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Conserved domains on  [gi|981322349|ref|WP_059538920|]
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MULTISPECIES: bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR [Burkholderia]

Protein Classification

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase( domain architecture ID 10012271)

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA

Gene Ontology:  GO:0003723|GO:0004845|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05205 PRK05205
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;
1-158 1.30e-78

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;


:

Pssm-ID: 235365  Cd Length: 176  Bit Score: 231.17  E-value: 1.30e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349   1 MSTIDADALYRVLLDQIRDAYGTAfAEPGGPRLAGIHSGGAWLAERLARDLGAPG-----FGVVNVALHRDDYAKKGLHS 75
Cdd:PRK05205   4 KEILDAEALRRALTRIAHEIIERN-KGLDNLVLVGIKTRGVWLAERLAERLEQLEgvdvpVGELDITLYRDDLTKKGLHP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349  76 QASPTSLPFEVDGARIVLVDDVLYTGRTVRAALNELFDYGRPAAVELAVLADRGGRELPVAARFAGGTLDVPADATLVLA 155
Cdd:PRK05205  83 QVKPTDIPFDIEGKRVILVDDVLYTGRTIRAALDALFDYGRPARVQLAVLVDRGHRELPIRADYVGKNIPTSRDERVVVR 162


                 ...
gi 981322349 156 RDE 158
Cdd:PRK05205 163 LAE 165
 
Name Accession Description Interval E-value
PRK05205 PRK05205
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;
1-158 1.30e-78

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;


Pssm-ID: 235365  Cd Length: 176  Bit Score: 231.17  E-value: 1.30e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349   1 MSTIDADALYRVLLDQIRDAYGTAfAEPGGPRLAGIHSGGAWLAERLARDLGAPG-----FGVVNVALHRDDYAKKGLHS 75
Cdd:PRK05205   4 KEILDAEALRRALTRIAHEIIERN-KGLDNLVLVGIKTRGVWLAERLAERLEQLEgvdvpVGELDITLYRDDLTKKGLHP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349  76 QASPTSLPFEVDGARIVLVDDVLYTGRTVRAALNELFDYGRPAAVELAVLADRGGRELPVAARFAGGTLDVPADATLVLA 155
Cdd:PRK05205  83 QVKPTDIPFDIEGKRVILVDDVLYTGRTIRAALDALFDYGRPARVQLAVLVDRGHRELPIRADYVGKNIPTSRDERVVVR 162


                 ...
gi 981322349 156 RDE 158
Cdd:PRK05205 163 LAE 165
PyrR COG2065
Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide ...
 33-149 6.62e-48

Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441668  Cd Length: 178  Bit Score: 153.29  E-value: 6.62e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349  33 LAGIHSGGAWLAERLARDL-----GAPGFGVVNVALHRDDYAKKGLHSQASPTSLPFEVDGARIVLVDDVLYTGRTVRAA 107
Cdd:COG2065   35 LVGIQTRGVPLAERLAERIeeiegVKVPVGSLDITLYRDDLRRRPPRPVVNETEIPFDIDGKTVVLVDDVLYTGRTVRAA 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 981322349 108 LNELFDYGRPAAVELAVLADRGGRELPVAARFAGGTLDVPAD 149
Cdd:COG2065  115 LDALMDFGRPAKIQLAVLVDRGHRELPIRADYVGKNVPTSRS 156
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 11-131 1.11e-12

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 61.64  E-value: 1.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349  11 RVLLDQIRDAYGTAFAepggprLAGIHSGGAWLAERLARDLGAPgFGVVNValHRDDYAKKGLHSQASPTSLPFEVDGAR 90
Cdd:cd06223    3 RLLAEEIREDLLEPDV------VVGILRGGLPLAAALARALGLP-LAFIRK--ERKGPGRTPSEPYGLELPLGGDVKGKR 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 981322349  91 IVLVDDVLYTGRTVRAALNELFDYGrPAAVELAVLADRGGR 131
Cdd:cd06223   74 VLLVDDVIATGGTLLAAIELLKEAG-AKVVGVAVLLDKPEG 113
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 33-135 3.62e-12

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 60.46  E-value: 3.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349   33 LAGIHSGGAWLAERLARDLGAPgFGVVNVALHRDDyakkgLHSQASPTSLPFEVDGARIVLVDDVLYTGRTVRAALNELF 112
Cdd:pfam00156  33 VVGILRGGLPFAGILARRLDVP-LAFVRKVSYNPD-----TSEVMKTSSALPDLKGKTVLIVDDILDTGGTLLKVLELLK 106

                          90       100
                  ....*....|....*....|...
gi 981322349  113 DYGrPAAVELAVLADRGGRELPV 135
Cdd:pfam00156 107 NVG-PKEVKIAVLIDKPAGTEPK 128
 
Name Accession Description Interval E-value
PRK05205 PRK05205
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;
1-158 1.30e-78

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;


Pssm-ID: 235365  Cd Length: 176  Bit Score: 231.17  E-value: 1.30e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349   1 MSTIDADALYRVLLDQIRDAYGTAfAEPGGPRLAGIHSGGAWLAERLARDLGAPG-----FGVVNVALHRDDYAKKGLHS 75
Cdd:PRK05205   4 KEILDAEALRRALTRIAHEIIERN-KGLDNLVLVGIKTRGVWLAERLAERLEQLEgvdvpVGELDITLYRDDLTKKGLHP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349  76 QASPTSLPFEVDGARIVLVDDVLYTGRTVRAALNELFDYGRPAAVELAVLADRGGRELPVAARFAGGTLDVPADATLVLA 155
Cdd:PRK05205  83 QVKPTDIPFDIEGKRVILVDDVLYTGRTIRAALDALFDYGRPARVQLAVLVDRGHRELPIRADYVGKNIPTSRDERVVVR 162


                 ...
gi 981322349 156 RDE 158
Cdd:PRK05205 163 LAE 165
PyrR COG2065
Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide ...
 33-149 6.62e-48

Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441668  Cd Length: 178  Bit Score: 153.29  E-value: 6.62e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349  33 LAGIHSGGAWLAERLARDL-----GAPGFGVVNVALHRDDYAKKGLHSQASPTSLPFEVDGARIVLVDDVLYTGRTVRAA 107
Cdd:COG2065   35 LVGIQTRGVPLAERLAERIeeiegVKVPVGSLDITLYRDDLRRRPPRPVVNETEIPFDIDGKTVVLVDDVLYTGRTVRAA 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 981322349 108 LNELFDYGRPAAVELAVLADRGGRELPVAARFAGGTLDVPAD 149
Cdd:COG2065  115 LDALMDFGRPAKIQLAVLVDRGHRELPIRADYVGKNVPTSRS 156
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 11-131 1.11e-12

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 61.64  E-value: 1.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349  11 RVLLDQIRDAYGTAFAepggprLAGIHSGGAWLAERLARDLGAPgFGVVNValHRDDYAKKGLHSQASPTSLPFEVDGAR 90
Cdd:cd06223    3 RLLAEEIREDLLEPDV------VVGILRGGLPLAAALARALGLP-LAFIRK--ERKGPGRTPSEPYGLELPLGGDVKGKR 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 981322349  91 IVLVDDVLYTGRTVRAALNELFDYGrPAAVELAVLADRGGR 131
Cdd:cd06223   74 VLLVDDVIATGGTLLAAIELLKEAG-AKVVGVAVLLDKPEG 113
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 33-135 3.62e-12

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 60.46  E-value: 3.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349   33 LAGIHSGGAWLAERLARDLGAPgFGVVNVALHRDDyakkgLHSQASPTSLPFEVDGARIVLVDDVLYTGRTVRAALNELF 112
Cdd:pfam00156  33 VVGILRGGLPFAGILARRLDVP-LAFVRKVSYNPD-----TSEVMKTSSALPDLKGKTVLIVDDILDTGGTLLKVLELLK 106

                          90       100
                  ....*....|....*....|...
gi 981322349  113 DYGrPAAVELAVLADRGGRELPV 135
Cdd:pfam00156 107 NVG-PKEVKIAVLIDKPAGTEPK 128
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 39-125 1.55e-07

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 48.30  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349  39 GGAWLAERLARDLGAPGFGVVNVAlHRDDYAKKGLHSQASPTsLPFEVDGARIVLVDDVLYTGRTVRAALNELFDYGrPA 118
Cdd:COG2236   41 GGLVPARILADALGVPDLASIRVS-SYTGTAKRLEEPVVKGP-LDEDLAGKRVLIVDDVADTGRTLEAVRDLLKEAG-PA 117


                 ....*..
gi 981322349 119 AVELAVL 125
Cdd:COG2236  118 EVRTAVL 124
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 85-147 4.52e-06

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 44.63  E-value: 4.52e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 981322349  85 EVDGARIVLVDDVLYTGRTVRAALNELFDYGrPAAVELAVLADR-GGRELPVAARFAGgtLDVP 147
Cdd:COG0634   88 DIEGRDVLIVEDIIDTGLTLSYLLELLKSRG-PASVKIATLLDKpERRKVDVPADYVG--FEIP 148
ComFC COG1040
DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General ...
 41-126 6.12e-05

DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General function prediction only];


Pssm-ID: 440662 [Multi-domain]  Cd Length: 196  Bit Score: 41.35  E-value: 6.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349  41 AWLAERLARDLGAPgfgVVNVALHRddyaKKGLHSQASPTSL--------------PFEVDGARIVLVDDVLYTGRTVRA 106
Cdd:COG1040  101 ELLARALARALGIP---VLPDLLRR----VRATPSQAGLSRAerrrnlrgafavrpPARLAGKHVLLVDDVLTTGATLAE 173

                         90       100
                 ....*....|....*....|
gi 981322349 107 ALNELFDYGrPAAVELAVLA 126
Cdd:COG1040  174 AARALKAAG-AARVDVLVLA 192
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 35-135 9.58e-05

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 41.01  E-value: 9.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981322349  35 GIHSGGAWLAERLARDLGApGFGVVnvalhrddYAKKGLHSQASPTSLPFE-----VDGARIVLVDDVLYTGRTVRAALN 109
Cdd:PRK02277  91 GIAKSGVPLATLVADELGK-DLAIY--------HPKKWDHGEGEKKTGSFSrnfasVEGKRCVIVDDVITSGTTMKETIE 161

                         90       100       110
                 ....*....|....*....|....*....|.
gi 981322349 110 ELFDYG-RPAAVelAVLAD-RGGREL---PV 135
Cdd:PRK02277 162 YLKEHGgKPVAV--VVLIDkSGIDEIdgvPV 190
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 88-109 9.87e-03

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 35.05  E-value: 9.87e-03
                         10        20
                 ....*....|....*....|..
gi 981322349  88 GARIVLVDDVLYTGRTVRAALN 109
Cdd:COG0503  112 GDRVLIVDDLLATGGTAKAAIK 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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