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Conserved domains on  [gi|947860480|ref|WP_056521122|]
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MULTISPECIES: response regulator [Methylobacterium]

Protein Classification

DNA-binding transcriptional response regulator( domain architecture ID 1000064)

DNA-binding transcriptional response regulator similar to NtrC family, containing REC, sigma-54 interaction, and a Fis-type DNA-binding domains, and to the two-component regulatory system HrpR/HrpS that regulates the activation of the sigma factor hrpL

Gene Ontology:  GO:0043565|GO:0006355|GO:0000160

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AtoC super family cl34427
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 6-117 8.13e-17

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG2204:

Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 74.61  E-value: 8.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   6 SKPTALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGRvDGIRLAQLIAERWPETAVM 85
Cdd:COG2204    1 SMARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEP-PDLVLLDLRMPGM-DGLELLRELRALDPDLPVI 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 947860480  86 VCSGplafrpRTLPDKAR---------FFPKPFSLNEVSAT 117
Cdd:COG2204   79 LLTG------YGDVETAVeaikagafdYLTKPFDLEELLAA 113
 
Name Accession Description Interval E-value
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 6-117 8.13e-17

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 74.61  E-value: 8.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   6 SKPTALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGRvDGIRLAQLIAERWPETAVM 85
Cdd:COG2204    1 SMARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEP-PDLVLLDLRMPGM-DGLELLRELRALDPDLPVI 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 947860480  86 VCSGplafrpRTLPDKAR---------FFPKPFSLNEVSAT 117
Cdd:COG2204   79 LLTG------YGDVETAVeaikagafdYLTKPFDLEELLAA 113
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 11-89 4.77e-15

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 65.82  E-value: 4.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480  11 LIVEDENITR--METMDVFADAGFDVI-EAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLIAERWPETAVMVC 87
Cdd:cd17536    2 LIVDDEPLIRegLKKLIDWEELGFEVVgEAENGEEALELIEEHK-PDIVITDIRMPG-MDGLELIEKIRELYPDIKIIIL 79


                 ..
gi 947860480  88 SG 89
Cdd:cd17536   80 SG 81
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 11-113 5.39e-13

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 60.24  E-value: 5.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLpTIQLVFTDVRMPGrVDGIRLAQLIAERWPETAVMVCS-- 88
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEE-RPDLILLDINMPG-MDGLELLKRIRRRDPTTPVIILTah 79

                          90       100
                  ....*....|....*....|....*.
gi 947860480   89 GPLAFRPRTLPDKAR-FFPKPFSLNE 113
Cdd:pfam00072  80 GDEDDAVEALEAGADdFLSKPFDPDE 105
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
9-114 1.34e-08

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 51.39  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   9 TALIVEDE-NITRMETMdVFADAGFDVIEAWTGDMALHLLGRLPTiQLVFTDVRMPgRVDGIRLAQLIAERWPETAV--M 85
Cdd:PRK11361   6 RILIVDDEdNVRRMLST-AFALQGFETHCANNGRTALHLFADIHP-DVVLMDIRMP-EMDGIKALKEMRSHETRTPVilM 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 947860480  86 VCSGPLAFRPRTLPDKA-RFFPKPFSLNEV 114
Cdd:PRK11361  83 TAYAEVETAVEALRCGAfDYVIKPFDLDEL 112
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 11-63 3.84e-07

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 43.71  E-value: 3.84e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 947860480    11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMP 63
Cdd:smart00448   4 LVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEK-PDLILLDIMMP 55
 
Name Accession Description Interval E-value
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 6-117 8.13e-17

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 74.61  E-value: 8.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   6 SKPTALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGRvDGIRLAQLIAERWPETAVM 85
Cdd:COG2204    1 SMARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEP-PDLVLLDLRMPGM-DGLELLRELRALDPDLPVI 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 947860480  86 VCSGplafrpRTLPDKAR---------FFPKPFSLNEVSAT 117
Cdd:COG2204   79 LLTG------YGDVETAVeaikagafdYLTKPFDLEELLAA 113
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 11-89 1.47e-15

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 66.72  E-value: 1.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480  11 LIVEDENITRMETMDVFAD-AGFDVI-EAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLIAERWPETAVMVCS 88
Cdd:COG4753    3 LIVDDEPLIREGLKRILEWeAGFEVVgEAENGEEALELLEEHK-PDLVITDINMPG-MDGLELLEAIRELDPDTKIIILS 80


                 .
gi 947860480  89 G 89
Cdd:COG4753   81 G 81
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 11-89 4.77e-15

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 65.82  E-value: 4.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480  11 LIVEDENITR--METMDVFADAGFDVI-EAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLIAERWPETAVMVC 87
Cdd:cd17536    2 LIVDDEPLIRegLKKLIDWEELGFEVVgEAENGEEALELIEEHK-PDIVITDIRMPG-MDGLELIEKIRELYPDIKIIIL 79


                 ..
gi 947860480  88 SG 89
Cdd:cd17536   80 SG 81
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 11-89 6.16e-14

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 62.75  E-value: 6.16e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPTIQLVFTDVRMPGRVDGIRLAQLIAERWPETAVMVCSG 89
Cdd:cd18161    2 LVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDLLESGPDIDLLVTDVIMPGGMNGSQLAEEARRRRPDLKVLLTSG 80
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 6-123 9.63e-14

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 62.56  E-value: 9.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   6 SKPTALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLI--AERWPETA 83
Cdd:COG0784    4 GGKRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGP-PDLILLDINMPG-MDGLELLRRIraLPRLPDIP 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 947860480  84 VMVCSgplAFRPRTLPDKAR------FFPKPFSLNEVSATALALVA 123
Cdd:COG0784   82 IIALT---AYADEEDRERALeagaddYLTKPVDPEELLEALRRLLA 124
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 11-113 5.39e-13

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 60.24  E-value: 5.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLpTIQLVFTDVRMPGrVDGIRLAQLIAERWPETAVMVCS-- 88
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEE-RPDLILLDINMPG-MDGLELLKRIRRRDPTTPVIILTah 79

                          90       100
                  ....*....|....*....|....*.
gi 947860480   89 GPLAFRPRTLPDKAR-FFPKPFSLNE 113
Cdd:pfam00072  80 GDEDDAVEALEAGADdFLSKPFDPDE 105
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 11-89 8.63e-13

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 59.93  E-value: 8.63e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLIAERWPETAVMVCSG 89
Cdd:cd17554    4 LVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESED-PDLVILDIKMPG-MDGLETLRKIREKKPDLPVIICTA 80
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 11-89 2.40e-12

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 58.39  E-value: 2.40e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRlPTIQLVFTDVRMPGrVDGIRLAQLIAERWPETAVMVCSG 89
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLRE-ERPDLVLLDLMMPG-MDGLELLRKLRELPPDIPVIVLTA 77
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 7-122 9.82e-12

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 59.20  E-value: 9.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   7 KPTALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLIAERWPETAVMV 86
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEER-PDLILLDLMLPG-MDGLEVCRRLRARPSDIPIIM 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 947860480  87 CSGplafrPRTLPDKAR--------FFPKPFSLNEVSATALALV 122
Cdd:COG0745   79 LTA-----RDDEEDRVRgleagaddYLTKPFDPEELLARIRALL 117
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 6-116 1.32e-11

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 59.02  E-value: 1.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   6 SKPTALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLIAERWP--ETA 83
Cdd:COG3437    5 QAPTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAP-PDLILLDVRMPG-MDGFELLRLLRADPStrDIP 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 947860480  84 VMVCSGP--LAFRPRTLPDKA-RFFPKPFSLNEVSA 116
Cdd:COG3437   83 VIFLTALadPEDRERALEAGAdDYLTKPFDPEELLA 118
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 11-121 7.60e-11

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 55.11  E-value: 7.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIE-AWTGDMALHLLGRLPtIQLVFTDVRMPGRVDGIRLAQLIAERWPeTAVMVCSg 89
Cdd:cd17534    4 LIVEDEAIIALDLKEILESLGYEVVGiADSGEEAIELAEENK-PDLILMDINLKGDMDGIEAAREIREKFD-IPVIFLT- 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 947860480  90 plAF-RPRTLpDKAR------FFPKPFSLNEVSAT-ALAL 121
Cdd:cd17534   81 --AYsDEETL-ERAKetnpygYLVKPFNERELKAAiELAL 117
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 7-123 1.18e-10

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 55.69  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   7 KPTALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLI--AERWPETAV 84
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHR-PDLILLDLEMPD-MDGLELCRRLraDPRTADIPI 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 947860480  85 MVCSGplafrPRTLPDKAR--------FFPKPFSLNEVSAtALALVA 123
Cdd:COG3706   79 IFLTA-----LDDEEDRARaleagaddYLTKPFDPEELLA-RVDLVA 119
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 9-109 1.26e-10

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 54.05  E-value: 1.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   9 TALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPTIQLVFTDVRMPgRVDGIRLAQLIAERWPETAVMVCS 88
Cdd:cd18160    1 TILLADDEPSVRKFIVTTLKKAGYAVTEAESGAEALEKLQQGKDIDIVVTDIVMP-EMDGIELAREARKIDPDVKILFIS 79

                         90       100
                 ....*....|....*....|....
gi 947860480  89 GPLAFRPRTLPD---KARFFPKPF 109
Cdd:cd18160   80 GGAAAAPELLSDavgDNATLKKPF 103
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 8-89 4.21e-10

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 52.97  E-value: 4.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   8 PTALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLgRLPTIQLVFTDVRMPGrVDGIRLAQLIAERWPETAVMVC 87
Cdd:cd17555    1 ATILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELF-RSEQPDLVLCDLRMPE-MDGLEVLKQITKESPDTPVIVV 78


                 ..
gi 947860480  88 SG 89
Cdd:cd17555   79 SG 80
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 11-117 2.19e-09

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 51.26  E-value: 2.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVI-EAWTGDMALHLLGRLPTiQLVFTDVRMPgRVDGIRLAQLIAERWPETAVMVCsg 89
Cdd:cd19932    4 LIAEDEALIRMDLREMLEEAGYEVVgEASDGEEAVELAKKHKP-DLVIMDVKMP-RLDGIEAAKIITSENIAPIVLLT-- 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 947860480  90 plAFRPRTLPDKAR------FFPKPFSLNEVSAT 117
Cdd:cd19932   80 --AYSQQDLVERAKeagamaYLVKPFSESDLIPA 111
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 11-89 9.37e-09

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 49.42  E-value: 9.37e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPTiQLVFTDVRMPGrVDGIRLAQLIAERWPETAVMVCSG 89
Cdd:cd17550    2 LIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRP-DLVLLDIWLPD-MDGLELLKEIKEKYPDLPVIMISG 78
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
9-114 1.34e-08

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 51.39  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   9 TALIVEDE-NITRMETMdVFADAGFDVIEAWTGDMALHLLGRLPTiQLVFTDVRMPgRVDGIRLAQLIAERWPETAV--M 85
Cdd:PRK11361   6 RILIVDDEdNVRRMLST-AFALQGFETHCANNGRTALHLFADIHP-DVVLMDIRMP-EMDGIKALKEMRSHETRTPVilM 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 947860480  86 VCSGPLAFRPRTLPDKA-RFFPKPFSLNEV 114
Cdd:PRK11361  83 TAYAEVETAVEALRCGAfDYVIKPFDLDEL 112
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 8-89 2.37e-08

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 48.90  E-value: 2.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   8 PTALIVEDEnITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGRVdGIRLAQLIAERWPETAVMVC 87
Cdd:cd17596    1 PTILVVDDE-VRSLEALRRTLEEDFDVLTAASAEEALAILEEEW-VQVILCDQRMPGTT-GVEFLKEVRERWPEVVRIII 77


                 ..
gi 947860480  88 SG 89
Cdd:cd17596   78 SG 79
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 9-77 4.94e-08

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 47.68  E-value: 4.94e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 947860480   9 TALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGrLPTIQLVFTDVRMPgRVDGIrlaQLIAE 77
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRGAGYEVVEAADGRDALSKAQ-SKKFDLIITDQNMP-NMDGI---ELIKE 65
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 8-89 5.89e-08

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 47.40  E-value: 5.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   8 PTALIVEDE-NI----TRmetmdVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLIAERWPET 82
Cdd:cd17569    1 PTILLVDDEpNIlkalKR-----LLRREGYEVLTATSGEEALEILKQEP-VDVVISDQRMPG-MDGAELLKRVRERYPDT 73


                 ....*..
gi 947860480  83 AVMVCSG 89
Cdd:cd17569   74 VRILLTG 80
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 11-75 6.59e-08

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 47.08  E-value: 6.59e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLI 75
Cdd:cd17546    2 LVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEP-FDLVLMDLQMPV-MDGLEATRRI 64
PRK11173 PRK11173
two-component response regulator; Provisional
 8-89 6.63e-08

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 48.86  E-value: 6.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   8 PTALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLgRLPTIQLVFTDVRMPGRvDGIRLAQLIAERwPETAVMVC 87
Cdd:PRK11173   4 PHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQIL-SENDINLVIMDINLPGK-NGLLLARELREQ-ANVALMFL 80


                 ..
gi 947860480  88 SG 89
Cdd:PRK11173  81 TG 82
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 11-86 1.11e-07

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 46.74  E-value: 1.11e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 947860480  11 LIVEDENITRMETMDVFADA-GFDVI-EAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLIAERWPETAVMV 86
Cdd:cd17535    2 LIVDDHPLVREGLRRLLESEpDIEVVgEAADGEEALALLRELR-PDVVLMDLSMPG-MDGIEALRRLRRRYPDLKVIV 77
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 11-123 1.63e-07

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 46.50  E-value: 1.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480  11 LIVEDENITRMETMDVFAD-AGFDVI-EAWTGDMALHLLGRLPtIQLVFTDVRMPGRvDGIRLAQLIAERWPETAVMVCS 88
Cdd:COG4565    7 LIVEDDPMVAELLRRYLERlPGFEVVgVASSGEEALALLAEHR-PDLILLDIYLPDG-DGLELLRELRARGPDVDVIVIT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 947860480  89 GplAFRPRTLPDKAR-----FFPKPFSLNEVSATALALVA 123
Cdd:COG4565   85 A--ARDPETVREALRagvvdYLIKPFTFERLREALERYLE 122
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 11-85 2.42e-07

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 45.48  E-value: 2.42e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 947860480  11 LIVEDE-NITRMeTMDVFADAGFDVIEAWTGDMALHLLgRLPTIQLVFTDVRMPGrVDGIRLAQLIAERWPETAVM 85
Cdd:cd17574    1 LVVEDDeEIAEL-LSDYLEKEGYEVDTAADGEEALELA-REEQPDLIILDVMLPG-MDGFEVCRRLREKGSDIPII 73
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 11-63 3.84e-07

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 43.71  E-value: 3.84e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 947860480    11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMP 63
Cdd:smart00448   4 LVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEK-PDLILLDIMMP 55
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 11-75 6.56e-07

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 44.29  E-value: 6.56e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLpTIQLVFTDVRMPGrVDGIRLAQLI 75
Cdd:cd19927    2 LLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQY-IPDLIISDIIMPG-VDGYSLLGKL 64
PRK13557 PRK13557
histidine kinase; Provisional
 9-89 9.61e-07

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 46.20  E-value: 9.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   9 TALIVED-ENITRMETMdVFADAGFDVIEAWTGDMALHLLGRLPTIQLVFTDVRMPGRVDGIRLAQLIAERWPETAVMVC 87
Cdd:PRK13557 417 TILIVDDrPDVAELARM-ILEDFGYRTLVASNGREALEILDSHPEVDLLFTDLIMPGGMNGVMLAREARRRQPKIKVLLT 495


                 ..
gi 947860480  88 SG 89
Cdd:PRK13557 496 TG 497
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 10-80 1.01e-06

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 44.43  E-value: 1.01e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 947860480  10 ALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPTIQLVFTDVRMPGrVDGIRLAQLIAERWP 80
Cdd:cd17544    3 VLVVDDSATSRNHLRALLRRHNFQVLEAANGQEALEVLEQHPDIKLVITDYNMPE-MDGFELVREIRKKYS 72
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 8-78 1.08e-06

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 43.91  E-value: 1.08e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 947860480   8 PTALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLIAER 78
Cdd:cd17619    1 PHILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQD-IDLVLLDINLPG-KDGLSLTRELREQ 69
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 9-86 1.56e-06

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 44.95  E-value: 1.56e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 947860480   9 TALIVEDENITRMETMDVFADAGFDVI-EAWTGDMALHLLGRLPTiQLVFTDVRMPGRvDGIRLAQLIAERWPETAVMV 86
Cdd:COG3707    5 RVLVVDDEPLRRADLREGLREAGYEVVaEAADGEDAVELVRELKP-DLVIVDIDMPDR-DGLEAARQISEERPAPVILL 81
PRK10766 PRK10766
two-component system response regulator TorR;
11-78 1.89e-06

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 44.64  E-value: 1.89e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLIAER 78
Cdd:PRK10766   6 LVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQH-VDLILLDINLPG-EDGLMLTRELRSR 71
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 10-75 3.22e-06

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 42.75  E-value: 3.22e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 947860480  10 ALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLP--------TIQLVFTDVRMPgRVDGIRLAQLI 75
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEALNKLENLAkegndlskELDLIITDIEMP-KMDGYELTFEL 73
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 8-122 4.95e-06

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 42.26  E-value: 4.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   8 PTALIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRlPTIQLVFTDVRMPGrVDGIRLAQLIAERWPETAVMVC 87
Cdd:cd19919    1 KTVWIVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALAS-SQPDVLISDIRMPG-MDGLALLAQIKQRHPDLPVIIM 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 947860480  88 -------SGPLAFRprtlpdKARF--FPKPFSLNEvsatALALV 122
Cdd:cd19919   79 tahsdldSAVSAYQ------GGAFeyLPKPFDIDE----AVALV 112
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 11-88 7.30e-06

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 41.85  E-value: 7.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480  11 LIVEDEN-ITRMETMDVFADAGFDVI-EAWTGDMALHLLGRLPtIQLVFTDVRMPGRvDGIRLAQLIAERWPETAVMVCS 88
Cdd:cd19925    4 LIVEDDPmVAEIHRAYVEQVPGFTVIgTAGTGEEALKLLKERQ-PDLILLDIYLPDG-NGLDLLRELRAAGHDVDVIVVT 81
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 11-75 9.30e-06

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 41.80  E-value: 9.30e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 947860480  11 LIVEDENITRMETMDVFADA-GFDVI-EAWTGDMALHLLGRLPtIQLVFTDVRMPGRvDGIRLAQLI 75
Cdd:COG2197    5 LIVDDHPLVREGLRALLEAEpDIEVVgEAADGEEALELLEELR-PDVVLLDIRMPGM-DGLEALRRL 69
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
11-77 2.04e-05

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 42.27  E-value: 2.04e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPgRVDGIRLAQLIAE 77
Cdd:PRK10841 805 LVVDDHPINRRLLADQLGSLGYQCKTANDGVDALNVLSKNH-IDIVLTDVNMP-NMDGYRLTQRLRQ 869
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 9-84 2.70e-05

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 41.73  E-value: 2.70e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 947860480   9 TALIVEDENITRMETMDVFAD-AGFDVI-EAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLIAERWPETAV 84
Cdd:COG3279    3 KILIVDDEPLARERLERLLEKyPDLEVVgEASNGEEALELLEEHK-PDLVFLDIQMPG-LDGFELARQLRELDPPPPI 78
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 11-83 3.96e-05

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 39.83  E-value: 3.96e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 947860480  11 LIVEDeNITRMETM-DVFADAGFDVIEAWTGDMALHLLgRLPTIQLVFTDVRMPGrVDGIRLAQLIAERwPETA 83
Cdd:cd17548    3 LIVED-NPLNMKLArDLLESAGYEVLEAADGEEALEIA-RKEKPDLILMDIQLPG-MDGLEATRLLKED-PATR 72
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 11-122 5.16e-05

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 39.51  E-value: 5.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGRvDGIRLAQLIAERWPETAVMVCS-- 88
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLEYALSGI-YDLIILDIMLPGM-DGLEVLKSLREEGIETPVLLLTal 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 947860480  89 GPLAFRPRTLPDKAR-FFPKPFSLNEVSATALALV 122
Cdd:cd17625   79 DAVEDRVKGLDLGADdYLPKPFSLAELLARIRALL 113
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 11-92 6.76e-05

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 39.40  E-value: 6.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPTIqLVFTDVRMPGrVDGIRLAQLIAERWPETAVMVCSG- 89
Cdd:cd17549    2 LLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFPG-VVISDIRMPG-MDGLELLAQIRELDPDLPVILITGh 79


                 ....*.
gi 947860480  90 ---PLA 92
Cdd:cd17549   80 gdvPMA 85
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 10-78 1.66e-04

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 38.29  E-value: 1.66e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 947860480  10 ALIVEDENITRMETMDVFA-DAGFDVI-EAWTGDMALHLLGRLPtIQLVFTDVRMPGrVDGIRLAQLIAER 78
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEeHPDIEIVgEAENGEEALEAIEELK-PDVVFLDIQMPG-LDGLELAKKLSKL 69
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
 8-117 1.92e-04

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 38.00  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   8 PTALIVEDENITRMETMDVFADAGFDVI-EAWTGDMALHLLGRLpTIQLVFTDVRMPGRVDGIRLAQLIAERWPETAVMV 86
Cdd:cd17540    1 TRVLIIEDEPLIAMDLEQIVEDLGHQVVgIARTRDEAVALARRE-RPDLILADIQLADGSSGIDAVNEILTTHDVPVIFV 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 947860480  87 CSGPLAFRPRTLPDKARFFPKPFSLNEVSAT 117
Cdd:cd17540   80 TAYPERLLTGERPEPTFLITKPFDPEMVKAA 110
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 11-116 1.95e-04

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 38.30  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPTiQLVFTDVRMPGrVDGIRLAQLIAERWPETAV--MVCS 88
Cdd:cd17553    4 LIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERP-DLVLLDMKIPG-MDGIEILKRMKVIDENIRViiMTAY 81

                         90       100
                 ....*....|....*....|....*....
gi 947860480  89 GPLAFRPRTLPDKA-RFFPKPFSLNEVSA 116
Cdd:cd17553   82 GELDMIQESKELGAlTHFAKPFDIDEIRD 110
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 8-88 2.29e-04

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 38.03  E-value: 2.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   8 PTALIVEDENITRMETMDVFADAGFDVI-EAWTGDMALHLLGRLpTIQLVFTDVRMPGrVDGIRLAQLIAERWPETAVMV 86
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKAGYEVVgEAANGEEAVEKYKEL-KPDLVTMDITMPE-MDGIEALKEIKKIDPNAKVIM 78


                 ..
gi 947860480  87 CS 88
Cdd:cd17542   79 CS 80
PRK13435 PRK13435
response regulator; Provisional
 7-123 4.75e-04

response regulator; Provisional


Pssm-ID: 184052 [Multi-domain]  Cd Length: 145  Bit Score: 37.34  E-value: 4.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   7 KPTALIVEDENITRMETMDVFADAGFDVI-EAWTGDMALHlLGRLPTIQLVFTDVRMPGRVDGIRLAQLIAERWPETAVM 85
Cdd:PRK13435   5 QLKVLIVEDEALIALELEKLVEEAGHEVVgIAMSSEQAIA-LGRRRQPDVALVDVHLADGPTGVEVARRLSADGGVEVVF 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 947860480  86 VcSGPLAFRPRTLPDKARFFPKPFSLNeVSATALALVA 123
Cdd:PRK13435  84 M-TGNPERVPHDFAGALGVIAKPYSPR-GVARALSYLS 119
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 11-85 8.48e-04

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 35.88  E-value: 8.48e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGRvDGIRLAQLIAERWPETAVM 85
Cdd:cd19935    2 LVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNE-YDLIILDVMLPGL-DGLEVLRRLRAAGKQTPVL 74
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 12-122 2.46e-03

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 36.39  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480  12 IVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRlPTIQLVFTDVRMPGrVDGIRLAQLIAERWPETAV--MVCSG 89
Cdd:PRK10923   8 VVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALAS-KTPDVLLSDIRMPG-MDGLALLKQIKQRHPMLPViiMTAHS 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 947860480  90 PLAFRPRTLPDKA-RFFPKPFSLNEvsatALALV 122
Cdd:PRK10923  86 DLDAAVSAYQQGAfDYLPKPFDIDE----AVALV 115
PRK15347 PRK15347
two component system sensor kinase;
11-74 3.50e-03

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 35.77  E-value: 3.50e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALhLLGRLPTIQLVFTDVRMPGrVDGIRLAQL 74
Cdd:PRK15347 694 LLVDDVETNRDIIGMMLVELGQQVTTAASGTEAL-ELGRQHRFDLVLMDIRMPG-LDGLETTQL 755
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 8-75 7.41e-03

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 33.76  E-value: 7.41e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480   8 PTALIVEDENITRmeTMDVFA--DAGFDVIEAWTGDMALHLLgRLPTIQLVFTDVRMPGRVdGIRLAQLI 75
Cdd:cd17618    1 RTILIVEDEPAIR--EMIAFNleRAGFDVVEAEDAESAVNLI-VEPRPDLILLDWMLPGGS-GIQFIRRL 66
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
 11-91 8.00e-03

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 33.91  E-value: 8.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 947860480  11 LIVEDENITRMETMDVFADAGFDVIEAWTGDMALHLLGRLPT-IQLVFTDVRMPGrVDGIRLAQLIAERWPEtavmvCSG 89
Cdd:cd19933    4 LLVDDNAVNRMVTKGLLEKLGCEVTTVSSGEECLNLLASAEHsFQLVLLDLCMPE-MDGFEVALRIRKLFGR-----RER 77


                 ..
gi 947860480  90 PL 91
Cdd:cd19933   78 PL 79
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 10-86 8.95e-03

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 33.28  E-value: 8.95e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 947860480  10 ALIVEDENITRmETMDV-FADAGFDVIEAWTGDMALHLLGRLPtIQLVFTDVRMPGRvDGIRLAQLIAERWPETAVMV 86
Cdd:cd19926    1 VLVVDDEPDIR-ELLEItLGRMGLDVRSARNVKEARELLASEP-YDLCLTDMRLPDG-SGLELVQHIQQRLPQTPVAV 75
PRK11697 PRK11697
two-component system response regulator BtsR;
9-71 9.27e-03

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 34.44  E-value: 9.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 947860480   9 TALIVEDENITRMETMDVFADAG-FDVI-EAWTGDMALHLLGRL-PtiQLVFTDVRMPgRVDGIRL 71
Cdd:PRK11697   3 KVLIVDDEPLAREELRELLQEEGdIEIVgECSNAIEAIGAIHRLkP--DVVFLDIQMP-RISGLEL 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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