NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1021849228|ref|WP_063390984|]
View 

helix-turn-helix transcriptional regulator [Salmonella enterica]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10616232)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HTH_35 pfam13693
Winged helix-turn-helix DNA-binding;
5-70 1.65e-35

Winged helix-turn-helix DNA-binding;


:

Pssm-ID: 433408  Cd Length: 70  Bit Score: 114.25  E-value: 1.65e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1021849228  5 DWHSADIIAALKKRGTSLSAVSRNSGLASATLANALIRHWPKGERLIAEALGTAPEQIWPSRYRKP 70
Cdd:pfam13693  1 DWHPADIKAALRKRGTTLAALSRSAGLSSSTLSNALTRPWPKGERIIAEALGVPPEEIWPSRYFDD 66
 
Name Accession Description Interval E-value
HTH_35 pfam13693
Winged helix-turn-helix DNA-binding;
5-70 1.65e-35

Winged helix-turn-helix DNA-binding;


Pssm-ID: 433408  Cd Length: 70  Bit Score: 114.25  E-value: 1.65e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1021849228  5 DWHSADIIAALKKRGTSLSAVSRNSGLASATLANALIRHWPKGERLIAEALGTAPEQIWPSRYRKP 70
Cdd:pfam13693  1 DWHPADIKAALRKRGTTLAALSRSAGLSSSTLSNALTRPWPKGERIIAEALGVPPEEIWPSRYFDD 66
SfsB COG3423
Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];
3-68 2.00e-34

Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];


Pssm-ID: 442649 [Multi-domain]  Cd Length: 69  Bit Score: 111.46  E-value: 2.00e-34
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1021849228  3 QPDWHSADIIAALKKRGTSLSAVSRNSGLASATLANALIRHWPKGERLIAEALGTAPEQIWPSRYR 68
Cdd:COG3423    4 KKDWHPADIKAALRKRGTSLAALAREAGLSSSTLSNALTRPWPKGERAIAEALGVPPEEIWPSRYA 69
PRK10344 PRK10344
DNA-binding transcriptional regulator SfsB;
5-71 1.07e-30

DNA-binding transcriptional regulator SfsB;


Pssm-ID: 182394  Cd Length: 92  Bit Score: 103.12  E-value: 1.07e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1021849228  5 DWHSADIIAALKKRGTSLSAVSRNSGLASATLANALIRHWPKGERLIAEALGTAPEQIWPSRYRKPE 71
Cdd:PRK10344   7 DWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWVIWPSRYHDPQ 73
 
Name Accession Description Interval E-value
HTH_35 pfam13693
Winged helix-turn-helix DNA-binding;
5-70 1.65e-35

Winged helix-turn-helix DNA-binding;


Pssm-ID: 433408  Cd Length: 70  Bit Score: 114.25  E-value: 1.65e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1021849228  5 DWHSADIIAALKKRGTSLSAVSRNSGLASATLANALIRHWPKGERLIAEALGTAPEQIWPSRYRKP 70
Cdd:pfam13693  1 DWHPADIKAALRKRGTTLAALSRSAGLSSSTLSNALTRPWPKGERIIAEALGVPPEEIWPSRYFDD 66
SfsB COG3423
Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];
3-68 2.00e-34

Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];


Pssm-ID: 442649 [Multi-domain]  Cd Length: 69  Bit Score: 111.46  E-value: 2.00e-34
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1021849228  3 QPDWHSADIIAALKKRGTSLSAVSRNSGLASATLANALIRHWPKGERLIAEALGTAPEQIWPSRYR 68
Cdd:COG3423    4 KKDWHPADIKAALRKRGTSLAALAREAGLSSSTLSNALTRPWPKGERAIAEALGVPPEEIWPSRYA 69
PRK10344 PRK10344
DNA-binding transcriptional regulator SfsB;
5-71 1.07e-30

DNA-binding transcriptional regulator SfsB;


Pssm-ID: 182394  Cd Length: 92  Bit Score: 103.12  E-value: 1.07e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1021849228  5 DWHSADIIAALKKRGTSLSAVSRNSGLASATLANALIRHWPKGERLIAEALGTAPEQIWPSRYRKPE 71
Cdd:PRK10344   7 DWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWVIWPSRYHDPQ 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH