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Conserved domains on  [gi|970270339|ref|WP_058652610|]
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MULTISPECIES: MFS transporter [Enterobacter cloacae complex]

Protein Classification

MDR family MFS transporter( domain architecture ID 13023665)

MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26758938|26098515|27052334|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 13-397 3.52e-63

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 207.46  E-value: 3.52e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  13 VLLGSQFVFNIGFYAVVPFLAIFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLL 92
Cdd:cd17329    3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  93 AFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEakgkrsRAEWFALFAVCGELGAVLGPVMGALLTGLGFRQVA 172
Cdd:cd17329   83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPEN------RTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 173 LAGAGIFIVALVVLFFSLPAAHHSTKPLKILP----WWTTFRQPRFVAFIIAYSSWLLSYNQLYLALPVEIQRAGGN-EK 247
Cdd:cd17329  157 LAAAVLFLLAALVLLFLLPETRPKRRAAEKTEilrgYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLgES 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 248 DLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVALFAAteppegwlrLLPSASLVTLLTLGQMLLV 327
Cdd:cd17329  237 LLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANT---------LAVLILAMIVLTLGEMLVF 307

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 328 PSAKDLIPRFAEESTLGAHYGALSTAGGIAVLVGNLGLGSLLDKALvpsteAIYPWLLLAVFPLCSAVAL 397
Cdd:cd17329  308 PAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG-----PGLPWLILAALGLIAAALL 372
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 13-397 3.52e-63

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 207.46  E-value: 3.52e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  13 VLLGSQFVFNIGFYAVVPFLAIFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLL 92
Cdd:cd17329    3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  93 AFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEakgkrsRAEWFALFAVCGELGAVLGPVMGALLTGLGFRQVA 172
Cdd:cd17329   83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPEN------RTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 173 LAGAGIFIVALVVLFFSLPAAHHSTKPLKILP----WWTTFRQPRFVAFIIAYSSWLLSYNQLYLALPVEIQRAGGN-EK 247
Cdd:cd17329  157 LAAAVLFLLAALVLLFLLPETRPKRRAAEKTEilrgYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLgES 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 248 DLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVALFAAteppegwlrLLPSASLVTLLTLGQMLLV 327
Cdd:cd17329  237 LLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANT---------LAVLILAMIVLTLGEMLVF 307

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 328 PSAKDLIPRFAEESTLGAHYGALSTAGGIAVLVGNLGLGSLLDKALvpsteAIYPWLLLAVFPLCSAVAL 397
Cdd:cd17329  308 PAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG-----PGLPWLILAALGLIAAALL 372
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
23-273 3.29e-26

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 108.99  E-value: 3.29e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  23 IGFYAVVPFLAIFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVI 102
Cdd:PRK11646  24 LGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPWLLW 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 103 LGACLTGVGGALFSPSIEALLAKAGTQSEakgkrsRAEWFALFAVCGELGAVLGPVMGALLTGLGFRQVALAGAGIFIVA 182
Cdd:PRK11646 104 LSCILSGLGGTLFDPPRTALVIKLIRPHQ------RGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 183 LVVLFFSLPAAHHSTKPLKILPWWT-TFRQPRFVAFIIAYSSWLLSYNQLYLALPVEIQRAGGNEKDLGPLFMLASVLII 261
Cdd:PRK11646 178 AAFNAWLLPAYKLSTVRTPVREGMTrVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPSAVKWMYAIEACLSL 257

                        250
                 ....*....|..
gi 970270339 262 VLQLPLARFARK 273
Cdd:PRK11646 258 TLLYPIARWSEK 269
MFS_1 pfam07690
Major Facilitator Superfamily;
14-361 2.72e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.02  E-value: 2.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339   14 LLGSQFVFNIGFYAVVPFLAIFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLLA 93
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339   94 FGQSLWPVILGACLTGVGGALFSPSIEALLAkagtqsEAKGKRSRAEWFALFAVCGELGAVLGPVMGALLTG-LGFRQVA 172
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIA------DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  173 LAGAGIFIVALVVLFFSLPAAHHSTKPLKILPW------WTTFRQPRFVAFIIAYSSWLLSYNQLYLALPVEIQRAGGNE 246
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARlslivaWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  247 KDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVALFAATEPPegwlrlLPSASLVTLLTLGQMLL 326
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSS------LWLLLALLLLGFGFGLV 308

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 970270339  327 VPSAKDLIPRFAEESTLGAHYGALSTAGGIAVLVG 361
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-357 4.67e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.50  E-value: 4.67e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  13 VLLGSQFVFNIGFYAVVPFLAiFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLL 92
Cdd:COG2814   14 ALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  93 AFGQSLWPVILGACLTGVGGALFSPSIEALLAkagtqsEAKGKRSRAEWFALFAVCGELGAVLGPVMGALLTG-LGFRQV 171
Cdd:COG2814   93 ALAPSLWLLLAARFLQGLGAGALFPAALALIA------DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADlFGWRWV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 172 ALAGAGIFIVALVVLFFSLPAAHHSTKPLKILPWWTTFRQPRFVAFIIAYSSWLLSYNQLYLALPVEIQR-AGGNEKDLG 250
Cdd:COG2814  167 FLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAG 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 251 PLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVALFAAteppegwlrLLPSASLVTLLTLGQMLLVPSA 330
Cdd:COG2814  247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS---------LWLLLLALFLLGFGFGLLFPLL 317

                        330       340
                 ....*....|....*....|....*..
gi 970270339 331 KDLIPRFAEESTLGAHYGALSTAGGIA 357
Cdd:COG2814  318 QALVAELAPPEARGRASGLYNSAFFLG 344
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 66-301 5.19e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 41.99  E-value: 5.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339   66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLakagTQSEAKGKRSRAewFALF 145
Cdd:TIGR00710  61 GPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALV----RDIYPGEELSRI--YSIL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  146 AVCGELGAVLGPVMGA-LLTGLGFRQVALAGAGIFIVALVVLFFSLPAAHHSTKPLKILPWWTTF----RQPRFVAFIIA 220
Cdd:TIGR00710 135 MPVLALAPAVAPLLGGyILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEARIQISTYFETFllllKSKMFWGYALI 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  221 YSSWLLSYNQLYLALP-VEIQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLsaaFASVALFAA 299
Cdd:TIGR00710 215 YGASFGGFFAFFSGAPfVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILF---AVSAVLLEI 291


                  ..
gi 970270339  300 TE 301
Cdd:TIGR00710 292 TA 293
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 13-397 3.52e-63

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 207.46  E-value: 3.52e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  13 VLLGSQFVFNIGFYAVVPFLAIFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLL 92
Cdd:cd17329    3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  93 AFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEakgkrsRAEWFALFAVCGELGAVLGPVMGALLTGLGFRQVA 172
Cdd:cd17329   83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPEN------RTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 173 LAGAGIFIVALVVLFFSLPAAHHSTKPLKILP----WWTTFRQPRFVAFIIAYSSWLLSYNQLYLALPVEIQRAGGN-EK 247
Cdd:cd17329  157 LAAAVLFLLAALVLLFLLPETRPKRRAAEKTEilrgYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLgES 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 248 DLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVALFAAteppegwlrLLPSASLVTLLTLGQMLLV 327
Cdd:cd17329  237 LLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANT---------LAVLILAMIVLTLGEMLVF 307

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 328 PSAKDLIPRFAEESTLGAHYGALSTAGGIAVLVGNLGLGSLLDKALvpsteAIYPWLLLAVFPLCSAVAL 397
Cdd:cd17329  308 PAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG-----PGLPWLILAALGLIAAALL 372
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
23-273 3.29e-26

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 108.99  E-value: 3.29e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  23 IGFYAVVPFLAIFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVI 102
Cdd:PRK11646  24 LGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPWLLW 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 103 LGACLTGVGGALFSPSIEALLAKAGTQSEakgkrsRAEWFALFAVCGELGAVLGPVMGALLTGLGFRQVALAGAGIFIVA 182
Cdd:PRK11646 104 LSCILSGLGGTLFDPPRTALVIKLIRPHQ------RGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 183 LVVLFFSLPAAHHSTKPLKILPWWT-TFRQPRFVAFIIAYSSWLLSYNQLYLALPVEIQRAGGNEKDLGPLFMLASVLII 261
Cdd:PRK11646 178 AAFNAWLLPAYKLSTVRTPVREGMTrVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPSAVKWMYAIEACLSL 257

                        250
                 ....*....|..
gi 970270339 262 VLQLPLARFARK 273
Cdd:PRK11646 258 TLLYPIARWSEK 269
MFS_1 pfam07690
Major Facilitator Superfamily;
14-361 2.72e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.02  E-value: 2.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339   14 LLGSQFVFNIGFYAVVPFLAIFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLLA 93
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339   94 FGQSLWPVILGACLTGVGGALFSPSIEALLAkagtqsEAKGKRSRAEWFALFAVCGELGAVLGPVMGALLTG-LGFRQVA 172
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIA------DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  173 LAGAGIFIVALVVLFFSLPAAHHSTKPLKILPW------WTTFRQPRFVAFIIAYSSWLLSYNQLYLALPVEIQRAGGNE 246
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARlslivaWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  247 KDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVALFAATEPPegwlrlLPSASLVTLLTLGQMLL 326
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSS------LWLLLALLLLGFGFGLV 308

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 970270339  327 VPSAKDLIPRFAEESTLGAHYGALSTAGGIAVLVG 361
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-357 4.67e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.50  E-value: 4.67e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  13 VLLGSQFVFNIGFYAVVPFLAiFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLL 92
Cdd:COG2814   14 ALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  93 AFGQSLWPVILGACLTGVGGALFSPSIEALLAkagtqsEAKGKRSRAEWFALFAVCGELGAVLGPVMGALLTG-LGFRQV 171
Cdd:COG2814   93 ALAPSLWLLLAARFLQGLGAGALFPAALALIA------DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADlFGWRWV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 172 ALAGAGIFIVALVVLFFSLPAAHHSTKPLKILPWWTTFRQPRFVAFIIAYSSWLLSYNQLYLALPVEIQR-AGGNEKDLG 250
Cdd:COG2814  167 FLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAG 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 251 PLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVALFAAteppegwlrLLPSASLVTLLTLGQMLLVPSA 330
Cdd:COG2814  247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS---------LWLLLLALFLLGFGFGLLFPLL 317

                        330       340
                 ....*....|....*....|....*..
gi 970270339 331 KDLIPRFAEESTLGAHYGALSTAGGIA 357
Cdd:COG2814  318 QALVAELAPPEARGRASGLYNSAFFLG 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 19-400 2.30e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 91.87  E-value: 2.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  19 FVFNIGFYAVVPFLAIFLRDdMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSL 98
Cdd:cd17325    6 FLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  99 WPVILGACLTGVGGALFSPSIEALLAKAGTqseakgKRSRAEWFALFAVCGELGAVLGPVMGALLTG-LGFRQVALAGAG 177
Cdd:cd17325   85 WQLLLARFLQGLASAAVWPAAMALIADIAP------PEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 178 IFIVALVVLFFSLPAAHHSTK------PLKILPWWTTFRQPRFVAFIIAYSSWLLSYNQLYLALPVEIQRAGG-NEKDLG 250
Cdd:cd17325  159 LALLALVLALLLLPEPRPPPNkravsaARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 251 PLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVALFAAteppegwlrLLPSASLVTLLTLGQMLLVPSA 330
Cdd:cd17325  239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS---------FWLLLLLLALLGLGLGLVFPAT 309

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 331 KDLIPRFAEESTLGAHYGALSTAGGIAVLVGNLGLGSLLDKALVPsteaiYPWLLLAVFPLCSAVALSVI 400
Cdd:cd17325  310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA-----TPFLAAAALLLLAAVLFLLL 374
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
12-406 2.52e-16

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 79.92  E-value: 2.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  12 PVLLGSQFVFNIGFYAVV--PFLAIFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGY 89
Cdd:COG2223    5 RVLLLATLAFFLAFGVWYlwSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  90 LLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTqseakgKRSRAEWFALFAVCGELGAVLG-PVMGALLTGLGF 168
Cdd:COG2223   85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFP------PDRRGLALGLAAGGGNLGAAVAaFLAPLLIAAFGW 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 169 RQVALAGAGIFIVALVVLFF---SLPAAHHSTKPLKILPWWTTFRQPRFVAFIIAYSSWLLSYNQLYLALPVEIQRAGGN 245
Cdd:COG2223  159 RNAFLILGILLLVVAVLAWLflrDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 246 EK-DLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVALFaatepPEGWLRLLPSASLVTLLTLGQM 324
Cdd:COG2223  239 SAaTAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA-----LGSLWLFLVLFLLLGLALGGGN 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 325 LLVPSakdLIPRFAEESTLGAHYGALSTAGGIAVLVGNLGLGSLLDKALVPSTeaiyPWLLLAVFPLCSAVALSVICRPL 404
Cdd:COG2223  314 GAVFA---LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTA----AFLVFAVLALVALVLTLLLYRRP 386


                 ..
gi 970270339 405 RR 406
Cdd:COG2223  387 RR 388
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 13-188 2.73e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 79.54  E-value: 2.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  13 VLLGSQFVFNIGFYAVVPFLAIFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLL 92
Cdd:cd17325  203 ALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  93 AFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEakgkrsRAEWFALFAVCGELGAVLGP-VMGALLTGLGFRQV 171
Cdd:cd17325  283 PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG------RGTAMGLFNTAFSLGMVLGPlLGGFLYDAFGFATP 356

                        170
                 ....*....|....*..
gi 970270339 172 ALAGAGIFIVALVVLFF 188
Cdd:cd17325  357 FLAAAALLLLAAVLFLL 373
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 66-397 2.40e-14

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 73.82  E-value: 2.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSiEALLAKAGTQSEakgkrsRAEWFALF 145
Cdd:cd17388   59 GALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVA-AAYIADVTPPEQ------RARNFGLL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 146 AVCGELGAVLGPVMGALLTGLGFRQVALAGAGIFIVALVVLFFSLPAAHHSTK-PLKILPWWTTFRQPRFVAFIIAYSSW 224
Cdd:cd17388  132 GAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERrRAFRWRRANPFGSLRWLTGFPGLLGL 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 225 LLSYNQLYLALPV--------EIQRAGGNEKDLGPLFMLASVLIIVLQLPLARF-ARKVGAVRILPVGFLLLSAAFASVA 295
Cdd:cd17388  212 LAVFFLIQLIGQVpattwvlfTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPiAKRLGEKRAILLGLAADALGFLLLA 291

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 296 LfaatePPEGWLrLLPSASLVTLLTLGQmllvPSAKDLIPRFAEESTLGAHYGALSTAGGIAVLVGNLGLGSLLdkALVP 375
Cdd:cd17388  292 F-----ATQGWM-VFPILILLALGGIAG----PALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIF--AASP 359

                        330       340
                 ....*....|....*....|..
gi 970270339 376 STEAIYPWLLLAVFPLCSAVAL 397
Cdd:cd17388  360 ATWPGLAWIIGAALYLICLVLA 381
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 63-397 9.73e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 72.07  E-value: 9.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAkagtqsEAKGKRSRAEWF 142
Cdd:cd06174   49 PLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIA------DLFPERERGRAL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 143 ALFAVCGELGAVLGPVMGALL---TGLGFRQVALAGAGIFIVALVVLFFSLPAAHHSTKPLKILPWWTT--------FRQ 211
Cdd:cd06174  123 GLLQAFGSVGGILGPLLGGILassLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSvlkllkrvLKN 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 212 PRFVAFIIAYSSWLLSYNQLYLALPVEIQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAF 291
Cdd:cd06174  203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMAL 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 292 ASVALFAATEPPEGWLrllpsasLVTLLTLGQMLLVPSAKDLIPRFAEESTLGAHYGALSTAGGIAVLVGNLGLGSLLDK 371
Cdd:cd06174  283 GLALLLLAPSLLLLLL-------LLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355

                        330       340
                 ....*....|....*....|....*.
gi 970270339 372 ALVPSteaiYPWLLLAVFPLCSAVAL 397
Cdd:cd06174  356 TFGLT----GAFLVLAVLLLLAAILL 377
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 66-370 8.60e-12

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 66.06  E-value: 8.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPsIEALLAKAGTQSEakgkrsRAEWFALF 145
Cdd:cd17330   55 GRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADITDEEE------RAKAFGII 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 146 AVCGELGAVLGPVMGALL-TGLGFRQVALAGAGIFIVALVVLFFSLPaahhstkplkilpwwtTFRQPRFVAFIIAyssw 224
Cdd:cd17330  128 SAAFGLGFILGPALGGFLsTPYGYALPFLVAAALALLNLVLVLFFLP----------------PLRRLLLVYFLIA---- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 225 lLSYNQLYLALPV-EIQRAGGNEKDLGPLFMLASVLIIVLQLPLAR-FARKVGAVRILPVGFLLLSAAFASVALFAATep 302
Cdd:cd17330  188 -LAFAGLESVFSLfLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPrLAKRLGERKLLRLGLLLAIIGLLLLPFASSV-- 264

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 970270339 303 peGWLrllpsASLVTLLTLGQMLLVPSAKDLIPRFAEESTLGAHYGALSTAGGIAVLVGNLGLGSLLD 370
Cdd:cd17330  265 --PLL-----VLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYS 325
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 63-397 3.16e-11

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 64.52  E-value: 3.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRF-GAKSVILSGCIVRVAGYLLLAFGQ-SLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEAKgkRSRAe 140
Cdd:cd17346   58 IIGGWLADKVlGARRTVFIGGILMALGYLLLALSPfSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDPR--RDSG- 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 141 wFALFAVCGELGAVLGP-VMGALLTGLGFRQV-ALAGAGIFIVALVVLFFSLPAAHHStkplkilpwwttfRQPRFVAFI 218
Cdd:cd17346  135 -FSIFYMGINLGAFLAPlLCGTLGDNYGYHYGfGLAAVGMLLGLLIFLLGRKKLLERK-------------KMLAIIILF 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 219 IAYSSWLLSYNQLYLALPV----EIQRAGGNEKD-------LGPLF-MLASVLIIVLQLPLARFARKVGAVRILPVGFLL 286
Cdd:cd17346  201 LFAVVFWAIYEQAGTSLALfadeNVDRLLGGFTIppswfqsLNPLFiILLAPILAALWTKLGKRGKDPSIPTKFALGLLL 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 287 LSAAFASVALFAATEPPEGWLRLLPSASLVTLLTLGQMLLVPSAKDLIPRFAEES----TLGAHYGALSTAGGIAVLVGn 362
Cdd:cd17346  281 LGLSFLLMVLAASFAGGSGKVSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAKfagfMMGLWFLASALGNILAGYLA- 359

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 970270339 363 lGLGSLLDKALVPSTEAIYPWLLLAVFPLCSAVAL 397
Cdd:cd17346  360 -GFYAQPKDPLASALVYTDYFGLIGVIALVAGIIL 393
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 66-297 3.40e-11

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 64.11  E-value: 3.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDR-FGAKSVILSGCIVRVAGYLLLAFGQSLWPVIL-GACLTGVGGALFSpsieALLAKAGTQSEAKGKRSRAEWFA 143
Cdd:cd17471   53 GRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVLLLvGVVLLSLGAAAFP----QLFALAREYADRSSGRDATLFNS 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 144 LFAVCGELGAVLGPVMGA-LLTGLGFRQVALAGAGIFIVALVVLFFSLPAAH-HSTKPLKILPWWTTFRQPRFVAFIIAY 221
Cdd:cd17471  129 VLRAAFSLAWVIGPPLAFlLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKpPAQKATPASSLVKAPVNRRLLLLFAAF 208

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 970270339 222 SSwLLSYNQLYL-ALPVEI-QRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVALF 297
Cdd:cd17471  209 TL-LFAANSMYIiAMPLYVtNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALA 285
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
61-406 6.21e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 63.35  E-value: 6.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  61 MFIVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEakgkrsRAE 140
Cdd:COG2271   61 GQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKE------RGR 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 141 WFALFAVCGELGAVLGP-VMGALLTGLGFRQVALAGAGIFIVALVVlffslpaahhstkplkilpwwttfrqpRFVAFII 219
Cdd:COG2271  135 ALGIFNAGGPLGGALAPpLLGWLLAAFGWRAAFLILGLPGLLLALL---------------------------RFWLLAL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 220 AYSSWLLSYNQLYLALPVEIQRAGG-NEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPvgfLLLSAAFASVALFA 298
Cdd:COG2271  188 AYFLVYFALYGFLTWLPTYLVEVRGlSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV---LAIGLLLAALALLL 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 299 ATEPPEGWLRLLPSASLVTLLTLGQMLLVPSAKDLIPRFAeestLGAHYGALSTAGGIAVLVGNLGLGSLLDkalvpSTE 378
Cdd:COG2271  265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA----RGTASGLVNTFGFLGGALGPLLVGYLLD-----ATG 335

                        330       340
                 ....*....|....*....|....*...
gi 970270339 379 AIYPWLLLAVFPLCSAVALSVICRPLRR 406
Cdd:COG2271  336 YQAAFLLLAALALLAALLALLLLRETRK 363
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 63-371 7.95e-11

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 62.95  E-value: 7.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRFGA-KSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEakgkRSRAew 141
Cdd:cd17370   52 LFSGYLSDRTGKrKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSG----RGKA-- 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 142 FALFAVCGELGAVLGPVMGALL---TGLGFRQVALAGAGIFIVALVVLFFSLPAAHHSTKPLKILPWWTTFRQPR-FVAF 217
Cdd:cd17370  126 FGLHRALDTLGAVLGPLLAALLlylLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKaFWLY 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 218 IIAYS-SWLLSYNQLYLALpvEIQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLsaaFASVAL 296
Cdd:cd17370  206 LLAVAlFALGNFSFAFLIL--RAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSL---ALAYLG 280

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 970270339 297 FAATEPPEGWLRLLPSASLVTLLTLGQMllvpsaKDLIPRFAEESTLGAHYGALSTAGGIAVLVGNLGLGSLLDK 371
Cdd:cd17370  281 FALGSSLWLLLLGFILWGLYMGAQESIE------RAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDL 349
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 60-361 1.96e-10

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 61.81  E-value: 1.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  60 GMFIVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLakagTQSEAKGKRSRA 139
Cdd:cd17321   46 ALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALI----AATFPGERRGRA 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 140 ewFALFAVCGELGAVLGPVM-GALLTGLGFRqvalagaGIFIVALVVLFFSLPAAhhstkplkilpwwttfrqPRFVAFI 218
Cdd:cd17321  122 --LGLWGAVVGIGAALGPLLgGLLLELFGWR-------WIFLINVPIGLVALLLA------------------RTFSGAV 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 219 IAYSSWLLSYNQLYLALPVEIQRAGG-NEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFasvALF 297
Cdd:cd17321  175 LAAFLLGAALGGLLFLLPLYLQGVLGySPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGL---LLL 251

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 970270339 298 AATEPPEGWLRLLPSaslVTLLTLGQMLLVPSAKDLIPRFAEESTLGAHYGALSTAGGIAVLVG 361
Cdd:cd17321  252 ALLGADSSVWLLLPG---LVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 61-361 2.29e-10

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 61.82  E-value: 2.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  61 MFIVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAkagtQSEAKGKRSRAe 140
Cdd:cd17474   50 LMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIG----DLFEGGERAKA- 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 141 wFALFAVCGELGAVLGPVMGALLTGLGFRQVALAGAGIFIVALVVLFFSLPAAHHSTKPLKILPWWTTFR-QPRFVAFII 219
Cdd:cd17474  125 -MGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKaLRGRGLLTF 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 220 AYSSWLLSY----NQLYLALPVEiQRAGGNEKDLGPLFMLASVLIIVLQLPLARF-ARKVGAVRILPVGFLLLSAAFASV 294
Cdd:cd17474  204 LVSAFLYFFlyfaFLTYLPFLLE-LLYGISPIIIGLLFAGWSVLLALGSLFVGRLlKKRFGARRILVIGLLLYALSLLLL 282

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 970270339 295 ALFaatepPEGWLRLLPsaslVTLLTLGQMLLVPSAKDLIPRFAEESTLGAHYGALSTAGGIAVLVG 361
Cdd:cd17474  283 GFV-----PSLALLLIA----IVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 66-298 4.79e-10

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 60.69  E-value: 4.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGvGGALFSPSIeALLAKAgTQSEakgKRSRAewfalF 145
Cdd:cd17472   53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAISSVVM-ALLADL-TREE---NRTKA-----M 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 146 AVCG-------ELGAVLGPVMGALltgLGFRQVALAGAGIFIVALVVLFFSLPaaHHSTKPLKILPWWTTFRQ----PRF 214
Cdd:cd17472  122 ALIGasigiafAISMVLGPLLAAH---LGVSGLFLITAILSLVSLLILLFFVP--DPPKIVQISEKEKKKLKKllknKRL 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 215 VAFIIAYSSWLLSYNQLYLALPVEIQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVR-ILPVGFLLLSAAFAS 293
Cdd:cd17472  197 LRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKqVFVSSILLIAVGFLL 276


                 ....*
gi 970270339 294 VALFA 298
Cdd:cd17472  277 LLFAA 281
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
61-302 9.06e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 59.87  E-value: 9.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  61 MFIVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAgtqseakGKRSRAE 140
Cdd:COG0738   59 ASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL-------GPETAAS 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 141 WFALFAVCGELGAVLGPVMGALLTGLGF-----RQVALAGAGIFIVALVVLFFSLP--AAHHSTKPLKILPWWTTFRQPR 213
Cdd:COG0738  132 RLNLLHAFFSLGALLGPLLGGLLILLGLslswhLPYLILAVLLLLLALLFLRSKLPeiEEEEEEAAGSAASLKSLLKNPR 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 214 FVAFIIAY----------SSWLLSYNQLYLALPVEIqraggnekdLGPLFMLASVLIIVLQLPLARFARKVGAVRILpVG 283
Cdd:COG0738  212 LLLGGLAIflyvgaegaiGDWLPLYLKDVLGLSEAT---------AALGLSLFWGGMTIGRFLGGFLLKRFGPVRLL-RL 281

                        250
                 ....*....|....*....
gi 970270339 284 FLLLSAAFASVALFAATEP 302
Cdd:COG0738  282 SALLAAVGLLLALLAPGPW 300
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
18-370 7.27e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 57.22  E-value: 7.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  18 QFVFNIGFYAVVPFLAIFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAK-----SVILSGCIVRVAGYLLL 92
Cdd:COG2211   19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrPWILIGAIPLALSFVLL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  93 AF------GQSLWPVILGACLTGVGGALFSPSIEALLAkagTQSEAKGKRSRAewFALFAVCGELGAVLGPVMGALLTG- 165
Cdd:COG2211   99 FTapdlspTGKLIYALVTYLLLGLAYTLVNIPYSALGA---ELTPDYEERTRL--SSWRFAFAGLGGLLASVLPPPLVAa 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 166 ------LGFRQVALAGAGIFIVALVVLFFSLPAAHHSTKPLKILP--WWTTFRQPRFVAFIIAYSSWLLSYNQLYLALPV 237
Cdd:COG2211  174 fggdaaLGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKesLKALLKNRPFLLLLLAYLLFFLALALVAALLLY 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 238 EIQRAGGNEKDLGPLFMLASVLI-IVLQLPLARFARKVGAVRILPVGFLLLSAAFASVALFAATEPPEGWLrllpsasLV 316
Cdd:COG2211  254 YFKYVLGLSAALVGLLLALYFLAaLLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLV-------LA 326

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 970270339 317 TLLTLGQMLLVPSAKDLIPRFAEESTL-------GAHYGALSTAGGIAVLVGNLGLGSLLD 370
Cdd:COG2211  327 ALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLA 387
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 63-190 1.55e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 56.06  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEakgkrsRAEWF 142
Cdd:cd17489  245 PFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHR------RGAAN 318

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 970270339 143 ALFAVCGELGAVLGP-VMGALLTGLGFRQVALAGAGIFIVALVVLFFSL 190
Cdd:cd17489  319 GTFFIFFDLGIGLGGlLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 64-400 2.30e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 55.70  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  64 VGGALSDRFGAKSV-----ILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLakagTQSEAKGKRSR 138
Cdd:cd06173   53 FAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALL----PELVPKEQLVR 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 139 AEwfALFAVCGELGAVLGPVMGALLTGLGFRQVALAGAGIFIVALVVLFFSLPAAHHSTKPLKILPW-------WTTFRQ 211
Cdd:cd06173  129 AN--ALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLlrdlregLRYLRR 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 212 PRFVAFIIAYSSWLLSYNQLYLALPVEIQRA--GGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSA 289
Cdd:cd06173  207 SPLLRLLLLALALFALLGGALTVLLPLLAKEvlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 290 AFASVALFAAteppegwlrLLPSASLVTLLTLGQMLLVPSAKDLIPRFAEESTLGAHYGALSTAGGIAVLVGNLGLGSLL 369
Cdd:cd06173  287 ALLVLGLSPS---------LWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA 357

                        330       340       350
                 ....*....|....*....|....*....|.
gi 970270339 370 DKALVPSTeaiypWLLLAVFPLCSAVALSVI 400
Cdd:cd06173  358 DALGLSAV-----FLLAGALLLLAALLLLLL 383
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 64-296 2.70e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 55.27  E-value: 2.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  64 VGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEakgkrsRAEWFA 143
Cdd:cd17473   54 LAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEE------RAKMLG 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 144 LFAVCGELGAVLGPVMGALLTGLGFRQV-ALAGAGIFIVALVVLFFSLPAAHHSTKPLKILPWWTTFRQPR-FVAFIIAY 221
Cdd:cd17473  128 LQSAAMSLGGVVFLLLGGALAEIGWRAPfLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRvLPIYFLAF 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 222 SSWLLSYnqlylALPVEI-----QRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVAL 296
Cdd:cd17473  208 LAMLLFY-----VIPIQLpfllqERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL 282
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
13-193 4.05e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 54.91  E-value: 4.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  13 VLLGSQFVFNIGFYAVVPFLAIFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLL 92
Cdd:COG2211  232 LLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  93 AF--GQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEAK-GKRSRAEWFALFAVCGELGAVLGPVMGALLTGLGFR 169
Cdd:COG2211  312 FFlgPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGY 391

                        170       180
                 ....*....|....*....|....
gi 970270339 170 QVALAGAGIFIVALVVLFFSLPAA 193
Cdd:COG2211  392 VAGAAQSPSALTGIRLLFFLLPAV 415
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 66-191 8.95e-08

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 53.38  E-value: 8.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGvggaLFSPSIeaLLAKAgTQSEAKGKRSRAEWFALF 145
Cdd:cd17390   52 GSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLG----IFKHTQ--SLCKA-YLSDLVSEQERSRVLGRF 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 970270339 146 AVCGELGAVLGPVMGALLTGL--GFRQVALAGAGIFIVALVVLFFSLP 191
Cdd:cd17390  125 NAASSLGFILGPVVGGHLAETdgGFYYVALLCSAIFILNAGLVWFLLS 172
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
63-403 2.78e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 52.18  E-value: 2.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKagtqseaKGKRSRAEWF 142
Cdd:COG2807   71 PLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKR-------WFPDRVGLMT 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 143 ALFAVCGELGAVLGPVMGALLTGLGFRQVALAGAGI--FIVALVVLFFSLPAAHHSTKPLKILPWWTTFRQPRFVAFIIA 220
Cdd:COG2807  144 GLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALlaLLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLF 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 221 YSSWLLSYNQLYLALPVEIQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVALFAAT 300
Cdd:COG2807  224 FGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPG 303

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 301 EPPEGWlrllpsaslVTLLTLGQMLLVPSAKDLIP-RFAEESTLGAHYGALSTAGGIAVLVGNLGLGSLLDKALVPStea 379
Cdd:COG2807  304 SLPWLW---------AVLLGLGQGGLFPLALTLIGlRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWT--- 371

                        330       340
                 ....*....|....*....|....
gi 970270339 380 iYPWLLLAVFPLCSAVALSVICRP 403
Cdd:COG2807  372 -AALLLLAALAVLMLVAGLLAGRP 394
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 63-303 4.70e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 51.41  E-value: 4.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSeakgkrSRAEWF 142
Cdd:cd17477   49 PLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNE------NRGRVL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 143 ALFAVCGELGAVLGPVMGALLTGLGFrQVALAGAGIFIVALVVLFFSLPAAHHSTKPLKIlPWWTTFRQPRfVAFIIAYS 222
Cdd:cd17477  123 GLYSTVLGLGFALGPLLLALVGTAGA-LPFLIAAVLLLLALVPLLLTRRAAPEIEEAESI-SLRRLLRIAP-LALLGAFV 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 223 SWLLSyNQLYLALPVEIQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILpVGFLLLSAAFASVALFAATEP 302
Cdd:cd17477  200 AGFLE-GAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVL-LGCALLGALAALLLPLVPGLP 277


                 .
gi 970270339 303 P 303
Cdd:cd17477  278 L 278
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 17-188 5.30e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.06  E-value: 5.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  17 SQFVFNIGFYAVVPFLAIFLRDdMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQ 96
Cdd:cd17489    4 ANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  97 SLWPVILGACLTGVGGALFSPSIEALLAkagtqsEAKGKRSRAEWFALFAVCGELGAVLGPVMGALLTG-LGFRQVALAG 175
Cdd:cd17489   83 SVALLLVLRLIHGIGWGAFTTAAATLVA------DIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQhLGFAVLFIVA 156

                        170
                 ....*....|...
gi 970270339 176 AGIFIVALVVLFF 188
Cdd:cd17489  157 AVLALLALLLVFL 169
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 66-190 5.37e-07

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 51.11  E-value: 5.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKagtqSEAKGKRSRAewFALF 145
Cdd:cd17391  261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAK----ITPKEVAGRI--FGYN 334

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 970270339 146 AVCGELGAVLGPVMGALLTG-LGFRQVALAGAGIFIVALVVLFFSL 190
Cdd:cd17391  335 QSFQYLGNVAGPLLGSAIAAhFGYRAVFVVTALLVLLNAIWSFIFL 380
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
63-406 9.16e-07

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 50.58  E-value: 9.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRF-GAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLakaGTQ-SEAKGKRSRAe 140
Cdd:COG3104   73 LLGGWLADRLlGQRRAILLGGILMALGHFLLALPGGVTLFYLGLALIAVGNGLFKPNISSLV---GQLyDPGDPRRDAG- 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 141 wFALFAVCGELGAVLGP-VMGALLTGLGFRQV-ALAGAGIFIvALVVLFFSLPA-AHHSTKPLKILPWWTTFRQPRFVAF 217
Cdd:COG3104  149 -FTIFYMGINIGAFLAPlLCGYLGEKYGWHYGfGAAAIGMLI-GLIIFLLGRKYlGDIGLEPDNPLSKKERLIAVALGAL 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 218 I-IAYSSWLLSYNQL------------YLALPVEIQRAGGNEKD----LGPLFMLA------------------------ 256
Cdd:COG3104  227 LlVLVLAGLLSNANIanyllyviaiiaYFIFILRSKKLTKEERKrllaILILFLFSivfwalyeqagtslnlfadrnvdr 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 257 ----------------SVLIIVLQLPLARFARKVGAVRILP-------VGFLLLSAAFASVALFAATEPPEGwlrLLPSA 313
Cdd:COG3104  307 slfgfeippswfqslnPLFIIILAPVFAALWTKLGKRGKEPstptkfaLGLLLLGLGFLVMALAALLAGAGG---KVSPL 383

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 314 SLV---TLLTLGQMLLVPSAKDLIPRFAEES----TLGAHYGALSTAGGIAVLVGNLglgslldkaLVPSTEAIYpWLLL 386
Cdd:COG3104  384 WLVlayLLLTIGELCLSPVGLSMITKLAPARfagqMMGLWFLATALGNLLAGLLAGL---------YAVPGYTAY-FLLL 453

                        410       420
                 ....*....|....*....|
gi 970270339 387 AVFPLCSAVALSVICRPLRR 406
Cdd:COG3104  454 GGIALVAGVVLLLLSPKLRR 473
PRK12382 PRK12382
putative transporter; Provisional
 61-190 1.06e-06

putative transporter; Provisional


Pssm-ID: 183487 [Multi-domain]  Cd Length: 392  Bit Score: 50.44  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  61 MFIVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTqseakgKRSRAE 140
Cdd:PRK12382 265 MRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIFPALGVEVVKRVP------SQVRGT 338

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 970270339 141 WFALFAVCGELG-AVLGPVMGALLTGLGFRQVALAGAGIFIVALVVLFFSL 190
Cdd:PRK12382 339 ALGGYAAFQDIAyGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIVTILSF 389
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 14-188 1.11e-06

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 50.54  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  14 LLGSQFVFNIGFYAVVPFLAIFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLLA 93
Cdd:COG2270  243 FLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAY 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  94 FGQSLWP-VILGACLTGVGGALFSPSiEALLAKAGTQSEAkgkrsrAEWFALFAVCGELGAVLGPVMGALLTGL-GFRQV 171
Cdd:COG2270  323 FLTTALAfWILGLLIGLVMGGIQALS-RSLLARLIPPGRE------AEFFGLYALSGKAASFLGPLLFGLVTQLtGSQRL 395

                        170
                 ....*....|....*...
gi 970270339 172 ALAGAGI-FIVALVVLFF 188
Cdd:COG2270  396 GILSLIVfFVIGLVLLLR 413
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 66-396 1.38e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.86  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGtqseAKGKRSRAewFALF 145
Cdd:cd17324   55 GPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV----PPEKRGRA--IGLV 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 146 AVCGELGAVLGPVMGALLTG-LGFRQVALAGAGIFIVALVVLFFSLPA--AHHSTKPLKILPWWTTFRQPR----FVAFI 218
Cdd:cd17324  129 FSGLTLGLVLGRPLGGLLGQlLGWRAAFLAIAVLALLAALLLWRLLPSlpPKKPGSLGLLSSLLLLLRNPRlrlaYLITF 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 219 IAYSSWLLSYNqlYLAlPVEIQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAvRILPVGFLLLSAAFASVALFA 298
Cdd:cd17324  209 LLFGGFFALYT--YLA-PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGR-RALLIALLLLAAALLLLTLLG 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 299 ATeppegwlrLLPSASLVTLLTLGQMLLVPSAKDLIPRFAEEstlgahygALSTAGGIAVLVGNLG--LGSLLDKALVPS 376
Cdd:cd17324  285 PS--------PLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE--------ARGLASSLYLAAYNLGgaLGAALGGLVLDH 348

                        330       340
                 ....*....|....*....|
gi 970270339 377 TEAIYPWLLLAVFPLCSAVA 396
Cdd:cd17324  349 GGWAGVGWVGAALLLLALLL 368
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 63-401 4.37e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 48.34  E-value: 4.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAkagtqsEAKGKRSRAEWF 142
Cdd:cd17320   52 LLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVR------DLYSGAELAKIF 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 143 ALFAVCGELGAVLGPVMGALLTGLGFRQ---VALAGAGIFIVALVVLFF--SLPAAHHSTKPLKIL-PWWTTFRQPRFVA 216
Cdd:cd17320  126 SLLMMILAIAPALAPLLGGLLLLFFGWRaifVFLALLGLLLLLLVLLFLpeTLPEEKRKPLLSSLLrAYKRVLKNRRFLG 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 217 FIIAYSSWLLSYNQLYLALP-VEIQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVA 295
Cdd:cd17320  206 YALALGLSFAGLFAYLAAAPfIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLL 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 296 LFAATEPPEGWLRLLPsaslVTLLTLGQMLLVPSAKDLiprfaeesTLGAHYGALSTAGGIAVLVGNLGLGSLLdkALVP 375
Cdd:cd17320  286 LAALLGGLSLWPLVAP----LFLIFFGFGLIFPNATSL--------ALEPFPHVAGTASALLGFLQFLIGALAG--ALVG 351

                        330       340
                 ....*....|....*....|....*.
gi 970270339 376 STEAIYPWLLLAVFPLCSAVALSVIC 401
Cdd:cd17320  352 LLPNGTALPMGLLILVLGLLALLLLI 377
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 66-219 6.86e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 47.55  E-value: 6.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEAKGkrsraewFALF 145
Cdd:cd17478   52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLA-------MSIF 124

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 970270339 146 AVCGELGAVLGPV-MGALLTGLGFRQVALAGAGIFIVALVVLFFSLPAAHHSTKPLKILPWWTTFRQPRFVAFII 219
Cdd:cd17478  125 SVGGNLGFALGPLiAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLL 199
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 63-188 7.74e-06

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 47.60  E-value: 7.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEakgkrsRAEWF 142
Cdd:cd17331  262 LLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPED------TGTAL 335

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 970270339 143 ALFAVCGELGAVLGPVMGA-LLTGLGFRQVALAGAGIFIVALVVLFF 188
Cdd:cd17331  336 GLSHALFSLVRTVSPTIGGaLLQAYGFPSFGLLGAAINGLLTVYLLL 382
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 13-188 8.14e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 47.57  E-value: 8.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  13 VLLGSQFVFNIGFYAVVPFLAIFLRDDMLLSGGLIGLVLGLRTFSQQ-GMFIVGGALSDRFGAKSVILSGCIVRVAGYLL 91
Cdd:cd17474  202 TFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLAlGSLFVGRLLKKRFGARRILVIGLLLYALSLLL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  92 LAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAgTQSEAKGKRSRAEWFALFavcgeLGAVLGPV-MGALLTGLGFRQ 170
Cdd:cd17474  282 LGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTEL-APEEERGTASSLYNFVRF-----LGQAVGPLlFGLLLEIFGLSA 355

                        170
                 ....*....|....*...
gi 970270339 171 VALAGAGIFIVALVVLFF 188
Cdd:cd17474  356 PFLVGAAIALAAAVLLAL 373
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 63-296 8.69e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 47.11  E-value: 8.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAkagtqsEAKGKRSRAEWF 142
Cdd:COG0477   67 LLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIA------ELFPARERGRAL 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 143 ALFAVCGELGAVLGPVMGALLTG-LGFRQVALAGAGIFIVALVVLFFSLPAAHHSTKPLKILPWWTTFRQPRFVAFIIAY 221
Cdd:COG0477  141 GLWGAAIGLGLALGPLLGGLLVAaLGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLL 220

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 970270339 222 SSWLLSYNQLYLALPVEIQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVAL 296
Cdd:COG0477  221 LLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 66-307 1.27e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 46.88  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSpsieALLAKAGTQSEAKGKRSRAEWFALF 145
Cdd:cd17355   59 GRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTL----AAVAFATVAAWWFERRRGLALGILT 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 146 AVCGELGAVLGPVMGALLTGLGFRQ--VALAGAGIFIVALVVLFF-------SLPAAHHSTKPLKILPWWTTFRQPRFVA 216
Cdd:cd17355  135 AGGGLGSLVFLPLGAALIEAFGWRTalLVLALLALLVLVPVLLLLrrrpadlALRAYDDASPASPGSTLKEALRSASFWL 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 217 FIIAYSSWLLSYNQLYLALPVEIQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLlsAAFASVAL 296
Cdd:cd17355  215 LALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYAL--RALGLALL 292

                        250
                 ....*....|.
gi 970270339 297 FAATEPPEGWL 307
Cdd:cd17355  293 LLLPFPPLALL 303
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 13-187 3.40e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 45.62  E-value: 3.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  13 VLLGSQFVFNIGFYAVVPFLAIFLRDDMLLSGGLIGLVLGLRTFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLL 92
Cdd:cd17324  202 LAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLT 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  93 AFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEAKGkrsraewFALFAVCGELGAVLGPVMGAL-LTGLGFRQV 171
Cdd:cd17324  282 LLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLA-------SSLYLAAYNLGGALGAALGGLvLDHGGWAGV 354

                        170
                 ....*....|....*.
gi 970270339 172 ALAGAGIFIVALVVLF 187
Cdd:cd17324  355 GWVGAALLLLALLLAL 370
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 63-187 3.98e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 45.23  E-value: 3.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALF---SPSIEALLAKAGTQSEAKGkrsra 139
Cdd:cd17370  252 YPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQesiERAAVADLVPAELRGTAYG----- 326

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 970270339 140 eWFALFAVCGELGAvlGPVMGALLTGLGFRQVALAGAGIFIVALVVLF 187
Cdd:cd17370  327 -LFNTVVGIGWLLA--SLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 61-397 6.87e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 44.48  E-value: 6.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  61 MFIVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEakgkRSRAe 140
Cdd:cd17319   54 FQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARE----RGRA- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 141 wFALFAVCGELGAVLG-PVMGALLTGLGFRQVALAGAGIFIVALVVLFFSLpaahhstkplkilpwwttfrqPRFVAFII 219
Cdd:cd17319  129 -TGLFNSGAPLGAAIGpPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL---------------------RQVWGLAL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 220 AYSSWLLSYNQLYLALPVEIQRAGG-NEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVALFA 298
Cdd:cd17319  187 GYFGINYALYGLLTWLPTYLKQARGfSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAY 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 299 ATEPPegwlrlLPSASLVTLLTLGQMLLVPSAKDLIPRFAEESTLGAHYGALSTAGGIAVLVGNLGLGSLLDKALVPSTe 378
Cdd:cd17319  267 LTTSP------VVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTA- 339

                        330
                 ....*....|....*....
gi 970270339 379 aiyPWLLLAVFPLCSAVAL 397
Cdd:cd17319  340 ---AFLFLAAVALLAALLV 355
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 55-298 1.03e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 44.08  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  55 TFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILG-ACLTGVGGAL-FSPSIEALlakagTQSEA 132
Cdd:cd17352   48 LGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTyGVLGGLGLGLiYSPAIVIV-----GQYFE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 133 KgKRSRAEWFAlFAVCGELGAVLGPVMGALLTGLGFRQVALAGAGIFIVALVV-LFFSLpaahhstkplkilpwwttFRQ 211
Cdd:cd17352  123 K-KRGLATGIA-VAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCgLLLRL------------------LKD 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 212 PRFVAFIIAYSSWLLSYNQLYLALPVEIQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKvGAVRILPVGFLLLSAAF 291
Cdd:cd17352  183 PTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADK-PRIGRLYLYIFTLLILG 261


                 ....*..
gi 970270339 292 ASVALFA 298
Cdd:cd17352  262 LSLLAFP 268
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 66-300 1.07e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 44.10  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGtqseAKGKRSRAewFALF 145
Cdd:cd17503   52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIY----PPEKRGAA--MGLV 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 146 AVCGELGAVLGPVMGALLTGlgfrqvALAGAGIFIVALVVLFFSLPAAHhstkplkILPWWtTFRQPRFVAFIIAYSSWL 225
Cdd:cd17503  126 GLVILLAPAIGPTLGGWLTD------NLSWRWIFYINLPIGILALLLAP-------LLDLR-LFKDRNFTLGLLLSFLLG 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 970270339 226 LSYNQLYLALPVEIQRAGGNEKDLGPLFMLASVLIIVLQLPLA-RFARKVGAVRILPVGFLLLSAAFASVALFAAT 300
Cdd:cd17503  192 LGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVgRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPD 267
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 63-188 1.47e-04

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 43.72  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTqseaKGKRSRAEWF 142
Cdd:cd17358   59 LLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAP----KNVRGALGSL 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 970270339 143 ALFAVCgeLGAVLGPVMGALLTglgFRQVALAGAGIFIVALVVLFF 188
Cdd:cd17358  135 NQLLVN--IGILLGYVLGSFLP---WRTLALIGAIPPVVFLILLFF 175
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 63-318 2.38e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 42.99  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAkagtQSEAKGKRSRAewF 142
Cdd:cd17328   52 PIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIA----DLFPKEKRTRA--L 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 143 ALFAVCGELGAVLGPVMGALLTGLGFR-QVALAGAGIFIVALVVLFF-------SLPAAHHSTKPLKILPWWTT----FR 210
Cdd:cd17328  126 GVFYFAIPLGSGLGYVVGGLVAQATGGwRWAFRVTGVLGVLLAILLLlfvreppRGAAEGGVMAKSTATSFLADlkalAK 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 211 QPRFVAFIIAYSSWLLSYNQLYLALPVEIQRAGGNEKD--------LGPLFMLASVLIIVLQLPLA-RFARKVGAVRILP 281
Cdd:cd17328  206 NPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLssadvgliFGAITCIAGVLGVLLGGILAdRLRRKTPRADPLV 285

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 970270339 282 VGFLLLSAAFASVA--LFAATEPPEGWLRLLPSASLVTL 318
Cdd:cd17328  286 CAVGLLAAAPFLFLalVLALSNLLLAWVLLFLGEFLLSL 324
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 66-188 4.09e-04

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 42.21  E-value: 4.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGA-KSVILSGCIVRVAGYLLLA------FGQSLWPVILGACLTGVG-GALFSPSIEALLAKAGTQSEAKGKRS 137
Cdd:cd17385  257 GWLSDKKKIpKWLMVIGSIITGVGFLLLGpapllpIKSELWMVIIGLVLLGLSlGAALVPTFPELLNCAREYGFPDNLST 336

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 970270339 138 RAEWFALFAVCGELGAVLGPVM-GALLTGLGFRQVALAGAGI-FIVALVVLFF 188
Cdd:cd17385  337 YGLVSGLFNAAFSLGAFIGPTLgGFLLERLGFEWAATIQAGLaFVVGILMSIY 389
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 55-189 4.73e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 42.23  E-value: 4.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  55 TFSQQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALlakagtqSEAKG 134
Cdd:cd06179   42 SLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVA-------SELVP 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 970270339 135 KRSRAEWFALFAVCGELGAVLGPVMGALLT---GLGFRQVALAGAGIFIVALVVLFFS 189
Cdd:cd06179  115 NKYRGLVQGVVNLVASPGSALGPLIAGALVeanAAGWRWIFYINAIFNALALILLFFF 172
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 66-301 5.19e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 41.99  E-value: 5.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339   66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLakagTQSEAKGKRSRAewFALF 145
Cdd:TIGR00710  61 GPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALV----RDIYPGEELSRI--YSIL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  146 AVCGELGAVLGPVMGA-LLTGLGFRQVALAGAGIFIVALVVLFFSLPAAHHSTKPLKILPWWTTF----RQPRFVAFIIA 220
Cdd:TIGR00710 135 MPVLALAPAVAPLLGGyILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEARIQISTYFETFllllKSKMFWGYALI 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  221 YSSWLLSYNQLYLALP-VEIQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLsaaFASVALFAA 299
Cdd:TIGR00710 215 YGASFGGFFAFFSGAPfVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILF---AVSAVLLEI 291


                  ..
gi 970270339  300 TE 301
Cdd:TIGR00710 292 TA 293
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 63-191 6.90e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 41.57  E-value: 6.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339   63 IVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVG-GALFsPSIEALLakagtqSEAKGKRSRAEW 141
Cdd:TIGR00895  70 LFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGlGGLM-PNLNALV------SEYAPKRFRGTA 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 970270339  142 FALFAVCGELGAVLGPVMGA-LLTGLGFRQVALAGAGIFIVALVVLFFSLP 191
Cdd:TIGR00895 143 VGLMFCGYPIGAAVGGFLAGwLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 63-190 8.85e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 41.03  E-value: 8.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGgalfspsIEALLAKAGT-QSEAKGKRSRAEW 141
Cdd:cd17365   52 LLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG-------LGAAMPNAITlVSEYAPARRRSLA 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 970270339 142 FALFAVCGELGAVLGPVMGA-LLTGLGFRQVALAGAGIFIVALVVLFFSL 190
Cdd:cd17365  125 VTLMFCGYPLGAALGGFLAAaLIPAFGWRSVFLLGGVPPLILLPLLRGTL 174
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 17-367 1.26e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.71  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  17 SQFVFNIGFYAVVPFLAIFLRDDMLLSGGLIGL---VLGLRTFSQQGMFI-VGGALSDRFGAKSVILSGCIVRVAGYLLL 92
Cdd:cd17391    4 GNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELwsgLAFSSTFLVSAIFSpIWGRLADRYGRKPMLLRASLGMAIVIGLM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  93 AFGQSLWPVILGACLTGVggalFSPSIEALLAKAGTQSEakgkRSRAEW-FALFAVCGELGAVLGPVMGALLTGL-GFRQ 170
Cdd:cd17391   84 AFVTNVWQLLILRLLQGV----FSGYVPNATALIASQTP----KEKSGWaLGTLSTGVVAGTLIGPLLGGFLADLfGIRN 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 171 V-ALAGAGIFIVALVVLFF----SLPAAHHSTKPLKILPWWTTFRQPRFVAFIIAYSSWLLSYNQLYLaLPVEIQRAGGN 245
Cdd:cd17391  156 VfFITGGLLFLAFLLTLFFvkedFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPI-LTLYIRQLMGD 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 246 EKDL----GPLFMLASVLIIVLQLPLARFARKVGAVRILpVGFLLLSAAFASVALFAATEPPEGWLRLlpsaslvtLLTL 321
Cdd:cd17391  235 ASNLafisGLVFSATGVSSLLSAPRLGKLGDRIGHHRIL-LGALLASALLYIPQAFVQTPWQLGILRF--------LLGL 305

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 970270339 322 GQMLLVPSAKDLIPRFAEESTLGAHYGALSTAGGIAVLVGNLgLGS 367
Cdd:cd17391  306 ATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPL-LGS 350
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 60-189 1.88e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 40.25  E-value: 1.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  60 GMFIVG---GALSDRFGAKSVILSGCIVRVAGYLLLAF-GQSLWPVILGACLTGVGGALFSPSIEALLAkagtqsEAKGK 135
Cdd:cd17504  229 VMLIAGplaGRLIARVGPRRVLLIGLVISAVGLLLLALlHSSLWALVVALLLIGIGLGLAFASLPNIVV------ESVPP 302

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 970270339 136 RSRAEWFALFAVCGELGAVLGPVMGALL--------------TGLGFRQVALAGAGIFIVALVVLFFS 189
Cdd:cd17504  303 DRTGIATGMNTVLRTIGSAIGPAIAGAIlttytvsitsggvpTEGAYVLAFLIGAALALAALLLSLLI 370
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
66-190 2.19e-03

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 39.90  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSEAKGKRSRAEWFAlf 145
Cdd:PRK09874 279 GKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFR-- 356

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 970270339 146 avcgELGAVLGPVMGALLTG-LGFRQVALAGAGIFIVALVVLFFSL 190
Cdd:PRK09874 357 ----DIGNVTGPLMGAAISAnYGFRAVFLVTAGVVLFNAVYSWNSL 398
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 66-189 2.19e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 39.85  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAkagtqsEAKGKRSRAEWFALF 145
Cdd:cd17502   51 GKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIA------DLVPPRERGKYQGYI 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 970270339 146 AVCGELGAVLGPVMGALLT-GLGFRQV----------ALAGAGIFIVALVVLFFS 189
Cdd:cd17502  125 GAVFGIASVAGPLIGGAFTdHLSWRWCfyinlpigglALALLRTILLSSIFGFLF 179
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 66-296 4.66e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 38.79  E-value: 4.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIeALLAKAGTqseaKGKRSRAewFALF 145
Cdd:cd17389   85 GAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLST-AIVADVTS----PKKRSKG--MALI 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 146 AVCGELGAVLGPVMGALLT-------GLGFRQVALAGAGIFIVALVVLFFSLPAAHHSTkpLKILPWwttfrqprfvafi 218
Cdd:cd17389  158 GVAFSLGFIIGPMIGAYFAsftrslgEVFFSMPALFALVLALADLLFIFFFLPETLPSN--LRRLGL------------- 222

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 970270339 219 iAYSSWLLSYNQLYLALP-VEIQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFLLLSAAFASVAL 296
Cdd:cd17389  223 -VYFLYLFLFSGLEFTLTfLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPGKEKKAVLQGLILLIPAFLLIGW 300
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 66-285 4.75e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 38.72  E-value: 4.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIV-RVAGYLLLAF-GQSLWPVILGACLTGVGGALFSPSIEAL-LAKAGTQSEAKGK-RSRAEW 141
Cdd:cd17335   53 GALADRFGKRKALLLLSLLaAVLFFLSLFFvAQIFWLLLLLVILGAFFSAPVVPLVDSItLQYLGEERERYGKqRLWGSI 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339 142 -FALFAVcgelgaVLGPVMGALLTGLGFRQVALAGAGIFIVALVVLFFSLPAAHHSTKPLKILPWWTTFRQPRFVAFIIA 220
Cdd:cd17335  133 gFGIAAL------LVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLV 206

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 970270339 221 Y----SSWLLSYNQLYLALpveiQRAGGNEKDLGPLFMLASVLIIVLQLPLARFARKVGAVRILPVGFL 285
Cdd:cd17335  207 AflmgFGHGLIYSFLFWHL----QDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLL 271
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 63-187 5.20e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 38.68  E-value: 5.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  63 IVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSpSIEALLAkagtQSEAKGKRSRAEwf 142
Cdd:cd17471  253 LLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITA-GLGISYF----QDLMPGQPGLAT-- 325

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 970270339 143 ALFAVCGELGAVLG-PVMGALLTGLGFRQVALAGAGIFIVALVVLF 187
Cdd:cd17471  326 TLYSNASRIGSLLGgLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
PRK05122 PRK05122
major facilitator superfamily transporter; Provisional
 66-185 7.51e-03

major facilitator superfamily transporter; Provisional


Pssm-ID: 235348 [Multi-domain]  Cd Length: 399  Bit Score: 38.33  E-value: 7.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGTQSeakgkrSRAEWFALF 145
Cdd:PRK05122 270 GNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGFSLVFPALGVEAVKRVPPQ------NRGAALGAY 343

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 970270339 146 AVCGELG-AVLGPVMGALLTGLGFRQVALAGAGIFIVALVV 185
Cdd:PRK05122 344 SVFLDLSlGITGPLAGLVASWFGYPSIFLAAALAALLGLAL 384
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 68-190 7.56e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 38.36  E-value: 7.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  68 LSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGALFSPSIEALLAKAGtqseakGKRSRAEWFALFAV 147
Cdd:cd17329  259 LVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALA------PPDKRGSYMGFYAL 332

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 970270339 148 CGELGAVLGPVMGALLTGLGFRQVALAGAGIFIVALVVLFFSL 190
Cdd:cd17329  333 AWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
66-188 9.03e-03

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 37.98  E-value: 9.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970270339  66 GALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILGACLTGVGGAlFSPSIEALLAkagtqseAKGKRSRAEW-FAL 144
Cdd:PRK09874  75 GGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGG-FVPNANALIA-------TQVPRNKSGWaLGT 146

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 970270339 145 FAVCGELGAVLGPVMGALLT-GLGFRQVALAGAGIFIVALVVLFF 188
Cdd:PRK09874 147 LSTGGVSGALLGPLAGGLLAdSYGLRPVFFITASVLFLCFLVTLF 191
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 58-122 9.94e-03

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 37.76  E-value: 9.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 970270339  58 QQGMFIVGGALSDRFGAKSVILSGCIVRVAGYLLLAFGQSLWPVILG-ACLTGVGGAL-FSPSIEAL 122
Cdd:cd17423   51 QQLASPVGSALSTRYGARPVVMLGGLLSSLGFLLASFATSLLHLYLCiGLLSGLGWALvFAPTMATV 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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