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Conserved domains on  [gi|919193724|ref|WP_052749225|]
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type IV pilin protein [Rheinheimera mesophila]

Protein Classification

type IV pilin protein( domain architecture ID 11471939)

type IV pilin protein similar to Pseudomonas aeruginosa type IV pilus (T4P) non-core minor pilin PilE, an ssential component of the T4P that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, twitching, adhesion, and retraction of T4P fibers

Gene Ontology:  GO:0043683|GO:0016020
PubMed:  7854130|20338182

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
8-126 2.57e-25

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


:

Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 92.44  E-value: 2.57e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919193724   8 GFSLIELMIAITVAGILFAIALPAYQDYIMVSRRADAVESLFTLSQQLERQFTQSNSYTGLSLA---TSSSGGFYTISAE 84
Cdd:COG4968   11 GFTLIELMIVVAIIGILAAIAIPSYQDYVERARRAEAKAALLELAQAQERYYADNGSYPSALADlglPASTSGYYTISIA 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 919193724  85 itdtAFTLTATATGAQSADslcSTFTLNQRGEKgGSNPQECW 126
Cdd:COG4968   91 ----AAATTYTLTATPQAD---GTLTLDQTGVK-TATGADCW 124
 
Name Accession Description Interval E-value
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
8-126 2.57e-25

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 92.44  E-value: 2.57e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919193724   8 GFSLIELMIAITVAGILFAIALPAYQDYIMVSRRADAVESLFTLSQQLERQFTQSNSYTGLSLA---TSSSGGFYTISAE 84
Cdd:COG4968   11 GFTLIELMIVVAIIGILAAIAIPSYQDYVERARRAEAKAALLELAQAQERYYADNGSYPSALADlglPASTSGYYTISIA 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 919193724  85 itdtAFTLTATATGAQSADslcSTFTLNQRGEKgGSNPQECW 126
Cdd:COG4968   91 ----AAATTYTLTATPQAD---GTLTLDQTGVK-TATGADCW 124
ComP_DUS pfam16732
Type IV minor pilin ComP, DNA uptake sequence receptor; ComP-DUS is the DNA-uptake sequence ...
 35-83 1.15e-08

Type IV minor pilin ComP, DNA uptake sequence receptor; ComP-DUS is the DNA-uptake sequence receptor of pathogenic Proteobacteria. ComP is a type IV minor pilin -site on the minor type IV pilin, C one of three minor (low abundance) pilins in pathogenic Proteobacteria Neisseria species (with PilV and PilX). These modulate Tfp-mediated properties without affecting Tfp biogenesis. ComP plays a prominent role in competence at the level of DNA uptake. Comp is exposed on the surface of Neisseria filaments, and it is this that recognizes homotypic DNA through genus-specific DNA uptake sequence (DUS) motifs.


Pssm-ID: 435546  Cd Length: 83  Bit Score: 48.46  E-value: 1.15e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 919193724   35 YIMVSRRADAVESLFTLSQQLERQFTQSNSYTGLSLATS------SSGGFYTISA 83
Cdd:pfam16732   1 YVLKSRRADAKAALLEAAQAQERYYTQNGTYADLTALGDlassptSGNGYYTISL 55
PRK10574 PRK10574
putative major pilin subunit; Provisional
 8-36 1.39e-08

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 49.65  E-value: 1.39e-08
                         10        20
                 ....*....|....*....|....*....
gi 919193724   8 GFSLIELMIAITVAGILFAIALPAYQDYI 36
Cdd:PRK10574   6 GFTLIELMVVIAIIAILSAIGIPAYQNYL 34
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 8-29 1.82e-04

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 36.13  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|..
gi 919193724    8 GFSLIELMIAITVAGILFAIAL 29
Cdd:TIGR02532   3 GFTLIELLVVLAILGILALIAL 24
 
Name Accession Description Interval E-value
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
8-126 2.57e-25

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 92.44  E-value: 2.57e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919193724   8 GFSLIELMIAITVAGILFAIALPAYQDYIMVSRRADAVESLFTLSQQLERQFTQSNSYTGLSLA---TSSSGGFYTISAE 84
Cdd:COG4968   11 GFTLIELMIVVAIIGILAAIAIPSYQDYVERARRAEAKAALLELAQAQERYYADNGSYPSALADlglPASTSGYYTISIA 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 919193724  85 itdtAFTLTATATGAQSADslcSTFTLNQRGEKgGSNPQECW 126
Cdd:COG4968   91 ----AAATTYTLTATPQAD---GTLTLDQTGVK-TATGADCW 124
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
8-67 2.64e-13

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 62.03  E-value: 2.64e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 919193724   8 GFSLIELMIAITVAGILFAIALPAYQDYIMVSRRADAVESLFTLSQQLERQFTQSNSYTG 67
Cdd:COG4969    7 GFTLIELMIVVAIIGILAAIAIPAYQDYVARARVSEALALASPLKTAVEECALENGSLPN 66
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 8-80 1.97e-11

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 56.07  E-value: 1.97e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 919193724   8 GFSLIELMIAITVAGILFAIALPAYQDYIMVSRRADAVESLFTLSQQLERQFTQSNSY--TGLSLATSSSGGFYT 80
Cdd:COG2165   12 GFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALERYRLDNGRYpsSLTGLLADVRGGGYL 86
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
8-54 9.65e-11

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 53.70  E-value: 9.65e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 919193724   8 GFSLIELMIAITVAGILFAIALPAYQDYIMVSRRADAVESLFTLSQQ 54
Cdd:COG4970   10 GFTLIELLVVLAILAILAAIAVPSFSSLIARQRLRAAANELAAALRL 56
ComP_DUS pfam16732
Type IV minor pilin ComP, DNA uptake sequence receptor; ComP-DUS is the DNA-uptake sequence ...
 35-83 1.15e-08

Type IV minor pilin ComP, DNA uptake sequence receptor; ComP-DUS is the DNA-uptake sequence receptor of pathogenic Proteobacteria. ComP is a type IV minor pilin -site on the minor type IV pilin, C one of three minor (low abundance) pilins in pathogenic Proteobacteria Neisseria species (with PilV and PilX). These modulate Tfp-mediated properties without affecting Tfp biogenesis. ComP plays a prominent role in competence at the level of DNA uptake. Comp is exposed on the surface of Neisseria filaments, and it is this that recognizes homotypic DNA through genus-specific DNA uptake sequence (DUS) motifs.


Pssm-ID: 435546  Cd Length: 83  Bit Score: 48.46  E-value: 1.15e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 919193724   35 YIMVSRRADAVESLFTLSQQLERQFTQSNSYTGLSLATS------SSGGFYTISA 83
Cdd:pfam16732   1 YVLKSRRADAKAALLEAAQAQERYYTQNGTYADLTALGDlassptSGNGYYTISL 55
PRK10574 PRK10574
putative major pilin subunit; Provisional
 8-36 1.39e-08

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 49.65  E-value: 1.39e-08
                         10        20
                 ....*....|....*....|....*....
gi 919193724   8 GFSLIELMIAITVAGILFAIALPAYQDYI 36
Cdd:PRK10574   6 GFTLIELMVVIAIIAILSAIGIPAYQNYL 34
PulJ COG4795
Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and ...
 8-65 1.21e-05

Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443823 [Multi-domain]  Cd Length: 118  Bit Score: 41.54  E-value: 1.21e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 919193724   8 GFSLIELMIAITVAGIlfaIALPAYQDYIMVSR-------RADAVESLFTLSQQLERQFTQSNSY 65
Cdd:COG4795   10 GFTLLELLVALAIFAL---LLLAAYRGLDSVLRsrerleqQAERLQELQRALALLERDLRQAGPR 71
PilW COG4966
Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];
8-113 1.78e-05

Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];


Pssm-ID: 443992 [Multi-domain]  Cd Length: 158  Bit Score: 41.70  E-value: 1.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919193724   8 GFSLIELMIAITVAGILFAIALPAYQD----YIMVSRRADAVESLFTLSQQLERQFTQSNSYTGLSLATSSSGGFYTISA 83
Cdd:COG4966    6 GFTLVELMVALAIGLIVLAAVLQLFLSsrrsYRTQEALARLQENGRFALDLLSRDLRQAGYFGCASGNGNPNGGASVDIA 85

                         90       100       110
                 ....*....|....*....|....*....|
gi 919193724  84 EITDTAFTLTATATGAQSADSLCSTFTLNQ 113
Cdd:COG4966   86 DDVSVLDVLLDTLGGSGDSTLGASSVTGLG 115
ComGC COG4537
Competence protein ComGC [Mobilome: prophages, transposons];
8-40 2.21e-05

Competence protein ComGC [Mobilome: prophages, transposons];


Pssm-ID: 443603 [Multi-domain]  Cd Length: 108  Bit Score: 40.68  E-value: 2.21e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 919193724   8 GFSLIELMIAITVAGILFAIALPAYQDYIMVSR 40
Cdd:COG4537   13 GFTLIEMLIVLLIISILLLIAVPNLTKQRETAQ 45
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 8-29 6.21e-05

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 37.35  E-value: 6.21e-05
                          10        20
                  ....*....|....*....|..
gi 919193724    8 GFSLIELMIAITVAGILFAIAL 29
Cdd:pfam07963   6 GFTLIELLVALAILAILLAAAL 27
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 8-29 1.82e-04

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 36.13  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|..
gi 919193724    8 GFSLIELMIAITVAGILFAIAL 29
Cdd:TIGR02532   3 GFTLIELLVVLAILGILALIAL 24
typeII_sec_gspG TIGR01710
type II secretion system protein G; This model represents GspG, protein G of the main terminal ...
 8-56 4.31e-03

type II secretion system protein G; This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130771 [Multi-domain]  Cd Length: 134  Bit Score: 34.71  E-value: 4.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 919193724    8 GFSLIELMIAITVAGILFAIALPAYQDYIMVSRRADAVESLFTLSQQLE 56
Cdd:TIGR01710   2 GFTLLEIMVVLVILGLLAALVAPKLFSQADKAKAQVAKAQIKALKNALD 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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