NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|992389821|ref|WP_061076811|]
View 

MULTISPECIES: two-component response regulator DpiA [Citrobacter]

Protein Classification

response regulator( domain architecture ID 11484558)

two-component response regulator receiver similar to components of the CitA/CitB and DpiA/DpiB regulatory system

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
dpiA PRK10046
two-component response regulator DpiA; Provisional
 1-225 1.18e-176

two-component response regulator DpiA; Provisional


:

Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 483.37  E-value: 1.18e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   1 MTEPLTLLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGG 80
Cdd:PRK10046   1 MTAPLTLLIVEDETPLAEMHAEYIRHIPGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821  81 VVFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRMLAENDSASQRQIDEMFNAYARGEPKDELPTGID 160
Cdd:PRK10046  81 VVFTTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQRKHMLESIDSASQKQIDEMFNAYARGEPKDELPTGID 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 992389821 161 ALTLNAVKKLFADPQVQHTAETVAQALTISRTTARRYLEYCASRHLVIAEIVHGKVGRPQRIYHG 225
Cdd:PRK10046 161 PLTLNAVRKLFKEPGVQHTAETVAQALTISRTTARRYLEYCASRHLIIAEIVHGKVGRPQRIYHS 225
 
Name Accession Description Interval E-value
dpiA PRK10046
two-component response regulator DpiA; Provisional
 1-225 1.18e-176

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 483.37  E-value: 1.18e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   1 MTEPLTLLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGG 80
Cdd:PRK10046   1 MTAPLTLLIVEDETPLAEMHAEYIRHIPGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821  81 VVFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRMLAENDSASQRQIDEMFNAYARGEPKDELPTGID 160
Cdd:PRK10046  81 VVFTTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQRKHMLESIDSASQKQIDEMFNAYARGEPKDELPTGID 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 992389821 161 ALTLNAVKKLFADPQVQHTAETVAQALTISRTTARRYLEYCASRHLVIAEIVHGKVGRPQRIYHG 225
Cdd:PRK10046 161 PLTLNAVRKLFKEPGVQHTAETVAQALTISRTTARRYLEYCASRHLIIAEIVHGKVGRPQRIYHS 225
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 5-121 1.16e-51

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 163.18  E-value: 1.16e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   5 LTLLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFT 84
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVV 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 992389821  85 TAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRY 121
Cdd:cd19925   81 TAANDVETVREALRLGVVDYLIKPFTFERLRQRLERY 117
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 2-134 8.35e-47

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 151.28  E-value: 8.35e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   2 TEPLTLLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGV 81
Cdd:COG4565    1 MKMIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 992389821  82 VFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRMLAENDSA 134
Cdd:COG4565   81 IVITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLREDQEE 133
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 8-114 3.54e-16

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 71.41  E-value: 3.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821    8 LIVEDEMLLAEMHAEYIRHiPGFNqIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAA 87
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEK-EGYV-VAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAH 79

                          90       100
                  ....*....|....*....|....*..
gi 992389821   88 SDMETVADAVRSGAFDYLIKPIAYERL 114
Cdd:pfam00072  80 GDEDDAVEALEAGADDFLSKPFDPDEL 106
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 5-61 6.36e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 42.17  E-value: 6.36e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 992389821     5 LTLLIVEDEMLLAEMHAEYIRHiPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLP 61
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEK-EGY-EVDEATDGEEALELLKEEKPDLILLDIMMP 55
 
Name Accession Description Interval E-value
dpiA PRK10046
two-component response regulator DpiA; Provisional
 1-225 1.18e-176

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 483.37  E-value: 1.18e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   1 MTEPLTLLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGG 80
Cdd:PRK10046   1 MTAPLTLLIVEDETPLAEMHAEYIRHIPGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821  81 VVFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRMLAENDSASQRQIDEMFNAYARGEPKDELPTGID 160
Cdd:PRK10046  81 VVFTTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQRKHMLESIDSASQKQIDEMFNAYARGEPKDELPTGID 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 992389821 161 ALTLNAVKKLFADPQVQHTAETVAQALTISRTTARRYLEYCASRHLVIAEIVHGKVGRPQRIYHG 225
Cdd:PRK10046 161 PLTLNAVRKLFKEPGVQHTAETVAQALTISRTTARRYLEYCASRHLIIAEIVHGKVGRPQRIYHS 225
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 5-121 1.16e-51

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 163.18  E-value: 1.16e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   5 LTLLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFT 84
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVV 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 992389821  85 TAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRY 121
Cdd:cd19925   81 TAANDVETVREALRLGVVDYLIKPFTFERLRQRLERY 117
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 2-134 8.35e-47

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 151.28  E-value: 8.35e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   2 TEPLTLLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGV 81
Cdd:COG4565    1 MKMIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 992389821  82 VFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRMLAENDSA 134
Cdd:COG4565   81 IVITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLREDQEE 133
PRK10430 PRK10430
two-component system response regulator DcuR;
8-223 2.26e-34

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 122.52  E-value: 2.26e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   8 LIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIerFKP----GLILLDNYLPDGKGISLLHELTASHYPGGVVF 83
Cdd:PRK10430   5 LIVDDDAMVAELNRRYVAQIPGFQCCGTASTLEQAKEII--FNSdtpiDLILLDIYMQQENGLDLLPVLHEAGCKSDVIV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821  84 TTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRMLAENDSASQRQIDEMF--NAYARGEPKdELPTGIDA 161
Cdd:PRK10430  83 ISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYDQAELDQLIhgSSSNEQDPR-RLPKGLTP 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 992389821 162 LTLNAV-KKLFADPQVQHTAETVAQALTISRTTARRYLEYCASRHLVIAEIVHGKVGRPQRIY 223
Cdd:PRK10430 162 QTLRTLcQWIDAHQDYEFSTDELANAVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRY 224
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 4-150 4.48e-24

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 95.65  E-value: 4.48e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   4 PLTLLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVF 83
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 992389821  84 TTAASDMetVADAVRSGAFDYLIKPIAYERLGQTLTRYqqRRRMLAENDSASQRQIDEMFNAYARGE 150
Cdd:COG3279   81 TTAYDEY--ALEAFEVNAVDYLLKPIDEERLAKALEKA--KERLEAKAAAEASPEEKDRIFVKSGGK 143
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 3-136 2.05e-23

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 96.96  E-value: 2.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   3 EPLTLLIVEDEMLLAEMHAEYIRHIpGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVV 82
Cdd:COG2204    1 SMARILVVDDDPDIRRLLKELLERA-GY-EVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVI 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 992389821  83 FTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRMLAENDSASQ 136
Cdd:COG2204   79 LLTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRRENAEDSG 132
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 8-108 1.12e-20

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 83.05  E-value: 1.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   8 LIVEDEMLLAEMHAEYIRHIpGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAA 87
Cdd:cd00156    1 LIVDDDPAIRELLKSLLERE-GY-EVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAK 78

                         90       100
                 ....*....|....*....|.
gi 992389821  88 SDMETVADAVRSGAFDYLIKP 108
Cdd:cd00156   79 ADEEDAVRALELGADDYLVKP 99
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 6-108 1.71e-19

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 79.82  E-value: 1.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTT 85
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|...
gi 992389821  86 AASDMETVADAVRSGAFDYLIKP 108
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLKP 103
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 8-126 1.21e-17

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 75.65  E-value: 1.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   8 LIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAA 87
Cdd:cd17532    2 LIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVTAY 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 992389821  88 SdmETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRR 126
Cdd:cd17532   82 D--EYAVEAFELNAVDYLLKPFSEERLAEALAKLRKRLS 118
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 3-126 1.75e-16

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 72.96  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   3 EPLTLLIVEDEMLLAEMHAEYIRHIpGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHEL----TASHYP 78
Cdd:COG0784    4 GGKRILVVDDNPDNRELLRRLLERL-GY-EVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIralpRLPDIP 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 992389821  79 ggVVFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRR 126
Cdd:COG0784   82 --IIALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARAS 127
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 4-127 2.51e-16

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 74.22  E-value: 2.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   4 PLTLLIVEDEMLLAEMHAEYIRHIpGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVF 83
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALERE-GY-EVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIM 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 992389821  84 TTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRM 127
Cdd:COG0745   79 LTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAA 122
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 8-114 3.54e-16

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 71.41  E-value: 3.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821    8 LIVEDEMLLAEMHAEYIRHiPGFNqIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAA 87
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEK-EGYV-VAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAH 79

                          90       100
                  ....*....|....*....|....*..
gi 992389821   88 SDMETVADAVRSGAFDYLIKPIAYERL 114
Cdd:pfam00072  80 GDEDDAVEALEAGADDFLSKPFDPDEL 106
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 4-137 4.85e-16

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 73.45  E-value: 4.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   4 PLTLLIVEDEMLLAEMHAEYIRHIpGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTAsHYPGGVVF 83
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLREA-GYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISE-ERPAPVIL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 992389821  84 TTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLT----RYQQRRRMLAENDSASQR 137
Cdd:COG3707   81 LTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALElalaRFRELRALRRELAKLREA 138
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 7-126 4.90e-14

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 66.07  E-value: 4.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIRHIPgfNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTA 86
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEG--YKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 992389821  87 ASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRR 126
Cdd:cd17572   79 HGSVDIAVEAMRLGAYDFLEKPFDADRLRVTVRNALKHRK 118
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 1-131 5.83e-14

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 67.25  E-value: 5.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   1 MTEPLTLLIVEDEMLLAEMHAEYIRhIPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGG 80
Cdd:COG4567    1 SAEDRSLLLVDDDEAFARVLARALE-RRGF-EVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDAR 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 992389821  81 VVFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRMLAEN 131
Cdd:COG4567   79 IVVLTGYASIATAVEAIKLGADDYLAKPADADDLLAALERAEGDAPAPPEN 129
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 4-114 7.78e-14

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 66.86  E-value: 7.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   4 PLTLLIVEDEMLLAEMHAEYIRHIpGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHEL----TASHYPg 79
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAA-GY-EVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLradpRTADIP- 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 992389821  80 gVVFTTAASDMETVADAVRSGAFDYLIKPIAYERL 114
Cdd:COG3706   78 -IIFLTALDDEEDRARALEAGADDYLTKPFDPEEL 111
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 7-120 1.03e-13

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 65.05  E-value: 1.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEmllaEMHAEYIRHI-----PGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGV 81
Cdd:cd17536    1 VLIVDDE----PLIREGLKKLidweeLGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKI 76

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 992389821  82 VFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTR 120
Cdd:cd17536   77 IILSGYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEK 115
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 8-108 2.01e-12

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 61.27  E-value: 2.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   8 LIVEDEMLLAEMHAEYIRHIpGFNQIWlAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAA 87
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKE-GYEVDT-AADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAK 78

                         90       100
                 ....*....|....*....|.
gi 992389821  88 SDMETVADAVRSGAFDYLIKP 108
Cdd:cd17574   79 DEEEDKVLGLELGADDYITKP 99
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 3-132 4.90e-12

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 62.88  E-value: 4.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   3 EPLTLLIVEDEMLLAEMHAEYIRHIpGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHEL----TASHYP 78
Cdd:COG3437    5 QAPTVLIVDDDPENLELLRQLLRTL-GY-DVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLradpSTRDIP 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 992389821  79 ggVVFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRMLAEND 132
Cdd:COG3437   83 --VIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQRELD 134
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
1-136 7.85e-12

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 63.71  E-value: 7.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   1 MTEPLTLLIVEDE-----MLLAEMHAEYIRHIPgfnqiwlAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTAS 75
Cdd:PRK11361   1 MTAINRILIVDDEdnvrrMLSTAFALQGFETHC-------ANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSH 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 992389821  76 HYPGGVVFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRMLAENDSASQ 136
Cdd:PRK11361  74 ETRTPVILMTAYAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRALQLQSMKKEIRHLHQ 134
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 1-118 9.67e-12

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 61.97  E-value: 9.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   1 MTEPLTLLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGG 80
Cdd:PRK10651   3 NQEPATILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGR 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 992389821  81 VVFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTL 118
Cdd:PRK10651  83 IVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKAL 120
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 7-118 1.17e-11

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 59.73  E-value: 1.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLaEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTaSHYPGGVVFTTA 86
Cdd:cd19932    3 VLIAEDEALI-RMDLREMLEEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIIT-SENIAPIVLLTA 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 992389821  87 ASDMETVADAVRSGAFDYLIKPIAYERLGQTL 118
Cdd:cd19932   81 YSQQDLVERAKEAGAMAYLVKPFSESDLIPAI 112
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 6-120 1.24e-11

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 59.60  E-value: 1.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEMLLAEMhaeyIRHI---PGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVV 82
Cdd:cd17542    2 KVLIVDDAAFMRMM----LKDIltkAGYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVI 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 992389821  83 FTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTR 120
Cdd:cd17542   78 MCSAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEK 115
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 8-114 1.73e-11

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 58.96  E-value: 1.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   8 LIVEDEMLLAEMHAEYIRHIpGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGK-GISLLHELTASHY-PggVVFTT 85
Cdd:cd17534    4 LIVEDEAIIALDLKEILESL-GYEVVGIADSGEEAIELAEENKPDLILMDINLKGDMdGIEAAREIREKFDiP--VIFLT 80

                         90       100
                 ....*....|....*....|....*....
gi 992389821  86 AASDMETVADAVRSGAFDYLIKPIAYERL 114
Cdd:cd17534   81 AYSDEETLERAKETNPYGYLVKPFNEREL 109
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 6-110 1.93e-11

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 59.14  E-value: 1.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEMLLAEMHAEYIRHiPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTT 85
Cdd:cd17555    2 TILVIDDDEVVRESIAAYLED-SGF-QVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVS 79

                         90       100
                 ....*....|....*....|....*
gi 992389821  86 AASDMETVADAVRSGAFDYLIKPIA 110
Cdd:cd17555   80 GAGVMSDAVEALRLGAWDYLTKPIE 104
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 6-114 2.05e-11

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 58.90  E-value: 2.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEMLLAEMHAEYIRHiPGFNqIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTT 85
Cdd:cd17615    1 RVLVVDDEPNITELLSMALRY-EGWD-VETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLT 78

                         90       100
                 ....*....|....*....|....*....
gi 992389821  86 AASDMETVADAVRSGAFDYLIKPIAYERL 114
Cdd:cd17615   79 AKDSVEDRIAGLTAGGDDYVTKPFSLEEV 107
PRK11697 PRK11697
two-component system response regulator BtsR;
5-126 2.17e-11

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 61.40  E-value: 2.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   5 LTLLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGgVVFT 84
Cdd:PRK11697   2 IKVLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGMLDPEHMPY-IVFV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 992389821  85 TAASDMetvadAVRS---GAFDYLIKPIAYERLGQTLTRYQQRRR 126
Cdd:PRK11697  81 TAFDEY-----AIKAfeeHAFDYLLKPIDPARLAKTLARLRQERS 120
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 51-137 2.60e-11

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 60.50  E-value: 2.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821  51 PGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAASDMETVADAVRSGAFDYLIKPIAYERL----GQTLTRYQQRRR 126
Cdd:COG4566   44 PGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGHGDVPMAVRAMKAGAVDFLEKPFDDQALldavRRALARDRARRA 123

                         90
                 ....*....|.
gi 992389821 127 MLAENDSASQR 137
Cdd:COG4566  124 ERARRAELRAR 134
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 7-114 3.12e-11

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 58.28  E-value: 3.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEM----LLAEmhaeyIRHIPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVV 82
Cdd:cd17550    1 ILIVDDEEdireSLSG-----ILEDEGY-EVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVI 74

                         90       100       110
                 ....*....|....*....|....*....|..
gi 992389821  83 FTTAASDMETVADAVRSGAFDYLIKPIAYERL 114
Cdd:cd17550   75 MISGHGTIETAVKATKLGAYDFIEKPLSLDRL 106
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 6-108 4.44e-11

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 58.03  E-value: 4.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEMLLAEMHAEYIRHiPGFNQIwLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTAS----HYPggV 81
Cdd:cd17618    2 TILIVEDEPAIREMIAFNLER-AGFDVV-EAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDemtrDIP--I 77

                         90       100
                 ....*....|....*....|....*..
gi 992389821  82 VFTTAASDMETVADAVRSGAFDYLIKP 108
Cdd:cd17618   78 IMLTARGEEEDKVRGLEAGADDYITKP 104
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 6-108 4.75e-11

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 57.84  E-value: 4.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEMLLAEMHAEYI-RHipGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTAsHYPGG--VV 82
Cdd:cd17563    2 SLLLVDDDEVFAERLARALeRR--GF-EVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRA-LQPDAriVV 77

                         90       100
                 ....*....|....*....|....*.
gi 992389821  83 FTTAASdMETVADAVRSGAFDYLIKP 108
Cdd:cd17563   78 LTGYAS-IATAVEAIKLGADDYLAKP 102
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 7-114 7.45e-11

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 57.49  E-value: 7.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIRHIpGFNQIWlAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTA 86
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKA-GYAVDW-VRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTA 78

                         90       100
                 ....*....|....*....|....*...
gi 992389821  87 ASDMETVADAVRSGAFDYLIKPIAYERL 114
Cdd:cd17624   79 RDGVDDRVAGLDAGADDYLVKPFALEEL 106
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
3-138 1.00e-09

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 57.73  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   3 EPLTLLIVEDEMLLAEMHAEYIRHIpGFNqIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVV 82
Cdd:PRK10365   4 DNIDILVVDDDISHCTILQALLRGW-GYN-VALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 992389821  83 FTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTR-YQQRRRMLAENDSASQRQ 138
Cdd:PRK10365  82 IMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKaLAHTHSIDAETPAVTASQ 138
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 8-120 1.74e-09

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 53.67  E-value: 1.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   8 LIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAA 87
Cdd:cd17535    2 LIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTAH 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 992389821  88 SDMETVADAVRSGAFDYLIKPIAYERLGQTLTR 120
Cdd:cd17535   82 DDPEYVLRALKAGAAGYLLKDSSPEELIEAIRA 114
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 7-108 7.29e-09

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 51.67  E-value: 7.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEmhaeYIRHI---PGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVF 83
Cdd:cd19935    1 ILVVEDEKKLAE----YLKKGlteEGY-AVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLM 75

                         90       100
                 ....*....|....*....|....*...
gi 992389821  84 TTAASdmeTVADAVR---SGAFDYLIKP 108
Cdd:cd19935   76 LTARD---SVEDRVKgldLGADDYLVKP 100
PRK10643 PRK10643
two-component system response regulator PmrA;
7-142 9.09e-09

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 53.89  E-value: 9.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIRHiPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTA 86
Cdd:PRK10643   3 ILIVEDDTLLLQGLILALQT-EGY-ACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLILTA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 992389821  87 ASDMETVADAVRSGAFDYLIKPIAYERLgQTLTRYQQRRRmlaENDSASQRQIDEM 142
Cdd:PRK10643  81 RDTLEDRVAGLDVGADDYLVKPFALEEL-HARIRALIRRH---QGQGENELQVGNL 132
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 7-109 1.17e-08

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 51.61  E-value: 1.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYI-RHipGFN-QIWLAGNLAQARmmIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFT 84
Cdd:cd17622    3 ILLVEDDPKLARLIADFLeSH--GFNvVVEHRGDRALEV--IAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGPILLLT 78

                         90       100
                 ....*....|....*....|....*
gi 992389821  85 TAASDMETVAdAVRSGAFDYLIKPI 109
Cdd:cd17622   79 ALDSDIDHIL-GLELGADDYVVKPV 102
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 36-108 2.95e-08

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 49.84  E-value: 2.95e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 992389821  36 AGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAASDMETVADAVRSGAFDYLIKP 108
Cdd:cd19926   28 ARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITAYGSLDTAIEALKAGAFDFLTKP 100
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 7-108 3.59e-08

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 50.16  E-value: 3.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIRHiPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTA-SHYPggVVFTT 85
Cdd:cd17626    3 ILVVDDDAALAEMIGIVLRG-EGF-DPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAeSGVP--IVMLT 78

                         90       100
                 ....*....|....*....|...
gi 992389821  86 AASDMETVADAVRSGAFDYLIKP 108
Cdd:cd17626   79 AKSDTVDVVLGLESGADDYVAKP 101
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 51-131 5.98e-08

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 49.80  E-value: 5.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821  51 PGLILLDNYLPDGKGISLLHELTA--SHYPggVVFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRML 128
Cdd:cd17549   43 PGVVISDIRMPGMDGLELLAQIREldPDLP--VILITGHGDVPMAVEAMRAGAYDFLEKPFDPERLLDVVRRALEKRRLV 120


                 ...
gi 992389821 129 AEN 131
Cdd:cd17549  121 LEN 123
PRK10693 PRK10693
two-component system response regulator RssB;
34-118 8.30e-08

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 51.53  E-value: 8.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821  34 WLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAASDMETVADAVRSGAFDYLIKPIA-YE 112
Cdd:PRK10693   1 VLAANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENMADIAKALRLGVQDVLLKPVKdLN 80


                 ....*.
gi 992389821 113 RLGQTL 118
Cdd:PRK10693  81 RLREMV 86
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 7-108 1.06e-07

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 48.84  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIRhIPGFNqIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTA 86
Cdd:cd17623    1 ILLIDDDRELTELLTEYLE-MEGFN-VRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQVPVLMLTAR 78

                         90       100
                 ....*....|....*....|..
gi 992389821  87 ASDMETVAdAVRSGAFDYLIKP 108
Cdd:cd17623   79 GDDIDRIL-GLELGADDYLPKP 99
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 4-72 1.84e-07

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 48.35  E-value: 1.84e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 992389821   4 PLTLLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHEL 72
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL 69
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 7-120 2.14e-07

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 48.11  E-value: 2.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTA 86
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTV 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 992389821  87 ASDMETVADAVRSGAFDYLIKPIAYERLGQTLTR 120
Cdd:cd19931   81 SDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQ 114
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 6-109 2.80e-07

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 47.82  E-value: 2.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDE----MLLAEMhaeyIRHIPGFNqIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTAShyPGG- 80
Cdd:cd17551    2 RILIVDDNptnlLLLEAL----LRSAGYLE-VVSFTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRAL--PGLe 74

                         90       100       110
                 ....*....|....*....|....*....|..
gi 992389821  81 ---VVFTTAASDMETVADAVRSGAFDYLIKPI 109
Cdd:cd17551   75 dvpIVMITADTDREVRLRALEAGATDFLTKPF 106
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 38-108 2.89e-07

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 47.65  E-value: 2.89e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 992389821  38 NLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAASDMETVADAVRSGAFDYLIKP 108
Cdd:cd19919   32 NAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTAHSDLDSAVSAYQGGAFEYLPKP 102
PRK13435 PRK13435
response regulator; Provisional
 4-126 3.19e-07

response regulator; Provisional


Pssm-ID: 184052 [Multi-domain]  Cd Length: 145  Bit Score: 48.12  E-value: 3.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   4 PLTLLIVEDEMLLAeMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDG-KGISLLHELTASHyPGGVV 82
Cdd:PRK13435   5 QLKVLIVEDEALIA-LELEKLVEEAGHEVVGIAMSSEQAIALGRRRQPDVALVDVHLADGpTGVEVARRLSADG-GVEVV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 992389821  83 FTTAasDMETVADAVrSGAFDYLIKPIAYERLGQTLTRYQQRRR 126
Cdd:PRK13435  83 FMTG--NPERVPHDF-AGALGVIAKPYSPRGVARALSYLSARRV 123
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 7-114 3.75e-07

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 47.24  E-value: 3.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIR---HIPGFNQIwlagnlAQARMMIERFKPG--LILLDNYLPDGKGISLLHELT-ASHYPgg 80
Cdd:cd17584    2 LVVDDDPTCLAILKRMLLRcgyQVTTCTDA------EEALSMLRENKDEfdLVITDVHMPDMDGFEFLELIRlEMDLP-- 73

                         90       100       110
                 ....*....|....*....|....*....|....
gi 992389821  81 VVFTTAASDMETVADAVRSGAFDYLIKPIAYERL 114
Cdd:cd17584   74 VIMMSADGSTSTVMKGLAHGACDYLLKPVSIEDL 107
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 6-108 5.63e-07

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 46.99  E-value: 5.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEMLLAEMHAEYIRHiPGFNQIWLAgNLAQARMMIERFKPGLILLDNYLPDGKGISLLHEL-TASHYPggVVFT 84
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYLRA-AGYAPTLLA-HGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIrRFSDVP--IIMV 76

                         90       100
                 ....*....|....*....|....
gi 992389821  85 TAASDMETVADAVRSGAFDYLIKP 108
Cdd:cd19938   77 TARVEEIDRLLGLELGADDYICKP 100
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 8-108 6.29e-07

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 47.00  E-value: 6.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   8 LIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAA 87
Cdd:cd17541    4 LIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERPTPVVMVSSLT 83

                         90       100
                 ....*....|....*....|..
gi 992389821  88 S-DMETVADAVRSGAFDYLIKP 108
Cdd:cd17541   84 EeGAEITLEALELGAVDFIAKP 105
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 6-109 6.35e-07

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 46.34  E-value: 6.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDE-----MLLAEMHAEYIRhipgfnqIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTAS----H 76
Cdd:cd17538    1 KILVVDDEpanreLLEALLSAEGYE-------VLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDpetrH 73

                         90       100       110
                 ....*....|....*....|....*....|...
gi 992389821  77 YPggVVFTTAASDMETVADAVRSGAFDYLIKPI 109
Cdd:cd17538   74 IP--VIMITALDDREDRIRGLEAGADDFLSKPI 104
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 7-108 6.84e-07

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 46.65  E-value: 6.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIRhIPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTA 86
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLN-EKGY-QADVAESLKDGEYYIDIRNYDLVLVSDKLPDGNGLSIVSRIKEKHPSIVVIVLSD 78

                         90       100
                 ....*....|....*....|..
gi 992389821  87 ASDMETVADAVRSGAFDYLIKP 108
Cdd:cd17573   79 NPKTEQEIEAFKEGADDYIAKP 100
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 6-156 1.68e-06

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 47.37  E-value: 1.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEMLLAEMHAEYIRhIPGFNQIWLAgNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTA-SHYPggVVFT 84
Cdd:PRK10710  12 RILIVEDEPKLGQLLIDYLQ-AASYATTLLS-HGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRfSDIP--IVMV 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 992389821  85 TAASDMETVADAVRSGAFDYLIKPIA----YERLgQTLTRYQQRRRMLAENDSASQRQIDE-MFNAYARGEPKDELP 156
Cdd:PRK10710  88 TAKIEEIDRLLGLEIGADDYICKPYSprevVARV-KTILRRCKPQRELQQQDAESPLIIDEsRFQASWRGKMLDLTP 163
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 51-120 1.70e-06

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 45.66  E-value: 1.70e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821  51 PGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTR 120
Cdd:cd17537   45 PGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITGHGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQ 114
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 7-108 4.53e-06

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 44.30  E-value: 4.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIRHiPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTaSHYPGGVVFTTA 86
Cdd:cd17619    3 ILIVEDEPVTRATLKSYFEQ-EGY-DVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELR-EQSEVGIILVTG 79

                         90       100
                 ....*....|....*....|..
gi 992389821  87 ASDMETVADAVRSGAFDYLIKP 108
Cdd:cd17619   80 RDDEVDRIVGLEIGADDYVTKP 101
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 6-107 4.82e-06

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 46.17  E-value: 4.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEMLLAEMHAEYI-RHipGFNQIWLA-GNLAQARmmIERFKPGLILLDNYLPDGKGISLLHELTAsHYPGGVVF 83
Cdd:PRK10701   3 KIVFVEDDAEVGSLIAAYLaKH--DIDVTVEPrGDRAEAT--ILREQPDLVLLDIMLPGKDGMTICRDLRP-KWQGPIVL 77

                         90       100
                 ....*....|....*....|....*
gi 992389821  84 TTAA-SDMETVAdAVRSGAFDYLIK 107
Cdd:PRK10701  78 LTSLdSDMNHIL-ALEMGACDYILK 101
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 5-61 6.36e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 42.17  E-value: 6.36e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 992389821     5 LTLLIVEDEMLLAEMHAEYIRHiPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLP 61
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEK-EGY-EVDEATDGEEALELLKEEKPDLILLDIMMP 55
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 7-108 6.78e-06

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 43.90  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIRHiPGFN-QIWLAGNLAQARmmIERFKPGLILLDNYLPDGKGISLLHELTaSHYPGGVVFTT 85
Cdd:cd19939    2 ILIVEDELELARLTRDYLIK-AGLEvSVFTDGQRAVRR--IIDEQPSLVVLDIMLPGMDGLTVCREVR-EHSHVPILMLT 77

                         90       100
                 ....*....|....*....|...
gi 992389821  86 AASDMETVADAVRSGAFDYLIKP 108
Cdd:cd19939   78 ARTEEMDRVLGLEMGADDYLCKP 100
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 7-109 6.84e-06

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 43.65  E-value: 6.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDE----MLLAEMHAEYirhipGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTA----SHYP 78
Cdd:cd19920    1 ILIVDDVpdnlRLLSELLRAA-----GY-RVLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKAdpatRHIP 74

                         90       100       110
                 ....*....|....*....|....*....|.
gi 992389821  79 ggVVFTTAASDMETVADAVRSGAFDYLIKPI 109
Cdd:cd19920   75 --VIFLTALTDTEDKVKGFELGAVDYITKPF 103
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 36-108 9.51e-06

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 42.92  E-value: 9.51e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 992389821  36 AGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHEL-TASHYPggVVFTTAASDMETVADAVRSGAFDYLIKP 108
Cdd:cd17620   28 AETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLrEWSAVP--VIVLSARDEESDKIAALDAGADDYLTKP 99
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 51-108 1.12e-05

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 45.63  E-value: 1.12e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 992389821  51 PGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAASDMETVADAVRSGAFDYLIKP 108
Cdd:PRK10923  48 PDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHSDLDAAVSAYQQGAFDYLPKP 105
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
179-224 1.22e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 44.53  E-value: 1.22e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 992389821 179 TAETVAQALTISRTTARRYLEYCASRHLVIAEIVHGKVGRPQRIYH 224
Cdd:COG2345   29 TAAELAEALGLTPNAVRRHLDALEEEGLVERETERRGRGRPAKLYR 74
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
8-108 1.34e-05

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 44.87  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   8 LIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHyPGGVVFTTA- 86
Cdd:PRK12555   4 GIVNDSPLAVEALRRALARDPDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMAER-PCPILIVTSl 82

                         90       100
                 ....*....|....*....|...
gi 992389821  87 -ASDMETVADAVRSGAFDYLIKP 108
Cdd:PRK12555  83 tERNASRVFEAMGAGALDAVDTP 105
CitT pfam12431
Transcriptional regulator; This domain family is found in bacteria, and is approximately 30 ...
 134-162 1.67e-05

Transcriptional regulator; This domain family is found in bacteria, and is approximately 30 amino acids in length. The family is found in association with pfam00072. There is a single completely conserved residue G that may be functionally important. CitT is a transcriptional regulator which allows transcription of the citM gene which codes for the secondary transporter in the Mg-citrate transport complex.


Pssm-ID: 432549  Cd Length: 30  Bit Score: 40.54  E-value: 1.67e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 992389821  134 ASQRQIDEMFNAYARGEPKDE-LPTGIDAL 162
Cdd:pfam12431   1 VDQSDVDRLFQLQAKGAPPSGdLPKGIDKL 30
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 6-125 1.69e-05

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 44.41  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDE-----MLLAEMHAEYIRhipgfnqIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTA-SHYPg 79
Cdd:PRK10529   3 NVLIVEDEqairrFLRTALEGDGMR-------VFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQwSAIP- 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 992389821  80 gVVFTTAASDMETVADAVRSGAFDYLIKPIAYERLgQTLTRYQQRR 125
Cdd:PRK10529  75 -VIVLSARSEESDKIAALDAGADDYLSKPFGIGEL-QARLRVALRR 118
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 36-109 1.79e-05

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 42.26  E-value: 1.79e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 992389821  36 AGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAASDMETVADAVRSGAFDYLIKPI 109
Cdd:cd17565   30 ADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMISQVSDKEMIGKAYQAGIEFFINKPI 103
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 6-120 1.81e-05

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 42.53  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEMLLAEMhAEYIRHIPGFNQIWlAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTA----SHYPggV 81
Cdd:cd17548    1 KILIVEDNPLNMKL-ARDLLESAGYEVLE-AADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEdpatRDIP--V 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 992389821  82 VFTTA---ASDMETVADAvrsGAFDYLIKPIAYERLGQTLTR 120
Cdd:cd17548   77 IALTAyamKGDREKILEA---GCDGYISKPIDTREFLETVAK 115
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 6-107 1.96e-05

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 42.59  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEmllaemhaEYIRHI-------PGFNqIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYP 78
Cdd:cd17554    2 KILVVDDE--------ENIRELykeeledEGYE-VVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPD 72

                         90       100
                 ....*....|....*....|....*....
gi 992389821  79 GGVVFTTAASDMETVADAVRSGAfdYLIK 107
Cdd:cd17554   73 LPVIICTAYSEYKSDFSSWAADA--YVVK 99
PRK14084 PRK14084
DNA-binding response regulator;
8-135 2.07e-05

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 44.36  E-value: 2.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   8 LIVEDEMLlAEMHAEYI-RHIPGFNQIWLAGNLAQA--RMMIERFKpgLILLDNYLPDGKGISLLHELTASHYPGGVVFT 84
Cdd:PRK14084   4 LIVDDEPL-ARNELTYLlNEIGGFEEINEAENVKETleALLINQYD--IIFLDINLMDESGIELAAKIQKMKEPPAIIFA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 992389821  85 TAasdMETVA-DAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRMLAENDSAS 135
Cdd:PRK14084  81 TA---HDQFAvKAFELNATDYILKPFEQKRIEQAVNKVRATKAKDDNNASAI 129
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
 6-90 2.30e-05

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 42.24  E-value: 2.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEMLLAeMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDG-KGISLLHE-LTASHYPggVVF 83
Cdd:cd17540    2 RVLIIEDEPLIA-MDLEQIVEDLGHQVVGIARTRDEAVALARRERPDLILADIQLADGsSGIDAVNEiLTTHDVP--VIF 78


                 ....*..
gi 992389821  84 TTAASDM 90
Cdd:cd17540   79 VTAYPER 85
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 7-118 2.95e-05

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 42.07  E-value: 2.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIRHIpGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISL---LHELTASHYPGGVVF 83
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKL-GY-EVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEAtrrIRELEGGGRRTPIIA 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 992389821  84 TTAASDMETVADAVRSGAFDYLIKPIAYERLGQTL 118
Cdd:cd17546   79 LTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 7-108 3.93e-05

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 41.54  E-value: 3.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEmHAEYIRHIPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTA----SHYPggVV 82
Cdd:cd17598    1 ILIVEDSPTQAE-QLKHILEEQGY-KVQVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSdpdlKDIP--VI 76

                         90       100
                 ....*....|....*....|....*.
gi 992389821  83 FTTAASDMETVADAVRSGAFDYLIKP 108
Cdd:cd17598   77 LLTTLSDPRDVIRGLECGADNFITKP 102
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 7-114 4.38e-05

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 41.50  E-value: 4.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIRHIpGFNQIwLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHEL-TASHYPggVVFTT 85
Cdd:cd18159    1 ILIVEDDETIASLLKKHLEKW-GYEVV-LIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIrQISNVP--IIFIS 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 992389821  86 AASD-METVAdAVRSGAFDYLIKPIAYERL 114
Cdd:cd18159   77 SRDDnMDQVM-AINMGGDDYITKPFDLDVL 105
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 5-121 6.27e-05

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 41.27  E-value: 6.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   5 LTLLIVEDEMLLAEMHAEYIRHIpGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFT 84
Cdd:cd17530    1 LRVLVLDDDPFQCMMAATILEDL-GPGNVDEADDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNAAVILM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 992389821  85 TA--ASDMETVADAVRSGAFDYL---IKPIAYERLGQTLTRY 121
Cdd:cd17530   80 SGldGGILESAETLAGANGLNLLgtlSKPFSPEELTELLTKY 121
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 53-114 1.37e-04

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 40.09  E-value: 1.37e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 992389821  53 LILLDNYLPDGKGISLLHELTASHYPGGVVFTTAASDMETVADAVRSGAFDYLIKPIAYERL 114
Cdd:cd17616   45 IILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGLADIEDKVKGLGFGADDYMTKPFHKDEL 106
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 6-108 1.83e-04

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 39.74  E-value: 1.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEMLLAEMHAEYIRhIPGFNQIWLAGNLAQARMMIERfKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTT 85
Cdd:cd17594    1 HVLVVDDDAAMRHLLILYLR-ERGFDVTAAADGAEEARLMLHR-RVDLVLLDLRLGQESGLDLLRTIRARSDVPIIIISG 78

                         90       100
                 ....*....|....*....|...
gi 992389821  86 AASDMETVADAVRSGAFDYLIKP 108
Cdd:cd17594   79 DRRDEIDRVVGLELGADDYLAKP 101
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 8-114 1.86e-04

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 39.90  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   8 LIVEDEMLLAEMHAEYIRHiPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAA 87
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKK-EGY-TVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTAL 78

                         90       100
                 ....*....|....*....|....*..
gi 992389821  88 SDMETVADAVRSGAFDYLIKPIAYERL 114
Cdd:cd17625   79 DAVEDRVKGLDLGADDYLPKPFSLAEL 105
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 6-118 2.37e-04

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 39.71  E-value: 2.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEmllaEMHAEYIR------HIPgfNQIWLAGNLAQARMMIER-------FKPGLILLDNYLPDGKGISLLHEL 72
Cdd:cd17557    1 TILLVEDN----PGDAELIQeafkeaGVP--NELHVVRDGEEALDFLRGegeyadaPRPDLILLDLNMPRMDGFEVLREI 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 992389821  73 TAS----HYPGgVVFTTAASDmETVADAVRSGAFDYLIKPIAYERLGQTL 118
Cdd:cd17557   75 KADpdlrRIPV-VVLTTSDAE-EDIERAYELGANSYIVKPVDFEEFVEAI 122
fixJ PRK09390
response regulator FixJ; Provisional
 51-136 2.75e-04

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 40.37  E-value: 2.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821  51 PGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQRRRMLAE 130
Cdd:PRK09390  48 FGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTGHGDVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALAQAPEAAK 127


                 ....*.
gi 992389821 131 NDSASQ 136
Cdd:PRK09390 128 SEAVAA 133
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 8-118 3.55e-04

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 38.78  E-value: 3.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   8 LIVED----EMLLAEMHAEYirhipGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGK-GISLLHELTASHY---PG 79
Cdd:cd17589    2 LIVDDqptfRSMLKSMLRSL-----GVTRIDTASSGEEALRMCENKTYDIVLCDYNLGKGKnGQQLLEELRHKKLispST 76

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 992389821  80 GVVFTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTL 118
Cdd:cd17589   77 VFIMVTGESSRAMVLSALELEPDDYLLKPFTVSELRERL 115
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 7-114 6.02e-04

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 38.42  E-value: 6.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAemhAEYIRHIPGF-NQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTT 85
Cdd:cd19934    1 LLLVEDDALLA---AQLKEQLSDAgYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILT 77

                         90       100
                 ....*....|....*....|....*....
gi 992389821  86 AASDMETVADAVRSGAFDYLIKPIAYERL 114
Cdd:cd19934   78 ARDSWQDKVEGLDAGADDYLTKPFHIEEL 106
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 7-108 7.00e-04

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 37.74  E-value: 7.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIrHIPGFNQIwLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTA----SHYPggVV 82
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYL-EDQGFTVI-AASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKnadfDTIP--VI 76

                         90       100
                 ....*....|....*....|....*.
gi 992389821  83 FTTAASDMETVADAVRSGAFDYLIKP 108
Cdd:cd19927   77 FLTAKGMTSDRIKGYNAGCDGYLSKP 102
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 7-123 7.29e-04

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 38.30  E-value: 7.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDE----MLLAEMHAEyirhiPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVV 82
Cdd:cd17553    3 ILIVDDQygirILLNEVFNK-----EGY-QTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVI 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 992389821  83 FTTAASDMETVADAVRSGAFDYLIKPIAYERLGQTLTRYQQ 123
Cdd:cd17553   77 IMTAYGELDMIQESKELGALTHFAKPFDIDEIRDAVKKYLP 117
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
7-114 7.37e-04

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 39.32  E-value: 7.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAeYIRHIPGFNQIWlAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELT--ASHYPGGVVFT 84
Cdd:PRK10161   5 ILVVEDEAPIREMVC-FVLEQNGFQPVE-AEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKreSMTRDIPVVML 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 992389821  85 TAASDMETVADAVRSGAFDYLIKPIAYERL 114
Cdd:PRK10161  83 TARGEEEDRVRGLETGADDYITKPFSPKEL 112
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 7-86 1.35e-03

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 37.53  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIRHIPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTAS----HYPggVV 82
Cdd:cd17552    4 ILVIDDEEDIREVVQACLEKLAGW-EVLTASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLKKLQANpetqSIP--VI 80


                 ....
gi 992389821  83 FTTA 86
Cdd:cd17552   81 LLTA 84
pleD PRK09581
response regulator PleD; Reviewed
 6-109 1.45e-03

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 39.11  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVED-----EMLLAEMHAEYIrhipgfnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTA----SH 76
Cdd:PRK09581   4 RILVVDDipanvKLLEAKLLAEYY-------TVLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKSdpatTH 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 992389821  77 YPggVVFTTAASDmetVADAVR---SGAFDYLIKPI 109
Cdd:PRK09581  77 IP--VVMVTALDD---PEDRVRgleAGADDFLTKPI 107
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 5-114 1.74e-03

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 38.37  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   5 LTLLIVEDEMLLAEmhaeyirhipgfnqiWLAGNLAQARMMIERFKPGL-------------ILLDNYLPDGKGISLLHE 71
Cdd:PRK09836   1 MKLLIVEDEKKTGE---------------YLTKGLTEAGFVVDLADNGLngyhlamtgdydlIILDIMLPDVNGWDIVRM 65

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 992389821  72 LTASHYPGGVVFTTAASDMETVADAVRSGAFDYLIKPIAYERL 114
Cdd:PRK09836  66 LRSANKGMPILLLTALGTIEHRVKGLELGADDYLVKPFAFAEL 108
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 36-135 2.16e-03

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 36.96  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821  36 AGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHyPGGV-VFTTAASDMETVADAVR-SGAFDYLIKPIAYER 113
Cdd:cd17596   29 AASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERW-PEVVrIIISGYTDSEDIIAGINeAGIYQYLTKPWHPDQ 107

                         90       100
                 ....*....|....*....|..
gi 992389821 114 LGQTLTRYQQRRRMLAENDSAS 135
Cdd:cd17596  108 LLLTVRNAARLFELQRENERLS 129
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
4-114 2.65e-03

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 37.91  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   4 PLTLLIVEDEMLLAEMHAEYIRHIPGFNQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVF 83
Cdd:PRK10403   6 PFQVLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQIII 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 992389821  84 TT---AASDMETVADAvrsGAFDYLIKPIAYERL 114
Cdd:PRK10403  86 LTvsdASSDVFALIDA---GADGYLLKDSDPEVL 116
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 7-114 2.69e-03

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 36.63  E-value: 2.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEmllaemhaEYIRHIPGFN------QIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGG 80
Cdd:cd17614    1 ILVVDDE--------KPISDILKFNltkegyEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVPI 72

                         90       100       110
                 ....*....|....*....|....*....|....
gi 992389821  81 VVFTTAASDMETVAdAVRSGAFDYLIKPIAYERL 114
Cdd:cd17614   73 IMLTAKDSEVDKVL-GLELGADDYVTKPFSNREL 105
PRK15479 PRK15479
transcriptional regulator TctD;
14-114 3.39e-03

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 37.39  E-value: 3.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821  14 MLLAEMHAEYIRhipgfnqiWLAGNLAQARMMIERFKPG-------------LILLDNYLPDGKGISLLHELTASHYPGG 80
Cdd:PRK15479   3 LLLAEDNRELAH--------WLEKALVQNGFAVDCVFDGlaadhllqsemyaLAVLDINMPGMDGLEVLQRLRKRGQTLP 74

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 992389821  81 VVFTTAASDmetVADAVR---SGAFDYLIKPIAYERL 114
Cdd:PRK15479  75 VLLLTARSA---VADRVKglnVGADDYLPKPFELEEL 108
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 7-114 3.65e-03

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 36.21  E-value: 3.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMLLAEMHAEYIRhIPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTASHYPGGVVFTTA 86
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLR-FEGY-EVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTA 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 992389821  87 ASDmetVADAVR---SGAFDYLIKPIAYERL 114
Cdd:cd17627   79 RDS---VSDRVAgldAGADDYLVKPFALEEL 106
PRK10766 PRK10766
two-component system response regulator TorR;
6-108 4.53e-03

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 36.94  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   6 TLLIVEDEMLLAEMHAEYIRHiPGFnQIWLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHELTaSHYPGGVVFTT 85
Cdd:PRK10766   4 HILVVEDEPVTRARLQGYFEQ-EGY-TVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELR-SRSTVGIILVT 80

                         90       100
                 ....*....|....*....|...
gi 992389821  86 AASDMETVADAVRSGAFDYLIKP 108
Cdd:PRK10766  81 GRTDSIDRIVGLEMGADDYVTKP 103
orf27 CHL00148
Ycf27; Reviewed
 7-108 5.87e-03

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 37.00  E-value: 5.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821   7 LLIVEDEMllaemhaeYIRHI-------PGFNQIwLAGNLAQARMMIERFKPGLILLDNYLPDGKGISLLHEL-TASHYP 78
Cdd:CHL00148   9 ILVVDDEA--------YIRKIletrlsiIGYEVI-TASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIrKESDVP 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 992389821  79 ggVVFTTAASDMETVADAVRSGAFDYLIKP 108
Cdd:CHL00148  80 --IIMLTALGDVSDRITGLELGADDYVVKP 107
PRK11517 PRK11517
DNA-binding response regulator HprR;
32-114 8.68e-03

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 36.41  E-value: 8.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389821  32 QIWLAGNLAQARMMIERFKPG-------------LILLDNYLPDGKGISLLHEL-TASHYPggVVFTTAASDMETVADAV 97
Cdd:PRK11517  13 QEWVTQGLSEAGYVIDAVSDGrdglylalkddyaLIILDIMLPGMDGWQILQTLrTAKQTP--VICLTARDSVDDRVRGL 90

                         90
                 ....*....|....*..
gi 992389821  98 RSGAFDYLIKPIAYERL 114
Cdd:PRK11517  91 DSGANDYLVKPFSFSEL 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH