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Conserved domains on  [gi|902711437|ref|WP_049626879|]
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MMPL family transporter [Meiothermus ruber]

Protein Classification

MMPL family transporter( domain architecture ID 11457272)

MMPL family transporter similar to mycobacterial membrane protein large (MMPL) transporters, which function in the export of lipid components across the cell envelope; belongs to a subfamily of the resistance-nodulation-cell division (RND) permeases

Gene Ontology:  GO:0016020|GO:0005215
PubMed:  10941792|28340510
TCDB:  2.A.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 27-685 2.13e-124

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


:

Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 386.81  E-value: 2.13e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  27 AIPAARLAPQNLAANASAVKNSEAQKVLQILTEAFGLPPVDRTVLVSES-SLPEHDPRFRQTYNQLMARMQTLEGVLRIH 105
Cdd:COG2409   19 LGVLAPQLGGSLSSNGFFLPGSESQRAADLLAEAFPESDGASAVVVVEApDGTLTDPAFRAAVAALVARLRADPGVAGVQ 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 106 RYDAPSPLQQQSQDGK---ITATLLDTRLENGEAVIEALRREARAAQTPEIRFYVTGATAVTKDFLHLLEADVKRSELMA 182
Cdd:COG2409   99 DPWDDPAAGLVSEDGKaalVTVTLDGDAGDEAAEAVDALRDAVAAAPAPGLTVYVTGPAALAADLNEAFEEDLGRAELIT 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 183 LPLTGLVLLLAFGALVATGLPLLVGVVAITTGLACLFFLTLWGEVSSFALSVITMLS------------------LGAGM 244
Cdd:COG2409  179 LPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDVSSFAPNLLTMLGlgvgidyalflvsryreeLRAGE 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 245 GGGGGGGGgggggggggggggggggAPQTAGRTVAFSGLVVAIAMGAMLVPDLTFIRSMGVGGVMAITLTVLVSITLLPA 324
Cdd:COG2409  259 DREEAVAR-----------------AVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPA 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 325 LLALLGERVNAPRRWAFKPTSSGKaSPFWGRWASVVMQRPWMWSFGVMGLLLALAWPATQMKLGYTGAFGLGPHVESRKG 404
Cdd:COG2409  322 LLALLGRRVFWPRRPRRRRAAAPE-SGFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPDADSLPADSPSRQG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 405 LELIRQLELGGALDAFEVLLDlGEEGFTPQNRARWRALEQRLSAWPEVRLVVSPFLAGrlegqggfaelvgltnqyiSQD 484
Cdd:COG2409  401 YDALAEHFPPGSNGPLTVVVE-SDDDLDPADLAALDALAAALAAVPGVASVQPPTRPE-------------------GTD 460

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 485 RRYLRLTVIPRDAVHAPSIPDWYARLKQEAQQAGF-QRVLLGGAPVGSMEFTQALVGAMPAAIGTVFVATFLLLAVAFRS 563
Cdd:COG2409  461 GDAARLQVVPDGDPDSPEAIDLVDRLRDAAAPALEgAEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLLLLLFRS 540

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 564 LVIPLKSILMNTLTVGAAYGLITLVFQEGFAarLVGAPTdvGGIDSSLPILMFAVIFGLSMDYEIFLLSRVQEAHLAGLD 643
Cdd:COG2409  541 VVAPLKAVLTNLLSLGAALGVLVLVFQHGWL--LLGFTP--GPLDSFVPLLLFVILFGLGMDYEVFLVSRIREEYDRGGG 616

                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 902711437 644 TPQAVRYALERTAGVIGSAALIMVIVFSAFVVGQVVANKTIG 685
Cdd:COG2409  617 TREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVFLKQIG 658
 
Name Accession Description Interval E-value
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 27-685 2.13e-124

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 386.81  E-value: 2.13e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  27 AIPAARLAPQNLAANASAVKNSEAQKVLQILTEAFGLPPVDRTVLVSES-SLPEHDPRFRQTYNQLMARMQTLEGVLRIH 105
Cdd:COG2409   19 LGVLAPQLGGSLSSNGFFLPGSESQRAADLLAEAFPESDGASAVVVVEApDGTLTDPAFRAAVAALVARLRADPGVAGVQ 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 106 RYDAPSPLQQQSQDGK---ITATLLDTRLENGEAVIEALRREARAAQTPEIRFYVTGATAVTKDFLHLLEADVKRSELMA 182
Cdd:COG2409   99 DPWDDPAAGLVSEDGKaalVTVTLDGDAGDEAAEAVDALRDAVAAAPAPGLTVYVTGPAALAADLNEAFEEDLGRAELIT 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 183 LPLTGLVLLLAFGALVATGLPLLVGVVAITTGLACLFFLTLWGEVSSFALSVITMLS------------------LGAGM 244
Cdd:COG2409  179 LPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDVSSFAPNLLTMLGlgvgidyalflvsryreeLRAGE 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 245 GGGGGGGGgggggggggggggggggAPQTAGRTVAFSGLVVAIAMGAMLVPDLTFIRSMGVGGVMAITLTVLVSITLLPA 324
Cdd:COG2409  259 DREEAVAR-----------------AVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPA 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 325 LLALLGERVNAPRRWAFKPTSSGKaSPFWGRWASVVMQRPWMWSFGVMGLLLALAWPATQMKLGYTGAFGLGPHVESRKG 404
Cdd:COG2409  322 LLALLGRRVFWPRRPRRRRAAAPE-SGFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPDADSLPADSPSRQG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 405 LELIRQLELGGALDAFEVLLDlGEEGFTPQNRARWRALEQRLSAWPEVRLVVSPFLAGrlegqggfaelvgltnqyiSQD 484
Cdd:COG2409  401 YDALAEHFPPGSNGPLTVVVE-SDDDLDPADLAALDALAAALAAVPGVASVQPPTRPE-------------------GTD 460

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 485 RRYLRLTVIPRDAVHAPSIPDWYARLKQEAQQAGF-QRVLLGGAPVGSMEFTQALVGAMPAAIGTVFVATFLLLAVAFRS 563
Cdd:COG2409  461 GDAARLQVVPDGDPDSPEAIDLVDRLRDAAAPALEgAEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLLLLLFRS 540

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 564 LVIPLKSILMNTLTVGAAYGLITLVFQEGFAarLVGAPTdvGGIDSSLPILMFAVIFGLSMDYEIFLLSRVQEAHLAGLD 643
Cdd:COG2409  541 VVAPLKAVLTNLLSLGAALGVLVLVFQHGWL--LLGFTP--GPLDSFVPLLLFVILFGLGMDYEVFLVSRIREEYDRGGG 616

                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 902711437 644 TPQAVRYALERTAGVIGSAALIMVIVFSAFVVGQVVANKTIG 685
Cdd:COG2409  617 TREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVFLKQIG 658
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 46-364 1.29e-15

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 78.87  E-value: 1.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437   46 KNSEAQKVLQILTEAFGLPPVD--RTVLVSESSLPEHDPRFRQTYNQLMARMQTLEGVLrIHRYDAPS-PL---QQQSQD 119
Cdd:pfam03176   5 ADAPSVRAMDRLGAAFPQADSDpiIVVVLGEGDQALGDAAAEAGYDTLVDALRADTGHV-GSVQDFWGdPDtaaLFVSPD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  120 GKITATLLDTRLENGE----AVIEALRREARAAQTPE-IRFYVTGATAVTKDFLHLLEADVKRSELMALPLTGLVLLLAF 194
Cdd:pfam03176  84 GKAAYVVVTLEGDPGTteadESVAAVRDAVEQAPPPEgLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIVY 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  195 GALVATGLPLL-VGV-VAITTGLACLFFLTLWGEVSSFALSVITMLSLGAGM-GGGGGGGGGGGGGGGGGGGGGGGGGAP 271
Cdd:pfam03176 164 RSVVAALLPLLtVGLsLGAAQGLVAILAHILGIGLSTFALNLLVVLLIAVGTdYALFLVSRYREELRAGEDREEAVIRAV 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  272 QTAGRTVAFSGLVVAIAMGAMLVPDLTFIRSMGVGGVMAITLTVLVSITLLPALLALLGervnaprRWAFKPTSSGKASP 351
Cdd:pfam03176 244 RGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLG-------RWGLWPPKRDRTAR 316

                         330
                  ....*....|...
gi 902711437  352 FWGRWASVVMQRP 364
Cdd:pfam03176 317 WWRRIGRLVVRRP 329
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 544-717 4.75e-11

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 66.53  E-value: 4.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  544 AAIGTVFVatFLLLAVAFRSLVIPLKSILMNTLTVGAAYGLITLVFQEGFAArlvgaptdvgGIDSSLPILMFAVIFGLS 623
Cdd:TIGR00833 750 SIITLAIV--FMILALLLRAPVAPIVLIGSVALSYLWALGLSVLAFQHILGA----------ELHWSVLAGVFVLLVALG 817

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  624 MDYEIFLLSRVQEAHLAGLDTPqaVRYALERTAGVIGSAALIMVIVFSAFVVGQVVANKTIGLGLALAVLLDATLVRLVL 703
Cdd:TIGR00833 818 VDYNMLLVSRIKEESPAGNRTG--IIRALGSTGGVITAAGLVFAGTMAALASAQLTAIAQFGFTVGVGILLDTFIVRSVT 895

                         170
                  ....*....|....
gi 902711437  704 VPAVLVLAGRWNWW 717
Cdd:TIGR00833 896 VPALTLLLGRWIWW 909
 
Name Accession Description Interval E-value
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 27-685 2.13e-124

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 386.81  E-value: 2.13e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  27 AIPAARLAPQNLAANASAVKNSEAQKVLQILTEAFGLPPVDRTVLVSES-SLPEHDPRFRQTYNQLMARMQTLEGVLRIH 105
Cdd:COG2409   19 LGVLAPQLGGSLSSNGFFLPGSESQRAADLLAEAFPESDGASAVVVVEApDGTLTDPAFRAAVAALVARLRADPGVAGVQ 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 106 RYDAPSPLQQQSQDGK---ITATLLDTRLENGEAVIEALRREARAAQTPEIRFYVTGATAVTKDFLHLLEADVKRSELMA 182
Cdd:COG2409   99 DPWDDPAAGLVSEDGKaalVTVTLDGDAGDEAAEAVDALRDAVAAAPAPGLTVYVTGPAALAADLNEAFEEDLGRAELIT 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 183 LPLTGLVLLLAFGALVATGLPLLVGVVAITTGLACLFFLTLWGEVSSFALSVITMLS------------------LGAGM 244
Cdd:COG2409  179 LPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDVSSFAPNLLTMLGlgvgidyalflvsryreeLRAGE 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 245 GGGGGGGGgggggggggggggggggAPQTAGRTVAFSGLVVAIAMGAMLVPDLTFIRSMGVGGVMAITLTVLVSITLLPA 324
Cdd:COG2409  259 DREEAVAR-----------------AVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPA 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 325 LLALLGERVNAPRRWAFKPTSSGKaSPFWGRWASVVMQRPWMWSFGVMGLLLALAWPATQMKLGYTGAFGLGPHVESRKG 404
Cdd:COG2409  322 LLALLGRRVFWPRRPRRRRAAAPE-SGFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPDADSLPADSPSRQG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 405 LELIRQLELGGALDAFEVLLDlGEEGFTPQNRARWRALEQRLSAWPEVRLVVSPFLAGrlegqggfaelvgltnqyiSQD 484
Cdd:COG2409  401 YDALAEHFPPGSNGPLTVVVE-SDDDLDPADLAALDALAAALAAVPGVASVQPPTRPE-------------------GTD 460

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 485 RRYLRLTVIPRDAVHAPSIPDWYARLKQEAQQAGF-QRVLLGGAPVGSMEFTQALVGAMPAAIGTVFVATFLLLAVAFRS 563
Cdd:COG2409  461 GDAARLQVVPDGDPDSPEAIDLVDRLRDAAAPALEgAEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLLLLLFRS 540

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 564 LVIPLKSILMNTLTVGAAYGLITLVFQEGFAarLVGAPTdvGGIDSSLPILMFAVIFGLSMDYEIFLLSRVQEAHLAGLD 643
Cdd:COG2409  541 VVAPLKAVLTNLLSLGAALGVLVLVFQHGWL--LLGFTP--GPLDSFVPLLLFVILFGLGMDYEVFLVSRIREEYDRGGG 616

                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 902711437 644 TPQAVRYALERTAGVIGSAALIMVIVFSAFVVGQVVANKTIG 685
Cdd:COG2409  617 TREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVFLKQIG 658
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
117-685 2.67e-34

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 139.99  E-value: 2.67e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 117 SQDGKITATLL------DTRLENGEAVIEALRREARAAQTPEIRFYVTGATAVTKDFLHLLEADVKRSELMALPLTGLVL 190
Cdd:COG1033  156 SPDGKATLIVVtldpdpLSSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLL 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 191 LLAFGALVATGLPLLVGVVAI--TTGLACLFFLTLwGEVSSFALSVIT---------MLSlgagmgggggggggggGGGG 259
Cdd:COG1033  236 FLFFRSLRGVLLPLLVVLLAViwTLGLMGLLGIPL-SPLTILVPPLLLaigidygihLLN----------------RYRE 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 260 GGGGGGGGGGAPQTA----GRTVAFSGLVVAIAMGAMLVPDLTFIRSMGVGGVMAITLTVLVSITLLPALLALLGERVNA 335
Cdd:COG1033  299 ERRKGLDKREALREAlrklGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPK 378

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 336 PRRwafkPTSSGKASPFWGRWASVVMQRPWMWSFGVMGLLLALAWPATQMKLGYTGAFGLGPHVESRKGLELIRQlELGG 415
Cdd:COG1033  379 TRR----LKKPPELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEE-NFGG 453

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 416 AlDAFEVLLDLGEEG--FTPQNRARWRALEQRLSAWPEVRLVVSP------FLAGRLEGQGGFAEL-------------- 473
Cdd:COG1033  454 S-DPLEVVVDTGEPDglKDPEVLKEIDRLQDYLESLPEVGKVLSLadlvkeLNQALNEGDPKYYALpesrellaqlllll 532

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 474 ----VGLTNQYISQDRRYLRLTVIPRDAvHAPSIPDWYARLKQEAQQ----AGFQrVLLGGAPVGSMEFTQALVGAMPAA 545
Cdd:COG1033  533 ssppGDDLSRFVDEDYSAARVTVRLKDL-DSEEIKALVEEVRAFLAEnfppDGVE-VTLTGSAVLFAAINESVIESQIRS 610

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 546 IGTVFVATFLLLAVAFRSLVIPLKSILMNTLTVGAAYGLItlvfqegfaaRLVGAPTDVGgidsslPILMFAVIFGLSMD 625
Cdd:COG1033  611 LLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLM----------GLLGIPLNIA------TAVVASIALGIGVD 674

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 626 YEIFLLSRVQEAHLAGLDTPQAVRYALERTAGVIGSAALIMVIVFSAFVVGQVVANKTIG 685
Cdd:COG1033  675 YTIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFG 734
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
352-685 6.74e-21

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 98.01  E-value: 6.74e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 352 FWGRWASVVMQRPWMWSFGVMGLLLALAWPATQMKLGYTGAFGLGPHVESRKGLELIRQlELGGALDAFeVLLDLGEEGF 431
Cdd:COG1033    3 LMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEE-EFGGDDTVV-VAVEGKDDIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 432 TPQNRARWRALEQRLSAWPEVRLVVSPFLAGRLEGQGG-------------------------FAELVGLTNQYISQDRR 486
Cdd:COG1033   81 TPETLEALRELTEELEEIPGVDSVTSLTNVRATEGTEDgltveplipdelpaspeelaelrekVLSSPLYVGRLVSPDGK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 487 YLRLTVIPRDAVHAPSIPDW--YARLKQEAQQAGFQ--RVLLGGAPVGSMEFTQALVGAMPAAIGTVFVATFLLLAVAFR 562
Cdd:COG1033  161 ATLIVVTLDPDPLSSDLDRKevVAEIRAIIAKYEDPgvEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 563 SLVIPLksilmntLTVGAAygLITLVFQEGFAArLVGAPTDVggidssLPILMFAVIFGLSMDYEIFLLSRVQEAHLAGL 642
Cdd:COG1033  241 SLRGVL-------LPLLVV--LLAVIWTLGLMG-LLGIPLSP------LTILVPPLLLAIGIDYGIHLLNRYREERRKGL 304

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 902711437 643 DTPQAVRYALERTAGVIGSAALIMVIVFSAFVVGQVVANKTIG 685
Cdd:COG1033  305 DKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFG 347
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 371-685 1.40e-17

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 87.13  E-value: 1.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 371 VMGLLLALAWPATQMKLGYTGAFGlgPHVESRKGLELIRQLELGGALDAFEVLLDLGEEGFT-PQNRARWRALEQRLSAW 449
Cdd:COG2409   14 VLLVALGVLAPQLGGSLSSNGFFL--PGSESQRAADLLAEAFPESDGASAVVVVEAPDGTLTdPAFRAAVAALVARLRAD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 450 PEVRLVVSPFLAGrlegQGGFaelvgltnqyISQDRRYLrLTVIPRDAVHAPSIPDWYARLKQEAQQAGFQ--RVLLGGA 527
Cdd:COG2409   92 PGVAGVQDPWDDP----AAGL----------VSEDGKAA-LVTVTLDGDAGDEAAEAVDALRDAVAAAPAPglTVYVTGP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437 528 PVGSMEFTQALVGAMPAAIGTVFVATFLLLAVAFRSLVIPLKSILMNTLTVGAAYGLITLVfqegfaarlvgapTDVGGI 607
Cdd:COG2409  157 AALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALL-------------AAFTDV 223

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 902711437 608 DSSLPILMFAVIFGLSMDYEIFLLSRVQEAHLAGLDTPQAVRYALERTAGVIGSAALIMVIVFSAFVVGQVVANKTIG 685
Cdd:COG2409  224 SSFAPNLLTMLGLGVGIDYALFLVSRYREELRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMG 301
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 46-364 1.29e-15

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 78.87  E-value: 1.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437   46 KNSEAQKVLQILTEAFGLPPVD--RTVLVSESSLPEHDPRFRQTYNQLMARMQTLEGVLrIHRYDAPS-PL---QQQSQD 119
Cdd:pfam03176   5 ADAPSVRAMDRLGAAFPQADSDpiIVVVLGEGDQALGDAAAEAGYDTLVDALRADTGHV-GSVQDFWGdPDtaaLFVSPD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  120 GKITATLLDTRLENGE----AVIEALRREARAAQTPE-IRFYVTGATAVTKDFLHLLEADVKRSELMALPLTGLVLLLAF 194
Cdd:pfam03176  84 GKAAYVVVTLEGDPGTteadESVAAVRDAVEQAPPPEgLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIVY 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  195 GALVATGLPLL-VGV-VAITTGLACLFFLTLWGEVSSFALSVITMLSLGAGM-GGGGGGGGGGGGGGGGGGGGGGGGGAP 271
Cdd:pfam03176 164 RSVVAALLPLLtVGLsLGAAQGLVAILAHILGIGLSTFALNLLVVLLIAVGTdYALFLVSRYREELRAGEDREEAVIRAV 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  272 QTAGRTVAFSGLVVAIAMGAMLVPDLTFIRSMGVGGVMAITLTVLVSITLLPALLALLGervnaprRWAFKPTSSGKASP 351
Cdd:pfam03176 244 RGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLG-------RWGLWPPKRDRTAR 316

                         330
                  ....*....|...
gi 902711437  352 FWGRWASVVMQRP 364
Cdd:pfam03176 317 WWRRIGRLVVRRP 329
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 481-685 1.17e-14

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 75.79  E-value: 1.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  481 ISQDRRYLRLTVIPRDAVHAPSIPDWYARLKQEAQQA----GFQRVLLGGAPVGSMEFTQALVGAMPAAIGTVFVAtFLL 556
Cdd:pfam03176  80 VSPDGKAAYVVVTLEGDPGTTEADESVAAVRDAVEQApppeGLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVI-FII 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  557 LAVAFRSLVIPLKSILMNTLTVGAAYGLItLVFQEgfaarlvgapTDVGGIDSSLPILMFAVIFGLSMDYEIFLLSRVQE 636
Cdd:pfam03176 159 LLIVYRSVVAALLPLLTVGLSLGAAQGLV-AILAH----------ILGIGLSTFALNLLVVLLIAVGTDYALFLVSRYRE 227

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 902711437  637 AHLAGLDTPQAVRYALERTAGVIGSAALIMVIVFSAFVVGQVVANKTIG 685
Cdd:pfam03176 228 ELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVG 276
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 544-717 4.75e-11

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 66.53  E-value: 4.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  544 AAIGTVFVatFLLLAVAFRSLVIPLKSILMNTLTVGAAYGLITLVFQEGFAArlvgaptdvgGIDSSLPILMFAVIFGLS 623
Cdd:TIGR00833 750 SIITLAIV--FMILALLLRAPVAPIVLIGSVALSYLWALGLSVLAFQHILGA----------ELHWSVLAGVFVLLVALG 817

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  624 MDYEIFLLSRVQEAHLAGLDTPqaVRYALERTAGVIGSAALIMVIVFSAFVVGQVVANKTIGLGLALAVLLDATLVRLVL 703
Cdd:TIGR00833 818 VDYNMLLVSRIKEESPAGNRTG--IIRALGSTGGVITAAGLVFAGTMAALASAQLTAIAQFGFTVGVGILLDTFIVRSVT 895

                         170
                  ....*....|....
gi 902711437  704 VPAVLVLAGRWNWW 717
Cdd:TIGR00833 896 VPALTLLLGRWIWW 909
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 55-458 3.34e-10

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 63.45  E-value: 3.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437   55 QILTEAFGLPPVDRTVLVSESSLPEHDPRFRQTYNQLMAR-----MQTLEGVLRIHRYDAPSPLQqqSQDGKITATLLDT 129
Cdd:TIGR00833  47 KEMSAAFQEAIRDPKIILVLESNERLGDKDYATYDALIAKlradiMHVISVVDFWGPPEAAEGLR--SDDGKATIIIVNL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  130 RLENGE----AVIEALRRE-ARAAQTPEIRFYVTGATAVTKDFLHLLEADVKRSELMALPLTGLVLLLAFGALVATGLPL 204
Cdd:TIGR00833 125 AGEKGQkeaqEAINAVRRIvEQTNAPDGLTVHVTGPLATIADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  205 L-VGV-VAITTGLACLFFLTLWGEVSSFALSVITMLSLGAGM-GGGGGGGGGGGGGGGGGGGGGGGGGAPQTAGRTVAFS 281
Cdd:TIGR00833 205 VsVGFsVVVAQGIVSLLGIPGLIGVNAQTTVLLTALVIGAGTdYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGS 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  282 GLVVAIAMGAMLVPDLTFIRSMGVGGVMAITLTVLVSITLLPALLALLGervnapRRWAFKPTSSGKASPFWGRWASVVM 361
Cdd:TIGR00833 285 ALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEG------REGLMKPGRKSKIRFIWRRLGTAVV 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  362 QRPWMWSFGVMGLLLALAWPATQMKLGYTGAFGLGPHVESRKGLELIRQLELGGALDAFEVLLDLGEEGFTPQNRARWRA 441
Cdd:TIGR00833 359 RRPWPILVTTLIISGVSLLALPLIRTGYDDEKMIPTDLESVQGYEAADRHFPGNSMDPMVVMIKSDHDVRNPALLADIDR 438

                         410
                  ....*....|....*..
gi 902711437  442 LEQRLSAWPEVRLVVSP 458
Cdd:TIGR00833 439 FEREIKAVPGINMVQET 455
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 517-674 3.42e-07

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 53.85  E-value: 3.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  517 AGFQRVLLGGAPVGSMEFTQALVGAMPAAIGTvFVATFLLLAVAFRSLVIPLkSILMnTLTVGaayglitLVFQEGFAAR 596
Cdd:TIGR03480 247 HGVTVRLTGEVALSDEELATVSEGATVAGLLS-FVLVLVLLWLALRSPRLVF-AVLV-TLIVG-------LILTAAFATL 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  597 LVGaptdvggidsSLPIL--MFAVIF-GLSMDYEIFLLSRVQEAHLAGLDTPQAVRYALERTAGVIGSAALIMVIVFSAF 673
Cdd:TIGR03480 317 AVG----------HLNLIsvAFAVLFiGLGVDFAIQFSLRYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFAF 386


                  .
gi 902711437  674 V 674
Cdd:TIGR03480 387 L 387
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 274-685 6.19e-07

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 52.92  E-value: 6.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  274 AGRTVAFSGLVVAIAMGAMLVPDLTFIRSMGVGGVMAITLTVLVSITLLPALLALL--GERVNAPRRWAFKPTSSGKASP 351
Cdd:TIGR00921 292 TGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIdiGREKVKKEIIAIGGKSSEIEEE 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  352 FWgRWASVVMQRPWmwsfgvmGLLLALAwpATQMKLGYtGAFGLGPHVESRKGL-----ELIR----QLELGGALDAFEV 422
Cdd:TIGR00921 372 LS-KVLSITVRHPV-------PALVAAL--IITGLGLY-GAAGIKPEVNIEKFIpqdlpSLQArkviESHMGGSHDFATI 440

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  423 LLDLGEEgftpQNRARWRALEqRLSawpevRLVVSPFLAGRLEGQGGFAELVGLTNQYISQDRryLRLTVIPRD------ 496
Cdd:TIGR00921 441 LVKADDV----RDPELVRFMD-ELS-----RDIKATGVAARVFGAPSIIDLVKEVEGLPAPER--SALEPIPEDeeggyi 508

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  497 -----AVHAP----------SIPDWYARLKQEAQQAGFQRVLLGGAPVGSMEFTQALVGAMP--AAIGTVFVatFLLLAV 559
Cdd:TIGR00921 509 sggqiKVAVIqvqlkqgepkVQGRKILRDVQHEHPPPGVKVGVTGLPVAFAEMHELVNEGMRrmTIAGAILV--LMILLA 586

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  560 AFRSLVIPLKSILMNTLTVGAAYGLITLVfqegfaarlvgaptdvgGIDSSLP-ILMFAVIFGLSMDYEIFLLSRVQEaH 638
Cdd:TIGR00921 587 VFRNPIKAVFPLIAIGSGILWAIGLMGLR-----------------GIPSFLAmATTISIILGLGMDYSIHLAERYFE-E 648

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 902711437  639 LAGLDTPQAVRYALERTAGVIGSAALIMVIVFSAFVVGQVVANKTIG 685
Cdd:TIGR00921 649 RKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFG 695
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 546-725 8.19e-05

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 46.12  E-value: 8.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  546 IGTVFVATFLLLAVaFRSLViplkSILMNTLTVGaayglITLVFQEGFAARLvgAPTDVGGIDSSLPILMFAVIFGLSMD 625
Cdd:TIGR00833 180 ATTGIIVLIILLLV-YRSPI----TMLVPLVSVG-----FSVVVAQGIVSLL--GIPGLIGVNAQTTVLLTALVIGAGTD 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  626 YEIFLLSRVQEAHLAGLDTPQAVRYALERTAGVIGSAALIMVIVFSAFVVGQVVANKTIGlGLALAVLLDATLVRLVLVP 705
Cdd:TIGR00833 248 YAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLG-VSCAVGVLVALLNAVTLTP 326

                         170       180
                  ....*....|....*....|
gi 902711437  706 AVLVLAGRWNWWLPEPLQRV 725
Cdd:TIGR00833 327 ALLTLEGREGLMKPGRKSKI 346
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 522-685 2.02e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 44.83  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  522 VLLGGAPVGSMEFTQALVGAMPAAIGTVFVATFLLLAVAFRS---LVIPLKSILMN-TLTVGAAYglitlvfqegfaarL 597
Cdd:TIGR00921 175 LDVTGSPAINYDIEREFGKDMGTTMAISGILVVLVLLLDFKRwwrPLLPLVIILFGvAWVLGIMG--------------W 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  598 VGAPTDVggidssLPILMFAVIFGLSMDYEIFLLSRVQEAHLAGLDTPQAVRYALERTAGVIGSAALIMVIVFSAFVVGQ 677
Cdd:TIGR00921 241 LGIPLYA------TTLLAVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSE 314


                  ....*...
gi 902711437  678 VVANKTIG 685
Cdd:TIGR00921 315 FPMVSEFG 322
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 5-174 1.21e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 42.06  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437   5 LARLVARYPVQIVLVWLLL-VLLAIPAARLAPqNLAANASAVKNSEAQKVLQILTEAFGLPPVDRTVLVSESSLPEhDPR 83
Cdd:COG2409  352 LARAVVRRPVPVLVAAVAVlLALALPALGLRL-GLPDADSLPADSPSRQGYDALAEHFPPGSNGPLTVVVESDDDL-DPA 429

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902711437  84 FRQTYNQLMARMQTLEGVLRihrydAPSPLQQQSQDGKitATLLDTRLE---NGEAVIEALR--REARAAQTPEIRFYVT 158
Cdd:COG2409  430 DLAALDALAAALAAVPGVAS-----VQPPTRPEGTDGD--AARLQVVPDgdpDSPEAIDLVDrlRDAAAPALEGAEVLVG 502

                        170
                 ....*....|....*.
gi 902711437 159 GATAVTKDFLHLLEAD 174
Cdd:COG2409  503 GTTAVNIDISDALADD 518
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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