|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09263 |
PRK09263 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
1-719 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236436 [Multi-domain] Cd Length: 711 Bit Score: 1099.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 1 MKIIKRNGSEETFDIQKIVVAVTKADKDNGE--RTLTDSQIEDIAEYVEFKCNklnraVSVEEIQDMVENQIMATGAFEL 78
Cdd:PRK09263 3 PKVIKRDGRKVPFDSEKIKNAIEKAAKAVEVddEDYCATVAAEIASRVEGRDE-----VDIEEIQDAVENQLMAGPYKAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 79 ARKYVRYRYKRSLVRKANTT-DNRILSLIEYNNEDVKQENSNKNPAVNSVQRDYMAGEVSRDLTTRMLLPHDIVEADREG 157
Cdd:PRK09263 78 ARAYIEYRHDRDIAREKATDlNEEIRGLIEQSNEAVLNENANKDSKVFSTQRDLLAGIVSKHYALRHLLPRDVVNAHEKG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 158 IIHFHDSDYYA-QHMHNCDLVNLEDMLQNGTVISGTMIEKPHSFSTACNIATQIIAQVASNQYGGQSISLA--HLAPFVD 234
Cdd:PRK09263 158 DIHYHDLDYSPfFPMFNCCLIDLKGMLTNGFKIGNAEIESPKSIQTATAVTAQIIAQVASSQYGGCTINRIdeVLAPYAE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 235 VSREKIRKEVISEQElvgmeypEDVLNEIVERRLKKEITKGVQTIEYQVITLMTTNGQAPFLTVFMYLNEAKNEREkkdl 314
Cdd:PRK09263 238 KSYEKHLKDAEEWVI-------EEKAEAYARARTEKEIYDAMQSLEYEINTLHTSNGQTPFVTLGFGLGTSWESRL---- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 315 amIIEETLRQRYQGVKNEAGvwvTPAFPKLIYVLEED-NIEEGSEYYYLTELAAKCTAKRLVPDYISEKKMKELkEGNCF 393
Cdd:PRK09263 307 --IQKAILRNRIAGLGKERK---TAIFPKLVFAIKDGlNLKPGDPNYDIKQLALECATKRMYPDILNYDKIVEL-TGSFK 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 394 PVMGCRSCLSPWKDENGNYKFYGRFNQGVVTINLVDVALSSGGDMDKFWKIFDDRLELCYRALMCRHNRLKGTLSDAAPI 473
Cdd:PRK09263 381 TPMGCRSFLQGWKDENGEEVHDGRNNLGVVTLNLPRIALEAKGDEDKFWEILDERLELAKKALMTRIERLKGAKPRVAPI 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 474 LWQFGALA-RLKKGEPIDKLLYGGYSTISLGYAGLYECVKYMTGKSHT-DPDATPFALDVMKHMNDACNQWKEETNVAFS 551
Cdd:PRK09263 461 LYMYGAFGvRLKADDDVDELFKNGRATISLGYIGLYETINALYGGSWEvNPEAKAFALAIVKRMKDACDQWKKETGYGFS 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 552 IYGSPIESTTYKFAKCLQKRFGIVPGITDKSYITNSYHVFVREEIDAFSKLKFESQFQALSSGGAISYVEVPDMKDNIAA 631
Cdd:PRK09263 541 LYSTPSESLTDRFCRLDTEKFGVIPGITDKGYYTNSFHYDVRKKVNPFEKLDFEKPYPPLASGGFIHYCEYPNLQHNLKA 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 632 VLQVIRFIYDNIMYAELNTKSDYCQECGYDGEIQIitDEEGklvWECPHCGNRNQDTLNVARRTCGYIGTQ---FWNQGR 708
Cdd:PRK09263 621 LEAVWDYSYDRVGYLGTNTPIDECYECGFTGEFEC--TEKG---FTCPKCGNHDPKTVSVTRRTCGYLGNPdarPFNHGR 695
|
730
....*....|.
gi 941714306 709 TQEIKERVLHL 719
Cdd:PRK09263 696 QEEIKRRVKHM 706
|
|
| NrdD |
COG1328 |
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ... |
1-708 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain] Cd Length: 671 Bit Score: 806.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 1 MKIIKRNGSEETFDIQKIVVAVTKADKDNGERTLTDSQIEDIAEYVEFKCNKLN--RAVSVEEIQDMVENQIMATGAFEL 78
Cdd:COG1328 3 LKVIKRDGRVVPFDPEKIANAIKKAAKAVGGEDRDEELAEEIADEVEKELERLGggGTITVEEIQDIVEKVLMESGHPEV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 79 ARKYVRYRYKRSLVRKANTTDNRILSLIEYNNEDVKQENSNKnPAVNSVQRDYMAGEVSRDLTTRMLLPHDIVEADREGI 158
Cdd:COG1328 83 AKAYILYREQRTRLREARTTLVDDIELLDEYDDWRVNENANK-SYSFSTQRDLIAGEVSKEYALNKILPPEVADAHRNGD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 159 IHFHDSDYYAQhMHNCDLVNLEDMLQNGTVISGTMIEKPHSFSTACNIATQIIAQVASNQYGGQSIS--LAHLAPFVDVs 236
Cdd:COG1328 162 IHIHDLDYLPR-MTNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSrfDTYLAPYVRK- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 237 rekirkeviseqelvgmeypedvlnEIVERRLKKEITKGVQTIEYQVITLMTTNGQAPFLTVFMYLNEAKNEreKKDLAM 316
Cdd:COG1328 240 -------------------------DKLEGKTYKEIKQAMQSLEYNLNTLPSRRGQTPFTSITFGLGTPEDF--SWEMRM 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 317 IIEETLRQRYQGVKNEAgvwvTPAFPKLIYVLEED-NIEEGSEYYYLTELAAKCTAKRLVPDYISEKKMKELKEGNCFPV 395
Cdd:COG1328 293 INKAILEVRIEGDGEGR----TFIFPKLIFNITEGfNWEPEDPNYDLLQLAFECTAKRGYPYFLNYDNSDELYKGSFKRS 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 396 MGCRSCLSPWkdENGNYKFYGRFNQGVVTINLVDVALSSGGDMDKFWKIFDDRLELCYRALMCRHNRLKG-TLSDAAPIL 474
Cdd:COG1328 369 MGCRLFLDGW--ENGEELNRGRGNLGVVTLNLPRIAYEAKGDEEKFFEILDERLDLAKEALEIKRKRLQKlAKAGLAPIL 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 475 WQFGA-LARLKKGEPIDKLLYGGYSTIslGYAGLYECVKYMTGKSH-TDPDATPFALDVMKHMNDACNQWKEETNVAFSI 552
Cdd:COG1328 447 YQTGAyLGRLKPDDSIDELFKNGFSTI--GYIGLNEMLLNFTGKHHiESEEAKAFALEILKHMRERADEWQEETGYLYSL 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 553 YGSPIESTTYKFAKCLQKRFGIVPGITDKSYITNSYHVFVREEIDAFSKLKFESQFQALSSGGAISYVEVPDMKDNIAAV 632
Cdd:COG1328 525 YATPAESLTYRFAKLDKKRFGDIIGVTDKPYYTNSFHLPVRKTIDPFEKLDFEDEYQPLYTGGTISYVELGELQPNPEAL 604
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 941714306 633 LQVIRFIYDN--IMYAELNTKSDYCQECGYDGEIQIitdeegklvwECPHCGNRnqDTLNVARRTCGYIG-TQFWNQGR 708
Cdd:COG1328 605 EAVVRYAYDNyrIGYLGINPPFDICPKCGYLGGEHD----------ECPKCGNE--DTVEVIRRTCGYLGnVQPWNDGK 671
|
|
| NRDD |
pfam13597 |
Anaerobic ribonucleoside-triphosphate reductase; |
117-718 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain] Cd Length: 554 Bit Score: 727.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 117 NSNKNPAVNSVQRDYMAGEVSRDLTTRMLLPHDIVEADREGIIHFHDSDYYAQHMHNCDLVNLEDMLQNGTVISGTMIEK 196
Cdd:pfam13597 1 NANKDSYSPSGQRLYIAGEVSKDYALRKLLPPEIADAHEEGDIHIHDLDYYALRTPYCCGIDLRDLLENGFVTGNGVSRP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 197 PHSFSTACNIATQIIAQVASNQYGGQSIS--LAHLAPFVDVSREKIRKEviseqelvgmeypedvlneiverRLKKEITK 274
Cdd:pfam13597 81 PKHIETACAQAVNILATVQNEQAGGQAFSsfDTYLAPFVRKDYEKHLKG-----------------------LTYKEVKQ 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 275 GVQTIEYQVITLMTTNG-QAPFLTVFMYLNEAKNEREKkdLAMIIEETLRQRYQGVKNEagvwVTPA-FPKLIYVLEED- 351
Cdd:pfam13597 138 AMQAFVYNLNTMPSRRGgQTPFTNINLGLDTPKEGRDE--MDMIIKALLEVMLEGDGNG----GTPFtFPIPIYKLKEGf 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 352 NIEEGSEYYYLTELAAKCTAKRLVPDYISEKKmkELKEGNCFPV-MGCRSCLSPWKDEngnYKFYG-RFNQGVVTINLVD 429
Cdd:pfam13597 212 NWDEGDPNYDLFELAFECTAKRGYPYFSNFDS--DLLPGDGYVAsMGCRLRLDLRPNR---KRFGGlRGNIGVVTINLPR 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 430 VALSSGGDMDKFWKIFDDRLELCYRALMCRHNRLKGTLSDA-APILWQFGALarlkkgepidkllYGGYSTISLGYAGLY 508
Cdd:pfam13597 287 IAYEAAGDEDKFFELLDERLELAKEALLIRREVLKKLLAKGlLPFLMGEGYL-------------RGGNHTLTIGFIGLN 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 509 ECVKYMTGKSHT-DPDATPFALDVMKHMNDACNQWKEETNVAFSIYGSPIESTTYKFAKCLQKRFGIVPGITDKSYITNS 587
Cdd:pfam13597 354 EALKALTGKHHGeSEEAKEFALKILKHMREKADEWKEETGLNFSLEATPAESLSYRFAKLDKKRFGEIKGVTDKPYYTNS 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 588 YHVFVREEIDAFSKLKFESQFQALSSGGAISYVEVPDMKDNIAAVLQVIRFIYD-NIMYAELNTKSDYCQECGYDGEIqi 666
Cdd:pfam13597 434 FHVPVDYTIDAFEKLKLEAPFQPLTTGGHISHVELGEAQPNPEALEKLVRIAYDtGIGYFSINPPIDVCPDCGYTGEI-- 511
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 941714306 667 itdeegklvWECPHCGNRNQDTlNVARRTCGYIG-TQFWNQGRTQEIKERVLH 718
Cdd:pfam13597 512 ---------EECPNCGNHDEKV-EVIRRITGYLRpVSDWNKGKQAELKDRVKH 554
|
|
| NrdD |
TIGR02487 |
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ... |
115-718 |
1.48e-145 |
|
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain] Cd Length: 579 Bit Score: 437.15 E-value: 1.48e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 115 QENSNKNPAVNSVQRDYMAGEVSRDLTTRMLLPHDIVEADREGIIHFHDSDYYAQHMHNCDLVNLEDMLQNGTVISGTMI 194
Cdd:TIGR02487 1 NENANMDSPTPSTQRKLIASEVSKDYALLHLLPKDIARAHLNGDIHIHDLDYALTLTTNCCLHDLRNLLKYGFRTGNIVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 195 EKPHSFSTACNIATQIIAQVASNQYGGQSIS--LAHLAPFVDVSREKIRKeviseqelVGMEYPEDV--LNEIVERRLKK 270
Cdd:TIGR02487 81 KPPKHIDVALNHIVNILQSLQNEQYGGQSFPefDTLLAPYIEKTNLKHRK--------VLQQLQLLLfeATEYAARRTFT 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 271 EITKGVQTIEYQVITLMTTNGQAPFLTVFMYLNEAKNERekkdlaMIIEETLRQRYQGVKNEAgvwvTPAFPKLIYVLEE 350
Cdd:TIGR02487 153 DVTQAMQGPEYNPNTLHSAGGQTPFESIGYGTETSKEGR------MIAKALLDVRMEGDGKGE----PFIFPKIIFKVRE 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 351 DNIEEGSEYYYLTELAAKCTAKRLVPDYISEKKMKELKEGNCFPvMGCRSCLSPWKDENGNYKFYGRFNQGVVTINLVDV 430
Cdd:TIGR02487 223 GFNWDEPDPYDLFELAFECAAKRGYPYFLNLDPEDNVKEDVRYP-MGCRTFLSPNENGDGEESYIGRGNIGVTSINLPRI 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 431 ALSSGGDMDKFWKIFDDRLELCYRALMCRHNRLKGTLSDAAPILWQFGalarLKKGEPIDKLLYGGY---STISLGYAGL 507
Cdd:TIGR02487 302 AYKSRGDEEEFFEELDEYLEIAKEALEIRREYLKKMLAKDLPPMYSQG----GWDGGNLLDESVEEIlksGTNSIGFIGL 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 508 YECVKYMTGKS-HTDPDATPFALDVMKHMNDACNQWKEETNVAFSIYGSPIESTTYKFAKCLQKRFGIVPGITDKSYITN 586
Cdd:TIGR02487 378 NEALVALTGKHlHEEEEARELAIRILEFIRDKADEFKKETGLNYSVYATPAESLCGRFAKKDREEFGEIPGVTDKPYYTN 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 587 SYHVFVREEIDAFSKLKFESQFQALSSGGAISYVEVPDMKDNIAAVLQVIRFIYDN-IMYAELNTKSDYCQECGYDGEIq 665
Cdd:TIGR02487 458 SFHVPVYEDVNLGEKIDIEAPFHPLTNGGHITYIELDEAIPDPEALKDITKKAMKNgIGYFGINPPVDVCEDCGYTGEG- 536
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 941714306 666 iitdeegkLVWECPHCGNRNqdtLNVARRTCGYIGT-QFWNQGRTQEIKERVLH 718
Cdd:TIGR02487 537 --------LNDKCPKCGSHD---IEVISRITGYLGPvENWNDGKQAEFKDRKKH 579
|
|
| RNR_III |
cd01675 |
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
116-700 |
4.77e-137 |
|
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain] Cd Length: 555 Bit Score: 414.39 E-value: 4.77e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 116 ENSNKNPAVNSVQRDYMAGEVSRDLTTRMLlPHDIVEADREGIIHFHDSDYYAQhMHNCDLVNLEDMLQNGTVISGTMIE 195
Cdd:cd01675 1 ENANVDSSPGSTMKDLAAGIVKKYYLLKIL-PKEIARAHLNGDIHIHDLDYLPL-TPYCCGWDLRPLLEKGFTTGNGIIE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 196 KPHSFSTACNIATQIIAQVASNQYGGQSIS--LAHLAPFVDVSREKIRKEviseqelvgmeypedvlneiverRLKKEIT 273
Cdd:cd01675 79 PPKHLSSALGHIVNFLGTVQNEQAGGQAFPefDTYLAPFVRKDYLKYRLT-----------------------ATRKEIK 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 274 KGVQTIEYQVITLMTTNGQAPFLTVFMYLNEAKNEREK-------------KDLAMIIEETLRQRYQGVKNEAgvwvTPA 340
Cdd:cd01675 136 QAMQGFIYNLNTLSRRGGQTPFTNITLGLVCPKDLEFEgggepvftygdtdKEARMIQKAFLEVRLEGDAKGR----PFT 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 341 FPKLIYVLEEDNIeeGSEYYYLTELAAKCTAKRLVPDYISEKKMKELKEGNCFpvMGCRSCLSPWK---DENGNYKFYGR 417
Cdd:cd01675 212 FPIPTFNVTEGFN--LDPNYDLKELAFECAAKRGYPYFLNFDNSDNVPGDVRA--MGCRLFLDKNElkrGGGLEGSGDGT 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 418 FNQGVVTINLVDVALSSGGDMDKFWKIFDDRLELCYRALMCRHNRLKGTLSDAAPILWQFGalarLKKGEPIDKLlygGY 497
Cdd:cd01675 288 GNIGVVTINLPRIAYEARGDEEKFFELLDEYLELAKDALEIRRKRLKEALARGLPPLYQEG----LGGGKLLFIL---KR 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 498 STISLGYAGLYECVKYMTGKSH-TDPDATPFALDVMKHMNDACNQWKEETNVAFSIYGSPIESTTYKFAKCLQKRFG-IV 575
Cdd:cd01675 361 HTLTIGFIGLNEAAEALTGKGIgESEEAREFGIRILEHIRERADEFKEETGLLYSVEATPAESLAYRFAKKDRKKYGdII 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 576 PGITDKSYITNSYHVFVREEIDAFSKLKFESQFQALSSGGAISYVEVPDMKDNIAAVLQVIRFIYDN-IMYAELNTKSDY 654
Cdd:cd01675 441 PGVTDKPYYTNSFHVPVYEDIDPFEKIDIEAKLHPLTTGGHILHIELGEAKPNPEALEALVKKAAKRgVIYFGINTPIDI 520
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 941714306 655 CQECGYDGEiqiitdeegKLVWECPHCGNRNqdtLNVARRTCGYIG 700
Cdd:cd01675 521 CNDCGYIGE---------GEGFKCPKCGSED---VEVISRITGYLG 554
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09263 |
PRK09263 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
1-719 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236436 [Multi-domain] Cd Length: 711 Bit Score: 1099.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 1 MKIIKRNGSEETFDIQKIVVAVTKADKDNGE--RTLTDSQIEDIAEYVEFKCNklnraVSVEEIQDMVENQIMATGAFEL 78
Cdd:PRK09263 3 PKVIKRDGRKVPFDSEKIKNAIEKAAKAVEVddEDYCATVAAEIASRVEGRDE-----VDIEEIQDAVENQLMAGPYKAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 79 ARKYVRYRYKRSLVRKANTT-DNRILSLIEYNNEDVKQENSNKNPAVNSVQRDYMAGEVSRDLTTRMLLPHDIVEADREG 157
Cdd:PRK09263 78 ARAYIEYRHDRDIAREKATDlNEEIRGLIEQSNEAVLNENANKDSKVFSTQRDLLAGIVSKHYALRHLLPRDVVNAHEKG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 158 IIHFHDSDYYA-QHMHNCDLVNLEDMLQNGTVISGTMIEKPHSFSTACNIATQIIAQVASNQYGGQSISLA--HLAPFVD 234
Cdd:PRK09263 158 DIHYHDLDYSPfFPMFNCCLIDLKGMLTNGFKIGNAEIESPKSIQTATAVTAQIIAQVASSQYGGCTINRIdeVLAPYAE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 235 VSREKIRKEVISEQElvgmeypEDVLNEIVERRLKKEITKGVQTIEYQVITLMTTNGQAPFLTVFMYLNEAKNEREkkdl 314
Cdd:PRK09263 238 KSYEKHLKDAEEWVI-------EEKAEAYARARTEKEIYDAMQSLEYEINTLHTSNGQTPFVTLGFGLGTSWESRL---- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 315 amIIEETLRQRYQGVKNEAGvwvTPAFPKLIYVLEED-NIEEGSEYYYLTELAAKCTAKRLVPDYISEKKMKELkEGNCF 393
Cdd:PRK09263 307 --IQKAILRNRIAGLGKERK---TAIFPKLVFAIKDGlNLKPGDPNYDIKQLALECATKRMYPDILNYDKIVEL-TGSFK 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 394 PVMGCRSCLSPWKDENGNYKFYGRFNQGVVTINLVDVALSSGGDMDKFWKIFDDRLELCYRALMCRHNRLKGTLSDAAPI 473
Cdd:PRK09263 381 TPMGCRSFLQGWKDENGEEVHDGRNNLGVVTLNLPRIALEAKGDEDKFWEILDERLELAKKALMTRIERLKGAKPRVAPI 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 474 LWQFGALA-RLKKGEPIDKLLYGGYSTISLGYAGLYECVKYMTGKSHT-DPDATPFALDVMKHMNDACNQWKEETNVAFS 551
Cdd:PRK09263 461 LYMYGAFGvRLKADDDVDELFKNGRATISLGYIGLYETINALYGGSWEvNPEAKAFALAIVKRMKDACDQWKKETGYGFS 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 552 IYGSPIESTTYKFAKCLQKRFGIVPGITDKSYITNSYHVFVREEIDAFSKLKFESQFQALSSGGAISYVEVPDMKDNIAA 631
Cdd:PRK09263 541 LYSTPSESLTDRFCRLDTEKFGVIPGITDKGYYTNSFHYDVRKKVNPFEKLDFEKPYPPLASGGFIHYCEYPNLQHNLKA 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 632 VLQVIRFIYDNIMYAELNTKSDYCQECGYDGEIQIitDEEGklvWECPHCGNRNQDTLNVARRTCGYIGTQ---FWNQGR 708
Cdd:PRK09263 621 LEAVWDYSYDRVGYLGTNTPIDECYECGFTGEFEC--TEKG---FTCPKCGNHDPKTVSVTRRTCGYLGNPdarPFNHGR 695
|
730
....*....|.
gi 941714306 709 TQEIKERVLHL 719
Cdd:PRK09263 696 QEEIKRRVKHM 706
|
|
| NrdD |
COG1328 |
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ... |
1-708 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain] Cd Length: 671 Bit Score: 806.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 1 MKIIKRNGSEETFDIQKIVVAVTKADKDNGERTLTDSQIEDIAEYVEFKCNKLN--RAVSVEEIQDMVENQIMATGAFEL 78
Cdd:COG1328 3 LKVIKRDGRVVPFDPEKIANAIKKAAKAVGGEDRDEELAEEIADEVEKELERLGggGTITVEEIQDIVEKVLMESGHPEV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 79 ARKYVRYRYKRSLVRKANTTDNRILSLIEYNNEDVKQENSNKnPAVNSVQRDYMAGEVSRDLTTRMLLPHDIVEADREGI 158
Cdd:COG1328 83 AKAYILYREQRTRLREARTTLVDDIELLDEYDDWRVNENANK-SYSFSTQRDLIAGEVSKEYALNKILPPEVADAHRNGD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 159 IHFHDSDYYAQhMHNCDLVNLEDMLQNGTVISGTMIEKPHSFSTACNIATQIIAQVASNQYGGQSIS--LAHLAPFVDVs 236
Cdd:COG1328 162 IHIHDLDYLPR-MTNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSrfDTYLAPYVRK- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 237 rekirkeviseqelvgmeypedvlnEIVERRLKKEITKGVQTIEYQVITLMTTNGQAPFLTVFMYLNEAKNEreKKDLAM 316
Cdd:COG1328 240 -------------------------DKLEGKTYKEIKQAMQSLEYNLNTLPSRRGQTPFTSITFGLGTPEDF--SWEMRM 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 317 IIEETLRQRYQGVKNEAgvwvTPAFPKLIYVLEED-NIEEGSEYYYLTELAAKCTAKRLVPDYISEKKMKELKEGNCFPV 395
Cdd:COG1328 293 INKAILEVRIEGDGEGR----TFIFPKLIFNITEGfNWEPEDPNYDLLQLAFECTAKRGYPYFLNYDNSDELYKGSFKRS 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 396 MGCRSCLSPWkdENGNYKFYGRFNQGVVTINLVDVALSSGGDMDKFWKIFDDRLELCYRALMCRHNRLKG-TLSDAAPIL 474
Cdd:COG1328 369 MGCRLFLDGW--ENGEELNRGRGNLGVVTLNLPRIAYEAKGDEEKFFEILDERLDLAKEALEIKRKRLQKlAKAGLAPIL 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 475 WQFGA-LARLKKGEPIDKLLYGGYSTIslGYAGLYECVKYMTGKSH-TDPDATPFALDVMKHMNDACNQWKEETNVAFSI 552
Cdd:COG1328 447 YQTGAyLGRLKPDDSIDELFKNGFSTI--GYIGLNEMLLNFTGKHHiESEEAKAFALEILKHMRERADEWQEETGYLYSL 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 553 YGSPIESTTYKFAKCLQKRFGIVPGITDKSYITNSYHVFVREEIDAFSKLKFESQFQALSSGGAISYVEVPDMKDNIAAV 632
Cdd:COG1328 525 YATPAESLTYRFAKLDKKRFGDIIGVTDKPYYTNSFHLPVRKTIDPFEKLDFEDEYQPLYTGGTISYVELGELQPNPEAL 604
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 941714306 633 LQVIRFIYDN--IMYAELNTKSDYCQECGYDGEIQIitdeegklvwECPHCGNRnqDTLNVARRTCGYIG-TQFWNQGR 708
Cdd:COG1328 605 EAVVRYAYDNyrIGYLGINPPFDICPKCGYLGGEHD----------ECPKCGNE--DTVEVIRRTCGYLGnVQPWNDGK 671
|
|
| NRDD |
pfam13597 |
Anaerobic ribonucleoside-triphosphate reductase; |
117-718 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain] Cd Length: 554 Bit Score: 727.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 117 NSNKNPAVNSVQRDYMAGEVSRDLTTRMLLPHDIVEADREGIIHFHDSDYYAQHMHNCDLVNLEDMLQNGTVISGTMIEK 196
Cdd:pfam13597 1 NANKDSYSPSGQRLYIAGEVSKDYALRKLLPPEIADAHEEGDIHIHDLDYYALRTPYCCGIDLRDLLENGFVTGNGVSRP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 197 PHSFSTACNIATQIIAQVASNQYGGQSIS--LAHLAPFVDVSREKIRKEviseqelvgmeypedvlneiverRLKKEITK 274
Cdd:pfam13597 81 PKHIETACAQAVNILATVQNEQAGGQAFSsfDTYLAPFVRKDYEKHLKG-----------------------LTYKEVKQ 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 275 GVQTIEYQVITLMTTNG-QAPFLTVFMYLNEAKNEREKkdLAMIIEETLRQRYQGVKNEagvwVTPA-FPKLIYVLEED- 351
Cdd:pfam13597 138 AMQAFVYNLNTMPSRRGgQTPFTNINLGLDTPKEGRDE--MDMIIKALLEVMLEGDGNG----GTPFtFPIPIYKLKEGf 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 352 NIEEGSEYYYLTELAAKCTAKRLVPDYISEKKmkELKEGNCFPV-MGCRSCLSPWKDEngnYKFYG-RFNQGVVTINLVD 429
Cdd:pfam13597 212 NWDEGDPNYDLFELAFECTAKRGYPYFSNFDS--DLLPGDGYVAsMGCRLRLDLRPNR---KRFGGlRGNIGVVTINLPR 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 430 VALSSGGDMDKFWKIFDDRLELCYRALMCRHNRLKGTLSDA-APILWQFGALarlkkgepidkllYGGYSTISLGYAGLY 508
Cdd:pfam13597 287 IAYEAAGDEDKFFELLDERLELAKEALLIRREVLKKLLAKGlLPFLMGEGYL-------------RGGNHTLTIGFIGLN 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 509 ECVKYMTGKSHT-DPDATPFALDVMKHMNDACNQWKEETNVAFSIYGSPIESTTYKFAKCLQKRFGIVPGITDKSYITNS 587
Cdd:pfam13597 354 EALKALTGKHHGeSEEAKEFALKILKHMREKADEWKEETGLNFSLEATPAESLSYRFAKLDKKRFGEIKGVTDKPYYTNS 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 588 YHVFVREEIDAFSKLKFESQFQALSSGGAISYVEVPDMKDNIAAVLQVIRFIYD-NIMYAELNTKSDYCQECGYDGEIqi 666
Cdd:pfam13597 434 FHVPVDYTIDAFEKLKLEAPFQPLTTGGHISHVELGEAQPNPEALEKLVRIAYDtGIGYFSINPPIDVCPDCGYTGEI-- 511
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 941714306 667 itdeegklvWECPHCGNRNQDTlNVARRTCGYIG-TQFWNQGRTQEIKERVLH 718
Cdd:pfam13597 512 ---------EECPNCGNHDEKV-EVIRRITGYLRpVSDWNKGKQAELKDRVKH 554
|
|
| NrdD |
TIGR02487 |
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ... |
115-718 |
1.48e-145 |
|
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain] Cd Length: 579 Bit Score: 437.15 E-value: 1.48e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 115 QENSNKNPAVNSVQRDYMAGEVSRDLTTRMLLPHDIVEADREGIIHFHDSDYYAQHMHNCDLVNLEDMLQNGTVISGTMI 194
Cdd:TIGR02487 1 NENANMDSPTPSTQRKLIASEVSKDYALLHLLPKDIARAHLNGDIHIHDLDYALTLTTNCCLHDLRNLLKYGFRTGNIVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 195 EKPHSFSTACNIATQIIAQVASNQYGGQSIS--LAHLAPFVDVSREKIRKeviseqelVGMEYPEDV--LNEIVERRLKK 270
Cdd:TIGR02487 81 KPPKHIDVALNHIVNILQSLQNEQYGGQSFPefDTLLAPYIEKTNLKHRK--------VLQQLQLLLfeATEYAARRTFT 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 271 EITKGVQTIEYQVITLMTTNGQAPFLTVFMYLNEAKNERekkdlaMIIEETLRQRYQGVKNEAgvwvTPAFPKLIYVLEE 350
Cdd:TIGR02487 153 DVTQAMQGPEYNPNTLHSAGGQTPFESIGYGTETSKEGR------MIAKALLDVRMEGDGKGE----PFIFPKIIFKVRE 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 351 DNIEEGSEYYYLTELAAKCTAKRLVPDYISEKKMKELKEGNCFPvMGCRSCLSPWKDENGNYKFYGRFNQGVVTINLVDV 430
Cdd:TIGR02487 223 GFNWDEPDPYDLFELAFECAAKRGYPYFLNLDPEDNVKEDVRYP-MGCRTFLSPNENGDGEESYIGRGNIGVTSINLPRI 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 431 ALSSGGDMDKFWKIFDDRLELCYRALMCRHNRLKGTLSDAAPILWQFGalarLKKGEPIDKLLYGGY---STISLGYAGL 507
Cdd:TIGR02487 302 AYKSRGDEEEFFEELDEYLEIAKEALEIRREYLKKMLAKDLPPMYSQG----GWDGGNLLDESVEEIlksGTNSIGFIGL 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 508 YECVKYMTGKS-HTDPDATPFALDVMKHMNDACNQWKEETNVAFSIYGSPIESTTYKFAKCLQKRFGIVPGITDKSYITN 586
Cdd:TIGR02487 378 NEALVALTGKHlHEEEEARELAIRILEFIRDKADEFKKETGLNYSVYATPAESLCGRFAKKDREEFGEIPGVTDKPYYTN 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 587 SYHVFVREEIDAFSKLKFESQFQALSSGGAISYVEVPDMKDNIAAVLQVIRFIYDN-IMYAELNTKSDYCQECGYDGEIq 665
Cdd:TIGR02487 458 SFHVPVYEDVNLGEKIDIEAPFHPLTNGGHITYIELDEAIPDPEALKDITKKAMKNgIGYFGINPPVDVCEDCGYTGEG- 536
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 941714306 666 iitdeegkLVWECPHCGNRNqdtLNVARRTCGYIGT-QFWNQGRTQEIKERVLH 718
Cdd:TIGR02487 537 --------LNDKCPKCGSHD---IEVISRITGYLGPvENWNDGKQAEFKDRKKH 579
|
|
| RNR_III |
cd01675 |
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
116-700 |
4.77e-137 |
|
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain] Cd Length: 555 Bit Score: 414.39 E-value: 4.77e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 116 ENSNKNPAVNSVQRDYMAGEVSRDLTTRMLlPHDIVEADREGIIHFHDSDYYAQhMHNCDLVNLEDMLQNGTVISGTMIE 195
Cdd:cd01675 1 ENANVDSSPGSTMKDLAAGIVKKYYLLKIL-PKEIARAHLNGDIHIHDLDYLPL-TPYCCGWDLRPLLEKGFTTGNGIIE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 196 KPHSFSTACNIATQIIAQVASNQYGGQSIS--LAHLAPFVDVSREKIRKEviseqelvgmeypedvlneiverRLKKEIT 273
Cdd:cd01675 79 PPKHLSSALGHIVNFLGTVQNEQAGGQAFPefDTYLAPFVRKDYLKYRLT-----------------------ATRKEIK 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 274 KGVQTIEYQVITLMTTNGQAPFLTVFMYLNEAKNEREK-------------KDLAMIIEETLRQRYQGVKNEAgvwvTPA 340
Cdd:cd01675 136 QAMQGFIYNLNTLSRRGGQTPFTNITLGLVCPKDLEFEgggepvftygdtdKEARMIQKAFLEVRLEGDAKGR----PFT 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 341 FPKLIYVLEEDNIeeGSEYYYLTELAAKCTAKRLVPDYISEKKMKELKEGNCFpvMGCRSCLSPWK---DENGNYKFYGR 417
Cdd:cd01675 212 FPIPTFNVTEGFN--LDPNYDLKELAFECAAKRGYPYFLNFDNSDNVPGDVRA--MGCRLFLDKNElkrGGGLEGSGDGT 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 418 FNQGVVTINLVDVALSSGGDMDKFWKIFDDRLELCYRALMCRHNRLKGTLSDAAPILWQFGalarLKKGEPIDKLlygGY 497
Cdd:cd01675 288 GNIGVVTINLPRIAYEARGDEEKFFELLDEYLELAKDALEIRRKRLKEALARGLPPLYQEG----LGGGKLLFIL---KR 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 498 STISLGYAGLYECVKYMTGKSH-TDPDATPFALDVMKHMNDACNQWKEETNVAFSIYGSPIESTTYKFAKCLQKRFG-IV 575
Cdd:cd01675 361 HTLTIGFIGLNEAAEALTGKGIgESEEAREFGIRILEHIRERADEFKEETGLLYSVEATPAESLAYRFAKKDRKKYGdII 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 576 PGITDKSYITNSYHVFVREEIDAFSKLKFESQFQALSSGGAISYVEVPDMKDNIAAVLQVIRFIYDN-IMYAELNTKSDY 654
Cdd:cd01675 441 PGVTDKPYYTNSFHVPVYEDIDPFEKIDIEAKLHPLTTGGHILHIELGEAKPNPEALEALVKKAAKRgVIYFGINTPIDI 520
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 941714306 655 CQECGYDGEiqiitdeegKLVWECPHCGNRNqdtLNVARRTCGYIG 700
Cdd:cd01675 521 CNDCGYIGE---------GEGFKCPKCGSED---VEVISRITGYLG 554
|
|
| PRK07111 |
PRK07111 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
2-719 |
1.21e-115 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 235937 [Multi-domain] Cd Length: 735 Bit Score: 364.66 E-value: 1.21e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 2 KIIKRNGSEETFDIQKIVVAVTKADKDNGERTLTDSQIEDIAEYVEFKCNKLNRAVSVEEIQDMVENQIMATGAFELARK 81
Cdd:PRK07111 4 YIVKRDGREVPFDEEKITNAIFKAAEAVGGELDESEAIELTQKVIKYLEEKYKEEVTVEDIQDLVEKVLIENGHAETAKA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 82 YVRYRYKRSLVRKANTtdnRILSLIEYNNEDVKQENSN---KNPAVNSVQrdyMAGEVSRDLTTRMLLPHDIVEADREGI 158
Cdd:PRK07111 84 YILYRAERTRIREIKS---DLMKAIEEIGNDTDRENANvsgNTPSGKMLR---IASESNKDYYNLYLLPKELAKAHENGD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 159 IHFHDSDYYAQHMhNCDLVNLEDMLQNGTVISGTMIEKPHSFSTACNIATqIIAQVASN-QYGGQSISL--AHLAPFVDV 235
Cdd:PRK07111 158 IHIHDLDFYNLTT-TCLQIDLKKLLERGFNTGHGYIREPKRIESAAALAC-IILQSNQNdMHGGQSIPNfdNDMAPFVEK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 236 SREKIRKEVIseQELVGMEYPEDV------------------------------LNEIVERRLKKEITkgvQTIEYQVIT 285
Cdd:PRK07111 236 TFRRHRKEIL--EKLLELGVGEEVdekeslneeeellllllaldfniakkaqekADELAEKETRKRTY---QAMEGFIHN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 286 LMTTNGQAPFLTVFMYLNEAKNEREkkDLAMIIEETLRQRYQGV-KNEagvwvTPAFPKLIYVLEED-NIEEGSEYYYLT 363
Cdd:PRK07111 311 LNTMHSRAGAQVPFSSINYGTDTSP--EGRMVCENLLLATEKGLgKGE-----TPIFPIQIFRVKEGvNYNEEDPNYDLF 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 364 ELAAKCTAKRLVPDYIS-----EKKMKELKEGNC-FPVMGCRSCLspWKDENGNYKFYGRFNQGVVTINLVDVALSSGGD 437
Cdd:PRK07111 384 KLACRVAAKRLFPNFSFldapfNKEYYDKGRPPTeVATMGCRTRV--MSNVNGEEGTKGRGNLSFTTINLPRLAIEAKKD 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 438 MDKFWKIFDDRLELCYRALMCRHNRLKGTLSDAAPI-----LWQFGAlaRLKKGEPIDKLLYGGysTISLGYAGLYECVK 512
Cdd:PRK07111 462 IDKFFELLDERLELAIEQLLHRYEVQKTLKVKDFPFlmgqgLWKGSE--NLGPDDSIEPVLKQG--TLGIGFIGLAETLV 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 513 YMTGKSH-TDPDATPFALDVMKHMNDACNQWKEETNVAFSIYGSPIESTTYKFAKCLQKRFGIVPGITDKSYITNSYHVF 591
Cdd:PRK07111 538 ALTGKHHgESEEAQELGLKIVSHMRDFCDEYKEEYKLNYSLLATPAEGLSGRFIKMDRKKFGEIKGVTDKEYYTNSFHVP 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 592 VREEIDAFSKLKFESQFQALSSGGAISYVEVP-DMKDNIAAVLQVIRFIYD-NIMYAELNTKSDYCQECGYDGeiqIITD 669
Cdd:PRK07111 618 VYYPISIFEKIEIEAPYHKLTNGGHISYVELDgDPSKNVEAFEIIVKAMKNtNIGYGSINHPVDRCPVCGYLG---VIED 694
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|.
gi 941714306 670 eegklvwECPHCGNRNQDTLnvaRRTCGYIGT-QFWNQGRTQEIKERVLHL 719
Cdd:PRK07111 695 -------KCPKCGSTNIQRI---RRITGYLGTlDRFNSAKKAERRDRVKHG 735
|
|
| PRK14704 |
PRK14704 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
105-719 |
1.19e-75 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 184798 [Multi-domain] Cd Length: 618 Bit Score: 255.88 E-value: 1.19e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 105 LIEYNNEDVKQENSNKNPAVNSVQRDYMAGEVSRDLTTRMLLPHDIVEADREGIIHFHDSDYYAQHMHNCDLVNLEDMLQ 184
Cdd:PRK14704 18 IVHGNEQDLMQENANVDGRSPMGVMGTFASESAKYYAVENLLSDQVKKAINENILYPHDLDFYATGTTTCSQIPLAQMLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 185 NGTVISGTMIEKPHSFSTACNIATqIIAQVASN-QYGGQSISL--AHLAPFVDVSRE----KIRKEVISEQElvgmeype 257
Cdd:PRK14704 98 NGFHTGHGHMRQPQDIKSALALSS-IIFQANQNmQHGGQSFALfdVDLAPYVRKTVErhkkRLQSYPLTKEQ-------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 258 dvlneIVERRLKKEITKGVQTIEYQVITLMTTN----GQAPFLTVFMYLNEAKNERekkdlaMIIEETLRQRYQGVKNEA 333
Cdd:PRK14704 169 -----IEEFAWKETENDTYQACEAFIHNSNSMHsrggGQVPFISINYGTDTSKEGR------LLIKQLLKATQAGLGKGE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 334 gvwvTPAFPKLIYVLEED-NIEEGSEYYYLTELAAKCTAKRLVPDY--ISEKKMKELKEGN-----CFpvMGCRSCLspW 405
Cdd:PRK14704 238 ----TPIFPIQIFKMKKGvNFEESDPNYDLFELALETTAERLFPNFsfLDAPFNAVHYDGRpesevCY--MGCRTRV--M 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 406 KDENGNYKFYGRFNQGVVTINLVDVALSSGgDMDKFWKIFDDRLELCYRALMCR-HNRLKGTLSDAAPI----LWQFGAl 480
Cdd:PRK14704 310 SNIHGEETAIGRGNLSFTSINLVKLALISG-SKEAFFEALNYYLDLGIKQLLERfEYQCTKRARDFRFLysqgVWRGGE- 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 481 aRLKKGEPIDKLLYGGysTISLGYAGLYECVKYMTGKSHTDPD-ATPFALDVMKHMNDACNQWKEETNVAFSIYGSPIES 559
Cdd:PRK14704 388 -KLQPEDSVASILKQG--TLSLGFIGLAECLVALTGKHHGEDEeSWKLGYEIISFMRDRMDKATEEHELNFSVIATPAEG 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 560 TTYKFAKCLQKRFGIVPGITDKSYITNSYHVFVREEIDAFSKLKFESQFQALSSGGAISYVEVP-DMKDNIAAVLQVIRF 638
Cdd:PRK14704 465 LSGKFVKKDREEFGVISGITNHNYYTNSFHIPVYYNIQAINKIRLEGPFHALCNGGHITYIELDgAAMHNKKALKQIVQA 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 639 IYDNIM-YAELNTKSDYCQECGYDGEIQIitdeegklvwECPHCGNRNQDTLNVARRTCGY-IGT-QFWNQGRTQEIKER 715
Cdd:PRK14704 545 MAEHGVgYGSINHPVDRCKCCSYHGVIGN----------ECPSCGNEDEANIERIRRITGYlVGDmSKWNSAKRSEEMDR 614
|
....
gi 941714306 716 VLHL 719
Cdd:PRK14704 615 VKHK 618
|
|
| PRK08270 |
PRK08270 |
ribonucleoside triphosphate reductase; |
1-682 |
2.34e-36 |
|
ribonucleoside triphosphate reductase;
Pssm-ID: 236212 [Multi-domain] Cd Length: 656 Bit Score: 145.76 E-value: 2.34e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 1 MKIIKRNGSEETFDIQKIVVAVTKADKDNGERTltDSQIEDIAEYVEFKCNKlNRAVSVEEIQDMVENQIMATGAFELAR 80
Cdd:PRK08270 3 TKIIKRDGRIVPFDAEKITEAIAKAFKATGEFD--PSEAERLALRVIEKLED-EDIPSVEEIQDIVEKVLIEAGYFKTAK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 81 KYVRYRYKRSLVRKANTTDNRILSLI-EY-NNED--VKqENSNKNpavNSVQ--RDYMAGEVSRDLTTRMLLPHDIVEAD 154
Cdd:PRK08270 80 AYILYREQHARLRNDKKTLLDVEDTVdEYlDREDwrVN-ENSNMG---YSLQglILNISGKVTANYWLNKVYPPEIGEAH 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 155 REGIIHFHDSDYYAQHmhnCDLVNLEDMLQNG-TVISGTMIEKP--HsFSTACNiatQII------------AQVASN-- 217
Cdd:PRK08270 156 RNGDLHIHDLDMLSGY---CAGWSLRDLLLEGfNGVPGKVESKPpkH-FRSALG---QIVnflgtlqnewagAQAFSSfd 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 218 QYggqsislahLAPFVdvsrekiRKEviseqelvGMEYpedvlneiverrlkKEITKGVQTIEYQVITLMTTNGQAPFLT 297
Cdd:PRK08270 229 TY---------LAPFV-------RKD--------GLSY--------------KEVKQAIQEFVFNLNVPSRWGFQTPFTN 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 298 VFMYLNEAKNEREKKdlAMIIEETLRQRYQGVK------NEAGVWVTPA---------FPKLIYVLEEDNIEEGSEYYYL 362
Cdd:PRK08270 271 LTFDLTVPEDLKDQP--VIIGGEEMDFTYGDFQkemdmiNRAFIEVMLEgdangrvftFPIPTYNITKDFDWDSENADLL 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 363 TELaakcTAKRLVP---DYISEkkmkELKEGNcfpV--MGCRscLSPWKDE-----NGnykFYGRFNQ----GVVTINLV 428
Cdd:PRK08270 349 FEM----TAKYGLPyfqNFINS----DLKPED---VrsMCCR--LQLDLRElrkrgGG---LFGSAELtgsiGVVTINLP 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 429 DVA-LSSggDMDKFWKIFDDRLELCYRALmcrhnrlkgtlsdaapilwqfgalarLKKGEPIDKLL----------YGGY 497
Cdd:PRK08270 413 RLGyLSK--DEEEFFARLDELMDLAKDSL--------------------------EIKRKVIERLTdkglypytkrYLGT 464
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 498 -----STIslGYAGLYECVKYMTGKSHTDPDATPFALDVMKHMNDACNQWKEETNVAFSIYGSPIESTTYKFAKCLQKRF 572
Cdd:PRK08270 465 lrnhfSTI--GLNGMNEACLNFLGKDITTEEGRAFALRVLDHMRERLVEFQEETGNLYNLEATPAEGTTYRLAKEDKKRY 542
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 573 G--IVPGITDKSYITNSYHVFVREEIDAFSKLKFESQFQALSSGGAI--SYV--EVPDmkdnIAAVLQVIRFIYDN--IM 644
Cdd:PRK08270 543 PdiITAGTDEEPYYTNSTQLPVGYTDDPFEALELQDELQTKYTGGTVfhLYLgeAISD----AEACKKLVKKALENyrLP 618
|
730 740 750
....*....|....*....|....*....|....*....
gi 941714306 645 YAELNTKSDYCQECGY-DGEiqiitdeegklVWECPHCG 682
Cdd:PRK08270 619 YITITPTFSICPKHGYlSGE-----------HEFCPKCG 646
|
|
| Gly_radical |
pfam01228 |
Glycine radical; |
592-700 |
5.06e-23 |
|
Glycine radical;
Pssm-ID: 426140 [Multi-domain] Cd Length: 106 Bit Score: 94.16 E-value: 5.06e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 592 VREEIDAFSKLKFESQFQALSSGGAISY-VEVPDMKDNIAAVLQVIRFiYDNIMYAELNTKSDYCQECGYDGEIQIITDE 670
Cdd:pfam01228 1 VAPGISPSHGADFEGPTAVLNSVGKIDYeVELDGISLNQKFLPAVLGY-YDEEGYANLNTLIDTYFEGGHHLQFNVVDRE 79
|
90 100 110
....*....|....*....|....*....|
gi 941714306 671 EgklvweCPHCGNRNQDTLNVARRTCGYIG 700
Cdd:pfam01228 80 T------LPDAQKHPEKYPDLTVRVSGYSA 103
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
1-90 |
1.19e-20 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 86.55 E-value: 1.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 1 MKIIKRNGSEETFDIQKIVVAVTKADKDNGErtltdsQIEDIAEYVEFK-CNKLNRAVSVEEIQDMVENQIMATGAFELA 79
Cdd:pfam03477 1 MKVIKRDGRREPFDKEKIRRAIEKACEKSPD------QADELASEVEEElEKSLEDGISTEEIQDLVEKTLAEHPDYAVA 74
|
90
....*....|.
gi 941714306 80 RKYVRYRYKRS 90
Cdd:pfam03477 75 RAYILYRNLRK 85
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
147-637 |
2.69e-17 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 84.51 E-value: 2.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 147 PHDIVEADREGIIHFHDSDYYaqhMHNCDLVNLEDMLQNGTVIsgtMIEKPHSFSTACNIATQIIAQVASNQ-YGGQSIS 225
Cdd:cd00576 1 AERIYEAVKSGVITVGRPDLP---FTGCVLVDYGDSLDPGIKG---VNETAKSINEAIQKTYQIIALAASNQnGGGVSFA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 226 LAHLAPFVDVSREKIRKEvISEQELVGMeypEDVLNEIVerrlkKEITKGvqtieyqvitlmttNGQAPFLTVFMYLNEA 305
Cdd:cd00576 75 RASSILSPYGSRDYAKGS-GTETDAVEA---ADAFNLAL-----KEVGQG--------------NGRTGAATGFIGGVHK 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 306 KNERekkdlaMIIEETLRQRYqgvKNEAGVWVTPaFPKLIYVLEEDNIEEGSEYYYLTELAAKCTAKRLVPDYISekkmk 385
Cdd:cd00576 132 GKGD------KISQEFLNLAL---ANGGEGIPLN-FPNLSVRVSSDKPGILVKAVELKQLIAEEARKTGSPGIFN----- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 386 elkegncfpvmgcrsclspwkDENGNYkfygrfnqgvVTINLVDVALSS-GGDMDKFWKIFDDRLELCYRALMCRHNRLK 464
Cdd:cd00576 197 ---------------------DELCNL----------VSLNLARIMEKAiNGSMDVVLEELEELAFLAVRALDCVIDSHD 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 465 gtlsdaapilwqfgalarlkkgEPIDKLLYGG--YSTISLGYAGLYECVKYMTGKSHTDPDATPFALDVMKHMNDACNQW 542
Cdd:cd00576 246 ----------------------ERIPTIELGGdeRRTVGLGIAGVADLLIKLGLEKVGDPEADDLAAELVDQLKKHLVKA 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 543 KEETNVAFSIYGSPIESttykfakclqkrfgivpgITDKSYITNSYHV-------FVREEIDAFSKLKFESQFQALSSGG 615
Cdd:cd00576 304 TNERGFNFLLGLSPSES------------------NSSGAPATNGVSPsrg*iaiVLNGDIGPEESLASVAILQFYADNG 365
|
490 500
....*....|....*....|..
gi 941714306 616 AISYVEVPDMKDNIAAVLQVIR 637
Cdd:cd00576 366 ISDTITIPDSATNLDQLLAVID 387
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-117 |
3.67e-16 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 82.88 E-value: 3.67e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 1 MKIIKRNGSEETFDIQKIVVAVTKADKDNGeRTLTDSQIEDIAEYVEFKCNKLNRA---VSVEEIQDMVENQIMATGAFE 77
Cdd:PRK12364 1 MEIIKRNGTTEPYDREKIEVAIRKAFASVG-KPISDEIIYSLVAEVERFIKEKYPNghnVSVEEIQDLVEKTLMEHGHYA 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 941714306 78 LARKYVRYRYKRSLVRKA------NTTDNRILSLIEYNNEDVKQEN 117
Cdd:PRK12364 80 EVKSYILYRAQRTEKRKAreqiikFFDDDTVLGVLKEIQKDFPSDE 125
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-99 |
2.84e-12 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 70.38 E-value: 2.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 1 MKIIKRNGSEETFDIQKIVVAVTKAD-KDNGERTLTDSQIEDI-AEYVEFKCNKLNR------AVSVEEIQDMVENQIMA 72
Cdd:PRK07207 34 YKVIRRNGSVVPFEPSKIAVAMTKAFlAVEGGQAAASARVRETvEQLTEQVVRALVRrrpsggTFHIEDIQDQVELALMR 113
|
90 100
....*....|....*....|....*..
gi 941714306 73 TGAFELARKYVRYRYKRSLVRKANTTD 99
Cdd:PRK07207 114 SGEHKVARAYVLYREKRAQERAAEAEA 140
|
|
| PRK08271 |
PRK08271 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
416-718 |
3.05e-09 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 181342 [Multi-domain] Cd Length: 623 Bit Score: 60.02 E-value: 3.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 416 GRFNqgVVTINLVDVALSsGGDMDKFWKIFDDRLELC------YRALMCRHNRlKGTLS--DAAPILwqfgalarlkkge 487
Cdd:PRK08271 349 GSIN--VITINLPRIAQE-ARDRDDFLEILRERVDKIhkyqlaYREIMEERIA-AGMLPlyDAGFIS------------- 411
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 488 pIDKLlyggYSTIslGYAGLYECVKYMTGKSHTDPDATPFALDVMKHMNDACNQWKEETNVAFSIYGSPIESTTYKFAKC 567
Cdd:PRK08271 412 -LDKQ----FLTI--GINGMVEAAEFMGLTVGYNEEYKDFVQEVLKVIYEANEKASKEYGFTFNTEFVPAENLGVKLAKW 484
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 568 LQKrfgIVPGITDKSYitNSY-HVFVREEIDAFSKLKFESQF--QALSSGGAI-----SYVEVPDMKD--NIAAVLQVir 637
Cdd:PRK08271 485 DRE---DGYGVPRQCY--NSYsYVVEDANTDALDKFKLHGKEldKYLSGGSALhlnldERLSEEGYRKllNIAAKTGC-- 557
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 638 fiydniMYAELNTKSDYCQECGYdgeiqiITDEEGKlvwECPHCGNRNQDTLNvarRTCGYIG-TQFWNQGRTQEIKERV 716
Cdd:PRK08271 558 ------NYFAFNVKITICNDCHH------IDKRTGK---RCPICGSENIDYYT---RVIGYLKrVSAFSKVRQKEYPRRH 619
|
..
gi 941714306 717 LH 718
Cdd:PRK08271 620 YH 621
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-117 |
8.52e-09 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 59.19 E-value: 8.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 1 MKIIKRNGSEETFDIQKIVVAVTKA----DKDNGER-TLTDSQIED----IAEYVEFKCNKlNRAVSVEEIQDMVENQIM 71
Cdd:PRK12365 118 LSVIRRDGTVVHFNPMKISAALEKAfratDKIEGMTpSSVLEEINAltqnIVEEILECCSQ-EDRIDIEKIQDIVEQQLM 196
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 941714306 72 ATGAFELARKYVRYRYKRSLVRKANTTDNRILSLIEYNNEDVKQEN 117
Cdd:PRK12365 197 VVGHYDVAKNYILYREARARVRDNKEEDGSTEKTIAEEAYEVLSKD 242
|
|
| PRK08579 |
PRK08579 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
421-716 |
3.18e-08 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236303 [Multi-domain] Cd Length: 625 Bit Score: 57.07 E-value: 3.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 421 GVVTINLVDVALSSGGDMDKFWKIFDDRLELCYRALMCRHNRLKGTLSdAAPILWQFGAlarlkkgEPIDKLLYGGYSTI 500
Cdd:PRK08579 337 NVTTVNLPRIALEARGDDDKFWELYEERLELVRITLDWFRERYVKLLK-TYPEMYSMIK-------EYLEEFPSSHFNTI 408
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 501 slGYAGLYECVKYMTGK-------SHTDPDAtpfALDVMKHM----NDACNQWKEETNVAFSIYGSPIESTTYKFAKCLQ 569
Cdd:PRK08579 409 --GIIGLPEAAAIYLGEpklwtegSRRDWLE---AAELMKKMvefaVEKAREWMKETGTPWNVEEVPGESAAAKLAIKDL 483
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 570 KRF----GIVPGITDKSYITN---SYHvfvreEIDAFSKLKFESQFQALSSGGAISYV---EVPDMKdniaAVLQVIRFI 639
Cdd:PRK08579 484 KLFpelrEYLSDPENPIYSTSiapYYG-----PLELWDRIEIEEKVQQEFTGGVMMHIflgEEPDPE----ALAKLTKRI 554
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 941714306 640 YD-NIMYAELNTKSDYCQECGYDGEiqiitdeegKLVWECPHCGNRNQDtlnVARRTCGYI-GTQFWNQGRTQEIKERV 716
Cdd:PRK08579 555 MNtKLVYWSYTPAITVCNKCGRSTT---------GLYTRCPRCGSEDVE---VWSRIIGYYrPLKNWNPYRKKEFWLRK 621
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
2-156 |
6.13e-08 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 56.31 E-value: 6.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 2 KIIKRNGSEETFDIQKIVVAVTKADKDNGERTltDSQIEDIAEYVEFKCNKL--NRAVSVEEIQDMVENQIMATGAFELA 79
Cdd:PRK08332 5 KVMKRDGRIVPFDESRIRWAVQRAMWEVGVRD--EKKLDEVVKRIVQRINELydGKIPHIENIQDIVELELMRAGLFEVA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 80 RKYVRYRYKRSLVRKANttdNRILSLIEYNNEDvkqensnKNPAVNSVqrdymagevsRDLTTRMLLPHD---IVEADRE 156
Cdd:PRK08332 83 KAYILYRKKKAEIREEK---KRILNKKELDEID-------KRFSINAL----------RVLASRYLKKDEngnIIESPRE 142
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
1-95 |
1.49e-07 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 54.86 E-value: 1.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 1 MKIIKRNGSEETFDIQKIVVAVTKADKDNGERTLTDSqiEDIAEYVEFKCNKLNRAvSVEEIQDMVENQIMATGAF---- 76
Cdd:PRK06406 5 KEVIKRDGTVVPFDKKKIAMAIYKAMLSVKNGSMEDA--EELTDKVVERLKKYERP-TVEQIQDIVEKVLMTKKINgkdf 81
|
90 100
....*....|....*....|
gi 941714306 77 -ELARKYVRYRYKRSLVRKA 95
Cdd:PRK06406 82 tDVAKSYILYREKRRKIREE 101
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
3-94 |
1.09e-06 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 52.26 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941714306 3 IIKRNGSEETFDIQKIVVAVTKADKDNgeRTLTDSQ---------IEDIA-EYVEFKCNKLN--RAVSVEEIQDMVENQI 70
Cdd:PRK12365 11 IVKRNGMFVPFNQNRIFQALEAAFRDT--RSLEDHSplpedlessIRSIThQVVKEVVQKITegQVVTVERIQDMVESQL 88
|
90 100
....*....|....*....|....
gi 941714306 71 MATGAFELARKYVRYRYKRSLVRK 94
Cdd:PRK12365 89 YVNGLQDVARDYIVYRDDRKAHRK 112
|
|
| |
