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Conserved domains on  [gi|906866565|ref|WP_049724995|]
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SET domain-containing protein [Wenzhouxiangella marina]

Protein Classification

SET domain-containing protein( domain architecture ID 11459262)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
8-107 1.75e-27

SET domain-containing protein (function unknown) [General function prediction only];


:

Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 97.72  E-value: 1.75e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565   8 QNPKAYVAESEIHGRGLFARHRIGRDEYIGSYQGPATQDDGMHVLW----------IWNEERERWEGIDGKNEMRFLNHD 77
Cdd:COG2940    4 LHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREphkeplhtylFELDDDGVIDGALGGNPARFINHS 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 906866565  78 AEPNADWWGTD----LFAIRDIEADEEITFDYGW 107
Cdd:COG2940   84 CDPNCEADEEDgrifIVALRDIAAGEELTYDYGL 117
 
Name Accession Description Interval E-value
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
8-107 1.75e-27

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 97.72  E-value: 1.75e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565   8 QNPKAYVAESEIHGRGLFARHRIGRDEYIGSYQGPATQDDGMHVLW----------IWNEERERWEGIDGKNEMRFLNHD 77
Cdd:COG2940    4 LHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREphkeplhtylFELDDDGVIDGALGGNPARFINHS 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 906866565  78 AEPNADWWGTD----LFAIRDIEADEEITFDYGW 107
Cdd:COG2940   84 CDPNCEADEEDgrifIVALRDIAAGEELTYDYGL 117
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 10-107 6.37e-17

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 70.44  E-value: 6.37e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565    10 PKAYVAESEIHGRGLFARHRIGRDEYIGSYQG-----PATQDDGMHVLWIWNEERERWEG-----IDGK---NEMRFLNH 76
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGeiitsEEAEERPKAYDTDGAKAFYLFDIdsdlcIDARrkgNLARFINH 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 906866565    77 DAEPNA---DWWGTD-----LFAIRDIEADEEITFDYGW 107
Cdd:smart00317  81 SCEPNCellFVEVNGddrivIFALRDIKPGEELTIDYGS 119
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 21-106 1.13e-15

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 67.16  E-value: 1.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565   21 GRGLFARHRIGRDEYIGSYQGPA-----------TQDDGMHVLWIWNE-----ERERWEGIDGK-----NEMRFLNHDAE 79
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLlitkeeadkreLLYYDKLELRLWGPylftlDEDSEYCIDARalyygNWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 906866565   80 PNA----DWWGTD----LFAIRDIEADEEITFDYG 106
Cdd:pfam00856  81 PNCevrvVYVNGGprivIFALRDIKPGEELTIDYG 115
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 11-106 8.91e-13

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 59.56  E-value: 8.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  11 KAYVAESEIHGRGLFARHRIGRDEYIGSYQGP-ATQD---------DGMHVLWIWNEERERWegIDGK---NEMRFLNHD 77
Cdd:cd10519    2 RLLLGKSDVAGWGLFLKEPIKKDEFIGEYTGElISQDeadrrgkiyDKYNSSYLFNLNDQFV--VDATrkgNKIRFANHS 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 906866565  78 AEPN--------ADWWGTDLFAIRDIEADEEITFDYG 106
Cdd:cd10519   80 SNPNcyakvmmvNGDHRIGIFAKRDIEAGEELFFDYG 116
 
Name Accession Description Interval E-value
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
8-107 1.75e-27

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 97.72  E-value: 1.75e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565   8 QNPKAYVAESEIHGRGLFARHRIGRDEYIGSYQGPATQDDGMHVLW----------IWNEERERWEGIDGKNEMRFLNHD 77
Cdd:COG2940    4 LHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREphkeplhtylFELDDDGVIDGALGGNPARFINHS 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 906866565  78 AEPNADWWGTD----LFAIRDIEADEEITFDYGW 107
Cdd:COG2940   84 CDPNCEADEEDgrifIVALRDIAAGEELTYDYGL 117
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 10-107 6.37e-17

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 70.44  E-value: 6.37e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565    10 PKAYVAESEIHGRGLFARHRIGRDEYIGSYQG-----PATQDDGMHVLWIWNEERERWEG-----IDGK---NEMRFLNH 76
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGeiitsEEAEERPKAYDTDGAKAFYLFDIdsdlcIDARrkgNLARFINH 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 906866565    77 DAEPNA---DWWGTD-----LFAIRDIEADEEITFDYGW 107
Cdd:smart00317  81 SCEPNCellFVEVNGddrivIFALRDIKPGEELTIDYGS 119
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 21-106 1.13e-15

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 67.16  E-value: 1.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565   21 GRGLFARHRIGRDEYIGSYQGPA-----------TQDDGMHVLWIWNE-----ERERWEGIDGK-----NEMRFLNHDAE 79
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLlitkeeadkreLLYYDKLELRLWGPylftlDEDSEYCIDARalyygNWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 906866565   80 PNA----DWWGTD----LFAIRDIEADEEITFDYG 106
Cdd:pfam00856  81 PNCevrvVYVNGGprivIFALRDIKPGEELTIDYG 115
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 11-106 8.91e-13

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 59.56  E-value: 8.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  11 KAYVAESEIHGRGLFARHRIGRDEYIGSYQGP-ATQD---------DGMHVLWIWNEERERWegIDGK---NEMRFLNHD 77
Cdd:cd10519    2 RLLLGKSDVAGWGLFLKEPIKKDEFIGEYTGElISQDeadrrgkiyDKYNSSYLFNLNDQFV--VDATrkgNKIRFANHS 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 906866565  78 AEPN--------ADWWGTDLFAIRDIEADEEITFDYG 106
Cdd:cd10519   80 SNPNcyakvmmvNGDHRIGIFAKRDIEAGEELFFDYG 116
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 13-106 1.12e-12

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 58.42  E-value: 1.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  13 YVAESEIHGRGLFARHRIGRDEYIGsyqgpatqddgmhvlwiwneererwegidgknEMRFLNHDAEPNA--DWWGTD-- 88
Cdd:cd08161    3 RPSTIPGAGFGLFATRDIPKGEVIG--------------------------------LARFINHSCEPNCefEEVYVGgk 50

                         90       100
                 ....*....|....*....|..
gi 906866565  89 ----LFAIRDIEADEEITFDYG 106
Cdd:cd08161   51 prvfIVALRDIKAGEELTVDYG 72
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 21-106 2.50e-12

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 58.89  E-value: 2.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  21 GRGLFARHRIGRDEYIGSYQG------PATQDDGMHVLWIWNEERERWEG-IDGK---NEMRFLNHDAEPNAD------- 83
Cdd:cd10522   14 GLGLFAAETIAKGEFVGEYTGevldrwEEDRDSVYHYDPLYPFDLNGDILvIDAGkkgNLTRFINHSDQPNLElivrtlk 93

                         90       100
                 ....*....|....*....|....
gi 906866565  84 -WWGTDLFAIRDIEADEEITFDYG 106
Cdd:cd10522   94 gEQHIGFVAIRDIKPGEELFISYG 117
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 13-105 3.70e-12

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 58.76  E-value: 3.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  13 YVAESEIHGRGLFARHRIGRD----EYIGSYQGPATQDdgmhvlwiwneERERW---EG--------IDGK--------- 68
Cdd:cd10518   17 RVGKSGIHGWGLFAKRPIAAGemviEYVGEVIRPIVAD-----------KREKRydeEGgggtymfrIDEDlvidatkkg 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 906866565  69 NEMRFLNHDAEPN-------ADwwGTD---LFAIRDIEADEEITFDY 105
Cdd:cd10518   86 NIARFINHSCDPNcyakiitVD--GEKhivIFAKRDIAPGEELTYDY 130
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 69-107 1.21e-10

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 54.57  E-value: 1.21e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 906866565  69 NEMRFLNHDAEPNADW--WGTD------LFAIRDIEADEEITFDYGW 107
Cdd:cd10531   72 NLSRFINHSCEPNCETqkWIVNgeyrigIFALRDIPAGEELTFDYNF 118
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 65-107 2.84e-09

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 51.14  E-value: 2.84e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 906866565  65 IDGK---NEMRFLNHDAEPNAD---W-----WGTDLFAIRDIEADEEITFDYGW 107
Cdd:cd19174   64 IDGYrmgNEARFVNHSCDPNCEmqkWsvngvYRIGLFALKDIPAGEELTYDYNF 117
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 14-105 2.99e-09

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 51.24  E-value: 2.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  14 VAESEIHGRGLFARHRIGRDEYIGSYQGPATQDdgmhvlwIWNEERER-WEG---------IDGK---------NEMRFL 74
Cdd:cd19170   18 VYRSPIHGRGLFCKRNIDAGEMVIEYAGEVIRS-------VLTDKREKyYESkgigcymfrIDDDevvdatmhgNAARFI 90

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 906866565  75 NHDAEPNA-----DWWGTD---LFAIRDIEADEEITFDY 105
Cdd:cd19170   91 NHSCEPNCysrvvNIDGKKhivIFALRRILRGEELTYDY 129
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 72-106 4.10e-09

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 50.74  E-value: 4.10e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 906866565  72 RFLNHDAEPNADWWGTD-----LFAIRDIEADEEITFDYG 106
Cdd:cd10524   78 AFINHDCRPNCKFVPTGkstacVKVLRDIEPGEEITVYYG 117
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 13-106 1.77e-08

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 48.40  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  13 YVAESEIHGRGLFARHRIGRDEYIgsyqgpatqdDGMHVLWIWNEERE--RWEGID-----GKNEMRFL--------NHD 77
Cdd:cd10540    3 EVKPSTLKGRGVFATRPIKKGEVI----------EEAPVIVLPKEEYQhlCKTVLDhyvfsWGDGCLALalgygsmfNHS 72

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 906866565  78 AEPNADWWGT------DLFAIRDIEADEEITFDYG 106
Cdd:cd10540   73 YTPNAEYEIDfenqtiVFYALRDIEAGEELTINYG 107
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 14-106 2.18e-08

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 48.72  E-value: 2.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  14 VAESEIH-GRGLFARHRIGRDEYIGSYQGPATQDD-GM---HVLWIWN-----EERERWEgIDG---KNEMRFLNHdAEP 80
Cdd:cd19168    5 LGKSQLEcGLGLFAAEDIKEGEFVIEYTGELISHDeGVrreHRRGDVSylylfEEQEGIW-VDAaiyGNLSRYINH-ATD 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 906866565  81 NADW-------------WGTDLFAIRDIEADEEITFDYG 106
Cdd:cd19168   83 KVKTgncmpkimyvnheWRIKFTAIKDIKIGEELFFNYG 121
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 69-105 5.68e-08

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 47.58  E-value: 5.68e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 906866565  69 NEMRFLNHDAEPNA--DWWGTD------LFAIRDIEADEEITFDY 105
Cdd:cd19172   74 NLSRFINHSCEPNCetQKWTVNgelrvgFFAKRDIPAGEELTFDY 118
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 14-105 1.20e-07

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 47.32  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  14 VAESEIHGRGLFARHRIGRDEYIGSYQGPATQDdgmhvlwIWNEERERW----------------EGIDGK---NEMRFL 74
Cdd:cd19206   18 VYRSPIHGRGLFCKRNIDAGEMVIEYSGNVIRS-------ILTDKREKYydskgigcymfriddsEVVDATmhgNAARFI 90

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 906866565  75 NHDAEPN--ADWWGTD------LFAIRDIEADEEITFDY 105
Cdd:cd19206   91 NHSCEPNcySRVINIDgqkhivIFAMRKIYRGEELTYDY 129
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 16-105 2.76e-07

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 45.87  E-value: 2.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  16 ESEIHGRGLFARHRIGRDEYIGSYQGPATQDDGMHV-LWIWNE---------ERERWEGIDGK---NEMRFLNHDAEPNA 82
Cdd:cd19175    6 KTEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEErLWDMKHkgeknfymcEIDKDMVIDATfkgNLSRFINHSCDPNC 85

                         90       100       110
                 ....*....|....*....|....*....|.
gi 906866565  83 DW--WGTD------LFAIRDIEADEEITFDY 105
Cdd:cd19175   86 ELqkWQVDgetrigVFAIRDIKKGEELTYDY 116
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 73-106 3.34e-07

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 45.45  E-value: 3.34e-07
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 906866565  73 FLNHDAEPNADWWGTD-----LFAIRDIEADEEITFDYG 106
Cdd:cd20071   58 LLNHSCDPNAVVVFDGngtlrVRALRDIKAGEELTISYI 96
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 65-106 3.80e-07

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 46.60  E-value: 3.80e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 906866565  65 IDGK---NEMRFLNHDAEPN-------ADwwGTD-------LFAIRDIEADEEITFDYG 106
Cdd:cd10538  161 VDATfcgNVSRFINHSCDPNlfpfnvvID--HDDlrypriaLFATRDILPGEELTFDYG 217
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 69-105 5.06e-07

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 46.13  E-value: 5.06e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 906866565  69 NEMRFLNHDAEPN----ADWWGT--------DLFAIRDIEADEEITFDY 105
Cdd:cd10542  163 NISHFINHSCDPNlavyAVWINHldprlpriAFFAKRDIKAGEELTFDY 211
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 10-105 8.11e-07

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 44.60  E-value: 8.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  10 PKAYVAESEIHGRGLFARHRIGRDEYIGSYQGP-------------ATQDDGMHvLWIWNEERERWegIDGK---NEMRF 73
Cdd:cd19211    2 PETKIIKTEGKGWGLIAKRDIKKGEFVNEYVGElideeecmarikhAHENDITH-FYMLTIDKDRI--IDAGpkgNYSRF 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 906866565  74 LNHDAEPNADW--WGTD------LFAIRDIEADEEITFDY 105
Cdd:cd19211   79 MNHSCQPNCETqkWTVNgdtrvgLFAVCDIPAGTELTFNY 118
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 69-107 8.32e-07

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 44.61  E-value: 8.32e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 906866565  69 NEMRFLNHDAEPN--ADWWGTD------LFAIRDIEADEEITFDYGW 107
Cdd:cd19173   74 NLSRFMNHSCQPNceTQKWTVNgdtrvgLFAVRDIPAGEELTFNYNL 120
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 72-106 1.71e-06

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 44.98  E-value: 1.71e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 906866565  72 RFLNHDAEPN---------------AdwwgtdLFAIRDIEADEEITFDYG 106
Cdd:cd10544  171 RFLNHSCEPNlfmvpvrvdsmvpklA------LFAARDIVAGEELSFDYS 214
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 72-105 2.41e-06

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 44.62  E-value: 2.41e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 906866565  72 RFLNHDAEPN----------ADWWGTDL--FAIRDIEADEEITFDY 105
Cdd:cd19473  195 RFINHSCDPNlrifarvgdhADKHIHDLafFAIKDIPRGTELTFDY 240
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 15-105 9.29e-06

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 41.94  E-value: 9.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  15 AESEIHGRGLFARHRIGRDEYIGSYQGPAtqddgmhVLWIWNEERE-RWE--GIDGK-----------------NEMRFL 74
Cdd:cd19169   18 AKSRIHDWGLFALEPIAADEMVIEYVGQV-------IRQSVADEREkRYEaiGIGSSylfrvdddtiidatkcgNLARFI 90

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 906866565  75 NHDAEPN--------ADWWGTDLFAIRDIEADEEITFDY 105
Cdd:cd19169   91 NHSCNPNcyakiitvESQKKIVIYSKRPIAVNEEITYDY 129
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 14-105 2.53e-05

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 40.78  E-value: 2.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  14 VAESEIHGRGLFARHRIGRDEYIGSYQGPATQDdgmhvlwIWNEERERWegIDGK---------------------NEMR 72
Cdd:cd19207   18 VYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRS-------VLTDKREKF--YDSKgigcymfriddfdvvdatmhgNAAR 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 906866565  73 FLNHDAEPNA--------DWWGTDLFAIRDIEADEEITFDY 105
Cdd:cd19207   89 FINHSCEPNCysrvihveGQKHIVIFALRKIYRGEELTYDY 129
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 65-106 3.36e-05

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 41.17  E-value: 3.36e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 906866565  65 IDGK---NEMRFLNHDAEPN-------ADwwGTDL-------FAIRDIEADEEITFDYG 106
Cdd:cd10543  152 IDARrygNISRFINHLCEPNlipvrvfVE--HQDLrfpriafFASRDIKAGEELGFDYG 208
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 40-105 8.71e-05

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 39.86  E-value: 8.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  40 QGPATQDDGMHVLW---IWNEERERWEGIDGKN---EMRFLNHDAEPN------------ADWWGTDLFAIRDIEADEEI 101
Cdd:cd20073  135 RGKKYDNVGVTYLFdldLFEDQVDEYYTVDAQYcgdVTRFINHSCDPNlaiysvlrdksdSKIYDLAFFAIKDIPALEEL 214


                 ....
gi 906866565 102 TFDY 105
Cdd:cd20073  215 TFDY 218
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 21-105 1.21e-04

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 38.76  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  21 GRGLFARHRIGRDEYIGSYQGPA------------TQDDGMHVLWIWNEERERWegIDGK---NEMRFLNHDAEPNADW- 84
Cdd:cd19210   13 GWGLRCKTDIKKGEFVNEYVGELideeecrariryAQEHDITNFYMLTLDKDRI--IDAGpkgNYARFMNHCCQPNCETq 90

                         90       100
                 ....*....|....*....|....*...
gi 906866565  85 -WGTD------LFAIRDIEADEEITFDY 105
Cdd:cd19210   91 kWTVNgdtrvgLFALCDIKAGTELTFNY 118
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 73-106 1.82e-04

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 38.97  E-value: 1.82e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 906866565  73 FLNHDAE-PNADWWGTD------LFAIRDIEADEEITFDYG 106
Cdd:cd10527  182 MLNHSPDaPNVRYEYDEdegsfvLVATRDIAAGEEVFISYG 222
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 65-107 7.76e-04

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 37.27  E-value: 7.76e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 906866565  65 IDGK---NEMRFLNHDAEPNAD----WWGT-DL-------FAIRDIEADEEITFDYGW 107
Cdd:cd10517  207 IDAKsegNLGRYLNHSCSPNLFvqnvFVDThDLrfpwvafFASRYIRAGTELTWDYNY 264
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 73-106 8.18e-04

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 37.28  E-value: 8.18e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 906866565  73 FLNHDAEPNAD--WWGTD--LFAIRDIEADEEITFDYG 106
Cdd:cd10536  153 LLNHSCDPNTIrsFYGNTivVRATRPIKKGEEITICYG 190
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 15-105 8.35e-04

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 36.63  E-value: 8.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  15 AESEIHGRGLFARHRIGRDEYIGSYQGPATQDDgmhvlwiWNEERERW---EGIDGK-----------------NEMRFL 74
Cdd:cd20072   18 ARSAIHNWGLYAMENISAKDMVIEYVGEVIRQQ-------VADEREKRylrQGIGSSylfridddtvvdatkkgNIARFI 90

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 906866565  75 NHDAEPN--ADWWGTD------LFAIRDIEADEEITFDY 105
Cdd:cd20072   91 NHCCDPNctAKIIKVEgekrivIYAKRDIAAGEELTYDY 129
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 10-105 1.09e-03

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 36.44  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  10 PKAYVAESEIHGRGLFARHRIGRDEYIGSYQGPA------------TQDDGMHVLWIWNEERERWegIDGK---NEMRFL 74
Cdd:cd19212    2 PDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELideeecrlrikrAHENSVTNFYMLTVTKDRI--IDAGpkgNYSRFM 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 906866565  75 NHDAEPNADW--WGTD------LFAIRDIEADEEITFDY 105
Cdd:cd19212   80 NHSCNPNCETqkWTVNgdvrvgLFALCDIPAGMELTFNY 118
SET_KMT5C cd19185
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) ...
 73-106 1.11e-03

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins; KMT5C (also termed lysine N-methyltransferase 5C, lysine-specific methyltransferase 5C, suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 or Suv4-20h2) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380962  Cd Length: 142  Bit Score: 36.17  E-value: 1.11e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 906866565  73 FLNHDAEPNADWWGTD-----LFAIRDIEADEEITFDYG 106
Cdd:cd19185   79 FINHDCKPNCKFVPADgnaacVKVLRDIEPGDEVTCFYG 117
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 34-106 1.60e-03

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 36.45  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  34 EYIGSYQGPATQD---DGMHVLWIWNEERERWeGIDGK---NEMRFLNHDAEPN-----ADWWGTDL-------FAIRDI 95
Cdd:cd10535  119 EYVGELISDSEADvreEDSYLFDLDNKDGEVY-CIDARfygNVSRFINHHCEPNlvpvrVFMAHQDLrfpriafFSTRLI 197

                         90
                 ....*....|.
gi 906866565  96 EADEEITFDYG 106
Cdd:cd10535  198 EAGEQLGFDYG 208
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 69-107 1.85e-03

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 35.84  E-value: 1.85e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 906866565  69 NEMRFLNHDAEPNADW------WGTD----LFAIRDIEADEEITFDYGW 107
Cdd:cd19183   76 SVARFIRRSCRPNAELvtvasdSGSVlkfvLYASRDISPGEEITIGWDW 124
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 17-105 5.61e-03

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 34.61  E-value: 5.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  17 SEIHGRGLFARHRIGRDEYIGSYQGPATQddgmHVLWIWNEERERWEGIDGK-----------------NEMRFLNHDAE 79
Cdd:cd19204   21 SRIHEWGLFAMEPIAADEMVIEYVGQNIR----QVVADMREKRYVQEGIGSSylfrvdhdtiidatkcgNLARFINHCCT 96

                         90       100       110
                 ....*....|....*....|....*....|....
gi 906866565  80 PNA--------DWWGTDLFAIRDIEADEEITFDY 105
Cdd:cd19204   97 PNCyakvitieSQKKIVIYSKQPIGVNEEITYDY 130
SET_Suv4-20 cd19186
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 73-106 6.06e-03

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation.


Pssm-ID: 380963  Cd Length: 142  Bit Score: 34.35  E-value: 6.06e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 906866565  73 FLNHDAEPNADWWGTD-----LFAIRDIEADEEITFDYG 106
Cdd:cd19186   80 FINHDCRPNCKFVSTGrdtacVQVLRDIEPGEEITCFYG 118
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 14-105 7.85e-03

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 33.89  E-value: 7.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 906866565  14 VAESEIHGRGLFARHRIGRDEYIGSYQGP-ATQDDGMHVLWIWNEERERW----------EGIDGKNEMRFLNHDAEPNA 82
Cdd:cd19217   10 LAPSDVAGWGTFIKESVQKNEFISEYCGElISQDEADRRGKVYDKYMSSFlfnlnndfvvDATRKGNKIRFANHSVNPNC 89

                         90       100       110
                 ....*....|....*....|....*....|.
gi 906866565  83 --------DWWGTDLFAIRDIEADEEITFDY 105
Cdd:cd19217   90 yakvvmvnGDHRIGIFAKRAIQQGEELFFDY 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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