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Conserved domains on  [gi|948140621|ref|WP_056798960|]
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MULTISPECIES: roadblock/LC7 domain-containing protein [Streptomyces]

Protein Classification

roadblock/LC7 domain-containing protein( domain architecture ID 10005177)

roadblock/LC7 domain-containing protein such as Trichoplax sp. H2 ragulator complex protein LAMTOR2

CATH:  3.30.450.30
PubMed:  11084347

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2018 COG2018
Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal ...
 5-125 1.02e-22

Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal transduction mechanisms];


:

Pssm-ID: 441621  Cd Length: 123  Bit Score: 86.83  E-value: 1.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948140621   5 AEVKDVLDELQRLRARVPLLTGALAASTDGLVVAQDTP--GIQAEGVAALTAAALGVSIRMTDATGRGGFRELLIRGADG 82
Cdd:COG2018    1 EQAEKLDWLLDDLVERVPGVRGAVLVSADGLLIASSLGldDDDAERLAAMAAGLLSLARRAARELGAGEVEQVVVEGERG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 948140621  83 YVATYAAGSSAVLTLLAEDRINVGRLHLEGRRAGARIGEVVDA 125
Cdd:COG2018   81 YLLVTAAGDGAVLAVLADPDADLGLVRYEMRRLAERLGELLTP 123
 
Name Accession Description Interval E-value
COG2018 COG2018
Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal ...
 5-125 1.02e-22

Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal transduction mechanisms];


Pssm-ID: 441621  Cd Length: 123  Bit Score: 86.83  E-value: 1.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948140621   5 AEVKDVLDELQRLRARVPLLTGALAASTDGLVVAQDTP--GIQAEGVAALTAAALGVSIRMTDATGRGGFRELLIRGADG 82
Cdd:COG2018    1 EQAEKLDWLLDDLVERVPGVRGAVLVSADGLLIASSLGldDDDAERLAAMAAGLLSLARRAARELGAGEVEQVVVEGERG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 948140621  83 YVATYAAGSSAVLTLLAEDRINVGRLHLEGRRAGARIGEVVDA 125
Cdd:COG2018   81 YLLVTAAGDGAVLAVLADPDADLGLVRYEMRRLAERLGELLTP 123
Robl_LC7 pfam03259
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 11-99 1.09e-13

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 397386  Cd Length: 91  Bit Score: 62.65  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948140621   11 LDELQRLRARVPLLTGALAASTDGLVVA-QDTPGIQAEGVAALTAAALGVSIRMTDATGRGGFRELLIRGADGYVATYAA 89
Cdd:pfam03259   2 DEELLDLLQRVPGVRGALVVSKDGLVIAsSTLDNDDADHLAALASGLLSAAKGAARDLGSGELRQLLIEGKKGELYLTPA 81

                          90
                  ....*....|
gi 948140621   90 GSSAVLTLLA 99
Cdd:pfam03259  82 GEGALLVVLA 91
Robl_LC7 smart00960
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 11-90 5.50e-10

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 214939  Cd Length: 88  Bit Score: 52.96  E-value: 5.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948140621    11 LDELQRLRARVPLLTGALAASTDGLVVAQDTPG-IQAEGVAALTAAALGVSIRMTDATGRGGFRELLIRGADGYVATYAA 89
Cdd:smart00960   1 IEELLDLLARVPGVRGALVVSRDGLLLASSGLSdDDAERLAALAAGLLSLAERAARELGEGELRQLRIEGEKGEVLITPA 80


                   .
gi 948140621    90 G 90
Cdd:smart00960  81 G 81
 
Name Accession Description Interval E-value
COG2018 COG2018
Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal ...
 5-125 1.02e-22

Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal transduction mechanisms];


Pssm-ID: 441621  Cd Length: 123  Bit Score: 86.83  E-value: 1.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948140621   5 AEVKDVLDELQRLRARVPLLTGALAASTDGLVVAQDTP--GIQAEGVAALTAAALGVSIRMTDATGRGGFRELLIRGADG 82
Cdd:COG2018    1 EQAEKLDWLLDDLVERVPGVRGAVLVSADGLLIASSLGldDDDAERLAAMAAGLLSLARRAARELGAGEVEQVVVEGERG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 948140621  83 YVATYAAGSSAVLTLLAEDRINVGRLHLEGRRAGARIGEVVDA 125
Cdd:COG2018   81 YLLVTAAGDGAVLAVLADPDADLGLVRYEMRRLAERLGELLTP 123
Robl_LC7 pfam03259
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 11-99 1.09e-13

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 397386  Cd Length: 91  Bit Score: 62.65  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948140621   11 LDELQRLRARVPLLTGALAASTDGLVVA-QDTPGIQAEGVAALTAAALGVSIRMTDATGRGGFRELLIRGADGYVATYAA 89
Cdd:pfam03259   2 DEELLDLLQRVPGVRGALVVSKDGLVIAsSTLDNDDADHLAALASGLLSAAKGAARDLGSGELRQLLIEGKKGELYLTPA 81

                          90
                  ....*....|
gi 948140621   90 GSSAVLTLLA 99
Cdd:pfam03259  82 GEGALLVVLA 91
Robl_LC7 smart00960
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 11-90 5.50e-10

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 214939  Cd Length: 88  Bit Score: 52.96  E-value: 5.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948140621    11 LDELQRLRARVPLLTGALAASTDGLVVAQDTPG-IQAEGVAALTAAALGVSIRMTDATGRGGFRELLIRGADGYVATYAA 89
Cdd:smart00960   1 IEELLDLLARVPGVRGALVVSRDGLLLASSGLSdDDAERLAALAAGLLSLAERAARELGEGELRQLRIEGEKGEVLITPA 80


                   .
gi 948140621    90 G 90
Cdd:smart00960  81 G 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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