV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  81 LVQIRKALDLYANVRPIRG--------EGVDVVIVRENTEGLYSGIE-WTEPVRACTLRVVSRQGSERIARYACTLAKSR 151
Cdd:PRK14025   77 IVKLRRILDTYANVRPVKSykgvkclyPDIDYVIVRENTEGLYKGIEaEIADGVTVATRVITRKASERIFRFAFEMAKRR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 152 RH------LTVGNKANVLK-SDCLFVDICTAEAVR-AGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMFGDILSDAAAYL 223
Cdd:PRK14025  157 KKmgkegkVTCAHKANVLKkTDGLFKKTFYEVAKEyPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 224 VGGLGMLPSANIGDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVLSAGIRTPDLGGD 303
Cdd:PRK14025  237 VGGLGLAPSANIGDKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGLTTPDLGGN 316

                         330
                  ....*....|....
gi 1055289855 304 AGTREFGAAVLREV 317
Cdd:PRK14025  317 LSTMEMAEEVAKRV 330
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
1-317 3.35e-110

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 323.61  E-value: 3.35e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   1 MVKVAVVEGDGIGHEVIPVARDLLEAVRPDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPDPeyRSV 80
Cdd:NF040626    1 MYKITVIPGDGIGKEVMEAALYVLDALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTPGQ--KSP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  81 LVQIRKALDLYANVRPIRG--------EGVDVVIVRENTEGLYSG-IEWTEPVRACTLRVVSRQGSERIARYACTLAKSR 151
Cdd:NF040626   79 IITLRKELDLYANLRPIKSyeginclfKDLDFLIVRENTEGLYSGlEEEYTEEKAIAERVITRKASERICKFAFEYAIKL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 152 RH--LTVGNKANVLK-SDCLFVDicTAEAVRAGVP-CRTS--YIDALCLDLLMHPDRYDVIVTTNMFGDILSDAAAYLVG 225
Cdd:NF040626  159 GRkkVTAVHKANVLKkTDGIFKD--TFYKVAKDYPqIETEdyYVDATAMYLITKPQDFDVIVTTNLFGDILSDEAAGLVG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 226 GLGMLPSANIGDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVLSAG-IRTPDLGGDA 304
Cdd:NF040626  237 GLGLAPSANIGDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEKVLREGkVVTPDLGGNA 316

                         330
                  ....*....|...
gi 1055289855 305 GTREFGAAVLREV 317
Cdd:NF040626  317 KTMEMANEIKKKI 329
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-320 1.58e-105

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 312.42  E-value: 1.58e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   1 MVKVAVVEGDGIGHEVIPVARDLLEAVR----PDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTP---- 72
Cdd:PRK00772    2 TYKIAVLPGDGIGPEVMAEAVKVLDAVAekfgFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPkwdn 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  73 PDPEYRSV--LVQIRKALDLYANVRPIR---------------GEGVDVVIVRENTEGLYSG-----IEWTEPVRACTLR 130
Cdd:PRK00772   82 LPPDVRPErgLLALRKELGLFANLRPAKlypgladasplkpeiVAGLDILIVRELTGGIYFGeprgrEGLGGEERAFDTM 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 131 VVSRQGSERIARYACTLAKSRR-HLTVGNKANVLKSDCLFVDICTAEAVR-AGVPCRTSYIDALCLDLLMHPDRYDVIVT 208
Cdd:PRK00772  162 VYTREEIERIARVAFELARKRRkKVTSVDKANVLESSRLWREVVTEVAKEyPDVELSHMYVDNAAMQLVRNPKQFDVIVT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 209 TNMFGDILSDAAAYLVGGLGMLPSANIG-DRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAH-LGDPASAAAMEAA 286
Cdd:PRK00772  242 ENLFGDILSDEAAMLTGSLGMLPSASLGeSGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEEAADAIEAA 321

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1055289855 287 VGRVLSAGIRTPDL---GGDAGTREFGAAVLREVGRG 320
Cdd:PRK00772  322 VEKVLAQGYRTADIaegGGKVSTSEMGDAILAALAEG 358
AksF_Meth NF040619
homoisocitrate dehydrogenase;
1-310 2.90e-105

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 310.92  E-value: 2.90e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   1 MVKVAVVEGDGIGHEVIPVARDLLEAVRpDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPDPE---- 76
Cdd:NF040619    1 MPKICVIEGDGIGKEVIPETVRVLKELG-DFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTElknk 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  77 -YRSVLVQIRKALDLYANVRPI-------RGEGVDVVIVRENTEGLYSGIEWTEPVR--ACTLRVVSRQGSERIARYACT 146
Cdd:NF040619   80 nYKSPILTLRKELDLYANVRPInnfgdgqDVKNIDFVIIRENTEGLYVGREYYDEENeiAIAERIISKKGSERIIKFAFE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 147 LAK--SRRHLTVGNKANVLK-SDCLFVDI---CTAEAVRAGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMFGDILSDAA 220
Cdd:NF040619  160 YAKknNRKKVSCIHKANVLRvTDGLFLEIfneIKKKYKNFNIEADDYLVDATAMYLIKNPEMFDVIVTTNLFGDILSDEA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 221 AYLVGGLGMLPSANIGDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVLSAGIRTPDL 300
Cdd:NF040619  240 SGLIGGLGLAPSANIGDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLIREAVKKCLENGKVTPDL 319

                         330
                  ....*....|
gi 1055289855 301 GGDAGTREFG 310
Cdd:NF040619  320 GGNLKTKEVT 329
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
3-313 1.28e-101

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 301.91  E-value: 1.28e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   3 KVAVVEGDGIGHEVIPVARDLLEAVRP----DLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTP--PDPE 76
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEkaplEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPkwDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  77 YRS--VLVQIRKALDLYANVRPIR--------------GEGVDVVIVRENTEGLYSGIEWT----EPVRACTLRVVSRQG 136
Cdd:pfam00180  81 VRPenGLLALRKELGLFANLRPAKvfpplgdasplkneVEGVDIVIVRELTGGIYFGIEKGikgsGNEVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 137 SERIARYACTLA--KSRRHLTVGNKANVLKSDCLFVDICTAEAVR--AGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMF 212
Cdd:pfam00180 161 IERIARVAFELArkRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAeyPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 213 GDILSDAAAYLVGGLGMLPSANIG-DRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAH-LGDPASAAAMEAAVGRV 290
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGaNGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKV 320

                         330       340
                  ....*....|....*....|....*.
gi 1055289855 291 LSAGIRTPDLGGDA---GTREFGAAV 313
Cdd:pfam00180 321 LESGIRTGDLAGSAtyvSTSEFGEAV 346
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 3-315 9.91e-89

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 268.90  E-value: 9.91e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   3 KVAVVEGDGIGHEVIPVARDLLEAVRPDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPDPEYRSVLV 82
Cdd:PRK08997    4 TITVIPGDGIGPSIIDATLKILDKLGCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGEGFTSINV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  83 QIRKALDLYANVRPI--------RGEGVDVVIVRENTEGLYSGIEWT---EPVRACTLRVVSRQGSERIARYACTLAKS- 150
Cdd:PRK08997   84 TLRKKFDLYANVRPVlsfpgtkaRYDNIDIITVRENTEGMYSGEGQTvseDGETAEATSIITRKGAERIVRFAYELARKe 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 151 -RRHLTVGNKANVLKSDC-LFVDIctAEAVRAGVPCRTS---YIDALCLDLLMHPDRYDVIVTTNMFGDILSDAAAYLVG 225
Cdd:PRK08997  164 gRKKVTAVHKANIMKSTSgLFLKV--AREVALRYPDIEFeemIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 226 GLGMLPSANIGDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVLSAGIR-TPDLGGDA 304
Cdd:PRK08997  242 GLGMAPGANIGRDAAIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRtTRDLGGTH 321

                         330
                  ....*....|.
gi 1055289855 305 GTREFGAAVLR 315
Cdd:PRK08997  322 GTTDFTQAVID 332
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 3-314 7.63e-85

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 259.38  E-value: 7.63e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   3 KVAVVEGDGIGHEVIPVARDLLEAVRP-----DLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPD-PE 76
Cdd:TIGR02089   5 RIAAIPGDGIGKEVVAAALQVLEAAAKrhggfSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPALvPD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  77 YRSV---LVQIRKALDLYANVRPIR------------GEG-VDVVIVRENTEGLYSGI-----EWTEPVRACTLRVVSRQ 135
Cdd:TIGR02089  85 HISLwglLLKIRREFDQYANVRPAKllpgvtsplrncGPGdFDFVVVRENSEGEYSGVggrihRGTDEEVATQNAIFTRK 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 136 GSERIARYACTLAKSRR-HLTVGNKANVLKSDCLFVDICTAEAVR--AGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMF 212
Cdd:TIGR02089 165 GVERIMRFAFELAQKRRkHLTSATKSNGIRHSMPFWDEVFAEVAAeyPDVEWDSYHIDALAARFVLKPETFDVIVASNLF 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 213 GDILSDAAAYLVGGLGMLPSANI---GDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGR 289
Cdd:TIGR02089 245 GDILSDLGAALMGSLGVAPSANInpeGKFPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGAKIMDAIER 324

                         330       340
                  ....*....|....*....|....*
gi 1055289855 290 VLSAGIRTPDLGGDAGTREFGAAVL 314
Cdd:TIGR02089 325 VTAAGILTPDVGGKATTSEVTEAVC 349
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 3-317 6.71e-83

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 254.25  E-value: 6.71e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   3 KVAVVEGDGIGHEVIPVARDLLEAVRP----DLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAI------TTP 72
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAErfglKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVggpkwdNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  73 PDPEYRSVLVQIRKALDLYANVRPIR---------------GEGVDVVIVRENTEGLYSG--IEWTEPVRACTLRVVSRQ 135
Cdd:TIGR00169  81 RDQRPEQGLLKLRKSLDLFANLRPAKvfpgledlsplkeeiAKGVDFVVVRELTGGIYFGepKGREGEGEAWDTEVYTVP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 136 GSERIARYACTLA-KSRRHLTVGNKANVLKSDCLFVDicTAEAVRAGVPCRT---SYIDALCLDLLMHPDRYDVIVTTNM 211
Cdd:TIGR00169 161 EIERIARVAFEMArKRRKKVTSVDKANVLESSRLWRK--TVEEIAKEYPDVElehQYIDNAAMQLVKSPTQFDVVVTSNL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 212 FGDILSDAAAYLVGGLGMLPSANIG-DRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAH-LGDPASAAAMEAAVGR 289
Cdd:TIGR00169 239 FGDILSDEASVITGSLGMLPSASLGsDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYsFNLEEAADAIEAAVKK 318

                         330       340
                  ....*....|....*....|....*...
gi 1055289855 290 VLSAGIRTPDLGGDAGTREFGAAVLREV 317
Cdd:TIGR00169 319 VLAEGYRTPDLGSSATTAVGTAEMGEEL 346
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-319 6.54e-82

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 255.97  E-value: 6.54e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   1 MVKVAVVEGDGIGHEVIPVARDLLEAVRPDLEFFDVEVGYGRWERTGSA-CDEETIADLRSADAILFGAITTPPDPEYRS 79
Cdd:PRK09222    4 KTPITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEIGEKVYKKGWTSgISPSAWESIRRTKVLLKAPITTPQGGGYKS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  80 VLVQIRKALDLYANVRPIRG---------EGVDVVIVRENTEGLYSGIEW--TEPVRACtLRVVSRQGSERIARYACTLA 148
Cdd:PRK09222   84 LNVTLRKTLGLYANVRPCVSyhpfvetkhPNLDVVIIRENEEDLYAGIEHrqTPDVYQC-LKLISRPGSEKIIRYAFEYA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 149 KS--RRHLTVGNKANVLK-SDCLF--------------------VDICTAEavragvpcrtsyidalcldLLMHPDRYDV 205
Cdd:PRK09222  163 RAngRKKVTCLTKDNIMKlTDGLFhkvfdeiakeypdieaehyiVDIGAAR-------------------LATNPENFDV 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 206 IVTTNMFGDILSDAAAYLVGGLGMLPSANIGDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEA 285
Cdd:PRK09222  224 IVTPNLYGDILSDIAAEISGSVGLAGSANIGEEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIEN 303

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1055289855 286 AVGRVLSAGIRTPDLGGD------AGTREFGAAVLREVGR 319
Cdd:PRK09222  304 AWLKTLEDGIHTADIYNEgvskkkVGTKEFAEAVIENLGQ 343
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 1-317 1.66e-75

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 235.21  E-value: 1.66e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   1 MVKVAVVEGDGIGHEVIPVARDLLEAV---RPDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAI---TTPPD 74
Cdd:PRK03437    4 TMKLAVIPGDGIGPEVVAEALKVLDAVaagGPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIgdpSVPSG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  75 PEYRSVLVQIRKALDLYANVRPIR-----------GEGVDVVIVRENTEGLYSGI-----EWTEPVRACTLRVVSRQGSE 138
Cdd:PRK03437   84 VLERGLLLKLRFALDHYVNLRPSKlypgvtsplagPGDIDFVVVREGTEGPYTGNggalrVGTPHEVATEVSVNTAFGVE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 139 RIARYACTLAKSR--RHLTVGNKANVL-KSDCLFVDicTAEAVRAGVP-CRTSY--IDALCLDLLMHPDRYDVIVTTNMF 212
Cdd:PRK03437  164 RVVRDAFERAQKRprKHLTLVHKTNVLtFAGDLWQR--TVDEVAAEYPdVTVDYqhVDAATIFMVTDPSRFDVIVTDNLF 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 213 GDILSDAAAYLVGGLGMLPSANI---GDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGR 289
Cdd:PRK03437  242 GDIITDLAAAVTGGIGLAASGNInptGTNPSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDHLGEEDAAARIEAAVEA 321

                         330       340
                  ....*....|....*....|....*...
gi 1055289855 290 VLSAgirtpDLGGDAGTREFGAAVLREV 317
Cdd:PRK03437  322 DLAE-----RGKMGRSTAEVGDRIAARL 344
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 1-317 5.29e-74

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 231.53  E-value: 5.29e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   1 MVKVAVVEGDGIGHEVIPVARDLLEAVRP-----DLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPD- 74
Cdd:PRK08194    3 QFKIAVIPGDGVGKEVVPAAVRVLKAVAEvhgglKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPKLv 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  75 PEYRSV---LVQIRKALDLYANVRP---IRG--------EGVDVVIVRENTEGLYSG----IEWTEPVRACTLRVVSRQG 136
Cdd:PRK08194   83 PDHISLwglLIKIRREFEQVINIRPakqLRGiksplanpKDFDLLVVRENSEGEYSEvggrIHRGEDEIAIQNAVFTRKG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 137 SERIARYACTLAKSRR-HLTVGNKANVLKSDCLFVDICTAEAVR--AGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMFG 213
Cdd:PRK08194  163 TERAMRYAFELAAKRRkHVTSATKSNGIVHSMPFWDEVFQEVGKdyPEIETDSQHIDALAAFFVTRPEEFDVIVASNLFG 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 214 DILSDAAAYLVGGLGMLPSANI---GDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRV 290
Cdd:PRK08194  243 DILTDIGAAIMGSIGIAPAANInvnGKYPSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDHFGEEELGSHLLDVIEDV 322

                         330       340
                  ....*....|....*....|....*..
gi 1055289855 291 LSAGIRTPDLGGDAGTREFGAAVLREV 317
Cdd:PRK08194  323 TEDGIKTPDIGGRATTDEVTDEIISRL 349
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 9-313 9.25e-66

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 211.28  E-value: 9.25e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   9 GDGIGHEVIPVARDLLEAVRPDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPDPEYRSVLVQIRKAL 88
Cdd:PLN00118   49 GDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTTVDPRTGSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLNLTLRKEL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  89 DLYANVRP--------IRGEGVDVVIVRENTEGLYSGIEwTEPVRAC--TLRVVSRQGSERIARYACTLAKS--RRHLTV 156
Cdd:PLN00118  129 GLYANVRPcyslpgykTRYDDVDLVTIRENTEGEYSGLE-HQVVRGVveSLKIITRQASLRVAEYAFHYAKThgRKRVSA 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 157 GNKANVL-KSDCLFVDICTAEAVRAG-VPCRTSYIDALCLDLLMHPDRYDVIVTTNMFGDILSDAAAYLVGGLGMLPSAN 234
Cdd:PLN00118  208 IHKANIMkKTDGLFLKCCREVAEKYPeIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCN 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 235 IGDRH-ALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVLSAG-IRTPDLGGDAGTREFGAA 312
Cdd:PLN00118  288 IGENGlALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTIAEGkYRTADLGGSSTTTDFTKA 367


                  .
gi 1055289855 313 V 313
Cdd:PLN00118  368 I 368
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 4-315 3.37e-58

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 191.23  E-value: 3.37e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   4 VAVVEGDGIGHEVIPVARDLLEAVRPDLEFFDVEVgYGRWERTgsacDEETIADLRSADAILFGAITTPPDPEYRSVLVQ 83
Cdd:PLN00123   33 VTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEV-HGDMKKV----PEEVLESIRRNKVCLKGGLATPVGGGVSSLNVQ 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  84 IRKALDLYANV--------RPIRGEGVDVVIVRENTEGLYSGIEwTEPVRAC--TLRVVSRQGSERIARYACTLA--KSR 151
Cdd:PLN00123  108 LRKELDLFASLvncfnlpgLPTRHENVDIVVIRENTEGEYSGLE-HEVVPGVveSLKVITKFCSERIAKYAFEYAylNNR 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 152 RHLTVGNKANVLK-SDCLFVDICTAEAVR-AGVPCRTSYIDALCLDLLMHPDRYDVIVTTNMFGDILSDAAAYLVGGLGM 229
Cdd:PLN00123  187 KKVTAVHKANIMKlADGLFLESCREVAKKyPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTGV 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 230 LPSANIGDRHALFEPVHGSA----PDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVLSAG-IRTPDLGGDA 304
Cdd:PLN00123  267 MPGGNVGADHAVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGkYRTKDLGGSS 346

                         330
                  ....*....|.
gi 1055289855 305 GTREFGAAVLR 315
Cdd:PLN00123  347 TTQEVVDAVIA 357
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 7-313 1.31e-56

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 188.40  E-value: 1.31e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   7 VEGDGIGHEVIPVARDLLEAvrpdleffDVEVGYG-----RWE----------RTGSACDEETiadlrsADAI------L 65
Cdd:COG0538    24 IEGDGIGPEITRAIWKVIDA--------AVEKAYGgkrdiEWKevdagekardETGDWLPDET------AEAIkeygvgI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  66 FGAITTPPDPEYRSVLVQIRKALDLYANVRPIR---G--------EGVDVVIVRENTEGLYSGIEWTEP------VRAcT 128
Cdd:COG0538    90 KGPLTTPVGGGWRSLNVTIRQILDLYVCRRPVRyfkGvpspvkhpEKVDIVIFRENTEDIYAGIEWKAGspealkLIF-F 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 129 LR-------------------VVSRQGSERIAR----YActLAKSRRHLTVGNKANVLK-SDCLFVDICTAEA------- 177
Cdd:COG0538   169 LEdemgvtvirfpedsgigikPVSDEGTERLVRaaiqYA--LDNKRKSVTLVHKGNIMKfTEGAFKDWGYEVAeeefgdk 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 178 -VRAGVPCRTSY-------------IDALCLDLLMHPDRYDVIVTTNMFGDILSDAAAYLVGGLGMLPSANIGDR-HALF 242
Cdd:COG0538   247 fITEGPWEKYKGpkpagkivykdriADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDgGAEF 326

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1055289855 243 EPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLGDPASAAAMEAAVGRVLSAGIRTPDLG---GDA---GTREFGAAV 313
Cdd:COG0538   327 EATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKVTYDLArlmEGAtelSTSEFGDAI 403
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
7-314 3.08e-53

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 179.64  E-value: 3.08e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   7 VEGDGIGHEVIPVARDLLEAV-------RPDLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAITTPPDPEYRS 79
Cdd:PRK06451   29 VEGDGIGPEITHAAMKVINKAvekaygsDREIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPIGKGWKS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  80 VLVQIRKALDLYANVRPIR-----------GEGVDVVIVRENTEGLYSGIEWT---------------------EPVRAC 127
Cdd:PRK06451  109 INVAIRLMLDLYANIRPVKyipgiesplknPEKIDLIIFRENTDDLYRGIEYPydseeakkirdflrkelgvevEDDTGI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 128 TLRVVSRQGSERIARYACTLA--KSRRHLTVGNKANVLK-SDCLFVD-------------ICTAEAV---RAGVPCRTSY 188
Cdd:PRK06451  189 GIKLISKFKTQRIARMAIKYAidHKRKKVTIMHKGNVMKyTEGAFREwayevalkefrdyVVTEEEVtknYNGVPPSGKV 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 189 I------DALCLDLLMHPDRYDVIVTTNMFGDILSDAAAYLVGGLGMLPSANIGDRHALFEPVHGSAPDIAGRNIANPVA 262
Cdd:PRK06451  269 IindriaDNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFEAIHGTAPKYAGKNVANPTG 348

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1055289855 263 AIRSAAMLLAHLGDPASAAAMEAAVGRVLSAGIRTPDL----GGDA-GTREFGAAVL 314
Cdd:PRK06451  349 IIKGGELMLRFMGWDKAADLIDKAIMESIKQKKVTQDLarfmGVRAlSTTEYTDELI 405
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 4-317 1.60e-47

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 164.86  E-value: 1.60e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   4 VAVVEGDGIGHEVIPVARDLLEAVRP----DLEFFDVEVGYGRWERTGSACDEETIADLRSADAILFGAI--------TT 71
Cdd:PLN02329   49 IALLPGDGIGPEVISVAKNVLQKAGSleglEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIggykwdknEK 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  72 PPDPEYrsVLVQIRKALDLYANVRPIR---------------GEGVDVVIVRENTEGLYSGiewtEPvRACTL------- 129
Cdd:PLN02329  129 HLRPEM--ALFYLRRDLKVFANLRPATvlpqlvdastlkkevAEGVDMMIVRELTGGIYFG----EP-RGITInengeev 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 130 ----RVVSRQGSERIARYACTLAKSRR-HLTVGNKANVLKSDCLFVDICTAEAVR-AGVPCRTSYIDALCLDLLMHPDRY 203
Cdd:PLN02329  202 gvstEIYAAHEIDRIARVAFETARKRRgKLCSVDKANVLDASILWRKRVTALASEyPDVELSHMYVDNAAMQLIRDPKQF 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 204 DVIVTTNMFGDILSDAAAYLVGGLGMLPSANIGDRH-ALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAH-LGDPASAA 281
Cdd:PLN02329  282 DTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAK 361

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1055289855 282 AMEAAVGRVLSAGIRTPDLGGDA----GTREFGAAVLREV 317
Cdd:PLN02329  362 RIEDAVVDALNKGFRTGDIYSPGnklvGCKEMGEEVLKSV 401
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 7-275 1.17e-46

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 162.54  E-value: 1.17e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   7 VEGDGIGHEVIPVARDLLEAV-------RPDLEFFDVEVGYGRWERTGSAC--DEETIADLRSADAILFGAITTPPDPEY 77
Cdd:PRK07006   25 IEGDGIGPDITPAMLKVVDAAvekaykgERKISWMEIYAGEKATKVYGEDVwlPEETLDLIREYRVAIKGPLTTPVGGGI 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  78 RSVLVQIRKALDLYANVRPIR-----------GEGVDVVIVRENTEGLYSGIEW---TEPVR------------------ 125
Cdd:PRK07006  105 RSLNVALRQELDLYVCLRPVRyfkgvpspvkrPEDTDMVIFRENSEDIYAGIEWkagSAEAKkvikflqeemgvkkirfp 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 126 -ACTLRV--VSRQGSERIARYAC--TLAKSRRHLTVGNKANVLK------------------SDCLF-----VDICTAEA 177
Cdd:PRK07006  185 eTSGIGIkpVSEEGTERLVRAAIeyAIDNDRKSVTLVHKGNIMKftegafkdwgyqlaeeefGDELIdggpwDKIKNPET 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 178 VRAGVpCRTSYIDALCLDLLMHPDRYDVIVTTNMFGDILSDAAAYLVGGLGMLPSANIGDRHALFEPVHGSAPDIAGRNI 257
Cdd:PRK07006  265 GKEII-VKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANINDGHAIFEATHGTAPKYAGLDK 343

                         330
                  ....*....|....*...
gi 1055289855 258 ANPVAAIRSAAMLLAHLG 275
Cdd:PRK07006  344 VNPGSVILSAEMMLRHMG 361
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
7-275 7.07e-36

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 134.84  E-value: 7.07e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855   7 VEGDGIGHEVIPVARDLLEAV-------RPDLEFFDVEVGygrwertGSACD---------EETIADLRSADAILFGAIT 70
Cdd:PRK07362   34 IRGDGTGVDIWPATQKVLDAAvakayggERKINWFKVYAG-------DEACDlygtyqylpEDTLEAIREYGVAIKGPLT 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855  71 TPPDPEYRSVLVQIRKALDLYANVRPIR-----------GEGVDVVIVRENTEGLYSGIEWTEPVRACT----------- 128
Cdd:PRK07362  107 TPIGGGIRSLNVALRQIFDLYSCVRPCRyyagtpsphknPEKLDVIVYRENTEDIYMGIEWEAGDEIGDklikhlneevi 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 129 ------------------LRVVSRQGSERIAR----YACTLAKSRRHLTVGNKANVLK-SDCLFVD----ICTAEAVRAG 181
Cdd:PRK07362  187 paspelgkrqiplgsgigIKPVSKTGSQRHIRraieHALRLPGDKRHVTLVHKGNIMKyTEGAFRDwgyeLATTEFRDEC 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055289855 182 VPCRTSYI-----------------------DALCL---------------------------DLLM------------- 198
Cdd:PRK07362  267 VTERESWIlsnkeknpnisiednarmiepgyDSLTPekkaaicaevkevldsiwsshgngkwkEKVLvddriadsifqqi 346

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1055289855 199 --HPDRYDVIVTTNMFGDILSDAAAYLVGGLGMLPSANIGDRHALFEPVHGSAPDIAGRNIANPVAAIRSAAMLLAHLG 275
Cdd:PRK07362  347 qtRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEYLG 425
PdxA COG1995
4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; ...
 244-273 2.73e-03

4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; 4-hydroxy-L-threonine phosphate dehydrogenase PdxA is part of the Pathway/BioSystem: Pyridoxal phosphate biosynthesis


Pssm-ID: 441598  Cd Length: 330  Bit Score: 38.89  E-value: 2.73e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1055289855 244 PVHGSAPDIAGRNIANP---VAAIRSAAMLLAH 273
Cdd:COG1995   296 VDHGTAFDIAGKGIADPgslIAAIRLAARLARN 328
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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