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Conserved domains on  [gi|960413363|ref|WP_058305310|]
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Lrp/AsnC family transcriptional regulator [Vitreoscilla massiliensis]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-143 2.71e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 162.64  E-value: 2.71e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960413363   4 IVLDKIDLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRYAALLSPAAIELGLQAFIRVTLnkAGGGR 83
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV--PPHRL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 960413363  84 EKFDEAVQGWQEILSCFALTGETDYMLHAFFVDMEHFSHFVLEVLLNQEGVQDARSSFVL 143
Cdd:COG1522   79 DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-143 2.71e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 162.64  E-value: 2.71e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960413363   4 IVLDKIDLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRYAALLSPAAIELGLQAFIRVTLnkAGGGR 83
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV--PPHRL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 960413363  84 EKFDEAVQGWQEILSCFALTGETDYMLHAFFVDMEHFSHFVLEVLLNQEGVQDARSSFVL 143
Cdd:COG1522   79 DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
6-157 2.36e-40

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 133.35  E-value: 2.36e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960413363   6 LDKIDLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRYAALLSPAAIELGLQAFIRVTLNK-AGGGRE 84
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRgAPDVFE 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 960413363  85 KFDEAVQGWQEILSCFALTGETDYMLHAFFVDMEHFSHFVLEVLLNQEGVQDARSSFVLREVKKTTALPLNHL 157
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRLVIKTR 164
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 6-112 2.08e-34

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 116.46  E-value: 2.08e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960413363     6 LDKIDLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRYAALLSPAAIELGLQAFIRVTLNKAgGGREK 85
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENP-DKLEE 79

                           90       100
                   ....*....|....*....|....*..
gi 960413363    86 FDEAVQGWQEILSCFALTGETDYMLHA 112
Cdd:smart00344  80 FLEKLEKLPEVEEVYLVTGDYDYLLKV 106
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
8-52 9.67e-18

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 72.08  E-value: 9.67e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 960413363    8 KIDLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVI 52
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 7-55 8.07e-10

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 52.30  E-value: 8.07e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 960413363   7 DKIDLKILQVLQENGrLTNVELSERVALSPSPCLRRLKQLEDAGVIQRY 55
Cdd:cd00090    6 DPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-143 2.71e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 162.64  E-value: 2.71e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960413363   4 IVLDKIDLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRYAALLSPAAIELGLQAFIRVTLnkAGGGR 83
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV--PPHRL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 960413363  84 EKFDEAVQGWQEILSCFALTGETDYMLHAFFVDMEHFSHFVLEVLLNQEGVQDARSSFVL 143
Cdd:COG1522   79 DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
6-157 2.36e-40

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 133.35  E-value: 2.36e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960413363   6 LDKIDLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRYAALLSPAAIELGLQAFIRVTLNK-AGGGRE 84
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRgAPDVFE 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 960413363  85 KFDEAVQGWQEILSCFALTGETDYMLHAFFVDMEHFSHFVLEVLLNQEGVQDARSSFVLREVKKTTALPLNHL 157
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRLVIKTR 164
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 6-112 2.08e-34

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 116.46  E-value: 2.08e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960413363     6 LDKIDLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRYAALLSPAAIELGLQAFIRVTLNKAgGGREK 85
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENP-DKLEE 79

                           90       100
                   ....*....|....*....|....*..
gi 960413363    86 FDEAVQGWQEILSCFALTGETDYMLHA 112
Cdd:smart00344  80 FLEKLEKLPEVEEVYLVTGDYDYLLKV 106
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
8-52 9.67e-18

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 72.08  E-value: 9.67e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 960413363    8 KIDLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVI 52
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 72-145 1.69e-17

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 72.17  E-value: 1.69e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 960413363   72 IRVTLnKAGGGREKFDEAVQGWQEILSCFALTGETDYMLHAFFVDMEHFSHFVLEVLLNQEGVQDARSSFVLRE 145
Cdd:pfam01037   1 VEVKL-EPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
7-47 1.19e-15

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 66.62  E-value: 1.19e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 960413363    7 DKIDLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLE 47
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 7-55 8.07e-10

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 52.30  E-value: 8.07e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 960413363   7 DKIDLKILQVLQENGrLTNVELSERVALSPSPCLRRLKQLEDAGVIQRY 55
Cdd:cd00090    6 DPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-93 2.07e-06

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 45.09  E-value: 2.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960413363   1 MQNIVLDKIDLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRYAALLSPAAIELGLQAFIRVTLNKAG 80
Cdd:PRK11179   2 MENYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAK 81

                         90
                 ....*....|....*....
gi 960413363  81 ------GGREKFDEAVQGW 93
Cdd:PRK11179  82 dypsalAKLESLDEVVEAY 100
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 12-77 5.21e-06

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 44.74  E-value: 5.21e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960413363  12 KILQVLQENGRLTNVELSERVALSPSpCLRR-LKQLEDAGVIQR---YAALLSPAAIELGLQAfiRVTLN 77
Cdd:COG1349    9 KILELLRERGRVSVEELAERLGVSEE-TIRRdLAELEEQGLLRRvhgGAVLVSSAAAEPPFAE--RETLN 75
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 6-55 7.40e-05

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 39.13  E-value: 7.40e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 960413363   6 LDKIDLKILQVLQEN-GRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRY 55
Cdd:COG2512   13 LLEDERRVLELLRENgGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKE 63
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
12-54 1.11e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 40.25  E-value: 1.11e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 960413363  12 KILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQR 54
Cdd:COG3398  101 RILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVER 143
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
10-55 1.67e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 38.73  E-value: 1.67e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 960413363    10 DLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRY 55
Cdd:smart00347  12 QFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRRE 57
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 11-55 6.63e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 35.99  E-value: 6.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 960413363   11 LKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRY 55
Cdd:pfam01047   6 FHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERS 50
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
10-54 7.13e-04

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 37.64  E-value: 7.13e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 960413363  10 DLKILQVLQENGR-LTNVELSERVALSPSPCLRRLKQLEDAGVIQR 54
Cdd:COG3355   29 DAEVYLILLENGEpLTVEELAEALDRSRSTVYRSLQKLLEAGLVER 74
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
11-55 1.27e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 36.55  E-value: 1.27e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 960413363  11 LKILQVLQEnGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRY 55
Cdd:COG1777   20 RRILALLSE-EPAYVSELARELGVSRQAVYKHLRKLEEAGLVESY 63
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
12-57 1.31e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 37.60  E-value: 1.31e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 960413363  12 KILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRYAA 57
Cdd:COG2345   17 RILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETE 62
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 4-52 3.72e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 34.05  E-value: 3.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 960413363    4 IVLDKIDLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVI 52
Cdd:pfam12840   6 ALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLV 54
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
12-55 6.21e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 33.72  E-value: 6.21e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 960413363    12 KILQVLqENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQRY 55
Cdd:smart00418   1 KILKLL-AEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESR 43
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
10-54 8.37e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 34.56  E-value: 8.37e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 960413363  10 DLKILQVLQENGRLTNVELSERVALSPSPCLRRLKQLEDAGVIQR 54
Cdd:COG1846   40 QFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVER 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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