|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
11-391 |
4.41e-177 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 498.33 E-value: 4.41e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 11 VWFGCFFTGLAISQILPFLPLYISQLGVTSHEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAI 90
Cdd:cd17391 1 CWLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 91 LLQAFATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFIT 170
Cdd:cd17391 81 GLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 171 AMLLVVSFMVTLFLIKEGVRPtLKKSERLSGKAVFASLPYPALVISLFFTTLVIQLCNGSISPILALFIKSMAPDSNNIA 250
Cdd:cd17391 161 GGLLFLAFLLTLFFVKEDFKP-VEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 251 FLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLV 330
Cdd:cd17391 240 FISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 992389604 331 KYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMINICQLALVL 391
Cdd:cd17391 320 KITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
3-395 |
2.20e-164 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 467.09 E-value: 2.20e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 3 SWKVNLISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRA 82
Cdd:PRK09874 11 NWKRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 83 SLGMAIAILLQAFATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVG 162
Cdd:PRK09874 91 ALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 163 LRPVFFITAMLLVVSFMVTLFLIKEGVRPTLKKsERLSGKAVFASLPYPALVISLFFTTLVIQLCNGSISPILALFIKSM 242
Cdd:PRK09874 171 LRPVFFITASVLFLCFLVTLFCIRENFQPVSKK-EMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVREL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 243 APDSNNIAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAML 322
Cdd:PRK09874 250 AGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALL 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 992389604 323 PAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMINICQLALVLRQRR 395
Cdd:PRK09874 330 PAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLRRRR 402
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-382 |
1.83e-56 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 189.71 E-value: 1.83e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 11 VWFGCFFTGLAISQILPFLPLYISQLGVTShealsMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAI 90
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASV-----AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 91 LLQAFATNVWQLFLLRGIMGLTSG-YIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFI 169
Cdd:cd17325 76 LLFAFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 170 TAMLLVVSFMVTLFLIKEGVRPTLKKSERLSGK-AVFASLPYPALVISLFFTTLVIQLCNGSISPILALFIKSMAPDSnn 248
Cdd:cd17325 156 CAALALLALVLALLLLPEPRPPPNKRAVSAARLrSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS-- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 249 iAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTL 328
Cdd:cd17325 234 -PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLAL 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 992389604 329 LVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMI 382
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-355 |
5.72e-41 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 148.20 E-value: 5.72e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 5 KVNLISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASL 84
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA-----GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 85 GMAIAILLQAFATNVWQLFLLRGIMGLTSG-YIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGL 163
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 164 RPVFFITAMLLVVSFMVTLFLIKEGVRPtlkksERLSGKAVFASLPYPALVISLFFTTLVIQLCNGSISPILALFIKSMA 243
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPA-----ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 244 PDSnniAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLP 323
Cdd:COG2814 239 GLS---ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFP 315
|
330 340 350
....*....|....*....|....*....|..
gi 992389604 324 AVQTLLVKYSSDQITGRIFGYNQSFMYLGNVA 355
Cdd:COG2814 316 LLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
16-389 |
1.77e-34 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 130.78 E-value: 1.77e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 16 FFTGLAISQILPFLPLYISQLGVTSHEALSmwSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAF 95
Cdd:cd17330 6 FLDALGFGIVFPVLPFYVREFNKLGASGYY--VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 96 ATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLV 175
Cdd:cd17330 84 SRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 176 VSFMVTLFLIKegvrptlkkserlsgkavfaslpypaLVISLFFTTLVIQLCNGSISPILALFIKSMAPDSNniAFLSGL 255
Cdd:cd17330 164 LNLVLVLFFLP--------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSP--SQIGLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 256 IASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSD 335
Cdd:cd17330 216 LALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPS 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 992389604 336 QITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMINICQLAL 389
Cdd:cd17330 296 KEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
11-382 |
2.51e-33 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 127.71 E-value: 2.51e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 11 VWFGCFFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAI 90
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVA-----GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 91 LLQAFATNVWQLFLLRGIMGLTSGYIPNA-MALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFI 169
Cdd:cd17489 76 LLYLLATSVALLLVLRLIHGIGWGAFTTAaATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 170 TAMLLVVSFMVTLFLikeGVRPTLKKSERLSGKAVFASLPYPALVISLFFtTLVIQLCNGSISPILALFIKSMAPDSnni 249
Cdd:cd17489 156 AAVLALLALLLVFLV---KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALI-LFLASIAYGAISTFLPLYAAERGISN--- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 250 aflSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLL 329
Cdd:cd17489 229 ---AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALA 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 992389604 330 VKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMI 382
Cdd:cd17489 306 VDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLL 358
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
8-382 |
3.60e-33 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 127.67 E-value: 3.60e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA 87
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQA-----GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAFATNVWQLFLLRGIMGLT-SGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPV 166
Cdd:cd17324 76 LGNLLAALAPSFALLLLARALAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 167 FFITAMLLVVSFMVTLFLIkegvrPTLKKSERLSGKAV--FASLPYPALVISLFFTTLVIQLCNGSISPILALFIKSMAP 244
Cdd:cd17324 156 FLAIAVLALLAALLLWRLL-----PSLPPKKPGSLGLLssLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 245 DSNNiaFLSGLIASVpGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPA 324
Cdd:cd17324 231 FSSS--AIIGLLLLF-GVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSA 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 992389604 325 VQTLLVKYSSDQiTGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMI 382
Cdd:cd17324 308 LQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLL 364
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
8-384 |
7.28e-31 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 121.14 E-value: 7.28e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA 87
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQV-----GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAFATNVWQLFLLRGIMGL-TSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADhVGLRPV 166
Cdd:cd17474 76 IGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 167 FFITAMLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVFASLPypALVISLFFTTLVIQLCNGSISPILALFIKSMAPDS 246
Cdd:cd17474 155 FFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRG--RGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGIS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 247 nniAFLSGLIASVPGVSALISAPRLGK-LGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAV 325
Cdd:cd17474 233 ---PIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLL 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 992389604 326 QTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMINI 384
Cdd:cd17474 310 TTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAA 368
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-395 |
2.29e-28 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 114.20 E-value: 2.29e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA 87
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQL-----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAFATNVWQLFLLRGIMGL-TSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPV 166
Cdd:COG2271 87 LATLLFGFATSFWQLLLLRFLLGLgEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 167 FFITAMLLVVSFMVTLFLIkegvrptlkkserlsgKAVFASLPYPALVISLFFTTLVIQLCNGSISpilalfiksmapds 246
Cdd:COG2271 167 FLILGLPGLLLALLRFWLL----------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLA-------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 247 nniafLSGLIASVPGVSALISAPRLGKLGDRIGTER--ILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPA 324
Cdd:COG2271 217 -----QAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGL 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 992389604 325 VQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMINICQLALVLRQRR 395
Cdd:COG2271 292 LWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-357 |
1.64e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 108.66 E-value: 1.64e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 11 VWFGCFFTGLAISQILPFLPLYISQ-LGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIA 89
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEdLGISPTEI-----GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 90 ILLQAFATNVWQLFLLRGIMGLTSG-YIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFF 168
Cdd:pfam07690 76 LLLLLFASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 169 ITAMLLVVSFMVTLFLIKEGVRPTLKKSErlsGKAVFASLPYPALVISLFFTTLVIQLCNGSISPILALFIKSMAPDSNN 248
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAE---EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 249 IAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLR---FLLGFADGAMLPAV 325
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLlalLLLGFGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|..
gi 992389604 326 QTLLVKYSSDQITGRIFGYNQSFMYLGNVAGP 357
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-382 |
1.82e-26 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 109.24 E-value: 1.82e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 11 VWFGCFFTGLAISQILPFLPLYISQLGVTShealSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAI 90
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLS----ASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 91 LLQAFATNVWQLFLLRGIMGLTSG-YIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHvGLRPVFFI 169
Cdd:cd17329 80 ALLGFAHSPWLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 170 TAMLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVFASLPYPALVIsLFFTTLVIQLCNGSISPILALFIKSMAPDSNNI 249
Cdd:cd17329 159 AAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLL-FLLASFLISLIYFQLESTLPVYVVEILGLGESL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 250 AflsGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLL 329
Cdd:cd17329 238 L---GLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLV 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 992389604 330 VKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMI 382
Cdd:cd17329 315 AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLI 367
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
8-183 |
2.93e-25 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 105.81 E-value: 2.93e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPLYISQLGvTSHEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA 87
Cdd:cd17391 203 LISLFVTTFIIQLANQSIEPILTLYIRQLM-GDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAFATNVWQLFLLRGIMGL-TSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPV 166
Cdd:cd17391 282 LLYIPQAFVQTPWQLGILRFLLGLaTGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAV 361
|
170
....*....|....*..
gi 992389604 167 FFITAMLLVVSFMVTLF 183
Cdd:cd17391 362 FVVTALLVLLNAIWSFI 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
6-398 |
4.24e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 105.35 E-value: 4.24e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 6 VNLISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLG 85
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL-----GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 86 MAIAILLQAFATNVWQLFLLRGIMGLTSGYI-PNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLR 164
Cdd:COG2223 80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSfAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 165 PVFFITAMLLVVSFMVTLFLIKE--GVRPTLKKSERLSGKAVFASLPYPALVISLFFTTLVIqlcnGSISPILALFIKSM 242
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDppAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSF----IGFSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 243 APDSNNIAflsGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRF-LLGFADGAM 321
Cdd:COG2223 236 FGLSAATA---GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFlLLGLALGGG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 992389604 322 LPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAG-FRWVFIATAIIVMINICQLALVLRQRRNIR 398
Cdd:COG2223 313 NGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
38-382 |
4.35e-25 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 105.39 E-value: 4.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 38 VTSHEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFAT-----NVWQLFLLRGIMGLT 112
Cdd:cd06173 26 VLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 113 SG-YIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLIKEGVRP 191
Cdd:cd06173 106 SAfFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 192 TLKKSERLSG--KAVFASLPYPALVISLFFTTLVIQLCNGSISPILALFIKSMAPDSnniAFLSGLIASVPGVSALISAP 269
Cdd:cd06173 186 PGESSSLLLRdlREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGG---AAGYGLLLAAFGVGALLGAL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 270 RLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFM 349
Cdd:cd06173 263 LLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALN 342
|
330 340 350
....*....|....*....|....*....|...
gi 992389604 350 YLGNVAGPLMGATVSAMAGFRWVFIATAIIVMI 382
Cdd:cd06173 343 SGAMPLGALLAGLLADALGLSAVFLLAGALLLL 375
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
25-382 |
2.96e-23 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 100.02 E-value: 2.96e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 25 ILPFLPLYISQLGVTShEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFL 104
Cdd:cd17388 18 IMPVLPTLLREFVGDS-ADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 105 LRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHvGLRPVFFITAMLLVVSFMVTLFL 184
Cdd:cd17388 97 GRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPRAPFLVAAGLNGLNFLLGLFV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 185 IKEGVRPTLKKSERLSGKAVFASLPY-------PALVISLFFTTLVIQLCnGSISPILALFIKSMAPDSNNIAF-LSGLi 256
Cdd:cd17388 176 LPESLPPERRRAFRWRRANPFGSLRWltgfpglLGLLAVFFLIQLIGQVP-ATTWVLFTEDRFDWSPTMVGLSLaVFGL- 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 257 asvpgVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQlgVLRFLLGFADGAM-LPAVQTLLVKYSSD 335
Cdd:cd17388 254 -----LHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWM--VFPILILLALGGIaGPALQGLLSRQVPE 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 992389604 336 QITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRW---VFIATAIIVMI 382
Cdd:cd17388 327 NEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWpglAWIIGAALYLI 376
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-382 |
6.26e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 99.04 E-value: 6.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 11 VWFGCFFTGLAISQILPFLPLYISQLGVTShealsMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAI 90
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSA-----SQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 91 LLQAFATNVWQLFLLRGIMGLTSG-YIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADH--VGLRPVF 167
Cdd:cd06174 76 LLFAFAPSFWLLLLGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 168 FITAMLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVFASLPYPALVISLFFTTLVIQLCNGSISPILALFIKSMAPDSN 247
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 248 NIAFLSGLIASVPGVSALISAPRLGKLGDR-IGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQ 326
Cdd:cd06174 236 LSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 992389604 327 TLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMA-GFRWVFIATAIIVMI 382
Cdd:cd06174 316 ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATfGLTGAFLVLAVLLLL 372
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
13-366 |
2.73e-22 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 97.26 E-value: 2.73e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 13 FGCFFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILL 92
Cdd:cd17504 3 LAALAVMLVETMLSPALPTIQREFGTSAAAV-----SWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 93 QAFATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTL-ATAQISGVIGGPLmGGFIADHVGLRPVFFITA 171
Cdd:cd17504 78 AAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILsATFGIGAGIGLPL-GGWIVQHLGWRWIFWTAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 172 MLLVVSFMVTLFlikegVRPTLkkserLSGKAVFASLpypalvISLFFTTLVIQLCNGSISPILALfikSMAPDSNNIAF 251
Cdd:cd17504 157 PVAVLLAALVPL-----IDLRL-----LRRRNVLLAN------ITALLAGFGMFMVFQLLPQLLQL---PTPTGFGLGIT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 252 LSGLIASVPGVSALISAPRLGKLGDRIGTERILMA-TLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLV 330
Cdd:cd17504 218 EAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIgLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVV 297
|
330 340 350
....*....|....*....|....*....|....*.
gi 992389604 331 KYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAM 366
Cdd:cd17504 298 ESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTT 333
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-185 |
3.55e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 94.18 E-value: 3.55e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 16 FFTGLAISQILPFLPLYISQLGVTShealSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAF 95
Cdd:cd17325 209 FVLAFAFGALEPFLPLYAAELGGLS----PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 96 ATNVWQLFLLRGIMGLTSG-YIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLL 174
Cdd:cd17325 285 ATSFWLLLLLLALLGLGLGlVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALL 364
|
170
....*....|.
gi 992389604 175 VVSFMVTLFLI 185
Cdd:cd17325 365 LLAAVLFLLLR 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
8-392 |
8.25e-21 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 93.02 E-value: 8.25e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPlyisQLGVTSHEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA 87
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALP----AIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAFATNVWQLFLLRGIMGLTSGYI-PNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADhVGLRPV 166
Cdd:cd17473 77 IGGVAGLFLDSLYALLASRALLGIGVAGImTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 167 FFITAMLLVVSFMVTLFLIKegvRPTLKKSERLSGKAVFASLPyPALVISLFFTTLVIQLCNGSISPILALFIKSMAPDS 246
Cdd:cd17473 156 FLVYLLALPVLILVLLFLPE---PARKSKSAASPGAATAAALP-WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 247 nniAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQ 326
Cdd:cd17473 232 ---AALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLN 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 992389604 327 TLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMINICQLALVLR 392
Cdd:cd17473 309 SWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
15-382 |
4.51e-19 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 87.99 E-value: 4.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 15 CFFTGLAISQILPFLPLYISQ-LGVTShealsMWSGLTFSVTFLISAIVSPLWGSLADRKG-RKLMLLRASLGMAIAILL 92
Cdd:cd17471 5 TLLTGLAGAFVLPYLSLFLTEeLGASP-----LQIGIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGYLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 93 QAFATNVWQLFLLRG-IMGLTSGYIPNAMAL---VASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFF 168
Cdd:cd17471 80 FAFLRNYWVLLLVGVvLLSLGAAAFPQLFALareYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 169 ITAMLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVfaslPYPALVISLFFTTLVIQLCNGSISPILALFIksmapdSNN 248
Cdd:cd17471 160 LAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKA----PVNRRLLLLFAAFTLLFAANSMYIIAMPLYV------TNE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 249 IAFLSGLIASVPGVSALISAP---RLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLpav 325
Cdd:cd17471 230 LGGSESWVGLLFGLAAALEIPimlLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITA--- 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 992389604 326 qTLLVKYSSDQITGRIfGYNQSF----MYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMI 382
Cdd:cd17471 307 -GLGISYFQDLMPGQP-GLATTLysnaSRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALL 365
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-272 |
5.19e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 86.40 E-value: 5.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA 87
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL-----GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAFATNVWQLFLLRGIMGLTSGYI-PNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPV 166
Cdd:COG0477 91 LASLLCGLAPSPELLIAARALQGIGAGGLmPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 167 FFITAMLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVFASLPYPALVISLFFTTLVIQLCNGSISPILALFIKSMAPDS 246
Cdd:COG0477 171 FLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLAL 250
|
250 260
....*....|....*....|....*.
gi 992389604 247 NNIAFLSGLIASVPGVSALISAPRLG 272
Cdd:COG0477 251 LLLLALLLLAALLLLLLLLLLLALLL 276
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-384 |
2.36e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 86.08 E-value: 2.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA 87
Cdd:COG2807 20 LLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQA-----GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAFATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVF 167
Cdd:COG2807 95 AGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 168 FITAMLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVFASlpYPALVISLFFTtlviqlCNGSISPILALFIKSMAPDSN 247
Cdd:COG2807 175 AVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRS--PLAWLLTLFFG------LQSLLYYAVVAWLPPILRDAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 248 NIAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQT 327
Cdd:COG2807 247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALT 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 992389604 328 LLVKYSSD-QITGRIFGYNQSFMYLGNVAGP-LMGATVSAMAGFRWVFIATAIIVMINI 384
Cdd:COG2807 327 LIGLRARTpAEAAALSGMAQSVGYLLAALGPlLVGALHDATGSWTAALLLLAALAVLML 385
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
217-401 |
6.34e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 84.55 E-value: 6.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 217 LFFTTLVIQLCNGSISPILALFIKSMAPDSnniaFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFF 296
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASV----AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 297 AMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIAT 376
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170 180
....*....|....*....|....*
gi 992389604 377 AIIVMINICQLALVLRQRRNIRKRA 401
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKR 181
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
49-392 |
1.93e-17 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 83.01 E-value: 1.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 49 GLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSGYIPNA-MALVASQV 127
Cdd:cd17384 34 GLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAgMGMLASLY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 128 P--RERS---GWALSTLATaqisGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLIKegvrPTLKKSERLSGK 202
Cdd:cd17384 114 PddKERGkamGIALGGLAL----GVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQ----PSVKSEESEEGT 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 203 AVFASLPYPALVI---SLFFTTLVIQLCngsiSPILALF-IKSMAPDS--NNIAFLSgliASvpgVSALISAPRLGKLGD 276
Cdd:cd17384 186 PWKTLLKDPYILIaagAICFSNSGIAIL----EPCLPIWmMETMCPPKwqLGTAFLP---DS---IGYLIGTNLFGPLAH 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 277 RIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFA----DGAMLPAVQTLL-VKYSSdqITGRIFGYNQSFMYL 351
Cdd:cd17384 256 KIGRWLCSLLGMLLVGISLILIPLAKNIYGLIIPHFGLGLGigmvDSSMMPLLAYLVdLRHSS--VYGSVYAIADVAFCL 333
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 992389604 352 GNVAGPLMGATVSAMAGFRWVFIATAIIVMInICQLALVLR 392
Cdd:cd17384 334 AFALGPSLGGAIVKSIGFPWLMRIIGIINIL-YAPLLFFLR 373
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
13-330 |
2.16e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 82.99 E-value: 2.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 13 FGCFFTGLAISQILPFLPLYISQLGVTSHEALsmwsgLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILL 92
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQ-----WVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 93 QAFATNVWQLFLLRGIMGLTSGYI-PNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITA 171
Cdd:cd17321 78 CALAPSLAFLIAARALQGIGAAAImPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 172 MLLVVsfmvtlflikegvrptlkkserlsgkAVFASLPYPALVISLFFTTLVIqlcnGSISPILALFIKSMAPDSnniAF 251
Cdd:cd17321 158 PIGLV--------------------------ALLLARTFSGAVLAAFLLGAAL----GGLLFLLPLYLQGVLGYS---PL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 252 LSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPF---QLGVLRFLLGFADGAMLPAVQTL 328
Cdd:cd17321 205 QAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSsvwLLLPGLVLLGLGLGLFATPLTNA 284
|
..
gi 992389604 329 LV 330
Cdd:cd17321 285 AL 286
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
212-400 |
1.07e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 80.40 E-value: 1.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 212 ALVISLFFTTLVIQLCNGSISPILALFIKSMAPDsnniAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICA 291
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGAS----PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 292 VVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRW 371
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180
....*....|....*....|....*....
gi 992389604 372 VFIATAIIVMINICQLALVLRQRRNIRKR 400
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPESRPAARA 194
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
3-369 |
8.47e-16 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 78.79 E-value: 8.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 3 SWKVNLISVWFGCFFTGLAISQILPFLplYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKG-----RKL 77
Cdd:COG2211 10 KEKLAYGLGDLGLNLAFGLLSAYLLYF--YTDVLGLSAALV-----GLILLVARLWDAITDPLIGALSDRTRtrwgrRRP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 78 MLLRASLGMAIAILLQAFA------TNVWQLFLLRGIMGL--TSGYIP-NAMALVASQVPRERS-----GWALSTLATAq 143
Cdd:COG2211 83 WILIGAIPLALSFVLLFTApdlsptGKLIYALVTYLLLGLayTLVNIPySALGAELTPDYEERTrlsswRFAFAGLGGL- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 144 ISGVIGGPLMGGFIAD-HVGLRPVFFITAMLLVVSFMVTLFLIKEGVRPtlkKSERLSGKAVFASLPYPALVISLFFTTL 222
Cdd:COG2211 162 LASVLPPPLVAAFGGDaALGYRLTALIFAVLGLLAFLLTFFGTKERPVP---EEEKVSLKESLKALLKNRPFLLLLLAYL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 223 VIQLCNGSISPILALFIKSMApdsNNIAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWV- 301
Cdd:COG2211 239 LFFLALALVAALLLYYFKYVL---GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLg 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 992389604 302 -TTPFQLGVLRFLLGFADGAMLPAVQTLLV-------KYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGF 369
Cdd:COG2211 316 pGNLWLLLVLAALAGIGLGAILVLPWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGY 391
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
13-184 |
2.85e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 76.48 E-value: 2.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 13 FGCFFTGLAISQILPFLPLYISQLGVTShealsmwSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILL 92
Cdd:cd17489 201 LILFLASIAYGAISTFLPLYAAERGISN-------AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 93 QAFATNVWQLFLLRGIMGLTSG-YIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITA 171
Cdd:cd17489 274 LSFAGSPWMLLLAAVLYGLGFGlLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAA 353
|
170
....*....|...
gi 992389604 172 MLLVVSFMVTLFL 184
Cdd:cd17489 354 VVVLLALVLYIFL 366
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
13-382 |
3.11e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 76.44 E-value: 3.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 13 FGCFFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILL 92
Cdd:cd17478 3 LGHFLNDFYQGFLPALLPLLIAKLGLSYAQA-----GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 93 QAFATNVWQLFLLRGIMGLTSG-YIPNAMALvASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITA 171
Cdd:cd17478 78 LGFAPNYWLLLLLVALAGIGSAaFHPEGARL-ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 172 MLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVFASLPYP--ALVISLFFTTLVIQlcngSISPILALFIKSMapdsNNI 249
Cdd:cd17478 157 IPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRAllLLLIIVFLRSWVLS----SLTTFLPFYLVQR----GYS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 250 AFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLrFLLGFADGAMLPA----V 325
Cdd:cd17478 229 LVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVtvvlA 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 992389604 326 QTLLVKYSSdQITGRIFGYNQSfmyLGNVAGPLMGAtVSAMAGFRWVFIATAIIVMI 382
Cdd:cd17478 308 QELLPGNVG-LASGLMMGLSFG---LGGIGAPVLGA-LADAFGLESVLLILALLPLL 359
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
20-360 |
4.58e-15 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 75.73 E-value: 4.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 20 LAISQILPFLPLYISQLGVTShealsMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNV 99
Cdd:cd17390 10 FGVSMILPLLSTHIRSLGASP-----TVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 100 WQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIA-DHVGLRPVFFITAMLLVVSF 178
Cdd:cd17390 85 ALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAeTDGGFYYVALLCSAIFILNA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 179 MVTLFLIKEgvrptlkkserlsgkavfaslpYPALVISLFFTTLVIQLCNGSISpILALFIKSMAPDSNniaflsGLIAS 258
Cdd:cd17390 165 GLVWFLLSK----------------------LWDLLLVRFLMGFSVLLFRSNFS-LYLEERFDLSPKTI------GYLIS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 259 VPGVSALISAPRLGKLGDRIGTE--RILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQ 336
Cdd:cd17390 216 YSGVLGALSGFLVGRILKLYKNNeyLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSK 295
|
330 340
....*....|....*....|....
gi 992389604 337 ITGRIFGYNQSFMYLGNVAGPLMG 360
Cdd:cd17390 296 ERGTLLGVGQSVTSLARILAPLLS 319
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
57-332 |
2.64e-14 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 73.76 E-value: 2.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 57 LISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSGY-IPNAMALVASQVPRERSGWA 135
Cdd:cd17503 42 LALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 136 LSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLikegvrptlkkseRLSgkaVFAslpYPALVI 215
Cdd:cd17503 122 MGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL-------------DLR---LFK---DRNFTL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 216 SLFFTTLViQLCNGSISPILALFIKSMAPDSnniAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLF 295
Cdd:cd17503 183 GLLLSFLL-GLGLFGAMFLLPLYLQNVLGYS---AFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGT 258
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 992389604 296 FAMSWV---TTPFQLGVLRFLLGFADGAMLPAVQTLLVKY 332
Cdd:cd17503 259 LLLAFLtpdTSLWLIILPLFIRGLGMGLVFMPLNTLALNS 298
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
217-384 |
3.62e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 73.01 E-value: 3.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 217 LFFTTLVIQLCNGSISPILALFIKSMAPdSNNIAflsGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFF 296
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGG-SEAVA---GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 297 AMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIAT 376
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156
|
....*...
gi 992389604 377 AIIVMINI 384
Cdd:cd17489 157 AVLALLAL 164
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
213-382 |
3.71e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 72.98 E-value: 3.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 213 LVISLFFTTLVIQLCNGSISPILALFIKSMAPDSNNIaflsGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAV 292
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQL----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 293 VLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWV 372
Cdd:COG2271 87 LATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA 166
|
170
....*....|
gi 992389604 373 FIATAIIVMI 382
Cdd:COG2271 167 FLILGLPGLL 176
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
49-382 |
3.99e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 72.99 E-value: 3.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 49 GLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLT-SGYIPNAMALVASQV 127
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAeAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 128 PRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLIKEGVRPTLkkserlsgkaVFAS 207
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVWGLAL----------GYFG 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 208 LPYPALVISLFFTTLVIQLCNGSISPIlalfiksmapdsnniaflsGLIASVPGVSALISAPRLGKLGDRIGTER---IL 284
Cdd:cd17319 191 INYALYGLLTWLPTYLKQARGFSLKQV-------------------GLLAAIPFLAGAIGMILGGRLSDRLLRGArrlVI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 285 MATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGP-LMGATV 363
Cdd:cd17319 252 IIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPlLIGYLV 331
|
330
....*....|....*....
gi 992389604 364 SAMAGFRWVFIATAIIVMI 382
Cdd:cd17319 332 DATGSYTAAFLFLAAVALL 350
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
16-378 |
9.53e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 72.19 E-value: 9.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 16 FFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAF 95
Cdd:COG0738 18 FLWGFATALWGPLIPALKDAFGLSDAQA-----GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 96 ATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADH---VGLRPVFFITAM 172
Cdd:COG0738 93 APSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 173 LLVVSFMVTLF--LIKEGVRPTLKKSERLSGKAVFASLPYPALVISLFFTTLViQLCNGSISPILALFIKSMAPDsnnia 250
Cdd:COG0738 173 LLLLLALLFLRskLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGA-EGAIGDWLPLYLKDVLGLSEA----- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 251 fLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLV 330
Cdd:COG0738 247 -TAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLAL 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 992389604 331 KYSSDQiTGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAI 378
Cdd:COG0738 326 DGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLV 372
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
45-382 |
1.19e-13 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 71.48 E-value: 1.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 45 SMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGL-TSGYIPNAMALV 123
Cdd:cd17316 35 LLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 124 ASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGL----RPVFFITAMLLVVSFMVTLFLIkegvrptlkkseRL 199
Cdd:cd17316 115 AEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgwRILFLIGALPALLALLLRRRTL------------LL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 200 SGKAVFASLPYPalVISLFFTTLVIQLCNGSISpilalfiksmapdsnniafLSGLIASVPGVSALISAPRLGKLGDRIG 279
Cdd:cd17316 183 ILLWFFISFGYY--GLTTFLPTYLQTVLGLSPA-------------------TSSLYLLLISLGALVGALIAGLLSDRIG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 280 TERILMATLICAVVL--FFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGP 357
Cdd:cd17316 242 RKKTLVIGLILSGILalPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAP 321
|
330 340
....*....|....*....|....*....
gi 992389604 358 LMGATVSA----MAGFRWVFIATAIIVMI 382
Cdd:cd17316 322 PLIALLLAstggTGVPALILALLAIVALI 350
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
16-382 |
1.38e-13 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 71.46 E-value: 1.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 16 FFTGLAISQILPFLPLYISQLGVTSHealsmWSGLTFSVTFLISAIVSPLWGSLADR--KGRKLMLLRASLGMAIAILLQ 93
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLKQLGLSPT-----QIGILIGIRPFVRFLSAPLWGALADRfgKRKALLLLSLLAAVLFFLSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 94 AFATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERS------------GWALSTLATAQISGVIGGPlmggfiadhV 161
Cdd:cd17335 82 FVAQIFWLLLLLVILGAFFSAPVVPLVDSITLQYLGEERerygkqrlwgsiGFGIAALLVGILIDRSSTY---------K 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 162 GLRPVFFITAMLLVVSFMVTLFLIKEGVRPTlKKSERLSGKAVFASLPypalVISLFFTTLVIQLCNGSISPILALFIKs 241
Cdd:cd17335 153 NYTIAFYVFAVLMLLALLLALKFPFRPKHPE-PNENTGGLLALLRNPR----VLAFLLVAFLMGFGHGLIYSFLFWHLQ- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 242 mapDSNNIAFLSGL---IASVPGVSALISAPRLGKlgdRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFAD 318
Cdd:cd17335 227 ---DLGGSKTLIGLlwtVGVVSEIPFFFFSSRLIQ---RFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTF 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 992389604 319 GAMLPAVQTLLVKYSSDQITGRIFGYNQSFMY-LGNVAGPLMGATVSAMAGFRWVFIATAIIVMI 382
Cdd:cd17335 301 ALVWAAAVSYASAAAPPGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAIAALA 365
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
48-382 |
3.60e-13 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 70.33 E-value: 3.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 48 SGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIM---GLTSGYIpNAMALVA 124
Cdd:cd17353 40 VALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLggiGAGIGYI-TPVSTAV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 125 SQVPrERSGWAlSTLATAQI--SGVIGGPLMGGFIAdHVGLRPVFFITAMLLVVSFMVTLFLIK---EGVRPTLKKSERL 199
Cdd:cd17353 119 KWFP-DKRGLA-TGIVIAGFglGSLIFSPLIAYLIN-TVGVPTTFLILGIIFLIIIVIGAFLIRdppKGWVPPGVDPLAN 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 200 SGKAVFASLPYPALVISLFFTTLVIQLCNGS-----ISPILALFIKSMAPDSNNIAFLSgliASVPGVSALISAPRLGKL 274
Cdd:cd17353 196 NAENSPRDYTPREMLRTPTFWLLWLMFFLNAtaglmLIGQAKPIGQEFAGLDAGIAALA---VSILSIFNGGGRPFWGWL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 275 GDRIGTERILMATLICAVVLFFAMSWVT-TPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGN 353
Cdd:cd17353 273 SDKIGRKNTLSIAFLIQGVAMFLLPFIGsVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGG 352
|
330 340
....*....|....*....|....*....
gi 992389604 354 VAGPLMGATVSAMAGFRWVFIATAIIVMI 382
Cdd:cd17353 353 LIGPIIAAYVLYTGGYNAAFIIAAALSLV 381
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
49-394 |
3.64e-13 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 69.92 E-value: 3.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 49 GLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSGYI-PNAMALVASQV 127
Cdd:cd17365 37 GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAmPNAITLVSEYA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 128 PRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVtlflikegVRPTLkkserlsgkavfas 207
Cdd:cd17365 117 PARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL--------LRGTL-------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 208 lpypALVISLFFTTLVIQLCNGsispILALFIKSMAPDSNNIAFLSGLIasvpGVSALISAPRLGKLGDRIGTERILMAT 287
Cdd:cd17365 175 ----LLWVTFFMGLLLVYLLNS----WLPKLMVEAGYSLSQALTITLLL----NIGGVIGSLLLGWLADRFGPKRVLALF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 288 LICAVVLFFAMSWVTTPFqlgVLRFLLGFADGAMLPAVQTLLVKYSSD----QITGRIFGYNQSFMYLGNVAGPLMGATV 363
Cdd:cd17365 243 FALGAVSLALLGVSPASL---VLLYVLVFLAGACVNGAQVGLYALAARfyptEVRATGVGWALGVGRLGAILGPLLGGLL 319
|
330 340 350
....*....|....*....|....*....|..
gi 992389604 364 SAMA-GFRWVFIATAIIVMINICQLALVLRQR 394
Cdd:cd17365 320 LAAGlGPESVFLALAIPAALGALAVLLLRLRR 351
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
47-392 |
8.68e-13 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 69.22 E-value: 8.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 47 WSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGL--TSGYIPNAMALVA 124
Cdd:cd17355 39 VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGggAGTLAAVAFATVA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 125 SQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITA-MLLVVSFMVTLFLIK----EGVRPTLKKSERL 199
Cdd:cd17355 119 AWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLAlLALLVLVPVLLLLRRrpadLALRAYDDASPAS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 200 SG---KAVFASLPYPALVISLFF---------TTLVIQLCNGSISPILAlfiksmapdsnniaflsGLIASVPGVSALIS 267
Cdd:cd17355 199 PGstlKEALRSASFWLLALAFFLcgfavvgliVHLVPYLADRGISPAAA-----------------AVALALIGLFNIVG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 268 APRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQ-LGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQ 346
Cdd:cd17355 262 RLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLaLLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVF 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 992389604 347 SFMYLGNVAGPLMGATVSAMAG-FRWVFiatAIIVMINICQLALVLR 392
Cdd:cd17355 342 APHQLGSALGPWLGGLLYDRTGsYTAAW---ALAVALGLIAALLVLP 385
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
27-382 |
1.28e-12 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 68.40 E-value: 1.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 27 PFLPLYISQLGVTSHealsmWSGLTFSVTFLISAIVSPLWGSLADRKG-RKLMLLRASLGMAIAILLQAFATNVWQLFLL 105
Cdd:cd17490 17 PFLSPYAESLGASLS-----MIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 106 RGIMGLTSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFmVTLFLI 185
Cdd:cd17490 92 RFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGF-ILSLFI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 186 KEGVRPTLKKSERLSGKAVFASLPYpalVISLFFTTLVIQLCNGSI----SPILAlfiKSMAPDSNNIAFLSGLIASVPG 261
Cdd:cd17490 171 KEERREKKPVLTELKELLSVLKDKK---LLFFSLLAILQQMITFSTtfgfTPLIA---KQLGASSFQLGLLSIIYLLPNA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 262 VSALISAPrlgKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRI 341
Cdd:cd17490 245 LASLLSGT---LFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTA 321
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 992389604 342 FGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMI 382
Cdd:cd17490 322 MGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALL 362
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
45-388 |
1.31e-12 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 68.45 E-value: 1.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 45 SMWSGLTFsvtflisaIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSGYIPNAMALVA 124
Cdd:cd17389 71 SLFSLLQF--------LSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 125 SQVPRERSGWALSTLATAQISGVIGGPLMGGFIA-DHVGLRPVFFITA-----MLLVVSFMVTLFLIKEgvrpTLKKSER 198
Cdd:cd17389 143 DVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFAsFTRSLGEVFFSMPalfalVLALADLLFIFFFLPE----TLPSNLR 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 199 LSGKAVFASL-PYPALVISLFFttLVIQLCNGSispilalfikSMapDSNNIAFLSGLI-ASVPGVSAlisapRLGKLGD 276
Cdd:cd17389 219 RLGLVYFLYLfLFSGLEFTLTF--LTHQRFQYT----------SM--QQGKMFFFIGIImALVQGGYV-----RRIKPGK 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 277 RIGTERILMATLICAVVLfFAMSWVTTPFQLGVlrFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAG 356
Cdd:cd17389 280 EKKAVLQGLILLIPAFLL-IGWASSVTVLYAGL--FLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALG 356
|
330 340 350
....*....|....*....|....*....|..
gi 992389604 357 PLMGATVSAMAGFRWVFIATAIIVMINICQLA 388
Cdd:cd17389 357 PIVACTVYWLAGSEACYTIGALLFLLPLLLLA 388
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
47-329 |
1.50e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 68.48 E-value: 1.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 47 WSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSG-YIPNAMALVAS 125
Cdd:cd17371 35 EAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGgEWAAGAALMAE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 126 QVPRERSGWALSTLATAQISGVIGG----PLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLiKEGVRPTLKKSERLSG 201
Cdd:cd17371 115 YVPARHRGKALGYVQSGWAVGWLLAtllaALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFV-KEPPQWQAARAARRHF 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 202 K--AVFASLPYPALVISLFFTTLVIQLCNGSISPILAlFIKSMAPDSNNIAFLSGLIASVPGVSA-LISAPRLGKLGDRI 278
Cdd:cd17371 194 AdrPSLRELFSPPLLRTTLLASLLATGALGGYYGITT-WLPSYLTGERGLSFEGSAGYLVVTILGgFLGYLAGGFLADRI 272
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 992389604 279 GTERILMATLICAVVLFFAMSWVT-TPFQLGVLRFLLGFADGAMLPAVQTLL 329
Cdd:cd17371 273 GRRNNFALFALGSAISILLYFFLPlSPTLILILGFPLGFFASGPFSGMGAYL 324
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
13-379 |
1.51e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 68.35 E-value: 1.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 13 FGCFFTGLAISQILPFLPLYISQLGVTShealsMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILL 92
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVST-----ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 93 QAFATNVWQLFLLRGIMGLTSGYIPNAM-ALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIaDHVGLRPVFFITA 171
Cdd:cd17477 78 LALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV-GTAGALPFLIAAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 172 MLLVVSFMVTLFLIKEgvrPTLKKSERLSGKAVFASLPypalviSLFFTTLVIQLCNGSISPILALFIKSMAPDSNNIAf 251
Cdd:cd17477 157 LLLLALVPLLLTRRAA---PEIEEAESISLRRLLRIAP------LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAA- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 252 lsgLIASVPGVSALISAPRLGKLGDRIGTERILmatLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVK 331
Cdd:cd17477 227 ---LLLAAFVLGGLLLQWPLGWLADRFDRRRVL---LGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALA 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 992389604 332 YSSDQITG-RIFGYNQSFMY---LGNVAGPLMGATVSAMAGFRWVFIATAII 379
Cdd:cd17477 301 LAGDRLPGdELVAANAALLLlygLGSVIGPLLAGALMDAFGPHGLFLFLAAV 352
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-190 |
1.81e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 67.97 E-value: 1.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 6 VNLISVWFGCFFTGLAISQILPFLPLYISQ-LGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADR--KGRKLMLLRA 82
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQA-----GLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 83 SLGMAIAILLQAFATNVWQLFLLRGIMGLTS-GYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHV 161
Cdd:COG2271 255 LLLAALALLLLALLPSPALAIALLFLAGFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334
|
170 180
....*....|....*....|....*....
gi 992389604 162 GLRPVFFITAMLLVVSFMVTLFLIKEGVR 190
Cdd:COG2271 335 GYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
217-401 |
2.24e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 67.44 E-value: 2.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 217 LFFTTLVIQLCNGSISPILALFIKSmapDSNNIAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFF 296
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAE---DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 297 AMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIAT 376
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180
....*....|....*....|....*
gi 992389604 377 AIIVMINICQLALVLRQRRNIRKRA 401
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKP 182
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
48-382 |
3.75e-12 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 66.82 E-value: 3.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 48 SGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGL-TSGYIPNAMALVASQ 126
Cdd:cd17502 32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIgGGGLMSLAFIIIADL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 127 VP-RERSGWALSTLATAQISGVIgGPLMGGFIADHVGLRPVFFITAML-LVVSFMVTLFLIkegvrptlkkserlsgKAV 204
Cdd:cd17502 112 VPpRERGKYQGYIGAVFGIASVA-GPLIGGAFTDHLSWRWCFYINLPIgGLALALLRTILL----------------SSI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 205 FASLPYPALVISLFFttlviqlcngsiSPILALFIKSMAPDSNNIAFLSGLIASVpgVSALISAPRLGKLGDRIGTERIL 284
Cdd:cd17502 175 FGFLFGGALFGLIYY------------LPLYFQLVLGDSATKSGVRLLPLIIGLV--IGSIISGALISKTGRYKPLIVIG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 285 MATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPavQTLLVkySSDQITGRIFGYNQSFMYLGNvagpLMGATVS 364
Cdd:cd17502 241 TILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQ--QPLVA--VQNAVPPADVGVATATNTFFR----SLGGTLG 312
|
330
....*....|....*...
gi 992389604 365 amAGFRWVFIATAIIVMI 382
Cdd:cd17502 313 --VAITDVFLVALALAAL 328
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
57-187 |
4.64e-12 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 63.05 E-value: 4.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 57 LISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSGY-IPNAMALVASQVPRERSGWA 135
Cdd:TIGR00880 9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFaLVAGAALIADIYPPEERGVA 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 992389604 136 LSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLIKE 187
Cdd:TIGR00880 89 LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
16-317 |
7.02e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 66.45 E-value: 7.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 16 FFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAF 95
Cdd:cd17320 9 ALGPLAIDMYLPALPAIARDLGASASAV-----QLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 96 ATNVWQLFLLRGIMGL-TSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLL 174
Cdd:cd17320 84 ASSIEQLLIARFLQGLgAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 175 VVSFMVTLFLIKE----GVRPTLKKSERLSGKAVFASLPYPALVISLFFTTLVIqLCNGSISPIlaLFIKSMAPDSNNIA 250
Cdd:cd17320 164 LLLLLLVLLFLPEtlpeEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGL-FAYLAAAPF--IYIEQLGLSPAQFG 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 992389604 251 FLSGLIASVPGVSALISaprlGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFA 317
Cdd:cd17320 241 LLFALNAIALILGSLLN----GRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLF 303
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
53-379 |
1.39e-11 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 65.32 E-value: 1.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 53 SVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERS 132
Cdd:cd17331 42 TTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 133 GwALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVFASLPYPA 212
Cdd:cd17331 122 A-ALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPSVFNLKEI 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 213 LVI-------SLFFTTLVIQLCNGSISPILALFIKS---MAPDSNNIAFLSGLIASVpgVSALISAPRLGKLGDRIGTER 282
Cdd:cd17331 201 LRLlrlpgvaFLLLVKLLSGLPIGMFQSMFSLVAMDffgLTPEENGYLMSYAGVLGM--VVQGLLVGPLTKRFGERSLLK 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 283 ILMATLicaVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGAT 362
Cdd:cd17331 279 LSVALL---AIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGA 355
|
330
....*....|....*..
gi 992389604 363 VSAMAGFRWVFIATAII 379
Cdd:cd17331 356 LLQAYGFPSFGLLGAAI 372
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
213-384 |
3.04e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 63.68 E-value: 3.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 213 LVISLFFTTLVIQLCNGSISPILALFIKSMAPDSNNIaflsGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAV 292
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL----GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 293 VLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWV 372
Cdd:COG0477 91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170
|
170
....*....|..
gi 992389604 373 FIATAIIVMINI 384
Cdd:COG0477 171 FLINAPLGLLAL 182
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
16-378 |
3.73e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 64.10 E-value: 3.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 16 FFTGLAISQILPFLPLYISQLGVTsheALSMwsGLTFSVTFLISAIVSPLWGSLADR-KGRKLMLLRASLGMAIAILLQA 94
Cdd:cd17370 9 LFADISYEMARSILPLFLVVLGAS---AAAV--GLIEGLAEALGSLLRLFSGYLSDRtGKRKPLVILGYGLSALAKPLLA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 95 FATNVWQLFLLRgIMGLTSGYIPNAM--ALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFI--ADHVGLRPVFFIT 170
Cdd:cd17370 84 LAGSWQLVLLLR-ILERLGKGIRTPPrdALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLlyLLGGNYRTIFLLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 171 AMLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVFASLPYPALVISLFFTTLviqlcnGSISPILALFIKSMAPDSNNIA 250
Cdd:cd17370 163 AIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFAL------GNFSFAFLILRAQELGLSAALI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 251 FLSGLIASvpGVSALISAPrLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLV 330
Cdd:cd17370 237 PLLYALFN--LVYALAAYP-AGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVA 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 992389604 331 KYSSDQITGRIFGYNQSFMYLGN-VAGPLMGA---TVSAMAGFRWVFIATAI 378
Cdd:cd17370 314 DLVPAELRGTAYGLFNTVVGIGWlLASLIAGYlwdLISPSAAFLFSAVLALI 365
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
20-382 |
4.69e-11 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 63.77 E-value: 4.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 20 LAISQILPFLPLYisqlGVTSHEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNV 99
Cdd:cd17472 10 LGMFLVLPVLSVY----AKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 100 WQLFLLRGIMGltSGYIPNA-MALVASQVPRERSGWALS----TLATAQISGVIGGPLmggfIADHVGLRPVFFITAMLL 174
Cdd:cd17472 86 YGLILGRALQG--SGAISSVvMALLADLTREENRTKAMAligaSIGIAFAISMVLGPL----LAAHLGVSGLFLITAILS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 175 VVSFMVTLFLIKEGVRPTLKKSERLSGKAVFASLPYPALVISLFFTTLVIQLCNGSISPIlaLFIKSMAPDSNN-IAFLS 253
Cdd:cd17472 160 LVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPL--LLTQLGGGKGQLwKVYLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 254 GLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTtpFQLGVLRFLLGFAdgAMLPAVQTLLVKYS 333
Cdd:cd17472 238 AILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWL--LIIGLIIFFIGFN--LLEALLPSLVSKIA 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 992389604 334 SDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMI 382
Cdd:cd17472 314 PKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALL 362
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
12-395 |
5.68e-11 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 63.63 E-value: 5.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 12 WFGCFFTGLAISQILPflPLYISQLGVTSHEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRK--LMLLRASLGMAIA 89
Cdd:COG2270 20 WANSAFSTVITTFVFP--PYFTSVAALGDPAAATALWGYALAIAGLLVALLAPVLGAIADRSGRKkpFLAFFTLLGVLAT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 90 ILLQAFATNVWQLFLLR---GIMGLTSGYIPNAmALVASQVPRER------SGWAL----STLATAQISGVIGGPLMGGF 156
Cdd:COG2270 98 AALFFVAPGGLWLGLLLfvlANIGFEGSLVFYN-AFLPDIATPEEigrvsgLGWALgylgGVLLLLINLALFLKPEAFGL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 157 IADHVGLRPVFFITAMLLVVSFMVTLFLIKEGVRPTLKKSERLSG------KAVFASLP-YPALV---ISLFFTTLVIQl 226
Cdd:COG2270 177 PDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGPAPPRGAVRagfrelRRTLRELRrYRDLLrflLAYFFYRDGVQ- 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 227 cngSISPILALFIKS---MAPDSNNIAFLSGLIASVPGvsALIsaprLGKLGDRIGTERILMATLICAVVLFFAMSWVTT 303
Cdd:COG2270 256 ---TVIAFAGIYAAGvlgFSTTELIVFGLLVQIVAALG--ALL----FGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTT 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 304 PFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAG-FRWVFIATAIIVMI 382
Cdd:COG2270 327 ALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGsQRLGILSLIVFFVI 406
|
410
....*....|...
gi 992389604 383 NICQLALVLRQRR 395
Cdd:COG2270 407 GLVLLLRVKVPRG 419
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
13-187 |
1.00e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 62.59 E-value: 1.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 13 FGCFFTGLAISQILPFLPLYISQLGVTSHEALsmwsgLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILL 92
Cdd:cd17323 6 FLTFVVTFGSSIYSPALPQIAEDFHVSEEVAN-----LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 93 QAFATNVWQLFLLRGIMGLT-SGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITA 171
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFgSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170
....*....|....*.
gi 992389604 172 MLLVVSFMVTLFLIKE 187
Cdd:cd17323 161 IISGFCLILIFLFLPI 176
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
49-209 |
1.77e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 61.99 E-value: 1.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 49 GLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGL-TSGYIPNAMALVASQV 127
Cdd:TIGR00895 55 GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYA 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 128 PRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVFAS 207
Cdd:TIGR00895 135 PKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAI 214
|
..
gi 992389604 208 LP 209
Cdd:TIGR00895 215 AP 216
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
40-322 |
2.35e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 61.87 E-value: 2.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 40 SHEALSMWSGLTFSVTFlisAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGL-TSGYIPN 118
Cdd:cd17328 31 IDDSLAGLLQTVFIISY---MVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIgEASYSPI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 119 AMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHV-GLRPVFFITAMLLVVSFMVTLFLIKEGVRPTLKKSE 197
Cdd:cd17328 108 APTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 198 RLSGKA------VFASLPYPALVISLF-FTTLVIqlCNGSISPILALFIKSM----APDSNNIAFLSGLIASVPGVSALI 266
Cdd:cd17328 188 MAKSTAtsfladLKALAKNPSFILSTLgFTAVSF--VTGALAFWAPTFFLRAfgvgDLSSADVGLIFGAITCIAGVLGVL 265
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 992389604 267 SAprlGKLGDRIGTERILMATLICAVVLFfamswVTTPFQLGVLRFLLGFADGAML 322
Cdd:cd17328 266 LG---GILADRLRRKTPRADPLVCAVGLL-----AAAPFLFLALVLALSNLLLAWV 313
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
217-392 |
2.90e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 61.05 E-value: 2.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 217 LFFTTLVIQLCNGSISPILALFIKSmAPDSNNIAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFF 296
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVRE-FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 297 AMSWVTTPFQLGVLRFLLGFADGAmLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIAT 376
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVA 158
|
170
....*....|....*.
gi 992389604 377 AIIVMINICQLALVLR 392
Cdd:cd17330 159 AALALLNLVLVLFFLP 174
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
13-181 |
2.18e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 58.72 E-value: 2.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 13 FGCFFTGLAISQILPFLPLYISQLGVTSHEALSMwsgltFSVTFLISAIVSPLWGSLADRKGRKLMLLRASL-GMAIAIL 91
Cdd:cd17477 195 LGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALL-----LAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALlGALAALL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 92 LQAFATNVWQLFLLRGIMGLTSGYI-PNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFIT 170
Cdd:cd17477 270 LPLVPGLPLALLVLLFLWGGAAGPLyTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFL 349
|
170
....*....|.
gi 992389604 171 AMLLVVSFMVT 181
Cdd:cd17477 350 AAVALLFLLFL 360
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
217-380 |
2.50e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 58.34 E-value: 2.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 217 LFFTTLVIQLCNGSISPILALFIKSMAPDsnniAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFF 296
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVS----TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 297 AMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAmAGFRWVFIAT 376
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGT-AGALPFLIAA 155
|
....
gi 992389604 377 AIIV 380
Cdd:cd17477 156 VLLL 159
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
57-304 |
4.06e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 58.16 E-value: 4.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 57 LISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSG-YIPNAMALVASQVPRERSGWA 135
Cdd:TIGR00711 48 LANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGpLIPLSFSTLLNIYPPEKRGRA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 136 LSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLIKEGVRPTLKKSERLSgkAVFASLPYPALVI 215
Cdd:TIGR00711 128 MAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPAASENFDFLG--LLLLSVGLGSLLY 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 216 SL--------FFTTLVIQLCNGSISPILALFIKSMAPDSNNI-------------------------------------- 249
Cdd:TIGR00711 206 GLsegpergwFDSNEILILSITGLVAIIAFVVWELTDDNPLVdlrlfkyrnftigcvymsllglglygsfyllplylqqv 285
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 992389604 250 ----AFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTP 304
Cdd:TIGR00711 286 lgytALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILYAVGFYWRAFTFTP 344
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
8-177 |
8.55e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 56.80 E-value: 8.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA 87
Cdd:cd17478 197 LLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFA-----GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAA 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAFATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMgGFIADHVGLRPVF 167
Cdd:cd17478 272 PFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVL-GALADAFGLESVL 350
|
170
....*....|
gi 992389604 168 FITAMLLVVS 177
Cdd:cd17478 351 LILALLPLLG 360
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
49-388 |
1.30e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.09 E-value: 1.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 49 GLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSGYI-PNAMALVASQV 127
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVqPGGGRAIMRWF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 128 PRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLIKEgvrPTLKKSERLSGKAVFAS 207
Cdd:cd17475 114 PPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYRE---PPAASAATESASTLLRS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 208 LPYPALVISLFFTTLVIQLCNGSISPILALFIksmapdsnnIAFLSGLIASVPGVSALISAPRLGKLGDRIGTERI---- 283
Cdd:cd17475 191 LKEVLRNRDVWLIAIAGALLVAPQFALLTFLL---------LFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVsdrv 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 284 -----------LMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLG 352
Cdd:cd17475 262 fggrrrpvlviTAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIG 341
|
330 340 350
....*....|....*....|....*....|....*..
gi 992389604 353 NVAGPLM-GATVSAMAGFRWVFIATAIIVMINICQLA 388
Cdd:cd17475 342 IAIGPPLfGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-184 |
1.75e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.65 E-value: 1.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 12 WFGCFFTGLAISQILPFLPL-YISQLGVTSHEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASL-GMAIA 89
Cdd:cd17474 199 GLLTFLVSAFLYFFLYFAFLtYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLlLYALS 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 90 ILLQAFATNVWQLFLLRGIMGLTSG-YIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFF 168
Cdd:cd17474 279 LLLLGFVPSLALLLIAIVLFGLGLGlNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFL 358
|
170
....*....|....*.
gi 992389604 169 ITAMLLVVSFMVTLFL 184
Cdd:cd17474 359 VGAAIALAAAVLLALL 374
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
16-185 |
1.97e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 55.69 E-value: 1.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 16 FFTGLAI-SQILP------FLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRK-GRKLMLLRASLGMA 87
Cdd:cd17490 198 FFSLLAIlQQMITfsttfgFTPLIAKQLGASSFQL-----GLLSIIYLLPNALASLLSGTLFYKKlGERNTIIIGFLLLG 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAFATNVWQLFLLRGIMGLTSGYI-PNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPV 166
Cdd:cd17490 273 AYCFLIPFAPNLTLLYLLQALNGFGTGILfPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTG 352
|
170
....*....|....*....
gi 992389604 167 FFITAMLLVVSFMVTLFLI 185
Cdd:cd17490 353 FFVIGVIALLAAILSLAYY 371
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
8-382 |
2.02e-08 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 55.69 E-value: 2.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEalsmwSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA 87
Cdd:cd17385 1 LISLALANFSSMICYSILAPFFPREAEKKGVSDTI-----IGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAF-------ATNVWQLFLLRGIMGL-TSGYIPNAMALVASQVPrERSGWALSTLATAQISGVIGGPLMGGFIAD 159
Cdd:cd17385 76 GCTILFGFldrvpdgTVFIALCFLVRIVEAVgFAAFITASFAIIAKEFP-NNIATVLGTLETFSGLGLMLGPPLGGFLYQ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 160 HVGLRPVFFITAMLLVVSFMVTLFLIkegvrPTLKKSERLSGKAVFASLPYPALVISLfFTTLVIQLCNGSISPILALFI 239
Cdd:cd17385 155 AGGYELPFLVLGCLLLLTVPLNMFIL-----PRYDDDPSPKSGSMLKLLKIPSVLLLC-LSIVSGSVSLGFLDPTLSPHL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 240 KSMapdsNNIAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILM--ATLICAVVLFFAMSWVTTPFQ-----LGVLRF 312
Cdd:cd17385 229 RQF----KLSPGQVGLMFLILAGSYAISAPLWGWLSDKKKIPKWLMviGSIITGVGFLLLGPAPLLPIKselwmVIIGLV 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 313 LLGFADGAML-PAVQTLLVK-----YSSDQIT-GRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRW---VFIATAIIVMI 382
Cdd:cd17385 305 LLGLSLGAALvPTFPELLNCareygFPDNLSTyGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWaatIQAGLAFVVGI 384
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
261-385 |
2.58e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 52.27 E-value: 2.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 261 GVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGR 340
Cdd:TIGR00880 8 ALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGV 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 992389604 341 IFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVF---IATAIIVMINIC 385
Cdd:TIGR00880 88 ALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFlflAILALAAFILLA 135
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
29-197 |
2.86e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 55.07 E-value: 2.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 29 LPLYISQLGVTSHEALSMWSGltFSVTFLISAIVSplwGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGI 108
Cdd:TIGR00881 18 MPYLVEEIGLSKTDLGLLLSS--FSIAYGISKFVM---GSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 109 MGLTSGY-IPNAMALVASQVPRERSGWALSTLATAQ-ISGVIGGPLMGGFIADHVGLRPVFFITAML-LVVSFMVTLFLI 185
Cdd:TIGR00881 93 NGIFQGMgWPPCGRTVTKWFSRSERGTWVSFWNCSHnVGGGLLPPLVLFGIAELYSWHWVFIVPGIIaIIVSLICFLLLR 172
|
170
....*....|..
gi 992389604 186 KEGVRPTLKKSE 197
Cdd:TIGR00881 173 DSPQSCGLPPAE 184
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
9-183 |
3.60e-08 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 54.96 E-value: 3.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 9 ISVWFGCFFTGLAISQILPFLPLyISQLGVTSHEALSmWSGLTFSVTFLISAIVsplWGSLADRKGRKLMLLRASLGMAI 88
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPI-IGDSFGTSPNQLS-WLAASYSLTVGTFILI---FGRLGDIYGHKKMFVIGSFWFAI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 89 AILLQAFATNVWQLFLLRGIMGL-TSGYIPNAMALVA-SQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPV 166
Cdd:cd17476 76 WSLIAGFSPNFIFFIICRALQGLgPAFLLPNAMALLGrTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWI 155
|
170
....*....|....*..
gi 992389604 167 FFITAMLLVVSFMVTLF 183
Cdd:cd17476 156 FWFLAILAAIVAVAAIF 172
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
28-184 |
4.63e-08 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 54.43 E-value: 4.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 28 FLPLY-ISQLGVTSHEALSMWSgltfsVTFLISAIVSPLWGSLADRKG-RKLMLLRASLGMAIAILL-----QAFATNVW 100
Cdd:cd17337 230 FMPLYfTDTGGFSTSQWLQIWG-----IIFLVNIFFNLIFGILGDKIGwRRTVRWFGGVGCAISTLLfyyvpQLFGHNYW 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 101 QLFLLRGIMGLT-SGYIPNAmALVASQVPrERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFM 179
Cdd:cd17337 305 AALIAAILFGIGlAGFVPLS-ALMPSLAP-EHKGAAMSILNLGAGLSNFVGPAIVTLFLGSFGAGGVVWIFAGLYLLSAV 382
|
....*
gi 992389604 180 VTLFL 184
Cdd:cd17337 383 LTLFL 387
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
16-375 |
5.08e-08 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 54.17 E-value: 5.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 16 FFTGLAISQILPFLPLYISQLGVTSHEalsmwSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA----IAIL 91
Cdd:pfam12832 9 FFYFAALGCLLPYWGLYLRSIGLNPSE-----IGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAavlfLSVL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 92 LQAFATNVWQLFLLRGIM-GLTSGYIPNAMALV-------ASQVPRERS----GWALSTLATaqisgviggplmgGFIAD 159
Cdd:pfam12832 84 FIPISLTFWWLALLVVLFsFFWNAILPQFEVATlqhlgekRKDYGRQRLwgsvGFALSVFGL-------------GALFD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 160 H--VGLRPVFFitaMLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVFASLPYPALVIsLFFTTLVIQLCNGSISPILAL 237
Cdd:pfam12832 151 HysVGLLPSVL---FYLFAALMLLSLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVII-FFLAAFLLGFSHGPFYTFLFL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 238 FIKsmapdsnNIAFLSGLIASVPGVSALISAPRL---GKLGDRIGTERILMATLICAVVLFFAMSWVTtpfQLGVLRFLL 314
Cdd:pfam12832 227 YLE-------NLGASNTLLGALWALGVVAEIPLFfyaHRLLRRFGHRNLLIIALLLTALRWLLYAFFV---ENPWLVLPI 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 992389604 315 GFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSF---MY--LGNVAGPLMGATVSAMAGFRWVFIA 375
Cdd:pfam12832 297 QFLHAISFGLTHAAAIEYVRRIFPGSLQGTGQALysgLYfgLGGALGSLIGGQLWDLFGARFTFRA 362
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
222-400 |
5.62e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 54.35 E-value: 5.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 222 LVIQLCNGSISPILALFIKSMAPDSNNIAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWV 301
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 302 TTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGA--TVSAMAGFRWVFIATAII 379
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGilASSLGFGWRAVFLIAAAL 161
|
170 180
....*....|....*....|.
gi 992389604 380 VMINICQLALVLRQRRNIRKR 400
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARA 182
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
12-199 |
5.84e-08 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 54.55 E-value: 5.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 12 WFGCFFTGLAISQILPFLplyISQLGVTSheaLSMWSGLTFSVTfliSAIVSPLWGSLADRKGRKLMLLRASLGMAIAIL 91
Cdd:cd06179 7 YFAQLFGVTLPAAVLPFI---VADLGPSS---NSTWISTAWSLA---QAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 92 LQAFATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFI--ADHVGLRPVFFI 169
Cdd:cd06179 78 VAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYI 157
|
170 180 190
....*....|....*....|....*....|
gi 992389604 170 TAMLLVVSFMVTLFLIKEGVRPTLKKSERL 199
Cdd:cd06179 158 NAIFNALALILLFFFYHPPPRPQLHGSSTR 187
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
214-395 |
8.84e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.71 E-value: 8.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 214 VISLFFTTLVIQLCNGSISPILALFIKSMAPDsnniAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVV 293
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVS----VAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 294 LFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVF 373
Cdd:cd17324 77 GNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAF 156
|
170 180
....*....|....*....|..
gi 992389604 374 IATAIIVMINICQLALVLRQRR 395
Cdd:cd17324 157 LAIAVLALLAALLLWRLLPSLP 178
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
8-182 |
8.84e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.71 E-value: 8.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTglaisqILPFLPLYISQLgvtsHEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA 87
Cdd:cd17324 206 ITFLLFGGFFA------LYTYLAPFLTDV----PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAFATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVF 167
Cdd:cd17324 276 ALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355
|
170
....*....|....*
gi 992389604 168 FITAMLLVVSFMVTL 182
Cdd:cd17324 356 WVGAALLLLALLLAL 370
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
8-191 |
9.15e-08 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 53.77 E-value: 9.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPLYISQLGvTSHEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA 87
Cdd:PRK09874 221 VLSLFVTTLIIQVATGSIAPILTLYVRELA-GNVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSV 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAFATNVWQLFLLRGIMGLTSG-YIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPV 166
Cdd:PRK09874 300 LLLIPMSFVQTPLQLGILRFLLGAADGaLLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAV 379
|
170 180
....*....|....*....|....*
gi 992389604 167 FFITAMLLVVSFMVTLFLIKEGVRP 191
Cdd:PRK09874 380 FLVTAGVVLFNAVYSWNSLRRRRIP 404
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
213-401 |
2.67e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.18 E-value: 2.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 213 LVISLFFTTLVIQLCNGSISPILALFIKSMAPDsnniAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAV 292
Cdd:COG2807 19 LLLAIVLVALNLRPAITSVGPLLPEIRADLGLS----ATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 293 VLFFAMSWVTTPFQLGVLRFLLGFAdGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWV 372
Cdd:COG2807 95 AGLLLRSLAPSVALLLAGTALIGAG-IAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173
|
170 180
....*....|....*....|....*....
gi 992389604 373 FIATAIIVMINICQLALVLRQRRNIRKRA 401
Cdd:COG2807 174 LAVWALLALLALLLWLPLLRRRPAAAAAA 202
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
49-159 |
3.11e-07 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 52.33 E-value: 3.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 49 GLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGL-TSGYIPNAMALVASQV 127
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMgIGGIWVQAVVLNTEFL 209
|
90 100 110
....*....|....*....|....*....|..
gi 992389604 128 PRERSGWALSTLATAQISGVIGGPLMGGFIAD 159
Cdd:TIGR00898 210 PKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD 241
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
27-178 |
3.30e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.78 E-value: 3.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 27 PFLPLYISQLGVTShealsMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLR 106
Cdd:cd17370 220 AFLILRAQELGLSA-----ALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGF 294
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 992389604 107 GIMGLTSGYIPNAM-ALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSF 178
Cdd:cd17370 295 ILWGLYMGAQESIErAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIAL 367
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
8-298 |
5.89e-07 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 51.08 E-value: 5.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA 87
Cdd:PRK12307 20 LFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEG-----AFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAFATNVWQLFLLRGIMGL-TSGYIPNAMALVASQVPRERSGWALSTLATA-QISGVIGGPLMGGFiADHVGLRP 165
Cdd:PRK12307 95 VGTGLSGLASGVIMLTLSRFIVGMgMAGEYACASTYAVESWPKHLKSKASAFLVSGfGIGNIIAAYFMPSF-AEAYGWRA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 166 VFFITAM--LLVVSFMVTLFLIKEGVRPTLK-KSERLSGKAVFASLPYPALV----ISLFFTTLVIQLC-NGSISPILAL 237
Cdd:PRK12307 174 AFFVGLLpvLLVIYIRARAPESKEWEEAKLSgKGKHSQSAWSVFSLSMKGLFnraqFPLTLCVFIVLFSiFGANWPIFGL 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 992389604 238 FIKSMAPDSNNIAFLSGLIaSVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAM 298
Cdd:PRK12307 254 LPTYLAGEGFDTGVVSNLM-TAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPL 313
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
11-328 |
1.10e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.40 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 11 VWFGCFFTGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAI 90
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADV-----SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 91 LLQAFATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFIT 170
Cdd:cd17333 76 ALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 171 AMLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVFASLPYPALVISLFFTtlVIQLCNGSISPILALFIKSMAPDSNNIA 250
Cdd:cd17333 156 IGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGA--LALFLYVGAETAFSSWVPSYLVEKKHVS 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 992389604 251 F-LSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTL 328
Cdd:cd17333 234 DgLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSL 312
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
8-184 |
1.48e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.92 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEALsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMA 87
Cdd:cd06173 210 LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGY----GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 88 IAILLQAFATNVWQLFLLRGIMGLTSGYI-PNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPV 166
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV 365
|
170
....*....|....*...
gi 992389604 167 FFITAMLLVVSFMVTLFL 184
Cdd:cd06173 366 FLLAGALLLLAALLLLLL 383
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
8-394 |
2.60e-06 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 49.11 E-value: 2.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPLYI-SQLGVTShealsMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLR----- 81
Cdd:PRK05122 17 IVSIVMFTFISYLTIGLPLAVLPGYVhDQLGFSA-----FLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFglcgc 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 82 --ASLGMAIAILLQAFATNVWQLFLL-RGIMGLTSGYIPNAMAL-VASQVPRERSGWALSTLATAQISGV-IGGPLmGGF 156
Cdd:PRK05122 92 alSGLLYLLAGLLAAWPVLSLLLLLLgRLLLGIGESLAGTGSILwGIGRVGALHTGRVISWNGIATYGALaIGAPL-GVL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 157 IADHVGLRPVFFITAMLLVVSFmvTLFLIKEGVRPTlkKSERLSGKAVFASLPYPALVISL----FfttlviqlcnGSIS 232
Cdd:PRK05122 171 LYHWGGLAGLGLLIMLLALLGL--LLARPRPAVPPV--KGERLPFRRVLGRVWPYGMGLALasigF----------GTIA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 233 PILALFIKSMAPDSnniaflSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRF 312
Cdd:PRK05122 237 TFITLYYAARGWDG------AALALTLFGVAFVGARLLFGNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 313 LLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLG-NVAGPLMGAtVSAMAGFRWVFIATAIIVMINICqLALVL 391
Cdd:PRK05122 311 LTGFGFSLVFPALGVEAVKRVPPQNRGAALGAYSVFLDLSlGITGPLAGL-VASWFGYPSIFLAAALAALLGLA-LTWLL 388
|
...
gi 992389604 392 RQR 394
Cdd:PRK05122 389 YRR 391
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
272-382 |
2.84e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 48.70 E-value: 2.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 272 GKLGDRIGTERILMA-----TLICAVVLFFAmsWVTTPFqLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQ 346
Cdd:cd17380 55 GYLADRFGGKKVLLLavalwSLATLLTPLLA--YSSLPL-LILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVT 131
|
90 100 110
....*....|....*....|....*....|....*.
gi 992389604 347 SFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMI 382
Cdd:cd17380 132 AGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLL 167
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
38-114 |
3.35e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 48.81 E-value: 3.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 38 VTSHEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFAT---NVWQLFLLRGIMGLTSG 114
Cdd:pfam00083 38 VSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVG 117
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
51-330 |
3.99e-06 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 48.52 E-value: 3.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 51 TFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFA-----TNVWQ---LFLLRGIMGL-TSGYIPNAMA 121
Cdd:cd17368 45 TFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAptyatIGIAApllVLLARLLQGFaAGGEVGGVTA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 122 LVASQVPRERSGWALS-TLATAQISGVIGGPLmgGFIADHV---------GLRPVFFITAMLLVVSFMVTLFLIKEGVRP 191
Cdd:cd17368 125 YLVEAAPPGRRGFYTSwQSASQQVAIVAGALV--GYLLSLTltaealaewGWRIPFFIGLLIIPLGLWLRRSLEETEAFL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 192 TLKKseRLSGKAVFASLPYPALVISLFFTTLVIQLCNGSISPIL-ALFIKSMAPDSNNIAFLSGLIAsvpGVSALISAPR 270
Cdd:cd17368 203 ERKA--RPTRRELFALLANNRRIILLGMLLVAGSTVTFYFTTVYtPTYAKTVLGLSARDSFLVTLLA---GVANFIWAPL 277
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 992389604 271 LGKLGDRIGTERILM-ATLICAVVLFFAMSWVT---TPFQLGVLRFLLGFADGAMLPAVQTLLV 330
Cdd:cd17368 278 GGALSDRIGRRPVLLvITLAALVTLYPVFAWLTaapSFGRLLLVLLVLSFFFGMYGGAMVVALV 341
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
62-368 |
4.48e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 48.45 E-value: 4.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 62 VSPLWGSLADRKGRKLMLLRASLGM-AIAILLQAFATNVWQLFLLRGIMGLTSG--YIPnAMALVASQVPRERSGWALST 138
Cdd:cd06180 49 VGALLASFLRRRGRARRLIRGGLLLtVLLLAAMALTSGFAALLALRFLAGAASAfvFVF-GSNLVLHHATAAGRGHLIGL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 139 L-ATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLIKEGVRptlkkseRLSGKAVFASLPYPALvisL 217
Cdd:cd06180 128 LfAGVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPS-------APTEASAAESAPGLNR---P 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 218 FFTTLVIQLCNGSISPILALFIKSMAPDSNNIAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFA 297
Cdd:cd06180 198 LWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLL 277
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 992389604 298 MSWVTTPFQLGVLRFLLGFADGAMLPAVQTlLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAG 368
Cdd:cd06180 278 PLLSPGPAGLVLSAVLFGGTFMAITALVMA-LARELAPPAAPRALALMTASFGVGQILGPLLAGWLADATG 347
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-165 |
8.99e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.59 E-value: 8.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFFTGLAISQILPFLPLYISQ-LGVTSHealsmWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGM 86
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAA-----LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 87 AIAILLQAFA--TNVWQLFLLRGIMGLTSG-YIPNAMALVASQVP-------RERSGWALSTLATAQISGVIGGPLMGGF 156
Cdd:COG2211 305 ALGLLLLFFLgpGNLWLLLVLAALAGIGLGaILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGL 384
|
....*....
gi 992389604 157 IADHVGLRP 165
Cdd:COG2211 385 LLALFGYVA 393
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
52-310 |
1.13e-05 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 47.29 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 52 FSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQA----FAT-NVWQ---LFLLRGIMGLTSG--YIPNAMA 121
Cdd:cd17367 46 FAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAvtptYATiGIWApiiLLLARLLQGLSVGgeYGTSATY 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 122 LVASQVPRERSGWalstlATAQISGVIGGPLMG---GFIADHV---------GLRPVFFITAMLLVVSFMVTLFLIKEGV 189
Cdd:cd17367 126 LSEVAPPGRRGFY-----SSFQYVTLIGGQLLAlgvLLVLQHTlgedqmaawGWRIPFLLGGVLAVVVLWLRRGLEETES 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 190 RPTLKKSERLSGKAVFASLPYPALVISLFFTTLVIQLCNGSISPILALFIKSMAPDSNNIAFLSGLIAsvpGVSALISAP 269
Cdd:cd17367 201 FEAIAESNEASAGTLRELRRHPRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAA---LLVFMLLQP 277
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 992389604 270 RLGKLGDRIGTERILMATLICAVV----LFFAMSWVTTPFQLGVL 310
Cdd:cd17367 278 LGGRLSDRIGRRPLLLFFGIGGTLatvpLLSALDHTDSPYTAFAL 322
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
13-323 |
1.72e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 46.44 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 13 FGCFFTGLAISQILPFLPLYIsqlgvTSHEALS-MWSGLTFSVTFLISAIVSPLWGSLADRK-----GRKLMLLRASLGM 86
Cdd:cd17332 6 LGDFGNNLIFQIVSTYLLFFY-----TDVLGLSaAAAGTIFLVARIIDAINDPLMGYLIDRTrsrwgRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 87 AIAILLQ----AFATNVWQLFLLRGIMGLTSGY----IP-NAMALVASQVPRER---SGW--ALSTLATAqISGVIGGPL 152
Cdd:cd17332 81 ALLFVLLfttpDGSGTGKLIYALITYILLDLLYtlvnIPyTALIPELTDDPEERtslTSWrmFFATIGGL-LVTVLPPPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 153 MGGF--IADHVGLRPVFFITAMLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVFASL----PYPALVISLFFTTLVIQL 226
Cdd:cd17332 160 VAYFggGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALlknrPFLILLLAYLLYFLAFNI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 227 CNGsispILALFIKSMAPDSNNIAFLSGLIASVPGVsALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFq 306
Cdd:cd17332 240 VNT----VLVYYFKYVLGGRAELVLLLLLILSGALL-ALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVL- 313
|
330
....*....|....*..
gi 992389604 307 LGVLRFLLGFADGAMLP 323
Cdd:cd17332 314 ILVLAVLAGIGYGGANL 330
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
8-187 |
1.92e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.50 E-value: 1.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFF-------TGLAISQILPFLPLYISQLGvtshealsmWSGLTFSVTFLISAIVsplWGSLADRKGRKLMLL 80
Cdd:cd17312 5 FLGVFLGYAAyyvcrknFSVAKPPIVEEIGLSKDDLG---------IIGSAFLIAYAVGKFI---SGFLSDRSNIRRFMS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 81 RASLGMAIAILLQAFATNVWQLFLLRGIMGL--TSGYIPNAMALVASQVPRERSGWaLSTLATAQISGVIGGPLMGGFIA 158
Cdd:cd17312 73 AGLLLSALANIFMGFSTSLWFFAVLWGLNGLfqSMGWPPCVKLLGNWFSKKERGTV-YGIWSTSHNFGGILAPILAASLA 151
|
170 180
....*....|....*....|....*....
gi 992389604 159 DHVGLRPVFFITAMLLVVSFMVTLFLIKE 187
Cdd:cd17312 152 SYYGWRAAFLVPGIVGLVVAIILFFFLRD 180
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
4-184 |
2.70e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 45.64 E-value: 2.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 4 WKVNLISVW---FGCFFTGLAISQILPFLPLYISQLGVTSHEALSMWSgltfSVTFLISAIVSPLWGSLADR---KGRKL 77
Cdd:cd17319 174 WWFYLRQVWglaLGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLA----AIPFLAGAIGMILGGRLSDRllrGARRL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 78 MLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSG-YIPNAMALVASQVPRERSGWALSTL-ATAQISGVIGGPLMGG 155
Cdd:cd17319 250 VIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGaASPVFWSLPADLLPGEAAATAGGLInSGGNLGGFVAPLLIGY 329
|
170 180
....*....|....*....|....*....
gi 992389604 156 FIADHVGLRPVFFITAMLLVVSFMVTLFL 184
Cdd:cd17319 330 LVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
20-198 |
3.00e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 45.68 E-value: 3.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 20 LAISQILPFLPLYISQLGVTShEALSMwsglTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNV 99
Cdd:PRK11102 5 LAIDMYLPALPVIAADFGVSA-GSVQM----TLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 100 WQLFLLRGIMGLtSGYIPNAM--ALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVS 177
Cdd:PRK11102 80 DQLIYMRFLHGL-AAAAASVVinALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILA 158
|
170 180
....*....|....*....|.
gi 992389604 178 FMVTLFLIKEgvrpTLKKSER 198
Cdd:PRK11102 159 AALVFFFIPE----TLPKERR 175
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
7-182 |
3.09e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.88 E-value: 3.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 7 NLISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEALSMWSgltfSVTFLISAIVSPLWGSLADRK-GRKLMLLRASLG 85
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLL----SLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 86 MAIAILLQAFATNVWQLFLLRGIMGLT-SGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHV-GL 163
Cdd:cd06174 280 MALGLALLLLAPSLLLLLLLLLLLGFGlGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATfGL 359
|
170
....*....|....*....
gi 992389604 164 RPVFFITAMLLVVSFMVTL 182
Cdd:cd06174 360 TGAFLVLAVLLLLAAILLL 378
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
50-391 |
4.26e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 45.21 E-value: 4.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 50 LTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAI----LLQAFAT-NVWQ---LFLLRGIMGL-TSGYIPNAM 120
Cdd:cd17369 48 ATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGIATfligLLPTYAQiGILApilLVLLRLLQGLaLGGEWGGAV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 121 ALVASQVPRERSGWALS----------TLATAQISGVIGGPLMGGFIAdhVGLRPVFFITAMLLVVSFMVTLFL------ 184
Cdd:cd17369 128 LMAVEHAPPKRRGFYGSfpqlgapvglLLATGVFLLLSALLSDEAFLS--WGWRIPFLLSAVLVAVGLYIRLRLeetpvf 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 185 --IKEgvrptLKKSERLSGKAVFASLPYPALVislfftTLVIQLCNGSISPILALFIKSMAPD----SNNIAFLSGLIAS 258
Cdd:cd17369 206 rrAKE-----AGQVVRAPLVEVLRRHWRALLL------AIGLRLAENVLFYLFTTFALSYATQtlgvDRSTVLLAVLIAS 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 259 vpgVSALISAPRLGKLGDRIGTERILMA-TLICAVVLFFAMSWVTT---PFQLGVLRFLLGFADGAMLPAVQTLLVKYSS 334
Cdd:cd17369 275 ---VVAAITIPLFGWLSDRVGRRPVYLAgALLAALFAFPFFWLLDTgstWLIVLAAVVVLGVLHGMMYGPQAAFLAELFP 351
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 992389604 335 DQI--TGRIFGYNQSFMYLGnvAGPLMGATVSAMAGFRWVFIATAIIVMINICQLALVL 391
Cdd:cd17369 352 TRVryTGASLGYQLGAILGG--GFAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
49-382 |
5.85e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 44.85 E-value: 5.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 49 GLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIM-GLTSGYIPNAMALVASQV 127
Cdd:cd17352 41 AWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLgGLGLGLIYSPAIVIVGQY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 128 PRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITA--MLLVVSFMVTLFLIKEGVrptlkkserlsgkavf 205
Cdd:cd17352 121 FEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGglCLNLCVCGLLLRLLKDPT---------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 206 aslpYPALVISLFFTTLviqlcnGSISPI--LALFIKSMAPDSNNIAFLSGLIasvpGVSALISAPRLGKLGDR--IGTE 281
Cdd:cd17352 185 ----FVLLALGVSFAML------GFFVPFvyLPSYAKSLGIDESDAAFLLSII----GISDIVGRILLGLLADKprIGRL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 282 RILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAG-PLMG 360
Cdd:cd17352 251 YLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGpPIAG 330
|
330 340
....*....|....*....|..
gi 992389604 361 ATVSAMAGFRWVFIATAIIVMI 382
Cdd:cd17352 331 LLRDYTGDYDAAFYFCGACLLL 352
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
6-393 |
5.86e-05 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 45.05 E-value: 5.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 6 VNLISVWFGCFFTGLAISQILPFLPLYISQ-LGVTShealsMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASL 84
Cdd:PRK12382 15 FSLFRIAFAVFLTYMTVGLPLPVIPLFVHHdLGFGN-----TMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGML 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 85 GMAIA--------ILLQAFATNVWQLFLLRGIMG-----LTSGYIPNAMALVASQvpreRSGWALSTLATAQISGVIGGP 151
Cdd:PRK12382 90 ACGLAglayllaaILPVSAPFKFALLVVGRLILGfgesqLLTGALTWGLGLVGPK----HSGKVMSWNGMAMYGALAAGA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 152 LMGGFIADHVGLRPVFFITAML--LVVSFMVTLflikEGVRPtlKKSERLSGKAVFASLPYPALVISLFFTTLviqlcnG 229
Cdd:PRK12382 166 PLGLLLHSHFGFAALALTTMVLplLAWAFNGTV----RKVPA--HAGERPSLWSVVGLIWKPGLGLALQGVGF------A 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 230 SISPILALFIKSMAPDSNNIAFlsgliaSVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGV 309
Cdd:PRK12382 234 VIGTFVSLYFASKGWAMAGFTL------TAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 310 LRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLG-NVAGPLMGaTVSAMAGFRWVFIATAIIVMINICQLA 388
Cdd:PRK12382 308 GAALTGAGCSLIFPALGVEVVKRVPSQVRGTALGGYAAFQDIAyGVSGPLAG-MLATSFGYPSVFLAGAISAVLGIIVTI 386
|
....*
gi 992389604 389 LVLRQ 393
Cdd:PRK12382 387 LSFRR 391
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
67-382 |
6.23e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.92 E-value: 6.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 67 GSLADRKGRKLMLLRASLGMAIAILLQAFATN--VWQLFLLRGIMGLTSGYIPNAM-ALVASQVPR-ERSGWALSTLATA 142
Cdd:cd17318 77 GYLAEKYGAKRVLGYSILITALLTLLTPLAARggYGALIVLRILQGLAQGVTFPAMhALWAKWAPPlERSRLTSIAYSGS 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 143 QISGVIGGPLmGGFIADHVGLRPVFFITAMLLVVSFMVTLFLIkegvrptlkkserlsgkavfasLPYPALVISLF---- 218
Cdd:cd17318 157 QFGTVIAMPL-SGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV----------------------LPVWAIVVAHFghnw 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 219 -FTTLVIQLCNgSISPILALFIKSmapdsnniaflSGLIASVPGVSALISAPRLGKLGDRIGTERIL-------MATLIC 290
Cdd:cd17318 214 gFYTLLTELPT-YMSDVLHFNIKS-----------NGFLSSLPYLAMWICSIVGGYLADWLRSRGILstttvrkLFTSIG 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 291 AV---VLFFAMSWVTTPFQLGVLRFLL-----GFADGAMLPAVQTLLVKYSsdqitGRIFGYNQSFMYLGNVAGPLM-GA 361
Cdd:cd17318 282 FLgpgVFLIALGYLGSNATLAVVFLTLsvglsGACYSGFLVNHLDLAPNYA-----GTLMGITNTAATIAGIISPLIvGA 356
|
330 340
....*....|....*....|....
gi 992389604 362 TVS---AMAGFRWVFIATAIIVMI 382
Cdd:cd17318 357 IVKndqTIGQWRIVFFISAAIYIL 380
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
65-210 |
1.12e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 44.11 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 65 LWGSLADRKGRKLMLLrASLGM-AIAILLQAFATNVWQLFLLRGIMGLtsGYIPNAM---ALVASQVPRERSGWALSTL- 139
Cdd:PRK11043 60 LWGPLSDRYGRKPVLL-AGLSLfALGSLGMLWVESAAQLLVLRFVQAV--GVCSAAViwqALVIDRYPAQKANRVFATIm 136
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 992389604 140 -------ATAqisgviggPLMGGFIADHVGLRPVfFITAMLLVVSFMVTLFLIKEGVRPTLKKSERLSGKAVFASLPY 210
Cdd:PRK11043 137 plvalspALA--------PLLGAWLLNHFGWQAI-FATLFAITLLLILPTLRLKPSKKARKQSQDALTFKQLLKSKTY 205
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
245-382 |
1.28e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 43.90 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 245 DSNNIAFLSGLIASVPGVSALISaprlGKLGDRIGTERILMATLI-CAVVLFFaMSWVTTPFQLGVLRFLLGFADGAMLP 323
Cdd:TIGR00881 28 SKTDLGLLLSSFSIAYGISKFVM----GSVSDRSNPRVFLPIGLIlCAIVNLF-FGFSTSLWVMAALWALNGIFQGMGWP 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 324 AVQTLLVKYSSDQITGRIFG-YNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMI 382
Cdd:TIGR00881 103 PCGRTVTKWFSRSERGTWVSfWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAII 162
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
249-382 |
1.45e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.42 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 249 IAFLSGLIASVPGVSALISaprlGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTL 328
Cdd:cd17312 40 LGIIGSAFLIAYAVGKFIS----GFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKL 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 992389604 329 LVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMI 382
Cdd:cd17312 116 LGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLV 169
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
56-186 |
1.61e-04 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 43.42 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 56 FLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFAT------NVWQLFLLRGIMGLTSGY---IPNAMALVASQ 126
Cdd:cd17386 40 SIPPLFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVyfttvpSVWWFYLSAIPLALFGGFtafLSASFAYISDI 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 127 VPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLIK 186
Cdd:cd17386 120 SSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFLT 179
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
9-185 |
1.69e-04 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 43.42 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 9 ISVWFGCFFTGLAISQILPF----LPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLM-LLRAS 83
Cdd:cd17340 217 LSFWLICIICVFYYVAVFPFiglgTVFFEEKYGFSPSEA-----AAVNSIVYIISAAASPVFGFLVDKVGRNILwVLIAL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 84 LGMAIAILLQAFATnvWQLFLLRGIMGLtsGYIPNAMAL---VASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADH 160
Cdd:cd17340 292 VITLLGHLLLAFTF--VNPLIAMVIMGI--GYSMLACALwpmVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDK 367
|
170 180
....*....|....*....|....*..
gi 992389604 161 VG--LRPVFFITamLLVVSFMVTLFLI 185
Cdd:cd17340 368 KGylLLEVFFIA--CLCVSLIALIILY 392
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
272-390 |
1.97e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 43.34 E-value: 1.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 272 GKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLgfADGAMLPAV--QTLLVKYSSDQITGRIFGYNQSFM 349
Cdd:PRK11043 62 GPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQ--AVGVCSAAViwQALVIDRYPAQKANRVFATIMPLV 139
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 992389604 350 YLGNVAGPLMGATVSAMAGFRWVFIA-TAIIVMINICQLALV 390
Cdd:PRK11043 140 ALSPALAPLLGAWLLNHFGWQAIFATlFAITLLLILPTLRLK 181
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
4-151 |
2.78e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 4 WKVNLISVWFGCFFTGLAISQILPFLPLYISQLGVTShealsMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRAS 83
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSA-----LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL 272
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 992389604 84 LGMAIA----ILLQAFATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGP 151
Cdd:pfam07690 273 LLLILAalglLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
32-114 |
2.80e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.56 E-value: 2.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 32 YISQLGVTSHEALS-MWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMG 110
Cdd:cd17315 19 ALLYIAKDLGFGLStSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLG 98
|
....
gi 992389604 111 LTSG 114
Cdd:cd17315 99 LGVG 102
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
16-179 |
3.18e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 42.59 E-value: 3.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 16 FFTGLAISQILPFLPLY-ISQLGVTSHEAlsmwsGLTFSVTFLISAIV-SPLWGSLADRKGRKLMLLRASLGMAIAILLQ 93
Cdd:cd17331 217 LLSGLPIGMFQSMFSLVaMDFFGLTPEEN-----GYLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIGYLLL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 94 AFATNVWQLFLLRGIMGLtSGYIPN--AMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPV----F 167
Cdd:cd17331 292 AFVTTVWQLLVLLLPLVI-GGSVLYtvITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFgllgA 370
|
170
....*....|..
gi 992389604 168 FITAMLLVVSFM 179
Cdd:cd17331 371 AINGLLTVYLLL 382
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
277-379 |
3.53e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 42.62 E-value: 3.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 277 RIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAG 356
Cdd:cd17327 67 RFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG 146
|
90 100
....*....|....*....|....*....
gi 992389604 357 PLMGATVS------AMAGFRWVFIATAII 379
Cdd:cd17327 147 GLLAYGVFkilgvgGLAGWRWLFIIEGLI 175
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
47-183 |
4.13e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.23 E-value: 4.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 47 WSGLTFSVTFLISAIVSplwGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSG---YIPNAMALV 123
Cdd:cd17313 285 WGLLIFSLAFLIFSLPI---GKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWAtinINPYPLVSD 361
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 992389604 124 ASQVPRERSGWALSTLATA-QISGVIGGPLMGGFiaDHVGLRPVFFITAMLL-VVSFMVTLF 183
Cdd:cd17313 362 YHSESGRGQGTDTGLLNLAiSLAQILVSLLAGPI--IDVKGYGTVFPVAAVAsFLSLVGALF 421
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
16-379 |
4.44e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 42.21 E-value: 4.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 16 FFTGLAISQILPF------LPLYISQLGVtsheALSmWSGLTfSVTFLISAIvSPLWGSLADRKG------RKLMLLRAS 83
Cdd:cd17485 1 LLFGLYLAQGLPYgfqsqaLPVLLRSAGV----SLT-AIGLL-KLLYLPWVL-KFLWAPLVDRYGlprlgrRRSWLLPTQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 84 LGMAIAILLQAF---ATNVWQLFLLRGIMGLTSGYIPNAM-ALVASQVPRERSGWAlstlATAQISGVIGGPLMGGFIA- 158
Cdd:cd17485 74 LGLALLLLALAFlppTTNLLAFLGLLFLLNLFSATQDIATdGLAVELLTPEERGLG----NAAQVVGYKLGSLLGGGGLl 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 159 ---DHVGLRPVFFITAMLLVVSFMVTLFL--IKEGVRPTLKKSERLSGKAVFASLPYPALVISLFFTtLVIQLCNGSISP 233
Cdd:cd17485 150 wlyDLIGWQSLLLSLAALYLLLLLPVLFLreLELPQQPPASERGAALKASLRAFLRRPGTRWLLLFL-LLYKLGEQGALA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 234 ILALFIKSMAPDSNNIAFLSGLIASVPGVSALISAPRLGKLGDRIGTERI--LMATLICAVVLFFAMSWVT-TPFQLGVL 310
Cdd:cd17485 229 MLPPFLVDRGFSLSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLggLLRLLLLGLYTLLALGGSGlNWVLLLAS 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 992389604 311 RFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAII 379
Cdd:cd17485 309 LALLHLVGGMITTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAIL 377
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
67-186 |
4.58e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 42.16 E-value: 4.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 67 GSLADRKGRKLMLLRASLGMAIAILL--QAFATNVWQLFLLRGIMGLTSGYIPNAMA-LVASQVPRERSGWALSTLATAQ 143
Cdd:cd17380 55 GYLADRFGGKKVLLLAVALWSLATLLtpLLAYSSLPLLILSRILLGLGEGVHFPSMTsLFSRWVPVSERSRAVSIVTAGS 134
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 992389604 144 ISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLIK 186
Cdd:cd17380 135 YLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP 177
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
9-316 |
5.81e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 41.60 E-value: 5.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 9 ISVWFGCFF--TGLAISQILPFLPLYISQLGVTShEALSMwsglTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGM 86
Cdd:TIGR00710 6 FALLLGCLSilGPLGIDMYLPAFPEIAADLSTPA-SIVQM----TLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 87 AIAILLQAFATNVWQLFLLRGIMGLT-SGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRP 165
Cdd:TIGR00710 81 ALSSLGLALSNNIETLLVLRFVQAFGaSAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 166 VFFITAMLLVVSFMVTLFLIKEgvrpTLKKSERLSGKAVFASLPYPALVISLFFTTLVIQLCNG------SISPILALFI 239
Cdd:TIGR00710 161 IFAFLSLAGILLSALIFFILPE----TLPYEARIQISTYFETFLLLLKSKMFWGYALIYGASFGgffaffSGAPFVYIDI 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 992389604 240 KSMAPDSNNIAFLSGLIASVPGvsalisaprlGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGF 316
Cdd:TIGR00710 237 MGVSPSVFGLLFALNIIAMIFG----------GFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMI 303
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
254-379 |
7.38e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 41.41 E-value: 7.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 254 GLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFFAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYS 333
Cdd:cd17358 44 SWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIA 123
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 992389604 334 SDQITGRiFGynqSFMYLGNVAGPLMGATVSAMAGFRWVFIATAII 379
Cdd:cd17358 124 PKNVRGA-LG---SLNQLLVNIGILLGYVLGSFLPWRTLALIGAIP 165
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
50-190 |
7.50e-04 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 41.34 E-value: 7.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 50 LTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSGYIPNAMALVASQVPR 129
Cdd:cd17441 38 LLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVTLYAEFLPM 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 992389604 130 ERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLLVVsFMVTLFLIKEGVR 190
Cdd:cd17441 118 KSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLI-FAVLCFWLPESAR 177
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
68-176 |
8.17e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 41.09 E-value: 8.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 68 SLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGL-TSGYIPNAMALVASQvPRERSGWALSTLATAQISG 146
Cdd:cd17393 257 RLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLgLSVVVPLAFSAAGAL-PGLAAGIAVARVATLGYLG 335
|
90 100 110
....*....|....*....|....*....|
gi 992389604 147 VIGGPLMGGFIADHVGLRPVFFITAMLLVV 176
Cdd:cd17393 336 FLVGPPLIGFLADATGLRTAFLVVALLALL 365
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
16-393 |
8.92e-04 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 41.04 E-value: 8.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 16 FFTGLAISQILPFLPLYISQLgvtSHEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIA-----I 90
Cdd:cd17326 9 FLSSLQFSIVLTSIWPYLQKI---DPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVgnilyA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 91 LLQAFATNV-WQLFLLRGIMGLTSGYIPNAMALVA-SQVPRERSGwALSTLATAQISGVIGGPLMGG---FIADHVGLRP 165
Cdd:cd17326 86 LAEYFPSNRkYVMLVARFLIGVGAGNVAVLRAYVAaASTLKDRTR-AMAVISAAQALGFIVGPALQAaftPIGYPGYVIG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 166 VFF----------ITAMLLVVSFMVTLFLIKEGVrptlkkserlsgkavfaslpypalVISLFFTTLVIQLCNGSISPIL 235
Cdd:cd17326 165 IKLrfnmytapawLMAILGIINIILILFFFKEVV------------------------CIFLFFVVLFIFANLETIGTPL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 236 alFIKSMAPDSNNIAFLSGLIASVPGVSA-----LISAPRLGKLGDRIgterilmaTLICAVVLFFAMSWVTTPFQLgVL 310
Cdd:cd17326 221 --TMDMYGWTREEAVLYNGIILAVSGVLSvlvflLFKFLSLGLIDERK--------ILLGGLILFFLGFVVTLPWGI-TG 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 311 RFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIATAIIVMINICQLALV 390
Cdd:cd17326 290 VILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVF 369
|
...
gi 992389604 391 LRQ 393
Cdd:cd17326 370 YKR 372
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
47-301 |
1.07e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 41.08 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 47 WSGLTFSVTFLISAIVSPLwgsLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLT-SGYIPNAMALVAS 125
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNL---LLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFeSGVFPGFILYLGM 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 126 QVPRERSGWALSTL-ATAQISGVIGGPLMGGFIADHV-----GLRPVFFITAMLLVVSFMVTLFLIKEGV---------- 189
Cdd:cd17327 122 WYKREEQAKRIAFFyAAAGLGSIFGGLLAYGVFKILGvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPskawflteee 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 190 ----------RPTLKKSERLSGKAVFASLPYPALVISLFFTTLvIQLCNGSISPILALFIKSMAPDSNNIAFLSGLIASV 259
Cdd:cd17327 202 kelaverlraNQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFC-SQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGAL 280
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 992389604 260 PGVSALISAPRLGKLGDR--IGTERILMATLICAVVLFFAMSWV 301
Cdd:cd17327 281 GAVSLLIAALLSDRFKKRglFAIFACVLALVGSIILLAAPNPPG 324
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
13-188 |
1.13e-03 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 40.81 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 13 FGCFFTGLAISQILPFLPLYISQLGvtshealsmWSGLTFSVTFLISAIVSP--LWGSLADRKGRKLMLLRASLGMAIAI 90
Cdd:PRK12382 223 LGLALQGVGFAVIGTFVSLYFASKG---------WAMAGFTLTAFGGAFVLMrvLFGWMPDRFGGVKVAIVSLLVETVGL 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 91 LLQAFATNVWQLFLLRGIMGLTSGYI-PNAMALVASQVPRERSGWALSTLATAQ-ISGVIGGPLMGgFIADHVGLRPVFF 168
Cdd:PRK12382 294 LLLWLAPTAWVALAGAALTGAGCSLIfPALGVEVVKRVPSQVRGTALGGYAAFQdIAYGVSGPLAG-MLATSFGYPSVFL 372
|
170 180
....*....|....*....|
gi 992389604 169 ITAMLLVVSFMVTLFLIKEG 188
Cdd:PRK12382 373 AGAISAVLGIIVTILSFRRG 392
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
8-184 |
1.61e-03 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 40.28 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 8 LISVWFGCFF---TGLAISQILPFLPLYISQLGVTSHEAlsmwsGLTFSVTFLISAIVSPLWGSLADRKG-RKLMLLRAS 83
Cdd:cd17385 200 IPSVLLLCLSivsGSVSLGFLDPTLSPHLRQFKLSPGQV-----GLMFLILAGSYAISAPLWGWLSDKKKiPKWLMVIGS 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 84 LGMAIAILLQA------FATNVWQLFLLRGIMGLTSG--YIPNAMALVASQV----PRERSGWAL-STLATAQIS-GVIG 149
Cdd:cd17385 275 IITGVGFLLLGpapllpIKSELWMVIIGLVLLGLSLGaaLVPTFPELLNCAReygfPDNLSTYGLvSGLFNAAFSlGAFI 354
|
170 180 190
....*....|....*....|....*....|....*.
gi 992389604 150 GPLMGGFIADHVGLR-PVFFITAMLLVVSFMVTLFL 184
Cdd:cd17385 355 GPTLGGFLLERLGFEwAATIQAGLAFVVGILMSIYY 390
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
44-136 |
2.29e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 39.83 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 44 LSMWS-GLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSGYIPNAMAL 122
Cdd:cd17372 31 LSAWQvALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLASW 110
|
90
....*....|....
gi 992389604 123 VASQVPRERSGWAL 136
Cdd:cd17372 111 YLEFLPAKSRGTWM 124
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
16-184 |
2.37e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.90 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 16 FFTGLAISQILPFLPLYISQLGVTSHEALsmwsGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAF 95
Cdd:cd17329 210 FLISLIYFQLESTLPVYVVEILGLGESLL----GLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAF 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 96 ATNVWQLFLLRGIMGL-TSGYIPNAMALVASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHVGLRPVFFITAMLL 174
Cdd:cd17329 286 ANTLAVLILAMIVLTLgEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALG 365
|
170
....*....|
gi 992389604 175 VVSFMVTLFL 184
Cdd:cd17329 366 LIAAALLLGL 375
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
67-185 |
2.45e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 40.10 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 67 GSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSGYI-PNAMALVASQVPRERS-GWALSTLATAQI 144
Cdd:PRK14995 62 GALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIvPATLAGIRATFTEEKQrNMALGVWAAVGS 141
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 992389604 145 SGVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLI 185
Cdd:PRK14995 142 GGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYV 182
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
52-319 |
2.65e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 39.62 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 52 FSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSG--YIPnAMALVASQVPR 129
Cdd:PRK10473 44 FSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGccYVV-AFAILRDTLDD 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 130 ERSGWALSTlataqISGVIG-----GPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFLIKEgVRPTLKKSERLSGKAV 204
Cdd:PRK10473 123 RRRAKVLSL-----LNGITCiipvlAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKE-TRPARAPAASSKPREN 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 205 FASLPYPALVISLFFTTLVIQ--LCNGSISPIlaLFIKSMAPDSNNIAFLSGLIASVPGVSALISAPRLGKLGdrigtER 282
Cdd:PRK10473 197 SESLLNRFFLSRLVITTLSVTviLTFVNTSPV--LLMEQMGFSRGEYAIIMALTAGVSMTVSFSTPFALGIFK-----PR 269
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 992389604 283 ILMAT---LICAVVLFFAMSWVTTPFQLGVLRFLLGFADG 319
Cdd:PRK10473 270 TLMLTsqvLFLAAGITLALSPSHAVSLFGITLICAGFSVG 309
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
48-162 |
3.10e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 39.96 E-value: 3.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 48 SGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGL-TSGYIPNAMALVASQ 126
Cdd:TIGR01299 204 KGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFgIGGAIPIVFSYFAEF 283
|
90 100 110
....*....|....*....|....*....|....*.
gi 992389604 127 VPRERSGWALSTLATAQISGVIGGPLMGGFIADHVG 162
Cdd:TIGR01299 284 LAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYG 319
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
217-401 |
3.10e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.46 E-value: 3.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 217 LFFTTLVIQLCNGSISPILALFIKSMapdsNNIAFLSGLIASVPGVSALISAPRLGKLGDRIGTERILMATLICAVVLFF 296
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKL----GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 297 AMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLLVKYSSDQItGRIFGYNQSFMYLGNVAGPLMGATVSAMAGFRWVFIAT 376
Cdd:cd17478 77 LLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRR-GLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILL 155
|
170 180
....*....|....*....|....*
gi 992389604 377 AIIVMINICQLALVLRQRRNIRKRA 401
Cdd:cd17478 156 IIPGLAVALLLLRLRPLKKPEAKKA 180
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
25-186 |
3.97e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 39.22 E-value: 3.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 25 ILPFLPLYISQlgvtshealSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFL 104
Cdd:cd17383 18 IVPIIPDYLNE---------DIAIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 105 LRGIMGLTSGYIPNA-MALVASQVPRERSGWALSTLATAQIS-GVIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTL 182
Cdd:cd17383 89 ARSLQGVGSAFADTAgLAMIADRFTEEAERSKALGIALAFISfGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLL 168
|
....
gi 992389604 183 FLIK 186
Cdd:cd17383 169 LVMK 172
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
254-382 |
4.28e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 39.15 E-value: 4.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 254 GLIASVPGVSALISAPRLGKLGDRIGTERILMATLI-CAVVLF---FAMSWVTTPFQLGVLRFLLGFADGAMLPAVQTLL 329
Cdd:cd17345 41 GLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLIlSAIINIligFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTM 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 330 VKYSSDQITGRIFG-YNQSFmylgNVAGPLMGATVSAMAGF------RWVFIATAIIVMI 382
Cdd:cd17345 121 VHWFSKKERGTWTSiWNISH----NVGGGLVGPLAGLGLAIfgdgwwRGAFIFPAIIAII 176
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
41-184 |
4.35e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 38.79 E-value: 4.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 41 HEALSMWSGLTFSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLTSGYIPNAM 120
Cdd:cd17360 30 VVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTV 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 992389604 121 ALVASQVPRERSGWALSTLATAQISG--VIGGPLMGGFIADHVGLRPVFFITAMLLVVSFMVTLFL 184
Cdd:cd17360 110 PLYIAEAAPPRIRGRLVTINVLFITGgqFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIGLLFL 175
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
9-187 |
4.60e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 39.10 E-value: 4.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 9 ISVWFGCFFTGLAISQILPFLPLYISQLGVTSHEALSMWSGLTfSVTFLISAIVSPLWGSLADRKGRKLMLLRASLGMAI 88
Cdd:cd17358 5 FVANLGSFSFGIAVGWSSPALPSLMSDNSLSLPLTVAQFSWFG-SLLTLGALIGALLSGKLADRIGRKRTLLISAIPCIL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 89 AILLQAFATNVWQLFLLRGIMGLTSGyipnAMALV-----ASQVPRERSGWALSTLATAQISGVIGGPLMGGFIADHvgl 163
Cdd:cd17358 84 GWLLIAFAKDVWMLYLGRFLAGFGGG----AASVVvpvyiAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLPWR--- 156
|
170 180
....*....|....*....|....
gi 992389604 164 rpVFFITAMLLVVSFMVTLFLIKE 187
Cdd:cd17358 157 --TLALIGAIPPVVFLILLFFIPE 178
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
38-128 |
4.75e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 38.94 E-value: 4.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 38 VTSHEALSMWSGLTFSVTFLISAIVsplWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGLT-SGYI 116
Cdd:cd17446 28 VCNHRALRQLAQSIYMAGVLVGAIV---FGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMAlSGIV 104
|
90
....*....|..
gi 992389604 117 PNAMALVASQVP 128
Cdd:cd17446 105 LNSVSLNVEWMP 116
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| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
67-224 |
9.84e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 38.02 E-value: 9.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 67 GSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFLLRGIMGL-TSGYIPNAMALVASQVPRERSGWALSTLATAQIS 145
Cdd:PRK11551 71 GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVgLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPF 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992389604 146 GVIGGPLMGGFIADHVGLRPVFFI--TAMLLVVSFMVTlfLIKEGVRPTLKKSERLSGKAVFASLPYP-------ALVIS 216
Cdd:PRK11551 151 GGALASVIGVLAAGDAAWRHIFYVggVGPLLLVPLLMR--WLPESRAFAQAAGAGKQRAPVLRALFGEgratatlLLWIS 228
|
....*...
gi 992389604 217 LFFTTLVI 224
Cdd:PRK11551 229 YFFTLIVL 236
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