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Conserved domains on  [gi|1015878456|ref|WP_062857976|]
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PTS sugar transporter subunit IIA, partial [Escherichia coli]

Protein Classification

PTS sugar transporter subunit IIA( domain architecture ID 10082877)

PTS sugar transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system, a major carbohydrate active transport system that catalyzes the phosphorylation of incoming sugar substrates, such as mannitol and fructose, concomitantly with their translocation across the cell membrane

CATH:  3.40.930.10
Gene Ontology:  GO:1902495|GO:0009401|GO:0016310|GO:0016301|GO:0008643
PubMed:  11532441|10393270
SCOP:  4001876

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 18-130 9.20e-34

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


:

Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 114.58  E-value: 9.20e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015878456  18 KDWREAVAISCRPLIENGSIEPRYVDAIYHSHDtIGPYYVvGPGIAMPHARPEEgANKLSLALTLIPSGVNFDADENDPV 97
Cdd:cd00211    13 KSKEEAIEELAQLLVAAGYVEEEYIEALLEREK-EGSTGI-GNGIAIPHAKSEA-VKKPGIAVLRLKEPVDFGSLDGQPV 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1015878456  98 KLLIVLAATDSTSHIEAISQLAKLFDNEKDIQA 130
Cdd:cd00211    90 HLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQ 122
 
Name Accession Description Interval E-value
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 18-130 9.20e-34

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 114.58  E-value: 9.20e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015878456  18 KDWREAVAISCRPLIENGSIEPRYVDAIYHSHDtIGPYYVvGPGIAMPHARPEEgANKLSLALTLIPSGVNFDADENDPV 97
Cdd:cd00211    13 KSKEEAIEELAQLLVAAGYVEEEYIEALLEREK-EGSTGI-GNGIAIPHAKSEA-VKKPGIAVLRLKEPVDFGSLDGQPV 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1015878456  98 KLLIVLAATDSTSHIEAISQLAKLFDNEKDIQA 130
Cdd:cd00211    90 HLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQ 122
PRK10372 PRK10372
PTS ascorbate transporter subunit IIA;
19-127 1.52e-33

PTS ascorbate transporter subunit IIA;


Pssm-ID: 182417 [Multi-domain]  Cd Length: 154  Bit Score: 114.69  E-value: 1.52e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015878456  19 DWREAVAISCRPLIENGSIEPRYVDAIYHSHDTIGPYYVVGPGIAMPHARPEEGANKLSLALTLIPSGVNFDADENDPVK 98
Cdd:PRK10372   21 TWQEAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPYFVIAPGLAMPHGRPEEGVKKTGFALVTLKKPLEFNHEDNDPVD 100

                          90       100       110
                  ....*....|....*....|....*....|
gi 1015878456  99 LLIVLAATDSTSHIE-AISQLAKLFDNEKD 127
Cdd:PRK10372  101 ILITMAAVDANTHQEvGIMQIVNLFEDEAN 130
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 1-130 4.00e-31

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 108.01  E-value: 4.00e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015878456   1 MLKNLLNTEVVQVVEQVKDWREAVAISCRPLIENGSI--EPRYVDAIYHSHDTIGPYyvVGPGIAMPHARPEeGANKLSL 78
Cdd:COG1762     2 MLSDLLTPELILLDLEASSKEEAIEELAELLAEKGYVldKEEYLEALLEREELGSTG--IGPGIAIPHARPE-GVKKPGI 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1015878456  79 ALTLIPSGVNFDADENDPVKLLIVLAA--TDSTSHIEAISQLAKLFDNEKDIQA 130
Cdd:COG1762    79 AVARLKEPVDFGAMDGEPVDLVFLLAApeDDSEEHLKLLAELARLLSDEEFREK 132
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
18-130 2.02e-29

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 103.44  E-value: 2.02e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015878456  18 KDWREAVAISCRPLIENGSIEPRYVDAIYHSHDTIGPYYvvGPGIAMPHARPeEGANKLSLALTLIPSGVNFDADENDPV 97
Cdd:pfam00359  14 KSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGI--GNGIAIPHARS-EAVKKPGIAVLTLKEPVDFGSEDGKPV 90

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1015878456  98 KLLIVLAATDSTS-HIEAISQLAKLFDNEKDIQA 130
Cdd:pfam00359  91 KLIFLLAAPDNEAsHLKILSQLARLLQDEEFVEK 124
fruA TIGR00848
PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family ...
 58-130 2.08e-09

PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Fru family is a large and complex family which includes several sequenced fructose and mannitol-specific permeases as well as several putative PTS permeases of unknown specificities. The fructose permeases of this family phosphorylate fructose on the 1-position. Those of family 4.6 phosphorylate fructose on the 6-position. The Fru family PTS systems typically have 3 domains, IIA, IIB and IIC, which may be found as 1 or more proteins. The fructose and mannitol transporters form separate phylogenetic clusters in this family. This model is specific for the IIA domain of the fructose PTS transporters. Also similar to the Enzyme IIA Fru subunits of the PTS, but included in TIGR01419 rather than this model, is enzyme IIA Ntr (nitrogen), also called PtsN, found in E. coli and other organisms, which may play a solely regulatory role. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273298 [Multi-domain]  Cd Length: 129  Bit Score: 51.89  E-value: 2.08e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015878456  58 VGPGIAMPHARpEEGANKLSLALTLIPSGVNFDADENDPVKLLIVLAATDS---TSHIEAISQLAKLFDNEKDIQA 130
Cdd:TIGR00848  54 IGDGVAIPHAK-SAAVKQPFVAIARLVKGVDWQSLDGKPVKLIFLIAVPKDeagNTHLKALSQLARLLLNDEFRAK 128
 
Name Accession Description Interval E-value
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 18-130 9.20e-34

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 114.58  E-value: 9.20e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015878456  18 KDWREAVAISCRPLIENGSIEPRYVDAIYHSHDtIGPYYVvGPGIAMPHARPEEgANKLSLALTLIPSGVNFDADENDPV 97
Cdd:cd00211    13 KSKEEAIEELAQLLVAAGYVEEEYIEALLEREK-EGSTGI-GNGIAIPHAKSEA-VKKPGIAVLRLKEPVDFGSLDGQPV 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1015878456  98 KLLIVLAATDSTSHIEAISQLAKLFDNEKDIQA 130
Cdd:cd00211    90 HLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQ 122
PRK10372 PRK10372
PTS ascorbate transporter subunit IIA;
19-127 1.52e-33

PTS ascorbate transporter subunit IIA;


Pssm-ID: 182417 [Multi-domain]  Cd Length: 154  Bit Score: 114.69  E-value: 1.52e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015878456  19 DWREAVAISCRPLIENGSIEPRYVDAIYHSHDTIGPYYVVGPGIAMPHARPEEGANKLSLALTLIPSGVNFDADENDPVK 98
Cdd:PRK10372   21 TWQEAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPYFVIAPGLAMPHGRPEEGVKKTGFALVTLKKPLEFNHEDNDPVD 100

                          90       100       110
                  ....*....|....*....|....*....|
gi 1015878456  99 LLIVLAATDSTSHIE-AISQLAKLFDNEKD 127
Cdd:PRK10372  101 ILITMAAVDANTHQEvGIMQIVNLFEDEAN 130
cmtB PRK09854
PTS mannitol transporter subunit IIA;
18-126 5.41e-33

PTS mannitol transporter subunit IIA;


Pssm-ID: 182114 [Multi-domain]  Cd Length: 147  Bit Score: 112.78  E-value: 5.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015878456  18 KDWREAVAISCRPLIENGSIEPRYVDAIYHSHDTIGPYYVVGPGIAMPHARPEEGANKLSLALTLIPSGVNFdADENDPV 97
Cdd:PRK09854   19 KDWQEAIDFSMVSLLDKNYISENYIQAIKDSTINNGPYYILAPGVAMPHARPECGALKTGMSLTLLEQGVYF-PGNDEPI 97

                          90       100
                  ....*....|....*....|....*....
gi 1015878456  98 KLLIVLAATDSTSHIEAISQLAKLFDNEK 126
Cdd:PRK09854   98 KLLIGLSAADADSHIGAIQALSELLCEEE 126
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 1-130 4.00e-31

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 108.01  E-value: 4.00e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015878456   1 MLKNLLNTEVVQVVEQVKDWREAVAISCRPLIENGSI--EPRYVDAIYHSHDTIGPYyvVGPGIAMPHARPEeGANKLSL 78
Cdd:COG1762     2 MLSDLLTPELILLDLEASSKEEAIEELAELLAEKGYVldKEEYLEALLEREELGSTG--IGPGIAIPHARPE-GVKKPGI 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1015878456  79 ALTLIPSGVNFDADENDPVKLLIVLAA--TDSTSHIEAISQLAKLFDNEKDIQA 130
Cdd:COG1762    79 AVARLKEPVDFGAMDGEPVDLVFLLAApeDDSEEHLKLLAELARLLSDEEFREK 132
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
18-130 2.02e-29

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 103.44  E-value: 2.02e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015878456  18 KDWREAVAISCRPLIENGSIEPRYVDAIYHSHDTIGPYYvvGPGIAMPHARPeEGANKLSLALTLIPSGVNFDADENDPV 97
Cdd:pfam00359  14 KSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGI--GNGIAIPHARS-EAVKKPGIAVLTLKEPVDFGSEDGKPV 90

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1015878456  98 KLLIVLAATDSTS-HIEAISQLAKLFDNEKDIQA 130
Cdd:pfam00359  91 KLIFLLAAPDNEAsHLKILSQLARLLQDEEFVEK 124
MtlA2 COG4668
Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and ...
 18-130 5.01e-16

Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism];


Pssm-ID: 443705 [Multi-domain]  Cd Length: 143  Bit Score: 69.42  E-value: 5.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015878456  18 KDWREAVAISCRPLIENGSIEPRYVDAIYHSHDTIGPYyvVGPGIAMPHARPE--EGANKLSLALTLIPSGVNFdaDEND 95
Cdd:COG4668    16 ANKEEAIRLAGQLLVEAGYVEPEYIDAMLEREAQVSTY--LGNGIAIPHGTNEakDLVLKTGISVLQFPDGVDW--GDGN 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1015878456  96 PVKLLIVLAATdSTSHIEAISQLAKLFDNEKDIQA 130
Cdd:COG4668    92 TVYLVIGIAAK-SDEHLEILRQLARVLSDEENVEK 125
PRK15083 PRK15083
PTS system mannitol-specific transporter subunit IICBA; Provisional
 22-129 1.14e-09

PTS system mannitol-specific transporter subunit IICBA; Provisional


Pssm-ID: 237905 [Multi-domain]  Cd Length: 639  Bit Score: 54.67  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015878456  22 EAVAISCRPLIENGSIEPRYVDAIYHSHDTIGPYyvVGPGIAMPHARPE--EGANKLSLALTLIPSGVNFDADENDPVKL 99
Cdd:PRK15083  513 EAIRFAGEQLVKGGYVEPEYVDAMLDREKLTSTY--LGESIAVPHGTVEakDRVLKTGVVFCQYPEGVRFGEEEDDIARL 590

                          90       100       110
                  ....*....|....*....|....*....|
gi 1015878456 100 LIVLAATDStSHIEAISQLAKLFDNEKDIQ 129
Cdd:PRK15083  591 VIGIAARNN-EHIQVITSLTNALDDESVIE 619
fruA TIGR00848
PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family ...
 58-130 2.08e-09

PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Fru family is a large and complex family which includes several sequenced fructose and mannitol-specific permeases as well as several putative PTS permeases of unknown specificities. The fructose permeases of this family phosphorylate fructose on the 1-position. Those of family 4.6 phosphorylate fructose on the 6-position. The Fru family PTS systems typically have 3 domains, IIA, IIB and IIC, which may be found as 1 or more proteins. The fructose and mannitol transporters form separate phylogenetic clusters in this family. This model is specific for the IIA domain of the fructose PTS transporters. Also similar to the Enzyme IIA Fru subunits of the PTS, but included in TIGR01419 rather than this model, is enzyme IIA Ntr (nitrogen), also called PtsN, found in E. coli and other organisms, which may play a solely regulatory role. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273298 [Multi-domain]  Cd Length: 129  Bit Score: 51.89  E-value: 2.08e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015878456  58 VGPGIAMPHARpEEGANKLSLALTLIPSGVNFDADENDPVKLLIVLAATDS---TSHIEAISQLAKLFDNEKDIQA 130
Cdd:TIGR00848  54 IGDGVAIPHAK-SAAVKQPFVAIARLVKGVDWQSLDGKPVKLIFLIAVPKDeagNTHLKALSQLARLLLNDEFRAK 128
nitro_reg_IIA TIGR01419
PTS IIA-like nitrogen-regulatory protein PtsN; This model describes a full-length protein of ...
 58-128 2.20e-08

PTS IIA-like nitrogen-regulatory protein PtsN; This model describes a full-length protein of about 160 residues closely related to the fructose-specific phosphotransferase (PTS) system IIA component. It is a regulatory protein found only in species with a phosphoenolpyruvate-protein phosphotransferase (enzyme I of PTS systems) and an HPr-like phosphocarrier protein, but not all species have a IIC-like permease. Members of this family are found in Proteobacteria, Chlamydia, and the spirochete Treponema pallidum. [Signal transduction, PTS]


Pssm-ID: 162350 [Multi-domain]  Cd Length: 145  Bit Score: 49.33  E-value: 2.20e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1015878456  58 VGPGIAMPHARPEEGANKLSLALTLiPSGVNFDADENDPVKLLIVLAATDSTS--HIEAISQLAKLFDnEKDI 128
Cdd:TIGR01419  57 VGNGIAIPHGRLSGLKQPVGVFIRL-DAPVDFDALDGKPVDLLFALLVPENATaeHLEALSRIARKLS-DKTI 127
PRK10896 PRK10896
PTS IIA-like nitrogen regulatory protein PtsN;
58-120 1.71e-04

PTS IIA-like nitrogen regulatory protein PtsN;


Pssm-ID: 182818 [Multi-domain]  Cd Length: 154  Bit Score: 38.97  E-value: 1.71e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1015878456  58 VGPGIAMPHARPEEGANKLSLALTLIPSGVNFDADENDPVKLLIVL--AATDSTSHIEAISQLAK 120
Cdd:PRK10896   64 IGNGIAIPHGKLEEDTLRAVGVFVQLEQPIAFDAIDNQPVDLLFALlvPADQCKTHLHTLSLVAK 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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