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Conserved domains on  [gi|898467850|ref|WP_049592198|]
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MULTISPECIES: LysR substrate-binding domain-containing protein [Enterobacteriaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11074 super family cl32638
putative DNA-binding transcriptional regulator; Provisional
 1-291 1.68e-80

putative DNA-binding transcriptional regulator; Provisional


The actual alignment was detected with superfamily member PRK11074:

Pssm-ID: 182948 [Multi-domain]  Cd Length: 300  Bit Score: 245.62  E-value: 1.68e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   1 MFiSDEVLRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDSL 80
Cdd:PRK11074   1 MW-SEYSLEVVDAVARTGSFSAAAQELHRVPSAVSYTVRQLEEWLAVPLFERRHRDVELTPAGEWFVKEARSVIKKMQET 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  81 CRNTTLIHTGVEQELTVAFNNIVPKNIISEFISEFEKTFDFTQLTVNTEVYNGCWDAIYHNRADVVVGAPHSVPSSDGII 160
Cdd:PRK11074  80 RRQCQQVANGWRGQLSIAVDNIVRPDRTRQLIVDFYRHFDDVELIIRQEVFNGVWDALADGRVDIAIGATRAIPVGGRFA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850 161 SEHVGYMDWDFVVGPQHSLATHIHPLENRELRQYTAVCIRDTATNFIPLYAWHLEGQKAVFVPDLEIAISLIKSNTAIGY 240
Cdd:PRK11074 160 FRDMGMLSWACVVSSDHPLASMDGPLSDDELRPYPSLCLEDTSRTLPKRITWLLDNQRRLVVPDWESAINCLSAGLCVGM 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 898467850 241 LPHHLARPLLNNGRLIKKSMLEHKHATQLFVAAKTDGLGEAGRWCLEY----------WLR 291
Cdd:PRK11074 240 VPTHFAKPLINSGKLVELTLENPFPDSPCCLTWQQNDMSPALAWLLDYlgdsetlnkeWLR 300
 
Name Accession Description Interval E-value
PRK11074 PRK11074
putative DNA-binding transcriptional regulator; Provisional
 1-291 1.68e-80

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 182948 [Multi-domain]  Cd Length: 300  Bit Score: 245.62  E-value: 1.68e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   1 MFiSDEVLRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDSL 80
Cdd:PRK11074   1 MW-SEYSLEVVDAVARTGSFSAAAQELHRVPSAVSYTVRQLEEWLAVPLFERRHRDVELTPAGEWFVKEARSVIKKMQET 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  81 CRNTTLIHTGVEQELTVAFNNIVPKNIISEFISEFEKTFDFTQLTVNTEVYNGCWDAIYHNRADVVVGAPHSVPSSDGII 160
Cdd:PRK11074  80 RRQCQQVANGWRGQLSIAVDNIVRPDRTRQLIVDFYRHFDDVELIIRQEVFNGVWDALADGRVDIAIGATRAIPVGGRFA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850 161 SEHVGYMDWDFVVGPQHSLATHIHPLENRELRQYTAVCIRDTATNFIPLYAWHLEGQKAVFVPDLEIAISLIKSNTAIGY 240
Cdd:PRK11074 160 FRDMGMLSWACVVSSDHPLASMDGPLSDDELRPYPSLCLEDTSRTLPKRITWLLDNQRRLVVPDWESAINCLSAGLCVGM 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 898467850 241 LPHHLARPLLNNGRLIKKSMLEHKHATQLFVAAKTDGLGEAGRWCLEY----------WLR 291
Cdd:PRK11074 240 VPTHFAKPLINSGKLVELTLENPFPDSPCCLTWQQNDMSPALAWLLDYlgdsetlnkeWLR 300
PBP2_HupR cd08431
The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which ...
 94-288 2.86e-44

The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; HupR, a member of the LysR family, activates hupA transcription under low-iron conditions in the presence of hemin. The expression of many iron-uptake genes, such as hupA, is regulated at the transcriptional level by iron and an iron-binding repressor protein called Fur (ferric uptake regulation). Under iron-abundant conditions with heme, the active Fur repressor protein represses transcription of the iron-uptake gene hupA, and prevents transcriptional activation via HupR. Under low-iron conditions with heme, the Fur repressor is inactive and transcription of the hupA is allowed. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.


Pssm-ID: 176122 [Multi-domain]  Cd Length: 195  Bit Score: 149.34  E-value: 2.86e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  94 ELTVAFNNIVPKNIISEFISEFEKTFDFTQLTVNTEVYNGCWDAIYHNRADVVVGAPHSVPSSDgIISEHVGYMDWDFVV 173
Cdd:cd08431    1 ELRIAIDTVLPLQPLYPLIAEFYQLNKATRIRLSEEVLGGTWDALASGRADLVIGATGELPPGG-VKTRPLGEVEFVFAV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850 174 GPQHSLATHIHPLENRELRQYTAVCIRDTATNFIPLYAWHLEGQKAVFVPDLEIAISLIKSNTAIGYLPHHLARPLLNNG 253
Cdd:cd08431   80 APNHPLAKLDGPLDASAIKQYPAIVVADTSRNLPPRSSGLLEGQDRIRVPTMQAKIDAQVLGLGVGYLPRHLAKPELASG 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 898467850 254 RLIKKSMLEHKHATQLFVAAKTDGLGEAGRWCLEY 288
Cdd:cd08431  160 ELVEKALEDPRPPQELFLAWRKDQRGKALAWFVQR 194
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
8-291 2.61e-39

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 138.46  E-value: 2.61e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   8 LRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDSLCRNTTLI 87
Cdd:COG0583    6 LRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRILAELEEAEAELRAL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  88 HTGVEQELTVAFNNIVPKNIISEFISEFEKTFDFTQLTVNTEVYNGCWDAIYHNRADVVVGAPHsvPSSDGIISEHVGYM 167
Cdd:COG0583   86 RGGPRGTLRIGAPPSLARYLLPPLLARFRARHPGVRLELREGNSDRLVDALLEGELDLAIRLGP--PPDPGLVARPLGEE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850 168 DWDFVVGPQHSLAthihplenrelrqytavcirdtatnfiplyawhlegQKAVFVPDLEIAISLIKSNTAIGYLPHHLAR 247
Cdd:COG0583  164 RLVLVASPDHPLA------------------------------------RRAPLVNSLEALLAAVAAGLGIALLPRFLAA 207

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 898467850 248 PLLNNGRLIKKSMLEHKHATQLFVAAKTDG-LGEAGRWCLEyWLR 291
Cdd:COG0583  208 DELAAGRLVALPLPDPPPPRPLYLVWRRRRhLSPAVRAFLD-FLR 251
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
8-64 7.09e-18

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 75.88  E-value: 7.09e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 898467850    8 LRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGE 64
Cdd:pfam00126   4 LRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRGVRLTEAGE 60
 
Name Accession Description Interval E-value
PRK11074 PRK11074
putative DNA-binding transcriptional regulator; Provisional
 1-291 1.68e-80

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 182948 [Multi-domain]  Cd Length: 300  Bit Score: 245.62  E-value: 1.68e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   1 MFiSDEVLRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDSL 80
Cdd:PRK11074   1 MW-SEYSLEVVDAVARTGSFSAAAQELHRVPSAVSYTVRQLEEWLAVPLFERRHRDVELTPAGEWFVKEARSVIKKMQET 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  81 CRNTTLIHTGVEQELTVAFNNIVPKNIISEFISEFEKTFDFTQLTVNTEVYNGCWDAIYHNRADVVVGAPHSVPSSDGII 160
Cdd:PRK11074  80 RRQCQQVANGWRGQLSIAVDNIVRPDRTRQLIVDFYRHFDDVELIIRQEVFNGVWDALADGRVDIAIGATRAIPVGGRFA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850 161 SEHVGYMDWDFVVGPQHSLATHIHPLENRELRQYTAVCIRDTATNFIPLYAWHLEGQKAVFVPDLEIAISLIKSNTAIGY 240
Cdd:PRK11074 160 FRDMGMLSWACVVSSDHPLASMDGPLSDDELRPYPSLCLEDTSRTLPKRITWLLDNQRRLVVPDWESAINCLSAGLCVGM 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 898467850 241 LPHHLARPLLNNGRLIKKSMLEHKHATQLFVAAKTDGLGEAGRWCLEY----------WLR 291
Cdd:PRK11074 240 VPTHFAKPLINSGKLVELTLENPFPDSPCCLTWQQNDMSPALAWLLDYlgdsetlnkeWLR 300
PRK10094 PRK10094
HTH-type transcriptional activator AllS;
6-282 9.67e-63

HTH-type transcriptional activator AllS;


Pssm-ID: 182237 [Multi-domain]  Cd Length: 308  Bit Score: 200.42  E-value: 9.67e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   6 EVLRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDSLCRNTT 85
Cdd:PRK10094   5 ETLRTFIAVAETGSFSKAAERLCKTTATISYRIKLLEENTGVALFFRTTRSVTLTAAGEHLLSQARDWLSWLESMPSELQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  86 LIHTGVEQELTVAFNNIV-PKNIISEFISEFEKTFDFTQLTVNTEVYNGCWDAIYHNRADVVVGAPHSVPSSDGIISEHV 164
Cdd:PRK10094  85 QVNDGVERQVNIVINNLLyNPQAVAQLLAWLNERYPFTQFHISRQIYMGVWDSLLYEGFSLAIGVTGTEALANTFSLDPL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850 165 GYMDWDFVVGPQHSLATHIHPLENRELRQYTAVCIRDTATNFIPLYAWHLEGQKAVFVPDLEIAISLIKSNTAIGYLPHH 244
Cdd:PRK10094 165 GSVQWRFVMAADHPLANVEEPLTEAQLRRFPAVNIEDSARTLTKRVAWRLPGQKEIIVPDMETKIAAHLAGVGIGFLPKS 244

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 898467850 245 LARPLLNNGRLIKKSMLEHKHATQLFVAAKTDGLGEAG 282
Cdd:PRK10094 245 LCQSMIDNQQLVSRVIPTMRPPSPLSLAWRKFGSGKAV 282
PBP2_HupR cd08431
The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which ...
 94-288 2.86e-44

The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; HupR, a member of the LysR family, activates hupA transcription under low-iron conditions in the presence of hemin. The expression of many iron-uptake genes, such as hupA, is regulated at the transcriptional level by iron and an iron-binding repressor protein called Fur (ferric uptake regulation). Under iron-abundant conditions with heme, the active Fur repressor protein represses transcription of the iron-uptake gene hupA, and prevents transcriptional activation via HupR. Under low-iron conditions with heme, the Fur repressor is inactive and transcription of the hupA is allowed. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.


Pssm-ID: 176122 [Multi-domain]  Cd Length: 195  Bit Score: 149.34  E-value: 2.86e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  94 ELTVAFNNIVPKNIISEFISEFEKTFDFTQLTVNTEVYNGCWDAIYHNRADVVVGAPHSVPSSDgIISEHVGYMDWDFVV 173
Cdd:cd08431    1 ELRIAIDTVLPLQPLYPLIAEFYQLNKATRIRLSEEVLGGTWDALASGRADLVIGATGELPPGG-VKTRPLGEVEFVFAV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850 174 GPQHSLATHIHPLENRELRQYTAVCIRDTATNFIPLYAWHLEGQKAVFVPDLEIAISLIKSNTAIGYLPHHLARPLLNNG 253
Cdd:cd08431   80 APNHPLAKLDGPLDASAIKQYPAIVVADTSRNLPPRSSGLLEGQDRIRVPTMQAKIDAQVLGLGVGYLPRHLAKPELASG 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 898467850 254 RLIKKSMLEHKHATQLFVAAKTDGLGEAGRWCLEY 288
Cdd:cd08431  160 ELVEKALEDPRPPQELFLAWRKDQRGKALAWFVQR 194
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
8-291 2.61e-39

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 138.46  E-value: 2.61e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   8 LRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDSLCRNTTLI 87
Cdd:COG0583    6 LRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRILAELEEAEAELRAL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  88 HTGVEQELTVAFNNIVPKNIISEFISEFEKTFDFTQLTVNTEVYNGCWDAIYHNRADVVVGAPHsvPSSDGIISEHVGYM 167
Cdd:COG0583   86 RGGPRGTLRIGAPPSLARYLLPPLLARFRARHPGVRLELREGNSDRLVDALLEGELDLAIRLGP--PPDPGLVARPLGEE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850 168 DWDFVVGPQHSLAthihplenrelrqytavcirdtatnfiplyawhlegQKAVFVPDLEIAISLIKSNTAIGYLPHHLAR 247
Cdd:COG0583  164 RLVLVASPDHPLA------------------------------------RRAPLVNSLEALLAAVAAGLGIALLPRFLAA 207

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 898467850 248 PLLNNGRLIKKSMLEHKHATQLFVAAKTDG-LGEAGRWCLEyWLR 291
Cdd:COG0583  208 DELAAGRLVALPLPDPPPPRPLYLVWRRRRhLSPAVRAFLD-FLR 251
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
8-64 7.09e-18

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 75.88  E-value: 7.09e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 898467850    8 LRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGE 64
Cdd:pfam00126   4 LRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRGVRLTEAGE 60
LysR_substrate pfam03466
LysR substrate binding domain; The structure of this domain is known and is similar to the ...
 94-288 1.93e-15

LysR substrate binding domain; The structure of this domain is known and is similar to the periplasmic binding proteins. This domain binds a variety of ligands that caries in size and structure, such as amino acids, sugar phosphates, organic acids, metal cations, flavonoids, C6-ring carboxylic acids, H2O2, HOCl, homocysteine, NADPH, ATP, sulphate, muropeptides, acetate, salicylate, citrate, phenol- and quinolone derivatives, acetylserines, fatty acid CoA, shikimate, chorismate, homocysteine, indole-3-acetic acid, Na(I), c-di-GMP, ppGpp and hydrogen peroxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460931 [Multi-domain]  Cd Length: 205  Bit Score: 73.48  E-value: 1.93e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   94 ELTVAFNNIVPKNIISEFISEFEKTFDFTQLTVNTEVYNGCWDAIYHNRADVVVGAPHsvPSSDGIISEHVGYMDWDFVV 173
Cdd:pfam03466   3 RLRIGAPPTLASYLLPPLLARFRERYPDVELELTEGNSEELLDLLLEGELDLAIRRGP--PDDPGLEARPLGEEPLVLVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  174 GPQHSLATHiHPLENRELRQYTAVCIRDTATNFIPLYAW----HLEGQKAVFVPDLEIAISLIKSNTAIGYLPHHLARPL 249
Cdd:pfam03466  81 PPDHPLARG-EPVSLEDLADEPLILLPPGSGLRDLLDRAlraaGLRPRVVLEVNSLEALLQLVAAGLGIALLPRSAVARE 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 898467850  250 LNNGRLIKKSMLEHKHATQLFVAAKTDG-LGEAGRWCLEY 288
Cdd:pfam03466 160 LADGRLVALPLPEPPLPRELYLVWRKGRpLSPAVRAFIEF 199
PRK11242 PRK11242
DNA-binding transcriptional regulator CynR; Provisional
 14-78 5.67e-11

DNA-binding transcriptional regulator CynR; Provisional


Pssm-ID: 183051 [Multi-domain]  Cd Length: 296  Bit Score: 61.90  E-value: 5.67e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 898467850  14 VAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDID 78
Cdd:PRK11242  12 VAEHGNFTRAAEALHVSQPTLSQQIRQLEESLGVQLFDRSGRTVRLTDAGEVYLRYARRALQDLE 76
PRK11139 PRK11139
DNA-binding transcriptional activator GcvA; Provisional
 15-112 1.52e-10

DNA-binding transcriptional activator GcvA; Provisional


Pssm-ID: 182990 [Multi-domain]  Cd Length: 297  Bit Score: 60.63  E-value: 1.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  15 AHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILndiDSLCRNTT-LIHTGVEQ 93
Cdd:PRK11139  18 ARHLSFTRAAEELFVTQAAVSHQIKALEDFLGLKLFRRRNRSLLLTEEGQRYFLDIREIF---DQLAEATRkLRARSAKG 94

                         90       100
                 ....*....|....*....|....*
gi 898467850  94 ELTV------AFNNIVPKniISEFI 112
Cdd:PRK11139  95 ALTVsllpsfAIQWLVPR--LSSFN 117
PRK10086 PRK10086
DNA-binding transcriptional regulator DsdC;
14-64 2.09e-10

DNA-binding transcriptional regulator DsdC;


Pssm-ID: 182231 [Multi-domain]  Cd Length: 311  Bit Score: 60.40  E-value: 2.09e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 898467850  14 VAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGE 64
Cdd:PRK10086  25 AARHQSFALAADELSLTPSAVSHRINQLEEELGIKLFVRSHRKVELTEEGK 75
rbcR CHL00180
LysR transcriptional regulator; Provisional
 8-84 8.51e-09

LysR transcriptional regulator; Provisional


Pssm-ID: 177082 [Multi-domain]  Cd Length: 305  Bit Score: 55.41  E-value: 8.51e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 898467850   8 LRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILndidSLCRNT 84
Cdd:CHL00180  10 LRILKAIATEGSFKKAAESLYISQPAVSLQIKNLEKQLNIPLFDRSKNKASLTEAGELLLRYGNRIL----ALCEET 82
PRK12682 PRK12682
transcriptional regulator CysB-like protein; Reviewed
 8-82 1.16e-08

transcriptional regulator CysB-like protein; Reviewed


Pssm-ID: 183679 [Multi-domain]  Cd Length: 309  Bit Score: 55.38  E-value: 1.16e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 898467850   8 LRIV-HLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNI-GLTPSGEYFIQHSKPILNDIDSLCR 82
Cdd:PRK12682   6 LRFVrEAVRRNLNLTEAAKALHTSQPGVSKAIIELEEELGIEIFIRHGKRLkGLTEPGKAVLDVIERILREVGNIKR 82
PRK09791 PRK09791
LysR family transcriptional regulator;
14-77 2.26e-08

LysR family transcriptional regulator;


Pssm-ID: 182077 [Multi-domain]  Cd Length: 302  Bit Score: 54.38  E-value: 2.26e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 898467850  14 VAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDI 77
Cdd:PRK09791  16 VARQGSIRGASRMLNMSQPALTKSIQELEEGLAAQLFFRRSKGVTLTDAGESFYQHASLILEEL 79
PRK10341 PRK10341
transcriptional regulator TdcA;
14-148 2.37e-08

transcriptional regulator TdcA;


Pssm-ID: 182391 [Multi-domain]  Cd Length: 312  Bit Score: 54.48  E-value: 2.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  14 VAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDSLCRNTTLIHTGVEQ 93
Cdd:PRK10341  18 VIRSGSIGSAAKELGLTQPAVSKIINDIEDYFGVELIVRKNTGVTLTPAGQVLLSRSESITREMKNMVNEINGMSSEAVV 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 898467850  94 ELTVAFNNIVPKNIISEFISEFEKTFDFTQLTVNTEVYNGCWDAIYHNRADVVVG 148
Cdd:PRK10341  98 DVSFGFPSLIGFTFMSDMINKFKEVFPKAQVSMYEAQLSSFLPAIRDGRLDFAIG 152
PRK11716 PRK11716
HTH-type transcriptional activator IlvY;
31-80 3.68e-08

HTH-type transcriptional activator IlvY;


Pssm-ID: 236961 [Multi-domain]  Cd Length: 269  Bit Score: 53.28  E-value: 3.68e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 898467850  31 PSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDSL 80
Cdd:PRK11716   5 PSTLSRQIQRLEEELGQPLFVRDNRSVTLTEAGEELRPFAQQTLLQWQQL 54
PRK12683 PRK12683
transcriptional regulator CysB-like protein; Reviewed
 8-194 5.36e-08

transcriptional regulator CysB-like protein; Reviewed


Pssm-ID: 237172 [Multi-domain]  Cd Length: 309  Bit Score: 53.12  E-value: 5.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   8 LRIVHLVAHYQ-SIATAAEQLNKVPSALSYTIKKLEESLGVELFERKG-RNIGLTPSGEYFIQHSKPILNDIDSLCRNTT 85
Cdd:PRK12683   6 LRIIREAVRQNfNLTEVANALYTSQSGVSKQIKDLEDELGVEIFIRRGkRLTGLTEPGKELLQIVERMLLDAENLRRLAE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  86 LIHTGVEQELTVAFNN-----IVPKnIISEFISEFEKTF---------DFTQLTVNTEvyngcwdaiyhnrADVVVgAPH 151
Cdd:PRK12683  86 QFADRDSGHLTVATTHtqaryALPK-VVRQFKEVFPKVHlalrqgspqEIAEMLLNGE-------------ADIGI-ATE 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 898467850 152 SVPSSDGIISehVGYMDWD--FVVGPQHSLaTHIHPLENRELRQY 194
Cdd:PRK12683 151 ALDREPDLVS--FPYYSWHhvVVVPKGHPL-TGRENLTLEAIAEY 192
PRK09906 PRK09906
DNA-binding transcriptional regulator HcaR; Provisional
 8-115 8.05e-08

DNA-binding transcriptional regulator HcaR; Provisional


Pssm-ID: 182137 [Multi-domain]  Cd Length: 296  Bit Score: 52.46  E-value: 8.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   8 LRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDslcrNTTLI 87
Cdd:PRK09906   6 LRYFVAVAEELNFTKAAEKLHTAQPSLSQQIKDLENCVGVPLLVRDKRKVALTAAGEVFLQDARAILEQAE----KAKLR 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 898467850  88 HTGVEQE---LTVAFNNIVPKNIISEFISEF 115
Cdd:PRK09906  82 ARKIVQEdrqLTIGFVPSAEVNLLPKVLPMF 112
PRK15421 PRK15421
HTH-type transcriptional regulator MetR;
8-262 1.29e-07

HTH-type transcriptional regulator MetR;


Pssm-ID: 185319 [Multi-domain]  Cd Length: 317  Bit Score: 51.94  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   8 LRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDSLCR----- 82
Cdd:PRK15421   7 LKTLQALRNCGSLAAAAATLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTPQGEILLQLANQVLPQISQALQacnep 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  83 NTTLIHTGVE-----QELTVAFNNivpkniisefiseFEKTFDFTQLTVNTEVYNGCWDAIYHNRADVVVGApHSVPSSd 157
Cdd:PRK15421  87 QQTRLRIAIEchsciQWLTPALEN-------------FHKNWPQVEMDFKSGVTFDPQPALQQGELDLVMTS-DILPRS- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850 158 GIiseHVGYMdWDF----VVGPQHSLATHihplenrelrqyTAVCIRDTATNFIPLY--------AWHLEGQKAVFVPDL 225
Cdd:PRK15421 152 GL---HYSPM-FDYevrlVLAPDHPLAAK------------TRITPEDLASETLLIYpvqrsrldVWRHFLQPAGVSPSL 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 898467850 226 E------IAISLIKSNTAIGYLPHHLARPLLNNGRLIKKSMLE 262
Cdd:PRK15421 216 KsvdntlLLIQMVAARMGIAALPHWVVESFERQGLVVTKTLGE 258
PRK13348 PRK13348
HTH-type transcriptional regulator ArgP;
14-69 1.74e-07

HTH-type transcriptional regulator ArgP;


Pssm-ID: 237357 [Multi-domain]  Cd Length: 294  Bit Score: 51.51  E-value: 1.74e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 898467850  14 VAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERkGRNIGLTPSGEYFIQH 69
Cdd:PRK13348  13 VVETGSFERAARRLHVTPSAVSQRIKALEESLGQPLLVR-GRPCRPTPAGQRLLRH 67
PRK15092 PRK15092
DNA-binding transcriptional repressor LrhA; Provisional
 8-97 2.87e-07

DNA-binding transcriptional repressor LrhA; Provisional


Pssm-ID: 237907 [Multi-domain]  Cd Length: 310  Bit Score: 50.80  E-value: 2.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   8 LRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDSLCrnTTLI 87
Cdd:PRK15092  16 LRTFVAVADLNTFAAAAAAVCRTQSAVSQQMQRLEQLVGKELFARHGRNKLLTEHGIQLLGYARKILRFNDEAC--SSLM 93

                         90
                 ....*....|
gi 898467850  88 HTGVEQELTV 97
Cdd:PRK15092  94 YSNLQGVLTI 103
PRK09986 PRK09986
LysR family transcriptional regulator;
3-82 4.61e-07

LysR family transcriptional regulator;


Pssm-ID: 182183 [Multi-domain]  Cd Length: 294  Bit Score: 50.11  E-value: 4.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   3 ISDEVLRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDID-SLC 81
Cdd:PRK09986   7 IDLKLLRYFLAVAEELHFGRAAARLNISQPPLSIHIKELEDQLGTPLFIRHSRSVVLTHAGKILMEESRRLLDNAEqSLA 86


                 .
gi 898467850  82 R 82
Cdd:PRK09986  87 R 87
PRK09801 PRK09801
LysR family transcriptional regulator;
8-141 6.02e-07

LysR family transcriptional regulator;


Pssm-ID: 182085 [Multi-domain]  Cd Length: 310  Bit Score: 50.03  E-value: 6.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   8 LRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDSLCRNTTLI 87
Cdd:PRK09801  11 LQVLVEIVHSGSFSAAAATLGQTPAFVTKRIQILENTLATTLLNRSARGVALTESGQRCYEHALEILTQYQRLVDDVTQI 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 898467850  88 HTGVEQELTVAFNNIVPKNIISEFISEFEKtfDFTQLTVNTEVYNGCWDAIYHN 141
Cdd:PRK09801  91 KTRPEGMIRIGCSFGFGRSHIAPAITELMR--NYPELQVHFELFDRQIDLVQDN 142
PRK03601 PRK03601
HTH-type transcriptional regulator HdfR;
23-75 6.97e-07

HTH-type transcriptional regulator HdfR;


Pssm-ID: 235137 [Multi-domain]  Cd Length: 275  Bit Score: 49.63  E-value: 6.97e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 898467850  23 AAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILN 75
Cdd:PRK03601  21 AAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGERLLPYAETLMN 73
PBP2_LTTR_substrate cd05466
The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the ...
 94-253 1.03e-06

The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; This model and hierarchy represent the the substrate-binding domain of the LysR-type transcriptional regulators that form the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, oxidative stress responses, nodule formation of nitrogen-fixing bacteria, synthesis of virulence factors, toxin production, attachment and secretion, to name a few. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.


Pssm-ID: 176102 [Multi-domain]  Cd Length: 197  Bit Score: 48.37  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  94 ELTVAFNNIVPKNIISEFISEFEKTFDFTQLTVNTEVYNGCWDAIYHNRADVVVGAPHsvPSSDGIISEHVGYMDWDFVV 173
Cdd:cd05466    1 TLRIGASPSIAAYLLPPLLAAFRQRYPGVELSLVEGGSSELLEALLEGELDLAIVALP--VDDPGLESEPLFEEPLVLVV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850 174 GPQHSLATHiHPLENRELRQYTAV-CIRDTATNFIPLYAWHLEG---QKAVFVPDLEIAISLIKSNTAIGYLPHHLARPL 249
Cdd:cd05466   79 PPDHPLAKR-KSVTLADLADEPLIlFERGSGLRRLLDRAFAEAGftpNIALEVDSLEAIKALVAAGLGIALLPESAVEEL 157


                 ....
gi 898467850 250 LNNG 253
Cdd:cd05466  158 ADGG 161
PRK12684 PRK12684
CysB family HTH-type transcriptional regulator;
8-117 1.49e-06

CysB family HTH-type transcriptional regulator;


Pssm-ID: 237173 [Multi-domain]  Cd Length: 313  Bit Score: 48.82  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   8 LRIVHLVAHYQ-SIATAAEQLNKVPSALSYTIKKLEESLGVELFERKG-RNIGLTPSGEYFIQHSKPILNDIDSLCR--- 82
Cdd:PRK12684   6 LRFVREAVRQNfNLTEAAKALYTSQPGVSKAIIELEDELGVEIFTRHGkRLRGLTEPGRIILASVERILQEVENLKRvgk 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 898467850  83 NTTLIHTGveqELTVAFNN-----IVPKnIISEFISEFEK 117
Cdd:PRK12684  86 EFAAQDQG---NLTIATTHtqaryALPA-AIKEFKKRYPK 121
PRK14997 PRK14997
LysR family transcriptional regulator; Provisional
 11-74 1.76e-06

LysR family transcriptional regulator; Provisional


Pssm-ID: 184959 [Multi-domain]  Cd Length: 301  Bit Score: 48.45  E-value: 1.76e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 898467850  11 VHLVAHyQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPIL 74
Cdd:PRK14997  11 VHVVEE-GGFAAAGRALDEPKSKLSRRIAQLEERLGVRLIQRTTRQFNVTEVGQTFYEHCKAML 73
PRK10632 PRK10632
HTH-type transcriptional activator AaeR;
14-101 3.72e-06

HTH-type transcriptional activator AaeR;


Pssm-ID: 182601 [Multi-domain]  Cd Length: 309  Bit Score: 47.45  E-value: 3.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  14 VAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDSlcrnttlihtgVEQ 93
Cdd:PRK10632  13 VVEFGSFTAAARQLQMSVSSISQTVSKLEDELQVKLLNRSTRSIGLTEAGRIYYQGCRRMLHEVQD-----------VHE 81


                 ....*...
gi 898467850  94 ELtVAFNN 101
Cdd:PRK10632  82 QL-YAFNN 88
cysB PRK12681
HTH-type transcriptional regulator CysB;
8-117 5.86e-06

HTH-type transcriptional regulator CysB;


Pssm-ID: 183678 [Multi-domain]  Cd Length: 324  Bit Score: 47.20  E-value: 5.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850   8 LR-IVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNI-GLTPSGEYFIQHSKPILNDIDSLcRNTT 85
Cdd:PRK12681   6 LRyIVEVVNHNLNVSATAEGLYTSQPGISKQVRMLEDELGIQIFARSGKHLtQVTPAGEEIIRIAREILSKVESI-KSVA 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 898467850  86 LIHTGVEQ-ELTVAFNN-----IVPkNIISEFISEFEK 117
Cdd:PRK12681  85 GEHTWPDKgSLYIATTHtqaryALP-PVIKGFIERYPR 121
PRK12680 PRK12680
LysR family transcriptional regulator;
19-80 7.14e-06

LysR family transcriptional regulator;


Pssm-ID: 183677 [Multi-domain]  Cd Length: 327  Bit Score: 46.92  E-value: 7.14e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 898467850  19 SIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNI-GLTPSGEYFIQHSKPILNDIDSL 80
Cdd:PRK12680  18 NITLAAARVHATQPGLSKQLKQLEDELGFLLFVRKGRSLeSVTPAGVEVIERARAVLSEANNI 80
nhaR PRK11062
transcriptional activator NhaR; Provisional
 19-64 7.39e-05

transcriptional activator NhaR; Provisional


Pssm-ID: 182938 [Multi-domain]  Cd Length: 296  Bit Score: 43.46  E-value: 7.39e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 898467850  19 SIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGE 64
Cdd:PRK11062  20 SVVGAAEALFLTPQTITGQIKALEERLQGKLFKRKGRGLEPTELGE 65
cbl PRK12679
HTH-type transcriptional regulator Cbl;
32-127 2.38e-04

HTH-type transcriptional regulator Cbl;


Pssm-ID: 183676 [Multi-domain]  Cd Length: 316  Bit Score: 42.10  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 898467850  32 SALSYTIKKLEESLGVELFERKG-RNIGLTPSGEYFIQHSKPILNDIDSLCRNTTLIHTGVEQELTVAFNNIVPKNIISE 110
Cdd:PRK12679  31 SGVSRHIRELEDELGIEIFIRRGkRLLGMTEPGKALLVIAERILNEASNVRRLADLFTNDTSGVLTIATTHTQARYSLPE 110

                         90
                 ....*....|....*..
gi 898467850 111 FISEFEKTFDFTQLTVN 127
Cdd:PRK12679 111 VIKAFRELFPEVRLELI 127
PRK11151 PRK11151
DNA-binding transcriptional regulator OxyR; Provisional
 15-80 1.10e-03

DNA-binding transcriptional regulator OxyR; Provisional


Pssm-ID: 182999 [Multi-domain]  Cd Length: 305  Bit Score: 40.01  E-value: 1.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 898467850  15 AHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRNIGLTPSGEYFIQHSKPILNDIDSL 80
Cdd:PRK11151  13 AEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGLLLVDQARTVLREVKVL 78
PRK11482 PRK11482
DNA-binding transcriptional regulator;
7-78 2.66e-03

DNA-binding transcriptional regulator;


Pssm-ID: 183159 [Multi-domain]  Cd Length: 317  Bit Score: 38.94  E-value: 2.66e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 898467850   7 VLRIVHLVAHYQSIATAAEQLNKVPSALSYTIKKLEESLGVELFERKGRniGLTPSG------EYFIQHSKPILNDID 78
Cdd:PRK11482  33 LLTIFEAVYVHKGIVNAAKILNLTPSAISQSIQKLRVIFPDPLFIRKGQ--GVTPTAyathlhEYISQGLESILGALD 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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