NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|913453034|ref|WP_050432443|]
View 

hypothetical protein [Chondromyces crocatus]

Protein Classification

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase( domain architecture ID 11415519)

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of glycerone phosphate and sn-glycerol-3-phosphate

CATH:  1.10.1040.10|3.40.50.720
EC:  1.1.1.-
Gene Ontology:  GO:0051287|GO:0047952|GO:0009331|GO:0046167|GO:0006072
SCOP:  4000111

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-348 1.19e-72

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 228.38  E-value: 1.19e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034   4 ITVLGAGMMGSALCVPLVDRGHEVRLVGThlDGAIIESLQAGHFHPT--MKLDLPAAIRPYpaEALPAAMEGAELVALGV 81
Cdd:COG0240    3 IAVLGAGSWGTALAKVLARNGHEVTLWGR--DPEVAEEINETRENPRylPGVKLPENLRAT--SDLEEALAGADLVLLAV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  82 SSAGIDWATSQLAPFARPGLPIVMITKGLELREGRLgvLPDRVQRGLPEAVRdtvfPAAIAGPCIAGELARRVPTCVVVT 161
Cdd:COG0240   79 PSQALREVLEQLAPLLPPGAPVVSATKGIEPGTGLL--MSEVIAEELPGALR----IAVLSGPSFAEEVARGLPTAVVVA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 162 GRDAGTLARLAEALRGPYYHVFPCADVIGAEVSAALKNAYAM--GVAFGVGLhekaggvagsvaMHNWESAVFAQAIREM 239
Cdd:COG0240  153 SEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIaaGIADGLGL------------GDNARAALITRGLAEM 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 240 MRVTALLGGDPLTVTGLPGVGDLDVTMNG--GRTGRFGRWLGLGLGVAASVARMeGATLECLEILAVMREGLAAHEArge 317
Cdd:COG0240  221 TRLGVALGARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGKGKSLEEALAEM-GMVAEGVYTAKAVYELAEKLGV--- 296

                        330       340       350
                 ....*....|....*....|....*....|.
gi 913453034 318 lrpgELPLLRQMMAVALDDAPVAMPFERFFA 348
Cdd:COG0240  297 ----EMPITEAVYAVLYEGKSPREAVEALMA 323
 
Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-348 1.19e-72

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 228.38  E-value: 1.19e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034   4 ITVLGAGMMGSALCVPLVDRGHEVRLVGThlDGAIIESLQAGHFHPT--MKLDLPAAIRPYpaEALPAAMEGAELVALGV 81
Cdd:COG0240    3 IAVLGAGSWGTALAKVLARNGHEVTLWGR--DPEVAEEINETRENPRylPGVKLPENLRAT--SDLEEALAGADLVLLAV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  82 SSAGIDWATSQLAPFARPGLPIVMITKGLELREGRLgvLPDRVQRGLPEAVRdtvfPAAIAGPCIAGELARRVPTCVVVT 161
Cdd:COG0240   79 PSQALREVLEQLAPLLPPGAPVVSATKGIEPGTGLL--MSEVIAEELPGALR----IAVLSGPSFAEEVARGLPTAVVVA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 162 GRDAGTLARLAEALRGPYYHVFPCADVIGAEVSAALKNAYAM--GVAFGVGLhekaggvagsvaMHNWESAVFAQAIREM 239
Cdd:COG0240  153 SEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIaaGIADGLGL------------GDNARAALITRGLAEM 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 240 MRVTALLGGDPLTVTGLPGVGDLDVTMNG--GRTGRFGRWLGLGLGVAASVARMeGATLECLEILAVMREGLAAHEArge 317
Cdd:COG0240  221 TRLGVALGARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGKGKSLEEALAEM-GMVAEGVYTAKAVYELAEKLGV--- 296

                        330       340       350
                 ....*....|....*....|....*....|.
gi 913453034 318 lrpgELPLLRQMMAVALDDAPVAMPFERFFA 348
Cdd:COG0240  297 ----EMPITEAVYAVLYEGKSPREAVEALMA 323
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
1-294 6.04e-45

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 156.38  E-value: 6.04e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034   1 MAVITVLGAGMMGSALCVPLVDRGHEVRLVGThlDGAIIESLQAGHFHPTMKLD--LPAAIRPYpaEALPAAMEGAELVA 78
Cdd:PRK00094   1 MMKIAVLGAGSWGTALAIVLARNGHDVTLWAR--DPEQAAEINADRENPRYLPGikLPDNLRAT--TDLAEALADADLIL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  79 LGVSSAGIDWATSQLAPFARPGLPIVMITKGLELREGRLgvLPDRVQRGLPEAVRdtvfPAAIAGPCIAGELARRVPTCV 158
Cdd:PRK00094  77 VAVPSQALREVLKQLKPLLPPDAPIVWATKGIEPGTGKL--LSEVLEEELPDLAP----IAVLSGPSFAKEVARGLPTAV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 159 VVTGRDAGTLARLAEALRGPYYHVFPCADVIGAEVSAALKN--AYAMGVAFGVGLHEKAggvagsvamhnwESAVFAQAI 236
Cdd:PRK00094 151 VIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNviAIAAGIADGLGLGDNA------------RAALITRGL 218

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 913453034 237 REMMRVTALLGGDPLTVTGLPGVGDLDVTMNG--GRTGRFGRWLGLGLGVAASVARM----EGA 294
Cdd:PRK00094 219 AEITRLGVALGANPETFLGLAGLGDLVLTCTSplSRNRRFGLALGQGKSLEEALAEIgmvaEGV 282
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 187-297 1.03e-17

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 78.58  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  187 DVIGAEVSAALKNAYAMGVAFGVGLheKAGgvagsvamHNWESAVFAQAIREMMRVTALLGGDPLTVTGLPGVGDLDVTM 266
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGL--GLG--------DNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTC 70

                          90       100       110
                  ....*....|....*....|....*....|...
gi 913453034  267 NGG--RTGRFGRWLGLGLGVAASVARMeGATLE 297
Cdd:pfam07479  71 TSGlsRNRRFGEALGKGKSLEEAEKEL-GQVAE 102
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 91-279 2.55e-14

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 72.76  E-value: 2.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034   91 SQLAPFARPGLPIVMITKGLELREGRLGVLPDRVQR--GLPEAVrdtvfpaaIAGPCIAGELARRVPTCVVVTGRDAGTL 168
Cdd:TIGR03376 100 KQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEelGIPCGV--------LSGANLANEVAKEKFSETTVGYRDPADF 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  169 ARLAEALRG----PYYHVFPCADVIGAEVSAALKNAYAMGVAFGVGLheKAGGvagsvamhNWESAVFAQAIREMMRVTA 244
Cdd:TIGR03376 172 DVDARVLKAlfhrPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGL--GWGD--------NAKAAVMRRGLLEMIKFAR 241

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 913453034  245 LLGGD-PLTVT-GLPGVGDLDVTMNGGRTGRFGRWLG 279
Cdd:TIGR03376 242 MFFPTgEVTFTfESCGVADLITTCLGGRNFKVGRAFA 278
 
Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-348 1.19e-72

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 228.38  E-value: 1.19e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034   4 ITVLGAGMMGSALCVPLVDRGHEVRLVGThlDGAIIESLQAGHFHPT--MKLDLPAAIRPYpaEALPAAMEGAELVALGV 81
Cdd:COG0240    3 IAVLGAGSWGTALAKVLARNGHEVTLWGR--DPEVAEEINETRENPRylPGVKLPENLRAT--SDLEEALAGADLVLLAV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  82 SSAGIDWATSQLAPFARPGLPIVMITKGLELREGRLgvLPDRVQRGLPEAVRdtvfPAAIAGPCIAGELARRVPTCVVVT 161
Cdd:COG0240   79 PSQALREVLEQLAPLLPPGAPVVSATKGIEPGTGLL--MSEVIAEELPGALR----IAVLSGPSFAEEVARGLPTAVVVA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 162 GRDAGTLARLAEALRGPYYHVFPCADVIGAEVSAALKNAYAM--GVAFGVGLhekaggvagsvaMHNWESAVFAQAIREM 239
Cdd:COG0240  153 SEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIaaGIADGLGL------------GDNARAALITRGLAEM 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 240 MRVTALLGGDPLTVTGLPGVGDLDVTMNG--GRTGRFGRWLGLGLGVAASVARMeGATLECLEILAVMREGLAAHEArge 317
Cdd:COG0240  221 TRLGVALGARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGKGKSLEEALAEM-GMVAEGVYTAKAVYELAEKLGV--- 296

                        330       340       350
                 ....*....|....*....|....*....|.
gi 913453034 318 lrpgELPLLRQMMAVALDDAPVAMPFERFFA 348
Cdd:COG0240  297 ----EMPITEAVYAVLYEGKSPREAVEALMA 323
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
1-294 6.04e-45

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 156.38  E-value: 6.04e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034   1 MAVITVLGAGMMGSALCVPLVDRGHEVRLVGThlDGAIIESLQAGHFHPTMKLD--LPAAIRPYpaEALPAAMEGAELVA 78
Cdd:PRK00094   1 MMKIAVLGAGSWGTALAIVLARNGHDVTLWAR--DPEQAAEINADRENPRYLPGikLPDNLRAT--TDLAEALADADLIL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  79 LGVSSAGIDWATSQLAPFARPGLPIVMITKGLELREGRLgvLPDRVQRGLPEAVRdtvfPAAIAGPCIAGELARRVPTCV 158
Cdd:PRK00094  77 VAVPSQALREVLKQLKPLLPPDAPIVWATKGIEPGTGKL--LSEVLEEELPDLAP----IAVLSGPSFAKEVARGLPTAV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 159 VVTGRDAGTLARLAEALRGPYYHVFPCADVIGAEVSAALKN--AYAMGVAFGVGLHEKAggvagsvamhnwESAVFAQAI 236
Cdd:PRK00094 151 VIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNviAIAAGIADGLGLGDNA------------RAALITRGL 218

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 913453034 237 REMMRVTALLGGDPLTVTGLPGVGDLDVTMNG--GRTGRFGRWLGLGLGVAASVARM----EGA 294
Cdd:PRK00094 219 AEITRLGVALGANPETFLGLAGLGDLVLTCTSplSRNRRFGLALGQGKSLEEALAEIgmvaEGV 282
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 70-291 6.47e-24

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 100.63  E-value: 6.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  70 AMEGAELVALGVSSAGIDWATSQLAPFARPGLPIVMITKGLELREG-RLGVLPDRVQRGLPEAVrdtvfpaaIAGPCIAG 148
Cdd:PRK12439  74 AANCADVVVMGVPSHGFRGVLTELAKELRPWVPVVSLVKGLEQGTNmRMSQIIEEVLPGHPAGI--------LAGPNIAR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 149 ELARRVPTCVVVTGRDAGTLARLAEALRGPYYHVFPCADVIGAEVSAALKNAYAMGVAFGVGLhekagGVAgsvamHNWE 228
Cdd:PRK12439 146 EVAEGYAAAAVLAMPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSL-----GIG-----ENTR 215

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 913453034 229 SAVFAQAIREMMRVTALLGGDPLTVTGLPGVGDLDVTMNG--GRTGRFGRWLGLGLGVAASVARM 291
Cdd:PRK12439 216 AMVIARALREMTKLGVAMGGNPETFAGLAGMGDLIVTCTSqrSRNRHVGEQLGAGKPIDEIIASM 280
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 4-333 1.64e-23

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 99.18  E-value: 1.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034   4 ITVLGAGMMGSALCVPLVDRGHEVRLVGTHLDGA--IIESLQAGHFHPTMKLdlPAAIrpYPAEALPAAMEGAELVALGV 81
Cdd:PRK14618   7 VAVLGAGAWGTALAVLAASKGVPVRLWARRPEFAaaLAAERENREYLPGVAL--PAEL--YPTADPEEALAGADFAVVAV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  82 SSAGIDWATSQLAPfarpGLPIVMITKGLELREGRLgvlpDRVQRGLPEAVRDTVfpAAIAGPCIAGELARRVPTCVVVT 161
Cdd:PRK14618  83 PSKALRETLAGLPR----ALGYVSCAKGLAPDGGRL----SELARVLEFLTQARV--AVLSGPNHAEEIARFLPAATVVA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 162 GRDAGTLARLAEALRGPYYHVFPCADVIGAEVSAALKNAYAMGVAFGVGLHekaggvagsvAMHNWESAVFAQAIREMMR 241
Cdd:PRK14618 153 SPEPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLK----------LGDNAKAALITRGLREMVR 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 242 VTALLGGDPLTVTGLPGVGDLDVTMnggrTGRFGRwlglglGVAASVARMEGATLECLEILAVMREGL---AAHEARGEL 318
Cdd:PRK14618 223 FGVALGAEEATFYGLSGLGDLIATA----TSPHSR------NRAAGEAIVRGVDREHLEAGGKVVEGLytvKALDAWAKA 292

                        330
                 ....*....|....*
gi 913453034 319 RPGELPLLRQMMAVA 333
Cdd:PRK14618 293 HGHDLPIVEAVARVA 307
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 4-293 5.23e-20

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 88.89  E-value: 5.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034   4 ITVLGAGMMGSALCVPLVDRGHEVRLVGTHLdgaiieslqaghfhptmkldlpaairpypAEALPAAMEGAELVALGVSS 83
Cdd:PRK14619   7 IAILGAGAWGSTLAGLASANGHRVRVWSRRS-----------------------------GLSLAAVLADADVIVSAVSM 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  84 AGIDWATSQLAPF-ARPGLPIVMITKGLELREGRlgvlpdrvqrgLPEAVRDTVFP----AAIAGPCIAGELARRVPTCV 158
Cdd:PRK14619  58 KGVRPVAEQVQALnLPPETIIVTATKGLDPETTR-----------TPSQIWQAAFPnhpvVVLSGPNLSKEIQQGLPAAT 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 159 VVTGRDAGTLARLAEALRGPYYHVFPCADVIGAEVSAALKNayAMGVAFGV--GLHEKAggvagsvamhNWESAVFAQAI 236
Cdd:PRK14619 127 VVASRDLAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKN--VIAIAAGVcdGLQLGT----------NAKAALVTRAL 194

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 913453034 237 REMMRVTALLGGDPLTVTGLPGVGDLDVTMNG--GRTGRFGRWLGLGLGVAASVARMEG 293
Cdd:PRK14619 195 PEMIRVGTHLGAQTETFYGLSGLGDLLATCTSplSRNYQVGYGLAQGKSLEQILAELEG 253
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 187-297 1.03e-17

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 78.58  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  187 DVIGAEVSAALKNAYAMGVAFGVGLheKAGgvagsvamHNWESAVFAQAIREMMRVTALLGGDPLTVTGLPGVGDLDVTM 266
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGL--GLG--------DNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTC 70

                          90       100       110
                  ....*....|....*....|....*....|...
gi 913453034  267 NGG--RTGRFGRWLGLGLGVAASVARMeGATLE 297
Cdd:pfam07479  71 TSGlsRNRRFGEALGKGKSLEEAEKEL-GQVAE 102
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 4-164 1.05e-16

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 76.46  E-value: 1.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034    4 ITVLGAGMMGSALCVPLVDRGHEVRLVGThlDGAIIESLQAGHFHPTM--KLDLPAAIRPYPaeALPAAMEGAELVALGV 81
Cdd:pfam01210   2 IAVLGAGSWGTALAKVLADNGHEVRLWGR--DEELIEEINTTHENVRYlpGIKLPENLKATT--DLAEALKGADIIVIVV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034   82 SSAGIDWATSQLAPFARPGLPIVMITKGLELREGRLgvLPDRVQRGLPEAVRDTVfpaaIAGPCIAGELARRVPTCVVVT 161
Cdd:pfam01210  78 PSQALREVLKQLKGLLKPDAILVSLSKGIEPGTLKL--LSEVIEEELGIQPPIAV----LSGPSHAEEVAQGLPTATVIA 151


                  ...
gi 913453034  162 GRD 164
Cdd:pfam01210 152 SKD 154
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 91-279 2.55e-14

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 72.76  E-value: 2.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034   91 SQLAPFARPGLPIVMITKGLELREGRLGVLPDRVQR--GLPEAVrdtvfpaaIAGPCIAGELARRVPTCVVVTGRDAGTL 168
Cdd:TIGR03376 100 KQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEelGIPCGV--------LSGANLANEVAKEKFSETTVGYRDPADF 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  169 ARLAEALRG----PYYHVFPCADVIGAEVSAALKNAYAMGVAFGVGLheKAGGvagsvamhNWESAVFAQAIREMMRVTA 244
Cdd:TIGR03376 172 DVDARVLKAlfhrPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGL--GWGD--------NAKAAVMRRGLLEMIKFAR 241

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 913453034  245 LLGGD-PLTVT-GLPGVGDLDVTMNGGRTGRFGRWLG 279
Cdd:TIGR03376 242 MFFPTgEVTFTfESCGVADLITTCLGGRNFKVGRAFA 278
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 3-265 3.39e-07

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 51.37  E-value: 3.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034   3 VITVLGAGMMGSALCVPLVDRGHEVRLVGThlDGAIIESL----QAGHFHPTMKLdlPAAIRPYPA--EALPaamEGAEL 76
Cdd:PRK14620   2 KISILGAGSFGTAIAIALSSKKISVNLWGR--NHTTFESIntkrKNLKYLPTCHL--PDNISVKSAidEVLS---DNATC 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  77 VALGVSSAGIDWATSQLA-PFARPGLPIVMITKGLElregrlgvlpdRVQRGLPEAVRDTVFP----AAIAGPCIAGELA 151
Cdd:PRK14620  75 IILAVPTQQLRTICQQLQdCHLKKNTPILICSKGIE-----------KSSLKFPSEIVNEILPnnpiAILSGPSFAKEIA 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 152 RRVPTCVVVTGRDAGTLARLAEALRGPYYHVFPCADVIGAEVSAALKNAYAmgVAFGVglhekaggVAGSVAMHNWESAV 231
Cdd:PRK14620 144 EKLPCSIVLAGQNETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIA--IACGI--------VLGKNLGNNAHAAV 213

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 913453034 232 FAQAIREMMRVTALLGG--DPLTVTGLPGVGDLDVT 265
Cdd:PRK14620 214 ITKGMNEIKTLYSAKNGsiDLNTLIGPSCLGDLILT 249
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 49-276 1.60e-06

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 49.25  E-value: 1.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034  49 PTMKLdlPAAIRPYPAeaLPAAMEGAELVALGVSSAGIDWATSQLAPFA--RPGLPIVMITKGLELREGRLGVLPDRVQR 126
Cdd:PTZ00345  73 PGIKL--PDNIVAVSD--LKEAVEDADLLIFVIPHQFLESVLSQIKENNnlKKHARAISLTKGIIVENGKPVLCSDVIEE 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034 127 GLpeavrdTVFPAAIAGPCIAGELARRVPTCVVVTGRDAGTLARLAEALRGPYYHVFPCADVIGAEVSAALKNAYAMGVA 206
Cdd:PTZ00345 149 EL------GIPCCALSGANVANDVAREEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAG 222

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 913453034 207 FGVGLHekaggvAGSvamhNWESAVFAQAIREMMRVTALLGGDPLTVTGLP--GVGDLDVTMNGGRTGRFGR 276
Cdd:PTZ00345 223 FCDGLG------LGT----NTKSAIIRIGLEEMKLFGKIFFPNVMDETFFEscGLADLITTCLGGRNVRCAA 284
PRK08229 PRK08229
2-dehydropantoate 2-reductase; Provisional
 1-124 1.81e-03

2-dehydropantoate 2-reductase; Provisional


Pssm-ID: 236193 [Multi-domain]  Cd Length: 341  Bit Score: 39.60  E-value: 1.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034   1 MAVITVLGAGMMGSALCVPLVDRGHEVRLVGThldGAIIESLQAGHFHPTmklDLPAAIRPYPAEAL-----PAAMEGAE 75
Cdd:PRK08229   2 MARICVLGAGSIGCYLGGRLAAAGADVTLIGR---ARIGDELRAHGLTLT---DYRGRDVRVPPSAIafstdPAALATAD 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 913453034  76 LVALGVSSAGIDWATSQLAPFARPGLPIVMITKGLE----LREGrlgvLPDRV 124
Cdd:PRK08229  76 LVLVTVKSAATADAAAALAGHARPGAVVVSFQNGVRnadvLRAA----LPGAT 124
PanE COG1893
Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of ...
 4-104 4.67e-03

Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441497 [Multi-domain]  Cd Length: 305  Bit Score: 38.30  E-value: 4.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913453034   4 ITVLGAGMMGSALCVPLVDRGHEVRLVGthlDGAIIESLQAGHFHPTMKLDLPAAIRPyPAEALPAAMEGAELVALGVSS 83
Cdd:COG1893    3 IAILGAGAIGGLLGARLARAGHDVTLVA---RGAHAEALRENGLRLESPDGDRTTVPV-PAVTDPEELGPADLVLVAVKA 78

                         90       100
                 ....*....|....*....|.
gi 913453034  84 AGIDWATSQLAPFARPGLPIV 104
Cdd:COG1893   79 YDLEAAAEALAPLLGPDTVVL 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH