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Conserved domains on  [gi|1011946562|ref|WP_062754487|]
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MULTISPECIES: MFS transporter [Bacillaceae]

Protein Classification

MFS transporter( domain architecture ID 13022776)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
12-386 4.16e-72

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 229.41  E-value: 4.16e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  12 LGVAGLGWMFDAMDVGMLSFIIAALQK--DWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGS 89
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  90 GLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIP----TYGWQT 165
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 166 ALLLAAIPALYALYLrwglpdsprftsarkeetvwdnivkvwsssyRKETFMLWVLWFCVVFSYYGMFLWLPSVMVM-KG 244
Cdd:cd17316   161 LFLIGALPALLALLL-------------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLG 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 245 FSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNA--DSLALLMTFGILLSFFNLGAWGAL 322
Cdd:cd17316   210 LSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGAL 289
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011946562 323 YAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVW 386
Cdd:cd17316   290 YAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
 
Name Accession Description Interval E-value
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
12-386 4.16e-72

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 229.41  E-value: 4.16e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  12 LGVAGLGWMFDAMDVGMLSFIIAALQK--DWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGS 89
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  90 GLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIP----TYGWQT 165
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 166 ALLLAAIPALYALYLrwglpdsprftsarkeetvwdnivkvwsssyRKETFMLWVLWFCVVFSYYGMFLWLPSVMVM-KG 244
Cdd:cd17316   161 LFLIGALPALLALLL-------------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLG 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 245 FSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNA--DSLALLMTFGILLSFFNLGAWGAL 322
Cdd:cd17316   210 LSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGAL 289
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011946562 323 YAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVW 386
Cdd:cd17316   290 YAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
8-361 1.17e-66

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 216.84  E-value: 1.17e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   8 QRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSI 87
Cdd:TIGR00895  15 QWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  88 GSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTAL 167
Cdd:TIGR00895  95 FTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLF 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 168 LLAAIP-ALYALYLRWGLPDSPRFTSARKEETV----------------------------WDNIVKV-WSSSYRKETFM 217
Cdd:TIGR00895 175 YVGGIApLLLLLLLMRFLPESIDFLVSKRPETVrrivnaiapqmqaeaqsalpeqkstqgtKRSVFKAlFQGKTARITVL 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 218 LWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGN 297
Cdd:TIGR00895 255 LWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGST 334
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011946562 298 ADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLV 361
Cdd:TIGR00895 335 LFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
8-394 4.10e-60

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 198.56  E-value: 4.10e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   8 QRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSI 87
Cdd:COG2271     8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  88 GSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTAL 167
Cdd:COG2271    88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 168 LLAAIPALYALYLRwglpdsprftsarkeetvwdnivkvwsssyrkeTFMLWVLWFCVVFSYYGMFLWLPSVMV-MKGFS 246
Cdd:COG2271   168 LILGLPGLLLALLR---------------------------------FWLLALAYFLVYFALYGFLTWLPTYLVeVRGLS 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 247 LIKSFEYVLIMTLAQLPGYFSAAWLIERAGR--KFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYA 324
Cdd:COG2271   215 LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWA 294
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 325 YTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVWVLGKETKQ 394
Cdd:COG2271   295 LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD-ATGYQAAFLLLAALALLAALLALLLLRETRK 363
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
33-360 2.06e-50

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 174.38  E-value: 2.06e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  33 IAA--LQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGM 110
Cdd:PRK11551   36 VAAprMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGV 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 111 GLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYL--RWgLPDSP 188
Cdd:PRK11551  116 GLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLlmRW-LPESR 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 189 RFTSARKEETVWDNIVKV-WSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSfEYVLIM-TLAQLPGYF 266
Cdd:PRK11551  195 AFAQAAGAGKQRAPVLRAlFGEGRATATLLLWISYFFTLIVLYFLLNWLPSLLVGQGLSRSQA-GLVQIAfNIGGALGSL 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 267 SAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFG 346
Cdd:PRK11551  274 LIGALMDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVG 353
                         330
                  ....*....|....
gi 1011946562 347 RIGGILGPLFVGYL 360
Cdd:PRK11551  354 RLGSMAGPLLAGQL 367
MFS_1 pfam07690
Major Facilitator Superfamily;
20-354 2.84e-33

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 127.15  E-value: 2.84e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  20 MFDAMDVGMLSFIIA-ALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTL 98
Cdd:pfam07690   6 FLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  99 TAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYAL 178
Cdd:pfam07690  86 WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 179 YLRWGLPDSPRFTSARKEETVWDNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMT 258
Cdd:pfam07690 166 VLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGG 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 259 LAQLPGYFSAAWLIERAGRK---FVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIR 335
Cdd:pfam07690 246 LLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER 325
                         330
                  ....*....|....*....
gi 1011946562 336 GTGAGMAASFGRIGGILGP 354
Cdd:pfam07690 326 GTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
12-386 4.16e-72

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 229.41  E-value: 4.16e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  12 LGVAGLGWMFDAMDVGMLSFIIAALQK--DWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGS 89
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  90 GLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIP----TYGWQT 165
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 166 ALLLAAIPALYALYLrwglpdsprftsarkeetvwdnivkvwsssyRKETFMLWVLWFCVVFSYYGMFLWLPSVMVM-KG 244
Cdd:cd17316   161 LFLIGALPALLALLL-------------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLG 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 245 FSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNA--DSLALLMTFGILLSFFNLGAWGAL 322
Cdd:cd17316   210 LSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGAL 289
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011946562 323 YAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVW 386
Cdd:cd17316   290 YAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
8-361 1.17e-66

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 216.84  E-value: 1.17e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   8 QRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSI 87
Cdd:TIGR00895  15 QWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  88 GSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTAL 167
Cdd:TIGR00895  95 FTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLF 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 168 LLAAIP-ALYALYLRWGLPDSPRFTSARKEETV----------------------------WDNIVKV-WSSSYRKETFM 217
Cdd:TIGR00895 175 YVGGIApLLLLLLLMRFLPESIDFLVSKRPETVrrivnaiapqmqaeaqsalpeqkstqgtKRSVFKAlFQGKTARITVL 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 218 LWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGN 297
Cdd:TIGR00895 255 LWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGST 334
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011946562 298 ADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLV 361
Cdd:TIGR00895 335 LFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
12-389 2.06e-65

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 212.06  E-value: 2.06e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  12 LGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGL 91
Cdd:cd17365     1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  92 SALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAA 171
Cdd:cd17365    81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 172 IPALYALYLRWGlpdsprftsarkeetvwdnivkvwsssyrkeTFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSF 251
Cdd:cd17365   161 VPPLILLPLLRG-------------------------------TLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQAL 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 252 EYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFG-NADSLALLMTFGILLSFFNLGAWGALYAYTPELY 330
Cdd:cd17365   210 TITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGvSPASLVLLYVLVFLAGACVNGAQVGLYALAARFY 289
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1011946562 331 PTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVWVLG 389
Cdd:cd17365   290 PTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLR 348
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
12-392 9.43e-64

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 209.08  E-value: 9.43e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  12 LGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGL 91
Cdd:cd17371     1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  92 SALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIP----TYGWQTAL 167
Cdd:cd17371    81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRVLF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 168 LLAAIPALYALYLRWGLPDSPRFTSARKEETVWDNIVKVWSSSYRK--ETFMLWVLWFCVV-FSYYGMFLWLPSVM-VMK 243
Cdd:cd17371   161 LLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELFSPPllRTTLLASLLATGAlGGYYGITTWLPSYLtGER 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 244 GFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVS--AYFFGNADsLALLMTFGILLSFFNLGAWGA 321
Cdd:cd17371   241 GLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISilLYFFLPLS-PTLILILGFPLGFFASGPFSG 319
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011946562 322 LYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVWVLGKET 392
Cdd:cd17371   320 MGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLAT-SGSLGTAIAVFAAVYYIAGLVLALLLPET 389
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
8-394 4.10e-60

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 198.56  E-value: 4.10e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   8 QRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSI 87
Cdd:COG2271     8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  88 GSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTAL 167
Cdd:COG2271    88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 168 LLAAIPALYALYLRwglpdsprftsarkeetvwdnivkvwsssyrkeTFMLWVLWFCVVFSYYGMFLWLPSVMV-MKGFS 246
Cdd:COG2271   168 LILGLPGLLLALLR---------------------------------FWLLALAYFLVYFALYGFLTWLPTYLVeVRGLS 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 247 LIKSFEYVLIMTLAQLPGYFSAAWLIERAGR--KFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYA 324
Cdd:COG2271   215 LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWA 294
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 325 YTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVWVLGKETKQ 394
Cdd:COG2271   295 LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD-ATGYQAAFLLLAALALLAALLALLLLRETRK 363
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
33-360 2.06e-50

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 174.38  E-value: 2.06e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  33 IAA--LQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGM 110
Cdd:PRK11551   36 VAAprMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGV 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 111 GLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYL--RWgLPDSP 188
Cdd:PRK11551  116 GLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLlmRW-LPESR 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 189 RFTSARKEETVWDNIVKV-WSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSfEYVLIM-TLAQLPGYF 266
Cdd:PRK11551  195 AFAQAAGAGKQRAPVLRAlFGEGRATATLLLWISYFFTLIVLYFLLNWLPSLLVGQGLSRSQA-GLVQIAfNIGGALGSL 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 267 SAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFG 346
Cdd:PRK11551  274 LIGALMDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVG 353
                         330
                  ....*....|....
gi 1011946562 347 RIGGILGPLFVGYL 360
Cdd:PRK11551  354 RLGSMAGPLLAGQL 367
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
14-388 2.36e-46

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 162.70  E-value: 2.36e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  14 VAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSA 93
Cdd:cd17372     3 YAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  94 LTTTLTAFLVLRFLIGMGLGGeLPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWqtalllaaip 173
Cdd:cd17372    83 FAPNYMWLIILRCLVGLGLGG-GPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGW---------- 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 174 alyalylRWGLpdspRFTSarkeetVWDNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFL----WLPSVMVMKGFSLIK 249
Cdd:cd17372   152 -------RWLL----AFSS------VPSSLLLVFYRWTPKTTLLLWVIWFGNAFAYYGVVLltteLNNSHNVCGSKSDSD 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 250 SFEY----------------VLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSF 313
Cdd:cd17372   215 SGESptekqcrnsndvdyrdVFIATFAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLLICQSPFILTVLLFGGRA 294
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011946562 314 FNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITITtiFLIFCISIFIGVIAVWVL 388
Cdd:cd17372   295 CISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLVHGSQTIA--LLLFSVVCLVSAICVCLL 367
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
12-357 1.10e-45

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 164.03  E-value: 1.10e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  12 LGVAGLGWMFDAMDVGMLSFII--AALQKDWNLSVEQMGWIG---SINSIGMAVGALLFGLLADRIGRKNVFIITLLLFS 86
Cdd:TIGR00898  89 LSDLGLAATEPCLDGWEYSYDTfsSTIVTEWDLVCEDAWKVDltqSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTA 168
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  87 IGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPtygWQTA 166
Cdd:TIGR00898 169 VSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---WRWL 245
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 167 LLLAAIPALYALYLRWGLPDSPRF--TSARKEETV---------------------------------WDNIVKVWSSSY 211
Cdd:TIGR00898 246 QLAVSLPTFLFFLLSWFVPESPRWliSQGRIEEALkilqriakingkklpaevlslslekdlssskkqYSFLDLFRTPNL 325
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 212 RKETFMLWVLWFCVVFSYYGMFLWLPSVmvmkGFSLIKSFeyvLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVS 291
Cdd:TIGR00898 326 RKTTLCLMMLWFTTAFSYYGLVLDLGNL----GGNIYLDL---FISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVA 398
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1011946562 292 AYF-FGNADSLALLMTFGILLS-FFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFV 357
Cdd:TIGR00898 399 LLLlLFVPVDLYFLRTALAVLGkFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLV 466
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-352 1.93e-44

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 157.06  E-value: 1.93e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   1 MIQQTISQRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFII 80
Cdd:COG2814     1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  81 TLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPT 160
Cdd:COG2814    81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 161 YGWQTALLLAAIPALYALYLRW-GLPDSPRFTSARKEETVWDNIvkvwsssYRKETFMLWVLWFCVVFSYYGMFLWLPSV 239
Cdd:COG2814   161 FGWRWVFLVNAVLALLALLLLLrLLPESRPAARARLRGSLRELL-------RRPRLLLLLLLAFLLGFGFFALFTYLPLY 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 240 MV-MKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGA 318
Cdd:COG2814   234 LQeVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLL 313
                         330       340       350
                  ....*....|....*....|....*....|....
gi 1011946562 319 WGALYAYTPELYPTSIRGTGAGMAASFGRIGGIL 352
Cdd:COG2814   314 FPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
16-384 1.29e-42

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 153.04  E-value: 1.29e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  16 GLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALT 95
Cdd:cd17441     5 GLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  96 TTLTAFLVLRFLIGMGLGGeLPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPAL 175
Cdd:cd17441    85 PIYSWILVLRGLVGFGIGG-VPQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 176 YALYLRWGLPDSPRFtsarkeetvwdnivkvwsssyrKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYV- 254
Cdd:cd17441   164 IFAVLCFWLPESARY----------------------WTTILLWFIWFSNAFSYYGLVLLTTELFQAGDVCSGSSGKKVe 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 255 ------------------LIMTLAQLPGYFSAAWLIERAGRKFVL-ITYLIGTAVSAYFFGNADSLALLMTFGILLSFFN 315
Cdd:cd17441   222 gkcsleceylttsdymdlLWTTLSEFPGLLVTLWIIDRFGRKKTMaLCFFVFSFCTLLLFSCVGRFSLTVLLFIARAFIS 301
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1011946562 316 lGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITITtiFLIFCISIFIGVIA 384
Cdd:cd17441   302 -GGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLT--LSVYSGCCLLAAIA 367
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
7-396 2.14e-42

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 152.73  E-value: 2.14e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   7 SQRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFS 86
Cdd:COG2223     2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  87 IGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQ-T 165
Cdd:COG2223    82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRnA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 166 ALLLAAIPALYALYLRWGLPDSPRFTSARKEETVWDnIVKVWSSsyrKETFMLWVLWFCVVFSYYGMFLWLPSVMV-MKG 244
Cdd:COG2223   162 FLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRD-QLEALRD---PRFWLLSLLYFGTFGSFIGFSSWLPPYLVdQFG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 245 FSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAW-GALY 323
Cdd:COG2223   238 LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGnGAVF 317
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011946562 324 AYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVWVLGKETKQQE 396
Cdd:COG2223   318 ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
39-388 5.55e-35

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 131.55  E-value: 5.55e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  39 DWNLSVEQ---MGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGE 115
Cdd:cd17317    16 EWDLVCDRdwlVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGI 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 116 LPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFvIPTygWQTALLLAAIPALYALYLRWGLPdsprftsark 195
Cdd:cd17317    96 FTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYL-IRD--WRWLQLAISLPGLLFLLLLWWLP---------- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 196 eetvwdnivkvwsssyrKETFMLWVLWFCVVFSYYGMFLWLPSVmvmkGFSLIKSFeyvLIMTLAQLPGYFSAAWLIERA 275
Cdd:cd17317   163 -----------------RRTIIVGLIWFVTSLVYYGLSLNSSNL----GGNLYLNF---FLSGLVEIPAYFLALLLLDRL 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 276 GRKFVLITYLIGTAVSAYF--FGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILG 353
Cdd:cd17317   219 GRRWTLSGSLLLAGLACLVtaLLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILA 298
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1011946562 354 PlFVGYLVNRHITITtiFLIFCISIFIGVIAVWVL 388
Cdd:cd17317   299 P-FIVLLGKIGPLLP--LIIFGVLALLGGLLTLLL 330
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
14-361 1.21e-33

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 130.69  E-value: 1.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  14 VAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSA 93
Cdd:cd17363     3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  94 LTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYG----------- 162
Cdd:cd17363    83 FVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGwgfsmgtayqf 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 163 --WQTALLLAAIPALYALYLRWGLPDSPRF--TSARKEET------VWDNIV-------KVWSSSY--RKETFMLWVLWF 223
Cdd:cd17363   163 hsWRVFVIVCALPSVASVVALTFMPESPRFllEVGKHDEAwmilkqVHDTNMrakghpeRVFTVSHikRMNTLFLAIVWF 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 224 CVVFSYYGMFLWLPSVMVMKGF--SLIKS----------------------------FEYVLIM---------------- 257
Cdd:cd17363   243 TMSFSYYGLTVWFPDMIKYLQFedSLFEEcyfedvtstntffenctfintvfyntdlFEYKFIDsrflnstfflkekcgc 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 258 -------------------TLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYF--FGNADSlallMTFGILLSFFNL 316
Cdd:cd17363   323 hlnddeenayliylvsflgSLSVLPGNIVSALLMDKIGRLKMIGGSMLLSAVCCFFlfFGNSES----AMIGLQCLFCGV 398
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1011946562 317 G--AWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLV 361
Cdd:cd17363   399 SiaAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSIFGSFV 445
MFS_1 pfam07690
Major Facilitator Superfamily;
20-354 2.84e-33

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 127.15  E-value: 2.84e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  20 MFDAMDVGMLSFIIA-ALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTL 98
Cdd:pfam07690   6 FLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  99 TAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYAL 178
Cdd:pfam07690  86 WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 179 YLRWGLPDSPRFTSARKEETVWDNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMT 258
Cdd:pfam07690 166 VLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGG 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 259 LAQLPGYFSAAWLIERAGRK---FVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIR 335
Cdd:pfam07690 246 LLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER 325
                         330
                  ....*....|....*....
gi 1011946562 336 GTGAGMAASFGRIGGILGP 354
Cdd:pfam07690 326 GTASGLYNTAGSLGGALGP 344
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
11-388 3.68e-32

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 124.61  E-value: 3.68e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  11 LLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSG 90
Cdd:cd17319     4 IIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  91 LSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLA 170
Cdd:cd17319    84 LTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 171 AIPAlyalyLRWGLpdsprftsarkeetvwdnivkVWSSSYRKeTFMLWVLWFCVVFSYYGMFLWLPSVMV-MKGFSLIK 249
Cdd:cd17319   164 GLLG-----LLLAV---------------------LWWFYLRQ-VWGLALGYFGINYALYGLLTWLPTYLKqARGFSLKQ 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 250 ----SFEYVLIMTLAQLPGYFSAAWLIERAgRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAY 325
Cdd:cd17319   217 vgllAAIPFLAGAIGMILGGRLSDRLLRGA-RRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSL 295
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011946562 326 TPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVWVL 388
Cdd:cd17319   296 PADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
PRK12307 PRK12307
MFS transporter;
3-381 4.78e-32

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 125.43  E-value: 4.78e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   3 QQTISQRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITL 82
Cdd:PRK12307   11 EITRPQKNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSI 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  83 LLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYG 162
Cdd:PRK12307   91 VAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYG 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 163 WQTALLLAAIPALYALYLRWGLPDSPRFTSAR------KEETVWDNIVKVWSSSYRKETFMLWVLWFCVVFSYYG----M 232
Cdd:PRK12307  171 WRAAFFVGLLPVLLVIYIRARAPESKEWEEAKlsgkgkHSQSAWSVFSLSMKGLFNRAQFPLTLCVFIVLFSIFGanwpI 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 233 FLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAY--FFGNADSLALLMTFGIL 310
Cdd:PRK12307  251 FGLLPTYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFplFRIPQDNYLLLGACLFG 330
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011946562 311 LSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYL-----VNRHITITTIFLIFCISIFIG 381
Cdd:PRK12307  331 LMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLgitmgLGAALTFIVAFWTATILLIIG 406
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
14-353 5.60e-32

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 126.30  E-value: 5.60e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  14 VAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSA 93
Cdd:cd17439     3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  94 LTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIP 173
Cdd:cd17439    83 FVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFQMGSAYQF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 174 ALYALYL-------------RWGLPDSPRF-TSARKEETVWDNIVKVWSSSY----------------RKETFMLWVLWF 223
Cdd:cd17439   163 HSWRVFVlvcafpsvfaigaLTTMPESPRFfLENGKHDEAWMVLKQVHDTNMrakghpervfsvthikRRITLMMMAVWF 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 224 CVVFSYYGMFLWLPSVM---------------------------VMKGFSLIKS-------FEYVLIM------------ 257
Cdd:cd17439   243 TMSFSYYGLTVWFPDMIkhlqksvvfedslfeecyfeditssntFFKNCTFISTlfyntdlFEYKFINsklinstflhnk 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 258 -----------------------TLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYF--FGNADS--LALLMTFGIL 310
Cdd:cd17439   323 egclldfsdennaymiyfvsflgTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFlsFGNSESamIALLCLFGGV 402
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1011946562 311 lsffNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILG 353
Cdd:cd17439   403 ----SIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLG 441
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
14-353 2.26e-31

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 124.26  E-value: 2.26e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  14 VAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSA 93
Cdd:cd17438     3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  94 LTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIP 173
Cdd:cd17438    83 FVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWGFSMGTNYHF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 174 ALYALY--------------LRWgLPDSPRF-TSARKEETVW----------------DNIVKVWSSSYRKETFMLWVLW 222
Cdd:cd17438   163 HSWRVFviicalpciasiiaLKF-MPESPRFlLEMGKHDEAWmilknihdtnmrakgtPEKVFTVSNIKRKNTLFLAVVW 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 223 FCVVFSYYGMFLWLPSVM---------------------------VMKGFSLIKSFEY---------------------- 253
Cdd:cd17438   242 FTMAFSYYGLTVWFPDMIrylqkhvtfedslfdecyfedvtstdtYFKNCTIESTIFYntdlyehkfidcrfinstfleq 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 254 -------------VLIM------TLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAY--FFGNADSlaLLMTFGILLS 312
Cdd:cd17438   322 kegchmdfeedndFLIYlvsflgSLSVLPGNIISALLMDKIGRIKMIGGSMLISAVCCFflFFGNSES--AMIGWQCLFC 399
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1011946562 313 FFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILG 353
Cdd:cd17438   400 GTSIAAWNALDVITVELYPTNKRATAFGILNGLCKFAAILG 440
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
8-361 5.88e-31

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 125.09  E-value: 5.88e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   8 QRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSI 87
Cdd:TIGR01299 165 QWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGF 244
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  88 GSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTAL 167
Cdd:TIGR01299 245 FAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWSFQM 324
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 168 LLAAIPALYALYL-------------RWGLPDSPRF--------------------------------------TSARKE 196
Cdd:TIGR01299 325 GSAYQFHSWRVFVivcafpcvfaigaLTFMPESPRFflengkhdeawmilklihdtnmrakghpekvfsvnhikTIHQED 404
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 197 E------------------------TVWDNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVM------------ 240
Cdd:TIGR01299 405 ElieiesdtgtwyqrcfvralseggGIWGNFLRCFNPEVREITIKLMGVWFTLSFGYYGLSVWFPDMIkhlqaddyaalt 484
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 241 --------------------VMKGF-------------------SLIKS----------------------------FEY 253
Cdd:TIGR01299 485 knfpgdkvahfsfnftlenqIHRGGeydndkfiglkfksvsfedSLFEEctfddvtssntffknctfidtlfentdfEEY 564
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 254 VLIM------------------------------------TLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYF--F 295
Cdd:TIGR01299 565 KFIDsefqncsflhnkegcpidfdgddegaymiyfvnflgTLAVLPGNIVSALLMDKIGRLRMLAGSMVLSCISCFFlsF 644
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1011946562 296 GNADS--LALLMTFGILlsffNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLV 361
Cdd:TIGR01299 645 GNSESamIALLCLFGGL----SIAAWNALDVLTVELYPSDKRATAFGFLNALCKAAAVLGILIFGSFV 708
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
14-392 1.78e-30

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 120.46  E-value: 1.78e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  14 VAGLGWMFDAMDVGMLSFIIAALQKDW-----NLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIG 88
Cdd:cd17364     3 IAGMGFFTDAYDLFSISLVTKILGRLYyggkgSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  89 SGLSAL------TTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYG 162
Cdd:cd17364    83 TILSALspgstpLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIFE 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 163 wqtalllaaipalyalylrwglpDSPRFTSARKEETVWDNIV---KVWSSS---YRKETFMLWVLWFCVVFSYYGMFLWL 236
Cdd:cd17364   163 -----------------------HPLPAGTYHHADLVWRIVLglgAIPALSvlyFRKHLLGTAGTWFLLDIAFYGQNLFQ 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 237 PSVMVMKGFS---------LIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAV------SAYFFGNADSL 301
Cdd:cd17364   220 STIISAIGFSktmnayqelFNIAVGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTIfllilaGPYDHWKISTI 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 302 ALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNrHITITTIFLIFCISIFIG 381
Cdd:cd17364   300 GFFVLYGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQ-NIGVRNVLIILAGVALLG 378
                         410
                  ....*....|.
gi 1011946562 382 VIAVWVLGKET 392
Cdd:cd17364   379 IILTLLFPEEK 389
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
7-295 3.92e-30

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 117.60  E-value: 3.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   7 SQRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFS 86
Cdd:COG0477    11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  87 IGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTA 166
Cdd:COG0477    91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 167 LLLAAIPALYALYLRWGLPDSPRFTSARkeetVWDNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFS 246
Cdd:COG0477   171 FLINAPLGLLALVLRLRLPESRGLLLAL----LALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL 246
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1011946562 247 LIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFF 295
Cdd:COG0477   247 LLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
14-361 4.39e-30

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 120.79  E-value: 4.39e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  14 VAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSA 93
Cdd:cd17440     3 VLGMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  94 LTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIP 173
Cdd:cd17440    83 FVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 174 ALYALYL-------------RWGLPDSPRF-TSARKEETVWDNIVKVWSSSYR----------------KETFMLWVLWF 223
Cdd:cd17440   163 HSWRVFVivcalpcvssvvaLTFMPESPRFlLEVGKHDEAWMILKQIHDTNMRargqpekvftvnrikkDNTIKLTIVWL 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 224 CVVFSYYGMFLWLPSVMVMKGF-------SLIKS--FEYVLIM------------------------------------- 257
Cdd:cd17440   243 TLSFGYYGLSVWFPDVIKHLQFksvtfedSLFKScfFEDVTSVntyfrnctfietvfyntdledykfidsdfinctffhn 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 258 ------------------------TLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSF 313
Cdd:cd17440   323 ktgcqitfdddysaywiyfvnflgTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNG 402
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1011946562 314 FNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLV 361
Cdd:cd17440   403 LTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLV 450
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
21-386 6.19e-30

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 118.83  E-value: 6.19e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  21 FDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTA 100
Cdd:cd17325     7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 101 FLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYL 180
Cdd:cd17325    87 LLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 181 RWGLPDSPRFTSARKEETVWDNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMK-GFSLIKSFEYVLIMTL 259
Cdd:cd17325   167 ALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGL 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 260 AQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGA 339
Cdd:cd17325   247 ASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAM 326
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1011946562 340 GMAASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVW 386
Cdd:cd17325   327 GLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
15-386 1.38e-29

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 117.91  E-value: 1.38e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  15 AGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSAL 94
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  95 TTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVI--PTYGWQTALLLAAI 172
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 173 PALYALYLRWGLPDSPRFTSARKEETVW--DNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKS 250
Cdd:cd06174   161 LALLAAILLLLVVPDPPESARAKNEEASskSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 251 FEYVLIMT-LAQLPGYFSAAWLIER-AGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPE 328
Cdd:cd06174   241 AGLLLSLFgLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1011946562 329 LYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVW 386
Cdd:cd06174   321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
7-395 3.14e-29

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 116.88  E-value: 3.14e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   7 SQRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFS 86
Cdd:COG0738     5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  87 IGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSEsVPAQERGKAVVLLESFWAVGWLLSALISYFVI-----PTY 161
Cdd:COG0738    85 LGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLIllglsLSW 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 162 GWQTALLLAAIPALYALYLRWGLPDsprftSARKEETVWDNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMV 241
Cdd:COG0738   164 HLPYLILAVLLLLLALLFLRSKLPE-----IEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLK 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 242 -MKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWG 320
Cdd:COG0738   239 dVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFP 318
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011946562 321 ALYAYTPELYPTSiRGTGAGMAASFGRIGGILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVWVLGKETKQQ 395
Cdd:COG0738   319 TIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLAD-AFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
Sugar_tr pfam00083
Sugar (and other) transporter;
46-397 2.66e-28

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 115.45  E-value: 2.66e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  46 QMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVL---RFLIGMGLGGELPVASTL 122
Cdd:pfam00083  47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVGGASVLAPMY 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 123 VSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTY---GWQTALLLAAIPALYALYLRWGLPDSPRF--------- 190
Cdd:pfam00083 127 ISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSnsdGWRIPLGLQLVPALLLIIGLLFLPESPRWlvekgrlee 206
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 191 --TSARKEETVWDNIVKV---------------------WSS-SYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMK-GF 245
Cdd:pfam00083 207 arEVLAKLRGVPDVDRELdeikdsleagqeaekaswkelFSTkTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENlGL 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 246 SliKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFG--------NADSLALLMTFGILL--SFFN 315
Cdd:pfam00083 287 S--DSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFVILGivallgvsKSDWAGIVAIVFIALfiAFFA 364
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 316 LGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVWVLGKETKQQ 395
Cdd:pfam00083 365 MGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITD-AIGLGYTFFIFAGLLVLFIIFVFFFVPETKGR 443

                  ..
gi 1011946562 396 EL 397
Cdd:pfam00083 444 TL 445
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
14-386 1.08e-27

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 112.66  E-value: 1.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  14 VAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSA 93
Cdd:cd17359     5 VAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  94 LTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTY--------GWQT 165
Cdd:cd17359    85 FSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGgadwlgaeGWRW 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 166 ALLLAAIPALYALYLRWGLPDSPRFTSARKEETVWDNIvkvwsssyrketfMLWVL-WFC---VVFsYYGmflwlPSVMV 241
Cdd:cd17359   165 MLGLEAIPAILFLLGMLFIPESPRWLVSKGKPILIIGI-------------GLAIFqQFVginVIF-YYG-----PEIFQ 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 242 MKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVS-------AYFFGNADSLALLMTFGILL--S 312
Cdd:cd17359   226 NAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISllligtaFYFAPGSQASGIVALVLILLfvA 305
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011946562 313 FFNlGAWGAL-YAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVW 386
Cdd:cd17359   306 FFA-MSWGPVtWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLA-AFGLAFTFLIFAVICVLAFLFVW 378
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
26-396 7.35e-26

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 107.65  E-value: 7.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  26 VGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLR 105
Cdd:COG2807    34 ITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGT 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 106 FLIGMGLGGELPVASTLVSESVPAQeRGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRWglp 185
Cdd:COG2807   114 ALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWL--- 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 186 dsPRFTSARKEETVWDNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGY 265
Cdd:COG2807   190 --PLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGS 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 266 FSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTS-IRGTGAGMAAS 344
Cdd:COG2807   268 LLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPaEAAALSGMAQS 347
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1011946562 345 FGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVWVLGKETKQQE 396
Cdd:COG2807   348 VGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPYVEDA 399
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
52-356 3.77e-25

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 104.68  E-value: 3.77e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  52 SINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQE 131
Cdd:cd17374    42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRH 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 132 RGKAVVLLESFWAVGWLLSALISYfVIPTygWQTALLLAAIPALYALYLRWGLPdsprftsarkeetvwdnivkvwsssy 211
Cdd:cd17374   122 RALAITLTSCFFSIGQMLLAGLAY-AIRD--WRLLQLVVSVPFFLFFLYSWWLP-------------------------- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 212 rKETFMLWVLWFCVVFSYYGMflwlpsVMVMKGFSLIKSFEYVLImTLAQLPGYFSAAWLIERAGRKFVLITYLI--GTA 289
Cdd:cd17374   173 -KRTLILSFVWFANSFSYYGL------SLDLQHLGLNVFLLQFLF-GAVEVPARCLALFLLNHMGRRISQAVLLLlaGLC 244
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011946562 290 VSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLF 356
Cdd:cd17374   245 ILANIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLI 311
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
10-397 3.77e-22

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 97.88  E-value: 3.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  10 KLLGVAGLGWMFDAMDVGMLSFIIAAL-----QKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLL 84
Cdd:TIGR00887  16 RAIVIAGVGFFTDSYDLFCISLVTKMLgyvyyHGKGPLPSSVSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELII 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  85 FSIGSGLSALTTTLTAFLVL------RFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFV- 157
Cdd:TIGR00887  96 MIIATVASGLSPGSSPKSVMatlcfwRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAMQGFGILAGAIVALIVl 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 158 --------IPTYG--------------WQTALLLAAIPALYALYLRWGLPDSPRFTS--ARKEETVWDNIVKV------- 206
Cdd:TIGR00887 176 agfkhsleAAADEasctgscvpavdymWRILIGFGAVPALLALYFRLTIPETPRYTAdvAKDVEQAASDMSAVlqvkiea 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 207 ------------------WSSSYRKetFMLW----------VLWFCVVFSYYGMFLWLPSVMVMKGFS-----------L 247
Cdd:TIGR00887 256 epdevekastavevpkasWSDFFTH--FFKWrhgkhllgtaGSWFLLDIAFYGVNLNQKVILSAIGYSppaatnnayeeL 333
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 248 IKSFEYVLIMTLA-QLPGYFSAAWLIERAGRK------FVLITYLIgtAVSAYFFGNADSLALLMTFGILLSFFNLGAWG 320
Cdd:TIGR00887 334 YKTAVGNLIIALAgTVPGYWVTVFLVDIIGRKpiqlmgFFILTVLF--FVLGFAYNHLSTHGFLAIYVLAQFFANFGPNA 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 321 ALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNR---------HITITTIFLIFCISIFIGVIAVwVLGKE 391
Cdd:TIGR00887 412 TTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQHgdptkgyptGIWMGHVLEIFALFMFLGILFT-LLIPE 490

                  ....*.
gi 1011946562 392 TKQQEL 397
Cdd:TIGR00887 491 TKGKSL 496
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
60-387 4.38e-22

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 96.83  E-value: 4.38e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  60 VGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTL--------TAFLVLRFLIGMGLGGELPVASTLVSESVPAQE 131
Cdd:cd17369    59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYaqigilapILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKR 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 132 RGKAVVLLESFWAVGWLLSALIsyFVIPT----------YGWQTALLLAAIPALYALYLRWGLPDSPRFTSAR-KEETVW 200
Cdd:cd17369   139 RGFYGSFPQLGAPVGLLLATGV--FLLLSallsdeaflsWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKeAGQVVR 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 201 DNIVKVWSSSYRkeTFMLWVLWFCVVFSYYGMFL-WLPSVMV-MKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRK 278
Cdd:cd17369   217 APLVEVLRRHWR--ALLLAIGLRLAENVLFYLFTtFALSYATqTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRR 294
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 279 FVLITYLIGTAVSAYFF----GNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRI-GGILG 353
Cdd:cd17369   295 PVYLAGALLAALFAFPFfwllDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAIlGGGFA 374
                         330       340       350
                  ....*....|....*....|....*....|....
gi 1011946562 354 PLFVGYLVNRHITITTIFLIFCISIFIGVIAVWV 387
Cdd:cd17369   375 PLIATALVAATGSWWPVALYLAALAVISLVAALF 408
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
24-386 3.04e-21

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 94.17  E-value: 3.04e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  24 MDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLV 103
Cdd:cd17474    13 LGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 104 LRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFvIPTYGWQTALLLAAIPALYALYLRWG 183
Cdd:cd17474    93 GRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL-LAAISWRYPFFLLAALIPVAFLAILF 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 184 LPDSPRftsaRKEETVWDNIVKVWSSSYRKETFM-LWVLWFCVVFSYYGMFLWLPSVMVMK-GFSLIKSFEYVLIMTLAQ 261
Cdd:cd17474   172 LLPEPK----EKAKSSSATKLRDLKKALRGRGLLtFLVSAFLYFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLL 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 262 LPG-YFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAG 340
Cdd:cd17474   248 ALGsLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASS 327
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1011946562 341 MAASFGRIGGILGPLFVGYLVnRHITITTIFLIFCISIFIGVIAVW 386
Cdd:cd17474   328 LYNFVRFLGQAVGPLLFGLLL-EIFGLSAPFLVGAAIALAAAVLLA 372
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
32-386 7.21e-21

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 93.00  E-value: 7.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  32 IIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMG 111
Cdd:cd17324    21 LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLA 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 112 LGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTA-LLLAAIPALYALYLRWGLPDSPRF 190
Cdd:cd17324   101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAfLAIAVLALLAALLLWRLLPSLPPK 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 191 TSarkeeTVWDNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMV-MKGFSLIKSFEYVLIMTLAQLPGYFSAA 269
Cdd:cd17324   181 KP-----GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTdVPGFSSSAIIGLLLLFGVAGVVGSPLAG 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 270 WLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSiRGTGAGMAASFGRIG 349
Cdd:cd17324   256 RLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLG 334
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1011946562 350 GILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVW 386
Cdd:cd17324   335 GALGAALGGLVLD-HGGWAGVGWVGAALLLLALLLAL 370
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
17-353 1.71e-20

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 91.85  E-value: 1.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  17 LGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTT 96
Cdd:cd17321     3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  97 TLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALY 176
Cdd:cd17321    83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 177 ALYLrwglpdSPRFTSArkeetvwdnivkvwsssyrkeTFMLwvlwFCVVFSYYGMFLWLPSVM-VMKGFSLIKSFEYVL 255
Cdd:cd17321   163 ALLL------ARTFSGA---------------------VLAA----FLLGAALGGLLFLLPLYLqGVLGYSPLQAGLALL 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 256 IMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVS--AYFFGNADSLALLMTFGILLSFFNLG-AWGALYAYTPELYPT 332
Cdd:cd17321   212 PLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGllLLALLGADSSVWLLLPGLVLLGLGLGlFATPLTNAALSSVPK 291
                         330       340
                  ....*....|....*....|.
gi 1011946562 333 SIRGTGAGMAASFGRIGGILG 353
Cdd:cd17321   292 EKAGAASGILNTARQLGGALG 312
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
14-344 1.77e-20

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 91.87  E-value: 1.77e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  14 VAGLGWMFDAMDVGMLSFIIAALQKDWN--LSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGL 91
Cdd:cd17315     1 VAALGGLLFGYDLGVINGALLYIAKDLGfgLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  92 SALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFV--IPTYGWQTALLL 169
Cdd:cd17315    81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALslSPPGWWRLMFAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 170 AAIPALYALYLRWGLPDSPRFTSArkeetvwdnivkvwsssyrketfmlwVLWFCV-------VFSYYGmflwlPSVMVM 242
Cdd:cd17315   161 AAVPALLQLLLMFFLPESRALLVG--------------------------VGLQLLqqltginAVMYYA-----PTIFKS 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 243 KGfSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVS-------AYFFGNADSLALLMTFGILL--SF 313
Cdd:cd17315   210 AG-GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASllllaiaFLLPALAKAAGWLALLGILLyiAA 288
                         330       340       350
                  ....*....|....*....|....*....|.
gi 1011946562 314 FNLGAWGALYAYTPELYPTSIRGTGAGMAAS 344
Cdd:cd17315   289 FAMGAGPVPWLLLSEIFPLRIRGKGMAIATL 319
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
18-355 1.98e-20

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 91.33  E-value: 1.98e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  18 GWMFDAmdvgmlSFIIAALQKDWNLSVEQMGW---IGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSAL 94
Cdd:cd17447    11 GWVYDH------STFSSTIATEWDLVCDRKGLnqaTATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  95 TTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFViptYGWQTALLLAAIPA 174
Cdd:cd17447    85 SVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLI---RDWRWLILAVTLPC 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 175 LYALYLRWGLPdsprftsarkeetvwdnivkvwsssyrKETFMLWVLWFCVVFSYYGMflwlpsVMVMKGFSLiKSFEYV 254
Cdd:cd17447   162 APGIITWWWVP---------------------------KISLCTGIVWFGVAFTYYGI------SFNISGFGL-NVYLTQ 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 255 LIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVS--AYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPT 332
Cdd:cd17447   208 FIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSigINILIPSEFTVVRTVIAVLGKGFSEAAFTTVFLYTSELYPT 287
                         330       340
                  ....*....|....*....|...
gi 1011946562 333 SIRGTGAGMAASFGRIGGILGPL 355
Cdd:cd17447   288 VLRQNGMGYTSFIARLGGSLAPL 310
PRK03893 PRK03893
putative sialic acid transporter; Provisional
3-383 1.27e-19

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 90.53  E-value: 1.27e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   3 QQTISQRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITL 82
Cdd:PRK03893   13 HLNRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISI 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  83 LLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYG 162
Cdd:PRK03893   93 VLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWG 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 163 WQTALLLAAIPALYALYLRWGLPDSPRFTSARKEETVWDNIVKVWSSSYRK------ETFMLWVLWFCVVF-SYYGMFLW 235
Cdd:PRK03893  173 WRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKAPVRTMVDILYRGEHRiinillTLAAAAALWFCFAGnLQNAAIVA 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 236 LPSVMVMKGF-SLIKSFE------YVLIM------------TLAQLP---------------------------GYFSAA 269
Cdd:PRK03893  253 VLGLLCAAIFiSFMVQSSgkrwptGVMLMvvvlfaflyswpIQALLPtylktdlgydphtvanvlffsgfgaavGCCVGG 332
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 270 WLIERAG-RKFVLITYLIGTA-VSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGR 347
Cdd:PRK03893  333 FLGDWLGtRKAYVCSLLISQLlIIPVFAIGGANVWVLGLLLFFQQMLGQGISGLLPKLIGGYFDTEQRAAGLGFTYNVGA 412
                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1011946562 348 IGGILGPlFVGYLVNRHITITTIFLIFCISIFIGVI 383
Cdd:PRK03893  413 LGGALAP-ILGALIAQRLDLGTALASLSFSLTFVVI 447
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
26-393 2.39e-19

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 89.17  E-value: 2.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  26 VGMLSFIIAALQKDW----NLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAF 101
Cdd:cd17358    18 VGWSSPALPSLMSDNslslPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWML 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 102 LVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFViptyGWQTALLLAAIPALYALYLR 181
Cdd:cd17358    98 YLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL----PWRTLALIGAIPPVVFLILL 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 182 WGLPDSPRF-------TSARK-------------------EETVWDNIVKVWSSS--------YRKETFMLWVLWFCVVF 227
Cdd:cd17358   174 FFIPESPRWlakkgreEEAEKslqflrgkdadiskeaaeiQEELAELEKEAKESSfsdlfqrkYLKPLVIGLGLMLFQQL 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 228 SYYGMFLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVS----AYFFGNADSLAL 303
Cdd:cd17358   254 SGINAVIFYASSIFDEAGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGllalGLYFYLQEHGAL 333
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 304 LMTFGIL--------LSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNrHITITTIFLIFC 375
Cdd:cd17358   334 LSSVSWLplvglviyIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTL-AWGASGTFWIFA 412
                         410
                  ....*....|....*...
gi 1011946562 376 ISIFIGVIAVWVLGKETK 393
Cdd:cd17358   413 GICGLALVFVLLFVPETK 430
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
48-389 3.06e-19

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 88.40  E-value: 3.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  48 GWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESV 127
Cdd:cd17473    38 PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYF 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 128 PAQERGKAVVLLESFWAVGWLLSALISYFVIpTYGWQTALLLAAIPALYALYLRWGLPDsprftSARKEETVWDNIVKVW 207
Cdd:cd17473   118 EGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLLFLPE-----PARKSKSAASPGAATA 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 208 SSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVL-IMTLAQLPGYFSAAWLIERAGRKFVLITYLI 286
Cdd:cd17473   192 AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALaIASLAGAIGALLFGRLKRRLGKRRLLAIGFA 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 287 GTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHIT 366
Cdd:cd17473   272 LMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGG 351
                         330       340
                  ....*....|....*....|...
gi 1011946562 367 ITTIFLIFCISIFIGVIAVWVLG 389
Cdd:cd17473   352 LSGAFLILGVLALVLAIVLLLLR 374
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
12-385 1.75e-18

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 86.09  E-value: 1.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  12 LGVAGLGWMFDAMdvgMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGL 91
Cdd:cd17504     1 LALAALAVMLVET---MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  92 SALTTTLTAFLVLRFLIGMGlGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAA 171
Cdd:cd17504    78 AAFAPNLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 172 IPALYALYLrwgLPDSPRFTSArkeetvwdnivkvwsssyRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMK-----GFS 246
Cdd:cd17504   157 PVAVLLAAL---VPLIDLRLLR------------------RRNVLLANITALLAGFGMFMVFQLLPQLLQLPtptgfGLG 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 247 LIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFG-NADSLALLMTFGILLSFFNLGAWGALYAY 325
Cdd:cd17504   216 ITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLAlLHSSLWALVVALLLIGIGLGLAFASLPNI 295
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1011946562 326 TPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITITTIF---------LIFCISIFIGVIAV 385
Cdd:cd17504   296 VVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGgvptegayvLAFLIGAALALAAL 364
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
57-377 2.22e-18

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 85.60  E-value: 2.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  57 GMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAV 136
Cdd:cd17377    51 GVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECVGKSYWALAG 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 137 VLLESFWAVGWLLSALISYFVIPtygWQTALLLAAIPALYALYLRWGLPdsprftsarkeetvWDNIVKVWsssyrketf 216
Cdd:cd17377   131 SLGGLFFAVGIAQYALLGYFIRS---WRTLAVVVNLQGTLVFLLSLFIP--------------GRTLILMY--------- 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 217 mlwvLWFCVVFSYYGMFLwlpSVMVMKGfsliKSFEYVLIMTLAQLPGYFSAAWLIE--RAGRKFVLITYLIGTAVSAYF 294
Cdd:cd17377   185 ----VWFVCSLVYYGLTL---NAGDLGG----NIYLNLALSGLVELPAYPLCIYLINqkWSGRRRTLAGFLFLGGIACLL 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 295 --------------FGNADSLALLMTFGILLSFfnlgawGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPlFVGYL 360
Cdd:cd17377   254 vmfvpekkdsgvfaVVNSTSLSLLGKLTISAAF------NIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAP-FIPSL 326
                         330
                  ....*....|....*..
gi 1011946562 361 VNRHITITtiFLIFCIS 377
Cdd:cd17377   327 KSVQWSLP--FIVFGAS 341
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
52-355 2.98e-18

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 85.16  E-value: 2.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  52 SINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQE 131
Cdd:cd17446    40 SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRV 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 132 RGKAVVLLESFWAVGWLLSALISYfVIPTYGWQTALLLAaipalyalylrwglpdsPRFtsarkeetvwdnIVKVWSSSY 211
Cdd:cd17446   120 RAVVGTLLGYCYTLGQLILAGVAY-AIRDWRWLQLAVSL-----------------PFF------------IFFLYSWWF 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 212 RKETFMLWVLWFCVVFSYYGMflwlpsVMVMKGFSlIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLI--GTA 289
Cdd:cd17446   170 PRITFCLSLVWFSTSFAYYGL------AMDLQKFG-VSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALIlaGIM 242
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1011946562 290 VSAYFFGNAD------SLALLMTfGILLSFFNlgawgALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPL 355
Cdd:cd17446   243 ILANIFVPQDlqtvrtALAVFGK-GCLAASFN-----CVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPL 308
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
22-388 3.94e-18

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 85.24  E-value: 3.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  22 DAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAF 101
Cdd:cd17442    13 EAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWF 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 102 LVLRFLIGMGLGGElPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWqtalllaaipalyalylR 181
Cdd:cd17442    93 VFLRCMVGCGVSGH-SQGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGW-----------------R 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 182 WGLpdspRFTSarkeetVWDNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLW-------------LPSVMVMKGFSlI 248
Cdd:cd17442   155 WLI----RFAS------IPGIILIVVFKFIPRTTLQIWVIWLGISFAYYGVILAssellernllcgsDPSDEEAGIKH-I 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 249 KS-------------FEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFN 315
Cdd:cd17442   224 ESespcychmfnpsdYQTMIISTLGEIALNPLNILGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGLTIFLFMLRALV 303
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011946562 316 LGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNrhITITTIFLIFCISIFIGVIAVWVL 388
Cdd:cd17442   304 SANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMS--ASVLGALCLFSSVCIVCAISAFTL 374
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
39-385 1.44e-15

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 77.10  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  39 DWNLSVEQMgW----IGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGG 114
Cdd:cd17375    26 DWDLVCDRE-WlaklIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSG 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 115 ELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFViptYGWQTALLLAAIPALYALYLRWGLPdsprftsar 194
Cdd:cd17375   105 YLVVVFVYVTEFTGIKARTWASMHVHAFFAVGIMVVALVGYLV---RTWWIYQIILSLVTIPFILCCWMLP--------- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 195 keetvwdnivkvwsssyrKETFMLWVLWFCVVFSYYGMFLwlpSVMVMKGfsliKSFEYVLIMTLAQLPGYFSAAWLIER 274
Cdd:cd17375   173 ------------------KRTITVWLIWFTGSLGYYVFSL---GSVNLGG----NEYLNLFLVGAVEIPSYIIACIGMDK 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 275 AGRKFVLITYLIGTAVSAYF--FGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGIL 352
Cdd:cd17375   228 LGRRNTLAPFLLLSALACMLimVIPQDYEVLTIVLSMTGKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVV 307
                         330       340       350
                  ....*....|....*....|....*....|...
gi 1011946562 353 GPlFVGYLvnrhititTIFLIFCISIFIGVIAV 385
Cdd:cd17375   308 AP-FCVYL--------SDVWIFLPQLLVGIMAF 331
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
16-388 1.51e-15

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 77.23  E-value: 1.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  16 GLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALT 95
Cdd:cd17320     5 ALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  96 TTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTA-LLLAAIPA 174
Cdd:cd17320    85 SSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIfVFLALLGL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 175 LYALYLRWGLPDS-PRFTSARKEETVWDNIVKVWSSSyrkeTFMLWVLwfCVVFSYYGMFLWLPS--VMVMKGFSLikSF 251
Cdd:cd17320   165 LLLLLVLLFLPETlPEEKRKPLLSSLLRAYKRVLKNR----RFLGYAL--ALGLSFAGLFAYLAAapFIYIEQLGL--SP 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 252 EYVLIMTLAQLPGYFSAAWLIERAGRKF---------VLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGAL 322
Cdd:cd17320   237 AQFGLLFALNAIALILGSLLNGRLVRRFgprrllrlgLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNA 316
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011946562 323 YAYTPELYPtSIRGTGAGMAASFGRIGGILGPLFVGYLVNrhITITTIFLIFCISIFIGVIAVWVL 388
Cdd:cd17320   317 TSLALEPFP-HVAGTASALLGFLQFLIGALAGALVGLLPN--GTALPMGLLILVLGLLALLLLILL 379
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
43-388 1.55e-15

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 76.83  E-value: 1.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  43 SVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTL 122
Cdd:cd17502    28 GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFII 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 123 VSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWqtalllaaipalyalylRWGLpdsprftsarkeetvWDN 202
Cdd:cd17502   108 IADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSW-----------------RWCF---------------YIN 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 203 I-VKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMV-MKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGR--K 278
Cdd:cd17502   156 LpIGGLALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQlVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRykP 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 279 FVLITYLIGTAVSA--YFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGplf 356
Cdd:cd17502   236 LIVIGTILMSVGAGllTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLG--- 312
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1011946562 357 vgylvnrhITITTIFLIFCISIFIGVIAVWVL 388
Cdd:cd17502   313 --------VAITDVFLVALALAALAFLLSLFL 336
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
60-388 1.79e-15

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 77.41  E-value: 1.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  60 VGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTL-------TAFLVL-RFLIGMGLGGELPVASTLVSESVPAQE 131
Cdd:cd17368    55 IGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYatigiaaPLLVLLaRLLQGFAAGGEVGGVTAYLVEAAPPGR 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 132 RG------KAVVLLESFWA--VGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRWGLPDSPRFTSARKEETVwDNI 203
Cdd:cd17368   135 RGfytswqSASQQVAIVAGalVGYLLSLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTR-REL 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 204 VKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLIT 283
Cdd:cd17368   214 FALLANNRRIILLGMLLVAGSTVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLV 293
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 284 YLIGTAVSAY----FFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFG-RIGGILGPLFVG 358
Cdd:cd17368   294 ITLAALVTLYpvfaWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAvAIFGGFAQFIVT 373
                         330       340       350
                  ....*....|....*....|....*....|
gi 1011946562 359 YLVNRHITITTIFLIFCISIFIGVIAVWVL 388
Cdd:cd17368   374 WLIELTGSPLAPAWYLMGAALLGLLATLML 403
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
29-363 2.00e-15

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 77.03  E-value: 2.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  29 LSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLI 108
Cdd:TIGR00881  14 FALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALN 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 109 GMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYG---WQTALLLAAIPALYALYLRWGLP 185
Cdd:TIGR00881  94 GIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYswhWVFIVPGIIAIIVSLICFLLLRD 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 186 D--SPRFTSARKE--ETVWDNIVKVWSSSYRKETFM--------LWVLWFCVVFSY---YGMFLWLPSVMV-MKGFSLIK 249
Cdd:TIGR00881 174 SpqSCGLPPAEEMpnEEPDGDAEKKEEELTKKQIFLqyvllnkvLWYISLGYVFVYvvrTGILDWSPLYLTqEKGFSKEK 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 250 SFEYVLIMTLAQLPGYFSAAWLIER--AGRKFVL---ITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYA 324
Cdd:TIGR00881 254 ASWAFTLYELGGLVGTLLAGWLSDKlfNGRRGPLavfFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGV 333
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1011946562 325 YTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNR 363
Cdd:TIGR00881 334 IASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADG 372
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
18-383 2.24e-15

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 76.74  E-value: 2.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  18 GWMFDAmdvgmlSFIIAALQKDWNLSVEQmGWIGSINS----IGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSA 93
Cdd:cd17376    11 GWEYSQ------DVYLSTIVTEWNLVCED-DWKVPLTTslffVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQI 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  94 LTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVpaqerGKAVVLLES------FWAVGWLLSALISYFViptYGWQTAL 167
Cdd:cd17376    84 FSPSWEMFTVLFVIVGMGQISNYVVAFVLGTEIL-----GKSVRILFStlgvciFYAIGYMLLPLFAYFI---RDWRMLL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 168 LLAAIPALYALYLRWGLPDSprftsarkeetvwdnivkvwsssyrkeTFMLWVLWFCVVFSYYGMFLWLPSvmvMKGFSL 247
Cdd:cd17376   156 LALTLPGVLCVPLWWFIPIT---------------------------TIMSLLLWMAISVGYFGLSLNTPN---LHGDPY 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 248 IKSFEYVLImtlaQLPGYFSAAWLIERAGRKFVLITYL-IGTAVSAYFFGNADSLALLMTFGILLSFFNL-GAWGALYAY 325
Cdd:cd17376   206 LNCFLSAVI----EVPAYIIAWLLLRSLPRRYSIAATLvLGGGVLLFIQLVPTDLQVLATALVMLGKFGItAAFSMVYVY 281
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 326 TPELYPTSIRGTGAGMAASFGRIGGILGPLFVgYL--VNRHItitTIFLIFCISIFIGVI 383
Cdd:cd17376   282 TAELYPTVVRNMGVGVCSTASRIGSIISPYFV-YLgaYDRYL---PYILMGSLTVLIGIL 337
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
26-397 3.14e-15

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 76.52  E-value: 3.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  26 VGMLSFI--IAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLV 103
Cdd:cd17356    24 LNMKSFQkyFADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYQLI 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 104 L-RFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYG---WQTALLLAAIPALYALY 179
Cdd:cd17356   104 VgRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDGsaqWRIPLGLQIVWGLLLLI 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 180 LRWGLPDSPRFtsarkeetVWDNIVKVwsssyrkeTFMLWVLWF-CVVFSYYGmflwlPSVMVMKGFSLIKSFEYVLIMT 258
Cdd:cd17356   184 GMFFLPESPRW--------LYRTILGI--------MLQLFQQLTgINYFFYYG-----TTIFQSTGLTGSSPLLTSIILY 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 259 LAQLPGYFSAAWLIERAGRKFVLItyLIGTAVSAYFFGNADSLAL------------------LMTFGILLSFFNLGAWG 320
Cdd:cd17356   243 IVNFVSTIPGLFFVDKFGRRTCLL--IGAAGMSICLFIYAAVGVRylipnpqsgtsnksagngMIVFICLFIFSFATTWG 320
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1011946562 321 AL-YAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITitTIFLIFCISIFIGVIAVWVLGKETKQQEL 397
Cdd:cd17356   321 PIaWVYVAEVFPLRVRSKGMALATAFNWLWNFLISFFTPFIIGSIGF--KYYYIFAGCNLLAFIVVFFFVPETKGLTL 396
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
25-397 1.00e-14

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 75.13  E-value: 1.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  25 DVGMLSFIIAALQKDWNLSVEQMG-WIGSINSIGMaVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLV 103
Cdd:cd17437    12 DIGVMSGAVIFIKEDLKISDVQEEvLIGSLNIISL-VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMV 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 104 LRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFV--IPTY-GWQTALLLAAIPALYALYL 180
Cdd:cd17437    91 GRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFsgLPLHvGWRLMLGVGAVPSLFLAIG 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 181 RWGLPDSPRftsarkeetvwdnivkvWSSSYRKETFM-LWVLWFCVVFSYYGMFLWLPSVMVMKGfslIKSFEYVLIMTL 259
Cdd:cd17437   171 VLAMPESPR-----------------WTPAVRRMLIAaLGIHFFQQASGIDAVVLYSPRIFKKAG---IKSKDKLLLATV 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 260 A----QLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFG--------NADSLALLMTFGIL-----LSFFNLGAWGAL 322
Cdd:cd17437   231 AvgvtKTLFILVATFLLDKVGRRPLLLTSTGGMTLSLTALAtsltfidrNGGGLTWALVLAITavcsfVAFFSIGAGPIT 310
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011946562 323 YAYTPELYPTSIRGTGAGMAASFGRI-GGILGPLFVGylVNRHITITTIFLIFCISIFIGVIAVWVLGKETKQQEL 397
Cdd:cd17437   311 WVYSSEIFPLRLRAQGASLGVVVNRLmSGTVSMTFLS--MSKAITTGGTFFLFAGVAAAAWVFFYFFLPETKGKSL 384
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
27-389 1.13e-14

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 74.55  E-value: 1.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  27 GMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRF 106
Cdd:cd17489    13 YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 107 LIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRWGLPD 186
Cdd:cd17489    93 IHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKD 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 187 SPRFTSARKEETVWdnivkVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFeyVLIMTLAQLPGYF 266
Cdd:cd17489   173 PPPVAAEEAEAGTR-----AFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLF--FTVYAIALLLSRP 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 267 SAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFG 346
Cdd:cd17489   246 FSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFF 325
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1011946562 347 RIGGILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVWVLG 389
Cdd:cd17489   326 DLGIGLGGLLLGLVAE-LFGYRAMFLLAAVVVLLALVLYIFLL 367
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
23-374 1.34e-14

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 74.67  E-value: 1.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  23 AMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFL 102
Cdd:cd17333     9 GLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 103 VLRFLIGMGLGGELPVASTLVSESVPaQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRW 182
Cdd:cd17333    89 VLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILI 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 183 GLPDSPRFTSARKEETVWDNIVKVWSSSYR-KETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVL-IMTLA 260
Cdd:cd17333   168 LLTLFPELPSARNPQQSVGAFSASASRLLRnPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLsGFWVG 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 261 QLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSiRGTGAG 340
Cdd:cd17333   248 ITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYA-KGKGTS 326
                         330       340       350
                  ....*....|....*....|....*....|....
gi 1011946562 341 MAASFGRIGGILGPLFVGYLVnRHITITTIFLIF 374
Cdd:cd17333   327 VLLAAGSIGGAIIPFIMGFIA-EAVGIQTAMLLI 359
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
36-386 2.30e-14

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 73.81  E-value: 2.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  36 LQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGE 115
Cdd:cd17475    22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 116 LPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRW-GLPDSPRF-TSA 193
Cdd:cd17475   102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWlFYREPPAAsAAT 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 194 RKEETVWDNIvkvwsSSYRKETFMLWVLWFCV--VFSYYGM-FLWLPSVMVMKGFSLIKSfeyVLIMTLAQLPGYFSAAW 270
Cdd:cd17475   182 ESASTLLRSL-----KEVLRNRDVWLIAIAGAllVAPQFALlTFLLLFLHDHLGLSVVAA---GALLAVAQLGGALGRIG 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 271 L-------IERAGRKFVLITYLIGTAVSAYFFGNADS--LALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGM 341
Cdd:cd17475   254 LgrvsdrvFGGRRRPVLVITAAIAAAALLVLSLLSPGtpLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGL 333
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1011946562 342 AASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVW 386
Cdd:cd17475   334 ANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
46-397 3.28e-14

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 73.91  E-value: 3.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  46 QMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVL---RFLIGMGLGGELPVASTL 122
Cdd:TIGR00879  72 LWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAFALSVEMLivgRVLLGIGVGIASALVPMY 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 123 VSESVPAQERGKAVVLLESFWAVGWLLSALISY---FVIPTYGWQTALLLAAIPALYALYLRWGLPDSPRF-------TS 192
Cdd:TIGR00879 152 LSEIAPKALRGALTSLYQLAITFGILVAYGFGSgkvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWlvgkgrvEE 231
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 193 ARK-----------------EETVWD--------NIVKVWSSSYRKETFMLWVL-------WF-----CVVFSYYGmflw 235
Cdd:TIGR00879 232 ARKslarlrgtsgedkelldELELIDikrsiekrSVQPSWGSLFSSTRRIRRRLflgvvlqWFqqftgINAIMYYS---- 307
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 236 lPSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFG---------NADSLALLMT 306
Cdd:TIGR00879 308 -PTIFENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGilgasfvtgSSKSSGNVAI 386
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 307 FGILL--SFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIA 384
Cdd:TIGR00879 387 VFILLfiAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFV 466
                         410
                  ....*....|...
gi 1011946562 385 VWVLgKETKQQEL 397
Cdd:TIGR00879 467 YFFL-PETKGRTL 478
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
27-386 3.50e-14

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 73.36  E-value: 3.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  27 GMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRF 106
Cdd:cd17478    13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 107 LIGMGLGGELPVASTLVSESVPAQeRGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRWGLPD 186
Cdd:cd17478    93 LAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 187 SPRFTSARKEETVwdnIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGYF 266
Cdd:cd17478   172 LKKPEAKKAAAKS---SARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTL 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 267 SAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFgILLSFFNLGAWGALYAYTPELYPTSiRGTGAGMAASFG 346
Cdd:cd17478   249 IGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLPGN-VGLASGLMMGLS 326
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1011946562 347 RIGGILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVW 386
Cdd:cd17478   327 FGLGGIGAPVLGALAD-AFGLESVLLILALLPLLGALLAF 365
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
14-388 3.61e-14

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 73.07  E-value: 3.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  14 VAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGW---IGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSG 90
Cdd:cd17360     1 FAGIGGFLFGYDTGVISGALLYIKDDLGEVVLSTGWqelIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  91 LSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALI-SYFVIPTYGWQTALLL 169
Cdd:cd17360    81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVInGAFSYLPGGWRWMLGL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 170 AAIPALYALYLRWGLPDSPRFTSARKEETVwdnivkvwsssyrkETFMLWVLWFCVV--FSYYGmflwlPSVMVMKGF-S 246
Cdd:cd17360   161 AAVPAVLQFIGLLFLPESPRWPSTRRALIV--------------GCGLQAFQQFSGIntVMYYS-----ATILQMAGFkD 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 247 LIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGnadSLALLMTFGILLSFFNLGAWGALYAYT 326
Cdd:cd17360   222 NQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVALVVLA---VWLALVGLILYLAFFAPGMGPVPWTVN 298
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1011946562 327 PELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVWVL 388
Cdd:cd17360   299 SEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQ-AIGPYGTFLLFAGLAVLGLIFIYFC 359
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
52-362 3.76e-14

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 72.77  E-value: 3.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  52 SINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQE 131
Cdd:cd17379    40 SSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 132 RGKAVVLLESFWAVGWLLSALISYFvIPTYGWQTALLLAAIPALYALYlrWGLPdsprftsarkeetvwdnivkvwsssy 211
Cdd:cd17379   120 RRTVGIVYQMFFTLGLLILPGIAYF-IPHWRWLQLAVTLPNFLFLLYY--WFIP-------------------------- 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 212 rKETFMLWVLWFCVVFSYYGMFLWLPSVmvmkGFSLIKSFeyvLIMTLAQLPGYFSAAWLIERAGRK--FVLITYLIGTA 289
Cdd:cd17379   171 -KHTFILMYAWFTSAVVYQGLIMRLGIT----GGNLYLDF---FISALVELPAAFIILLTIDRIGRRlpFAASNIVAGAA 242
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011946562 290 VSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVN 362
Cdd:cd17379   243 CLITAFIPPDLHWLKTTIACVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLYRLAE 315
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
56-357 3.90e-14

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 72.78  E-value: 3.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  56 IGMAVGALLFGLLAD-RIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGK 134
Cdd:cd17378    44 VGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPKWRGQ 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 135 AVVLLESFWAVGWLLSALISYFVIPTygWQTALLLAAIPALYalYLRWGLPDSPRFTsarkeetvwdnivkvwsssyrke 214
Cdd:cd17378   124 VGMSTFFFFVLGFMSLPGIAYLNGSS--WRVLYFWTSIPALI--YCILVYLFARRLL----------------------- 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 215 tfMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSliksfeyVLIMTLAQLPGYFSAAWLIERAGRKFVLI--TYLIGTAVSA 292
Cdd:cd17378   177 --AVMVIGFGIGMVYYGIPLAVGNLKFNIYLS-------VALNALSELPAFVITAFLLDRFGRRPSLLgfTLLSGASCLL 247
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011946562 293 YFF-GNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFV 357
Cdd:cd17378   248 CFVlSIGGTTSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIV 313
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
41-398 5.94e-14

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 72.77  E-value: 5.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  41 NLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVAS 120
Cdd:cd17362    35 NLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAP 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 121 TLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTY-GWQTALLLAAIPALYALYLRWGLPDSPRftsarkeetv 199
Cdd:cd17362   115 VYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVgGWRYMYGLAAPPALLLGIGMWFLPPSPR---------- 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 200 wdnivkvWSSSYRKETFM-LWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYV-LIMTLAQLPGYFSAAWLIERAGR 277
Cdd:cd17362   185 -------WQGNYRKPLIIgLGLVLFQQITGQPSVLYYAATIFKSAGFSAASDATLVsVGLGVFKLLMTIVAVLLVDKLGR 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 278 KFVLIT-------YLIGTAVSAYFFGNADSLALLMTFGILL---SFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGR 347
Cdd:cd17362   258 RPLLLGgvsgmvvSLFLLAAYNLFVQMGPAGLAWLSLVALLlyvGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNF 337
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1011946562 348 IGGILGPLFVGyLVNRHITITTIFLIFCISIFIGVIAVWVLGKETKQQELA 398
Cdd:cd17362   338 GSNALVSLAFL-PLQELIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSLE 387
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
29-388 6.16e-14

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 72.31  E-value: 6.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  29 LSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLI 108
Cdd:cd17312    22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 109 GMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLA-AIPALYALYLRWGLPDS 187
Cdd:cd17312   102 GLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPgIVGLVVAIILFFFLRDS 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 188 PRFtsarkeetvwdnivkvwsssyrketfmLWVLWFCVVFSY---YGMFLWLPSVMV-MKGFSLIKSFEYVLIMTLAQLP 263
Cdd:cd17312   182 PPY---------------------------VWVLSLAYAFVYivrYACLDWGPLYLYeVKGYSLIDAGWFSSLYEVGGIA 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 264 GYFSAAWLIERAG---RKFVLITYLIGTAVSAY-FFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTS-IRGTG 338
Cdd:cd17312   235 GTILAGLLSDKLFggrRAPIAVIYMLLMTLSLAlFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKeAAGTA 314
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1011946562 339 AGMAASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVWVL 388
Cdd:cd17312   315 TGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
60-345 1.47e-13

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 71.56  E-value: 1.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  60 VGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTA--------FLVLRFLIGMGLGGELPVASTLVSESVPAQE 131
Cdd:cd17367    55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGR 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 132 RGKAVVLLESFWAVGWLLSALISYFVIPT--------YGWQTALLLAAIPALYALYLRWGLPDSPRF----TSARKEETV 199
Cdd:cd17367   135 RGFYSSFQYVTLIGGQLLALGVLLVLQHTlgedqmaaWGWRIPFLLGGVLAVVVLWLRRGLEETESFeaiaESNEASAGT 214
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 200 WDNIVKVWSSSyrketfmLWVLWFCVVFS--YYGMFLWLPSVMVMK-GFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAG 276
Cdd:cd17367   215 LRELRRHPREL-------LLVVGLTAGGTlaFYTWTTYLQKFLVNTaGFSKGDATWITTAALLVFMLLQPLGGRLSDRIG 287
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011946562 277 RKFVLITYLIGTAVSAYFF----GNADSLALLmTFGILLSFFNLGAWGALYA-YTPELYPTSIRGTGAGMAASF 345
Cdd:cd17367   288 RRPLLLFFGIGGTLATVPLlsalDHTDSPYTA-FALVLVGLVFLSGYTSINAvVKAELFPTHVRALGVGLPYAL 360
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
15-135 5.82e-13

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 69.53  E-value: 5.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  15 AGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSAL 94
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1011946562  95 TTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKA 135
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAA 121
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
20-387 2.07e-12

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 67.71  E-value: 2.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  20 MFDAMDVGMLSF--IIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTT 97
Cdd:cd06180     7 LAVAMGIGRFAYtpLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  98 LTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYF--VIPTYGWQTALLLAAIPAL 175
Cdd:cd06180    87 FAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAglGGGLSWRAGWLALALLSAV 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 176 YALYLRWGLPDSPR-FTSARKEETVWDNIVKVWsssyrketfMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYV 254
Cdd:cd06180   167 LLLLSFLLLRRGPSaPTEASAAESAPGLNRPLW---------RLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLW 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 255 LIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSI 334
Cdd:cd06180   238 SLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAA 317
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1011946562 335 RGTGAGMAASFGrIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVWV 387
Cdd:cd06180   318 PRALALMTASFG-VGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALL 369
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
12-360 4.76e-12

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 66.88  E-value: 4.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  12 LGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGL 91
Cdd:cd17328     1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  92 SALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALI-SYFVIPTYGWQTALLLA 170
Cdd:cd17328    81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVgGLVAQATGGWRWAFRVT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 171 -AIPALYALYLRWGLPDSPRFTSARKEE--TVWDNIVKVWSSSYRKETFMLWVLWF-CVVFSYYGMFLWLPSVMvMKGFS 246
Cdd:cd17328   161 gVLGVLLAILLLLFVREPPRGAAEGGVMakSTATSFLADLKALAKNPSFILSTLGFtAVSFVTGALAFWAPTFF-LRAFG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 247 LIK------SFEYVLIMTLAQLPGYFSAAWLIERAGRKFV---LITYLIGTAVSAYFF-----GNADSLALLMTFGILLS 312
Cdd:cd17328   240 VGDlssadvGLIFGAITCIAGVLGVLLGGILADRLRRKTPradPLVCAVGLLAAAPFLflalvLALSNLLLAWVLLFLGE 319
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1011946562 313 FFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGR-IGGILGPLFVGYL 360
Cdd:cd17328   320 FLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHlLGDAGSPYLIGLI 368
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
56-385 4.80e-12

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 66.86  E-value: 4.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  56 IGMAVG------ALL---FGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGElpVASTLVSES 126
Cdd:cd17472    34 IGLALGiygltqAIFqipFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISS--VVMALLADL 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 127 VPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTA-LLLAAIPALYALYLRWGLPDSPRFTsaRKEETVWDNIVK 205
Cdd:cd17472   112 TREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLfLITAILSLVSLLILLFFVPDPPKIV--QISEKEKKKLKK 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 206 VWSSsyrKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRK---FVLI 282
Cdd:cd17472   190 LLKN---KRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMkqvFVSS 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 283 TYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLgawgaLYAYTPELY----PTSIRGTGAGMAASFGRIGGILGPLFVG 358
Cdd:cd17472   267 ILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNL-----LEALLPSLVskiaPKEYRGTAMGIYNTSQFLGSFLGGALGG 341
                         330       340
                  ....*....|....*....|....*..
gi 1011946562 359 YLVNRHITITTIFLIFCISIFIGVIAV 385
Cdd:cd17472   342 LLWGLLGYSSVFLTILILALLWLLVSF 368
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
46-393 6.40e-12

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 66.90  E-value: 6.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  46 QMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVL---RFLIGMGLGGELPVASTL 122
Cdd:cd17357    50 LWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPELLifgRFLVGIACGLSTGFVPMY 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 123 VSESVPAQERGKAVVLLESFWAVGWLLSALISY-FVIPT-YGWQTALLLAAIPALYALYLRWGLPDSPRFT--------- 191
Cdd:cd17357   130 LQEISPSELRGALGSLTQIGVTLGILLGQVFGLpSVLGTeTLWPYLLFFPGIPALLQLAALPFFPESPKFLliskgdeee 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 192 -----------------------------SARKEETVWDnIVKvwSSSYRKETFMLWVLWFCVVFS------YYGMFLWL 236
Cdd:cd17357   210 aekslkflrgieddvdqeleeikkeseqmGDQKQVSLMQ-LLR--DPSLRLPLLLVLVVSASQQFSginaifFYSTFIFE 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 237 PSVMVMKGFSLIKSFEYVL--IMTLAqlpgyfsAAWLIERAGRKFVLITYLIGTAVSAYFFGNAD------------SLA 302
Cdd:cd17357   287 NAGFSPQLAEWANLGIGIVnvLSTIV-------GPFLIEKVGRRPLLLISLSVCAVALLLMSVFLflseqnswmsygCIV 359
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 303 LLMTFGIllsFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNrhITITTIFLIFCISIFIGV 382
Cdd:cd17357   360 AIFLFIF---FFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQS--IGGGFVFIIFAIPCALFL 434
                         410
                  ....*....|.
gi 1011946562 383 IAVWVLGKETK 393
Cdd:cd17357   435 LYLYRYLPETK 445
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
28-386 6.46e-12

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 66.48  E-value: 6.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  28 MLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFL 107
Cdd:cd17329    18 VWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVL 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 108 IGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRWGLPDS 187
Cdd:cd17329    98 TGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPET 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 188 PRFTSARKEEtvwdNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMvMKGFSLIKSFEYVLIMTLAQL---PG 264
Cdd:cd17329   178 RPKRRAAEKT----EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVY-VVEILGLGESLLGLLLALNALlivLL 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 265 YFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAAS 344
Cdd:cd17329   253 QFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYAL 332
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1011946562 345 FGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVW 386
Cdd:cd17329   333 AWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
52-388 1.28e-11

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 65.37  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  52 SINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLI-GMGLGGELPVASTLVSESVPAQ 130
Cdd:cd17355    45 TVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLgGGGAGTLAAVAFATVAAWWFER 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 131 ERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRWGLPDSPRFTSARKEETVWDNIVKVWSSS 210
Cdd:cd17355   125 RRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLK 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 211 YRKETFMLWVL---WFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIG 287
Cdd:cd17355   205 EALRSASFWLLalaFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYAL 284
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 288 TAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTP-ELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHIT 366
Cdd:cd17355   285 RALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAaRYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGS 364
                         330       340
                  ....*....|....*....|..
gi 1011946562 367 ITTIFLIFCISIFIGVIAVWVL 388
Cdd:cd17355   365 YTAAWALAVALGLIAALLVLPI 386
2_A_01_02 TIGR00880
Multidrug resistance protein;
56-163 1.95e-11

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 61.51  E-value: 1.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  56 IGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKA 135
Cdd:TIGR00880   9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVA 88
                          90       100
                  ....*....|....*....|....*...
gi 1011946562 136 VVLLESFWAVGWLLSALISYFVIPTYGW 163
Cdd:TIGR00880  89 LGLMSAGIALGPLLGPPLGGVLAQFLGW 116
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
28-386 2.97e-11

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 64.58  E-value: 2.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  28 MLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGS-GLSALTTTLTAFLVLRF 106
Cdd:cd17341    17 LFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLlALALAVSSYWGLLVLGF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 107 LIGMGlGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALI-------SYFVIPTYGWQTALLLAAIPALYALY 179
Cdd:cd17341    97 LLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLapliagaIVFDGGFVGWRNAFFVPGILLAIAAV 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 180 LRW----GLPDSPRFTSARKEEtvwdnivkVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMV-----MKGFSLIKS 250
Cdd:cd17341   176 LVLlfgdDLPTGKASALEFLKV--------QLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKtrfglPLVTAGILA 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 251 FEYVLIMTLAQ-LPGYFSAAWLIERAgRKFVLITYLIGTAVSAYF-FGNADSLALLMTFGILLSFFNLGAWGALYAYTPE 328
Cdd:cd17341   248 ALFPLAGALARpAGGWLSDRFGGRRR-LWWLFIVMTIGAALLSLSlPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVPF 326
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1011946562 329 LYPTSIrGTGAGMAASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVW 386
Cdd:cd17341   327 IFRREL-GAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVW 383
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
35-373 3.44e-11

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 64.11  E-value: 3.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  35 ALQKDWNLSveQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIgsgLSALT-----TTLTAFLVLRFLIG 109
Cdd:cd17380    26 AKEFGWSKT--DQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSL---ATLLTpllaySSLPLLILSRILLG 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 110 MGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALyalylrwglpdspr 189
Cdd:cd17380   101 LGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGL-------------- 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 190 ftsarkeetvwdnivkVWSSSYRKETFMLWVLW---FCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYV----LIMTLAQL 262
Cdd:cd17380   167 ----------------LWALVWLIYLPPVWAIIvahFCMNWGFYILLSWLPTYFHEVLVPLAKGWVFNvvpwLVMFPSSN 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 263 PGYFSAAWLIER-----AGRKFVLITYLIGTAVSAYFFGNADSLA---LLMTFGILLSFFNlgaWGALYAYTPELYPTSi 334
Cdd:cd17380   231 VAGWLADHLISRgwtvtSVRKLMQSIGFLGPALFLLLLSHTDSFSlalLCMSVALGLSAFS---SSGVLVNHQDIAPNY- 306
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1011946562 335 RGTGAGMAASFGRIGGILGPLFVGYLVNRHITITTIFLI 373
Cdd:cd17380   307 AGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVL 345
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
14-158 5.46e-11

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 64.18  E-value: 5.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  14 VAGLGWMFDAMDVGMLSFIIAALQKDWnLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSA 93
Cdd:cd06179     2 ALCLAYFAQLFGVTLPAAVLPFIVADL-GPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011946562  94 LTTTLTAFLVLRFLIGMGLGGELPVAStLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVI 158
Cdd:cd06179    81 TAKSVNMLIGGQALIGIGAGTQGLGAA-VASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALV 144
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
41-383 5.70e-11

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 63.37  E-value: 5.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  41 NLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMgLGGELPVAS 120
Cdd:cd17330    30 GASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGL-TGGNVSVAQ 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 121 TLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQ-TALLLAAIPALYALYLRWGLPDSPRFtsarkeetv 199
Cdd:cd17330   109 AYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYAlPFLVAAALALLNLVLVLFFLPPLRRL--------- 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 200 wdnivkvwsssyrketFMLWVLWFCVVFSYYGMF-LWLPSVMVMKGFSLIKSFEYV-LIMTLAQLpgyFSAAWLIERAGR 277
Cdd:cd17330   180 ----------------LLVYFLIALAFAGLESVFsLFLKDRFGFSPSQIGLLLALVgIAGILAQL---LLIPRLAKRLGE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 278 KFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFV 357
Cdd:cd17330   241 RKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLA 320
                         330       340
                  ....*....|....*....|....*.
gi 1011946562 358 GYLVnRHITITTIFLIFCISIFIGVI 383
Cdd:cd17330   321 GPLY-SFLGPGVPFLLAAGLLLIALF 345
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
32-163 1.17e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 62.59  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  32 IIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMG 111
Cdd:cd17323    21 ALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFF 100
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1011946562 112 LGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGW 163
Cdd:cd17323   101 GSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGW 152
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
27-388 1.37e-10

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 62.25  E-value: 1.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  27 GMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIIT-----LLLFSIGSGLSALTTTLTAF 101
Cdd:cd06173    16 WIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAVLALLALLGSLSLWLL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 102 LVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLR 181
Cdd:cd06173    96 LVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLL 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 182 WGLPdSPRFTSARKEETVWDNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMT--- 258
Cdd:cd06173   176 LFIR-RPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAafg 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 259 LAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTG 338
Cdd:cd06173   255 VGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRV 334
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1011946562 339 AGMAASFGRIGGILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVWVL 388
Cdd:cd06173   335 FSVYNALNSGAMPLGALLAGLLAD-ALGLSAVFLLAGALLLLAALLLLLL 383
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
33-385 2.40e-10

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 61.63  E-value: 2.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  33 IAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGL 112
Cdd:TIGR00710  28 FPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGA 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 113 GGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRWGLPDSprfTS 192
Cdd:TIGR00710 108 SAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPE---TL 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 193 ARKEETVWDNIVKVWSSSYRKETFMLWVlwFCVVFSYYGMFLWL---PSVMVMKGFSLIKSFEYVLIM-TLAQLPGYFSA 268
Cdd:TIGR00710 185 PYEARIQISTYFETFLLLLKSKMFWGYA--LIYGASFGGFFAFFsgaPFVYIDIMGVSPSVFGLLFALnIIAMIFGGFLN 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 269 AWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLG-AWGALYAYTPElYPTSIRGTGAGMAAS-FG 346
Cdd:TIGR00710 263 GRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGiGNSMISSIAMA-YALEDFPHVAGTASAlFG 341
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1011946562 347 RIGGILGPLfVGYLVNRhITITTIFLIFCISIFIGVIAV 385
Cdd:TIGR00710 342 TLRLVLGAI-VGYLVSL-IHGNTAWPMSLSCLVLAVVSV 378
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
28-107 4.53e-10

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 60.68  E-value: 4.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  28 MLSFI--------IAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLT 99
Cdd:PRK11043   16 MLGFLatdmylpaFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAA 95

                  ....*...
gi 1011946562 100 AFLVLRFL 107
Cdd:PRK11043   96 QLLVLRFV 103
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
9-131 8.71e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 59.92  E-value: 8.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   9 RKLLGVAGLGWMFDAMdvgMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIG 88
Cdd:COG2211   231 LLLLLAYLLFFLALAL---VAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1011946562  89 SGLSAL--TTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQE 131
Cdd:COG2211   308 LLLLFFlgPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDE 352
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
6-165 1.19e-09

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 59.55  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   6 ISQRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLF 85
Cdd:cd06173   205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  86 SIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQT 165
Cdd:cd06173   285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
59-165 2.54e-09

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 58.32  E-value: 2.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  59 AVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVL 138
Cdd:cd17370   248 ALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGL 327
                          90       100
                  ....*....|....*....|....*..
gi 1011946562 139 LESFWAVGWLLSALISYFVIPTYGWQT 165
Cdd:cd17370   328 FNTVVGIGWLLASLIAGYLWDLISPSA 354
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
39-389 4.03e-09

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 58.01  E-value: 4.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  39 DWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLlfsIGSGLSALT-----TTLTAFLVLRFLIGMGLG 113
Cdd:cd17318    50 EFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSIL---ITALLTLLTplaarGGYGALIVLRILQGLAQG 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 114 GELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTA--LLLAAIPALYALYLRWGLPdsprft 191
Cdd:cd17318   127 VTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIfyIFGGLGLLWCLLWFFLVLP------ 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 192 sarkeetvwdnivkVWSssyrketfmLWVLWFCVVFSYYGMFLWLPSVM-VMKGFSLIK-----SFEYVLIMTLAQLPGY 265
Cdd:cd17318   201 --------------VWA---------IVVAHFGHNWGFYTLLTELPTYMsDVLHFNIKSngflsSLPYLAMWICSIVGGY 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 266 FsAAWLIER------AGRKFVLITYLIGTAVSAYFFG-NADSLALLMTFGILLSFFNLGAWGALYAYTPELYPtSIRGTG 338
Cdd:cd17318   258 L-ADWLRSRgilsttTVRKLFTSIGFLGPGVFLIALGyLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAP-NYAGTL 335
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1011946562 339 AGMAASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFI---GVIAVWVLG 389
Cdd:cd17318   336 MGITNTAATIAGIISPLIVGAIVKNDQTIGQWRIVFFISAAIyilGAIFYLIFG 389
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
52-164 4.68e-09

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 57.72  E-value: 4.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  52 SINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQE 131
Cdd:PRK10473   45 SVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRR 124
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1011946562 132 RGKAVVLLESFWAVGWLLSALISYFVIPTYGWQ 164
Cdd:PRK10473  125 RAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQ 157
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
216-396 8.68e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 56.52  E-value: 8.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 216 FMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFF 295
Cdd:COG2814    13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 296 GNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNrHITITTIFLIFC 375
Cdd:COG2814    93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFGWRWVFLVNA 171
                         170       180
                  ....*....|....*....|.
gi 1011946562 376 ISIFIGVIAVWVLGKETKQQE 396
Cdd:COG2814   172 VLALLALLLLLRLLPESRPAA 192
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
14-194 1.03e-08

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 56.73  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  14 VAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSA 93
Cdd:cd17435     5 TAAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  94 LTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISY-FVIPTYGWQTALLLAAI 172
Cdd:cd17435    85 CSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYaFANVSNGWKYMFGLVIP 164
                         170       180
                  ....*....|....*....|..
gi 1011946562 173 PALYALYLRWGLPDSPRFTSAR 194
Cdd:cd17435   165 LAALQAIAMYFLPPSPRFLVMK 186
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
26-384 1.13e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 56.41  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  26 VGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLR 105
Cdd:cd17477    12 SGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLR 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 106 FLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALIsYFVIPTYGWQTALLLAAIPALYALYLRWGLP 185
Cdd:cd17477    92 FVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGALPFLIAAVLLLLALVPLLLTRR 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 186 DSPRFTSARKEetvwdNIVKVWSSSyrketFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGY 265
Cdd:cd17477   171 AAPEIEEAESI-----SLRRLLRIA-----PLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQ 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 266 FSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMtfgILLSFFNLGAWGALY----AYTPELYPTSIRGTGAGM 341
Cdd:cd17477   241 WPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLAL---LVLLFLWGGAAGPLYtlalALAGDRLPGDELVAANAA 317
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1011946562 342 AASFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIA 384
Cdd:cd17477   318 LLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
217-398 2.62e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 55.27  E-value: 2.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 217 MLWVLWFCVVFSYYGMFLWLPSVMVMK---GFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAY 293
Cdd:COG2223     6 VLLLATLAFFLAFGVWYLWSVLAPPLAeefGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 294 FFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNrHITITTIFLI 373
Cdd:COG2223    86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA-AFGWRNAFLI 164
                         170       180
                  ....*....|....*....|....*
gi 1011946562 374 FCISIFIGVIAVWVLGKETKQQELA 398
Cdd:COG2223   165 LGILLLVVAVLAWLFLRDPPAGAAA 189
MFS_1 pfam07690
Major Facilitator Superfamily;
256-393 8.85e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.58  E-value: 8.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 256 IMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIR 335
Cdd:pfam07690  40 LFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEER 119
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1011946562 336 GTGAGMAASFGRIGGILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVWVLGKETK 393
Cdd:pfam07690 120 GRALGLVSAGFGLGAALGPLLGGLLAS-LFGWRAAFLILAILSLLAAVLLLLPRPPPE 176
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
35-135 1.24e-07

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 53.07  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  35 ALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSAL-TTTLTAFLVLRFLIGMGlG 113
Cdd:TIGR00886  27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLaVQSYSVLLLIRLFIGIA-G 105
                          90       100
                  ....*....|....*....|..
gi 1011946562 114 GELPVASTLVSESVPAQERGKA 135
Cdd:TIGR00886 106 GSFASCMPWISFFFPKKIQGTA 127
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
14-398 2.78e-07

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 52.11  E-value: 2.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  14 VAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSA 93
Cdd:cd17436     5 VSLLGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILT 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  94 LTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPT-YGWQTALLLAAI 172
Cdd:cd17436    85 LAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVlTGWRYMFGLAII 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 173 PALYALYLRWGLPDSPRfTSARKEETVWDNIVKVWSSSYRKETFMLWVLWFC-VVFSYYGMFLWLPSVMVMKGFSLIKSF 251
Cdd:cd17436   165 PAAIQFASILLLPKKPE-VLNIKDNMRRRTLVGLGLVLFQQFTGQPNVLCYAsTIFRSVGFQSNSSAVLASVGLGVVKVI 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 252 EYVLIMTLAqlpgyfsaawliERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFgilLSFFNLGAWGALYAYTPELYP 331
Cdd:cd17436   244 ATLLAMLFA------------DRAGRRSLLIAGCSVMAVSVSGIGLWITLLCLMAF---VSAFSIGFGPMTWLVLSEIYP 308
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011946562 332 TSIRGTGAGMAASFGRIGGILGPLFVGYLVNRhITITTIFLIFCISIFIGVIAVWVLGKETKQQELA 398
Cdd:cd17436   309 ADIRGRAFSFCNSFNWAANLLITLSFLDLIDV-IGLSWTFLLYGVVGVAGVVFIYLFVPETKGQSLE 374
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
30-388 2.90e-07

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 52.23  E-value: 2.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  30 SFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTL-TAFLVLRFLI 108
Cdd:cd17353    23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLpLLFLGYGVLG 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 109 GMGLGGELPVASTLVSESVPAQeRGKAVVLLESFWAVGWLL-SALISYFVIPTYGWQTALLLAAIPALYALYLRWGL--- 184
Cdd:cd17353   103 GIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIfSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIrdp 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 185 --PDSPRFTSARKEETVWDNIVKVWSSSYRKETFmlWVLWFCVVF-SYYGMFL---WLPSVMVMKGFSLIKSFEYVLIMT 258
Cdd:cd17353   182 pkGWVPPGVDPLANNAENSPRDYTPREMLRTPTF--WLLWLMFFLnATAGLMLigqAKPIGQEFAGLDAGIAALAVSILS 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 259 LAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALY-AYTPELYPTSIRGT 337
Cdd:cd17353   260 IFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFpALTADFFGTKNAGT 339
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1011946562 338 GAGMAASFGRIGGILGPLFVGYLVNRHiTITTIFLIFCISIFIGVIAVWVL 388
Cdd:cd17353   340 NYGLLYTAKGVGGLIGPIIAAYVLYTG-GYNAAFIIAAALSLVALALALLL 389
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
41-133 3.40e-07

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 52.08  E-value: 3.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  41 NLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVAS 120
Cdd:COG2270   270 GFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSR 349
                          90
                  ....*....|...
gi 1011946562 121 TLVSESVPAQERG 133
Cdd:COG2270   350 SLLARLIPPGREA 362
MFS_4 pfam06779
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ...
23-363 3.48e-07

Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.


Pssm-ID: 399632 [Multi-domain]  Cd Length: 365  Bit Score: 51.60  E-value: 3.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  23 AMDVGMLSF--IIAALQKDWNLSVEQMGWIGSINSIGMAVGALL--FGLLADRIGRKNVFIITLLLFSIGSGLSALTTTL 98
Cdd:pfam06779   4 GMGIGRFSYtpILPVMIAEGQFSLSQAGLLAAANYAGYLAGALLasFAWRHGASRLRPALLAGLLATVLLLLAMAATSSF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  99 TAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFvIPTYGWQTALLLAAIPALYAL 178
Cdd:pfam06779  84 WAVLLIRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPL-GLQLGLGGSSLWYGAGVLSAV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 179 YLRWGLPDSPRFTSARKEETVWDNIVKVWSSSyrkeTFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMT 258
Cdd:pfam06779 163 LTLAVFPLLPRRAPRHASAPAPAAKPLQRSLP----LWILTLAYGLAGFGYIITATFLPAMARDGFGGPAAAALFWSLFG 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 259 LAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTG 338
Cdd:pfam06779 239 LAAALGVLVWLRAAKRWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSLLFGGTFMAITSLVMQLARELAPPAPRRLL 318
                         330       340
                  ....*....|....*....|....*
gi 1011946562 339 AGMAASFGrIGGILGPLFVGYLVNR 363
Cdd:pfam06779 319 GLMTASFG-IGQILGPLLASLLTAA 342
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
9-136 3.70e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 51.45  E-value: 3.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   9 RKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIG 88
Cdd:cd17316   177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1011946562  89 SGLS--ALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAV 136
Cdd:cd17316   257 ALPLfyLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGV 306
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
22-153 5.90e-07

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 51.07  E-value: 5.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  22 DAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAF 101
Cdd:cd17390     8 DLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALL 87
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1011946562 102 LVLRFLIGMgLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALI 153
Cdd:cd17390    88 FLSRIPLGI-FKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVV 138
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
49-386 1.02e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 50.23  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  49 WIGSINSIGMAVGALL---FGLLADRIG-RKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVS 124
Cdd:cd17370    35 AVGLIEGLAEALGSLLrlfSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLA 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 125 ESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGW--QTALLLAAIPALYALYLRWGLPDSPRFTSARKEETVWDN 202
Cdd:cd17370   115 DATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGnyRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTS 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 203 IvKVWSSSYRketfMLWVLWFCVVFSYYG-MFLWLPSVMVMKGFSLIKSFeYVLIMTLAQLPGYFsAAWLIERAGRKFVL 281
Cdd:cd17370   195 L-KKLPKAFW----LYLLAVALFALGNFSfAFLILRAQELGLSAALIPLL-YALFNLVYALAAYP-AGRLSDRIGRKKLL 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 282 I-TYLIGTAVSAYFFGNADSLALLmtFGILLSFFNLGAWGALY-AYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGY 359
Cdd:cd17370   268 IlGYLSLALAYLGFALGSSLWLLL--LGFILWGLYMGAQESIErAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGY 345
                         330       340
                  ....*....|....*....|....*..
gi 1011946562 360 LVNrHITITTIFLIFCISIFIGVIAVW 386
Cdd:cd17370   346 LWD-LISPSAAFLFSAVLALIALLLLL 371
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
46-165 1.35e-06

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 49.91  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  46 QMGWIGSINSIGMAVGALLFGLLA-DRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVS 124
Cdd:cd17490   231 QLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSI 310
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1011946562 125 ESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQT 165
Cdd:cd17490   311 EGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQT 351
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
218-396 1.37e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.12  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 218 LWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGN 297
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 298 ADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITITTIFLIFCIS 377
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
                         170
                  ....*....|....*....
gi 1011946562 378 IFIGVIAVWVLGKETKQQE 396
Cdd:cd06174   161 LALLAAILLLLVVPDPPES 179
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
42-388 1.70e-06

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 49.50  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  42 LSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSI--GSGLSALTTTLTAFLVLRFLIGMGLGGELPVA 119
Cdd:cd17335    29 LSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVlfFLSLFFVAQIFWLLLLLVILGAFFSAPVVPLV 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 120 STLVSESVpaQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRWGLPDSPRFTS-ARKEET 198
Cdd:cd17335   109 DSITLQYL--GEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRPkHPEPNE 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 199 VWDNIVKVWSSSyrkeTFMLWVLWFCVVFSYYGMFLWLpSVMVMKGFSLIKSFEYVL--IMTLAQLPGYFSAAWLIERAG 276
Cdd:cd17335   187 NTGGLLALLRNP----RVLAFLLVAFLMGFGHGLIYSF-LFWHLQDLGGSKTLIGLLwtVGVVSEIPFFFFSSRLIQRFG 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 277 RKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGM--AASFGrIGGILGP 354
Cdd:cd17335   262 HVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLlqGLYFG-LGGGLGS 340
                         330       340       350
                  ....*....|....*....|....*....|....
gi 1011946562 355 LFVGYLVNrHITITTIFLIFCISIFIGVIAVWVL 388
Cdd:cd17335   341 LIGGYLYE-AFGARTTFRFFAIAALAGLLAFFLI 373
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
42-376 2.83e-06

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 49.10  E-value: 2.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  42 LSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVAST 121
Cdd:cd17433    38 LDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPV 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 122 LVSESVPAQERGKAVVLLESFWAVGWLLSALISYFviptYGWQTALLLAAIPALYALYLRWGLPDSPRF--TSARKEETV 199
Cdd:cd17433   118 YISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLV----LDWRWLAVLGSIPPTLMLLLMCFMPETPRFllTQHRRQEAM 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 200 --------------WDNIVKVWSSSYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVL---------- 255
Cdd:cd17433   194 aalrflrgpdqgweWECIGIEQSFHLEEQSFSLALLKQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIfeeakfkdss 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 256 ----IMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGnadsLALLMTFGILLSFFNLGaWGAL-YAYTPELY 330
Cdd:cd17433   274 vasvIVAAIQVLFTAVAALIMDRAGRKVLLVLSGVVMVFSTAAFG----WLAVGSMGFFIAGFAVG-WGPIpWLVMSEIF 348
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1011946562 331 PTSIRGTGAGMAA------------SFGRIGGILGPLFVGYLVNRHITITTIFLIFCI 376
Cdd:cd17433   349 PLHVRGVASGICVltnwlmaflvtkEFSSLMEVLSSYGTFWLFSAFCAFSVLFTLFCV 406
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
37-133 3.39e-06

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 48.78  E-value: 3.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  37 QKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGEL 116
Cdd:cd17313   273 SSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATIN 352
                          90
                  ....*....|....*..
gi 1011946562 117 PVASTLVSESVPAQERG 133
Cdd:cd17313   353 INPYPLVSDYHSESGRG 369
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
60-388 4.24e-06

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 48.51  E-value: 4.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  60 VGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTT--------LTAFLVLRFLIGMGLGGELPVASTLVSESVPAQE 131
Cdd:cd17366    55 LGGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTyatigvwaPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRK 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 132 RGKAVVLLESFWAVGW--------LLSALISYFVIPTYGWQTALLLAAIPALYALYLRWGLPdsprftsarkeetvwdni 203
Cdd:cd17366   135 RGFLGSWLEFGTLAGFilgaglvtLLTLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLRRPLL------------------ 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 204 vkvwsssyrkeTFMLWVLWFCVVfsYYGMFLWLPSVMVMK-GFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLI 282
Cdd:cd17366   197 -----------ICIGLVLVFNVT--NYMLLSYMPSYLEETlGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYA 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 283 TYLIGT---AVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRgtGAGMAASFGRIGGILG---PLF 356
Cdd:cd17366   264 AGLAGLlvlAVPAFLLMNSGSIAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVR--YSALAIAFNISVSLFGgttPLV 341
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1011946562 357 VGYLVNRHITITTIFLIFCISIFIGVIAVWVL 388
Cdd:cd17366   342 ASWLVSATGNPLMPAYYLMVAAVVGLVAVLFL 373
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
42-165 4.68e-06

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 48.38  E-value: 4.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  42 LSVEQMG---------WIGSINSIGM---AVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIG 109
Cdd:PRK09874   39 LYVEQLGvtghsalnmWSGLVFSITFlfsAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLG 118
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1011946562 110 MgLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQT 165
Cdd:PRK09874  119 L-LGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRP 173
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
11-128 7.08e-06

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 47.62  E-value: 7.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  11 LLGVAGLgwmFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSG 90
Cdd:cd17336     7 LLCLLGL---LQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCF 83
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1011946562  91 LSALTttlTAFLVLRFLIGMGLGGELPVASTLVSESVP 128
Cdd:cd17336    84 LLALP---HFLFVGQFLLGIGSSPLYTLGITYIDDNVS 118
PRK10504 PRK10504
putative transporter; Provisional
1-128 7.68e-06

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 47.80  E-value: 7.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   1 MIQQTISQRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFII 80
Cdd:PRK10504    1 MTDLPDSVRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFT 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1011946562  81 TLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVP 128
Cdd:PRK10504   81 AIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVP 128
xylE PRK10077
D-xylose transporter XylE; Provisional
27-345 1.04e-05

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 47.38  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  27 GMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIgSGLSAL------------ 94
Cdd:PRK10077   37 SLNTVFVAPQNLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFI-SALGSAwpefgftsigpd 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  95 -TTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVvlleSFWAVGWLLSALISYFV------------IPTY 161
Cdd:PRK10077  116 nTGYVPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLV----SFNQFAIIFGQLVVYFVnyfiarsgdaswLNTD 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 162 GWQTALLLAAIPALYALYLRWGLPDSPRFTSARKEETVWDNIVK---------------VWSSSYRKE------TFMLWV 220
Cdd:PRK10077  192 GWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRkimgntlatqalqeiKHSLDHGRKtggkllMFGVGV 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 221 LWFCVVFSYYGMFL-------WLPSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAY 293
Cdd:PRK10077  272 IVIGVMLSVFQQFVginvvlyYAPEIFKTLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGMF 351
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1011946562 294 FFGNADSLALL----MTFGILLSFFNLGAWGAL-YAYTPELYPTSIRGTGAGMAASF 345
Cdd:PRK10077  352 SLGTAFYTQAPgivaLLSMLFYVAAFAMSWGPVcWVLLSEIFPNAIRGKALAIAVAA 408
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
30-390 1.05e-05

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 47.33  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  30 SFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKnvfiitlLLFSIGSGLSALTT-------TLTAFL 102
Cdd:cd17343    23 SFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISAR-------WLFSSGLVLSGLTTvafsgssSVWVFS 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 103 VLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRW 182
Cdd:cd17343    96 ILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCL 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 183 GL----PDSPRFTSARKEETVWDNIVKVWSSSYRKETFMLWVLWFcVVFSYYGMFLWLPSV--------MVMKGFSLIKS 250
Cdd:cd17343   176 LFiknePSDVGLNNIEEEESKGKKKKSPRGESTLKELLLSPFLWL-LSLGYLVVFGVKTAVtdwgqlflIQDKGQSALTG 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 251 FEYVLIMTLAQLPGYFSAA----WLIERAG-------RKFVLITYLIGTAVSAYFF----GNADSLALLMTFGILLSFFN 315
Cdd:cd17343   255 SSFMSSLEVGGFVGSIAAGylsdWAVAKHGsssrgnpRMPLALVFMAGLTVSLHLFrvhiTSDSSELFILLLGFLIGFSL 334
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011946562 316 LGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVWVLGK 390
Cdd:cd17343   335 YGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAK-HYDWRTAFLLLEILCAITVVILFLLRN 408
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
3-361 1.20e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.20  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   3 QQTISQRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIG-----RKNV 77
Cdd:COG2211     4 KKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPW 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  78 FIITLLLFSIGSGLSALTTTLTA------FLVLRFLIGMGLGGELPVASTLVSESVP-AQERGKAVVLLESFWAVGWLLS 150
Cdd:COG2211    84 ILIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLA 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 151 ALISYFVIPTYG-------WQTALLLAAIPALYALYLRWGLPDspRFTSARKEETVWDNIVKVWSSSYRKETFMLWVLWF 223
Cdd:COG2211   164 SVLPPPLVAAFGgdaalgyRLTALIFAVLGLLAFLLTFFGTKE--RPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFF 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 224 CVVFSYYGMFLWLPSVMVMKGFSLIKSFeyVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVS--AYFFGNADSL 301
Cdd:COG2211   242 LALALVAALLLYYFKYVLGLSAALVGLL--LALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGllLLFFLGPGNL 319
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011946562 302 ALLMTFGILLSFFNLGAWGALYAYTPEL-----YPTSIRGTGAGMAAS--FGRIGGILGPLFVGYLV 361
Cdd:COG2211   320 WLLLVLAALAGIGLGAILVLPWAMLADVvdydeWKTGRRREGLYFGIFtfAIKLGQALAGALAGLLL 386
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
52-386 1.59e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 46.49  E-value: 1.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  52 SINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMgLGGELPVASTLVSESVPAQE 131
Cdd:cd17391    43 SSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FSGYVPNATALIASQTPKEK 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 132 RGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLR-WGLPDSprFTSARKEETVwdNIVKVWSS- 209
Cdd:cd17391   122 SGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTlFFVKED--FKPVEKKKMV--STKEVWNSv 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 210 SYRKETFMLWVLWFCVVFSYYGMFLWLP-SVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWL---IERAGRKFVLITYL 285
Cdd:cd17391   198 PNPSLLISLFVTTFIIQLANQSIEPILTlYIRQLMGDASNLAFISGLVFSATGVSSLLSAPRLgklGDRIGHHRILLGAL 277
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 286 IGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLfVGYLVNRHI 365
Cdd:cd17391   278 LASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPL-LGSAIAAHF 356
                         330       340
                  ....*....|....*....|.
gi 1011946562 366 TITTIFLIFCISIFIGVIAVW 386
Cdd:cd17391   357 GYRAVFVVTALLVLLNAIWSF 377
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
48-153 1.66e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 46.49  E-value: 1.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  48 GWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESV 127
Cdd:cd17391   243 GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKIT 322
                          90       100
                  ....*....|....*....|....*.
gi 1011946562 128 PAQERGKAVVLLESFWAVGWLLSALI 153
Cdd:cd17391   323 PKEVAGRIFGYNQSFQYLGNVAGPLL 348
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
33-380 1.87e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 46.47  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  33 IAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGL 112
Cdd:cd17327    29 VMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFE 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 113 GGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVI------PTYGWQTALLLA-AIPALYALYLRWGLP 185
Cdd:cd17327   109 SGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFkilgvgGLAGWRWLFIIEgLITIIIGLVIFFWLP 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 186 DSP---RFTSARKEETVW-----DNIVKVWSSSYRKE---------TFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLI 248
Cdd:cd17327   189 DNPskaWFLTEEEKELAVerlraNQTGKGDQKFKWKQikeafkdprTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSL 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 249 KSFEYVLIMTLAQLPGYFSAAWLIERAGRK--FVLITYLIGTA-----------VSAYFFGNADSLALLMTFGILLSFFN 315
Cdd:cd17327   269 QTNLLSVPIGALGAVSLLIAALLSDRFKKRglFAIFACVLALVgsiillaapnpPGAYFAAYILGGGSYAGFPILLSWIS 348
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011946562 316 LGAWGAlyaytpelyptSIRGTGAGMAASFGRIGGILGP-LFVGYLVNRHITITTIFLIF-CISIFI 380
Cdd:cd17327   349 SNCAGY-----------TKRATVLAIMLIFYNVGNIVAPqIFRAGDAPRYIPGNIALLVCaCVSIVL 404
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
57-109 2.31e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 46.06  E-value: 2.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1011946562  57 GMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIG 109
Cdd:PRK11102   38 GFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHG 90
PRK10642 PRK10642
proline/glycine betaine transporter ProP;
9-361 2.32e-05

proline/glycine betaine transporter ProP;


Pssm-ID: 182611 [Multi-domain]  Cd Length: 490  Bit Score: 46.24  E-value: 2.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   9 RKLLGVAGLGWMFDAMDVGMLSFIIAALQK----DWNLSVEQMGWIG--SINSIGMAVGALLFGLLADRIGRKNVFIITL 82
Cdd:PRK10642   15 RKAITAASLGNAMEWFDFGVYGFVAYALGKvffpGADPSVQMIAALAtfSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  83 LL-----FSIGSGLSALTTTLTA---FLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSA--- 151
Cdd:PRK10642   95 VImsistFCIGLIPSYATIGIWApilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAgvv 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 152 -LISYFV----IPTYGWQTALLLAAIPALYALYLRWGLPDSPRFT--SARKEETVWDNIVKVWSSSYRKETFMLW-VLWF 223
Cdd:PRK10642  175 vLISTIVgeanFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQqhVDKLEQGDREGLQDGPKVSFKEIATKHWrSLLT 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 224 CVVF------SYYGMFLWLPSVMvmkGFSLIKSFEYVLIMTLAQLPGYF----SAAWLIERAGRK-FVLI--TYLIGTAV 290
Cdd:PRK10642  255 CIGLviatnvTYYMLLTYMPSYL---SHNLHYSEDHGVLIIIAIMIGMLfvqpVMGLLSDRFGRRpFVILgsVALFVLAI 331
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011946562 291 SAYFFGNADSLAL----LMTFGILLSFFNlgawGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLV 361
Cdd:PRK10642  332 PAFILINSNVIGLifagLLMLAVILNCFT----GVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLV 402
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
40-114 3.10e-05

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 45.54  E-value: 3.10e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011946562  40 WNLSVEQMGWIgsinsIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGG 114
Cdd:cd17445    36 WLVPLEQVCFI-----LGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAG 105
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
9-154 3.13e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.50  E-value: 3.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   9 RKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADR-IGRKNVFIITLLLFSI 87
Cdd:cd06174   203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMAL 282
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011946562  88 GSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALIS 154
Cdd:cd06174   283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349
PRK09952 PRK09952
shikimate transporter; Provisional
60-361 3.19e-05

shikimate transporter; Provisional


Pssm-ID: 182163 [Multi-domain]  Cd Length: 438  Bit Score: 45.88  E-value: 3.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  60 VGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTA--------FLVLRFLIGMGLGGELPVASTLVSESVPAQE 131
Cdd:PRK09952   79 LGGVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTigwwapvlLVTLRAIQGFAVGGEWGGAALLAVESAPKNK 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 132 RGKAVVLLESFWAVGWLLS----ALISYFV----IPTYGWQTALLLAAIPALYALYLRWGLPDSPRFTSARKEETVWDNI 203
Cdd:PRK09952  159 KAFYSSGVQVGYGVGLLLStglvSLISMMTtdeqFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKKR 238
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 204 VKVWSSSYR--KETFMLWVLWFCVVFSYYgmflwlpsvmVMKGFSLIKSFEYV-----LIMTLAQLPGYFSA------AW 270
Cdd:PRK09952  239 IPVIEALLRhpGAFLKIIALRLCELLTMY----------IVTAFALNYSTQNLglpreLFLNIGLLVGGLSCltipcfAW 308
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 271 LIERAGRKFVLIT-YLIGTAVSAYFFG--NADSLALLMTFGILLSffNLGAWGALYAYTP---ELYPTSIRGTGAGMAAS 344
Cdd:PRK09952  309 LADRFGRRRVYITgALIGTLSAFPFFMalEAQSIFWIVFFSIMLA--NIAHDMVVCVQQPmftEMFGASYRYSGAGVGYQ 386
                         330
                  ....*....|....*...
gi 1011946562 345 FGR-IGGILGPLFVGYLV 361
Cdd:PRK09952  387 VASvVGGGFTPFIAAALV 404
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
66-385 3.72e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 45.29  E-value: 3.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  66 GLLADRIGRKNVFIITLLLFSI-GSGLSALTTTLTAFLVLRFLIGMGlggelpvASTLVSESV------PAQERGKAVVL 138
Cdd:cd17490    52 GILSDRIGKRKLFIIIGLLFTVlASLIMILFPSPWGLLIARFLSGIA-------AATWVSFTVlyasyfPPDEAAKAMGL 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 139 LESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRWGLPDSPRftSARKEETVWDNIVKVWSSSYrketfml 218
Cdd:cd17490   125 INLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERR--EKKPVLTELKELLSVLKDKK------- 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 219 wvLWFcvvFSYYGMFLWLPSVMVMKGFSLI-------KSFEYVLIMTLAQLPG----YFSAAWLIERAGRKFVLITYLIG 287
Cdd:cd17490   196 --LLF---FSLLAILQQMITFSTTFGFTPLiakqlgaSSFQLGLLSIIYLLPNalasLLSGTLFYKKLGERNTIIIGFLL 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 288 TAVSAYFFGNADSLALLMtfgiLLSFFNLGAWGALYAYTPELYPTSI----RGTGAGMAASFGRIGGILGPLFVGYLVNr 363
Cdd:cd17490   271 LGAYCFLIPFAPNLTLLY----LLQALNGFGTGILFPLLMSLSIEGVpaeqRSTAMGFFQAIYALGMFLGPVLVGIISE- 345
                         330       340
                  ....*....|....*....|..
gi 1011946562 364 HITITTIFLIFCISIFIGVIAV 385
Cdd:cd17490   346 AFGLQTGFFVIGVIALLAAILS 367
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
59-388 3.95e-05

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 45.32  E-value: 3.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  59 AVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVL 138
Cdd:cd17361    65 LVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIG 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 139 LESFWAVGWLLSALISYFV--IPTYGWQTALLLAAIPALYALYLRWGLPDSPRFTSarkeetvwdnivkvwsssyrketf 216
Cdd:cd17361   145 FQLAITIGILIANLINYGTskIKPNGWRLSLGLAAVPALILLLGSLFLPETPNSPQ------------------------ 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 217 mlwvLWFCVVfsyYGMFLWL----------PSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLI---- 282
Cdd:cd17361   201 ----LVIAIL---IPFFQQLtginvimfyaPVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFLLLeggv 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 283 ----TYLIGTAVSAYFFG------NADSLALLMTFGILLSFFNlGAWGALYAYTP-ELYPTSIRGTGAGMAASFGRIGG- 350
Cdd:cd17361   274 qmlaSQVAIGILLAVKFGdggelpKAYAIAVVVLICLYVAAFA-WSWGPLGWLVPsEIFPLETRSAGQSLTVAVNFLFTf 352
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1011946562 351 ILGPLFVGYLVNRHItitTIFLIFCISIFIGVIAVWVL 388
Cdd:cd17361   353 VIAQAFLSMLCAMKF---GIFLFFAGWVVVMSLFVYFL 387
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
36-390 3.96e-05

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 45.26  E-value: 3.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  36 LQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTlTAFLVLRFLIGMGLGGE 115
Cdd:cd17339    25 IRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGI-ALLFLGTALAGAGIAVG 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 116 LPVASTLVSESVPAQergkaVVLLESFWAVGWLL-SALISYFVIP-----TYGWQTALLLAAIPALYALYLRWGLP-DSP 188
Cdd:cd17339   104 NVLLPSLIKRDFPRR-----VGLMTGLYTTSMNLgAALASGLSVPlaqalGGGWRGALAIWALPALLALLIWLPQLrRRK 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 189 RFTSARKEETVwdniVKVWSSsyrKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSA 268
Cdd:cd17339   179 RAAAAAAPLTK----ISVWRS---PLAWQVTLFMGLQSLLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLV 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 269 AWLIERAGRKFVLITyligTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYP---TSIRGTGA--GMAA 343
Cdd:cd17339   252 PILATRLKNQRPIVV----LLAVLFIIGVLGLLFAPTALALLWAVLLGLGGGAAFSLALTLISlrsSDPAEAAAlsGMAQ 327
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1011946562 344 SFGRIGGILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVWVLGK 390
Cdd:cd17339   328 SVGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVLQLVAGLGAGR 374
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
9-135 4.70e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 45.24  E-value: 4.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   9 RKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIG 88
Cdd:cd17321   168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1011946562  89 SGLSALT---TTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKA 135
Cdd:cd17321   248 LLLLALLgadSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAA 297
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
36-386 6.69e-05

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 44.54  E-value: 6.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  36 LQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKnVFIITLLLFS------IGSGLSAlTTTLTAFLVLRFLIG 109
Cdd:cd17345    29 LIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPK-RFLAIGLILSaiinilIGFVPSA-TSSVGLMFILLFLNG 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 110 MGLGGELPVASTLVSESVPAQERGKAVvlleSFWAV-----GWLLSALI--SYFVIPTYGWQTALLLAAIPALYALYLRW 182
Cdd:cd17345   107 WFQGMGWPPSGRTMVHWFSKKERGTWT----SIWNIshnvgGGLVGPLAglGLAIFGDGWWRGAFIFPAIIAIIVAVIVL 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 183 ----------GLP----------DSPRFTSARKEETVWDNIVKvwsssYRKETFMLWVLWFCVVFSY---YGMFLWLPSV 239
Cdd:cd17345   183 flgkdtpeseGLPpieeykgdypEEADGEEEEQELSAWEIFVK-----YVLKNKLLWYIAIANVFVYlvrYGILDWAPTY 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 240 MV-MKGFSLIKSFEYVLIMTLAQLPGYFSAAWL---IERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFN 315
Cdd:cd17345   258 LSeVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLsdkLFKGRRAPTGIIFMILVIVALIVYWLAPNVLVDLIALIALGFLI 337
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011946562 316 LGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGG-ILGPLFVGYLVNRH--ITITTIFLIFCISIFIGVIAVW 386
Cdd:cd17345   338 YGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGsVLATALIGIIVDHFgwNGGFIVLLASCILAIIFLALVA 411
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
9-155 7.33e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 44.48  E-value: 7.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   9 RKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRI---GRKNVFIITLLLF 85
Cdd:cd17319   179 RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLA 258
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1011946562  86 SIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESF---------WAVGWLLSALISY 155
Cdd:cd17319   259 AVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGgnlggfvapLLIGYLVDATGSY 337
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
270-391 8.73e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 44.14  E-value: 8.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 270 WLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNlGAWGALYAYTPELYPTSIRGTGAGMAASFGRIG 349
Cdd:cd17390    53 SWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFK-HTQSLCKAYLSDLVSEQERSRVLGRFNAASSLG 131
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1011946562 350 GILGPLFVGYLVNRHITITTIFLIFCISIFIGVIAVWVLGKE 391
Cdd:cd17390   132 FILGPVVGGHLAETDGGFYYVALLCSAIFILNAGLVWFLLSK 173
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
36-362 1.17e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 43.70  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  36 LQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLV-LRFLIGMGLGG 114
Cdd:cd17352    29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLtYGVLGGLGLGL 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 115 ELPVASTLVSeSVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALylrwglpdsprftsar 194
Cdd:cd17352   109 IYSPAIVIVG-QYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLC---------------- 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 195 keetvwdnIVKVWSSSYRKETFMLWVLW-FCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIE 273
Cdd:cd17352   172 --------VCGLLLRLLKDPTFVLLALGvSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAD 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 274 RA--GRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGI 351
Cdd:cd17352   244 KPriGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAAL 323
                         330
                  ....*....|.
gi 1011946562 352 LGPLFVGYLVN 362
Cdd:cd17352   324 VGPPIAGLLRD 334
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
24-149 1.23e-04

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 44.14  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  24 MDVGMLSFIiaalqkdWNLSVeqmgwigSINSIGMAVGALLFGLLADRIGRK------NVFIItllLFSIGSGLSALTTT 97
Cdd:cd17432    43 LEESTLTLL-------WSLTV-------SIFPLGGLFGSLLVGPLVIRLGRKgtlllnNIFAI---VAAILMGLSKIAKS 105
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1011946562  98 LTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLL 149
Cdd:cd17432   106 FEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILL 157
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
25-114 1.38e-04

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 43.66  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  25 DVGMLSFIIAALQKDWNLsVEQMGWIGSINSI----GMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTA 100
Cdd:cd17373     2 DYGIRAGLVQNAVSKWDL-VCDNGWKVHLEQFslllGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTM 80
                          90
                  ....*....|....
gi 1011946562 101 FLVLRFLIGMGLGG 114
Cdd:cd17373    81 FSTLRFLEGFCLAG 94
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
56-113 1.64e-04

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 43.39  E-value: 1.64e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1011946562  56 IGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLG 113
Cdd:PRK15402   59 AGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLC 116
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
11-146 2.78e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 43.00  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  11 LLGVAGL-GWMFDAMDVGMLSFIIAALQKDWnlsvEQMGWIGSINSIGMAVGALLFGLLADRIGR-KNVFIITLLLFSIG 88
Cdd:cd06179   267 ILIVAFVeGMIFYSLNIFWPQQISLLFTTDP----LKAGLYQLPFGLGTLFGAILAGLLLTKIKHiKWQLVAGFVLFTAF 342
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  89 SGLSALTT--TLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVG 146
Cdd:cd06179   343 LALLALITpdNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALG 402
emrD PRK11652
multidrug transporter EmrD;
63-113 2.91e-04

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 42.59  E-value: 2.91e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1011946562  63 LLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLG 113
Cdd:PRK11652   61 LFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTG 111
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
57-109 4.90e-04

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 42.12  E-value: 4.90e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1011946562  57 GMAVGALLfGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIG 109
Cdd:PRK15403   64 GMALQWLL-GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQG 115
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
30-164 5.36e-04

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 41.62  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  30 SFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIG 109
Cdd:cd17488    23 NAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAVLWTLNA 102
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1011946562 110 MGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQ 164
Cdd:cd17488   103 FFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWR 157
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
259-388 6.20e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 41.41  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 259 LAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNlGAWGALYAYTPELYPTSIRGTG 338
Cdd:cd17330    45 LGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTG-GNVSVAQAYIADITDEEERAKA 123
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1011946562 339 AGMAASFGRIGGILGPLFVGYLVNRHiTITTIFLIFCISIFIGVIAVWVL 388
Cdd:cd17330   124 FGIISAAFGLGFILGPALGGFLSTPY-GYALPFLVAAALALLNLVLVLFF 172
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
218-387 6.36e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.44  E-value: 6.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 218 LWVLWFCVVFSYYGMFLWLPSVMV----MKGFSLIKSFEYVLIMTLAQLPGYFSAAWLIERAGRKFVLITYLIGTAVSAY 293
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWPFMAIylhqQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 294 FFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGRIGGILGPLFVGYLVNRHITITTIFLI 373
Cdd:cd17329    81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
                         170
                  ....*....|....
gi 1011946562 374 FCISIFIGVIAVWV 387
Cdd:cd17329   161 VLFLLAALVLLFLL 174
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
9-153 6.95e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 41.41  E-value: 6.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   9 RKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSI-GMAVGALLFGLLADRIGRKNVFIITLLLFSI 87
Cdd:cd17330   174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIaGILAQLLLIPRLAKRLGERKLLRLGLLLAII 253
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011946562  88 GSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESVPAQERGKAVVLLESFWAVGWLLSALI 153
Cdd:cd17330   254 GLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLL 319
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
10-136 8.93e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.07  E-value: 8.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  10 KLLGVAGLGWMfdAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKN-------VFIITL 82
Cdd:cd17475   201 WLIAIAGALLV--APQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRrrpvlviTAAIAA 278
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1011946562  83 LLFSIGSGLSALTTTLTAFLVLrFLIGMGLGGELPVASTLVSESVPAQERGKAV 136
Cdd:cd17475   279 AALLVLSLLSPGTPLWLLVLLL-ILLGLFAIGWNGLYLTLVAESAGPEQAGTAL 331
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
9-113 9.90e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 40.97  E-value: 9.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562   9 RKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIG 88
Cdd:cd17369   228 RALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALF 307
                          90       100
                  ....*....|....*....|....*..
gi 1011946562  89 S--GLSALTTTLTAFLVLRFLIGMGLG 113
Cdd:cd17369   308 AfpFFWLLDTGSTWLIVLAAVVVLGVL 334
PRK14995 PRK14995
SmvA family efflux MFS transporter;
23-111 1.28e-03

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 40.87  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  23 AMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFL 102
Cdd:PRK14995   19 AIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI 98

                  ....*....
gi 1011946562 103 VLRFLIGMG 111
Cdd:PRK14995   99 ATRALLAIG 107
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
268-388 1.36e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 40.18  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 268 AAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAASFGR 347
Cdd:COG0477    69 FGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIG 148
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1011946562 348 IGGILGPLFVGYLVNrHITITTIFLIFCISIFIGVIAVWVL 388
Cdd:COG0477   149 LGLALGPLLGGLLVA-ALGWRWIFLINAPLGLLALVLRLRL 188
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
48-153 1.48e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 40.34  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  48 GWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGlGGELPVASTLVSESV 127
Cdd:cd17389    67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGIS-KGNVSLSTAIVADVT 145
                          90       100
                  ....*....|....*....|....*.
gi 1011946562 128 PAQERGKAVVLLESFWAVGWLLSALI 153
Cdd:cd17389   146 SPKKRSKGMALIGVAFSLGFIIGPMI 171
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
40-149 1.87e-03

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 40.14  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  40 WNLSVEQMGWIgsinsIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVA 119
Cdd:cd17443    36 WKVPLEKISYL-----LGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQGGTLAGVFLSL 110
                          90       100       110
                  ....*....|....*....|....*....|
gi 1011946562 120 STLVSESVPAQERGKAVVLLESFWAVGWLL 149
Cdd:cd17443   111 YIARLELCDPSHRLMVSMGAGFFSVAGELL 140
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
21-128 2.06e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 39.94  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  21 FDAMDVGMLSFIIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTA 100
Cdd:cd17476     9 LNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIF 88
                          90       100
                  ....*....|....*....|....*...
gi 1011946562 101 FLVLRFLIGMGLGGELPVASTLVSESVP 128
Cdd:cd17476    89 FIICRALQGLGPAFLLPNAMALLGRTYP 116
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
36-139 2.29e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.87  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  36 LQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSAL---TTTLTAFLVLRFLIGMGL 112
Cdd:cd17503   205 LQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFltpDTSLWLIILPLFIRGLGM 284
                          90       100
                  ....*....|....*....|....*..
gi 1011946562 113 GGELPVASTLVSESVPAQERGKAVVLL 139
Cdd:cd17503   285 GLVFMPLNTLALNSLPPEQIGDATALF 311
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
264-388 2.34e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 39.67  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 264 GYFSAAWLIERAGRKFVLITYLIGTAVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAYTPELYPTSIRGTGAGMAA 343
Cdd:TIGR00881  46 SKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWN 125
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1011946562 344 SFGRIGGILGPLFVGYLVNRHITITTIFLI-FCISIFIGVIAVWVL 388
Cdd:TIGR00881 126 CSHNVGGGLLPPLVLFGIAELYSWHWVFIVpGIIAIIVSLICFLLL 171
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
30-197 2.91e-03

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 39.43  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  30 SFIIAALQKDWN----LSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLR 105
Cdd:cd17434    22 SPVIPALEQGDDprlhLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGR 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 106 FLIGMGLGGELPVASTLVSESVPAQERGkavvLLESFWAVGWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRWGLP 185
Cdd:cd17434   102 FLTGFAGGITAASIPVYVSEISHPGVRG----ALGACPQIMAVFGSLALYALGLLLPWRWLAVAGEVPVVIMILLLCFMP 177
                         170
                  ....*....|..
gi 1011946562 186 DSPRFTSARKEE 197
Cdd:cd17434   178 NSPRFLISKGKD 189
PRK03699 PRK03699
putative transporter; Provisional
32-325 3.17e-03

putative transporter; Provisional


Pssm-ID: 235151 [Multi-domain]  Cd Length: 394  Bit Score: 39.52  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  32 IIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMG 111
Cdd:PRK03699   29 VMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMILAVAGLMFSHSLALFSIAMFVLGVV 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 112 LGGELPVASTLVSESVPAQERGKAVVLLESFWAV-GWLLSALISYFVIPTYGWQTALLLAAIPALYALYLRWGLPDSPRF 190
Cdd:PRK03699  109 SGITMSIGTFLITHVYEGKQRGSRLLFTDSFFSMaGMIFPIIAAYLLARSIEWYWVYACIGLVYVAIFILTLFSEFPALG 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 191 TSARKEETvwdnivkvwSSSYRKETFMLWVL---WFCVVFSYYGMFLWLPSVMVMK-GFSLIKSFEYVLIMTLAQLPGYF 266
Cdd:PRK03699  189 KHAPKADK---------PVAKEKWGIGVLFLaiaALLYILAQLTFISWVPEYAQKKfGMSLEDAGNLVSNFWMAYMVGMW 259
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562 267 SAAWLIERAG-RKFVLITYLIGTaVSAYFFGNADSLALLMTFGILLSFFNLGAWGALYAY 325
Cdd:PRK03699  260 IFSFIVRFFDlQRILTVLAGLAL-VLMYLFVNTDDPSHLLYAILGLGFFSSAIYTTIITL 318
PLN00028 PLN00028
nitrate transmembrane transporter; Provisional
32-112 3.68e-03

nitrate transmembrane transporter; Provisional


Pssm-ID: 177665 [Multi-domain]  Cd Length: 476  Bit Score: 39.14  E-value: 3.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  32 IIAALQKDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMG 111
Cdd:PLN00028   58 LLPIIRDNLNLTKSDIGNAGIASVSGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFS 137

                  .
gi 1011946562 112 L 112
Cdd:PLN00028  138 L 138
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
40-134 4.29e-03

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 39.24  E-value: 4.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  40 WNLSVeqmgwigSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVL---RFLIGMGLGGEL 116
Cdd:cd17431    52 WSLSV-------AIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLSKLAKSYEMLilgRFIIGLYCGLTT 124
                          90
                  ....*....|....*...
gi 1011946562 117 PVASTLVSESVPAQERGK 134
Cdd:cd17431   125 GLVPMYIGEISPTALRGA 142
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
48-164 4.31e-03

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 39.13  E-value: 4.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  48 GWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLTAFLVLRFLIGMGLGGELPVASTLVSESV 127
Cdd:PRK09874  261 GMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNS 340
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1011946562 128 PAQERGKAVVLLESFWAVGWLLSALISYFVIPTYGWQ 164
Cdd:PRK09874  341 SNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFR 377
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
38-127 4.47e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 39.13  E-value: 4.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011946562  38 KDWNLSVEQMGWIGSINSIGMAVGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTT--TLTAFLVLRFLIGMGLGGE 115
Cdd:cd17332   249 KYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpgNLVLILVLAVLAGIGYGGA 328
                          90
                  ....*....|..
gi 1011946562 116 LPVASTLVSESV 127
Cdd:cd17332   329 NLLPWAMLADVI 340
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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