|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
1-475 |
0e+00 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 797.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 1 MRLGLRIFLVYALFIGLTGYFVLNTVMKEIRPGVRQSTEETLVDTANLLAEILREDVKNGTLGQSHWPALLKAYGNRQPG 80
Cdd:PRK11100 1 MRIGLRLFLGYFLIVALAAYFVLRIFVQEVKPGVRQATEETLVDTANLLAELARDDLLSGRLADGRLAQAFAQLQQRPFR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 81 AVIWGLPKNQVNHRIYVTDAKGRVLLDSSGEAVGQDYSKWNDVYLTLRGEYGARSTRSDADDATSSVMHVGAPIRDNGQI 160
Cdd:PRK11100 81 ANIWGIRKTRVDYRVYVTDAQGIVLFDSEGRAVGQDYSRWNDVYLTLRGEYGARSTREDPADPESSVMYVAAPIRDGGRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 161 IGVVTVAKPNSSLQPYVDRTERRLLWYGAGLVTLGLLLGALLSWWLTAALRRLTAYAEAVSEGRRAELPHYRGGELKQLS 240
Cdd:PRK11100 161 IGVLSVGKPNSSMAPFIKRSERRILWAGALLLGIALLIGAGVVWWLNRSIRRLTRYADAVTEGKPVPLPKLGSSELRELA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 241 TAVEHMRTQLEGKAYVERYVHTLTHELKSPLAAIRGAAELLQGDMSREQQQRFVGNIDSESARLQQLIERLLNLAQVEQR 320
Cdd:PRK11100 241 QALESMRVKLEGKAYVEQYVQTLTHELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 321 QGLEEQSSIPLSALVEDVLKAQCARIEGAGLHVEQAIaADVKVFGEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHH 400
Cdd:PRK11100 321 QELEVLEPVALAALLEELVEAREAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGE 399
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 948124490 401 EVQVTLFNQAEAIPDYALPRLSERFYSLPRPASGRKSTGLGLNFVEEVMKLHGGTLQIGNVP-GGVQAVLHLHTVS 475
Cdd:PRK11100 400 QVALSVEDQGPGIPDYALPRIFERFYSLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPeGGVLATLTLPRHF 475
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
366-471 |
2.00e-50 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 167.25 E-value: 2.00e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 366 EPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLPRPASGRKSTGLGLNFV 445
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFV 80
|
90 100
....*....|....*....|....*.
gi 948124490 446 EEVMKLHGGTLQIGNVPGGVQAVLHL 471
Cdd:cd16945 81 QEVAQLHGGRITLRNRPDGVLAFLTL 106
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
238-464 |
5.32e-50 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 170.47 E-value: 5.32e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 238 QLSTAVEHMRTQLEGKayvERYVHTLTHELKSPLAAIRGAAELLQ--GDMSREQQQRFVGNIDSESARLQQLIERLLNLA 315
Cdd:COG2205 1 ELEEALEELEELERLK---SEFLANVSHELRTPLTSILGAAELLLdeEDLSPEERRELLEIIRESAERLLRLIEDLLDLS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 316 QVEQRQGLEEQSSIPLSALVEDVLKAQCARIEGAGLHVEQAIAAD-VKVFGEPFLLRQALGNLLDNALDFTPPGGTLRFS 394
Cdd:COG2205 78 RLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITIS 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 395 AQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLPRpASGRKSTGLGLNFVEEVMKLHGGTLQIGNVPGG 464
Cdd:COG2205 158 ARREGDGVRISVSDNGPGIPEEELERIFERFYRGDN-SRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGG 226
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
181-464 |
4.98e-49 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 172.81 E-value: 4.98e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 181 ERRLLWYGAGLVTLGLLLGALLSWWLTAALRRLTAYAEAVSEGRRAELPHYRGGELKQLSTAVEHMRTQLEgKAYVER-- 258
Cdd:COG5002 89 LLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELE-RLEQMRre 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 259 YVHTLTHELKSPLAAIRGAAELLQGDM--SREQQQRFVGNIDSESARLQQLIERLLNLAQVEQRQGLEEQSSIPLSALVE 336
Cdd:COG5002 168 FVANVSHELRTPLTSIRGYLELLLDGAadDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLE 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 337 DVLKAQCARIEGAGLHVE-QAIAADVKVFGEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPD 415
Cdd:COG5002 248 EVVEELRPLAEEKGIELElDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPE 327
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 948124490 416 YALPRLSERFYSLpRPASGRKS--TGLGLNFVEEVMKLHGGTLQIGNVPGG 464
Cdd:COG5002 328 EDLPRIFERFYRV-DKSRSRETggTGLGLAIVKHIVEAHGGRIWVESEPGK 377
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
178-464 |
1.37e-48 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 169.70 E-value: 1.37e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 178 DRTERRLLWYGAGLVTLGLLLGALLSWWLTAALRRLTAYAEAVSEGRRAELPHYRGGELKQLSTAVEHMRTQLEGKayvE 257
Cdd:COG0642 35 LLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAK---S 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 258 RYVHTLTHELKSPLAAIRGAAELLQGDMSrEQQQRFVGNIDSESARLQQLIERLLNLAQVEQRQGLEEQSSIPLSALVED 337
Cdd:COG0642 112 RFLANVSHELRTPLTAIRGYLELLLEELD-EEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 338 VLKAQCARIEGAGLHVEQAIAADV-KVFGEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDY 416
Cdd:COG0642 191 VVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPE 270
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 948124490 417 ALPRLSERFYSLpRPASGRKSTGLGLNFVEEVMKLHGGTLQIGNVPGG 464
Cdd:COG0642 271 DLERIFEPFFRT-DPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGK 317
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
263-471 |
2.75e-30 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 121.99 E-value: 2.75e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 263 LTHELKSPLAAIRGAAELLQGDMS------REQQQRFVGNIDSESARLQQLIERLLNLAQVEQRQgLEEQSsipLSALVE 336
Cdd:COG5000 208 IAHEIKNPLTPIQLSAERLRRKLAdkleedREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQ-LEPVD---LNELLR 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 337 DVLKAQCARIEGAGLHVEQAIAADV-KVFGEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPD 415
Cdd:COG5000 284 EVLALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPE 363
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 948124490 416 YALPRLSERFYSlprpaSGRKSTGLGLNFVEEVMKLHGGTLQIGNVPG-GVQAVLHL 471
Cdd:COG5000 364 EVLERIFEPFFT-----TKPKGTGLGLAIVKKIVEEHGGTIELESRPGgGTTFTIRL 415
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
265-463 |
4.36e-27 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 111.86 E-value: 4.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 265 HELKSPLAAIRGAAELLQGDMSREQQQRFVGNIDSESARLQQLIERLLNLAqveqRQGLEEQSSIPLSALVEDVLKAQCA 344
Cdd:COG3852 144 HEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFS----RPRPPEREPVNLHEVLERVLELLRA 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 345 RIeGAGLHVEQAIAADV-KVFGEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHhevQVTLFNQAEA----------- 412
Cdd:COG3852 220 EA-PKNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVER---QVTLGGLRPRlyvrievidng 295
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 948124490 413 --IPDYALPRLSERFYslprpaSGRKS-TGLGLNFVEEVMKLHGGTLQIGNVPG 463
Cdd:COG3852 296 pgIPEEILDRIFEPFF------TTKEKgTGLGLAIVQKIVEQHGGTIEVESEPG 343
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
2-457 |
5.57e-27 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 112.87 E-value: 5.57e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 2 RLGLRIFLVYALFIGLTGYFVLNTVMKEIrpgVRQSTEEtLVDTANLLAEILREDVKNgtlgQSHWPALLKAYGNrqpga 81
Cdd:TIGR01386 7 RLALLFAAVTALVFALSGFMLYSSLERHF---EERDREE-LQGKLEQVRRFLRDPADL----DEDIKRLQEKIDD----- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 82 viwgLPKNQVNHRIYVTDAKGRVLLDSSGEAVGQDYSKWNDVYLTLRgeygARSTRSDADDATSSVmhVGAPIRDNGQII 161
Cdd:TIGR01386 74 ----LLVGHSDLALSILNPDGRLLFERAQGAALVPAVAANDALLELD----QADAKMTHYRSILRS--VAALPGGKGRKP 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 162 GVVTVAKPNSSLQPYVDRTERRLLWygagLVTLGLLLGALLSWWLTAA----LRRLTAYAEAVSEGR-RAELPHYRG-GE 235
Cdd:TIGR01386 144 VQITVALDINAHTHLLDALRKWLIL----IAVLLVLLTALLGWWITRLglepLRRLSAVAARISPESlDQRLDPSRApAE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 236 LKQLSTAVEHMRTQLEGkAYV--ERYVHTLTHELKSPLAAIRGAAE-LLQGDMSREQQQRFV-GNIDsESARLQQLIERL 311
Cdd:TIGR01386 220 LRELAQSFNAMLGRLED-AFQrlSQFSADLAHELRTPLTNLLGQTQvALSQPRTGEEYREVLeSNLE-ELERLSRMVSDM 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 312 LNLAQVEQRQGLEEQSSIPLSALVEDVLKAQCARIEGAGLHVEqaIAADVKVFGEPFLLRQALGNLLDNALDFTPPGGTL 391
Cdd:TIGR01386 298 LFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIR--VEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTI 375
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 392 RFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYslpRPASGR----KSTGLGLNFVEEVMKLHGGTLQ 457
Cdd:TIGR01386 376 TVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFY---RVDPARsnsgEGTGLGLAIVRSIMEAHGGRAS 442
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
235-464 |
3.76e-26 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 111.03 E-value: 3.76e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 235 ELKQLSTAVEHMRTQLEGK-AYVERYVHTLTHELKSPLAAIRGAAELLQ---GDMSREQQQRFVGNIDSESARLQQLIER 310
Cdd:COG4251 260 ELEELEEELEERTAELERSnEELEQFAYVASHDLREPLRKISGFSQLLEedyGDKLDEEGREYLERIRDAAERMQALIDD 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 311 LLNLAQVEQRQglEEQSSIPLSALVEDVLKAQCARIEGAGLHVEqaIAADVKVFGEPFLLRQALGNLLDNALDFTPPG-- 388
Cdd:COG4251 340 LLAYSRVGRQE--LEFEPVDLNELLEEVLEDLEPRIEERGAEIE--VGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGep 415
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 389 GTLRFSAQVQHHEVQVTL------FNQAEAipdyalPRLSERFYSLPrPASGRKSTGLGLNFVEEVMKLHGGTLQIGNVP 462
Cdd:COG4251 416 PRIEIGAEREGGEWVFSVrdngigIDPEYA------EKIFEIFQRLH-SRDEYEGTGIGLAIVKKIVERHGGRIWVESEP 488
|
..
gi 948124490 463 GG 464
Cdd:COG4251 489 GE 490
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
265-470 |
2.21e-25 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 108.20 E-value: 2.21e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 265 HELKSPLAAIRGAAELLQGDMSREQ-QQRFVGNIDSESARLQQLIERLLNLAQVEQRQGLEEQSSIPLSALVEDVL---- 339
Cdd:PRK10337 246 HELRSPLAALKVQTEVAQLSDDDPQaRKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVmdiy 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 340 -KAQCARIEGAgLHVEqaiAADVKVFGEPFLLRQALGNLLDNALDFTPPGGTlrfsaqvqhheVQVTLFNQAEAIPDY-- 416
Cdd:PRK10337 326 hTAQQAGIDVR-LTLN---AHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSV-----------VDVTLNARNFTVRDNgp 390
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 948124490 417 -----ALPRLSERFYslpRPASGRKS-TGLGLNFVEEVMKLHGGTLQIGNVP-GGVQAVLH 470
Cdd:PRK10337 391 gvtpeALARIGERFY---RPPGQEATgSGLGLSIVRRIAKLHGMNVSFGNAPeGGFEAKVS 448
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
179-464 |
9.12e-24 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 102.18 E-value: 9.12e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 179 RTERRLLWYGAGLVTLGLLLGALLSWWLTAALRRLTAYAEAVSEGRRAELPHYRGGELKQLSTAVEHMRTQLegkayver 258
Cdd:COG4191 62 LELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQL-------- 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 259 yVHT------------LTHELKSPLAAIRGAAELL----QGDMSREQQQRFVGNIDSESARLQQLIERLLNLAqveqRQG 322
Cdd:COG4191 134 -VQSeklaalgelaagIAHEINNPLAAILGNAELLrrrlEDEPDPEELREALERILEGAERAAEIVRSLRAFS----RRD 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 323 LEEQSSIPLSALVEDVLKAQCARIEGAGLHVEQAIAADV-KVFGEPFLLRQALGNLLDNALDFTP--PGGTLRFSAQVQH 399
Cdd:COG4191 209 EEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINAIDAMEegEGGRITISTRREG 288
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 948124490 400 HEVQVTLFNQAEAIPDYALPRLSERFYSLPRPASGrksTGLGLNFVEEVMKLHGGTLQIGNVPGG 464
Cdd:COG4191 289 DYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKG---TGLGLSISYGIVEKHGGRIEVESEPGG 350
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
265-458 |
1.21e-22 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 100.43 E-value: 1.21e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 265 HELKSPLAAIRGAAELLQGDMSrEQQQRFVGNIDSESARLQQLIERLLNLAQveqRQGLEEQSsIPLSALVEDVLK---A 341
Cdd:COG5809 279 HEIRNPLTSLKGFIQLLKDTID-EEQKTYLDIMLSELDRIESIISEFLVLAK---PQAIKYEP-KDLNTLIEEVIPllqP 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 342 QcariegAGLH---VEQAIAADVK-VFGEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQ-HHEVQVTLFNQAEAIPDY 416
Cdd:COG5809 354 Q------ALLKnvqIELELEDDIPdILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEdDDKVVISVTDEGCGIPEE 427
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 948124490 417 ALPRLSERFYSlprpasgRKS--TGLGLNFVEEVMKLHGGTLQI 458
Cdd:COG5809 428 RLKKLGEPFYT-------TKEkgTGLGLMVSYKIIEEHGGKITV 464
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
370-471 |
1.31e-22 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 92.28 E-value: 1.31e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 370 LRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLpRPASGRKSTGLGLNFVEEVM 449
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRG-DKSREGGGTGLGLAIVRRIV 79
|
90 100
....*....|....*....|...
gi 948124490 450 KLHGGTLQIGNVPG-GVQAVLHL 471
Cdd:cd00075 80 EAHGGRITVESEPGgGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
365-464 |
1.11e-19 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 84.24 E-value: 1.11e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 365 GEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLPRPASGRKSTGLGLNF 444
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSI 80
|
90 100
....*....|....*....|
gi 948124490 445 VEEVMKLHGGTLQIGNVPGG 464
Cdd:smart00387 81 VKKLVELHGGEISVESEPGG 100
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-464 |
2.84e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 83.22 E-value: 2.84e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 357 IAADVKVFGEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHHEvQVTLFNQAEAIPDYALPRLSERFYSLprPASGRK 436
Cdd:cd16940 1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGA-VIRVEDNGPGIDEEELEALFERFYRS--DGQNYG 77
|
90 100
....*....|....*....|....*...
gi 948124490 437 STGLGLNFVEEVMKLHGGTLQIGNVPGG 464
Cdd:cd16940 78 GSGLGLSIVKRIVELHGGQIFLGNAQGG 105
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
235-471 |
2.08e-18 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 87.38 E-value: 2.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 235 ELKQLSTAVEHMRTQLEGKAYVER-YVHTLTHELKSPLAAIRGAAELLQgDMSREQQQRFVGNIDSESARLQQLIERLLN 313
Cdd:PRK10549 218 ELGRLAQDFNQLASTLEKNEQMRRdFMADISHELRTPLAVLRGELEAIQ-DGVRKFTPESVASLQAEVGTLTKLVDDLHQ 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 314 LAQVEQRQGLEEQSSIPLSALVEDVLKAQCARIEGAGLHVEQAIAADVKVFGEPFLLRQALGNLLDNALDFTPPGGTLRF 393
Cdd:PRK10549 297 LSLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHI 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 394 SAQVQHHEVQVTLFNQAEAIPDYALPRLSERFY----SLPRpASGrkSTGLGLNFVEEVMKLHGGTLQIGNVP-GGVQAV 468
Cdd:PRK10549 377 SAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYrtegSRNR-ASG--GSGLGLAICLNIVEAHNGRIIAAHSPfGGVSIT 453
|
...
gi 948124490 469 LHL 471
Cdd:PRK10549 454 VEL 456
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
235-458 |
1.68e-16 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 81.74 E-value: 1.68e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 235 ELKQLSTAVEHMRTQLEGkayveryVHT--------LTHELKSPLAAIRGAAE--LLQGDMSREQQQRFVGNIDsESARL 304
Cdd:PRK09835 240 ELEQLVLSFNHMIERIED-------VFTrqsnfsadIAHEIRTPITNLITQTEiaLSQSRSQKELEDVLYSNLE-ELTRM 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 305 QQLIERLLNLAQVEQRQGLEEQSSIPLSALVEDVL---------KAQCARIEGAGLHVEqaiaadvkvfGEPFLLRQALG 375
Cdd:PRK09835 312 AKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFdffeawaeeRGVELRFVGDPCQVA----------GDPLMLRRAIS 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 376 NLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLPrPASGRK--STGLGLNFVEEVMKLHG 453
Cdd:PRK09835 382 NLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVD-PSRQRKgeGSGIGLAIVKSIVVAHK 460
|
....*
gi 948124490 454 GTLQI 458
Cdd:PRK09835 461 GTVAV 465
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
231-463 |
3.77e-16 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 80.44 E-value: 3.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 231 YRGGELKQLSTAVEHMRtQLEGkayVER-YVHTLTHELKSPLAAIRGAAELLQG-DMSREQQQRFVGNIDSESARLQQLI 308
Cdd:PRK11006 182 YTEGQLLMVARDVTQMH-QLEG---ARRnFFANVSHELRTPLTVLQGYLEMMQDqPLEGALREKALHTMREQTQRMEGLV 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 309 ERLLNLAQVEQ--RQGLEEQSSIPLsalVEDVLKAQCARIEGAGLHVEQAIAADVKVFGEPFLLRQALGNLLDNALDFTP 386
Cdd:PRK11006 258 KQLLTLSKIEAapTIDLNEKVDVPM---MLRVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTP 334
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 948124490 387 PGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLPRpASGRKS--TGLGLNFVEEVMKLHGGTLQIGNVPG 463
Cdd:PRK11006 335 EGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDK-ARSRQTggSGLGLAIVKHALSHHDSRLEIESEVG 412
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
241-467 |
4.41e-16 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 79.63 E-value: 4.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 241 TAVEHMRTQLegkayVERYVHTL----------THELKSPLAAIRGAAELLqgdmsrEQQqrfvGNIDSES--ARLQQL- 307
Cdd:PRK10755 117 EAVTSALNQL-----VSRLTSTLdqerlftadvAHELRTPLAGIRLHLELL------EKQ----HHIDVAPliARLDQMm 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 308 --IERLLNLAQVEQR--QGLEEQSSiplsaLVEDVLKAQCARIEGAGLHVEQAI-----AADVKVFGEPFLLRQALGNLL 378
Cdd:PRK10755 182 htVEQLLQLARAGQSfsSGHYQTVK-----LLEDVILPSQDELSEMLEQRQQTLllpesAADITVQGDATLLRLLLRNLV 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 379 DNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLPRPASGrksTGLGLNFVEEVMKLHGGTLQI 458
Cdd:PRK10755 257 ENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSRYGG---IGLGLSIVSRITQLHHGQFFL 333
|
250
....*....|.
gi 948124490 459 GNVP--GGVQA 467
Cdd:PRK10755 334 QNRQerSGTRA 344
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
234-463 |
7.11e-16 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 79.22 E-value: 7.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 234 GELKQLSTAV-------EHMRTQLEGKayvERYVHTLTHELKSPLAAIRGAAELLQGDMSREQQQRFVGNIDS--ESARL 304
Cdd:PRK09303 125 QELLQLSDELfvlrqenETLLEQLKFK---DRVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPALIEQlqDQARR 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 305 Q-QLIERLL-NLAQVEQrqGLEEQSSI-P----LSALVEDVLKAQCARIEGAGLHVEQAIAADV-KVFGEPFLLRQALGN 376
Cdd:PRK09303 202 QlEEIERLItDLLEVGR--TRWEALRFnPqkldLGSLCQEVILELEKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLN 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 377 LLDNALDFTPPGGTLRFSAqvQH---HEVQVTLFNQAEAIPDYALPRLSERFYSLPRpASGRKSTGLGLNFVEEVMKLHG 453
Cdd:PRK09303 280 LLDNAIKYTPEGGTITLSM--LHrttQKVQVSICDTGPGIPEEEQERIFEDRVRLPR-DEGTEGYGIGLSVCRRIVRVHY 356
|
250
....*....|
gi 948124490 454 GTLQIGNVPG 463
Cdd:PRK09303 357 GQIWVDSEPG 366
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
365-471 |
1.37e-15 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 72.40 E-value: 1.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 365 GEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHHeVQVTLFNQAEAIPDYALPRLSERFYSLPRPASGRksTGLGLNF 444
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGG--TGLGLSI 77
|
90 100
....*....|....*....|....*...
gi 948124490 445 VEEVMKLHGGTLQIGNVPG-GVQAVLHL 471
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGgGTTVTLTL 105
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
265-458 |
1.79e-15 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 78.62 E-value: 1.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 265 HELKSPLAAIRGAAELLQgdMSREQQQRFVGNIDSESARLQQLIERLLNLAQvEQRQGLEEQSsipLSALVEDV---LKA 341
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQ--PGIEDKEEYFDIMLSELDRIESIISEFLALAK-PQAVNKEKEN---INELIQDVvtlLET 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 342 QcARIEGAGLHVEQaIAADVKVFGEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRL 421
Cdd:COG5805 370 E-AILHNIQIRLEL-LDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKL 447
|
170 180 190
....*....|....*....|....*....|....*..
gi 948124490 422 SERFYSLPrpasgRKSTGLGLNFVEEVMKLHGGTLQI 458
Cdd:COG5805 448 GEPFFTTK-----EKGTGLGLMVSYKIIENHNGTIDI 479
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
204-471 |
1.93e-15 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 78.44 E-value: 1.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 204 WWLTAAL----RRLTAYAEAVSEGRRAELPHYRGG--ELKQLSTAVEHMRTQLEGK-AYVERYVHTLTHELKSPLAAIRG 276
Cdd:PRK09470 184 LWLAWSLakpaRKLKNAADEVAQGNLRQHPELETGpqEFRQAGASFNQMVTALERMmTSQQRLLSDISHELRTPLTRLQL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 277 AAELL---QGDmSREQQQrfvgnIDSESARLQQLIERLLNLAQVEQRQGLEEQSsIPLSALVEDVLKAqcARIE----GA 349
Cdd:PRK09470 264 ATALLrrrQGE-SKELER-----IETEAQRLDSMINDLLVLSRNQQKNHLERET-FKANSLWSEVLED--AKFEaeqmGK 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 350 GLHVEqAIAADVKVFGEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQhhEVQVTLFNQAEAIPDYALPRLSERFYSLP 429
Cdd:PRK09470 335 SLTVS-APPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKD--GLTITVDDDGPGVPEEEREQIFRPFYRVD 411
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 948124490 430 RpASGRKS--TGLGLNFVEEVMKLHGGTLQIGNVP-GGVQAVLHL 471
Cdd:PRK09470 412 E-ARDRESggTGLGLAIVENAIQQHRGWVKAEDSPlGGLRLTIWL 455
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-471 |
7.56e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 70.57 E-value: 7.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 370 LRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFY---SLPRPASGrkSTGLGLNFVE 446
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYrveSSRNRASG--GSGLGLAICH 82
|
90 100
....*....|....*....|....*.
gi 948124490 447 EVMKLHGGTLQIGNVP-GGVQAVLHL 471
Cdd:cd16946 83 NIALAHGGTISAEHSPlGGLRLVLTL 108
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
257-319 |
3.26e-14 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 67.24 E-value: 3.26e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 948124490 257 ERYVHTLTHELKSPLAAIRGAAELLQGDMSREQQQRFVGNIDSESARLQQLIERLLNLAQVEQ 319
Cdd:pfam00512 3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
265-471 |
5.09e-14 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 74.23 E-value: 5.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 265 HELKSPLAAIRGAAELLQGDMSREQQQRFVGNIDSESARLQQLIERLLNLAQVEQRQgleeQSSIPLSALVEDVLKAQCA 344
Cdd:PRK11360 399 HEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQ----WQPVSLNALVEEVLQLFQT 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 345 RIEGAGLHVEQAIAADV-KVFGEPFLLRQALGNLLDNALDFTPPGGTLRFSA-QVQHHEVQVTLFNQAEAIPDYALPRLS 422
Cdd:PRK11360 475 AGVQARVDFETELDNELpPIWADPELLKQVLLNILINAVQAISARGKIRIRTwQYSDGQVAVSIEDNGCGIDPELLKKIF 554
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 948124490 423 ERFYSlPRPasgrKSTGLGLNFVEEVMKLHGGTLQIGNVPG-GVQAVLHL 471
Cdd:PRK11360 555 DPFFT-TKA----KGTGLGLALSQRIINAHGGDIEVESEPGvGTTFTLYL 599
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-463 |
6.59e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 67.61 E-value: 6.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 370 LRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLPRPASGRKS-TGLGLNFVEEV 448
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGgTGLGLAIVKHV 80
|
90
....*....|....*
gi 948124490 449 MKLHGGTLQIGNVPG 463
Cdd:cd16952 81 MSRHDARLLIASELG 95
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
257-319 |
9.03e-13 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 62.97 E-value: 9.03e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 948124490 257 ERYVHTLTHELKSPLAAIRGAAELLQGDMSREQQQRFVGNIDSESARLQQLIERLLNLAQVEQ 319
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
376-464 |
9.77e-13 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 64.44 E-value: 9.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 376 NLLDNALDFTPPGGTLRFSAQV-QHHEVQVTLFNQAEAIPDYALPRLSERFYSLPRPAS-GRKSTGLGLNFVEEVMKLHG 453
Cdd:cd16925 11 NLLSNAFKFTPDGGRIRCILEKfRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTrAHGGTGLGLSIVKEFVELHG 90
|
90
....*....|.
gi 948124490 454 GTLQIGNVPGG 464
Cdd:cd16925 91 GTVTVSDAPGG 101
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
209-478 |
4.03e-12 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 67.71 E-value: 4.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 209 ALRRLTAYAEAVSEGRRAELPHY-RGGELKQLSTAVEHMRTQLEGK-AYVERYVHTLTHELKSPLAAIRGAAELLQGDMS 286
Cdd:PRK10604 163 DMLKLEAAAQRLGDGHLAERIHFdEGSSLERLGVAFNQMADNINALiASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSA 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 287 REQQ--QRFVGNIDSesarlqqLIERLLNLAQVEqRQGLEEQSSIP-----LSALVEDV-LKAQCARIEGAGLHVEQAIA 358
Cdd:PRK10604 243 AESQalNRDIGQLEA-------LIEELLTYARLD-RPQNELHLSEPdlpawLSTHLADIqAVTPEKTVRLDTPHQGDYGA 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 359 ADvkvfgePFLLRQALGNLLDNALDFTppGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLpRPASGRKS- 437
Cdd:PRK10604 315 LD------MRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRL-DPSRDRATg 385
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 948124490 438 -TGLGLNFVEEVMKLHGGTLQIGNVP-GGVQAVLHLHTVSTLP 478
Cdd:PRK10604 386 gCGLGLAIVHSIALAMGGSVNCDESElGGARFSFSWPVWHNLP 428
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
257-316 |
5.35e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 60.69 E-value: 5.35e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 948124490 257 ERYVHTLTHELKSPLAAIRGAAELLQGDMSR-EQQQRFVGNIDSESARLQQLIERLLNLAQ 316
Cdd:cd00082 5 GEFLANVSHELRTPLTAIRGALELLEEELLDdEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
265-463 |
1.93e-11 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 65.96 E-value: 1.93e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 265 HELKSPLAAIRG-----AAELLQGDMSREQQQRFVGNIDsesaRLQQLIERLLNLAQVEQrqgLEEQSsIPLSALVEDVL 339
Cdd:PRK10364 246 HEIRNPLSSIKGlakyfAERAPAGGEAHQLAQVMAKEAD----RLNRVVSELLELVKPTH---LALQA-VDLNDLINHSL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 340 KAQCARIEGAGLHVEQAIAADVK-VFGEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYAL 418
Cdd:PRK10364 318 QLVSQDANSREIQLRFTANDTLPeIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQL 397
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 948124490 419 PRLSERFYSlprpaSGRKSTGLGLNFVEEVMKLHGGTLQIGNVPG 463
Cdd:PRK10364 398 EAIFTPYFT-----TKAEGTGLGLAVVHNIVEQHGGTIQVASQEG 437
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
235-463 |
2.18e-11 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 66.30 E-value: 2.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 235 ELKQLSTAVEHMRTQ-LEGKAYVERYVHTLTHELKSPLAAIRGAAELLQGD-MSREQQQRFVGNIDSESARLQQLIERLL 312
Cdd:PRK09959 690 ETRDLIHALEVERNKaINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSgLSKEQRVEAISLAYATGQSLLGLIGEIL 769
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 313 NLAQVEQRQGLEEQSSIPLSALVEDVLKA--QCARIEGAGLHVEQAIAADVKVFGEPFLLRQALGNLLDNALDFTPPGGT 390
Cdd:PRK09959 770 DVDKIESGNYQLQPQWVDIPTLVQNTCHSfgAIAASKSIALSCSSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAV 849
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 948124490 391 LRFSAQVQ----HHEVQVTLFNQAEAIPDYALPRLSERFyslPRPASGRKST--GLGLNFVEEVMKLHGGTLQIGNVPG 463
Cdd:PRK09959 850 KITTSLGHiddnHAVIKMTIMDSGSGLSQEEQQQLFKRY---SQTSAGRQQTgsGLGLMICKELIKNMQGDLSLESHPG 925
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
204-467 |
2.48e-11 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 65.32 E-value: 2.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 204 WW----LTAALRRLTAYAEAVSEGRRAE-LPHYRGGELKQLSTAVEHMRT---QLEGkayvERyvhTL-----THELKSP 270
Cdd:PRK09467 171 WLfiriQNRPLVALEHAALQVGKGEIPPpLREYGASEVRSVTRAFNQMAAgikQLED----DR---TLlmagvSHDLRTP 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 271 LAAIRGAAELlqgdMSREQQ---QRFVGNIDSESARLQQLIERLlnlaqveqRQGLEEQSS-IPLSALVEDVLKAQcari 346
Cdd:PRK09467 244 LTRIRLATEM----MSEEDGylaESINKDIEECNAIIEQFIDYL--------RTGQEMPMEmADLNALLGEVIAAE---- 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 347 EGAGLHVEQAIAA-DVKVFGEPFLLRQALGNLLDNALDFTppGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERF 425
Cdd:PRK09467 308 SGYEREIETALQPgPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPF 385
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 948124490 426 yslPRPASGRKS--TGLGLNFVEEVMKLHGGTLQIGNVP-GGVQA 467
Cdd:PRK09467 386 ---TRGDSARGSsgTGLGLAIVKRIVDQHNGKVELGNSEeGGLSA 427
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
262-463 |
6.02e-10 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 61.58 E-value: 6.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 262 TLTHELKSPLAAIRGAAELLQGDMSREQQQRFVGNIDSESARLQQLIERLLNLAQVEQRQ---GLEEQSSIPLsaLVEDV 338
Cdd:PRK15347 404 TISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTARQCTLSLLAIINNLLDFSRIESGQmtlSLEETALLPL--LDQAM 481
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 339 LKAQcARIEGAGLHVEQAIAADV--KVFGEPFLLRQALGNLLDNALDFTPPGGtLRFSAQVQHHEVQVTLFNQAEAIPDY 416
Cdd:PRK15347 482 LTIQ-GPAQSKSLTLRTFVGAHVplYLHLDSLRLRQILVNLLGNAVKFTETGG-IRLRVKRHEQQLCFTVEDTGCGIDIQ 559
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 948124490 417 ALPRLSERFYSLPRPASGrksTGLGLNFVEEVMKLHGGTLQIGNVPG 463
Cdd:PRK15347 560 QQQQIFTPFYQADTHSQG---TGLGLTIASSLAKMMGGELTLFSTPG 603
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
241-464 |
1.20e-09 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 59.86 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 241 TAVEHMRTQLEGkayVERYVHTL---THELKSPLAAIRGAAELlqgdmsreqqqrfvGNIDsesaRLQQLIERLLNLAQV 317
Cdd:COG3290 174 TELERLEEELEG---VKELAEALraqRHDFRNHLHTISGLLQL--------------GEYD----EALEYIDEISEELQE 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 318 EQRQGLEEQSSIPLSALVEDvlKAQCARIEGAGLHVEqaIAADVKVFG-EPFLLRQALGNLLDNALD----FTPPGGTLR 392
Cdd:COG3290 233 LIDSLLSRIGNPVLAALLLG--KAARARERGIDLTID--IDSDLPDLPlSDTDLVTILGNLLDNAIEavekLPEEERRVE 308
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 948124490 393 FSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLPrpasGRKSTGLGLNFVEEVMKLHGGTLQIGNVPGG 464
Cdd:COG3290 309 LSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTK----LGEGRGLGLALVKQIVEKYGGTIEVESEEGE 376
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
226-463 |
1.89e-09 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 60.30 E-value: 1.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 226 AELPHYRGGELKQLstAVEHMRTQLEGKAYVE---RYVHTLTHELKSPLAAIRGAAELLQGDMSREQQQRFVGNIDSESA 302
Cdd:PRK11466 413 AAQVKARTAELQEL--VIEHRQARAEAEKASQaksAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGE 490
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 303 RLQQLIERLLNLAQVEQRQGLEEQSSIPLS--ALVEDVLKAQCARIEGAGLHVEQAIAADVKVF--GEPFLLRQALGNLL 378
Cdd:PRK11466 491 SLLTILNDILDYSAIEAGGKNVSVSDEPFEprPLLESTLQLMSGRVKGRPIRLATDIADDLPTAlmGDPRRIRQVITNLL 570
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 379 DNALDFTPPGG-TLRFSAQVQHHEVQVTlfNQAEAIPDYALPRLSERFYSLprpaSGRK-STGLGLNFVEEVMKLHGGTL 456
Cdd:PRK11466 571 SNALRFTDEGSiVLRSRTDGEQWLVEVE--DSGCGIDPAKLAEIFQPFVQV----SGKRgGTGLGLTISSRLAQAMGGEL 644
|
....*..
gi 948124490 457 QIGNVPG 463
Cdd:PRK11466 645 SATSTPE 651
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-456 |
2.00e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 54.89 E-value: 2.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 370 LRQALGNLLDNALDFTPPG-GTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSlPRPAS---GRKStGLGLNFV 445
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYT-ERPANeafGQHS-GLGLSIS 78
|
90
....*....|.
gi 948124490 446 EEVMKLHGGTL 456
Cdd:cd16953 79 RQIIEAHGGIS 89
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-471 |
2.69e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 54.64 E-value: 2.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 370 LRQALGNLLDNALDFTPpgGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYslpRPASGRKS----TGLGLNFV 445
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFY---RVDSARDResggTGLGLAIA 75
|
90 100
....*....|....*....|....*..
gi 948124490 446 EEVMKLHGGTLQIGNV-PGGVQAVLHL 471
Cdd:cd16949 76 ERAIEQHGGKIKASNRkPGGLRVRIWL 102
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
370-463 |
3.92e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 54.04 E-value: 3.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 370 LRQALGNLLDNALDFTPPGG-TLRFSAQVQHHEVQVTLFNQAEA---IPDYALPRLSERFY----SLPRPASGrksTGLG 441
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEDGVQLRFSVEDTgigIPEEQQARLFEPFSqadsSTTRKYGG---TGLG 77
|
90 100
....*....|....*....|..
gi 948124490 442 LNFVEEVMKLHGGTLQIGNVPG 463
Cdd:cd16922 78 LAISKKLVELMGGDISVESEPG 99
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
263-478 |
6.00e-09 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 58.51 E-value: 6.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 263 LTHELKSPLAAIRGAAELLQGDMSREQ----QQrfVGNIDSESARLQQLIERLLNLAQVE--------QRQGLEEqssIP 330
Cdd:PRK10490 671 LSHDLRTPLTVLFGQAEILTLDLASEGsphaRQ--ASEIRQQVLNTTRLVNNLLDMARIQsggfnlrkEWLTLEE---VV 745
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 331 LSAL--VEDVLkaqcariegAGLHVEQAIAAD-VKVFGEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLF 407
Cdd:PRK10490 746 GSALqmLEPGL---------SGHPINLSLPEPlTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVW 816
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 948124490 408 NQAEAIPDYALPRLSERFyslprpASGRKST-----GLGLNFVEEVMKLHGGTLQIGNVPGGvQAVLHLhtvsTLP 478
Cdd:PRK10490 817 DNGPGIPPGQEQLIFDKF------ARGNKESaipgvGLGLAICRAIVEVHGGTIWAENRPEG-GACFRV----TLP 881
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-458 |
8.81e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 52.77 E-value: 8.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 370 LRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYslpRPASGRKS--TGLGLNFVEE 447
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFY---RGDNSRNTegAGLGLSIAKA 77
|
90
....*....|.
gi 948124490 448 VMKLHGGTLQI 458
Cdd:cd16923 78 IIELHGGSASA 88
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-464 |
1.04e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 52.81 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 367 PFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLPRPASGrksTGLGLNFVE 446
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEG---TGLGLSLSY 77
|
90
....*....|....*...
gi 948124490 447 EVMKLHGGTLQIGNVPGG 464
Cdd:cd16943 78 RIIQKHGGTIRVASVPGG 95
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-464 |
6.88e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 50.53 E-value: 6.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 370 LRQALGNLLDNALDFTppGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLPRpASGRKSTGLGLNFVEEVM 449
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDN-ARGTSGTGLGLAIVQRIS 77
|
90
....*....|....*
gi 948124490 450 KLHGGTLQIGNVPGG 464
Cdd:cd16950 78 DAHGGSLTLANRAGG 92
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
260-463 |
8.23e-08 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 53.93 E-value: 8.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 260 VHTLTHELKSPLAAIRGAAELLQGDMSREQQQRFVGNIDSESARLQQLIERLLNlaqvEQRQGLEEQSSIplSALVEDVl 339
Cdd:PRK11073 134 VRGLAHEIKNPLGGLRGAAQLLSKALPDPALTEYTKVIIEQADRLRNLVDRLLG----PQRPGTHVTESI--HKVAERV- 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 340 kAQCARIE-GAGLHVEQAIAADVKVFG-EPFLLRQALGNLLDNALD-FTPPGGTLRFSAQVQHhevQVTLFNQ------- 409
Cdd:PRK11073 207 -VQLVSLElPDNVRLIRDYDPSLPELAhDPDQIEQVLLNIVRNALQaLGPEGGTITLRTRTAF---QLTLHGEryrlaar 282
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 948124490 410 ------AEAIPDYALPRLserFYSLprpASGRK-STGLGLNFVEEVMKLHGGTLQIGNVPG 463
Cdd:PRK11073 283 idiednGPGIPPHLQDTL---FYPM---VSGREgGTGLGLSIARNLIDQHSGKIEFTSWPG 337
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
261-472 |
2.47e-07 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 53.40 E-value: 2.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 261 HTLTHELKSPLAAIRGAAELLQGDMSREQQQRFVGNIDSESARLQQLIERLLNLAQVEQRQGLEEQSSIPLSALVEDVLK 340
Cdd:PRK10618 455 QNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDLIDEVLP 534
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 341 AQCARIEGAGL----HVEqaIAADVKVFGEPFLLRQALGNLLDNALDFTPPGG-TLRFSAQVQHHE-VQVTLFNQAEAIP 414
Cdd:PRK10618 535 EVLPAIKRKGLqlliHNH--LKAEQLRIGDRDALRKILLLLLNYAITTTAYGKiTLEVDQDESSPDrLTIRILDTGAGVS 612
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 948124490 415 DYALPRLseRFYSLPRPASGRKSTGLGLNF--VEEVMKLHGGTLQIGNVPG-GVQAVLHLH 472
Cdd:PRK10618 613 IKELDNL--HFPFLNQTQGDRYGKASGLTFflCNQLCRKLGGHLTIKSREGlGTRYSIHLK 671
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-464 |
5.80e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 47.84 E-value: 5.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 370 LRQALGNLLDNALDFTP--PGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSlPRPASgrKSTGLGLNFVEE 447
Cdd:cd16976 1 IQQVLMNLLQNALDAMGkvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-TKPVG--KGTGLGLSISYG 77
|
90
....*....|....*..
gi 948124490 448 VMKLHGGTLQIGNVPGG 464
Cdd:cd16976 78 IVEEHGGRLSVANEEGA 94
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
262-463 |
6.09e-07 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 52.28 E-value: 6.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 262 TLTHELKSPLAAIRGAAELLQGDMSREQQQRFVGNIDSESARLQQLIERLLNLAQVEQRQ-GLEEQSSIP---------- 330
Cdd:PRK10841 453 TVSHELRTPLYGIIGNLDLLQTKELPKGVDRLVTAMNNSSSLLLKIISDILDFSKIESEQlKIEPREFSPrevinhitan 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 331 -LSALVEDVLKAQCAriegaglhveqaIAADVKV--FGEPFLLRQALGNLLDNALDFTPPGGTLrFSAQVQHHEVQVTLF 407
Cdd:PRK10841 533 yLPLVVKKRLGLYCF------------IEPDVPValNGDPMRLQQVISNLLSNAIKFTDTGCIV-LHVRVDGDYLSFRVR 599
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 408 NQAEAIPDYALPRLSERFYSL----PRPASGrksTGLGLNFVEEVMKLHGGTLQIGNVPG 463
Cdd:PRK10841 600 DTGVGIPAKEVVRLFDPFFQVgtgvQRNFQG---TGLGLAICEKLINMMDGDISVDSEPG 656
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
265-463 |
1.05e-06 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 51.21 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 265 HELKSPLAAIRGAAELLQ-----GDMSREQQQRFVGNIDSESARLQQLIERLLNLAQVEQRQGleeqSSIPLSALVEDvL 339
Cdd:PRK13557 172 HDFNNLLQVMSGYLDVIQaalshPDADRGRMARSVENIRAAAERAATLTQQLLAFARKQRLEG----RVLNLNGLVSG-M 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 340 KAQCARIEGAGLHVEQAIAADVKVFG-EPFLLRQALGNLLDNALDFTPPGGTLRFSAQ---VQHHE------------VQ 403
Cdd:PRK13557 247 GELAERTLGDAVTIETDLAPDLWNCRiDPTQAEVALLNVLINARDAMPEGGRVTIRTRnveIEDEDlamyhglppgryVS 326
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 404 VTLFNQAEAIPDYALPRLSERFYSLPRPASGrksTGLGLNFVEEVMKLHGGTLQIGNVPG 463
Cdd:PRK13557 327 IAVTDTGSGMPPEILARVMDPFFTTKEEGKG---TGLGLSMVYGFAKQSGGAVRIYSEVG 383
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-464 |
1.21e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 47.07 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 369 LLRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLPRPASGRKSTGLGLNFVEEV 448
Cdd:cd16975 4 LLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIAKNL 83
|
90
....*....|....*..
gi 948124490 449 MKLHGGTLQIGN-VPGG 464
Cdd:cd16975 84 VEKHGGSLIIENsQKGG 100
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-464 |
1.28e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 47.15 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 369 LLRQALGNLLDNALD------FTPPGGTLRFSAQvQHHEVQVTLFNQAEAIPDYALPRLSERfYSLPRPasgrKSTGLGL 442
Cdd:cd16944 4 QISQVLTNILKNAAEaiegrpSDVGEVRIRVEAD-QDGRIVLIVCDNGKGFPREMRHRATEP-YVTTRP----KGTGLGL 77
|
90 100
....*....|....*....|..
gi 948124490 443 NFVEEVMKLHGGTLQIGNVPGG 464
Cdd:cd16944 78 AIVKKIMEEHGGRISLSNREAG 99
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
244-463 |
1.66e-06 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 50.71 E-value: 1.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 244 EHMRTQ--LEgKAYVER--YVHTLTHELKSPLAAIRGAAE-LLQGDMSREQQQrFVGNIDSESARLQQLIERLLNLAQVE 318
Cdd:PRK11091 268 ERKRYQdaLE-KASRDKttFISTISHELRTPLNGIVGLSRiLLDTELTAEQRK-YLKTIHVSAITLGNIFNDIIDMDKME 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 319 QRQGLEEQSSIPLSALVEDV--LKAQCARIEGAGLHVEQAIAADVKVFGEPFLLRQALGNLLDNALDFTPPGG-TLRFSA 395
Cdd:PRK11091 346 RRKLQLDNQPIDFTDFLADLenLSGLQAEQKGLRFDLEPLLPLPHKVITDGTRLRQILWNLISNAVKFTQQGGvTVRVRY 425
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 948124490 396 QVQ---HHEVQVTlfnqAEAIPDYALPRLSERFYSLP-----RPASGrksTGLGLNFVEEVMKLHGGTLQIGNVPG 463
Cdd:PRK11091 426 EEGdmlTFEVEDS----GIGIPEDELDKIFAMYYQVKdshggKPATG---TGIGLAVSKRLAQAMGGDITVTSEEG 494
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
248-458 |
4.58e-06 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 49.30 E-value: 4.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 248 TQLEGKAYVERYVHTLTHELKSPLAAIRgaAELLQGDMSREQQQ-----RFVGNIDSESARLQQLIERLLNLAqveqRQG 322
Cdd:COG4192 425 IQAAKMAVVGQTMTSLAHELNQPLNAMS--MYLFSAKKALEQENyaqlpTSLDKIEGLIERMDKIIKSLRQFS----RKS 498
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 323 LEEQSSIPLSALVED--VLKAQCARIEGAGLHVEQaiaaDVKVFGEPFLLRQALGNLLDNALDF--TPPGGTLRFSAQVQ 398
Cdd:COG4192 499 DTPLQPVDLRQVIEQawELVESRAKPQQITLHIPD----DLMVQGDQVLLEQVLVNLLVNALDAvaTQPQISVDLLSNAE 574
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 399 HHEVQVTLFNQAEAIpdyaLPRLSERFYSlprpaSGRKSTGLGLNFVEEVMKLHGGTLQI 458
Cdd:COG4192 575 NLRVAISDNGNGWPL----VDKLFTPFTT-----TKEVGLGLGLSICRSIMQQFGGDLYL 625
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
204-251 |
2.37e-05 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 41.85 E-value: 2.37e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 948124490 204 WWLTAALRRLTAYAEAVSEGR-RAELPHYRGGELKQLSTAVEHMRTQLE 251
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDlTVRLPVDGRDEIGELARAFNEMADRLE 49
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
265-463 |
2.37e-05 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 46.98 E-value: 2.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 265 HELKSPLAAIRGAAELLQGDMSREQQ-QRFVGNIDSESARLQQLIERLLNLAQVEQRQgleeQSSIPLSALVEDV---LK 340
Cdd:PRK13837 459 HNFNNILGAILGYAEMALNKLARHSRaARYIDEIISAGARARLIIDQILAFGRKGERN----TKPFDLSELVTEIaplLR 534
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 341 AQCARieGAGLHVEQAiAADVKVFGEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQ---------HHE------VQVT 405
Cdd:PRK13837 535 VSLPP--GVELDFDQD-QEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAklrapkvlsHGVlppgryVLLR 611
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 948124490 406 LFNQAEAIPDYALPRLSERFYSlPRPAsgrkSTGLGLNFVEEVMKLHGGTLQIGNVPG 463
Cdd:PRK13837 612 VSDTGAGIDEAVLPHIFEPFFT-TRAG----GTGLGLATVHGIVSAHAGYIDVQSTVG 664
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-463 |
1.27e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 41.23 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 370 LRQALGNLLDNALDFTPP-GGTLRFSAQVQHhevQVTLFNQ-------------AEAIPDYALPRLserFYSLprpASGR 435
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGsGGEIILRTRTQR---QVTLGHPrhrlalrvsvidnGPGIPPDLQDTI---FYPM---VSGR 71
|
90 100
....*....|....*....|....*....
gi 948124490 436 KS-TGLGLNFVEEVMKLHGGTLQIGNVPG 463
Cdd:cd16918 72 ENgTGLGLAIAQNIVSQHGGVIECDSQPG 100
|
|
| PDC1_HK_sensor |
cd18773 |
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase ... |
40-167 |
1.65e-04 |
|
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase and similar domains; Histidine kinase (HK) receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. HK receptors in this family contain double PDC (PhoQ/DcuS/CitA) sensor domains. Signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses. The HK family includes not just histidine kinase receptors but also sensors for chemotaxis proteins and diguanylate cyclase receptors, implying a combinatorial molecular evolution.
Pssm-ID: 350341 [Multi-domain] Cd Length: 125 Bit Score: 41.39 E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 40 ETLVDTANLLAEILREDVKNGTLGQSHWPALLKAYGNRQPGAviwglpknqvnHRIYVTDAKGRVLLDSSGEAVGQDYSK 119
Cdd:cd18773 2 EEADLLLRSLASALEALAALGSADREELQALLRRLLERNPEI-----------SGIYVVDADGRVVASSDRDPGGGDDDD 70
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 948124490 120 WNDVYLTLRGEYGARSTRSDA--DDATSS-VMHVGAPIRD-NGQIIGVVTVA 167
Cdd:cd18773 71 DRDRFWYQAAKATGKLVISEPyiSRVTGKpVITLSRPIRDaDGRFIGVVGAD 122
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
374-464 |
2.46e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 40.35 E-value: 2.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 374 LGNLLDNALDFT----PPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSlPRPASGRkstGLGLNFVEEVM 449
Cdd:cd16915 5 VGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-TKGQGER---GIGLALVRQSV 80
|
90
....*....|....*
gi 948124490 450 KLHGGTLQIGNVPGG 464
Cdd:cd16915 81 ERLGGSITVESEPGG 95
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-448 |
3.80e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 39.96 E-value: 3.80e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 948124490 370 LRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLPRPASGRKSTGLGLNFVEEV 448
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYLVKKL 84
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
210-250 |
6.09e-04 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 37.42 E-value: 6.09e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 948124490 210 LRRLTAYAEAVSEGR-RAELPHYRGGELKQLSTAVEHMRTQL 250
Cdd:cd06225 4 LRRLTEAARRIAEGDlDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
89-185 |
9.36e-04 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 41.68 E-value: 9.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 89 NQVNHRIYVTDAKGRVLL----------DSSGEAVGQ---DYSKWNDVYLTLRGEYGARSTRSDADDATSSVMHVGAPIR 155
Cdd:COG3829 18 DSLDDGIIVVDADGRITYvnraaerilgLPREEVIGKnvtELIPNSPLLEVLKTGKPVTGVIQKTGGKGKTVIVTAIPIF 97
|
90 100 110
....*....|....*....|....*....|
gi 948124490 156 DNGQIIGVVTVAKPNSSLQPYVDRTERRLL 185
Cdd:COG3829 98 EDGEVIGAVETFRDITELKRLERKLREEEL 127
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-471 |
1.37e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 38.18 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 370 LRQALGNLLDNALDFTppGGTLRFSAQVQHHEVQVTLFNQAEAIPDYALPRLSERFYSLPrPASGRKSTG--LGLNFVEE 447
Cdd:cd16939 1 MARALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLD-PSRDRATGGfgLGLAIVHR 77
|
90 100
....*....|....*....|....*
gi 948124490 448 VMKLHGGTLQIGNVP-GGVQAVLHL 471
Cdd:cd16939 78 VALWHGGHVECDDSElGGACFRLTW 102
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
205-464 |
2.06e-03 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 40.39 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 205 WLTA--ALRRLTAYAEAVSE---GRRAELPHYRGGELKQLstaVEHMRTQL--EGKAYvERYVHTL---THELKSPLAAI 274
Cdd:PRK10815 209 WLAAwwSLRPIEALAKQVREleeGEREQLDPNPPRELTSL---VRNLNRLLknERERY-TKYRTTLtdlTHSLKTPLAVL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 275 RGAAELLQG--DMSREQQQRFvgnIDSESARLQQLIERLLNLAQVEQRQGLEEQSSIPLSALVEDVLKAQCARIEGAGLH 352
Cdd:PRK10815 285 QSTLRSLRSgkQMSVEQAEPI---MLEQISRISQQIGYYLHRASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVN 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 353 VEQAIAADVKVFGEPFLLRQALGNLLDNA----LDFtppggtLRFSAQVQHHEVQVTLFNQAEAIPDyalprlSER---F 425
Cdd:PRK10815 362 ITLDISPEITFVGEKNDFMEVMGNVLDNAckycLEF------VEISARQTDEHLHIVVEDDGPGIPE------SKReliF 429
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 948124490 426 YSLPRPASGRKSTGLGLNFVEEVMKLHGGTLQIGNVP-GG 464
Cdd:PRK10815 430 DRGQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPlGG 469
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-464 |
4.42e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 36.92 E-value: 4.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 370 LRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAI---PDYAlPRLSERFYSL-PRPASGrkSTGLGLNFV 445
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIgidPEYA-EKVFGIFQRLhSREEYE--GTGVGLAIV 77
|
90
....*....|....*....
gi 948124490 446 EEVMKLHGGTLQIGNVPGG 464
Cdd:cd16921 78 RKIIERHGGRIWLESEPGE 96
|
|
| sCache_like |
pfam16736 |
Single Cache-like; This entry represents the N-terminal Cache-like domain of the alkaline ... |
90-167 |
4.71e-03 |
|
Single Cache-like; This entry represents the N-terminal Cache-like domain of the alkaline phosphatase synthesis sensor protein PhoR. It covers part of the PAS-like fold that share a central five-stranded beta- sheet of identical topology to other PAS domains.
Pssm-ID: 407005 Cd Length: 114 Bit Score: 36.98 E-value: 4.71e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 948124490 90 QVNHRIYVTDAKGRVLLDSSGEAVGQDYSKwnDVYLTLRGEYGARSTRSDADdaTSSVMHVGAPIRDNGQIIGVVTVA 167
Cdd:pfam16736 40 KLDARITIIDADGKVLYDTGGETEDAEHEA--IIQELLSGEELQEVRVITTD--EDDLLYYAVPIQKEGEQEGYILLS 113
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
203-413 |
5.48e-03 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 39.33 E-value: 5.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 203 SWWLTAALRRLTAYAEAVSEGRR-AELPHYRGGELKQLSTAVEHMRTQLEGKAYVERYVHTLTHELKSPLAAIRGAAELL 281
Cdd:COG2770 233 ARRITRPLRRLAEAARRIAAGDLdVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLA 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 282 QGDMSREQQQRFVGNIDSESARLQQLIERLLNLAQVEQRQGLEEQSSIPLSALVEDVLKAQCARIEGAGLHVEQAIAADV 361
Cdd:COG2770 313 LLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVL 392
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 948124490 362 KVFGEPFLLRQALGNLLDNALDFTPPGGTLRFSAQVQHHEVQVTLFNQAEAI 413
Cdd:COG2770 393 ALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAA 444
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
370-463 |
7.30e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 36.59 E-value: 7.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948124490 370 LRQALGNLLDNALDFTPPGGTLRFSA---------QVQHHE------VQVTLFNQAEAIPDYALPRLSERFYSLPRPASG 434
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETsnqrvdadyALNYRDlipgnyVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKG 80
|
90 100
....*....|....*....|....*....
gi 948124490 435 rksTGLGLNFVEEVMKLHGGTLQIGNVPG 463
Cdd:cd16919 81 ---TGLGLSMVYGFVKQSGGHLRIYSEPG 106
|
|
| |
