|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
27-442 |
7.29e-108 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 325.74 E-value: 7.29e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 27 IFSITFGFFGVNMAFALQSAMMGRIFQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDRTWTRFGRRMPYLLIAGPIGA 106
Cdd:cd17313 1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 107 IVLVLLPNAGSFDFGYASLM---ALSFGAVMTLLMDLTANACMQPYKMIIGDMVNEKQRDMAWSWQQIFSNLGGIIATLL 183
Cdd:cd17313 81 LGLILIPNAADIGLALGDGPrtwALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 184 PFLLTMLGMSNVApkgeVPMTVKLAYYIAAAVLLIASIWTVISVREYEPKTYNYYHGINENNRNNKLNLLQLLKKAPKQF 263
Cdd:cd17313 161 GAILWDHNWFGFA----LGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSLLKLLKIMPRSL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 264 WQISVVQFFNWFALMYLWTYSTGAIAKNVWNVTDPSSAGYQAAGNWYGVLYCIQFLSSVIFGFVIAR-SKPSQRKFWYSF 342
Cdd:cd17313 237 LRLLLVIFFWWIAFFPFELFFTDYMGEEVYHGTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKlGKKIGRKKVYLI 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 343 GLVFGGIGLISIFFIHNQWLLIFSFVLIGINNLTMNTQPFTLLTEAID--GENSGAYLGLFNTSICLPQIVASIASFGLY 420
Cdd:cd17313 317 GLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSesGRGQGTDTGLLNLAISLAQILVSLLAGPII 396
|
410 420
....*....|....*....|....
gi 920619860 421 --PLLGSSMPAMLLLAGIMMLLGA 442
Cdd:cd17313 397 dvKGYGTVFPVAAVASFLSLVGAL 420
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
22-447 |
2.05e-49 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 174.32 E-value: 2.05e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 22 LKKAVIFSITFGFFGVNMAFALQSAMMGRIFQT-LGANPNNLGWFFILPPLVGMIVQPLIGYYSDRTWTRFGRRMPYLLI 100
Cdd:COG2211 7 LSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDvLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 101 AGPIGAIVLVLLPNAGSFDFGYASLMAlsfgAVMTLLMDLTANACMQPYKMIIGDMV-NEKQRDMAWSWQQIFSNLGGII 179
Cdd:COG2211 87 GAIPLALSFVLLFTAPDLSPTGKLIYA----LVTYLLLGLAYTLVNIPYSALGAELTpDYEERTRLSSWRFAFAGLGGLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 180 ATLLPFLLTMLGMSNvapkgeVPMTVKLAYYIAAAVLLIASIWTVISVREYepktynyyhgINENNRNNKLNLLQLLKKA 259
Cdd:COG2211 163 ASVLPPPLVAAFGGD------AALGYRLTALIFAVLGLLAFLLTFFGTKER----------PVPEEEKVSLKESLKALLK 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 260 PKQFWQISVVQFFNWFALMYLWTYSTGAIAKNVwnvtdpssagyQAAGNWYGVLYCIQFLSSVIFGFVIAR-SKPSQRKF 338
Cdd:COG2211 227 NRPFLLLLLAYLLFFLALALVAALLLYYFKYVL-----------GLSAALVGLLLALYFLAALLGAPLWPRlAKRFGKKK 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 339 WYSFGLVFGGIGLISIFFI--HNQWLLIFSFVLIGINNLTMNTQPFTLLTEAID-------GENSGAYLGLFNTSICLPQ 409
Cdd:COG2211 296 AFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQ 375
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 920619860 410 IVASIASFGLYPLLG-------------SSMPAMLLLAGIMMLLGAVSVKF 447
Cdd:COG2211 376 ALAGALAGLLLALFGyvagaaqspsaltGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-445 |
1.01e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 81.32 E-value: 1.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 30 ITFGFFGVNMAFALQSAMMGRIFQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDRtwtrFGRRmPYLLIAGPIGAIVL 109
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADR----FGRR-PVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 110 VLLPNAGSFDFGYASLMALSFGAVMTLLMDLTanacmqpykmIIGDMVNEKQRDMAWSWQQIFSNLGGIIATLLPFLLTM 189
Cdd:cd06174 76 LLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLA----------LIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 190 LGMSNVapkgevpmtvKLAYYIAAAVLLIASIWTVISVREYEPKTYNyyhgINENNRNNKLNLLQLLKKAPKQFWQISVV 269
Cdd:cd06174 146 SLGFGW----------RAVFLIAAALALLAAILLLLVVPDPPESARA----KNEEASSKSVLKLLKRVLKNPGLWLLLLA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 270 QFFNWFALMYLWTYSTGAIAKNVWNvtdpssaGYQAAGNWYGVLYCIQFLSSVIFGFVIARskPSQRKFWYSFGLVFGGI 349
Cdd:cd06174 212 IFLVNLAYYSFSTLLPLFLLDLGGL-------SVAVAGLLLSLFGLAGALGSLLLGLLSDR--LIGRKPLLLIGLLLMAL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 350 GLISIFFIHNQWLLIFSFVLIGINNLTMNTQPFTLLTEAIDGENSGAYLGLFNTSICLPQIVASIASFGLYPLLGSSMPA 429
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGA 362
|
410
....*....|....*.
gi 920619860 430 MLLLAGIMMLLGAVSV 445
Cdd:cd06174 363 FLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-443 |
1.32e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.08 E-value: 1.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 30 ITFGFFGVNMAFALQSAMMGRIFQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDrtwtRFGRRMPylLIAGPIG-AIV 108
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD----RFGRKRL--LLLGLLLlAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 109 LVLLPNAGSFD--FGYASLMALSFGAVMTLLMdltanacmqpykMIIGDMVNEKQRDMAWSWQQIFSNLGGIIATLL-PF 185
Cdd:cd17325 75 TLLFAFATSYWqlLLARFLQGLASAAVWPAAM------------ALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLgGL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 186 LLTMLGMsnvapkgevpmtvKLAYYIAAAVLLIASIWTVISVREYEPKTYnyyhgiNENNRNNKLNLLQLLKKAPKQFWQ 265
Cdd:cd17325 143 LADALGY-------------RAPFLVCAALALLALVLALLLLPEPRPPPN------KRAVSAARLRSGLRLLLRDRRLLA 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 266 ISVVQFFNWFALMYLWTYsTGAIAKNVWNVTDpssagyQAAGNWYGVLYCIQFLSSVIFGFVIARSKpsqRKFWYSFGLV 345
Cdd:cd17325 204 LFLAIFVLAFAFGALEPF-LPLYAAELGGLSP------AQIGLLFGAQGLASALSQPPAGKLSDRIG---RKPLILIGLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 346 FGGIGLISIFFIHNQWLLIFSFVLIGINNLTMNTQPFTLLTEAIDGENSGAYLGLFNTSICLPQIVASIASFGLYPLLGs 425
Cdd:cd17325 274 LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG- 352
|
410
....*....|....*...
gi 920619860 426 sMPAMLLLAGIMMLLGAV 443
Cdd:cd17325 353 -FATPFLAAAALLLLAAV 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-405 |
5.60e-15 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 75.78 E-value: 5.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 18 TLPYLKKAVIFSITFGFFGVNMAFALQSAMMGRIFQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDrtwtRFGRRmPY 97
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD----RFGRR-RV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 98 LLIAGPIGAIVLVLLPNAGSFDFGYAS--LMALSFGAVMTLLMdltanacmqpykMIIGDMVNEKQRDMAWSWQQIFSNL 175
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPSLWLLLAArfLQGLGAGALFPAAL------------ALIADLVPPERRGRALGLLGAGLGL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 176 GGIIATLL-PFLLTMLGMSnvapkgevpmtvkLAYYIAAAVLLIASIWTVISVREYEPKTynyyhginennrNNKLNLLQ 254
Cdd:COG2814 146 GPALGPLLgGLLADLFGWR-------------WVFLVNAVLALLALLLLLRLLPESRPAA------------RARLRGSL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 255 LLKKAPKQFWQISVVQFFNWFALMYLWTYSTgAIAKNVWNVTDpssagyQAAGNWYGVLYCIQFLSSVIFGFVIARSKps 334
Cdd:COG2814 201 RELLRRPRLLLLLLLAFLLGFGFFALFTYLP-LYLQEVLGLSA------SAAGLLLALFGLGGVLGALLAGRLADRFG-- 271
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 920619860 335 qRKFWYSFGLVFGGIGLISIFFIHNQWLLIFSFVLIGINNLTMNTQPFTLLTEAIDGENSGAYLGLFNTSI 405
Cdd:COG2814 272 -RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
71-390 |
1.58e-13 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 71.87 E-value: 1.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 71 LVGMIVQPLIGYYSDRTWTRFGRRMPYLLIAGPIGAIVLVLL----PNAGSFDFGYASLMALSFGAVMTlLMDLtanacm 146
Cdd:cd17332 46 IIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPLALLFVLLfttpDGSGTGKLIYALITYILLDLLYT-LVNI------ 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 147 qPYKMIIGDMVNE-KQRDMAWSWQQIFSNLGGIIAT-LLPFLLTMLGMSNVAPkgevpmTVKLAYYIAAAVLLIASIWTV 224
Cdd:cd17332 119 -PYTALIPELTDDpEERTSLTSWRMFFATIGGLLVTvLPPPLVAYFGGGNASR------GYFLTALIIGIIGIILLLICF 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 225 ISVREYEPKTynyyhgiNENNRNNKLNLLQLLKKAPKQFWQISVVQFFNWFALMYLWTYSTGAIAKNVWNvtdpssagyQ 304
Cdd:cd17332 192 FGTRERVVPP-------EEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGG---------R 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 305 AAGNWYGVLYCIqFLSSVIFGFVIARSKPSQRKFWYsFGLVFGGIGLISIFFI--HNQWLLIFSFVLIGINNLTMNTQPF 382
Cdd:cd17332 256 AELVLLLLLILS-GALLALLPWPPLKKRFGKKKAFF-IGLLLAILGLLLLFFLppGNLVLILVLAVLAGIGYGGANLLPW 333
|
....*...
gi 920619860 383 TLLTEAID 390
Cdd:cd17332 334 AMLADVID 341
|
|
| GPH_sucrose |
TIGR01301 |
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ... |
36-441 |
1.76e-12 |
|
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.
Pssm-ID: 273545 [Multi-domain] Cd Length: 477 Bit Score: 69.06 E-value: 1.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 36 GVNMAFALQSAMMGRIFQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDRTWTRFGRRMPYlLIAGPIGAIVLVLLpna 115
Cdd:TIGR01301 15 GVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPF-IAAGAALVAFAVIL--- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 116 gsfdFGYASLMALSFGAVMT---------------LLMDLTANACMQPYKMIIGDMVNEKQRDM--AWSWQQIFSNLGGI 178
Cdd:TIGR01301 91 ----IGFAADIGHLFGDNLDkktkpraiivfvvgfWILDVANNMLQGPCRAFLADLTGGDARRTriANAYFSFFMAIGNV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 179 IA----------TLLPFLLTMLGMSNVApkgevpmTVKLAYYIAAAVLLIASIWTVISVReyEPKTYNYYHGINENNRNN 248
Cdd:TIGR01301 167 LGyaagaysglyKIFPFTKTEACGVSCA-------NLKSCFLIDIILLAILTYIALSAVK--ENPLIGSDDFINSEAAPP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 249 KLNLLQLLKKA--------PKQFWQISVVQFFNWFALMYLWTYSTGAIAKNVWNVTDPSSAGYQaAGNWYGVLYCIqfLS 320
Cdd:TIGR01301 238 SKHGEEAFFGElfgafkylPRPVWILLLVTCLNWIAWFPFILFDTDWMGREVYGGSVNQGAKYD-DGVRAGAFGLM--LN 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 321 SVIFGFV------IARSKPSQRKFW----YSFGLVFGGIGLISIFFIHNQW------------------LLIFSfvLIGI 372
Cdd:TIGR01301 315 SVVLGITsigmekLCRGWGAGKRLWgivnIILAICLAATVLVTYVAKNSRYydgdgeslppptgikasaLIVFA--ILGI 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 373 NNLTMNTQPFTLLteAIDGENSGA----YLGLFNTSICLPQIVASIASFGLYPLL-GSSMPAML------LLAGIMMLLG 441
Cdd:TIGR01301 393 PLAITYSIPFALA--SIRSSNLGAgqglSMGVLNLAIVIPQIIVSLGSGPWDQLFgGGNLPAFVvgavaaFVSGLLALIL 470
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
30-413 |
6.70e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 66.67 E-value: 6.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 30 ITFGFFGVNMAFALQSAMMGR-IFQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDRtwtrFGRRMPYLliagpIGAIV 108
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR----FGRRRVLL-----IGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 109 LVLLPNAGSFDFGYASLMALSFgavmtlLMDLTANACMQPYKMIIGDMVNEKQRDMAWSWQQIFSNLGGIIATLL-PFLL 187
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRV------LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLgGLLA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 188 TMLGMsnvapkgevpmtvKLAYYIAAAVLLIASIWTVISVREYEPKTYNYYHGINENNRNNKLnllqllkkapkqfwQIS 267
Cdd:pfam07690 146 SLFGW-------------RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWK--------------ALL 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 268 VVQFFNWFALMYLWTYSTGAIAKNVWNVTDPSSAGYQAAGNWYGVLYCIQFLSSVIFGFVIARSKPSQRKFWYSFGLVFG 347
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 920619860 348 GIGLISIFFIHNQWLLIFSFVLIGINNLTMNTQPFTLLTEAIDGENSGAYLGLFNTSICLPQIVAS 413
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
26-451 |
2.64e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.89 E-value: 2.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 26 VIFSITFGFFGVNMAFALQSAMMGRIFQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDRtwtrFGRRMPYLLIAGpIG 105
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADR----FGRRRVLAIGLL-LW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 106 AIVLVLLPNAGSFDFGYASLMALSFGAVMTLLMDLTanacmqpykmIIGDMVNEKQRDMAWSWQQIFSNLGGIIATLL-P 184
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALK----------LIAEWFPPKERGRALGIFNAGGPLGGALAPPLlG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 185 FLLTMLGMsnvapkgevpmtvKLAYYIAAAVLLIASIWtvisvreyepktynyyhginennrnnklnllqllkkapkQFW 264
Cdd:COG2271 156 WLLAAFGW-------------RAAFLILGLPGLLLALL---------------------------------------RFW 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 265 QISVVQFFNWFALMYLWTYSTgAIAKNVWNVTDpssagyQAAGNWYGVLYCIQFLSSVIFGFVIARSKpSQRKFWYSFGL 344
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLP-TYLVEVRGLSL------AQAGLLLSLPFLAGIVGSLLGGWLSDRLG-RRRKLVLAIGL 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 345 VFGGIGLISIFFIHNQWLLIFSFVLIGINNLTMNTQPFTLLTEAIDGENSGAYLGLFNTSICLPQIVASIASFGLYPLLG 424
Cdd:COG2271 256 LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
410 420
....*....|....*....|....*..
gi 920619860 425 ssMPAMLLLAGIMMLLGAVSVKFINAK 451
Cdd:COG2271 336 --YQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
53-390 |
9.33e-10 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 60.40 E-value: 9.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 53 QTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDRTWTRFGRRMPYLLIAGPIGAIVLVLLPNAgsFDFGYASLMALSFga 132
Cdd:pfam13347 26 DVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAVSFILLFTP--PELGRAPLFIWLL-- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 133 VMTLLMDLTANACMQPY-KMIIGDMVNEKQRDMAWSWQQIFSNLGGIIATLLPF-LLTMLGMSNVAPKGEVPMTVklayy 210
Cdd:pfam13347 102 ATYILLRIAYTFFEIPYwSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFpLVLILGGTGLERKGYRIFAL----- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 211 IAAAVLLIASIWTVISVREYEPKTYNYYHGINENNRNNKLNLLQLLKkapKQFWQISVVQFFNWFALM-------YLWTY 283
Cdd:pfam13347 177 IGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDMLKEVFRN---RAFLILLASFLLAALAMGvlnglllYYFRY 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 284 STGAiaknvwnvtdpssagYQAAGNWYGVLYCIQFLSSVIFGFviARSKPSQRKFWYsFGLVFGGIGLISIFFIH--NQW 361
Cdd:pfam13347 254 VLGN---------------GFAASAFPLVFTIGALLGIPLWPP--LAKRIGKKNTYI-LGALITIAGFALALLLGpnNTL 315
|
330 340
....*....|....*....|....*....
gi 920619860 362 LLIFSFVLIGINNLTMNTQPFTLLTEAID 390
Cdd:pfam13347 316 LFLVLYIIIGFGYGSSFFLPWSMLADVVD 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
26-445 |
1.25e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.81 E-value: 1.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 26 VIFSITFGFFGVNMAFALQSAMMGRIFQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDrtwtRFGRRMPYLLIAgpig 105
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD----RFGPRRVLLIGL---- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 106 aiVLVLLPNAGSfdfGYA-SLMALSFGAVMTLLMDLTANACMQPYkmiIGDMVNEKQRDMAWSWQQIFSNLGGIIATLL- 183
Cdd:COG2223 78 --LLLGIGLLLL---ALAvSYWLLLLLGLLLGIGGGGSFAVGIAL---VSKWFPPDRRGLALGLAAGGGNLGAAVAAFLa 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 184 PFLLTMLGMSNvapkgevpmtvklAYYIAAAVLLIASIWTVISVREYEPktynyyhgiNENNRNNKLNLLQLLKKAPKQF 263
Cdd:COG2223 150 PLLIAAFGWRN-------------AFLILGILLLVVAVLAWLFLRDPPA---------GAAAAAKASLRDQLEALRDPRF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 264 WQISVVQFFNWFALMYLWTYSTgAIAKNVWNVTDPssagyqAAGNWYGVLYCIQFLSSVIFGFVIARSKpsqRKFWYSFG 343
Cdd:COG2223 208 WLLSLLYFGTFGSFIGFSSWLP-PYLVDQFGLSAA------TAGLLAALFALLGALGRPLGGWLSDRIG---GRRVLLIV 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 344 LVFGGIGLI-SIFFIHNQWLLIFSFVLIGINNLTMNTQPFTLLTEAIDGENSGAYLGLFNTSICLPQIVASIASFGLYPL 422
Cdd:COG2223 278 FALMALGLLlLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357
|
410 420
....*....|....*....|...
gi 920619860 423 LGSSMPAMLLLAGIMMLLGAVSV 445
Cdd:COG2223 358 TGSYTAAFLVFAVLALVALVLTL 380
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
24-443 |
1.84e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.00 E-value: 1.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 24 KAVIFSITFGFFGVNMAFALQSAMMgrifQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDRtwtrFGRRmpYLLIAGP 103
Cdd:cd06173 2 RLLWLAQLLSALGDWIFTVALPWLV----LQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADR----FDRR--RLLILAD 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 104 I--GAIVLVLLPNAGSFDFGYASLMALSF-GAVMTLLMDLTANAcmqpykmIIGDMVNEKQRDMAWSWQQIFSNLGGIIA 180
Cdd:cd06173 72 LlrALLAAVLALLALLGSLSLWLLLVLAFlLGIASAFFGPARQA-------LLPELVPKEQLVRANALNSLATQLARIIG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 181 TLL-PFLLTMLGMSNVapkgevpmtvklayYIAAAVLLIASIWTVISVREYEPKTynyyHGINENNRNNKLNLLQLLKKA 259
Cdd:cd06173 145 PALgGLLVALLGPGGA--------------FAINALSFLLSALLLLFIRRPPPAA----PGESSSLLLRDLREGLRYLRR 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 260 PKQFWQISVVQFFNWFALMYLWTYSTgAIAKNVWNVTDpssagyqaagNWYGVLYCIQFLSSVIFGFVIAR-SKPSQRKF 338
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLP-LLAKEVLGGGA----------AGYGLLLAAFGVGALLGALLLGRlSKRRRRGR 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 339 WYSFGLVFGGIGLISIFFIHNQWLLIFSFVLIGINNLTMNTQPFTLLTEAIDGENSGAYLGLFNTSICLPQIVASIASFG 418
Cdd:cd06173 276 LLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL 355
|
410 420
....*....|....*....|....*
gi 920619860 419 LYPLLGssMPAMLLLAGIMMLLGAV 443
Cdd:cd06173 356 LADALG--LSAVFLLAGALLLLAAL 378
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
63-443 |
2.07e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.61 E-value: 2.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 63 GWFFILPPLVGMIVQPLIGYYSDRtwtrFGRRmPYLLIAGPIGAIVLVLLPNAGSFDFGYASLMALSFGAVmtlLMDLTA 142
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADR----FGRK-PVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGG---LFEPAS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 143 NAcmqpykmIIGDMVNEKQRDMAWSWQQIFSNLGGIIATLLPFLLTMLGMSnvapkgevpmtvkLAYYIAAAVLLIASIW 222
Cdd:cd17329 110 EA-------MIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFR-------------LLFLAAAVLFLLAALV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 223 TVISVREYEPKTynyyhginENNRNNKLNLLQLLKKAPKQFWQISVVQFFnwFALMYLWTYSTGAIAknvwnVTDPSSAG 302
Cdd:cd17329 170 LLFLLPETRPKR--------RAAEKTEILRGYKIVLRDRAFLLFLLASFL--ISLIYFQLESTLPVY-----VVEILGLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 303 YQAagnwYGVLYCIQFLSSVIFGFVIAR-SKPSQRKFWYSFGLVFGGIGLISIFFIHNQWLLIFSFVLIGINNLTMNTQP 381
Cdd:cd17329 235 ESL----LGLLLALNALLIVLLQFPVARlVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAV 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 920619860 382 FTLLTEAIDGENSGAYLGLFNTSICLPQIVASIASFGLYPLLGSSMPAMLLlaGIMMLLGAV 443
Cdd:cd17329 311 QTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLIL--AALGLIAAA 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
23-451 |
6.02e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 51.39 E-value: 6.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 23 KKAVIFSITFGFFGVNMAFALQSAMMGRIFQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDRtwtrFGRRmPYLLIAG 102
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDR----FGYK-RGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 103 PIGAIVLVLLPNAGSFDFGYASLMALSFGAVMTllmdltaNACMQPYKMIIGDmvneKQRDMAWSWQQIFSNLGGIIATL 182
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLL-------DVAANPYVAALGP----ETAASRLNLLHAFFSLGALLGPL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 183 LPFLLTMLGmsnvapkgeVPMTVKLAYYIAAAVLLIASIWTVISvreyepktyNYYHGINENNRNNKLNLLQLLKKAPKQ 262
Cdd:COG0738 150 LGGLLILLG---------LSLSWHLPYLILAVLLLLLALLFLRS---------KLPEIEEEEEEAAGSAASLKSLLKNPR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 263 FWQISVVQFFNWFALMYLWTYStGAIAKNVWNVTDpssagyQAAGNWYGVLYCIQFLSSVIFGFVIARSKPSQrkfWYSF 342
Cdd:COG0738 212 LLLGGLAIFLYVGAEGAIGDWL-PLYLKDVLGLSE------ATAALGLSLFWGGMTIGRFLGGFLLKRFGPVR---LLRL 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 343 GLVFGGIGLISIFFIHNQWLLIFSFVLIGINNLTMNTqpfTLLTEAID--GENSGAYLGLFNTS-----ICLPQIVASIA 415
Cdd:COG0738 282 SALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFP---TIFSLALDglGKRTAAAVSAVLIMgivggAIGPPLIGFLA 358
|
410 420 430
....*....|....*....|....*....|....*..
gi 920619860 416 -SFGLYpllgSSMPAMLLLAGIMMLLGAVSVKFINAK 451
Cdd:COG0738 359 dAFGLR----AAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
28-228 |
1.78e-06 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 49.94 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 28 FSITFGFFGVNMAFALQSA-MMGRIFQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDRTWTRFGRRMPYLLIAGPIGA 106
Cdd:TIGR00792 2 LSYGFGDFGNDFIFAIVSTyLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPFS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 107 IVLVLLPNAgsFDFGYASLMAlsFGAVMTLLMDLTANACMQPYKMIIGDMVNEKQ-RDMAWSWQQIFSNLGG-IIATLLP 184
Cdd:TIGR00792 82 IVLVLLFTT--PDFSGTGKLV--YAYITYILLGLFYSFVNIPYWSLVPAITLDPReRESLSTFRRFGATLGGlLVAVIVL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 920619860 185 FLLTMLGMSNvapkgevpmtVKLAYYIAAAVL-LIASIWTVISVR 228
Cdd:TIGR00792 158 PLVSYFGGGD----------DKFGWFMFALVLaLIGVVSLIICFF 192
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
39-444 |
3.53e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.11 E-value: 3.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 39 MAFALQSAMMGRIFQTLGANPNNL-GWFFILPPLVGMIVQPLIGYYSDRtwtrFGRRMpyLLIagpIGAIVLVLLPNAGS 117
Cdd:cd17473 13 MAGAAIAPALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADR----FGRKR--LLI---AGLLLYGIGGVAGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 118 FDFGYASLMALSF------GAVMTLLMDLtanacmqpykmiIGDMVNEKQRDMAWSWQQIFSNLGGIIATLLPFLLTMLG 191
Cdd:cd17473 84 FLDSLYALLASRAllgigvAGIMTLATAL------------IGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 192 MSNVapkgevpmtvkLAYYIAAAVLLIASIWTVisvreYEPKTynyyhginENNRNNKLNLLQLLKKAPKQFWQISVVQF 271
Cdd:cd17473 152 WRAP-----------FLVYLLALPVLILVLLFL-----PEPAR--------KSKSAASPGAATAAALPWKRVLPIYFLAF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 272 FNwFALMYLWTYSTGAIAKNVwNVTDPSSAGYQAAGNWYGVlyciqFLSSVIFGFVIARSKpsqRKFWYSFGLVFGGIGL 351
Cdd:cd17473 208 LA-MLLFYVIPIQLPFLLQER-GGGSAALIGLALAIASLAG-----AIGALLFGRLKRRLG---KRRLLAIGFALMALGF 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 352 ISIFFIHNQWLLIFSFVLIGINNLTMNTQPFTLLTEAIDGENSGAYLGLFNTSICLPQIVASIASFGLYPLLGSSMPAML 431
Cdd:cd17473 278 LLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFL 357
|
410
....*....|...
gi 920619860 432 LLAGIMMLLGAVS 444
Cdd:cd17473 358 ILGVLALVLAIVL 370
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
24-448 |
5.16e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 48.34 E-value: 5.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 24 KAVIFSITF-GFFGVNMAFALQSAMMgrifQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDRtwtrFGRR---MPYLL 99
Cdd:cd17474 1 LYAVFFATLlAVLGVSIVDPILPAIA----EALGASPAQVGLLITAFTLPAAVLMPVAGVLADR----FGRKkvlLPGLL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 100 IAGPIGAIVLVllpnAGSFDFGYASLMALSFGAVMTLLMDLTanacmqpykmIIGDMVNEKQRDMAWSWQQIFSNLGGII 179
Cdd:cd17474 73 LFGIGGLLCGL----SDSFALLLAGRALQGIGAAGLGPLALT----------LIGDLFEGGERAKAMGLYEAALGLGIAV 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 180 ATLLPFLLTMlgMSNVAPKgevpmtvkLAYYIAAAVLLIASIWTVISVREYEPKTYNYYHGInennrnnklnllQLLKKA 259
Cdd:cd17474 139 GPLLGGLLAA--ISWRYPF--------FLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRD------------LKKALR 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 260 PKQFWQISVVQFFNWFALMYLWTYSTgaiaknvwnvtDPSSAGYQAAGNWYGVLYCIQFLSSVIFGFVIAR--SKPSQRK 337
Cdd:cd17474 197 GRGLLTFLVSAFLYFFLYFAFLTYLP-----------FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRllKKRFGAR 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 338 FWYSFGLVFGGIGLISIFFIHNQWLLIFSFVLIGINNLTMNTQPFTLLTEAIDGENSGAYLGLFNTSICLPQIVASIASF 417
Cdd:cd17474 266 RILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFG 345
|
410 420 430
....*....|....*....|....*....|.
gi 920619860 418 GLYPLLGSSMPamLLLAGIMMLLGAVSVKFI 448
Cdd:cd17474 346 LLLEIFGLSAP--FLVGAAIALAAAVLLALL 374
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
71-451 |
5.41e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 48.61 E-value: 5.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 71 LVGMIVQPLIGYYSDRTwtrfGRRMPYLLIAGPIGAIVLVLLpnagsfdfGYASLMALSFGAVMTLLMDLTANACMQPYK 150
Cdd:COG2270 63 LLVALLAPVLGAIADRS----GRKKPFLAFFTLLGVLATAAL--------FFVAPGGLWLGLLLFVLANIGFEGSLVFYN 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 151 MIIGDMVNEKQRDMAWSWQQIFSNLGGIIatLLPFLLTMLGMSNVAPKGEVPMTVKLAYYIAAAVLLIASIWTVISVREy 230
Cdd:COG2270 131 AFLPDIATPEEIGRVSGLGWALGYLGGVL--LLLINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPE- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 231 EPKTYNYYHGINENNRNNKLNLLQLLKKAPKQFWQISVVQFFNWFALMYLWTYSTGAIAKNV-WNVTDPSSAG--YQAAG 307
Cdd:COG2270 208 RPRPGPAPPRGAVRAGFRELRRTLRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLgFSTTELIVFGllVQIVA 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 308 nwygvlyciqFLSSVIFGFVIAR--SKPSqrkfwYSFGLVFGGIGLISIFFIHNQWLLIFSFVLIGINNLTMNTQPFTLL 385
Cdd:COG2270 288 ----------ALGALLFGRLDDRigPKRV-----ILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLL 352
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 920619860 386 TEAIDGENSGAYLGLFNTSICLPQIVASiASFGLYPLLGSSMPAMLLLAGIMMLLGAVSVKFINAK 451
Cdd:COG2270 353 ARLIPPGREAEFFGLYALSGKAASFLGP-LLFGLVTQLTGSQRLGILSLIVFFVIGLVLLLRVKVP 417
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
56-196 |
1.21e-05 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 47.41 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 56 GANPNNLGWFFILPPLVGMIVQPLIGYYSDRTWTRFGRRMPYLL-IAGPIGAIVLVLLPNAgsfDFGYASlmALSFGAVM 134
Cdd:PRK09669 41 GLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFRPYLLwFAIPFGVVCLLTFYTP---DFGATG--KIIYACVT 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 920619860 135 TLLMDLTANACMQPYKMIIGDMVNE-KQRDMAWSWQQIFSNLGGIIATL--LPfLLTMLGMSNVA 196
Cdd:PRK09669 116 YILLSLVYTAINVPYCAMPGAITNDpRERHSLQSWRFALSFIGGLIVSViaLP-LVDILGKGDEQ 179
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
28-186 |
8.20e-05 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 44.70 E-value: 8.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 28 FSITFGFFGVNMAFALQSA-MMGRIFQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDRTWTRFGRRMPYLLIAGPIGA 106
Cdd:PRK10429 9 LSYGFGAFGKDFAIGIVYMyLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTRSRWGKFKPWILIGTLANS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 107 IVLVLLPNAGSFD----FGYASLMALSFGAVMTlLMDLtanacmqPY-KMIIGDMVNEKQRDMAWSWQQIFSNLGGII-- 179
Cdd:PRK10429 89 VVLFLLFSAHLFEgtaqYVFVCVTYILWGMTYT-IMDI-------PFwSLVPTLTLDKREREQLVPYPRFFASLAGFVta 160
|
....*..
gi 920619860 180 ATLLPFL 186
Cdd:PRK10429 161 GFTLPFV 167
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
4-181 |
2.08e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.18 E-value: 2.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 4 TNRTHKENKLEQDITLPYLKKAVIFSITFGFFGVNMAFALQSAMMGRIFQTLGANPNNLGWFFILPPLVGMIVQPLIGYY 83
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 84 SDRTWTRFGRRMPYLLIAGPIGAIVLVLLPNAGSFDFGYASLMALSFGAVMTLLMDLTAnacmqpykmiigDMVNEKQRD 163
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS------------DLAPKEERG 326
|
170
....*....|....*...
gi 920619860 164 MAWSWQQIFSNLGGIIAT 181
Cdd:pfam07690 327 TASGLYNTAGSLGGALGP 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
266-447 |
2.17e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.18 E-value: 2.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 266 ISVVQFFNWFALMYLWTYSTGAIAKNVwnvtdpsSAGYQAAGNWYGVLYCIQFLSSVIFGFVIARSKpsqRKFWYSFGLV 345
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDL-------GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG---RRRVLLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 346 FGGIGLISIFFIHNQWLLIFSFVLIGINNLTMNTQPFTLLTEAIDGENSGAYLGLFNTSICLPQIVASIASFGLYPLLGs 425
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG- 149
|
170 180
....*....|....*....|..
gi 920619860 426 sMPAMLLLAGIMMLLGAVSVKF 447
Cdd:pfam07690 150 -WRAAFLILAILSLLAAVLLLL 170
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
23-188 |
9.44e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.95 E-value: 9.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 23 KKAVIFSITFGFFGVNMAFALQSAMMGRIFQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDrtwtRFGRRMPYLLIAG 102
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGD----RYGRKRVLLIGLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 103 --PIGAIVLVLLPNAGSFDFGYAsLMALSFGAVMTLLMdltanacmqpykMIIGDMVNEKQRDMAWSWQQIFSNLGGIIA 180
Cdd:COG0477 88 lfGLASLLCGLAPSPELLIAARA-LQGIGAGGLMPGAL------------ALIAELFPARERGRALGLWGAAIGLGLALG 154
|
....*...
gi 920619860 181 TLLPFLLT 188
Cdd:COG0477 155 PLLGGLLV 162
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
39-443 |
9.77e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 9.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 39 MAFALqsamMGRIFQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDRTwtrfGRRMPYLLIAGPIGAIVLVLLPNAGSF 118
Cdd:cd17370 17 MARSI----LPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRT----GKRKPLVILGYGLSALAKPLLALAGSW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 119 DfgyaslmalsfGAVMTLLMDLTANACMQPYK-MIIGDMVNEKQRDMAWSWQQIFSNLGGIIATLLPFLLtmLGMSNVap 197
Cdd:cd17370 89 Q-----------LVLLLRILERLGKGIRTPPRdALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALL--LYLLGG-- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 198 kgevpmTVKLAYYIAAAVLLIASIWTVISVREYEPKtynyyhginenNRNNKLNLLQLLKKAPKQFWQISVVQFFNWFAl 277
Cdd:cd17370 154 ------NYRTIFLLAAIPALLALLILLFVVKEYPRP-----------PKLRKKSKKTSLKKLPKAFWLYLLAVALFALG- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 278 mylwtYSTGAIAknVWNVTDPSSAGYQAAGnWYGVLYCIQFLSSVIFGFVIARSKpsqRKFWYSFGLVFGGIGLISIFFI 357
Cdd:cd17370 216 -----NFSFAFL--ILRAQELGLSAALIPL-LYALFNLVYALAAYPAGRLSDRIG---RKKLLILGYLSLALAYLGFALG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 358 HNQWLLIFSFVLIGINNLTMNTQPFTLLTEAIDGENSGAYLGLFNTSICLPQIVASIASFGLYPLLGSSMPamLLLAGIM 437
Cdd:cd17370 285 SSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAA--FLFSAVL 362
|
....*.
gi 920619860 438 MLLGAV 443
Cdd:cd17370 363 ALIALL 368
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
309-448 |
2.85e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.72 E-value: 2.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 309 WYGVLYCIQFLSSVIFGFVIAR-SKPSQRKFWYSFGLVFGGIGLISIFFIHNQWLLIFSFVLIGINNLTMNTQPFTLLTE 387
Cdd:cd06174 32 QLGLLFALFSLGYALLQPLAGLlADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIAD 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 920619860 388 AIDGENSGAYLGLFNTSICLPQIVASIASFGLYPLLGSSMPAMLLLAGIMMLLGAVSVKFI 448
Cdd:cd06174 112 LFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLV 172
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
63-133 |
4.40e-03 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 39.41 E-value: 4.40e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 920619860 63 GWFFILPPLVGMIvQPLIGYYSDRTWTRFGRRMPYLLIAGPIGAIVLVLLPNA------GSFDFGYAsLMALSFGAV 133
Cdd:cd06176 39 GLLIALHYLVAPL-RVWIGHRSDTHPLRGYRRTPYIWLGMLLLALGLALAPFAalllagAAFWLGLA-LAVLAFLLY 113
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
26-233 |
8.83e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.32 E-value: 8.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 26 VIFSITFGFFGVNMAFALQSAMMGRifQTLGANPNNLGWFFILPPLVGMIVQPLIGYYSDRtwtrFGRRMPYLLIAGPIG 105
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYLV--DQFGLSAATAGLLAALFALLGALGRPLGGWLSDR----IGGRRVLLIVFALMA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920619860 106 AIVLVLLPNAGSFDFGYASLMALSFGAVMtllmdltANACMqpYKMIiGDMVNEKQRDMAWSWQQIFSNLGGIiatLLPF 185
Cdd:COG2223 283 LGLLLLALALGSLWLFLVLFLLLGLALGG-------GNGAV--FALV-PDIFPTKNAGAVYGLVGAAGGLGGF---LGPL 349
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 920619860 186 LLTMLGmsnvapkgEVPMTVKLAYYIAAAVLLIASIWTVISVREYEPK 233
Cdd:COG2223 350 LFGALL--------DATGSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| |
