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Conserved domains on  [gi|942030799|ref|WP_055270715|]
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MULTISPECIES: metal-dependent transcriptional regulator [Clostridia]

Protein Classification

metal-dependent transcriptional regulator( domain architecture ID 11442477)

metal-dependent transcriptional regulator may be activated by one or more from a variety of metal ions such as Mn, Cd, Co, Ni, and Fe, among others, and may function as an activator or repressor of gene expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-116 1.73e-38

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


:

Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 126.09  E-value: 1.73e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942030799   1 MKIHASGEDYLEAVLVLQKNHGAVRSIDVARRVGVSKASVSYAVSALREGGFLTVDSDYVLHLTETGRNVAEKIYERHQ- 79
Cdd:COG1321    2 MMLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRl 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 942030799  80 ---FFTEQFiaaGVDPEIAERDACRIEHAISQDTFEKIRD 116
Cdd:COG1321   82 lerFLVEVL---GVDWDEAHEEAERLEHVLSDETIERLDA 118
 
Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-116 1.73e-38

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 126.09  E-value: 1.73e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942030799   1 MKIHASGEDYLEAVLVLQKNHGAVRSIDVARRVGVSKASVSYAVSALREGGFLTVDSDYVLHLTETGRNVAEKIYERHQ- 79
Cdd:COG1321    2 MMLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRl 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 942030799  80 ---FFTEQFiaaGVDPEIAERDACRIEHAISQDTFEKIRD 116
Cdd:COG1321   82 lerFLVEVL---GVDWDEAHEEAERLEHVLSDETIERLDA 118
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 27-116 1.71e-17

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 71.48  E-value: 1.71e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942030799    27 IDVARRVGVSKASVSYAVSALREGGFLTVDSDYVLHLTETGRNVAEKIYERHQ----FFTEqfiAAGVDPEIAERDACRI 102
Cdd:smart00529   2 SEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRllerFLVD---VLGVDEEEVHEEAERL 78

                           90
                   ....*....|....
gi 942030799   103 EHAISQDTFEKIRD 116
Cdd:smart00529  79 EHVLSDELEDRLDR 92
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
8-116 3.34e-17

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 72.35  E-value: 3.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942030799   8 EDYLEAVLVLQKNHGAVRSIDVARRVGVSKASVSYAVSALREGGFLTVDSDYVLHLTETGRNVAEKIYERHQFFTEQFIA 87
Cdd:PRK11050  36 EDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVFLTPEGEKLAQESRERHQIVENFLLA 115

                         90       100
                 ....*....|....*....|....*....
gi 942030799  88 AGVDPEIAERDACRIEHAISQDTFEKIRD 116
Cdd:PRK11050 116 LGVSPETARRDAEGIEHHVSEETLAAFRR 144
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 64-116 3.87e-12

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 57.10  E-value: 3.87e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 942030799   64 TETGRNVAEKIYERHQ----FFTEQFiaaGVDPEIAERDACRIEHAISQDTFEKIRD 116
Cdd:pfam02742   1 TEKGRKIALRVVRRHRllerFLVDVL---GVDWDEVHEEAERLEHALSDELIDRLDE 54
 
Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-116 1.73e-38

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 126.09  E-value: 1.73e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942030799   1 MKIHASGEDYLEAVLVLQKNHGAVRSIDVARRVGVSKASVSYAVSALREGGFLTVDSDYVLHLTETGRNVAEKIYERHQ- 79
Cdd:COG1321    2 MMLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRl 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 942030799  80 ---FFTEQFiaaGVDPEIAERDACRIEHAISQDTFEKIRD 116
Cdd:COG1321   82 lerFLVEVL---GVDWDEAHEEAERLEHVLSDETIERLDA 118
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 27-116 1.71e-17

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 71.48  E-value: 1.71e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942030799    27 IDVARRVGVSKASVSYAVSALREGGFLTVDSDYVLHLTETGRNVAEKIYERHQ----FFTEqfiAAGVDPEIAERDACRI 102
Cdd:smart00529   2 SEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRllerFLVD---VLGVDEEEVHEEAERL 78

                           90
                   ....*....|....
gi 942030799   103 EHAISQDTFEKIRD 116
Cdd:smart00529  79 EHVLSDELEDRLDR 92
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
8-116 3.34e-17

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 72.35  E-value: 3.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942030799   8 EDYLEAVLVLQKNHGAVRSIDVARRVGVSKASVSYAVSALREGGFLTVDSDYVLHLTETGRNVAEKIYERHQFFTEQFIA 87
Cdd:PRK11050  36 EDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVFLTPEGEKLAQESRERHQIVENFLLA 115

                         90       100
                 ....*....|....*....|....*....
gi 942030799  88 AGVDPEIAERDACRIEHAISQDTFEKIRD 116
Cdd:PRK11050 116 LGVSPETARRDAEGIEHHVSEETLAAFRR 144
PRK03902 PRK03902
transcriptional regulator MntR;
6-116 5.26e-13

transcriptional regulator MntR;


Pssm-ID: 179669 [Multi-domain]  Cd Length: 142  Bit Score: 61.16  E-value: 5.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942030799   6 SGEDYLEAVLVLQKNHGAVRSIDVARRVGVSKASVSYAVSALREGGFLTVDSDYVLHLTETGRNVAEKIYERHQFFtEQF 85
Cdd:PRK03902   5 SMEDYIEQIYLLIEEKGYARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTPKGKKIGKRLVYRHELL-EQF 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 942030799  86 IAA-GVDPEIAERDACRIEHAISQDTFEKIRD 116
Cdd:PRK03902  84 LRIiGVDESKIYNDVEGIEHHLSWNAIDRIGD 115
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 64-116 3.87e-12

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 57.10  E-value: 3.87e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 942030799   64 TETGRNVAEKIYERHQ----FFTEQFiaaGVDPEIAERDACRIEHAISQDTFEKIRD 116
Cdd:pfam02742   1 TEKGRKIALRVVRRHRllerFLVDVL---GVDWDEVHEEAERLEHALSDELIDRLDE 54
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 5-53 1.13e-07

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 45.06  E-value: 1.13e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 942030799    5 ASGEDYLEAVLVLQKNHGAVRSIDVARRVGVSKASVSYAVSALREGGFL 53
Cdd:pfam01325   1 ESTEDYLETIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYV 49
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
14-87 6.15e-07

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 44.51  E-value: 6.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942030799    14 VLVLQKNHGAVRSIDVARRVGVSKASVSYAVSALREGGFLTVDSD------YVLHLTETGRNVAEKIYERHQFFTEQFIA 87
Cdd:smart00347  15 VLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSpedrrsVLVSLTEEGRELIEQLLEARSETLAELLA 94
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
14-117 1.04e-06

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 44.58  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942030799  14 VLVLQKNHGAVRSIDVARRVGVSKASVSYAVSALREGGFLTVDSD------YVLHLTETGRNVAEKIYERHQFFTEQfIA 87
Cdd:COG1846   43 VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDpedrraVLVRLTEKGRALLEEARPALEALLAE-LL 121

                         90       100       110
                 ....*....|....*....|....*....|
gi 942030799  88 AGVDPEiaERDACRiehaisqDTFEKIRDA 117
Cdd:COG1846  122 AGLSEE--ELEALL-------RLLRRLAEN 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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