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Conserved domains on  [gi|966404459|ref|WP_058447956|]
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IS66 family insertion sequence element accessory protein TnpB [Legionella feeleii]

Protein Classification

transposase( domain architecture ID 10529723)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0004803|GO:0003677|GO:0006313
PubMed:  30454069|11418571|20215432

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TnpB_IS66 pfam05717
IS66 Orf2 like protein; This protein is found in insertion sequences related to IS66. The ...
 12-97 3.27e-35

IS66 Orf2 like protein; This protein is found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition.


:

Pssm-ID: 461723  Cd Length: 96  Bit Score: 116.03  E-value: 3.27e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966404459   12 YCGITDMRKSINTLAILVKEVFGMELESGHLFLFRSRCGSKLKALYYEECSFTLWYRRLERGKFIFP-RNTQGHIELTKD 90
Cdd:pfam05717   1 ATGPTDMRKGIDGLAALVQEALGLDPFSGHLFVFRNRRRDRIKILYWDGDGFWLYYKRLERGRFVWPrRAGDGVVELTAA 80


                  ....*..
gi 966404459   91 HLNWLMA 97
Cdd:pfam05717  81 QLSWLLE 87
 
Name Accession Description Interval E-value
TnpB_IS66 pfam05717
IS66 Orf2 like protein; This protein is found in insertion sequences related to IS66. The ...
 12-97 3.27e-35

IS66 Orf2 like protein; This protein is found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition.


Pssm-ID: 461723  Cd Length: 96  Bit Score: 116.03  E-value: 3.27e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966404459   12 YCGITDMRKSINTLAILVKEVFGMELESGHLFLFRSRCGSKLKALYYEECSFTLWYRRLERGKFIFP-RNTQGHIELTKD 90
Cdd:pfam05717   1 ATGPTDMRKGIDGLAALVQEALGLDPFSGHLFVFRNRRRDRIKILYWDGDGFWLYYKRLERGRFVWPrRAGDGVVELTAA 80


                  ....*..
gi 966404459   91 HLNWLMA 97
Cdd:pfam05717  81 QLSWLLE 87
IS66_TnpB NF033819
IS66 family insertion sequence element accessory protein TnpB; The IS66 family insertion ...
 9-97 5.87e-35

IS66 family insertion sequence element accessory protein TnpB; The IS66 family insertion sequence element encodes a DDE transposase TnpC, and two accessory proteins, TnpA and TnpB. It has been assumed that the TnpA, TnpB, and TnpC proteins are produced independently in appropriate amounts and form a complex, which acts as a transposase to promote the transposition of an IS66 family element.


Pssm-ID: 411392  Cd Length: 90  Bit Score: 115.27  E-value: 5.87e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966404459   9 VHLYCGITDMRKSINTLAILVKEVFGMELESGHLFLFRSRCGSKLKALYYEECSFTLWYRRLERGKFIFPRNTQGHIELT 88
Cdd:NF033819   1 IYLATGPTDMRKGIDGLAALVQEVLGLDPFSGHLFVFRNRRRDRLKILYWDGSGFCLYYKRLEKGRFRWPRAADGVVALT 80


                 ....*....
gi 966404459  89 KDHLNWLMA 97
Cdd:NF033819  81 PAQLAWLLE 89
M28_like cd05662
M28 Zn-Peptidases; Peptidase family M28 (also called aminopeptidase Y family), uncharacterized ...
 51-112 1.30e-03

M28 Zn-Peptidases; Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions. This subfamily is composed of uncharacterized proteins that do not contain a protease-associated (PA) domain.


Pssm-ID: 349912 [Multi-domain]  Cd Length: 268  Bit Score: 36.68  E-value: 1.30e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966404459  51 SKLKALYYEECSFTLWYRR-LERGKFIFPRNTQGH-IELTKDHLNWLMASNKYTFHPGEDPVIY 112
Cdd:cd05662  166 PERNELYVEGASQFPQLTSiLENVKGTCIKALHPKdTDGSIGSIDWTRASDHYPFHKAKIPWLY 229
COG3436 COG3436
Transposase [Mobilome: prophages, transposons];
13-92 1.72e-03

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 442662 [Multi-domain]  Cd Length: 416  Bit Score: 36.55  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966404459  13 CGITDMRKsINTLAILVKEV-FGMELESGHLFLFRSRCGsKLKALYYEEcsFTLWY-----RRLERGkfIFPRNTQGHIE 86
Cdd:COG3436   81 HEPTDMRK-IDGLAAIGEEVsEELDLDPGALFVFRNRRD-KYKCLYCDG--TGLVYapapaKRLEKG--LAGPGLLAHIL 154


                 ....*...
gi 966404459  87 LTK--DHL 92
Cdd:COG3436  155 VSKfvDHL 162
 
Name Accession Description Interval E-value
TnpB_IS66 pfam05717
IS66 Orf2 like protein; This protein is found in insertion sequences related to IS66. The ...
 12-97 3.27e-35

IS66 Orf2 like protein; This protein is found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition.


Pssm-ID: 461723  Cd Length: 96  Bit Score: 116.03  E-value: 3.27e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966404459   12 YCGITDMRKSINTLAILVKEVFGMELESGHLFLFRSRCGSKLKALYYEECSFTLWYRRLERGKFIFP-RNTQGHIELTKD 90
Cdd:pfam05717   1 ATGPTDMRKGIDGLAALVQEALGLDPFSGHLFVFRNRRRDRIKILYWDGDGFWLYYKRLERGRFVWPrRAGDGVVELTAA 80


                  ....*..
gi 966404459   91 HLNWLMA 97
Cdd:pfam05717  81 QLSWLLE 87
IS66_TnpB NF033819
IS66 family insertion sequence element accessory protein TnpB; The IS66 family insertion ...
 9-97 5.87e-35

IS66 family insertion sequence element accessory protein TnpB; The IS66 family insertion sequence element encodes a DDE transposase TnpC, and two accessory proteins, TnpA and TnpB. It has been assumed that the TnpA, TnpB, and TnpC proteins are produced independently in appropriate amounts and form a complex, which acts as a transposase to promote the transposition of an IS66 family element.


Pssm-ID: 411392  Cd Length: 90  Bit Score: 115.27  E-value: 5.87e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966404459   9 VHLYCGITDMRKSINTLAILVKEVFGMELESGHLFLFRSRCGSKLKALYYEECSFTLWYRRLERGKFIFPRNTQGHIELT 88
Cdd:NF033819   1 IYLATGPTDMRKGIDGLAALVQEVLGLDPFSGHLFVFRNRRRDRLKILYWDGSGFCLYYKRLEKGRFRWPRAADGVVALT 80


                 ....*....
gi 966404459  89 KDHLNWLMA 97
Cdd:NF033819  81 PAQLAWLLE 89
M28_like cd05662
M28 Zn-Peptidases; Peptidase family M28 (also called aminopeptidase Y family), uncharacterized ...
 51-112 1.30e-03

M28 Zn-Peptidases; Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions. This subfamily is composed of uncharacterized proteins that do not contain a protease-associated (PA) domain.


Pssm-ID: 349912 [Multi-domain]  Cd Length: 268  Bit Score: 36.68  E-value: 1.30e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966404459  51 SKLKALYYEECSFTLWYRR-LERGKFIFPRNTQGH-IELTKDHLNWLMASNKYTFHPGEDPVIY 112
Cdd:cd05662  166 PERNELYVEGASQFPQLTSiLENVKGTCIKALHPKdTDGSIGSIDWTRASDHYPFHKAKIPWLY 229
COG3436 COG3436
Transposase [Mobilome: prophages, transposons];
13-92 1.72e-03

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 442662 [Multi-domain]  Cd Length: 416  Bit Score: 36.55  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966404459  13 CGITDMRKsINTLAILVKEV-FGMELESGHLFLFRSRCGsKLKALYYEEcsFTLWY-----RRLERGkfIFPRNTQGHIE 86
Cdd:COG3436   81 HEPTDMRK-IDGLAAIGEEVsEELDLDPGALFVFRNRRD-KYKCLYCDG--TGLVYapapaKRLEKG--LAGPGLLAHIL 154


                 ....*...
gi 966404459  87 LTK--DHL 92
Cdd:COG3436  155 VSKfvDHL 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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