|
Name |
Accession |
Description |
Interval |
E-value |
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
11-388 |
7.66e-154 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 439.10 E-value: 7.66e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 11 LHLDSLLAHGGGGFDAATGAVVPPIQTATTFVRDETYEL------VNPGHIYSRDDN----ALfkktEKLIAALEGGEDS 80
Cdd:COG0626 1 MGPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALaarfagEEGGYIYSRYGNptrrAL----EEALAALEGGEAA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 81 RLFASGMA-AVAAVARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIAvTRPDLVWLEVPSNP 159
Cdd:COG0626 77 LAFASGMAaISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIR-PNTKLVFLETPSNP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 160 FLKVADIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTDNAgsEAWAFLTEERK 239
Cdd:COG0626 156 TLEVVDIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDE--ELAERLRFLQN 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 240 LAGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTgGFGSLMSIQVKG 319
Cdd:COG0626 234 ALGAVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMS-GFGGMLSFELKG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011638920 320 DKTAALNVTGALDLFQRATSLGGTESLVEHRFTI--------EGEGSGIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:COG0626 313 GREAARRFLDALKLFTLAVSLGGVESLITHPATMthrslppeERAALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
29-385 |
1.51e-125 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 366.53 E-value: 1.51e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 29 GAVVPPIQTATTFVRDE------TYELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMA-AVAAVARIVKPGG 101
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSpaeaadLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAaISTVLLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 102 TLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIAvTRPDLVWLEVPSNPFLKVADIKNIANQCKQADALLA 181
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIK-PETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 182 VDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTDnaGSEAWAFLTEERKLAGAVLGSFETWLLLRGLRTLA 261
Cdd:cd00614 160 VDNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGS--GEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 262 LRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTgGFGSLMSIQVKGDKTAALNVTGALDLFQRATSLG 341
Cdd:cd00614 238 LRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMS-GYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLG 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1011638920 342 GTESLVEHRFT--------IEGEGSGIPENLLRLSIGIEHCDDLIADMEQAL 385
Cdd:cd00614 317 GVESLVEHPASmthsqlppEERAAAGITPGLVRLSVGIEDVEDLIADLEQAL 368
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
14-385 |
1.33e-119 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 351.54 E-value: 1.33e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 14 DSLLAHGGGGFDAATGAVVPPIQTATTFVRDetYELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAAV 93
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVFD--FAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAITAA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 94 AR-IVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIAVtRPDLVWLEVPSNPFLKVADIKNIANQ 172
Cdd:pfam01053 79 ILaLLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKP-NTKAVYLETPTNPLLKVVDIEAIAKL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 173 CKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTdnaGSEAWAflTEERKL---AGAVLGSFE 249
Cdd:pfam01053 158 AKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVV---NGEELG--KELYFLqnaTGAVLSPFD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 250 TWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTgGFGSLMSIQVKGDKTAALNVTG 329
Cdd:pfam01053 233 AWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMK-GFGGMLSFELKGGLEAAKKFLD 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011638920 330 ALDLFQRATSLGGTESLVEH--RFTIEG------EGSGIPENLLRLSIGIEHCDDLIADMEQAL 385
Cdd:pfam01053 312 NLKLFSLAVSLGGVESLISHpaTMTHASippeerEAAGITDDLIRLSVGIEDVDDLIADLKQAL 375
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
12-387 |
2.48e-111 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 330.84 E-value: 2.48e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 12 HLDSLLAHGGGGFDAATGAVVPPIQTATTFVRDETYELVNpGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVA 91
Cdd:PRK07811 12 GFATRAIHAGYEPDPATGAVNPPIYASSTFAQDGVGGLRG-GYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGMAATD 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 92 AVARIV-KPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIAvTRPDLVWLEVPSNPFLKVADIKNIA 170
Cdd:PRK07811 91 CLLRAVlRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAIT-PRTKLIWVETPTNPLLSITDIAALA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 171 NQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGG-VVTTDNAGSEAWAFLteeRKLAGAVLGSFE 249
Cdd:PRK07811 170 ELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGaLVTNDEELDEAFAFL---QNGAGAVPGPFD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 250 TWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMtGGFGSLMSIQVKGDKTAALNVTG 329
Cdd:PRK07811 247 AYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQM-RGFGGMVSVRLAGGEEAARDFCA 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011638920 330 ALDLFQRATSLGGTESLVEH--RFT---IEGEGSGIPENLLRLSIGIEHCDDLIADMEQALTA 387
Cdd:PRK07811 326 RTKVFTLAESLGGVESLIEHpsAMThasTAGSQLEVPDDLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
29-388 |
3.65e-91 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 279.70 E-value: 3.65e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 29 GAVVPPIQTATTFVR---DETYELV---NPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAA-VAAVARIVKPGG 101
Cdd:PRK08249 25 GATQVPVVLSVAYGYddiDEWYDVAlgkKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFSTGMAAiSNTLYTFLKPGD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 102 TLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIAvTRPDLVWLEVPSNPFLKVADIKNIANQCKQADALLA 181
Cdd:PRK08249 105 RVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIA-KGCDLLYLETPTNPTLKIVDIERLAAAAKKVGALVV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 182 VDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVttdnAGSEAwafLTEE----RKLAGAVLGSFETWLLLRGL 257
Cdd:PRK08249 184 VDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVV----CGSKE---LMEQvyhyREINGATMDPMSAYLILRGM 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 258 RTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTgGFGSLMSIQVKGDKTAALNVTGALDLFQRA 337
Cdd:PRK08249 257 KTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMR-GFGGILSFVLKGGMDTVKRLLPKLRYAHRA 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1011638920 338 TSLGGTESLV-EHRFTIEGEGS-------GIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK08249 336 ANLGAVETIYgPARTTSHVENTleeraalGIPEGLVRISVGIEDTEDLIADLEQAFAHL 394
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
29-388 |
2.00e-90 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 277.33 E-value: 2.00e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 29 GAVVPPIQTATTFVRDETYELVNPGHI--YSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAAV-ARIVKPGGTLLA 105
Cdd:PRK08574 18 GSLQPPIYLTALFRQEGEAYPSDRGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLfFSLLKAGDRVVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 106 QSGIYwGTTLFLRKMCARNNIALVEAdASDLQSFQDEIAVTRPDLVWLEVPSNPFLKVADIKNIANQCKQADALLAVDAT 185
Cdd:PRK08574 98 PMEAY-GTTLRLLKSLEKFGVKVVLA-YPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEVAKAAKELGAILVVDNT 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 186 AATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTdnAGSEAWAFLTEERKLAGAVLGSFETWLLLRGLRTLALRVE 265
Cdd:PRK08574 176 FATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVA--WSGEFLEELWEWRRRLGTIMQPFEAYLVLRGLKTLEVRFE 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 266 RMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTGG-FGSLMSIQVKGDKTAALNVTGALDLFQRATSLGGTE 344
Cdd:PRK08574 254 RQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKDlYGGVVSFRVKGGRDAVLKFLRSLKLIKPSPSLGGVE 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1011638920 345 SLVEHRF-----TIEGEGS---GIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK08574 334 SLATYPVksaasPIPEEDRkalGITEDLVRLSVGLEDVEDLIEDLDQALGSI 385
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
9-388 |
4.81e-89 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 274.98 E-value: 4.81e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 9 HGLHLDSLLAHGGGGFDAATGAVVPPI-QTaTTFVRDET------YELVNPGHIYSRDDN----ALfkktEKLIAALEGG 77
Cdd:COG2873 4 KKYGFETLALHAGQEPDPTTGARAVPIyQT-TSYVFDDAehaadlFALKEPGNIYTRIMNpttdVL----EKRIAALEGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 78 EDSRLFASGMA-AVAAVARIVKPGGTLLAQSGIYWGT-TLF---LRKMcarnNIALVEADASDLQSFQDEIavtRPD--L 150
Cdd:COG2873 79 VAALATASGQAaITLAILNLAEAGDHIVASSSLYGGTyNLFahtLPRL----GIEVRFVDPDDPEAFEAAI---DPNtkA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 151 VWLEVPSNPFLKVADIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVV----TTDNA 226
Cdd:COG2873 152 IFGETIGNPALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIvdggNFDWA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 227 GSEAWAFLTEER-------------KLA-------------GAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEK 280
Cdd:COG2873 232 ANGKFPELTEPDpsyhglvyteafgNAAfitkarvqllrdlGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 281 HPKVEAVLYPGVKSHPHHELAKSQMTGGFGSLMSIQVKGDKTAALNVTGALDLFQRATSLGGTESLVEH-------RFTI 353
Cdd:COG2873 312 HPKVAWVNYPGLPSHPYHELAQKYLPKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHpastthsQLSE 391
|
410 420 430
....*....|....*....|....*....|....*.
gi 1011638920 354 EG-EGSGIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:COG2873 392 EEqAAAGVTPDLIRLSVGIEDIDDIIADLDQALAAA 427
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
11-388 |
1.49e-87 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 269.85 E-value: 1.49e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 11 LHLDSLLAHGGGGFDAATGAVVPPIQTATTFVRDETYElvNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAV 90
Cdd:PRK06176 1 MRMQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGR--PKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 91 AAVARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIavtRPDL--VWLEVPSNPFLKVADIKN 168
Cdd:PRK06176 79 HAVFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAI---KPNTkaLYLETPSNPLLKITDLAQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 169 IANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTDN-AGSEAWAFLteeRKLAGAVLGS 247
Cdd:PRK06176 156 CASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNeALAQEIAFF---QNAIGGVLGP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 248 FETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTgGFGSLMSIQVKGDkTAALNV 327
Cdd:PRK06176 233 QDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMR-GFSGMLSFTLKND-SEAVAF 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1011638920 328 TGALDLFQRATSLGGTESLVE------HRF--TIEGEGSGIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK06176 311 VESLKLFILGESLGGVESLVGipafmtHACipKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 379
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
22-388 |
8.40e-86 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 264.94 E-value: 8.40e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 22 GGFDAATGA-VVPPIQTATTF--VRDETyelvNPGHIYSRDDNALFKKTEKLIAALEGGEdSRLFASGMAAVAAVAR-IV 97
Cdd:PRK07582 12 GGPEAVPGEpVLPGPVFAAPYhlSPGEP----TGPDTYGRASNPTWRALEAALGELEGAE-ALVFPSGMAAITAVLRaLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 98 KPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQsfqdEIAVTRPDLVWLEVPSNPFLKVADIKNIANQCKQAD 177
Cdd:PRK07582 87 RPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTAGMA----EAALAGADLVLAETPSNPGLDVCDLAALAAAAHAAG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 178 ALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTDNAgsEAWAFLTEERKLAGAVLGSFETWLLLRGL 257
Cdd:PRK07582 163 ALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDP--ELMAAVERWRLLAGAIPGPFEAWLAHRSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 258 RTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTgGFGSLMSIQVkGDKTAALNVTGALDLFQRA 337
Cdd:PRK07582 241 GTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMR-RFGGLVSFEL-ADAAAAERFVAASRLVVAA 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1011638920 338 TSLGGTESLVEHRftiEGEGSGIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK07582 319 TSFGGVHTSADRR---ARWGDAVPEGFVRLSCGIEDTDDLVADLERALDAL 366
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
15-385 |
1.85e-82 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 256.57 E-value: 1.85e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 15 SLLAHGGGGFDAATGAVVPPIQTATTFVRDETYElvNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAAVA 94
Cdd:PRK07671 5 TKLIHGGIIGDPSTGAVSVPIYQVSTYKQEAVGK--HQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 95 RIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIavtRPD--LVWLEVPSNPFLKVADIKNIANQ 172
Cdd:PRK07671 83 MLFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAI---RPNtkAIYVETPTNPLLKITDIKKISTI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 173 CKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGG-VVTTDNAGSEAWAFLTEErklAGAVLGSFETW 251
Cdd:PRK07671 160 AKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGlVVVNSPELAEDLHFVQNS---TGGILGPQDSW 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 252 LLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTgGFGSLMSIQVkGDKTAALNVTGAL 331
Cdd:PRK07671 237 LLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQAN-GFGGMISFDV-GSEETANKVLERL 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1011638920 332 DLFQRATSLGGTESL--VEHRFT---IEGEGS---GIPENLLRLSIGIEHCDDLIADMEQAL 385
Cdd:PRK07671 315 QYFTLAESLGAVESLisIPSQMThasIPADRRkelGITDGLIRISVGIEDGEDLIEDLAQAL 376
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
19-388 |
2.35e-82 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 257.06 E-value: 2.35e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 19 HGGGGFDAATGAVVPPIQTATTFVRDET------YELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAA 92
Cdd:PRK06234 15 HGGHIGDKQFGSLATPIYQTSTFIFDSAeqggrrFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMGAISS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 93 VA-RIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEI-AVTRpdLVWLEVPSNPFLKVADIKNIA 170
Cdd:PRK06234 95 SLwSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALkANTK--VVYLETPANPTLKVTDIKAIS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 171 N--QCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTDNAGSEAWAFLTEeRKLAGAVLGSF 248
Cdd:PRK06234 173 NiaHENNKECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKEEFINQVKLFGI-KDMTGSVIGPF 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 249 ETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTgGFGSLMSIQVKGDKTAALNVT 328
Cdd:PRK06234 252 EAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMS-LPGAMISFELKGGVEEGKVVM 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1011638920 329 GALDLFQRATSLGGTESLVEHRFTI--------EGEGSGIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK06234 331 NNVKLATLAVSLGDAETLIQHPASMthspytaeERKEAGISDGLVRLSVGLEDVDDIIADLKQALDLI 398
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
8-388 |
3.53e-81 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 253.93 E-value: 3.53e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 8 AHGLHLDSLLAHGGGGFDAATGAVVPPIQTATTFVRDE-----TYElvnpghiYSRDDNALFKKTEKLIAALEGGEDSRL 82
Cdd:PRK08064 2 AMSYSIDTLLLHNQYKHDKQTGAVNVPIYHASTFHQFDfdtfgKYD-------YSRSGNPTREALEDIIAELEGGTKGFA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 83 FASGMAAVAAVARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIavtRPD--LVWLEVPSNPF 160
Cdd:PRK08064 75 FASGMAAISTAFLLLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNI---KPNtkLFYVETPSNPL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 161 LKVADIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGV-VTTDNAGSEAWAFLteeRK 239
Cdd:PRK08064 152 LKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLaVVKDEELAQKLYFL---QN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 240 LAGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTgGFGSLMSIQVkG 319
Cdd:PRK08064 229 SFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQAT-SAGAVLSFTL-Q 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011638920 320 DKTAALNVTGALDLFQRATSLGGTESLVEHRFTI--------EGEGSGIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK08064 307 SEEAVRQFVSHVKLPVFAVSLGAVESILSYPAKMshaampkeERDERGITDGLLRLSVGLENVDDLIADFEQALSYV 383
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
29-388 |
9.73e-81 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 252.89 E-value: 9.73e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 29 GAVVPPIQTATTFVRD------ETYELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAA-VAAVARIVKPGG 101
Cdd:TIGR01328 20 GALTPPIYQTSTFVFDsceqggNRFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSGMGAiAATLLTILKAGD 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 102 TLLAQSGIYWGTTLFLRKMCARNNIalvEADASDLQSFQDEIAVTRPD--LVWLEVPSNPFLKVADIKNIANQCKQADAL 179
Cdd:TIGR01328 100 HLISDECLYGCTFALLEHALTKFGI---QVDFINMAIPEEVKAHIKDNtkIVYFETPANPTMKLIDMERVCRDAHSQGVK 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 180 LAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTDnAGSEAWAFLTEERKLAGAVLGSFETWLLLRGLRT 259
Cdd:TIGR01328 177 VIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGK-AELLQQIRMVGIKDMTGSVISPFDAWLILRGLKT 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 260 LALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTGGfGSLMSIQVKGDKTAALNVTGALDLFQRATS 339
Cdd:TIGR01328 256 LNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMG-GGMITFELKGGFAGAKKLLNNLKLIRLAVS 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1011638920 340 LGGTESLVEHRFTI--------EGEGSGIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:TIGR01328 335 LGDAETLIQHPASMthavvpkeEREAAGITDGMIRLSVGLEDADDLIADLKQALDAL 391
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
23-387 |
2.22e-79 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 249.72 E-value: 2.22e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 23 GFDAAT--GAVVPPIQTATTFVRD------ETYELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAAVA 94
Cdd:PRK07503 18 GYDPLDhgGALVPPVYLTATFAFPtaeygaECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASGMGAITATL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 95 -RIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIA-VTRpdLVWLEVPSNPFLKVADIKNIANQ 172
Cdd:PRK07503 98 wTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISdKTR--MVYFETPANPNMRLVDIAAVAEI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 173 CKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTDNAGSEAwAFLTEERKLAGAVLGSFETWL 252
Cdd:PRK07503 176 AHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADR-IRLEGLKDMTGAVMSPFDAFL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 253 LLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTGGfGSLMSIQVKGDKTAALNVTGALD 332
Cdd:PRK07503 255 LMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALP-GGMIAFELKGGIAAGRRFMNALQ 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011638920 333 LFQRATSLGGTESLVEHRFTI--------EGEGSGIPENLLRLSIGIEHCDDLIADMEQALTA 387
Cdd:PRK07503 334 LFARAVSLGDAESLAQHPASMthstytpeERAEHGISEGLVRLSVGLEDVADILADLAQALDA 396
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
52-387 |
5.87e-79 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 247.99 E-value: 5.87e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 52 PGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAA-VAAVARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVE 130
Cdd:PRK08133 51 PGNIYSRFTNPTVTMFQERLAALEGAEACVATASGMAAiLAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTF 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 131 ADASDLQSFQdeiAVTRPD--LVWLEVPSNPFLKVADIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATK 208
Cdd:PRK08133 131 VDLTDLDAWR---AAVRPNtkLFFLETPSNPLTELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATK 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 209 ALNGHSDLLGGVVTTDNAG-SEAWAFLteerKLAGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAV 287
Cdd:PRK08133 208 YLDGQGRVLGGAVVGSKELmEEVFGFL----RTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERV 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 288 LYPGVKSHPHHELAKSQMTgGFGSLMSIQVKGDKTAALNVTGALDLFQRATSLGGTESLVEH-------RFTIEG-EGSG 359
Cdd:PRK08133 284 FYPGLPSHPQHELAKRQQK-GGGAIVSFEVKGGREAAWRVIDATRLISITANLGDTKTTITHpattthgRLSPEArAAAG 362
|
330 340
....*....|....*....|....*...
gi 1011638920 360 IPENLLRLSIGIEHCDDLIADMEQALTA 387
Cdd:PRK08133 363 ITEGLIRVAVGLEDVADIKADLARGLAA 390
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
13-387 |
6.33e-79 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 247.43 E-value: 6.33e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 13 LDSLLAHGGGGFDAaTGAVVPPIQTATTFVRDETYElvNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAA 92
Cdd:TIGR01329 1 LSTLLVNTDNKNDP-YDASSMPIYQTATFKQPLAIE--NGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 93 VARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIaVTRPDLVWLEVPSNPFLKVADIKNIANQ 172
Cdd:TIGR01329 78 ITRLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAAL-GPKTKLVLLESPTNPLQKIVDIRKISEM 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 173 CKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGV--VTTDNAGSEAwAFLTEERklaGAVLGSFET 250
Cdd:TIGR01329 157 AHAQNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVlaVKGEEIAKKV-YFLQNST---GSGLAPFDC 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 251 WLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQmTGGFGSLMSIQVkGDKTAALNVTGA 330
Cdd:TIGR01329 233 WLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQ-AKGAGSVLSFET-GSVALSKRLVEA 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011638920 331 LDLFQRATSLGGTESLVE-----HRFTIEG---EGSGIPENLLRLSIGIEHCDDLIADMEQALTA 387
Cdd:TIGR01329 311 TKLFSITVSFGSVNSLISmpcfmSHASIPAevrEERGLPEDLVRLSVGIEDVDDLISDLDIAFVT 375
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
12-385 |
6.89e-79 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 248.81 E-value: 6.89e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 12 HLDSLLAHGGGGFDAATGAVVPPIQTATTFVRDET------YELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFAS 85
Cdd:TIGR01326 1 HFETLQLHAGQEPDPTTGSRAVPIYQTTSYVFDSTehaaalFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 86 GMAAVAAV-ARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQdeiAVTRPD--LVWLEVPSNPFLK 162
Cdd:TIGR01326 81 GQAAITYAiLNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLE---KAIDENtkAVFAETIGNPQIN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 163 VADIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTtdNAGSEAW----------- 231
Cdd:TIGR01326 158 VLDIEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIV--DGGKFDWnngrfplfttp 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 232 ----------------AFLTEER----KLAGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPG 291
Cdd:TIGR01326 236 dpsyhglvftetlgnpAFILKARvqllRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 292 VKSHPHHELAKSQMTGGFGSLMSIQVKGDKTAALNVTGALDLFQRATSLGGTESLVEHRFTI--------EGEGSGIPEN 363
Cdd:TIGR01326 316 LASHPHHALAKKYLPKGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTthsqlseeEQLKAGVTPG 395
|
410 420
....*....|....*....|..
gi 1011638920 364 LLRLSIGIEHCDDLIADMEQAL 385
Cdd:TIGR01326 396 LIRLSVGIENIDDIIADLEQAL 417
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
25-387 |
5.57e-76 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 240.18 E-value: 5.57e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 25 DAATGAVVPPIQTATTFvrdETYELVNP-GHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAAVARI-VKPGGT 102
Cdd:PRK08045 17 DEQYGCVVPPIHLSSTY---NFTGFNEPrAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVfLKPGDL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 103 LLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIAvTRPDLVWLEVPSNPFLKVADIKNIANQCKQADALLAV 182
Cdd:PRK08045 94 LVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALA-EKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 183 DATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTT---DNAGSEAWAflteeRKLAGAVLGSFETWLLLRGLRT 259
Cdd:PRK08045 173 DNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAkdpDVVTELAWW-----ANNIGVTGGAFDSYLLLRGLRT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 260 LALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTgGFGSLMSIQVKGDKTAALNVTGALDLFQRATS 339
Cdd:PRK08045 248 LVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQK-GFGAMLSFELDGDEQTLRRFLGGLSLFTLAES 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1011638920 340 LGGTESLVEHRFTIEGEG--------SGIPENLLRLSIGIEHCDDLIADMEQALTA 387
Cdd:PRK08045 327 LGGVESLISHAATMTHAGmapearaaAGISETLLRISTGIEDGEDLIADLENGFRA 382
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
23-388 |
3.33e-75 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 237.81 E-value: 3.33e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 23 GFDAATGAVVPPIQTATTFV--RDETYElvnpghiYSRDDNALFKKTEKLIAALEGGEDSRLFASGM-AAVAAVARIVKP 99
Cdd:PRK06460 11 DIDEATGAITTPIYQTTAYHypEGEKYR-------YSREANPTVLELTKKIVELENAEMGVAFSSGMgAISTTALALLKP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 100 GGTLLAQSGIYwGTTLFLRKMCARNNIALVEADASDLQSFQDEIAVTRPDLVWLEVPSNPFLKVADIKNIANQCKQADAL 179
Cdd:PRK06460 84 GNSVLVHRDMF-GRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 180 LAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVttdnAGS-EAWAFLTEERKLAGAVLGSFETWLLLRGLR 258
Cdd:PRK06460 163 LIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLA----AGYgKLLNVIDQMRRTLGTSLDPHAAYLTLRGIK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 259 TLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKsQMTGGFGSLMSIQVKGDKTAALNVTGALDLFQRAT 338
Cdd:PRK06460 239 TLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIAR-RVLKGFGGVLSFEVNGGQESALKVMKSLKLIIPAQ 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1011638920 339 SLGGTESLVEHRFTI--------EGEGSGIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK06460 318 TLGGVNSVISHPATMshrtlsleERKIVGITDSLLRLSVGIEDVNDLIEDLDRALSTL 375
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
12-388 |
5.92e-75 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 236.91 E-value: 5.92e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 12 HLDSLLAHGGGGFDAATGAVVPPIQTATTFVRDETYElvNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVA 91
Cdd:PRK08247 4 TIETKLAQIGNRSDERTGTVNPPVYFSTAYRHEGIGE--STGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 92 AVARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQsfQDEIAVT-RPDLVWLEVPSNPFLKVADIKNIA 170
Cdd:PRK08247 82 LVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLK--AIEQAITpNTKAIFIETPTNPLMQETDIAAIA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 171 NQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTDnaGSEAWAFLTEERKLAGAVLGSFET 250
Cdd:PRK08247 160 KIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAK--GQELCERLAYYQNAAGAVLSPFDS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 251 WLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVkshphhelaksqmtggfGSLMSIQVKgDKTAALNVTGA 330
Cdd:PRK08247 238 WLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYPGR-----------------GGMLSFRLQ-DEEWVNPFLKS 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011638920 331 LDLFQRATSLGGTESLVEHRFT-----IEGE---GSGIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK08247 300 LKLITFAESLGGVESFITYPATqthadIPEEiriANGVCNRLLRFSVGIENVEDLIADLKQAFKQV 365
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
12-388 |
2.81e-73 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 233.19 E-value: 2.81e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 12 HLDSLLAHGGGGFDAATGAVVPPI-QTAT-TFVRDE----TYELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFAS 85
Cdd:PRK06767 5 HMETALIHHGYTSEEHKGSLTPPLfQTSTfTFETAQqgeaSFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAFGS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 86 GMAAVAAV-ARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIalvEADASDLQSFQDEIAVTRPD--LVWLEVPSNPFLK 162
Cdd:PRK06767 85 GMAAISATlIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMI---THSFCDMETEADIENKIRPNtkLIFVETPINPTMK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 163 VADIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTDnagSEAWAFLTEE-RKLA 241
Cdd:PRK06767 162 LIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICK---TRALAEKIRPmRKDI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 242 GAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYpgvkshPHHELAKSQMTGGfGSLMSIQVKGDK 321
Cdd:PRK06767 239 GGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRG-GGVISFSIKGGK 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011638920 322 TAALNVTGALDLFQRATSLGGTESLVEHRFTI--------EGEGSGIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK06767 312 EETQAFINDLHFITIAVSLGDTETLIQHPATMthaaipaeLRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKKI 386
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
51-388 |
2.80e-68 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 220.78 E-value: 2.80e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 51 NPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAAVARI-VKPGGTLLAQSGIYWGTTLFLRKMCARNNIALV 129
Cdd:PRK07504 54 DPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTAAILCqVKAGDHVVAARALFGSCRYVVETLLPRYGIEST 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 130 EADASDLQSFQDEIavtRPD--LVWLEVPSNPFLKVADIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSAT 207
Cdd:PRK07504 134 LVDGLDLDNWEKAV---RPNtkVFFLESPTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSAT 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 208 KALNGHSDLLGGVVTTDNagseawAFLTEERKL----AGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPK 283
Cdd:PRK07504 211 KHIDGQGRCLGGVVLSDK------AWIEEHLQDyfrhTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPK 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 284 VEAVLYPGVKSHPHHELAKSQMTGGfGSLMSIQVKGDKTAALNVTGALDLFQRATSLGGTESLVEH-------RFTIEGE 356
Cdd:PRK07504 285 VARVIYPGRADHPQADIIAKQMTGG-STLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHpattthkNLSPEAR 363
|
330 340 350
....*....|....*....|....*....|...
gi 1011638920 357 GS-GIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK07504 364 AElGISEGFLRLSAGLEDTDDLIEDLAAALKKV 396
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
14-387 |
6.89e-68 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 220.77 E-value: 6.89e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 14 DSLLAHGGGGFDAATGAVVPPIQTATTFVRDET------YELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGM 87
Cdd:PRK08134 10 DTLALHAGAAPDPATGARAVPIHLTTSFVFRDSdhaaalFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATASGQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 88 AAVAAV-ARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIavtRPD--LVWLEVPSNPFLKVA 164
Cdd:PRK08134 90 AALHLAiATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAI---RPNtrLLFGETLGNPGLEVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 165 DIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTtdNAGSEAW------------- 231
Cdd:PRK08134 167 DIPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLV--DGGRFDWeasgkfpeltepy 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 232 ---------------AFLTEERKLA----GAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGV 292
Cdd:PRK08134 245 agfhgmvfaeestvaAFLLRARREGlrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPEL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 293 KSHPHHELAKSQMTGGFGSLMSIQVKGDKTAALNVTGALDLFQRATSLGGTESLVEH-------RFTIEG-EGSGIPENL 364
Cdd:PRK08134 325 ESHPDHALAKRLLPRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHpastthfRMDAAAlAAAGIGEGT 404
|
410 420
....*....|....*....|...
gi 1011638920 365 LRLSIGIEHCDDLIADMEQALTA 387
Cdd:PRK08134 405 IRLSIGLEDADDLIDDLKRALKA 427
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
25-385 |
1.19e-67 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 219.48 E-value: 1.19e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 25 DAATGAVVPPIQTATTFVRD-----ETYElvnpghiYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAAVAR-IVK 98
Cdd:PRK08776 25 DTAYGAVTPPIVLSSNFSFDgfgnkRQYD-------YTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNaLLQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 99 PGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIAvTRPDLVWLEVPSNPFLKVADIKNIANQCKQADA 178
Cdd:PRK08776 98 PGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALA-QSPKLVLIETPSNPLLRITDLRFVIEAAHKVGA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 179 LLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGG-VVTTDNAGSEAWAFLTEERKLAGAvlgSFETWLLLRGL 257
Cdd:PRK08776 177 LTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGaVVARDAELHQQLVWWANALGLTGS---PFDAFLTLRGL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 258 RTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTgGFGSLMSIQVKGDKTAALNVTGALDLFQRA 337
Cdd:PRK08776 254 RTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQK-GFGAMLSFELEGGEAAVRAFVDGLRYFTLA 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1011638920 338 TSLGGTESLVEH-------RFTIEGEG-SGIPENLLRLSIGIEHCDDLIADMEQAL 385
Cdd:PRK08776 333 ESLGGVESLIAHpasmthaAMTAEARAaAGISDGLLRLSVGIESAEDLLIDLRAGL 388
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
30-385 |
1.29e-67 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 221.06 E-value: 1.29e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 30 AVVPPIQTATTFVRDETYElvNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAAVARIVKPGGTLLAQSGI 109
Cdd:PLN02509 103 AMSTPLYQTATFKQPSAIE--NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDV 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 110 YWGTTLFLRKMCARNNIALVEADASDLqsfqDEIAVT---RPDLVWLEVPSNPFLKVADIKNIANQCKQADALLAVDATA 186
Cdd:PLN02509 181 YGGSDRLLSQVVPRSGVVVKRVNTTNL----DEVAAAigpQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNSI 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 187 ATPLILKPLSLGADLVMHSATKALNGHSDLLGGV--VTTDNAGSEAWAFLTEErklaGAVLGSFETWLLLRGLRTLALRV 264
Cdd:PLN02509 257 MSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVlaVKGEKLAKEVYFLQNSE----GSGLAPFDCWLCLRGIKTMALRI 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 265 ERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTGGfGSLMSIqVKGDKTAALNVTGALDLFQRATSLGGTE 344
Cdd:PLN02509 333 EKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGA-GSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVK 410
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1011638920 345 SLVE-----HRFTIEG---EGSGIPENLLRLSIGIEHCDDLIADMEQAL 385
Cdd:PLN02509 411 SLISmpcfmSHASIPAevrEARGLTEDLVRISAGIEDVDDLISDLDIAF 459
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
25-386 |
1.31e-65 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 213.60 E-value: 1.31e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 25 DAATGAVVPPIQTATTFVRDETYELvnPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAA-VARIVKPGGTL 103
Cdd:PRK08861 18 DSQYHAVVPPIYLSTNYGFPAFGEV--PKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLwVSALLGPDDLI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 104 LAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIAvTRPDLVWLEVPSNPFLKVADIKNIANQCKQADALLAVD 183
Cdd:PRK08861 96 VAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALA-KKPKLILLETPSNPLVRVVDIAELCQKAKAVGALVAVD 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 184 ATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVV---TTDNAGSEAWAflteeRKLAGAVLGSFETWLLLRGLRTL 260
Cdd:PRK08861 175 NTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLitkTKEHAEELAWW-----GNCIGATGTPFDSYMTLRGIRTL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 261 ALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTgGFGSLMSIQVKGDKTAALNVTGALDLFQRATSL 340
Cdd:PRK08861 250 GARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQS-GFGSMLSFEFAGSFEQLKVFVKALALFSLAESL 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1011638920 341 GGTESLVEHRFTIEGEG--------SGIPENLLRLSIGIEHCDDLIADMEQALT 386
Cdd:PRK08861 329 GGVESLICHPASMTHRAmgeealaeAGVSQQLLRLSVGLEDAQDLIADLDQAFA 382
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
11-387 |
8.80e-64 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 208.14 E-value: 8.80e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 11 LHLDSLLAHGGGGFDAATGAVVPPIQTATTFVRDETYElvNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAV 90
Cdd:PRK07269 5 LHINTILAQAGIKSDEATGALVTPLHFSTTYQHPEFGQ--STGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 91 AAVARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASD--LQSFQDEIavtrpDLVWLEVPSNPFLKVADIKN 168
Cdd:PRK07269 83 VLAFSVFPVGSKVVAVRDLYGGSFRWFNQQEKEGRFHFTYANTEEelIAAIEEDT-----DIVYIETPTNPLMVEFDIEK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 169 IANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTDNAgsEAWAFLTEERKLAGAVLGSF 248
Cdd:PRK07269 158 VAKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDL--ELYEKLFYNLNTTGAVLSPF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 249 ETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVkshphhelaksqmtggfGSLMSIQVKgDKTAALNVT 328
Cdd:PRK07269 236 DSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK-----------------GGMISFKVA-DETRIPHIL 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011638920 329 GALDLFQRATSLGGTESLVEHRFT-----IEGE---GSGIPENLLRLSIGIEHCDDLIADMEQALTA 387
Cdd:PRK07269 298 NSLKVFTFAESLGGVESLITYPTTqthadIPAEvrhSYGLTDDLLRLSIGIEDARDLIADLKQALEG 364
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
25-387 |
2.16e-63 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 207.83 E-value: 2.16e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 25 DAATGAVVPPIQTATTFV----RDETY--ELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGM-AAVAAVARIV 97
Cdd:PRK06434 21 DPRFGNVTTPIFETSTFVypnsEKEAYmdSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMgAITSAILSLI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 98 KPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFqdEIAVTRPDLVWLEVPSNPFLKVADIKNIANQCKQAD 177
Cdd:PRK06434 101 KKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSL--DFDPSNYDLIYAESITNPTLKVPDIKNVSSFCHEND 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 178 ALlaVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTDNagSEAWAFLTEERKLAGAVLGSFETWLLLRGL 257
Cdd:PRK06434 179 VI--VDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNN--KSIFNNLVERRKTLGSNPDPIQAYLALRGL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 258 RTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVkshphhELAKSQMTgGFGSLMSIQVKGDKTAALNVTGaLDLFQRA 337
Cdd:PRK06434 255 KTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLR-GFGGMLSFELRSMEDVHKFIRN-LEIPMVA 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1011638920 338 TSLGGTESL----VEHRFTI----EGEGSGIPENLLRLSIGIEHCDDLIADMEQALTA 387
Cdd:PRK06434 327 ASLGGVESLitlpVETSHSSlspeERERLGISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
13-388 |
2.21e-63 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 208.80 E-value: 2.21e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 13 LDSLLAHGGGGFDAATGAVVPPIQTATTFVRDET------YELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASG 86
Cdd:PRK05994 8 FATLAVHAGAQPDPTTGARATPIYQTTSFVFNDAdhaaslFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVASG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 87 MAAVAAVAR-IVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFqdEIAVT-RPDLVWLEVPSNPFLKVA 164
Cdd:PRK05994 88 HAAQFLVFHtLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASF--ERAITpRTKAIFIESIANPGGTVT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 165 DIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVV----TTDNAGSEAWAFLTEER-- 238
Cdd:PRK05994 166 DIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIvdggTFDWSKSGKYPMLSEPRpe 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 239 ---------------KLAGAVLG---------SFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKS 294
Cdd:PRK05994 246 yhglvlhetfgnfafAIAARVLGlrdlgpaisPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPD 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 295 HPHHELAKSQMTGGFGSLMSIQVKGDKTAALNVTGALDLFQRATSLGGTESLVEH-------RFTIEGE-GSGIPENLLR 366
Cdd:PRK05994 326 DPYHALAQKYSPKGAGAVFTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHpastthrQLTDEQKvAAGAGPDVVR 405
|
410 420
....*....|....*....|..
gi 1011638920 367 LSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK05994 406 LSIGIEDVDDIIADLEQALAKA 427
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
1-387 |
4.74e-63 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 206.86 E-value: 4.74e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 1 MPKTPSIAHGLHLdsLLAHGGGgfdAATGAVVPPIQTATTFVRDETYEL--------VNPghIYSRDDNALFKKTEKLIA 72
Cdd:PRK05968 1 MNDGLDPFDLAAL--ITAHDEG---NAFDAVVPPIFQTSLFTFDSYDEMedvyagekVRP--IYSRGDNPTVRAFEEMLA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 73 ALEGGEDSRLFASGMAA-VAAVARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDlqsfQDEIAVTRP--D 149
Cdd:PRK05968 74 KLEGAEDARGFASGMAAiSSTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRD----EEAVAKALPgaK 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 150 LVWLEVPSNPFLKVADIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTTDNA--- 226
Cdd:PRK05968 150 LLYLESPTSWVFELQDVAALAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEhia 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 227 --GSEAWAFLteerklaGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAksq 304
Cdd:PRK05968 230 riNAEAYPYL-------GAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGLS--- 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 305 mtgGFGSLMSIQVKGDKTAALNVTgALDLFQRATSLGGTESLV---------------EHRFtiegegsGIPENLLRLSI 369
Cdd:PRK05968 300 ---GTSGLFSFIFREGIDVRAFAD-ALKLFRLGVSWGGHESLVvpaevvlqqkaqpnsAARF-------GVSPRSVRLHV 368
|
410
....*....|....*...
gi 1011638920 370 GIEHCDDLIADMEQALTA 387
Cdd:PRK05968 369 GLEGTEALWADLEQALAA 386
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
11-387 |
1.99e-62 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 206.29 E-value: 1.99e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 11 LHLDSLLAHGGGGFDAATGAVVPPIQTATTFVRDET------YELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFA 84
Cdd:PRK06084 1 MKLETLAIHAGYSPDPTTKAVAVPIYQTTSYAFDDTqhgadlFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 85 SGMAAVAAVAR-IVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIAvTRPDLVWLEVPSNPFLKV 163
Cdd:PRK06084 81 SGMAAITYAIQtIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALID-ERTKAVFCESIGNPAGNI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 164 ADIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTtdNAGSEAW------------ 231
Cdd:PRK06084 160 IDIQALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVV--DSGKFPWaehkerfallnt 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 232 -----------------AFLTEER----KLAGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYP 290
Cdd:PRK06084 238 pdpsyhgvtyteafgpaAFIGRCRvvplRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 291 GVKSHPHHELAKSQMTGGFGSLMSIQVKGDKTAALNVTGALDLFQRATSLGGTESLVEHRFTI--------EGEGSGIPE 362
Cdd:PRK06084 318 GLPDHPEHELARRYMGGKPASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTthrqlndeELEKAGVSR 397
|
410 420
....*....|....*....|....*
gi 1011638920 363 NLLRLSIGIEHCDDLIADMEQALTA 387
Cdd:PRK06084 398 DMVRLSIGIEHIDDIIADLAQALDA 422
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
19-387 |
1.36e-61 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 204.60 E-value: 1.36e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 19 HGGGGFDAATGAVVPPIQTATTFVRDET------YELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAA 92
Cdd:PRK07812 20 HAGQTPDPATNARALPIYQTTSYTFDDTdhaaalFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGVAALLLASGQAAETF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 93 V-ARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNI--ALVEaDASDLQSFQdeiAVTRPD--LVWLEVPSNPFLKVADIK 167
Cdd:PRK07812 100 AiLNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIevSFVE-DPDDLDAWR---AAVRPNtkAFFAETISNPQIDVLDIP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 168 NIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTtdNAGSEAW---------------- 231
Cdd:PRK07812 176 GVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIV--DGGTFDWtqgrfpgfttpdpsyh 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 232 ----------AFLTEER----KLAGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPH 297
Cdd:PRK07812 254 gvvfaelgppAYALKARvqllRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPW 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 298 HELAKSQMTGGFGSLMSIQVKGDKTAALNVTGALDLFQRATSLGGTESLVEHRFTI--------EGEGSGIPENLLRLSI 369
Cdd:PRK07812 334 YERAKRLAPKGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTthsqltpeEQLATGVTPGLVRLAV 413
|
410
....*....|....*...
gi 1011638920 370 GIEHCDDLIADMEQALTA 387
Cdd:PRK07812 414 GIEGIDDILADLEAGFAA 431
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
9-388 |
3.45e-61 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 202.98 E-value: 3.45e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 9 HGLHLDSLLAhgGGGFDAA--TGAVVPPIQTATTFV----------------RDETYELVNPGHIYSRDDNALFKKTEKL 70
Cdd:PRK07049 14 RELHPETQML--NYGYDPElsEGAVKPPVFLTSTFVfrsaedgrdffdyvsgRKEPPAGEGAGLVYSRFNHPNSEIVEDR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 71 IAALEGGEDSRLFASGMAA-VAAVARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVE-ADASDLQSFQDEI----A 144
Cdd:PRK07049 92 LAVYEGAESAALFSSGMSAiATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGAVGfADGLSEAAIGAAAeaaaA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 145 VTRPDLVWLEVPSNP---FLKVADIKNIANQCKQADA---LLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLG 218
Cdd:PRK07049 172 KGRVSLILIETPANPtnsLVDVAAVRRVADAIEARQGhrpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 219 GVVTTDNAgseawaFLTEERKLAGAV---LGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYpgvksH 295
Cdd:PRK07049 252 GAVLGRKA------LIRQVRALRSAIgtqLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHY-----L 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 296 PHHE-------LAKSQMTGGfGSLMSIQVKGDKTAALNVTGALDLFQRATSLGGTESLVEHRFTIEGEG--------SGI 360
Cdd:PRK07049 321 PFLDpdsaygaVYKRQCTGA-GSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGvpadvrerIGV 399
|
410 420
....*....|....*....|....*...
gi 1011638920 361 PENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK07049 400 LESTIRLSIGIEHPDDLIADLAQALDAA 427
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
29-388 |
2.72e-60 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 199.91 E-value: 2.72e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 29 GAVVPPIQTATTFVRDETYELVN------PGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAAVARIVKPGGT 102
Cdd:PRK05939 8 GAVHKPIHTSVTYGYEDARDLIDvfqgkkPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 103 LLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIavtRPD--LVWLEVPSNPFLKVADIKNIANQCKQADALL 180
Cdd:PRK05939 88 HLVSSQFLFGNTNSLFGTLRGLGVEVTMVDATDVQNVAAAI---RPNtrMVFVETIANPGTQVADLAGIGALCRERGLLY 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 181 AVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTT---------DN-------AGSEAWAfLTEERKLA--- 241
Cdd:PRK05939 165 VVDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTDtglfdwsayPNifpayrkGDPQQWG-LTQIRKKGlrd 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 242 -GAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKsQMTGGFGSLMSIQVK-- 318
Cdd:PRK05939 244 mGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARAT-ELFRHYGGLLSFELAdg 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 319 GDKTAALNvtgALDLFQRATSLGGTESL---VEHrfTIEGEGS-------GIPENLLRLSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK05939 323 IDCFDFLN---RLKLVIKATHLGDTRTLvipVAP--TIYYEMGaerrasmGIADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
13-387 |
1.87e-59 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 198.53 E-value: 1.87e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 13 LDSLLAHGGGGFDAATGAVVPPIQTATTFVRDET------YELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASG 86
Cdd:PRK08248 9 LETLAIHAGQEIDPTTGSRAVPIYQTTSYGFRDSehaanlFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVSSG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 87 MAAVA-AVARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIAvTRPDLVWLEVPSNPFLKVAD 165
Cdd:PRK08248 89 QAAITySILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAIT-DKTKALFAETIGNPKGDVLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 166 IKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVV----TTDNAGSEAWAFLTEE---- 237
Cdd:PRK08248 168 IEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIvdsgKFDWKGSGKFPGLTEPdpsy 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 238 -----------------------RKLaGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKS 294
Cdd:PRK08248 248 hglvytdavgeaayitkarvqllRDL-GAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPS 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 295 HPHHELAKSQMTGGFGSLMSIQVKGDKTAALNVTGALDLFQRATSLGGTESLVEHRFTI--------EGEGSGIPENLLR 366
Cdd:PRK08248 327 HPSYELAKKYLPKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTthqqlseeEQLAAGVTPGLVR 406
|
410 420
....*....|....*....|.
gi 1011638920 367 LSIGIEHCDDLIADMEQALTA 387
Cdd:PRK08248 407 LSVGTEAIDDILDDLRQAIRQ 427
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
55-385 |
8.10e-57 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 191.10 E-value: 8.10e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 55 IYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAV-AAVARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIALVEADA 133
Cdd:PRK07810 63 VYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVfTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 134 SDLQsfQDEIAVTRP-DLVWLEVPSNPFLKVADIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNG 212
Cdd:PRK07810 143 EDLS--QWEEALSVPtQAVFFETPSNPMQSLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDG 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 213 HSDLLGGVV--TTDNAGSEAWAFLteerKLAGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYP 290
Cdd:PRK07810 221 QGRVLGGAIlgDREYIDGPVQKLM----RHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYP 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 291 GVKSHPHHELAKSQMTGGfGSLMSIQVKGD----KTAALNVTGALDLFQRATSLGGTESLVEHRFTI-------EGEGS- 358
Cdd:PRK07810 297 FLPSHPQYDLAKRQMSGG-GTVVTFELDAPedaaKKRAFEVLDKLRVIDISNNLGDAKSLITHPATTthramgpEGRAAi 375
|
330 340
....*....|....*....|....*..
gi 1011638920 359 GIPENLLRLSIGIEHCDDLIADMEQAL 385
Cdd:PRK07810 376 GLGDGVVRLSVGLEDTDDLIADLDRAL 402
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
19-388 |
2.22e-49 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 172.36 E-value: 2.22e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 19 HGGGGFDAATGAVVPPIQTATTFVRDET------YELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAAVAA 92
Cdd:PRK05613 20 HAGQSVDSDTSARNLPIYQTTSYVFDSAehakqrFALEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFASGQAAETA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 93 V-ARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNI--ALVEaDASDLQSFQDEIavtRPDLVWL--EVPSNPFLKVADIK 167
Cdd:PRK05613 100 AiLNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIevTFVE-NPDDPESWQAAV---QPNTKAFfgETFANPQADVLDIP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 168 NIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGV----------------------VTTDN 225
Cdd:PRK05613 176 AVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVlidggkfdwtverdgkpvfpyfVTPDP 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 226 A---------GSEAWAFLTEERKL--AGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKS 294
Cdd:PRK05613 256 AyhglkyadlGAPAFGLKARAGLLrdTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFAGLKD 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 295 HPHHELAKSQMTGGFGSLMSIQVKGDKTAALNVTGALDLFQRATSLGGTESLVEHRFTIEGEGS--------GIPENLLR 366
Cdd:PRK05613 336 SPWYATKEKLGLKYTGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSdeaglaraGITQATVR 415
|
410 420
....*....|....*....|..
gi 1011638920 367 LSIGIEHCDDLIADMEQALTAI 388
Cdd:PRK05613 416 LSVGIEDIDDIIADLEGGFAAI 437
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
1-388 |
5.62e-45 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 159.59 E-value: 5.62e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 1 MPKTPSIAHGLHLDSLLAHGGGGFDAATGAVVPPIQTATT--FVRDETYELVNPGHIYSRDDNALFKKTEKLIAALEGGE 78
Cdd:PRK05967 1 MAKKQLKTEKAGINTRLAHDGNDPGDYHGFVNPPVVHASTvlFPDAETMATRGQKYTYGTRGTPTTDALCKAIDALEGSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 79 DSRLFASGMAAVAA-VARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNialVEADASDLQSFQDEIAVTRPD--LVWLEV 155
Cdd:PRK05967 81 GTILVPSGLAAVTVpFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLG---VEVEYYDPEIGAGIAKLMRPNtkVVHTEA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 156 P-SNPFlKVADIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTtdnAGSEAWAFL 234
Cdd:PRK05967 158 PgSNTF-EMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVS---ANEKCWPQL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 235 TEERKLAGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTGGFGsLMS 314
Cdd:PRK05967 234 LEAHGTLGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASG-IFS 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 315 IQVKGD----KTAALNVTGALDLFQRATSLGGTESLVEH-----RFTIEGEGSGipeNLLRLSIGIEHCDDLIADMEQAL 385
Cdd:PRK05967 313 FVLAAGpekgKAKAHAFLDALEIFGLGYSWGGYESLALHvklgdRTVAKAPYAG---PVIRLQIGLEDVPDLKADLERGF 389
|
...
gi 1011638920 386 TAI 388
Cdd:PRK05967 390 AAA 392
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
71-388 |
4.32e-37 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 138.32 E-value: 4.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 71 IAALEGGEDSRLFASGMAAVAAV-ARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIA------LVEADASDLqsFQDEi 143
Cdd:PRK07050 74 LAEIEGGRHALLQPSGLAAISLVyFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITvrfydpLIGAGIADL--IQPN- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 144 avTRpdLVWLEVPSNPFLKVADIKNIANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTT 223
Cdd:PRK07050 151 --TR--LIWLEAPGSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATIT 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 224 DNAgsEAWAFLTEERKLAGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKS 303
Cdd:PRK07050 227 ADA--ELHAKLKLARMRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMR 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 304 QMTGGfGSLMSIQVKGDKTAAL--NVTGALDLFQRATSLGGTESL-----VEHRFTIEGEGSGipeNLLRLSIGIEHCDD 376
Cdd:PRK07050 305 DFTGA-GGLFSVVFDERYSPAQvdAFVEALELFAIGWSWGGACSLampydVASMRTAKWPHRG---TLVRLYIGLEDEAD 380
|
330
....*....|..
gi 1011638920 377 LIADMEQALTAI 388
Cdd:PRK07050 381 LIADLEQALEAA 392
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
29-385 |
3.10e-34 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 130.62 E-value: 3.10e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 29 GAVVPPIQTATTFVRDETYEL-------VNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAA-VAAVARIVKPG 100
Cdd:PRK09028 21 GVINPPVFRASTVVFDTVAEMrhaaknrANGEMFYGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAiSNALLSFLKAG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 101 GTLLAQSGIYWGTTLFLRKMCARNNIALVEADASDLQSFQDEIavtRPD--LVWLEVPSNPFLKVADIKNIANQCKQADA 178
Cdd:PRK09028 101 DHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELI---RPNtkVLFLESPGSITMEVQDVPTLSRIAHEHDI 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 179 LLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTtdnAGSEAWAFLTEERKLAGAVLGSFETWLLLRGLR 258
Cdd:PRK09028 178 VVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTAT---ANEKHWDQLREHSYLMGQCTSPDDVYLAMRGLR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 259 TLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTGGFGsLMSIQVK-GDKTAALNVTGALDLFQRA 337
Cdd:PRK09028 255 TLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNG-LFSFVLKqGDPKAVTALVEGMQHFKMG 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1011638920 338 TSLGGTESLVEHRFTIEGEGSGIPEN----LLRLSIGIEHCDDLIADMEQAL 385
Cdd:PRK09028 334 FSWGGFESLILGVFGINKLRTATNWDfskpLIRLHIGLEDVDDLIADLEAGF 385
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
22-385 |
1.53e-33 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 129.40 E-value: 1.53e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 22 GGFDAATGAV-VPPIQTATTFVRDET------YELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAA-VAAV 93
Cdd:PRK06702 14 GGYTPKNGEPrVLPLYQSTTYKYDTSddlaalFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAiMLAV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 94 ARIVKPGGTLLAQSGIYWGT-TLF---LRKMCARNNIALVEADASDLQSFQDEiavtRPDLVWLEVPSNPFLKVADIKNI 169
Cdd:PRK06702 94 LNICSSGDHLLCSSTVYGGTfNLFgvsLRKLGIDVTFFNPNLTADEIVALAND----KTKLVYAESLGNPAMNVLNFKEF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 170 ANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGVVTtdNAGSEAW------------------ 231
Cdd:PRK06702 170 SDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVI--DGGNFDWtngkypelvepdpsyhgv 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 232 ---------AFLTEER----KLAGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHH 298
Cdd:PRK06702 248 syvqnfgaaAYIVKARvqllRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENY 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 299 ELAKSQMTGGFGSLMSIQVKGDKTAALNVTGALDLFQRATSLGGTESLVEH-------RFTIEGEG-SGIPENLLRLSIG 370
Cdd:PRK06702 328 SLAQKYLKKGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHpastthrQLSAEDQRlAGVTSDLIRLSVG 407
|
410
....*....|....*
gi 1011638920 371 IEHCDDLIADMEQAL 385
Cdd:PRK06702 408 IEDVSDIIADLEAAL 422
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
12-388 |
7.54e-33 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 126.74 E-value: 7.54e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 12 HLDSLLAHGGGGFDAATGAVVPPIQTATTFVRDE-------TYELVNPGHIYSRDDNALFKKTEKLIAALEGGEDSRLFA 84
Cdd:PRK08114 5 KLDTQLVNAGRSKKYTQGSVNSVIQRASSLVFDSveakkhaTRNRANGELFYGRRGTLTHFSLQEAMCELEGGAGCALYP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 85 SGMAAVAAV-ARIVKPGGTLLAQSGIYWGTTLFLRKMCARNNIA------LVEADASDLqsFQDEIAVtrpdlVWLEVPS 157
Cdd:PRK08114 85 CGAAAVANAiLAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTttwfdpLIGADIAKL--IQPNTKV-----VFLESPG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 158 NPFLKVADIKNI--ANQCKQADALLAVDATAATPLILKPLSLGADLVMHSATKALNGHSDLLGGvvtTDNAGSEAWAFLT 235
Cdd:PRK08114 158 SITMEVHDVPAIvaAVRSVNPDAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIG---TAVANARCWEQLR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 236 EERKLAGAVLGSFETWLLLRGLRTLALRVERMNRSAQVFAEHFEKHPKVEAVLYPGVKSHPHHELAKSQMTGGFGsLMSI 315
Cdd:PRK08114 235 ENSYLMGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSG-LFSF 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 316 QVKgDKTAALNVTGALD---LFQRATSLGGTESLV-----EHRFTIE-GEGSGIPENLLRLSIGIEHCDDLIADMEQALT 386
Cdd:PRK08114 314 VLK-KKLTDEQLANYLDnfsLFSMAYSWGGFESLIlanqpEEIAAIRpAGEVDFTGTLIRLHIGLEDVDDLIADLAAGFA 392
|
..
gi 1011638920 387 AI 388
Cdd:PRK08114 393 RI 394
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
54-371 |
1.72e-32 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 126.42 E-value: 1.72e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 54 HIYSRDDNALFKKTEKLIAALEGGEDSRLFASGMAA-VAAVARIVKPGGTLLAQSGIYWGTTLFLRKMCAR-NNIALVEA 131
Cdd:PLN02242 68 YIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAiSSVLLQLCSSGGHVVASNTLYGGTHALLAHFLPRkCNITTTFV 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 132 DASDLQSFQDEIAVTRPDLVWLEVPSNPFLKVADIKNIANQCKQADALLAVDATAAtPLILKPLSLGADLVMHSATKALN 211
Cdd:PLN02242 148 DITDLEAVKKAVVPGKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTFA-PMVLSPARLGADVVVHSISKFIS 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 212 GHSDLLGGVVttdnAGSEawAFLTEERKL-AGA--VLG-------SFEtwLLLRgLRTLALRVERMNRSAQVFAEHFEKH 281
Cdd:PLN02242 227 GGADIIAGAV----CGPA--ELVNSMMDLhHGAlmLLGptmnpkvAFE--LSER-LPHLSLRMKEHCRRAMEYAKRMKEL 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 282 PKveAVLYPGVKSHPHHELAKSQMTG--GFGSLMSIQVKGDKTAAL------NVTGaldlFQ-RATSLGGTESLVE---- 348
Cdd:PLN02242 298 GL--KVIYPGLEDHPQHALLKSMANKgyGFGGLLCLDMDTEERANRlmrylqNSTQ----FGfMAVSLGYYETLMScsgs 371
|
330 340
....*....|....*....|....*..
gi 1011638920 349 ---HRFTIEG-EGSGIPENLLRLSIGI 371
Cdd:PLN02242 372 stsSELDPEEkAAAGISPGLVRMSVGY 398
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
96-224 |
6.03e-05 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 43.14 E-value: 6.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011638920 96 IVKPGGTLLAQSGIYWGTTLF--LRKMCARNNIALVEADA--SDLQSFQDEIAVTRPDLVWLEVPSNPFLKVADIKNIAN 171
Cdd:cd01494 37 LLGPGDEVIVDANGHGSRYWVaaELAGAKPVPVPVDDAGYggLDVAILEELKAKPNVALIVITPNTTSGGVLVPLKEIRK 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1011638920 172 QCKQADALLAVDATAATPLILKPLSL----GADLVMHSATKALNGHSdllGGVVTTD 224
Cdd:cd01494 117 IAKEYGILLLVDAASAGGASPAPGVLipegGADVVTFSLHKNLGGEG---GGVVIVK 170
|
|
| |
