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Conserved domains on  [gi|896139397|ref|WP_049159304|]
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MULTISPECIES: Txe/YoeB family addiction module toxin [Micrococcales]

Protein Classification

type II toxin-antitoxin system YoeB family toxin( domain architecture ID 10008294)

type II toxin-antitoxin system YoeB family toxin similar to Escherichia coli YoeB, which functions as an mRNA interferase and an inhibitor of translation initiation, and is the toxin component of the YoeB-YefM TA module

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4115 COG4115
Toxin component of the Txe-Axe toxin-antitoxin module, Txe/YoeB family [Defense mechanisms];
1-84 4.72e-50

Toxin component of the Txe-Axe toxin-antitoxin module, Txe/YoeB family [Defense mechanisms];


:

Pssm-ID: 443291  Cd Length: 84  Bit Score: 151.81  E-value: 4.72e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896139397  1 MRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFEGIGKPEQLKYGAAGAWSRRITEEHRLVYLVDGEDLIILQA 80
Cdd:COG4115   1 MKLVFTPQAWEDYLYWQKTDKKLLKRINELIKDIKRNPFEGIGKPEPLKGDLSGYWSRRINDEHRLVYRVDDDTIKILQC 80


                ....
gi 896139397 81 RYHY 84
Cdd:COG4115  81 RYHY 84
 
Name Accession Description Interval E-value
COG4115 COG4115
Toxin component of the Txe-Axe toxin-antitoxin module, Txe/YoeB family [Defense mechanisms];
1-84 4.72e-50

Toxin component of the Txe-Axe toxin-antitoxin module, Txe/YoeB family [Defense mechanisms];


Pssm-ID: 443291  Cd Length: 84  Bit Score: 151.81  E-value: 4.72e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896139397  1 MRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFEGIGKPEQLKYGAAGAWSRRITEEHRLVYLVDGEDLIILQA 80
Cdd:COG4115   1 MKLVFTPQAWEDYLYWQKTDKKLLKRINELIKDIKRNPFEGIGKPEPLKGDLSGYWSRRINDEHRLVYRVDDDTIKILQC 80


                ....
gi 896139397 81 RYHY 84
Cdd:COG4115  81 RYHY 84
YoeB_toxin pfam06769
YoeB-like toxin of bacterial type II toxin-antitoxin system; YoeB_toxin is a family of ...
 5-84 1.80e-43

YoeB-like toxin of bacterial type II toxin-antitoxin system; YoeB_toxin is a family of bacterial toxins that forms one component of the type II toxin-antitoxin system in E. coli whose antitoxin is represented by YefM, found in pfam02604. The plasmid encoded Axe-Txe proteins in Enterococcus faecium act as an antitoxin-toxin pair. When the plasmid is lost, the antitoxin is degraded relatively quickly by host enzymes. This allows the toxin to interact with its intracellular target, thus killing the cell or impeding cell growth. These toxins are highly potent protein synthesis inhibitors, specifically blocking the initiation of translation. In the case of YoeB, it binds to the 50 S ribosomal subunit in 70 S ribosomes and interacts with the A site leading to mRNA cleavage at this site. As a result, the 3'-end portion of the mRNA is released from ribosomes, and translation initiation is effectively inhibited.


Pssm-ID: 284238  Cd Length: 80  Bit Score: 135.16  E-value: 1.80e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896139397   5 WDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFEGIGKPEQLKYGAAGAWSRRITEEHRLVYLVDGEDLIILQARYHY 84
Cdd:pfam06769  1 FTPEAWEDYLYWQETDKKILKRINRLIKDIKRDPFEGIGKPEPLKGDLSGYWSRRITDEHRLVYAVDDDELTILSCRYHY 80
toxin_Txe_YoeB TIGR02116
toxin-antitoxin system, toxin component, Txe/YoeB family; The Axe-Txe pair in Enterococcus ...
 5-84 3.93e-36

toxin-antitoxin system, toxin component, Txe/YoeB family; The Axe-Txe pair in Enterococcus faecium and the homologous YefM-YoeB pair in Escherichia coli have been shown to act as an antitoxin-toxin pair. This model describes the toxin component. Nearly every example found is next to an identifiable antitoxin, as indicated by match to models TIGR01552 and/or pfam02604. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 131171  Cd Length: 80  Bit Score: 116.69  E-value: 3.93e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896139397   5 WDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFEGIGKPEQLKYGAAGAWSRRITEEHRLVYLVDGEDLIILQARYHY 84
Cdd:TIGR02116  1 FTPEAWEDYLKWQEADKKLKKKINELIKDVRRDPFKGKGKPEPLKGDLSGYWSRRITDEHRLVYRVLDDEVLILAARYHY 80
 
Name Accession Description Interval E-value
COG4115 COG4115
Toxin component of the Txe-Axe toxin-antitoxin module, Txe/YoeB family [Defense mechanisms];
1-84 4.72e-50

Toxin component of the Txe-Axe toxin-antitoxin module, Txe/YoeB family [Defense mechanisms];


Pssm-ID: 443291  Cd Length: 84  Bit Score: 151.81  E-value: 4.72e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896139397  1 MRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFEGIGKPEQLKYGAAGAWSRRITEEHRLVYLVDGEDLIILQA 80
Cdd:COG4115   1 MKLVFTPQAWEDYLYWQKTDKKLLKRINELIKDIKRNPFEGIGKPEPLKGDLSGYWSRRINDEHRLVYRVDDDTIKILQC 80


                ....
gi 896139397 81 RYHY 84
Cdd:COG4115  81 RYHY 84
YoeB_toxin pfam06769
YoeB-like toxin of bacterial type II toxin-antitoxin system; YoeB_toxin is a family of ...
 5-84 1.80e-43

YoeB-like toxin of bacterial type II toxin-antitoxin system; YoeB_toxin is a family of bacterial toxins that forms one component of the type II toxin-antitoxin system in E. coli whose antitoxin is represented by YefM, found in pfam02604. The plasmid encoded Axe-Txe proteins in Enterococcus faecium act as an antitoxin-toxin pair. When the plasmid is lost, the antitoxin is degraded relatively quickly by host enzymes. This allows the toxin to interact with its intracellular target, thus killing the cell or impeding cell growth. These toxins are highly potent protein synthesis inhibitors, specifically blocking the initiation of translation. In the case of YoeB, it binds to the 50 S ribosomal subunit in 70 S ribosomes and interacts with the A site leading to mRNA cleavage at this site. As a result, the 3'-end portion of the mRNA is released from ribosomes, and translation initiation is effectively inhibited.


Pssm-ID: 284238  Cd Length: 80  Bit Score: 135.16  E-value: 1.80e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896139397   5 WDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFEGIGKPEQLKYGAAGAWSRRITEEHRLVYLVDGEDLIILQARYHY 84
Cdd:pfam06769  1 FTPEAWEDYLYWQETDKKILKRINRLIKDIKRDPFEGIGKPEPLKGDLSGYWSRRITDEHRLVYAVDDDELTILSCRYHY 80
toxin_Txe_YoeB TIGR02116
toxin-antitoxin system, toxin component, Txe/YoeB family; The Axe-Txe pair in Enterococcus ...
 5-84 3.93e-36

toxin-antitoxin system, toxin component, Txe/YoeB family; The Axe-Txe pair in Enterococcus faecium and the homologous YefM-YoeB pair in Escherichia coli have been shown to act as an antitoxin-toxin pair. This model describes the toxin component. Nearly every example found is next to an identifiable antitoxin, as indicated by match to models TIGR01552 and/or pfam02604. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 131171  Cd Length: 80  Bit Score: 116.69  E-value: 3.93e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896139397   5 WDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFEGIGKPEQLKYGAAGAWSRRITEEHRLVYLVDGEDLIILQARYHY 84
Cdd:TIGR02116  1 FTPEAWEDYLKWQEADKKLKKKINELIKDVRRDPFKGKGKPEPLKGDLSGYWSRRITDEHRLVYRVLDDEVLILAARYHY 80
RelE COG2026
mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense ...
 2-78 1.17e-03

mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441629  Cd Length: 85  Bit Score: 34.40  E-value: 1.17e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 896139397  2 RLVWDRSAWEDythWQTTDRKVLKRINTLIDAALRDPFEGigkPEQLKYGAAGAWSRRITEeHRLVYLVDGEDLIIL 78
Cdd:COG2026   3 KVEFTPRALKD---LKKLDKKVQKRIKKKIEELAENPRPG---GKKLKGSLKGLYRLRVGD-YRIIYEIDDDELVVL 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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