|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
120-453 |
6.19e-54 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 185.14 E-value: 6.19e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 120 FQLLVTGFFDNETDNTVGVRFKSSEGYVAVFMRPDIGQTFSEFRIFLALLIILLLIISISLIIASTYAIIKPIQSLKYAT 199
Cdd:COG5002 45 LLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSEL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 200 ERLMHGDFDTPIKQTRTDEIGILQYRFDTMRQSLKQVDAMRQHFVQNVSHEMKTPLTHIHHALTQLQ--ASDDKATQQTI 277
Cdd:COG5002 125 LLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLdgAADDPEERREY 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 278 INDLFTITSRLSDLTRELLILSELDnASHIQLNSTIQLDLLLQDLIRHE-QYLIERKNIIVYAELLPSSLL--GNERLLH 354
Cdd:COG5002 205 LEIILEEAERLSRLVNDLLDLSRLE-SGELKLEKEPVDLAELLEEVVEElRPLAEEKGIELELDLPEDPLLvlGDPDRLE 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 355 QAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTSN----GLGLSITQAIVQ 430
Cdd:COG5002 284 QVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSREtggtGLGLAIVKHIVE 363
|
330 340
....*....|....*....|...
gi 1011156493 431 LHHGHIEVESNNLIGTQFTVILP 453
Cdd:COG5002 364 AHGGRIWVESEPGKGTTFTITLP 386
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
225-453 |
1.40e-49 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 168.93 E-value: 1.40e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 225 RFDTMRQSLKQVDAMRQHFVQNVSHEMKTPLTHIHHALTQLQ--ASDDKATQQTIINDLFTITSRLSDLTRELLILSELD 302
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLdeEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 303 nASHIQLNSTIQLDLLLQDLIRHE-QYLIERKNIIVYAELLPSSLL--GNERLLHQAFENLLRNAIKYTNNEGAINIKLQ 379
Cdd:COG2205 81 -SGKLSLELEPVDLAELLEEAVEElRPLAEEKGIRLELDLPPELPLvyADPELLEQVLANLLDNAIKYSPPGGTITISAR 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011156493 380 HRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTS--NGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:COG2205 160 REGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEggTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
214-453 |
5.71e-48 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 167.39 E-value: 5.71e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 214 TRTDEIGILQYRFDTMRQSLKQVDAMRQHFVQNVSHEMKTPLTHIHhALTQLQASDDKATQQTIINDLFTITSRLSDLTR 293
Cdd:COG0642 84 LLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIR-GYLELLLEELDEEQREYLETILRSADRLLRLIN 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 294 ELLILSELDnASHIQLNSTIQLDLLLQDLIRHE-QYLIERKNIIVYAEL--LPSSLLGNERLLHQAFENLLRNAIKYTNN 370
Cdd:COG0642 163 DLLDLSRLE-AGKLELEPEPVDLAELLEEVVELfRPLAEEKGIELELDLpdDLPTVRGDPDRLRQVLLNLLSNAIKYTPE 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 371 EGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTSN--GLGLSITQAIVQLHHGHIEVESNNLIGTQF 448
Cdd:COG0642 242 GGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGgtGLGLAIVKRIVELHGGTIEVESEPGKGTTF 321
|
....*
gi 1011156493 449 TVILP 453
Cdd:COG0642 322 TVTLP 326
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
353-452 |
1.25e-32 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 119.24 E-value: 1.25e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTS--NGLGLSITQAIVQ 430
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGggTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 1011156493 431 LHHGHIEVESNNLIGTQFTVIL 452
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
348-455 |
1.37e-31 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 116.98 E-value: 1.37e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 348 GNERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTS---NGLGLSI 424
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKiggTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|.
gi 1011156493 425 TQAIVQLHHGHIEVESNNLIGTQFTVILPFK 455
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
215-453 |
7.68e-31 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 123.80 E-value: 7.68e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 215 RTDEIGILQYRFDTMRQSL--KQ-VdamrQHFVQNVSHEMKTPLTHIHHALTQLQASDDKATQQTIINDLFTITSRLSDL 291
Cdd:PRK11100 232 GSSELRELAQALESMRVKLegKAyV----EQYVQTLTHELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQL 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 292 TRELLILSELDNASHIQLNSTIQLDLLLQDLIRHEQYLIERKNIIVYAELLPSSLLGNERLLHQAFENLLRNAIKYTNNE 371
Cdd:PRK11100 308 IDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEG 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 372 GAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFY---KVNSNDTSNGLGLSITQAIVQLHHGHIEVESNNLIGTQF 448
Cdd:PRK11100 388 GTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLA 467
|
....*
gi 1011156493 449 TVILP 453
Cdd:PRK11100 468 TLTLP 472
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
188-453 |
4.61e-29 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 118.97 E-value: 4.61e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 188 IIKPIQSLKYATERLMHGDFDTPIKQTRTDEIGILQYRFDTMRQSLKQVDAMRQHFVQNVSHEMKTPLTHIHHALTQLQA 267
Cdd:PRK10549 188 LLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAIQD 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 268 SDDKATQQTIINDLFTITSrLSDLTRELLILSELDNA------SHIQLNSTIQLDLLLQdlirHEQYliERKNIIVYAEL 341
Cdd:PRK10549 268 GVRKFTPESVASLQAEVGT-LTKLVDDLHQLSLSDEGalayrkTPVDLVPLLEVAGGAF----RERF--ASRGLTLQLSL 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 342 LPS-SLLGNERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQnDGQPMTKEAQL-HIFDRFYKVNS--NDTS 417
Cdd:PRK10549 341 PDSaTVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFA-DSAPGVSDEQLqKLFERFYRTEGsrNRAS 419
|
250 260 270
....*....|....*....|....*....|....*...
gi 1011156493 418 --NGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:PRK10549 420 ggSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 457
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
348-456 |
3.02e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 107.84 E-value: 3.02e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 348 GNERLLHQAFENLLRNAIKYTNNEGAINIKLqHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTS-NGLGLSITQ 426
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGgTGLGLSIVR 79
|
90 100 110
....*....|....*....|....*....|
gi 1011156493 427 AIVQLHHGHIEVESNNLIGTQFTVILPFKP 456
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
199-453 |
6.37e-27 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 112.03 E-value: 6.37e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 199 TERLMHGDFDTP----IKQTRTDEIGILQYrfdTMRQSL---------KQVDAMRQHFVQNVSHEMKTPLTHIHHALTQL 265
Cdd:PRK11006 153 TQYLKTRDFSRPltlvLNNGRHLEIRVMPY---TEGQLLmvardvtqmHQLEGARRNFFANVSHELRTPLTVLQGYLEMM 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 266 QASD-DKATQQTIINDLFTITSRLSDLTRELLILSELDNASHIQLNSTIQLDLLLQDLIRHEQYLIERKNIIVY---AEL 341
Cdd:PRK11006 230 QDQPlEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLEREAQTLSQGKHTITFevdNSL 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 342 lpsSLLGNERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVN---SNDT-S 417
Cdd:PRK11006 310 ---KVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDkarSRQTgG 386
|
250 260 270
....*....|....*....|....*....|....*.
gi 1011156493 418 NGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:PRK11006 387 SGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
247-453 |
1.52e-25 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 108.13 E-value: 1.52e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 247 VSHEMKTPLT-------HIHHALTQLQASDDKATQQ---TIIN---DLFTITSRLSDLTR-ELLILSELDNASHIQlnst 312
Cdd:COG5000 208 IAHEIKNPLTpiqlsaeRLRRKLADKLEEDREDLERaldTIIRqvdRLKRIVDEFLDFARlPEPQLEPVDLNELLR---- 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 313 iqldlllqDLIRHEQYLIERKNIIVYAELLPSS--LLGNERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQ 390
Cdd:COG5000 284 --------EVLALYEPALKEKDIRLELDLDPDLpeVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVS 355
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011156493 391 NDGQPMTKEAQLHIFDRFYKVNSNDTsnGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:COG5000 356 DNGPGIPEEVLERIFEPFFTTKPKGT--GLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
213-453 |
1.73e-25 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 106.81 E-value: 1.73e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 213 QTRTDEIGILQYRFDTMRQSLKQVDAMRQHFVQN------------VSHEMKTPLT----HIHHALTQLQASDDKATQQT 276
Cdd:COG4191 103 AEENAELEELERDITELERAEEELRELQEQLVQSeklaalgelaagIAHEINNPLAailgNAELLRRRLEDEPDPEELRE 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 277 IINDLFTITSRLSDLTRELLILSELDNASH--IQLNSTIQLDLLLQdlirheQYLIERKNIIV---YAELLPSsLLGNER 351
Cdd:COG4191 183 ALERILEGAERAAEIVRSLRAFSRRDEEERepVDLNELIDEALELL------RPRLKARGIEVeldLPPDLPP-VLGDPG 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 352 LLHQAFENLLRNAIK--YTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFY--KVNSNDTsnGLGLSITQA 427
Cdd:COG4191 256 QLEQVLLNLLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttKPVGKGT--GLGLSISYG 333
|
250 260
....*....|....*....|....*.
gi 1011156493 428 IVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:COG4191 334 IVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
190-440 |
6.65e-25 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 106.70 E-value: 6.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 190 KPIQSLKYATERLMHGDFDTPIKQTRT-DEIGILQYRFDTMRQSLKQVDAMRQHFVQNVSHEMKTPLTHIhhaLTQLQAS 268
Cdd:TIGR01386 190 EPLRRLSAVAARISPESLDQRLDPSRApAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNL---LGQTQVA 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 269 -----DDKATQQTIINDLFTItSRLSDLTRELLILSELDNA-SHIQLNSTIQLDLLLQDLIRHEQYLIER-KNIIVYAEL 341
Cdd:TIGR01386 267 lsqprTGEEYREVLESNLEEL-ERLSRMVSDMLFLARADNGqLALERVRLDLAAELAKVAEYFEPLAEERgVRIRVEGEG 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 342 lpsSLLGNERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVN---SNDTSN 418
Cdd:TIGR01386 346 ---LVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDparSNSGEG 422
|
250 260
....*....|....*....|...
gi 1011156493 419 -GLGLSITQAIVQLHHGHIEVES 440
Cdd:TIGR01386 423 tGLGLAIVRSIMEAHGGRASAES 445
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
229-456 |
7.42e-25 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 104.93 E-value: 7.42e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 229 MRQSLKQVDAMR--QHFVQNVSHEMKTPLTHIHHAL----TQLQASDDKATQQTIINDlftiTSRLSDLTRELLILSELD 302
Cdd:COG3852 122 LERELRRAEKLAavGELAAGLAHEIRNPLTGIRGAAqlleRELPDDELREYTQLIIEE----ADRLNNLVDRLLSFSRPR 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 303 NASHIQLNStiqldlllqdlirHEqyLIER----------KNIIVYAELLPS--SLLGNERLLHQAFENLLRNAIKYTNN 370
Cdd:COG3852 198 PPEREPVNL-------------HE--VLERvlellraeapKNIRIVRDYDPSlpEVLGDPDQLIQVLLNLVRNAAEAMPE 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 371 EGAINIKL----------QHRNNHVHFTIQNDGQPMTKEAQLHIFDRFykVNSNDTSNGLGLSITQAIVQLHHGHIEVES 440
Cdd:COG3852 263 GGTITIRTrverqvtlggLRPRLYVRIEVIDNGPGIPEEILDRIFEPF--FTTKEKGTGLGLAIVQKIVEQHGGTIEVES 340
|
250
....*....|....*.
gi 1011156493 441 NNLIGTQFTVILPFKP 456
Cdd:COG3852 341 EPGKGTTFRIYLPLEQ 356
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
186-453 |
1.04e-24 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 106.17 E-value: 1.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 186 YAIIKPIQSLKYATERLMHGDFdtpiKQTRTDEIGILQYR-----FDTMRQSLKQVDAMRQHFVQNVSHEMKTPLTHIHH 260
Cdd:PRK09470 188 WSLAKPARKLKNAADEVAQGNL----RQHPELETGPQEFRqagasFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 261 AL----------TQLQASDDKATQ-QTIINDLFTItSRL---SDLTRELLILSE-----LDNAshiqlnstiqldlllqd 321
Cdd:PRK09470 264 ATallrrrqgesKELERIETEAQRlDSMINDLLVL-SRNqqkNHLERETFKANSlwsevLEDA----------------- 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 322 lirheQYLIERKNIIVYAELLPS--SLLGNERLLHQAFENLLRNAIKYTNNEGAINIKLQhrNNHVHFTIQNDGQPMTKE 399
Cdd:PRK09470 326 -----KFEAEQMGKSLTVSAPPGpwPINGNPNALASALENIVRNALRYSHTKIEVAFSVD--KDGLTITVDDDGPGVPEE 398
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 400 AQLHIFDRFYKV------NSNDTsnGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:PRK09470 399 EREQIFRPFYRVdeardrESGGT--GLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
241-456 |
2.28e-24 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 105.64 E-value: 2.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 241 QHFVQNVSHEMKTPLTHIHHALTQLQAS-----DDKATQ--QTIINdlftITSRLSDLTRELLILSELDNA----SHIQL 309
Cdd:COG4251 283 EQFAYVASHDLREPLRKISGFSQLLEEDygdklDEEGREylERIRD----AAERMQALIDDLLAYSRVGRQelefEPVDL 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 310 NSTIQLDLLLQdlirheQYLIERKNIIVYAELLPSsLLGNERLLHQAFENLLRNAIKYT--NNEGAINIKLQHRNNHVHF 387
Cdd:COG4251 359 NELLEEVLEDL------EPRIEERGAEIEVGPLPT-VRGDPTLLRQVFQNLISNAIKYSrpGEPPRIEIGAEREGGEWVF 431
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011156493 388 TIQNDGQPMTKEAQLHIFDRFYKVNSNDT--SNGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILPFKP 456
Cdd:COG4251 432 SVRDNGIGIDPEYAEKIFEIFQRLHSRDEyeGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAP 502
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
3.21e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 93.54 E-value: 3.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYTNNEGAINIKLQHrnNHVHFTIQNDGqPMTKEAQL-HIFDRFYKVNSNDTSN----GLGLSITQA 427
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDG--DQWTITITDDG-PGVPEDQLeQIFLPFYRVDSARDREsggtGLGLAIAER 77
|
90 100
....*....|....*....|....*.
gi 1011156493 428 IVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:cd16949 78 AIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
190-453 |
1.21e-21 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 97.15 E-value: 1.21e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 190 KPIQSLKYATERLMHGDFDTPIKQTRTD-EIGILQYRFDTMRQSLKQVDAMRQHFVQNVSHEMKTPLTHIhhaLTQLQAS 268
Cdd:PRK09835 211 APIRSVSRQIQNITSKDLDVRLDPQTVPiELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNL---ITQTEIA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 269 DDKATQQTIINDLftITSRLSDLTR------ELLILSELDNASHIQLNSTIQLDLLLQDLIRHEQYLIERKNIIVYAELL 342
Cdd:PRK09835 288 LSQSRSQKELEDV--LYSNLEELTRmakmvsDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGD 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 343 PSSLLGNERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVN----SNDTSN 418
Cdd:PRK09835 366 PCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDpsrqRKGEGS 445
|
250 260 270
....*....|....*....|....*....|....*
gi 1011156493 419 GLGLSITQAIVQLHHGHIEVESnNLIGTQFTVILP 453
Cdd:PRK09835 446 GIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-453 |
7.91e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 87.09 E-value: 7.91e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 352 LLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTSNGLGLSITQAIVQL 431
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQK 82
|
90 100
....*....|....*....|..
gi 1011156493 432 HHGHIEVESNNLIGTQFTVILP 453
Cdd:cd16943 83 HGGTIRVASVPGGGTRFTIILP 104
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
243-456 |
2.03e-19 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 90.80 E-value: 2.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 243 FVQNVSHEMKTPLTHIHHALTQLQASDDKATQQTIINDLFTITSRLSDLTRELLILSElDNASHIQLNSTIQLDLLLQDL 322
Cdd:PRK11360 393 LVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSR-PRESQWQPVSLNALVEEVLQL 471
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 323 IRHEQYLIERKNIIVYAELLPSSLLGNErLLHQAFENLLRNAIKYTNNEGAINIKL-QHRNNHVHFTIQNDGQPMTKEAQ 401
Cdd:PRK11360 472 FQTAGVQARVDFETELDNELPPIWADPE-LLKQVLLNILINAVQAISARGKIRIRTwQYSDGQVAVSIEDNGCGIDPELL 550
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1011156493 402 LHIFDRFYKVNSNDTsnGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILPFKP 456
Cdd:PRK11360 551 KKIFDPFFTTKAKGT--GLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINP 603
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
359-454 |
4.33e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 82.16 E-value: 4.33e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 359 NLLRNAIKYTNnEGAINIKLQ-----HRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTSN----GLGLSITQAIV 429
Cdd:cd16922 7 NLLGNAIKFTE-EGEVTLRVSleeeeEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKyggtGLGLAISKKLV 85
|
90 100
....*....|....*....|....*
gi 1011156493 430 QLHHGHIEVESNNLIGTQFTVILPF 454
Cdd:cd16922 86 ELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
190-453 |
1.60e-18 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 87.35 E-value: 1.60e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 190 KPIQSLKYATERLMHGDFDTPIKQTRTDEIGILQYRFDTMRQSLKQVDAMRQHFVQNVSHEMKTPLTHIHHALTQLQASD 269
Cdd:PRK10604 162 QDMLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLS 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 270 DkATQQTIINDLftitSRLSDLTRELLILSELD------NASHIQLNSTIQLDLLLQDLIRHEQYLIerkniivyAELLP 343
Cdd:PRK10604 242 A-AESQALNRDI----GQLEALIEELLTYARLDrpqnelHLSEPDLPAWLSTHLADIQAVTPEKTVR--------LDTPH 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 344 SSLLG--NERLLHQAFENLLRNAIKYtnNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVN-SNDTSN-- 418
Cdd:PRK10604 309 QGDYGalDMRLMERVLDNLLNNALRY--AHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDpSRDRATgg 386
|
250 260 270
....*....|....*....|....*....|....*.
gi 1011156493 419 -GLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:PRK10604 387 cGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
247-453 |
5.77e-17 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 83.10 E-value: 5.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 247 VSHEMKTPLTHIHhALTQLQASDDKATQQTIINdlfTITS---RLSDLTRELLILS-------ELDNASHIqLNSTIQld 316
Cdd:COG5809 277 IAHEIRNPLTSLK-GFIQLLKDTIDEEQKTYLD---IMLSeldRIESIISEFLVLAkpqaikyEPKDLNTL-IEEVIP-- 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 317 lllqdlirheqyLIE----RKNIIVYAEL---LPSsLLGNERLLHQAFENLLRNAIKYTNNEGAINIKLQ-HRNNHVHFT 388
Cdd:COG5809 350 ------------LLQpqalLKNVQIELELeddIPD-ILGDENQLKQVFINLLKNAIEAMPEGGNITIETKaEDDDKVVIS 416
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011156493 389 IQNDGQPMTKEAQLHIFDRFYKVNSNDTsnGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:COG5809 417 VTDEGCGIPEERLKKLGEPFYTTKEKGT--GLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-450 |
5.84e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 76.29 E-value: 5.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 348 GNERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNnHVHFTIQNDGQPMTKEAQLHIFDRFYKVN-SNDTSNGLGLSITQ 426
Cdd:cd16940 9 GDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADD-GAVIRVEDNGPGIDEEELEALFERFYRSDgQNYGGSGLGLSIVK 87
|
90 100
....*....|....*....|....
gi 1011156493 427 AIVQLHHGHIEVESNNLIGTQFTV 450
Cdd:cd16940 88 RIVELHGGQIFLGNAQGGGLEAWV 111
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
8.75e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 75.50 E-value: 8.75e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNdgqPMTKEAQLH---IFDRFYKV-NSNDTSN-GLGLSITQA 427
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKN---PSSHPLDFKlekLFERFYRGdNSRNTEGaGLGLSIAKA 77
|
90 100
....*....|....*....|....*.
gi 1011156493 428 IVQLHHGHIEVESNNLIGTqFTVILP 453
Cdd:cd16923 78 IIELHGGSASAEYDDNHDL-FKVRLP 102
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
217-453 |
1.50e-16 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 81.15 E-value: 1.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 217 DEIGILQYRFDTMRQSLK---QVDAMrqhfvqnVSHEMKTPLTHIHHAL-TQLQASDDKATQQTIindlfTITSRLSDLT 292
Cdd:PRK09303 132 DELFVLRQENETLLEQLKfkdRVLAM-------LAHDLRTPLTAASLALeTLELGQIDEDTELKP-----ALIEQLQDQA 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 293 R------ELLI----------LSELD-NASHIQLNSTIQLDLllqdlirhEQY--LIERKNIIVYAEL---LPSsLLGNE 350
Cdd:PRK09303 200 RrqleeiERLItdllevgrtrWEALRfNPQKLDLGSLCQEVI--------LELekRWLAKSLEIQTDIpsdLPS-VYADQ 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 351 RLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNH-VHFTIQNDGQPMTKEAQLHIF-DRFYKVNSNDTSN-GLGLSITQA 427
Cdd:PRK09303 271 ERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQkVQVSICDTGPGIPEEEQERIFeDRVRLPRDEGTEGyGIGLSVCRR 350
|
250 260
....*....|....*....|....*.
gi 1011156493 428 IVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:PRK09303 351 IVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-453 |
1.84e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 74.81 E-value: 1.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 349 NERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDT----SNGLGLSI 424
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrasgGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 1011156493 425 TQAIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
198-456 |
2.67e-16 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 81.62 E-value: 2.67e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 198 ATERLmhgdfdtpiKQTRTDEigilQYRFDTMRQSLkqvdamRQHFVQNVSHEMKTPLTHIH---HALTQLQASDD---- 270
Cdd:PRK10490 641 ALERL---------TLTASEE----QARLASEREQL------RNALLAALSHDLRTPLTVLFgqaEILTLDLASEGspha 701
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 271 -KATQ--QTIIN---------DLFTITSRLSDLTRELLILSELDNASHIQLNstiqldlllqdlirheqYLIERKNIIVY 338
Cdd:PRK10490 702 rQASEirQQVLNttrlvnnllDMARIQSGGFNLRKEWLTLEEVVGSALQMLE-----------------PGLSGHPINLS 764
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 339 aelLPSSLL---GNERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVN--S 413
Cdd:PRK10490 765 ---LPEPLTlihVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNkeS 841
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1011156493 414 NDTSNGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILPFKP 456
Cdd:PRK10490 842 AIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLET 884
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
1.38e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 72.62 E-value: 1.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTSN----GLGLSITQAI 428
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNtggtGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 1011156493 429 VQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
207-454 |
4.28e-15 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 77.76 E-value: 4.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 207 FDTPIKQTRTDEIG-----------ILQYRFDTM--------------RQSLKQVDAMRQHFVQNVSHEMKTPLTHIHHA 261
Cdd:PRK15347 340 LEPRLPENRLDELGsiakaynqlldTLNEQYDTLenkvaertqalaeaKQRAEQANKRKSEHLTTISHEIRTPLNGVLGA 419
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 262 LTQLQASDDKATQQTII-------NDLFTITSRLSDLTR-----------ELLILSELDNASH-IQLNStiqldlllqdl 322
Cdd:PRK15347 420 LELLQNTPLTAEQMDLAdtarqctLSLLAIINNLLDFSRiesgqmtlsleETALLPLLDQAMLtIQGPA----------- 488
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 323 irHEQYLIERknIIVYAELlPSSLLGNERLLHQAFENLLRNAIKYTNnEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQL 402
Cdd:PRK15347 489 --QSKSLTLR--TFVGAHV-PLYLHLDSLRLRQILVNLLGNAVKFTE-TGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQ 562
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1011156493 403 HIFDRFYKVNSNDTSNGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILPF 454
Cdd:PRK15347 563 QIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPL 614
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-438 |
6.26e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 70.57 E-value: 6.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 352 LLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKV---NSNDTSNGLGLSITQAI 428
Cdd:cd16945 4 LLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLprpHSGQKSTGLGLAFVQEV 83
|
90
....*....|
gi 1011156493 429 VQLHHGHIEV 438
Cdd:cd16945 84 AQLHGGRITL 93
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
243-433 |
9.09e-15 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 75.84 E-value: 9.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 243 FVQNVSHEMKTPLTHI-----------------HHALTQLQASDDKATqqtiindlftitsRLSDltrELLILSELDNAS 305
Cdd:PRK10337 240 FTSDAAHELRSPLAALkvqtevaqlsdddpqarKKALLQLHAGIDRAT-------------RLVD---QLLTLSRLDSLD 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 306 HIQ----------LNSTIQLDLLLQDLIRHEQYL-IERKNIIVYAELLPSSLLgnerllhqaFENLLRNAIKYTNNEGAI 374
Cdd:PRK10337 304 NLQdvaeipledlLQSAVMDIYHTAQQAGIDVRLtLNAHPVIRTGQPLLLSLL---------VRNLLDNAIRYSPQGSVV 374
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 375 NIKLQHRnnhvHFTIQNDGQPMTKEAQLHIFDRFYKVNSND-TSNGLGLSITQAIVQLHH 433
Cdd:PRK10337 375 DVTLNAR----NFTVRDNGPGVTPEALARIGERFYRPPGQEaTGSGLGLSIVRRIAKLHG 430
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
335-456 |
2.64e-14 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 74.11 E-value: 2.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 335 IIVYAELLPSSLLGNERLLHQAFENLLRNAI----KYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFY- 409
Cdd:COG3290 264 LTIDIDSDLPDLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFs 343
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1011156493 410 -KVNSNdtsNGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILPFKP 456
Cdd:COG3290 344 tKLGEG---RGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEG 388
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
187-455 |
3.25e-14 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 74.94 E-value: 3.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 187 AIIKPIQSLKYATERLMHGDFDTPIKQT----RTDEIGILqyrFDTMRQSLKQVDAMRQH-------------------- 242
Cdd:PRK11466 355 SVTRPLAEQTQALQRLLDGDIDSPFPETagvrELDTIGRL---MDAFRSNVHALNRHREQlaaqvkartaelqelviehr 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 243 ---------------FVQNVSHEMKTPLthiHHALTQLQASDDKATQQTIINDLFTITSRLSDLtreLLILSELDNASHI 307
Cdd:PRK11466 432 qaraeaekasqaksaFLAAMSHEIRTPL---YGILGTAQLLADNPALNAQRDDLRAITDSGESL---LTILNDILDYSAI 505
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 308 QLNSTIQLDLLLQDLIRH---------EQYLIER--KNIIVYAELLPSSLLGNERLLHQAFENLLRNAIKYTnNEGAINI 376
Cdd:PRK11466 506 EAGGKNVSVSDEPFEPRPllestlqlmSGRVKGRpiRLATDIADDLPTALMGDPRRIRQVITNLLSNALRFT-DEGSIVL 584
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1011156493 377 KLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTSNGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILPFK 455
Cdd:PRK11466 585 RSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLR 663
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
247-453 |
1.98e-13 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 72.07 E-value: 1.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 247 VSHEMKTPLTHIHHALTQLQASddKATQQTIINDLFTITSRLSDLTRELLILSElDNASHIQLNSTIQLDLLLQDLIRHE 326
Cdd:COG5805 294 IAHEIRNPLTSIKGFLQLLQPG--IEDKEEYFDIMLSELDRIESIISEFLALAK-PQAVNKEKENINELIQDVVTLLETE 370
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 327 QYLierKNIIVYAELLPSS--LLGNERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHI 404
Cdd:COG5805 371 AIL---HNIQIRLELLDEDpfIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKL 447
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1011156493 405 FDRFYKVNSNDTsnGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:COG5805 448 GEPFFTTKEKGT--GLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-450 |
3.29e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 65.56 E-value: 3.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 349 NERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTSN---GLGLSIT 425
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGghyGMGLYIA 80
|
90 100
....*....|....*....|....*
gi 1011156493 426 QAIVQLHHGHIEVESNNLIGTQFTV 450
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-452 |
4.58e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 65.61 E-value: 4.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 347 LGNERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKV----NSNDTSNGLGL 422
Cdd:cd16947 15 NANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLedsrNSAKQGNGLGL 94
|
90 100 110
....*....|....*....|....*....|
gi 1011156493 423 SITQAIVQLHHGHIEVESNNLIGTQFTVIL 452
Cdd:cd16947 95 TITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
343-453 |
7.08e-13 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 70.77 E-value: 7.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 343 PSSLLGNERLLHQAFENLLRNAIKYTNNeGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTSN---- 418
Cdd:PRK10841 553 PVALNGDPMRLQQVISNLLSNAIKFTDT-GCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNfqgt 631
|
90 100 110
....*....|....*....|....*....|....*
gi 1011156493 419 GLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:PRK10841 632 GLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
190-438 |
1.33e-12 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 69.17 E-value: 1.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 190 KPIQSLKYATERLMHGDFDTPIKQTRTDEIGILQYRFDTMRQSLKQVDAMRQHFVQNVSHEMKTPLTHIHHAlTQLQASD 269
Cdd:PRK09467 179 RPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIRLA-TEMMSEE 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 270 DKATQQTIINDL---------F-----------TITSRLSDLTRELlILSELDNASHIQLNSTiqldlllqdlirheqyl 329
Cdd:PRK09467 258 DGYLAESINKDIeecnaiieqFidylrtgqempMEMADLNALLGEV-IAAESGYEREIETALQ----------------- 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 330 ierkniivyaeLLPSSLLGNERLLHQAFENLLRNAIKYTNneGAINIKLQHRNNHVHFTIQNDGqPMTKEAQL-HIFDRF 408
Cdd:PRK09467 320 -----------PGPIEVPMNPIAIKRALANLVVNAARYGN--GWIKVSSGTEGKRAWFQVEDDG-PGIPPEQLkHLFQPF 385
|
250 260 270
....*....|....*....|....*....|..
gi 1011156493 409 YKVNSNDTS--NGLGLSITQAIVQLHHGHIEV 438
Cdd:PRK09467 386 TRGDSARGSsgTGLGLAIVKRIVDQHNGKVEL 417
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
225-455 |
3.81e-12 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 67.89 E-value: 3.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 225 RFDTMRQSLKqvDAMRQ--------HFVQNVSHEMKTPLTHIHHALTQLQA-----SDDKATQQTIINDlftiTSRLSDL 291
Cdd:PRK10364 216 RYLRSRQLLQ--DEMKRkeklvalgHLAAGVAHEIRNPLSSIKGLAKYFAErapagGEAHQLAQVMAKE----ADRLNRV 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 292 TRELLilsELDNASHIQLNSTIQLDLLlqdliRHEQYLIER----KNIIVY---AELLPSSLLGNERLLhQAFENLLRNA 364
Cdd:PRK10364 290 VSELL---ELVKPTHLALQAVDLNDLI-----NHSLQLVSQdansREIQLRftaNDTLPEIQADPDRLT-QVLLNLYLNA 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 365 IKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTsnGLGLSITQAIVQLHHGHIEVESNNLI 444
Cdd:PRK10364 361 IQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGT--GLGLAVVHNIVEQHGGTIQVASQEGK 438
|
250
....*....|.
gi 1011156493 445 GTQFTVILPFK 455
Cdd:PRK10364 439 GATFTLWLPVN 449
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
335-456 |
4.98e-12 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 67.63 E-value: 4.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 335 IIVYAELLPSSllGNERLLHQ---AFENLLRNAIKYTNN--EGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFY 409
Cdd:PRK11086 415 IISEDSQLPDS--GDEDQVHElitILGNLIENALEAVGGeeGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY 492
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1011156493 410 KVNSNDtsNGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILPFKP 456
Cdd:PRK11086 493 STKGSN--RGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDG 537
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
1.31e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 60.91 E-value: 1.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYTNNEgaINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVN-SNDTSN---GLGLSITQAI 428
Cdd:cd16939 1 MARALDNLLRNALRYAHRT--VRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDpSRDRATggfGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 1011156493 429 VQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWP 103
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
222-453 |
2.75e-11 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 65.91 E-value: 2.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 222 LQYRFDTMRQSLKQVDAMRQHFVQNVSHEMKTPLTHIHHALTQLQASDDKATQQT-IINDLFTITSRLSDLTRELLILSE 300
Cdd:PRK09959 694 LIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVeAISLAYATGQSLLGLIGEILDVDK 773
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 301 LDNASHiQLNSTIQLDLLLQDLIRHEQYLIERKNIIVYA--ELLPSSLLG--NERLLHQAFENLLRNAIKYTNnEGAINI 376
Cdd:PRK09959 774 IESGNY-QLQPQWVDIPTLVQNTCHSFGAIAASKSIALScsSTFPDHYLVkiDPQAFKQVLSNLLSNALKFTT-EGAVKI 851
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 377 --KLQH-RNNH--VHFTIQNDGQPMTKEAQLHIFDRFYKVNS--NDTSNGLGLSITQAIVQLHHGHIEVESNNLIGTQFT 449
Cdd:PRK09959 852 ttSLGHiDDNHavIKMTIMDSGSGLSQEEQQQLFKRYSQTSAgrQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFT 931
|
....
gi 1011156493 450 VILP 453
Cdd:PRK09959 932 ITIP 935
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
3.47e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 59.65 E-value: 3.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYTNNEGAINIKLQHRN--NHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTS--NGLGLSITQAI 428
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDvgEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYegTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 1011156493 429 VQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-453 |
7.14e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 58.84 E-value: 7.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 356 AFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFY--KVNSNDT-SNGLGLSITQAIV-QL 431
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFtgENGRNFQeSTGMGLYLVKKLCdKL 88
|
90 100
....*....|....*....|..
gi 1011156493 432 HHgHIEVESNNLIGTQFTVILP 453
Cdd:cd16948 89 GH-KIDVESEVGEGTTFTITFP 109
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
359-453 |
1.06e-10 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 58.66 E-value: 1.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 359 NLLRNAIKYTNNEGAINIKLQ-HRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDT----SNGLGLSITQAIVQLHH 433
Cdd:cd16925 11 NLLSNAFKFTPDGGRIRCILEkFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTrahgGTGLGLSIVKEFVELHG 90
|
90 100
....*....|....*....|
gi 1011156493 434 GHIEVESNNLIGTQFTVILP 453
Cdd:cd16925 91 GTVTVSDAPGGGALFQVELP 110
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
188-453 |
2.45e-10 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 61.91 E-value: 2.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 188 IIKPIQSLKYATERlMHGDFDTPIKQTR-TDEIGI-------LQYRFDTmrqSLKQvdaMRQhFVQNVSHEMKTPLTHIH 259
Cdd:PRK10755 85 ITRPLAELQKELEA-RTADNLTPIAIHSsTLEIEAvtsalnqLVSRLTS---TLDQ---ERL-FTADVAHELRTPLAGIR 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 260 HALTQLQasddkatQQTIInDLFTITSRLSDLTR---ELLILSELDNAshiqLNSTiqldlllqdlirHEQYLIERKNII 336
Cdd:PRK10755 157 LHLELLE-------KQHHI-DVAPLIARLDQMMHtveQLLQLARAGQS----FSSG------------HYQTVKLLEDVI 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 337 V--YAEL------------LPSS-----LLGNERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGqPMT 397
Cdd:PRK10755 213 LpsQDELsemleqrqqtllLPESaaditVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEG-PGI 291
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1011156493 398 KEAQLH-IFDRFYKVNSNDTSNGLGLSITQAIVQLHHGHIEVES-NNLIGTQFTVILP 453
Cdd:PRK10755 292 DESKCGeLSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRAWVWLP 349
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
185-455 |
2.73e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 61.96 E-value: 2.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 185 TYAIIKPIQSLKYATERLMHGDFdTPIKQTRTDEIGILQYRFDTM------------RQSLKQVDA--------MRQHFV 244
Cdd:COG2972 178 SRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMverikelieevyELELEKKEAelkalqaqINPHFL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 245 QNVshemktpLTHIHHaltQLQASDDKATQQTIIN--DLFTITsrLSDLTRELLILSELDNAshiqlnstiqldlllqdl 322
Cdd:COG2972 257 FNT-------LNSIRW---LAELEDPEEAEEMLEAlsKLLRYS--LSKGDELVTLEEELELI------------------ 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 323 irhEQYL-IER---KNIIVYAELLPSSLLGNE--RLLHQAF-ENLLRNAIKYTNNEGAINIKLQHRNNHVHFTIQNDGQP 395
Cdd:COG2972 307 ---KSYLeIQKlrfGDRLEVEIEIDEELLDLLipKLILQPLvENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVG 383
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011156493 396 MTKEAQLHIFDRFykvNSNDTSNGLGLSITQAIVQLHHG---HIEVESNNLIGTQFTVILPFK 455
Cdd:COG2972 384 MPEEKLEKLLEEL---SSKGEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIRIPLE 443
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
3.39e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 57.20 E-value: 3.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYT-NNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFY----KVNSNDTSNGLGLSITQA 427
Cdd:cd16953 1 LGQVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYterpANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 1011156493 428 IVQLHHGHIEVESNN----LIGTQFTVILP 453
Cdd:cd16953 81 IIEAHGGISVAENHNqpgqVIGARFTVQLP 110
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-453 |
9.99e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 55.76 E-value: 9.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 345 SLLGNerLLHQAFENLLRNAIKytnnEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNdTSNGLGLSI 424
Cdd:cd16915 3 TIVGN--LIDNALDALAATGAP----NKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQ-GERGIGLAL 75
|
90 100
....*....|....*....|....*....
gi 1011156493 425 TQAIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:cd16915 76 VRQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
189-233 |
1.29e-09 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 53.60 E-value: 1.29e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1011156493 189 IKPIQSLKYATERLMHGDFDTPIKQTRTDEIGILQYRFDTMRQSL 233
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
353-453 |
2.90e-09 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 59.18 E-value: 2.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYTNnEGAINIKLQ-HRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKV-NSND----TSNGLGLSITQ 426
Cdd:PRK11091 399 LRQILWNLISNAVKFTQ-QGGVTVRVRyEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGgkpaTGTGIGLAVSK 477
|
90 100
....*....|....*....|....*..
gi 1011156493 427 AIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:PRK11091 478 RLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
188-385 |
9.49e-09 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 57.82 E-value: 9.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 188 IIKPIQSLKYATERLMHGDFDTPIKQTRTDEIGILQYRFDTMRQSLKQVDAMRQHFVQnVSHEMKTPLTHIHHALTQLQA 267
Cdd:COG2770 236 ITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEE-LAEAELARLLEALLELLLALL 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 268 SDDKATQQTIINDLFTITSRLSDLTRELLILSELDNASHIQLNSTIQLDLLLQDLIRHEQYLIERKNIIVYAELLPSSLL 347
Cdd:COG2770 315 LLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLAL 394
|
170 180 190
....*....|....*....|....*....|....*...
gi 1011156493 348 GNERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHV 385
Cdd:COG2770 395 LAALAAALLLLELALEELVLALLALALLALAAAAAAAE 432
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
189-433 |
1.44e-08 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 56.39 E-value: 1.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 189 IKPIQSLKYATERLMHGDFDTPIKQTRTDEIGILQYRFDTMRQSLKQVDAMRQHFVQNVSHEMKTPLTHIHHALTQLQas 268
Cdd:NF038389 155 LKPLKKLKKQIKKFANGDFDFIKSESNGDEIGEVANEFDKAVKKIKALNESRQLFLRNIMHELKTPITKGRIVAEMLE-- 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 269 DDKATQQ---------TIINDLFTI---TSRLSDLTRELLILSE-LDNASHIqlnstiqldlllqdlirheqYLIERKNI 335
Cdd:NF038389 233 DEKQKERlisiferleSLINEFAKIeqlTSKNYKLNKKEYRLSDiIDEAIDM--------------------LMIDDSSV 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 336 IVYAELLPSSLLGNERLLHQAFENLLRNAIKYTNNeGAINIKLqhRNNHVHFtiQNDGQPMTKEAQlHIFDRFYK-VNSN 414
Cdd:NF038389 293 IIKVSLEDFKLNVDFELFSLAIKNLIDNAIKYSPD-KKVTIEI--KGDKIEF--KNKGEPLEEPLE-YYFEPFFKgNEKS 366
|
250
....*....|....*....
gi 1011156493 415 DTSNGLGLSITQAIVQLHH 433
Cdd:NF038389 367 KSGFGLGLYIVKNILKAHG 385
|
|
| HAMP |
pfam00672 |
HAMP domain; |
187-235 |
2.02e-08 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 50.32 E-value: 2.02e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1011156493 187 AIIKPIQSLKYATERLMHGDFDTPIKQTRTDEIGILQYRFDTMRQSLKQ 235
Cdd:pfam00672 5 RILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
188-235 |
2.26e-08 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 50.32 E-value: 2.26e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1011156493 188 IIKPIQSLKYATERLMHGDFDTPIKQTRTDEIGILQYRFDTMRQSLKQ 235
Cdd:smart00304 3 LLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEE 50
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
360-456 |
9.83e-08 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 54.14 E-value: 9.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 360 LLRNAIKY---TNNEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLhifdrfykvnsnDTSNGLGLSITQAIVQLHHGHI 436
Cdd:COG3920 407 LVTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDP------------PARKGLGLRLIRALVRQLGGTL 474
|
90 100
....*....|....*....|
gi 1011156493 437 EVESNNliGTQFTVILPFKP 456
Cdd:COG3920 475 ELDRPE--GTRVRITFPLAE 492
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-452 |
1.74e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 49.38 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYTNN--EGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTSNGLGLSITQAIVQ 430
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKveNPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVE 80
|
90 100
....*....|....*....|..
gi 1011156493 431 LHHGHIEVESNNLIGTQFTVIL 452
Cdd:cd16976 81 EHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
1.81e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 49.32 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYTNNEGAINIKLQHRN-----NHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTsnGLGLSITQA 427
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCERRELTIRTspaddRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGL--GMGLSICRS 78
|
90 100
....*....|....*....|....*.
gi 1011156493 428 IVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:cd16920 79 IIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
237-299 |
2.40e-07 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 47.59 E-value: 2.40e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011156493 237 DAMRQHFVQNVSHEMKTPLTHIHHALTQLQAS-DDKATQQTIINDLFTITSRLSDLTRELLILS 299
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEElLDDEEQREYLERIREEAERLLRLINDLLDLS 64
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
239-303 |
2.58e-07 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 47.59 E-value: 2.58e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011156493 239 MRQHFVQNVSHEMKTPLTHIHHALTQLQASDDKATQQTIINDLFTITSRLSDLTRELLILSELDN 303
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
343-453 |
3.53e-07 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 52.76 E-value: 3.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 343 PSSLLGNERLLHQAFENLLRNAIKYTNNEGAINIK-----------LQHRN----NHVHFTIQNDGQPMTkEAQL-HIFD 406
Cdd:PRK13837 551 PAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISlsraklrapkvLSHGVlppgRYVLLRVSDTGAGID-EAVLpHIFE 629
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1011156493 407 RFYKVNSNDTsnGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:PRK13837 630 PFFTTRAGGT--GLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
3.89e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 48.55 E-value: 3.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYTNNEGAiNIKLQHRNNH------------VHFTIQNDGQPMTKEAQLHIFDRFykVNSNDTSNGL 420
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGG-EIILRTRTQRqvtlghprhrlaLRVSVIDNGPGIPPDLQDTIFYPM--VSGRENGTGL 77
|
90 100 110
....*....|....*....|....*....|....
gi 1011156493 421 GLSITQAIVQLHHGHIEVESNNliG-TQFTVILP 453
Cdd:cd16918 78 GLAIAQNIVSQHGGVIECDSQP--GhTVFSVSLP 109
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
239-303 |
4.22e-07 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 46.79 E-value: 4.22e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011156493 239 MRQHFVQNVSHEMKTPLTHIHHALTQLQASDDKATQQTIINDLFTITSRLSDLTRELLILSELDN 303
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
188-441 |
8.61e-07 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 51.23 E-value: 8.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 188 IIKPIQSLKYATERLMHGDFDTPIKQTRTDEIG-----ILQYRfDTMRQSLKQVDAM--RQHFVQN-------------- 246
Cdd:COG4192 351 LVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGriarlLRVFR-DQAIEKTQELETEieERKRIEKnlrqtqdeliqaak 429
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 247 ----------VSHEMKTPLTHI-------HHALT-----QLQASDDKATQQT-----IINDL--FtitSRLSDLTRELLI 297
Cdd:COG4192 430 mavvgqtmtsLAHELNQPLNAMsmylfsaKKALEqenyaQLPTSLDKIEGLIermdkIIKSLrqF---SRKSDTPLQPVD 506
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 298 LSELDNASHIQLNStiqldlllqdlirheQYLIERKNIIVYAELLpssLLGNERLLHQAFENLLRNAIKYTNNEGAINIK 377
Cdd:COG4192 507 LRQVIEQAWELVES---------------RAKPQQITLHIPDDLM---VQGDQVLLEQVLVNLLVNALDAVATQPQISVD 568
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011156493 378 LQHRNNHVHFTIQNDGQ--PMTKEaqlhIFDRFYkvNSNDTSNGLGLSITQAIVQLHHGHIEVESN 441
Cdd:COG4192 569 LLSNAENLRVAISDNGNgwPLVDK----LFTPFT--TTKEVGLGLGLSICRSIMQQFGGDLYLAST 628
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-437 |
1.09e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 47.06 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYTNneGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKV-NSNDTS-NGLGLSITQAIVQ 430
Cdd:cd16950 1 LKRVLSNLVDNALRYGG--GWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGdNARGTSgTGLGLAIVQRISD 78
|
....*..
gi 1011156493 431 LHHGHIE 437
Cdd:cd16950 79 AHGGSLT 85
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
332-452 |
1.19e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 47.63 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 332 RKNIIVYAELLPS-SLLGNERLLHQAFENLLRNAIKYTNNEgaINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYK 410
Cdd:cd16954 16 RKGVSISLDISPElRFPGERNDLMELLGNLLDNACKWCLEF--VEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQR 93
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1011156493 411 VNSNDTSNGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVIL 452
Cdd:cd16954 94 LDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
343-454 |
3.25e-06 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 49.85 E-value: 3.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 343 PSSLLGNERLLHQAFENLLRNAIKYTNNeGAINIKLQHR---NNHVH--FTIQNDGQPMTKEAQLHIFDRFykvNSNDTS 417
Cdd:PRK11107 399 PDNVIGDPLRLQQIITNLVGNAIKFTES-GNIDILVELRalsNTKVQleVQIRDTGIGISERQQSQLFQAF---RQADAS 474
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1011156493 418 -------NGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILPF 454
Cdd:PRK11107 475 isrrhggTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPL 518
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
239-456 |
3.41e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 49.55 E-value: 3.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 239 MRQHFVQNVSHEMKTPLTHIHHALTQLQASDDKATQQTIINDLFTITSRLSDLTRELLILSELDNASHIQLNSTIQLDLL 318
Cdd:PRK10618 449 ARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDL 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 319 LQDLIRHEQYLIERK--NIIVYAELLPSSL-LGNERLLHQAFENLLRNAIKyTNNEGAINIKL---QHRNNHVHFTIQND 392
Cdd:PRK10618 529 IDEVLPEVLPAIKRKglQLLIHNHLKAEQLrIGDRDALRKILLLLLNYAIT-TTAYGKITLEVdqdESSPDRLTIRILDT 607
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 393 G------------QPMTKEAQlhiFDRFYKVNS------NDTSNGLGlsitqaivqlhhGHIEVESNNLIGTQFTVILPF 454
Cdd:PRK10618 608 GagvsikeldnlhFPFLNQTQ---GDRYGKASGltfflcNQLCRKLG------------GHLTIKSREGLGTRYSIHLKM 672
|
..
gi 1011156493 455 KP 456
Cdd:PRK10618 673 LA 674
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
188-386 |
4.44e-06 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 48.73 E-value: 4.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 188 IIKPIQSLKYATERLMHGDFDTPIKQTRTDEIGILQYRFDTMRQSLKQvdamRQHFVQNVSHEMKTPLTHIHHALTQLQA 267
Cdd:COG3850 142 IVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQE----LYAELEEEEELEAELELLALLDELLLLA 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 268 SDDKATQQTIINDLFTITSRLSDLTRELLILSELDNASHIQLNSTIQLDLLLQDLIRHEQYLIERKNIIVYAELLPSSLL 347
Cdd:COG3850 218 ALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLA 297
|
170 180 190
....*....|....*....|....*....|....*....
gi 1011156493 348 GNERLLHQAFENLLRNAIKYTNNEGAINIKLQHRNNHVH 386
Cdd:COG3850 298 LAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASV 336
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
353-455 |
7.19e-06 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 47.77 E-value: 7.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYTNNEGAiNIKLQHRNNHvHFTIQndGQPMTKEAQLHIFDR------------FYK-VNSNDTSNG 419
Cdd:PRK11073 238 IEQVLLNIVRNALQALGPEGG-TITLRTRTAF-QLTLH--GERYRLAARIDIEDNgpgipphlqdtlFYPmVSGREGGTG 313
|
90 100 110
....*....|....*....|....*....|....*..
gi 1011156493 420 LGLSITQAIVQLHHGHIEVESnnLIG-TQFTVILPFK 455
Cdd:PRK11073 314 LGLSIARNLIDQHSGKIEFTS--WPGhTEFSVYLPIR 348
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
353-453 |
9.68e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 44.68 E-value: 9.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 353 LHQAFENLLRNAIKYTNNEGAINIK-----------LQHRN----NHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTS 417
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIEtsnqrvdadyaLNYRDlipgNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKG 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 1011156493 418 NGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVILP 453
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
359-451 |
1.14e-05 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 47.71 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 359 NLLRNAIKYTNNegAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHIFDRFYKVNSNDTSNGLGLSITQAIVQLHHGHIEV 438
Cdd:PRK10815 385 NVLDNACKYCLE--FVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREITEQYEGKISA 462
|
90
....*....|...
gi 1011156493 439 ESNNLIGTQFTVI 451
Cdd:PRK10815 463 GDSPLGGARMEVI 475
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
357-442 |
1.63e-05 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 43.36 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 357 FENLLRNAI---KYTNNEGAINIKLQHRNNHVHFTIQNdgqpmTKEAQLHIFDRFYKVNSNDTSNGLGLSITQAIVQLHH 433
Cdd:pfam14501 10 FGNLLDNAIeacSKIDDNRFIRLKIREKQNFLIIRIEN-----TYEGELKFEGKLPSTKTKGDGHGIGLKSIRRIVKKYG 84
|
....*....
gi 1011156493 434 GHIEVESNN 442
Cdd:pfam14501 85 GNLSTEIEN 93
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
7-275 |
1.64e-05 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 47.32 E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 7 SRIAIYTITVILLSAILSFFISNVYYHFNLKPKNDQKIMTTLKNARQFDAAQQHQVSSSFFKHLADMNYQIMTVDKYGHK 86
Cdd:COG0840 25 LAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 87 HFYGADFRKDTLSATNIQRVLQGHDYHGIAKQPFQLLVTGFFDNETDNTVGVRFKSSEGYVAVFMRPDIGQTFSEFRIFL 166
Cdd:COG0840 105 LLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 167 ALLIILLLIISISLIIASTYAIIKPIQSLKYATERLMHGDFDTPIKQTRTDEIGILQYRFDTMRQSLKQVdaMRQhfVQN 246
Cdd:COG0840 185 AAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLREL--VGQ--VRE 260
|
250 260
....*....|....*....|....*....
gi 1011156493 247 VSHEMKTPLTHIHHALTQLQASddkATQQ 275
Cdd:COG0840 261 SAEQVASASEELAASAEELAAG---AEEQ 286
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
342-452 |
3.14e-05 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 43.60 E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 342 LPSSLLGNERLLHQAFENLLRNAIKYTNNEGAINIKL---------------------QHRNNHVHFT--IQNDGQPmtk 398
Cdd:cd16938 1 LPDVVVGDERRVFQVLLHMLGNLLKMRNGGGNITFRVfleggsedrsdrdwgpwrpsmSDESVEIRFEveINDSGSP--- 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1011156493 399 eAQLHIFDRFY---KVNSNDTSNGLGLSITQAIVQLHHGHIEVESNNLIGTQFTVIL 452
Cdd:cd16938 78 -SIESASMRNSlnrRYNLSELGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
360-456 |
1.86e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 43.07 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 360 LLRNAIKYTnneGA--INIKLQHRNNHVHFTIQNDGQPMTKEAQlhifdrfykvnsndTSNGLGLSITQAIVQLHHGHIE 437
Cdd:COG4585 170 ALTNALKHA---GAtrVTVTLEVDDGELTLTVRDDGVGFDPEAA--------------PGGGLGLRGMRERAEALGGTLT 232
|
90
....*....|....*....
gi 1011156493 438 VESNNLIGTQFTVILPFKP 456
Cdd:COG4585 233 IGSAPGGGTRVRATLPLAA 251
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-453 |
3.12e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 39.46 E-value: 3.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011156493 361 LRNAIKYTNnEGAINIKLQHRNNHVHFTIQNDGQPMTKEAQLHifdrfykvnsndtSNGLGLSITQAIVQLHHGHIEVES 440
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDGPAPPG-------------GGGFGLLGMRERAELLGGTLTIGS 74
|
90
....*....|...
gi 1011156493 441 NNLIGTQFTVILP 453
Cdd:cd16917 75 RPGGGTRVTARLP 87
|
|
| |
