|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
11-411 |
1.16e-82 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 257.88 E-value: 1.16e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 11 WWYIMPIVFITYSLAYLDRANFSFAsAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWG 90
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVA-APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 91 ACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREM 170
Cdd:cd17319 80 LFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 171 FIIEGFPAIIWAFFWWVLVkdkpsqagwltesekaalqaqlekeqqgikavrnyseafrsRNVILLCMQYFTWSIGVYGF 250
Cdd:cd17319 160 FIIEGLLGLLLAVLWWFYL-----------------------------------------RQVWGLALGYFGINYALYGL 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 251 VLWLPSIIRSgSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKL--QNRKLFVWPLLLIAAFAFIGSWAVGanNFWLSY 328
Cdd:cd17319 199 LTWLPTYLKQ-ARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTT--SPVVAV 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 329 TLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLT 408
Cdd:cd17319 276 ILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLV 355
|
...
gi 895908824 409 LIV 411
Cdd:cd17319 356 LLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
20-411 |
1.01e-67 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 220.67 E-value: 1.01e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 20 ITYSLAYLDRANFSFAsAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMV 99
Cdd:TIGR00893 1 LVTVINYLDRANLSFA-APMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 100 SNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAI 179
Cdd:TIGR00893 80 GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 180 IWAFFWWVLVKDKPSQAGWLTESEKAALQAQLEKEQQGIKAVRNYS----EAFRSRNVILLCMQYFTWSIGVYGFVLWLP 255
Cdd:TIGR00893 160 IWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKyqikELLKDRRVWGLALGQFLVNIGLGFFLTWFP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 256 SIIRSGSAnMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNR--KLFVWPLLLIAAFAFIGSWAVGANNFWLSYTLLVI 333
Cdd:TIGR00893 240 TYLVQERG-LSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRgkSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 334 AGAAMYAPY--GPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLTLIV 411
Cdd:TIGR00893 319 VALGFFGLGagAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALSYLLL 398
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-414 |
2.93e-60 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 200.10 E-value: 2.93e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 9 KRWWYIMPIVFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLIL 88
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPP-LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 89 WGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWR 168
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 169 EMFIIEGFPAIIWAFFwwvlvkdkpsqagwltesekaalqaqlekeqqgikavrnyseafrsrNVILLCMQYFTWSIGVY 248
Cdd:COG2271 165 AAFLILGLPGLLLALL-----------------------------------------------RFWLLALAYFLVYFALY 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 249 GFVLWLPSIIRSGsANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKlfVWPLLLIAAFAFIGSWAVG-ANNFWLS 327
Cdd:COG2271 198 GFLTWLPTYLVEV-RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRR--KLVLAIGLLLAALALLLLAlLPSPALA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 328 YTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWL 407
Cdd:COG2271 275 IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
|
....*..
gi 895908824 408 TLIVKPA 414
Cdd:COG2271 355 LLLLRET 361
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-412 |
3.73e-50 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 174.30 E-value: 3.73e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 9 KRWWYIMPIVFITYSLAYLDRANFSFAsAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLIL 88
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVL-APPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 89 WGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWR 168
Cdd:COG2223 80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 169 EMFIIEGFPAIIWAFFWWVLVKDKPSQAgwlTESEKAALQAQLekeqqgikavrnysEAFRSRNVILLCMQYFTWSIGVY 248
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGA---AAAAKASLRDQL--------------EALRDPRFWLLSLLYFGTFGSFI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 249 GFVLWLPSIIRSGsANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGanNFWLSY 328
Cdd:COG2223 223 GFSSWLPPYLVDQ-FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG--SLWLFL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 329 TLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLT 408
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLT 379
|
....
gi 895908824 409 LIVK 412
Cdd:COG2223 380 LLLY 383
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
12-338 |
2.18e-42 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 153.94 E-value: 2.18e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 12 WYIMPIVFITYSLAYLDRANFSFASAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGA 91
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 92 CASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTvlwmSVVSGYLIQAL------ 165
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLG----SIFGGLLAYGVfkilgv 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 166 ----GWREMFIIEGFPAIIWAFFWWVLVKDKPSQAGWLTESEKAALQAQLEKEQQG-------IKAVRnysEAFRSRNVI 234
Cdd:cd17327 160 gglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGkgdqkfkWKQIK---EAFKDPRTW 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 235 LLCMQYFTWSIGVYGFVLWLPSIIRSGSANmgMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFV--WPLLLIAAFA 312
Cdd:cd17327 237 LLFLFFFCSQITNNGISNFLPLILKSLGFY--SLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAifACVLALVGSI 314
|
330 340
....*....|....*....|....*.
gi 895908824 313 FIGSWAVGANNFWLSYTLLVIAGAAM 338
Cdd:cd17327 315 ILLAAPNPPGAYFAAYILGGGSYAGF 340
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-377 |
3.68e-36 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 135.62 E-value: 3.68e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 18 VFITYSLAYLDRANFSFASAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTG 97
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 98 MVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFP 177
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 178 AIIWAFFWWVLVKDKPSqagwltesekaalQAQLEKEQQGIKAVRNYSEAFRSRNVILLCMqYFTWSIGVYGFVLWLPSI 257
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES-------------KRPKPAEEARLSLIVAWKALLRDPVLWLLLA-LLLFGFAFFGLLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 258 IrsGSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANNFWLSYTLLVIAGAA 337
Cdd:pfam07690 227 Q--EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFG 304
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 895908824 338 MYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGS 377
Cdd:pfam07690 305 FGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
19-383 |
1.74e-31 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 123.64 E-value: 1.74e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 19 FITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGM 98
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPY-LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 99 VSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFL--------ILGNPVTVLWMSvvsgyliQALGWREM 170
Cdd:TIGR00881 80 STSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWncshnvggGLLPPLVLFGIA-------ELYSWHWV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 171 FIIEGFPAIIWAFFWWVLVKDKP-----SQAGWLTESEKAALQAQLEKEQQGIKAVRNYseAFRSRNVILLCMQYFTWSI 245
Cdd:TIGR00881 153 FIVPGIIAIIVSLICFLLLRDSPqscglPPAEEMPNEEPDGDAEKKEEELTKKQIFLQY--VLLNKVLWYISLGYVFVYV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 246 GVYGFVLWLPsIIRSGSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAA--FAFIGSWAVGANN 323
Cdd:TIGR00881 231 VRTGILDWSP-LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALiiVSLLVYWLNPAAN 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 324 FWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYL 383
Cdd:TIGR00881 310 PLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYL 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-373 |
7.26e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 115.84 E-value: 7.26e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 5 TNAAKRWWYIMPIVFITYSLAYLDRANFSFAsAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFI 84
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPA-LPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 85 CLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQA 164
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 165 LGWREMFIIEGFPAII-WAFFWWVLVKDKPSQAGwltesekaalqaqlekeqqgiKAVRNYSEAFRSRNVILLCMQYFTW 243
Cdd:COG2814 161 FGWRWVFLVNAVLALLaLLLLLRLLPESRPAARA---------------------RLRGSLRELLRRPRLLLLLLLAFLL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 244 SIGVYGFVLWLPSIIRSGsANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWavgANN 323
Cdd:COG2814 220 GFGFFALFTYLPLYLQEV-LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL---AGS 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 895908824 324 FWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGS 373
Cdd:COG2814 296 LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
42-412 |
5.79e-27 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 110.74 E-value: 5.79e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 42 EDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 122 AMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLVKDKPSQagwlte 201
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPP------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 202 sekaalqaQLEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSgSANMGMVEVGWLSSVPYLAA 281
Cdd:cd17325 178 --------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAE-LGGLSPAQIGLLFGAQGLAS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 282 TIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFigsWAVGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGA 361
Cdd:cd17325 249 ALSQPPAGKLSDRIGRKPLILIGLLLSAVALL---LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTA 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 895908824 362 MALINSMGALGSFFGSWFVGYLNgATGSPAASYIFMGVALFASVWLTLIVK 412
Cdd:cd17325 326 MGLFNTAFSLGMVLGPLLGGFLY-DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-409 |
2.42e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 109.05 E-value: 2.42e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 18 VFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTG 97
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPA-LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 98 MVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQAL--GWREMFIIEG 175
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 176 FPAIIWAFFWWVLVKDKPSQAGWLTESEKAALQaqlekeqqgikaVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLP 255
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSKSV------------LKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 256 SIIRSgSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAvgANNFWLSYTLLVIAG 335
Cdd:cd06174 228 LFLLD-LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLL--APSLLLLLLLLLLLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 895908824 336 AAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLTL 409
Cdd:cd06174 305 FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
47-383 |
5.69e-26 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 108.48 E-value: 5.69e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 47 TKGIssLLGAlFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNI--PMLAAIRFILGVVEAAVMPAML 124
Cdd:cd17318 57 TQGI--ILSS-FFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGgyGALIVLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 125 IYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLVkdkpsqagwltesek 204
Cdd:cd17318 134 ALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV--------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 205 aalqaqlekeqqgikavrnyseafrsRNVILLCMQYFTWSIGVYGFVLWLPSIIRSgSANMGMVEVGWLSSVPYLAATIA 284
Cdd:cd17318 199 --------------------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSD-VLHFNIKSNGFLSSLPYLAMWIC 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 285 MIVVSWASDKLQN---------RKLF-VWPLLLIAAFAFIGSWavGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLP 354
Cdd:cd17318 252 SIVGGYLADWLRSrgilstttvRKLFtSIGFLGPGVFLIALGY--LGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAP 329
|
330 340
....*....|....*....|....*....
gi 895908824 355 rNVAGGAMALINSMGALGSFFGSWFVGYL 383
Cdd:cd17318 330 -NYAGTLMGITNTAATIAGIISPLIVGAI 357
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
40-411 |
3.59e-25 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 106.11 E-value: 3.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 120 MPAMLIYISNWFTKSeRSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLVKDKPSQAGWL 199
Cdd:COG2807 124 NVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAA 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 200 TESEKAAlqaqlekeqqgikavrnysEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRsgSANMGMVEVGWLSSVPYL 279
Cdd:COG2807 203 PAAASLR-------------------SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILR--DAGLSAATAGLLLSLFQL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 280 AATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANNFWLSytlLVIAGAAMYAPYGPFFAIIPEMLPR-NVA 358
Cdd:COG2807 262 AGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLW---AVLLGLGQGGLFPLALTLIGLRARTpAEA 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 895908824 359 GGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLTLIV 411
Cdd:COG2807 339 AALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
16-411 |
1.60e-24 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 104.24 E-value: 1.60e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 16 PIVFITYSLAYLDRanFSFASAAG-INEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACAS 94
Cdd:cd17328 2 AVLFLINLLNYMDR--FTIAGVLPdIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 95 LTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQA-LGWREMFII 173
Cdd:cd17328 80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 174 EGFPAIIWAFFWWVLVKDKPSQAgwltESEKAALQAQLEKEQQGIKAVrnyseaFRSRNVILLCMQYFTWSIGVYGFVLW 253
Cdd:cd17328 160 TGVLGVLLAILLLLFVREPPRGA----AEGGVMAKSTATSFLADLKAL------AKNPSFILSTLGFTAVSFVTGALAFW 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 254 LPSIIRSGSANMGMVEV---GWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPL-----LLIAAFAFIGSWAVGANNFW 325
Cdd:cd17328 230 APTFFLRAFGVGDLSSAdvgLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLvcavgLLAAAPFLFLALVLALSNLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 326 LSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMG-ALGSFFGSWFVGYLNGATGSPAASYIFMGVALFAS 404
Cdd:cd17328 310 LAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLShLLGDAGSPYLIGLISDLLRQNKDSPLAEAASLQYA 389
|
....*..
gi 895908824 405 VWLTLIV 411
Cdd:cd17328 390 LLLCSFV 396
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
10-383 |
3.83e-23 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 100.51 E-value: 3.83e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 10 RWWYIMPIVFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILW 89
Cdd:TIGR00895 14 YQWRAIILSFLIMLMDGYDLAAMGFAAPA-ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 90 GACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWRE 169
Cdd:TIGR00895 93 SVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 170 MFIIEG-FPAIIWAFFWWVL-------VKDKPSQAGWLTESEKAALQAQLEKEQQGIKAVRNYSEAF--------RSRNV 233
Cdd:TIGR00895 173 LFYVGGiAPLLLLLLLMRFLpesidflVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVfkalfqgkTARIT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 234 ILLCMQYFTWSIGVYGFVLWLPSIIRSGSANMGMVeVGWLSSVpYLAATIAMIVVSWASDKLQNRKLFVWPlLLIAAFAF 313
Cdd:TIGR00895 253 VLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLA-ATGGALF-NFGGVIGSIIFGWLADRLGPRVTALLL-LLGAVFAV 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 314 IGswAVGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYL 383
Cdd:TIGR00895 330 LV--GSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-405 |
1.27e-22 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 98.06 E-value: 1.27e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 17 IVFITYSLAYLDRANFSFASAA-GINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASL 95
Cdd:cd17316 3 LAGLGWFFDAYDFFLIGFVAPVlAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 96 TGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRA----NTFLILGNPVTVLWMSVVSGYLIQALGWREMF 171
Cdd:cd17316 83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFAlgllQSGWALGALLAALVASLLIPLLSGDWGWRILF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 172 IIEGFPAIIWAFFWwvlvkdkpsqagwltesekaalqaqlekeqqgikavrnyseafrsRNVILLCMQYFTWSIGVYGFV 251
Cdd:cd17316 163 LIGALPALLALLLR---------------------------------------------RRTLLLILLWFFISFGYYGLT 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 252 LWLPSIIRSGSaNMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIgSWAVGANNFWLSYTLL 331
Cdd:cd17316 198 TFLPTYLQTVL-GLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP-LFYLLSGSPTLLLLLL 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 895908824 332 VIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASV 405
Cdd:cd17316 276 FILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
12-407 |
2.71e-22 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 97.34 E-value: 2.71e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 12 WYIMPIVFITYSLAYLDRANFSFASAaGINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGA 91
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKP-PIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 92 CASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMF 171
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 172 IIEGFPAIIWAFFWWVLVKDKPSQagwltesekaalqaqlekeqqgikavrnyseafrsrnVILLCMQYFTWSIGVYGFV 251
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSPPY-------------------------------------VWVLSLAYAFVYIVRYACL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 252 LWLPSIIrSGSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKL--QNRKLFVWPLLLIAAFAFIGSWAVGaNNFWLSYT 329
Cdd:cd17312 204 DWGPLYL-YEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFP-HNKLLSIV 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 895908824 330 LLVIAGAAMYAPYGPFFAIIPEMLPR-NVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWL 407
Cdd:cd17312 282 LLFLIGFFVGGPINLIGGAAAQDIGRkEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLL 360
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
40-404 |
1.71e-21 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 95.31 E-value: 1.71e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMF-IIEGFPAIIWAFFWWVLVKDKPSQAGw 198
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFlAIAVLALLAALLLWRLLPSLPPKKPG- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 199 ltesekaalqaqlekeqqGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSGSANMGMVEVGWLSSVpY 278
Cdd:cd17324 184 ------------------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLF-G 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 279 LAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWavgANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVA 358
Cdd:cd17324 245 VAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLL---GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARG 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 895908824 359 GGA---MALINSMGALGSFFGSWFVGYLnGATGSPAASYIFMGVALFAS 404
Cdd:cd17324 322 LASslyLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLA 369
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
19-389 |
2.73e-21 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 94.54 E-value: 2.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 19 FITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGM 98
Cdd:cd17380 5 FLATCICYADRVNMPIAIVP-MAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 99 V--SNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGF 176
Cdd:cd17380 84 LaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 177 PAIIWAFFWWVLVKdkpsqAGWltesekaalqaqlekeqqgikavrnyseafrsrnVILLCmqYFTWSIGVYGFVLWLPS 256
Cdd:cd17380 164 LGLLWALVWLIYLP-----PVW----------------------------------AIIVA--HFCMNWGFYILLSWLPT 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 257 IIRSG-SANMGMvevGWLSSVPYLAATIAMIVVSWASDKLQN--------RKLF-VWPLLLIAAFAFIGSWavgANNFWL 326
Cdd:cd17380 203 YFHEVlVPLAKG---WVFNVVPWLVMFPSSNVAGWLADHLISrgwtvtsvRKLMqSIGFLGPALFLLLLSH---TDSFSL 276
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 895908824 327 SYTLLVIAGAAMYAPYGPFFAIIPEMLPRNvAGGAMALINSMGALGSFFGSWFVGYLNGATGS 389
Cdd:cd17380 277 ALLCMSVALGLSAFSSSGVLVNHQDIAPNY-AGIVFGISNTAGTIPGIVGVYLTGYILEATGS 338
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
18-411 |
6.28e-21 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 94.23 E-value: 6.28e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 18 VFITYSLAYLDRANFSFASAaGINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTG 97
Cdd:cd17345 8 IFIGYAGYYLVRNNFSLAQP-YLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 98 MV----SNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGN-------PVTVLWMSVVSGyliqALG 166
Cdd:cd17345 87 FVpsatSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHnvggglvGPLAGLGLAIFG----DGW 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 167 WREMFIIEGFPAIIWAFFWWVLVKDKPSQAGWLT------ESEKAALQAQLEKEQQGIKAVRNYseAFRSRNVILLC-MQ 239
Cdd:cd17345 163 WRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPieeykgDYPEEADGEEEEQELSAWEIFVKY--VLKNKLLWYIAiAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 240 YFTWSIGvYGFVLWLPsIIRSGSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQ--NRKLFVWPLLLIAAFAFIGSW 317
Cdd:cd17345 241 VFVYLVR-YGILDWAP-TYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFkgRRAPTGIIFMILVIVALIVYW 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 318 AvgANNFWLSYTLLVIAGAAMyapYGPFFAI---IPEMLPRNVAGGAMALINSMGAL-GSFFGSWFVGYLNGATGSpAAS 393
Cdd:cd17345 319 L--APNVLVDLIALIALGFLI---YGPVMLIglqALELVPKKAAGTAAGLTGLFGYLgGSVLATALIGIIVDHFGW-NGG 392
|
410
....*....|....*...
gi 895908824 394 YIFMGVALFASVWLTLIV 411
Cdd:cd17345 393 FIVLLASCILAIIFLALV 410
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
37-411 |
2.37e-18 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 85.71 E-value: 2.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 37 AAGINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVE 116
Cdd:cd17365 22 APALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 117 AAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFwwvlvkdkpsqa 196
Cdd:cd17365 102 GAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL------------ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 197 gwltesekaalqaqlekeqqgikavrnyseafrSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSGSANMGmvEVGWLSSV 276
Cdd:cd17365 170 ---------------------------------LRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLS--QALTITLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 277 PYLAATIAMIVVSWASDKLQNRKLFVWPLLLiaAFAFIGSWAVGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRN 356
Cdd:cd17365 215 LNIGGVIGSLLLGWLADRFGPKRVLALFFAL--GAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTE 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 895908824 357 VAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLTLIV 411
Cdd:cd17365 293 VRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLL 347
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
35-409 |
2.53e-18 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 86.14 E-value: 2.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 35 ASAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGV 114
Cdd:cd17475 17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 115 VEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLVKDKPS 194
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 195 QAgwlTESEKAAlqaqleKEQQGIKAVRnyseafRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSGsANMGMVEVGWLS 274
Cdd:cd17475 177 AS---AATESAS------TLLRSLKEVL------RNRDVWLIAIAGALLVAPQFALLTFLLLFLHDH-LGLSVVAAGALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 275 SVPYLAATIAMIVVSWASDKL--QNRKLFVWPLLLIAAFAFIG-SWAVGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPE 351
Cdd:cd17475 241 AVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAAIAAAALLVlSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 895908824 352 MLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLTL 409
Cdd:cd17475 321 SAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
42-418 |
2.93e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 86.06 E-value: 2.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 42 EDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMP 121
Cdd:COG0738 36 DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 122 AMLIYISNWFTKSERSRANTFLILgNPVTVLWMSVVSGYLIQA---LGWREMFIIEGFPAIIWAFFWWvlvkdkpsqagw 198
Cdd:COG0738 116 AANPYVAALGPETAASRLNLLHAF-FSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFL------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 199 lteseKAALQAQLEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSGsANMGMVEVGWLSSVPY 278
Cdd:COG0738 183 -----RSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDV-LGLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 279 LAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIgswAVGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNvA 358
Cdd:COG0738 257 GGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL---ALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-T 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 359 GGAMALINSMGALGSFFGSWFVGYLNGATGsPAASYIFMGVALFASVWLTLIVKPANNQQ 418
Cdd:COG0738 333 AAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
58-381 |
5.91e-17 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 82.48 E-value: 5.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 58 FFLGYFFFQIPGAVYAERRSVRKLIFICLilwgACASLTGMVS------NIPMLAAIRFILGVVEAAVMPAMLIYISNWF 131
Cdd:TIGR00894 85 HFYGQIIIQIPVGYLAGKYVFKWSIGIGM----FLSSVISIVIpwaaggGIALVVFCRVIQGLAQGSVSPATHKIIVKWA 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 132 TKSERSRANTFLILGNPVTVLWMSVVSGYLIQA-LGWREMFIIEGFPAIIWAFFWWVLVKDKPSQAGWLTESEKAALQAQ 210
Cdd:TIGR00894 161 PPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSS 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 211 LEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSgSANMGMVEVGWLSSVPYLAATIAMIVVSW 290
Cdd:TIGR00894 241 LQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISW-VLRVSGKENGLLSSLPYLFAWLCSIFAGY 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 291 ASDKLQNRKLFVwpllLIAA---FAFIGSWAVGA---------NNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRnVA 358
Cdd:TIGR00894 320 LADFLKSSKTLS----LTAArkiFNGIGGLGPGIfayalpylsAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPR-FL 394
|
330 340
....*....|....*....|...
gi 895908824 359 GGAMALINSMGALGSFFGSWFVG 381
Cdd:TIGR00894 395 GFIKGITGLPGFIGGLIASTLAG 417
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
73-411 |
2.70e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 76.84 E-value: 2.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 73 AERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRA----NTFLILGNP 148
Cdd:cd17473 59 ADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMlglqSAAMSLGGV 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 149 VTVLwmsvVSGYLIQaLGWREMFIIEGFPAIIWAFFWWVLVKDKPsqagwlTESEKAALQAQLEKeqqgikavrnyseAF 228
Cdd:cd17473 139 VFLL----LGGALAE-IGWRAPFLVYLLALPVLILVLLFLPEPAR------KSKSAASPGAATAA-------------AL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 229 RSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSgSANMGMVEVGWLSSVpylaATIAMIVVSWASDKLQNRKLFVWPLLLI 308
Cdd:cd17473 195 PWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQE-RGGGSAALIGLALAI----ASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 309 AAFAFIGSWAVG-ANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGAT 387
Cdd:cd17473 270 FALMALGFLLLAlASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLT 349
|
330 340
....*....|....*....|....
gi 895908824 388 GSPAASYIFMGVALFASVWLTLIV 411
Cdd:cd17473 350 GGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
19-410 |
4.26e-15 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 76.57 E-value: 4.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 19 FITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGM 98
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPA-LIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 99 VSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQAL----GWREMFIIE 174
Cdd:cd17371 84 AQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLppeiAWRVLFLLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 175 GFPAIIWAFFwwvlvkdkpsqAGWLTESEKAAlQAQLEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVL-W 253
Cdd:cd17371 164 ALPALLVLFI-----------RRFVKEPPQWQ-AARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITtW 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 254 LPSIIRsGSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFvwpllliaAFAFIGSWAVGANNFWL--SYTLL 331
Cdd:cd17371 232 LPSYLT-GERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNF--------ALFALGSAISILLYFFLplSPTLI 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 332 VIAGAA----MYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWL 407
Cdd:cd17371 303 LILGFPlgffASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVL 382
|
...
gi 895908824 408 TLI 410
Cdd:cd17371 383 ALL 385
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
40-408 |
1.43e-14 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 74.60 E-value: 1.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGA-CASLTGMVSNIPMLAAIRFILGVVEAA 118
Cdd:cd17341 25 IRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIpLLALALAVSSYWGLLVLGFLLGFAGAN 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 119 VMPAMlIYISNWFTKSERSRANTFLI----LGNPVTVLWMSVVSGYLIQA---LGWREMFIIEGFPAIIWAFFWWVLVKD 191
Cdd:cd17341 105 FASGQ-PWASFWFPKEKIGGAAGGIAgagnMGVAVSQLLAPLIAGAIVFDggfVGWRNAFFVPGILLAIAAVLVLLFGDD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 192 KPSQAGWLTESEKAALQAqlekeqqgikavrnyseaFRSRNVILLCMQYFtWSIGVY-GFVLWLPSIIRSGSaNMGMVEV 270
Cdd:cd17341 184 LPTGKASALEFLKVQLAV------------------LKNYRTWILSLLYG-VTFGSFvGFSNVLPTYFKTRF-GLPLVTA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 271 GWLSSVPYLAATIAMIVVSWASDKLQNRK--LFVWPLLLIAAFAFIGSWAVGANNFWLSYTLLVIAGAAMYAPYGPFFAI 348
Cdd:cd17341 244 GILAALFPLAGALARPAGGWLSDRFGGRRrlWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRM 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 349 IPEMLPRNVaGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLT 408
Cdd:cd17341 324 VPFIFRREL-GAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLV 382
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
52-410 |
1.95e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 74.19 E-value: 1.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 52 SLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASL-----TGMVSNIPMLAAIRFILGVVEAAVMPAMLIY 126
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVlallaLLGSLSLWLLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 127 ISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLVKDKPSQAGwltesekaa 206
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPG--------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 207 lqaqlEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSGSANMGMVEVGWLSSVPYLAATIAMI 286
Cdd:cd06173 188 -----ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGAL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 287 VVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAvgaNNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALIN 366
Cdd:cd06173 263 LLGRLSKRRRRGRLLLIGALLLGLALLVLGLS---PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYN 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 895908824 367 SMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLTLI 410
Cdd:cd06173 340 ALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-291 |
1.33e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 71.00 E-value: 1.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 2 TSSTNAAKRWWYIMPIVFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKL 81
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 82 IFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYL 161
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 162 IQALGWREMFIIEGFPAIIwAFFWWVLVKDKPSQAGWLTESEKAALQAQLEKEQQGIKAVRNYSEAFRSRNVILLCMQYF 241
Cdd:COG0477 162 VAALGWRWIFLINAPLGLL-ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 895908824 242 TWSIGVYGFVLWLPSIIRSGSANMGMVEVGWLSSVPYLAATIAMIVVSWA 291
Cdd:COG0477 241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLL 290
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
40-405 |
1.16e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.84 E-value: 1.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 120 MPAMLI-YISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLVKDKPsqagw 198
Cdd:cd17355 109 LAAVAFaTVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRP----- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 199 lteSEKAALQAQLEKEQQGIKAVRnysEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRsgSANMGMVEVGWLSSVPY 278
Cdd:cd17355 184 ---ADLALRAYDDASPASPGSTLK---EALRSASFWLLALAFFLCGFAVVGLIVHLVPYLA--DRGISPAAAAVALALIG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 279 LAATIAMIVVSWASDKLQNRKLFVWPLLL----IAAFAFIGSWAVGANNFWLSYTLLVIAGAAMYApygpffAIIPEMLP 354
Cdd:cd17355 256 LFNIVGRLLSGWLGDRYSPRRLLAASYALralgLALLLLLPFPPLALLLFAALFGLGWGATVPLTA------ALAARYFG 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 895908824 355 RNVAGGAMALINSMGALGSFFGSWFVGYLNGATGS-PAASYIFMGVALFASV 405
Cdd:cd17355 330 ARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSyTAAWALAVALGLIAAL 381
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
42-405 |
1.28e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 68.74 E-value: 1.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 42 EDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd17478 24 AKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 122 AMLIYISNwFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLVKDKPSQAGWLTE 201
Cdd:cd17478 104 EGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 202 SEKAALqaqlekeqqgikavrnySEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRsgSANMGMVEVGWLSSVPYLAA 281
Cdd:cd17478 183 KSSARS-----------------TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLV--QRGYSLVFAGLLLSLFLFAG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 282 TIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAvganNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNV---A 358
Cdd:cd17478 244 AIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLT----PGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVglaS 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 895908824 359 GGAMALINSMGALgsffGSWFVGYLNGATGSPAASYIFMGVALFASV 405
Cdd:cd17478 320 GLMMGLSFGLGGI----GAPVLGALADAFGLESVLLILALLPLLGAL 362
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
6-378 |
5.40e-11 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 63.96 E-value: 5.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 6 NAAKRWW--YIMPIVFITYSLAYLDRANFSFASAAGINeDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIF 83
Cdd:PRK11663 14 DARYRYWrrHILITMYLGYALFYFTRKSFNAAMPEMLA-DLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 84 ICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSER----SRANTFLILGNPVTVLwmsvVSG 159
Cdd:PRK11663 93 IGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERggwwAIWNTAHNVGGALIPL----VVG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 160 YLIQALGWREMFIIEGFPAIIWAFFWWVLVKDKPSQAGWLT--ESEKAALQAQLEKEQQGI---KAVRNYseAFRSRNVI 234
Cdd:PRK11663 169 AIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSvgEWRHDALELAQQQEGAGLsrkEILTKY--VLLNPYIW 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 235 LLCMQYFTWSIGVYGFVLW--------LPSIIRSGSANMGMVEVGwlssvpylaATIAMIVVSWASDKL--QNRKlfvwP 304
Cdd:PRK11663 247 LLSFSYVLVYVVRAAINDWgnlymsetLGVDLVTANSAVSMFELG---------GFIGALVAGWGSDKLfnGNRG----P 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 305 LLLIAA---FAFIGS-WAVGANNFWLSYTLLVIAGaamyapygpFFAIIPEML---------PRNVAGGAMALINSMGAL 371
Cdd:PRK11663 314 MNLIFAagiLLSVGSlWLMPFASYVMQAACFFTIG---------FFVFGPQMLigmaaaecsHKEAAGAATGFVGLFAYL 384
|
....*..
gi 895908824 372 GSFFGSW 378
Cdd:PRK11663 385 GAALSGY 391
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
79-388 |
8.12e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.38 E-value: 8.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 79 RKLIFICLILWGACASLT------GMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKS-ERSRANTFLILGNPVTV 151
Cdd:COG2211 81 RPWILIGAIPLALSFVLLftapdlSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYeERTRLSSWRFAFAGLGG 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 152 LWMSVVSGYLI------QALGWREMFIIEGFPAIIWAFFWWVLVKDKPSqagwltesekaalqaqleKEQQGIKAVRNYS 225
Cdd:COG2211 161 LLASVLPPPLVaafggdAALGYRLTALIFAVLGLLAFLLTFFGTKERPV------------------PEEEKVSLKESLK 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 226 EAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSgSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWpL 305
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKY-VLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII-G 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 306 LLIAAFAFIGSWAVGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLP-------RNVAGGAMALINSMGALGSFFGSW 378
Cdd:COG2211 301 LLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGA 380
|
330
....*....|
gi 895908824 379 FVGYLNGATG 388
Cdd:COG2211 381 LAGLLLALFG 390
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
40-411 |
2.50e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 61.82 E-value: 2.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 120 MPAMLIYISNWFTKSERSRAntfliLGNPVTVLWMSVVSGYLIQAL----GWREMFIIEGFPAIIWAFFWWVLVKDKPSQ 195
Cdd:cd17474 105 GPLALTLIGDLFEGGERAKA-----MGLYEAALGLGIAVGPLLGGLlaaiSWRYPFFLLAALIPVAFLAILFLLPEPKEK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 196 AGWLTESEKAALqaqlekeqqgikavrnySEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSgSANMGMVEVGWLSS 275
Cdd:cd17474 180 AKSSSATKLRDL-----------------KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLEL-LYGISPIIIGLLFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 276 VPYLAATIAMIVVSWasdKLQNRKLFVWPLLL-IAAFAFIGSWAVGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLP 354
Cdd:cd17474 242 GWSVLLALGSLFVGR---LLKKRFGARRILVIgLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 895908824 355 RNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAAsYIFMGVALFASVWLTLIV 411
Cdd:cd17474 319 EEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAP-FLVGAAIALAAAVLLALL 374
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
64-412 |
2.74e-10 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 61.47 E-value: 2.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 64 FFQIPGAVYAERRSVRKL-IFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISnWFTKSERSRANTF 142
Cdd:cd17490 46 LLRIPLGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYAS-YFPPDEAAKAMGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 143 LILGNPVTVLWMSVVSGYLIQALGWREMF---IIEGFPAIIWAFFwwvlvkdkpsqagwltesekaaLQAQLEKEQQGIK 219
Cdd:cd17490 125 INLVNNLGQLIAFLIGGLIAEHFGMRAPFllaALAGVLGFILSLF----------------------IKEERREKKPVLT 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 220 AVRNYSEAFRSRNVIL-----LCMQYFTWSiGVYGFVLWLPSIIRSGSAnmgmvEVGWLSSVPYLAATIAMIVVSW-ASD 293
Cdd:cd17490 183 ELKELLSVLKDKKLLFfsllaILQQMITFS-TTFGFTPLIAKQLGASSF-----QLGLLSIIYLLPNALASLLSGTlFYK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 294 KLQNRKLFVWPLLLIAAFAFIgswAVGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGS 373
Cdd:cd17490 257 KLGERNTIIIGFLLLGAYCFL---IPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGM 333
|
330 340 350
....*....|....*....|....*....|....*....
gi 895908824 374 FFGSWFVGYLNGATGSpAASYIFMGVALFASVWLTLIVK 412
Cdd:cd17490 334 FLGPVLVGIISEAFGL-QTGFFVIGVIALLAAILSLAYY 371
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
40-410 |
4.36e-10 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 61.10 E-value: 4.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:PRK12307 44 IKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFfwwvLVKDKPSQAGWL 199
Cdd:PRK12307 124 YACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIY----IRARAPESKEWE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 200 TESEK---AALQAQLEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFvlwLPSIIRSGSANMGMVEVgwLSSV 276
Cdd:PRK12307 200 EAKLSgkgKHSQSAWSVFSLSMKGLFNRAQFPLTLCVFIVLFSIFGANWPIFGL---LPTYLAGEGFDTGVVSN--LMTA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 277 PYLAATIAMIVVSWASDKLQNRKLFVwpLLLIAAFAFI---------GSWAVGANNFWLSYTLLVIAGAAmyapygPFFa 347
Cdd:PRK12307 275 AAFGTVLGNIVWGLCADRIGLKKTFS--IGLLMSFLFIfplfripqdNYLLLGACLFGLMATNVGVGGLV------PKF- 345
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 895908824 348 iIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAAsyIFMGVALFASVWLTLI 410
Cdd:PRK12307 346 -LYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMGLGAA--LTFIVAFWTATILLII 405
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
42-412 |
2.30e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 58.85 E-value: 2.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 42 EDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd06180 27 AELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 122 AMLIYISNWFTKSERSRANTFLILGNPVTVLWMSV-VSGYLIQALGWREMFIIEGFPAIIWAFFWWVLVKDKPSQAGWLT 200
Cdd:cd06180 107 FGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLlVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEAS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 201 ESEKAalqaqlekeqqgikavrnyseAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSGSANMGMVEVGWlsSVPYLA 280
Cdd:cd06180 187 AAESA---------------------PGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLW--SLFGLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 281 ATIAMIVVSWASDKLQNRKLFVWPLLliaafafIGSWAVGANNFWLSYTLLVIaGAAMYApyGPFFAIIPEMLPR----- 355
Cdd:cd06180 244 AVPSCFLWGALSDRWGTRRALAANLL-------VQAVGVLLPLLSPGPAGLVL-SAVLFG--GTFMAITALVMALarela 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 895908824 356 -NVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLTLIVK 412
Cdd:cd06180 314 pPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALLVL 371
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
64-411 |
2.87e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 58.38 E-value: 2.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 64 FFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFI--LGVVEAAVMPAMLIYISnwftksERSRANT 141
Cdd:cd17472 47 IFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALqgSGAISSVVMALLADLTR------EENRTKA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 142 FLILGNPVTVLWM-SVVSGYLIQA-LGWREMFIIEGFPAII-WAFFWWVLVKDKPSQAGwlTESEKAALQAQLekeqqgi 218
Cdd:cd17472 121 MALIGASIGIAFAiSMVLGPLLAAhLGVSGLFLITAILSLVsLLILLFFVPDPPKIVQI--SEKEKKKLKKLL------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 219 kavrnyseafRSRNVILLCMQYFTWSIGVYGFVLWLP---SIIRSGSANMGMVevgwlssvpYLAATIAMIVVSWASDKL 295
Cdd:cd17472 192 ----------KNKRLLRLDFSIFILHFVLMAFFYILPlllTQLGGGKGQLWKV---------YLPAILIGFILMVPFVIY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 296 QNRKLFVWPLLLIA----AFAFIGSWAvGANNFWLSYTLLVI--AGAAMYAPYGPffAIIPEMLPRNVAGGAMALINSMG 369
Cdd:cd17472 253 AEKKGKMKQVFVSSilliAVGFLLLLF-AATSLWLLIIGLIIffIGFNLLEALLP--SLVSKIAPKEYRGTAMGIYNTSQ 329
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 895908824 370 ALGSFFGSWFVGYLNgatGSPAASYIFMGVALFASVWLTLIV 411
Cdd:cd17472 330 FLGSFLGGALGGLLW---GLLGYSSVFLTILILALLWLLVSF 368
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
50-409 |
7.02e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 56.82 E-value: 7.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 50 ISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISN 129
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 130 WFTKSERSRANTFLILGNPVTVLWMSVVsGYLIQAlgWREMFIIEGFPAIIWAFFWWVLvkdkpsqagwltesekaalqa 209
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMLLALL-AYLIRD--WRWLQLAISLPGLLFLLLLWWL--------------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 210 qlekeqqgikavrnyseafrSRNVILLCMQYFTWSIGVYGFVLWLPSI---IRSGSANMGMVEVgwlssvpylaatIAMI 286
Cdd:cd17317 162 --------------------PRRTIIVGLIWFVTSLVYYGLSLNSSNLggnLYLNFFLSGLVEI------------PAYF 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 287 VVSWASDKLqNRKLFVWPLLLIAAFAFIGSWAVGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALIN 366
Cdd:cd17317 210 LALLLLDRL-GRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCS 288
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 895908824 367 SMGALGSFFGSwFVGYLngATGSPAASYIFMGVALFASVWLTL 409
Cdd:cd17317 289 TVARVGAILAP-FIVLL--GKIGPLLPLIIFGVLALLGGLLTL 328
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
42-411 |
8.29e-09 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 56.79 E-value: 8.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 42 EDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPML-AAIRFILGVVEAAVM 120
Cdd:cd17352 31 EEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLyLTYGVLGGLGLGLIY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 121 PAMLIYISNWFTKsERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFwwvlvkdkpsqagwlt 200
Cdd:cd17352 111 SPAIVIVGQYFEK-KRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVC---------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 201 esekAALqaqlekeqqgikavrnySEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSGSANMGmvEVGWLSSVPYLA 280
Cdd:cd17352 174 ----GLL-----------------LRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDES--DAAFLLSIIGIS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 281 ATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVgANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGG 360
Cdd:cd17352 231 DIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPL-ATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSN 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 895908824 361 AMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLTLIV 411
Cdd:cd17352 310 AYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
236-416 |
1.24e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 56.27 E-value: 1.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 236 LCMQYFTWSIGVYGFVLWLPSIIrSGSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIG 315
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLL-AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 316 SWAvgaNNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYI 395
Cdd:pfam07690 80 LFA---SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180
....*....|....*....|.
gi 895908824 396 FMGVALFASVWLTLIVKPANN 416
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPES 177
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
40-410 |
1.77e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 56.04 E-value: 1.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMF-IIEGFPAIIWAFFWWVLVKDKPSQAgw 198
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFvFLALLGLLLLLLVLLFLPETLPEEK-- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 199 ltesEKAALQAQLekeqqgikavRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPsIIRSGSANMGMVEVGWLSSVPY 278
Cdd:cd17320 183 ----RKPLLSSLL----------RAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAP-FIYIEQLGLSPAQFGLLFALNA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 279 LAATIAMIVVSWASDKLQNRKLFVW--PLLLIAAFAFIGSWAVGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRn 356
Cdd:cd17320 248 IALILGSLLNGRLVRRFGPRRLLRLglLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPH- 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 895908824 357 VAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMgVALFASVWLTLI 410
Cdd:cd17320 327 VAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILV-LGLLALLLLILL 379
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
279-405 |
3.27e-08 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 55.23 E-value: 3.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 279 LAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANNFWLS-YTLLVIAGAAMYAPYGPFFAIIPEMLPRNV 357
Cdd:cd17369 275 VVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIvLAAVVVLGVLHGMMYGPQAAFLAELFPTRV 354
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 895908824 358 AGGAMAL-INSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASV 405
Cdd:cd17369 355 RYTGASLgYQLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVISL 403
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
228-412 |
3.49e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.98 E-value: 3.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 228 FRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSGSANMGMVevGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLL 307
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA--GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 308 IAAFAFIGSWAvgaNNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGAT 387
Cdd:COG2814 85 FALGSLLCALA---PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180
....*....|....*....|....*
gi 895908824 388 GSPAASYIFMGVALFASVWLTLIVK 412
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLP 186
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
236-418 |
3.63e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.89 E-value: 3.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 236 LCMQYFTWSIGVYGFVLWLPSIIRSGSAnmGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIG 315
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGA--SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 316 SWAvgaNNFWLSYTLLVIAGAAMyAPYGP-FFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASY 394
Cdd:cd17325 79 AFA---TSYWQLLLARFLQGLAS-AAVWPaAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL 154
|
170 180
....*....|....*....|....
gi 895908824 395 IFMGVALFASVWLTLIVKPANNQQ 418
Cdd:cd17325 155 VCAALALLALVLALLLLPEPRPPP 178
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
47-188 |
3.91e-08 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 55.04 E-value: 3.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 47 TKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILwgacASLTGMVSNIPM------LAAIRFILGVVEAAVM 120
Cdd:cd17382 47 TPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFV----TSTLNMLIPIAArvhygcVIFVRILQGLVEGVTY 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 895908824 121 PAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVL 188
Cdd:cd17382 123 PACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV 190
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
43-411 |
4.57e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.52 E-value: 4.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 43 DLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPA 122
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 123 MLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIE-GFPAIIWAFFWwvLVKDKPSQAGWLTE 201
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAaVLALLALLLVF--LVKDPPPVAAEEAE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 202 SEKAALQaqlekeqqgikavrnyseAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRS-GSANMGMVevgwlssvpYLA 280
Cdd:cd17489 183 AGTRAFR------------------RLVEKKVLPPALILFLASIAYGAISTFLPLYAAErGISNAGLF---------FTV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 281 ATIAMIVVSWASDKLQNR---KLFVWPLLLIAAFAFIGSWAvgANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNV 357
Cdd:cd17489 236 YAIALLLSRPFSGKLSDRkgpKTVIIPGLLLLALGLLLLSF--AGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHR 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 895908824 358 AGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLTLIV 411
Cdd:cd17489 314 RGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
40-411 |
6.77e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 54.15 E-value: 6.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLaairfILGVVEAAV 119
Cdd:cd17353 29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLL-----FLGYGVLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 120 MPAMLIYIS------NWFtKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLVKDKP 193
Cdd:cd17353 104 IGAGIGYITpvstavKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 194 sqAGWLTESEKAALQAQLEKEQQgikavRNYSEAFRSRNVILLCMQYFT-WSIGVYGFVLWlpSIIRSGSANMGMVEVGW 272
Cdd:cd17353 183 --KGWVPPGVDPLANNAENSPRD-----YTPREMLRTPTFWLLWLMFFLnATAGLMLIGQA--KPIGQEFAGLDAGIAAL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 273 LSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAvgANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEM 352
Cdd:cd17353 254 AVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFI--GSVAVLFVLGVALIGFCYGGGFALFPALTADF 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 895908824 353 LPRNVAGGAMALINSMGALGSFFGSwFVGYLNGATGSPAASYIFMGVALFASVWLTLIV 411
Cdd:cd17353 332 FGTKNAGTNYGLLYTAKGVGGLIGP-IIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
53-420 |
8.27e-08 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 54.25 E-value: 8.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 53 LLGALFFLGYFffqIPGAVY---AERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISN 129
Cdd:TIGR00898 131 LTQSCFFVGVL---LGSFVFgylSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 130 WFTKSERSRANTFLILGNPVTVLWMSVVsGYLIQalGWREMFIIEGFPAIIWAFFWWVLvkdkPSQAGWLTES---EKA- 205
Cdd:TIGR00898 208 FLPKKQRAIVGTLIQVFFSLGLVLLPLV-AYFIP--DWRWLQLAVSLPTFLFFLLSWFV----PESPRWLISQgriEEAl 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 206 -----------------ALQAQLEKEQQGIKAVRNYSEAFRSRNV----ILLCMQYFTWSIGVYGFVLWLPSIirSGS-- 262
Cdd:TIGR00898 281 kilqriakingkklpaeVLSLSLEKDLSSSKKQYSFLDLFRTPNLrkttLCLMMLWFTTAFSYYGLVLDLGNL--GGNiy 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 263 ---ANMGMVEVgwlssvpylaatIAMIVVSWASDKLQNRKLFVwPLLLIAAFAFIGSWAVGANNFWLSYTLLVIAGAAMY 339
Cdd:TIGR00898 359 ldlFISGLVEL------------PAKLITLLLIDRLGRRYTMA-ASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGIT 425
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 340 APYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFgSWFVGYLNGAtgSPAASYIFMGVALFASVWLTLIVKPANNQQL 419
Cdd:TIGR00898 426 SAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSII-SPFLVYLGEK--WLFLPLVLFGGLALLAGILTLFLPETKGVPL 502
|
.
gi 895908824 420 P 420
Cdd:TIGR00898 503 P 503
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
79-376 |
1.28e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 53.33 E-value: 1.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 79 RKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVS 158
Cdd:cd17321 61 KRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 159 GYLIQALGWREMFIIEGFPAIIwAFFWwvlvkdkpsqagwltesekaalqaqlekeqqgikavrnySEAFRSRNVILLCM 238
Cdd:cd17321 141 GLLLELFGWRWIFLINVPIGLV-ALLL---------------------------------------ARTFSGAVLAAFLL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 239 qyftwSIGVYGFVLWLPSIIrSGSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWA 318
Cdd:cd17321 181 -----GAALGGLLFLLPLYL-QGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALL 254
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 895908824 319 VGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFG 376
Cdd:cd17321 255 GADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
12-197 |
1.47e-07 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 53.11 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 12 WYIMPIVFITYSLAYLDRANFSFASAAGINEdLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGA 91
Cdd:cd17343 2 LTIFASMFVGYTLYYFNRKSFSFVLPSLMNE-LGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 92 CASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMF 171
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180
....*....|....*....|....*.
gi 895908824 172 IIEGFPAIIWAFFWWVLVKDKPSQAG 197
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVG 186
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
53-189 |
1.64e-07 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 52.86 E-value: 1.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 53 LLGAlFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPM--LAAIRFILGVVEAAVMPAMLIYISNW 130
Cdd:cd17381 70 ILGS-FFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAgyLIAVRALEGLGEGVTFPAMHAMWASW 148
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 895908824 131 FTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLV 189
Cdd:cd17381 149 APPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV 207
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
40-189 |
2.12e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 52.58 E-value: 2.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:cd17323 25 IAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSP 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIegfpAIIWAFFWWVLV 189
Cdd:cd17323 105 LAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWF----LAIISGFCLILI 170
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
73-377 |
3.11e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 52.19 E-value: 3.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 73 AERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVL 152
Cdd:cd17503 55 ADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPA 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 153 WMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLvkdkpsqagwltesekaalqaQLEkeqqgikavrnyseAFRSRN 232
Cdd:cd17503 135 IGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL---------------------DLR--------------LFKDRN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 233 VILLCMQYFTWSIGVYGFVLWLPSIIrSGSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFA 312
Cdd:cd17503 180 FTLGLLLSFLLGLGLFGAMFLLPLYL-QNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGT 258
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 895908824 313 FIGSWAVGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGS 377
Cdd:cd17503 259 LLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGT 323
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-189 |
4.15e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.81 E-value: 4.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 41 NEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVM 120
Cdd:cd17325 227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVF 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 895908824 121 PAMLIYISNWFTKSERSRA----NTFLILGNPVTvlwmSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLV 189
Cdd:cd17325 307 PATLALLADIVPPEGRGTAmglfNTAFSLGMVLG----PLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
14-381 |
5.13e-07 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 51.25 E-value: 5.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 14 IMPIVFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACA 93
Cdd:cd17488 4 ILASMFIGYAVFYLTRKSFNAAMPA-MLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIIN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 94 SLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFII 173
Cdd:cd17488 83 ILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 174 EGFPAIIWAFFWWVLVKDKPsqagwltesekaalqaqlekeqqgikavrnyseafrsRNVILLCMQYFTWSIGVYGFVLW 253
Cdd:cd17488 163 PGIIAILMGIVLCWRLRDRP-------------------------------------PYIWLLAFCYVLVYVVRTAINDW 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 254 lPSIIRSGSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKL--QNRklfvWPLLLIAA----FAFIGSWAVGANNFWLS 327
Cdd:cd17488 206 -GNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLfkGNR----GPMNLIFAlgllVSVGALWLVPVHSYWLL 280
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 895908824 328 YTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVG 381
Cdd:cd17488 281 ATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLA 334
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
51-406 |
1.86e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 49.96 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 51 SSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTG---MVSNIPMLAAIRFILGVVEAAVMPAMLIYI 127
Cdd:pfam00083 48 SGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGaakGKWSVYQLIVGRVLVGIGVGGASVLAPMYI 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 128 SNWFTKSERSRA----NTFLILGNPVTVlWMSVVSGYLIQALGWREMFIIEGFPAI---IWAFFW-----WVLVKDKPSQ 195
Cdd:pfam00083 128 SEIAPKKLRGALgslyQLAITFGILLAY-IFGLGLNKTSNSDGWRIPLGLQLVPALlliIGLLFLpesprWLVEKGRLEE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 196 A------GWLTESEKAALQAQLEKEQQGIKAVRNY-SEAFRSRN--------VILLCMQYFTwsiGVYGFVLWLPSIIRs 260
Cdd:pfam00083 207 ArevlakLRGVPDVDRELDEIKDSLEAGQEAEKASwKELFSTKTrrqrlligVMLQIFQQLT---GINAIFYYSTTIFE- 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 261 gsaNMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLL-LIAAFAFIGSWAVGANNFWLSYTLLVIAGAAMY 339
Cdd:pfam00083 283 ---NLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAgMAICFVILGIVALLGVSKSDWAGIVAIVFIALF 359
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 895908824 340 -APYGP-----FFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVW 406
Cdd:pfam00083 360 iAFFAMgwgpvPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIF 432
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
42-407 |
4.59e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 48.32 E-value: 4.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 42 EDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 122 AMLIYISNWFTKSERSRantflILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLVkdkpsqagwlte 201
Cdd:cd17477 104 VSESWLNALATNENRGR-----VLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLL------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 202 sekAALQAQLEKEQQGIKAVRNYSeafrsRNVILLCMQYFTWSIGVYGFVLWLPsiIRSGSANMGMVEVGWLSSVPYLAA 281
Cdd:cd17477 167 ---LTRRAAPEIEEAESISLRRLL-----RIAPLALLGAFVAGFLEGAFYSLLP--LYGLRLGLSVAQAALLLAAFVLGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 282 TIAMIVVSWASDKLQNRKLFVWpLLLIAAFAFIGSWAVGANNFWLsYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGA 361
Cdd:cd17477 237 LLLQWPLGWLADRFDRRRVLLG-CALLGALAALLLPLVPGLPLAL-LVLLFLWGGAAGPLYTLALALAGDRLPGDELVAA 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 895908824 362 MALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWL 407
Cdd:cd17477 315 NAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
43-411 |
6.65e-06 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 47.96 E-value: 6.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 43 DLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPA 122
Cdd:cd17358 35 SLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 123 MLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLiqalGWREMFIIEG---FPAIIWAFF-----WWVLVKDKPS 194
Cdd:cd17358 115 VPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL----PWRTLALIGAippVVFLILLFFipespRWLAKKGREE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 195 QA----GWL------TESEKAALQAQLEKEQQGIKAVRnYSEAFRSRN----VILLCMQYFTWSIGVYGFVLWLPSIIRS 260
Cdd:cd17358 191 EAekslQFLrgkdadISKEAAEIQEELAELEKEAKESS-FSDLFQRKYlkplVIGLGLMLFQQLSGINAVIFYASSIFDE 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 261 G----SANMGMVEVGwlsSVPYLAATIAMIVVswasDKLQNRklfvwPLLLI-AAFAFIGSWAVGANNF----------- 324
Cdd:cd17358 270 AgsglDPNTATIIIG---VVQVVGTLVATLLV----DRLGRR-----PLLLVsAIGMGIGLLALGLYFYlqehgallssv 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 325 -WLSYTLLVIAGAAMYAPYGP-FFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALF 402
Cdd:cd17358 338 sWLPLVGLVIYIISFSIGLGPlPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGL 417
|
....*....
gi 895908824 403 ASVWLTLIV 411
Cdd:cd17358 418 ALVFVLLFV 426
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
42-188 |
1.41e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 42 EDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd06173 237 EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNV 316
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 895908824 122 AMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVL 188
Cdd:cd06173 317 PLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
265-426 |
1.58e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.79 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 265 MGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANNFWLSYTLLVIAGAAMYAPygp 344
Cdd:COG2807 50 LSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVL--- 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 345 FFAIIPEMLPRNVaGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLTLIVKPANNQQLPIGAR 424
Cdd:COG2807 127 LPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA 205
|
..
gi 895908824 425 HA 426
Cdd:COG2807 206 AS 207
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
68-391 |
2.20e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 46.49 E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 68 PGAVYAER---RSVRKLIFICLI-LWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFL 143
Cdd:PRK11551 65 PGALLGGRladRIGRKRILIVSVaLFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLM 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 144 ILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAffwwvlvkdkPSQAGWLTESEKAALQAQLEKEQQGIKAVRn 223
Cdd:PRK11551 145 YCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLV----------PLLMRWLPESRAFAQAAGAGKQRAPVLRAL- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 224 YSEAfRSRNVILLCMQYFTWSIGVYGFVLWLPSIIrsGSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKL--- 300
Cdd:PRK11551 214 FGEG-RATATLLLWISYFFTLIVLYFLLNWLPSLL--VGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVvll 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 301 -FVWPLLLIAAFAFIGSWAVGANNFWLSYTLLVIAGAAMYAPYGPFFaiipemlPRNVAGGAMALINSMGALGSFFGSWF 379
Cdd:PRK11551 291 iYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFY-------PTQVRGTGVGAAVAVGRLGSMAGPLL 363
|
330
....*....|..
gi 895908824 380 VGYLNGATGSPA 391
Cdd:PRK11551 364 AGQLLALGRSTV 375
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
243-407 |
8.49e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.51 E-value: 8.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 243 WSIGVYGFVLwlPSIIRSGSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVgan 322
Cdd:cd17316 13 YDFFLIGFVA--PVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP--- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 323 NFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAA---SYIFMGV 399
Cdd:cd17316 88 TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGwriLFLIGAL 167
|
....*...
gi 895908824 400 ALFASVWL 407
Cdd:cd17316 168 PALLALLL 175
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
244-411 |
9.61e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 9.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 244 SIGVYGFVLWLPSIIRSgsANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANN 323
Cdd:cd17339 209 SLLFYTLMAWLPTILID--AGLSAATAGWLLSLFQLVGIPASLLVPILATRLKNQRPIVVLLAVLFIIGVLGLLFAPTAL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 324 FWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMAliNSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFA 403
Cdd:cd17339 287 ALLWAVLLGLGGGAAFSLALTLISLRSSDPAEAAALSGMA--QSVGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVL 364
|
....*...
gi 895908824 404 SVWLTLIV 411
Cdd:cd17339 365 QLVAGLGA 372
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
42-190 |
1.02e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.11 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 42 EDLGITK---GISSLLGALFFLGYFFFqipGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAA 118
Cdd:cd17335 226 QDLGGSKtliGLLWTVGVVSEIPFFFF---SSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFAL 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 895908824 119 VMPAMLIYISNWFTKSERSRANTFL-ILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLVK 190
Cdd:cd17335 303 VWAAAVSYASAAAPPGLRATAQGLLqGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
229-410 |
1.09e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 43.65 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 229 RSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSGSANMGMVevGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLI 308
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL--GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 309 AAFAFIGSWAVGANNFWLSYTLLVIAGAAMYAPYgpfFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATG 388
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGA---LALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
|
170 180
....*....|....*....|..
gi 895908824 389 SPAASYIFMGVALFASVWLTLI 410
Cdd:COG0477 167 WRWIFLINAPLGLLALVLRLRL 188
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
50-413 |
1.35e-04 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 44.53 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 50 ISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFIC-----LILWGACASLtgMVSNIPMLAAIRFILGVVEAAVMPAML 124
Cdd:PRK08633 48 LTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVklfevGLTLLIVLAY--YLGWFWLAFAVTFLLGAQSAIYSPAKY 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 125 IYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALG-----------WREMFIIEGFpAIIWAFFWWVLVKDKP 193
Cdd:PRK08633 126 GIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESVNgntpseilgriAPAGLVLLAV-AVLGLIFAYRLPKVPA 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 194 SQAgWLTESEKAALQAQLekeQQGIKAVrnyseafRSRNVILLC---MQYFtWSIGvygfVLWLPSIIRSGSANMGMVEV 270
Cdd:PRK08633 205 AAP-EVFDKKKYLFPKLL---WRNLKLL-------RSDRVLWLAiigLSYF-WFIS----QLAQANFPAYAKEVLGLDNT 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 271 gWLSSVPYLAATIAMIVVSWASDKLQNRK--LFVWPL--LLIAAFAFIGSWavgANNFWLSYTLLVIAG--AAMYAPygP 344
Cdd:PRK08633 269 -FQVQYLLAASAIGIGIGSLLAGRLSGRHieLGLVPLgaLGLALSLFLLPT---APSLASVLVLFFLFGfsAGLFIV--P 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 895908824 345 FFAIIPEMLPRNVAGGAMA---LINSMGALGSFFGSWFVGYLNgatGSPAASYIFMGVALFASVWLTLIVKP 413
Cdd:PRK08633 343 LNALIQFRAPEKELGKVLAannFLQNVGMLLFLALTTLFSGLG---LSPAGLFYLIALVTLIGTLYTLLLLP 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
42-193 |
1.86e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.32 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 42 EDLGITKGISSLLGALFFLGYFFFQIPGAVYAER--RSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:COG2271 209 EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGA 288
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 895908824 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLVKDKP 193
Cdd:COG2271 289 FGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
168-407 |
2.67e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 2.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 168 REMFIIEGFPAIIWAFFWWVLVKDKPSQAGWLTESEKAalqaqlekeqqgikavrnySEAFRSRNVILLCMQYFTWSIGV 247
Cdd:cd17370 156 RTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKT-------------------SLKKLPKAFWLYLLAVALFALGN 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 248 YGFVLwlpSIIRSGSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIgswAVGANNFWLS 327
Cdd:cd17370 217 FSFAF---LILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLG---FALGSSLWLL 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 328 YTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWL 407
Cdd:cd17370 291 LLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
234-377 |
3.89e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 42.61 E-value: 3.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 234 ILLCMQYFTWSIGVYGFVLWLPSIIRS--GSANmgmveVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAF 311
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADlgPSSN-----STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVG 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 895908824 312 AFIGSWAVGANNFWLSYTLLVIAGAAMyapyGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGS 377
Cdd:cd06179 76 SIVAGTAKSVNMLIGGQALIGIGAGTQ----GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGP 137
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
270-420 |
5.58e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.83 E-value: 5.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 270 VGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIA--AFAFIGSWAVGANNFWLSYTLLVIAGAAMYAPYGPFFA 347
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRAllAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 895908824 348 IIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGsPAASYIFMGVALFASVWLTLIVKPANNQQLP 420
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG-PGGAFAINALSFLLSALLLLFIRRPPPAAPG 187
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
52-412 |
5.64e-04 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 41.92 E-value: 5.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 52 SLLGAL---FFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGM-----VSNIPMLAAIRFILGVVEAAVMPAM 123
Cdd:cd17344 62 ELLGALdsaFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLgyywnIHSLWYFVVVQILAGLFQSTGWPSV 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 124 LIYISNWFTKSERSrantfLILGnpvtvLWMSVVS-----GYLIQAL----GWREMFIIegfPAIIWAFF----WWVLVK 190
Cdd:cd17344 142 VACVGNWFGKGKRG-----LIMG-----IWNSHTSvgnilGSLIAGIfvssAWGLSFIV---PGIIIAAMgvlvFLFLVE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 191 DKPsqagwltesekaalqaqlekeqqgikAVRNYSeafrsrnvilLCMqYFTWSIGvYGFVLWLPSIIrSGSANMGMVEV 270
Cdd:cd17344 209 HPP--------------------------GVIEFS----------LCL-FFAKLVS-YTFLYWLPLYI-SNTAILSAKKA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 271 GWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANNFWLSYTLLVIAGAAMYAPYgpffAIIP 350
Cdd:cd17344 250 GDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPY----ALIT 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 895908824 351 EMLP------RNVAGGAMAL------INSMGALGSFFGSWFVGYLNgATGSPAASYIFMGVALFASVWLTLIVK 412
Cdd:cd17344 326 TAVSadlgthKSLKGNARALatvtaiIDGTGSIGAALGPLLAGLIS-SRGWNNVFYMLIAADVCAGLLLTRLVY 398
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
79-383 |
8.41e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.41 E-value: 8.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 79 RKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVvEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVS 158
Cdd:cd17504 61 KKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGI-GGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 159 GYLIQALGWREMFIIeGFPAIIWAFFWWVLVKDKpsqagwltesekaalqaqlekeqqgikavrnyseAFRSRNVILLCM 238
Cdd:cd17504 140 GWIVQHLGWRWIFWT-AAPVAVLLAALVPLIDLR----------------------------------LLRRRNVLLANI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 239 QYFTWSIGVYGFVLWLPSIIRSGSA---NMGMVEVGWLssvpYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIG 315
Cdd:cd17504 185 TALLAGFGMFMVFQLLPQLLQLPTPtgfGLGITEAGLL----LLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVG 260
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 316 SWAVGANNF--WLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYL 383
Cdd:cd17504 261 LLLLALLHSslWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
52-407 |
8.67e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 41.48 E-value: 8.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 52 SLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTG---MVSNIPMLAAIRFILGVVEAAVMPAMLIYIS 128
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFlskSAKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 129 NWFTKSERSRANTFLILGNPVTVLWMSVVSgyLIQALG----WREMFIIEGFPAIIWAFFWW---------VLVKDKPSQ 195
Cdd:cd17357 132 EISPSELRGALGSLTQIGVTLGILLGQVFG--LPSVLGtetlWPYLLFFPGIPALLQLAALPffpespkflLISKGDEEE 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 196 A--------GWLTESEKAALQAQLEKEQQGIKAVRNYSEAFRSRN--------VILLCMQYFT--WSIGVYGFvlwlpSI 257
Cdd:cd17357 210 AekslkflrGIEDDVDQELEEIKKESEQMGDQKQVSLMQLLRDPSlrlplllvLVVSASQQFSgiNAIFFYST-----FI 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 258 IRSgsANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFI--GSWAVGANNFWLSYTLLV--- 332
Cdd:cd17357 285 FEN--AGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLmsVFLFLSEQNSWMSYGCIVaif 362
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 895908824 333 --IAGAAMYAPYGPFFaIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGAtGSPAASYIFMGVALFASVWL 407
Cdd:cd17357 363 lfIFFFAIGLGPIPWF-IGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSI-GGGFVFIIFAIPCALFLLYL 437
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
280-413 |
9.93e-04 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 41.21 E-value: 9.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 280 AATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAF-IGSWAVGANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVA 358
Cdd:cd17368 270 ANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYpVFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVR 349
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 895908824 359 GGAMALINSMG-ALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLTLIVKP 413
Cdd:cd17368 350 STGFSLVYALAvAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAALLGLLATLMLRE 405
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
51-411 |
1.02e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 41.18 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 51 SSLLGALFFlgyfffQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNW 130
Cdd:cd17362 47 GSLLGALLG------SLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAET 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 131 FTKSER----SRANTFLILGnpvtvLWMSVVSGYLIQAL--GWREMFIIEGFPAIIWAFFWWvlvkdkpsqagWLTESEK 204
Cdd:cd17362 121 SPSHIRgllvSLKELFIVLG-----ILLGYVSGYAFADVvgGWRYMYGLAAPPALLLGIGMW-----------FLPPSPR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 205 aalqaqlekeqqgikavrnYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRSG--SANMGMVEVGWLSSVPYLAAT 282
Cdd:cd17362 185 -------------------WQGNYRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAgfSAASDATLVSVGLGVFKLLMT 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 283 -IAMIVVswasDKLQNRKLF-------VWPLLLIAAFAFIGSwAVGANNFWLSYTLLVIAGAAMYAPYGPF-FAIIPEML 353
Cdd:cd17362 246 iVAVLLV----DKLGRRPLLlggvsgmVVSLFLLAAYNLFVQ-MGPAGLAWLSLVALLLYVGAYQISFGPIsWLMVSEIF 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 895908824 354 PRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLTLIV 411
Cdd:cd17362 321 PLRVRGRAIALAVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIYFTV 378
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
52-401 |
1.06e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.15 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 52 SLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWF 131
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 132 TKSERSR---ANTFLILGNPVTVLWMSVVsgyLIQALGWREMFIIEGFPAIIWAFFWWVLvkdkpsqagwltesEKAALQ 208
Cdd:cd17333 114 EESSATRlnvLHGFFGLGALIGPLIATSL---LTSELSWSWAYLIIGLIYLLLAILILLT--------------LFPELP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 209 AQLEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRsGSANMGMVEVGWLSSVPYLAATIAMIVV 288
Cdd:cd17333 177 SARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLV-EKKHVSDGLAGYLLSGFWVGITIGRLLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 289 SWASDKLQNRKLFVWPLLLIAAFAFIGSWavgANNFWLSYTLLVIAGAAMYAPYGPFFAIIPEMLPRNvAGGAMALINSM 368
Cdd:cd17333 256 GPISRRIKPHTLLVLSGSGALLGLLILLL---APTLVVGLVATALLGLFMAALFPTILSLGISNLPYA-KGKGTSVLLAA 331
|
330 340 350
....*....|....*....|....*....|...
gi 895908824 369 GALGSFFGSWFVGYLNGATGSPAASYIFMGVAL 401
Cdd:cd17333 332 GSIGGAIIPFIMGFIAEAVGIQTAMLLITILYA 364
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
254-410 |
1.59e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.64 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 254 LPSIirSGSANMGMVEVGWLSSVPYLAATIAMIVVSWASDKLQNRKLFvwpllLIAAFAF-IGSWAVG-ANNFWLSYTLL 331
Cdd:cd17503 19 LPTI--MGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLF-----LTALALFtLGSLLCGlAPNLASLIIFR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 332 VI--AGAAMYAPYGpfFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPAASYIFMGVALFASVWLTL 409
Cdd:cd17503 92 ILqgFGGGVLIPLA--QTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPL 169
|
.
gi 895908824 410 I 410
Cdd:cd17503 170 L 170
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
79-411 |
1.89e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 40.24 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 79 RKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTF--------LILGNPVT 150
Cdd:cd17359 66 RKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLnqlmivfgQLLAYIVN 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 151 VLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWWVLvkdkPSQAGWLTESEKAALQAQ--LEKEQQ--GIKAVRNYSe 226
Cdd:cd17359 146 YLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFI----PESPRWLVSKGKPILIIGigLAIFQQfvGINVIFYYG- 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 227 afrsrnvillcmqyftwsigvygfvlwlPSIIRS--GSANMGMVEVGWLSSVPYLAATIAMIVVswasDKLQNRKLFVWP 304
Cdd:cd17359 221 ----------------------------PEIFQNagFSENAALLQTIGIGVVNVIFTIIAILLV----DKVGRKPLLLIG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 305 LLLIAAFAFIGSWA-----VGANNFWLSYTLLVIAGAAMYAPYGPF-FAIIPEMLPRNVAGGAMALINSMGALGSFFGSW 378
Cdd:cd17359 269 SIGMAISLLLIGTAfyfapGSQASGIVALVLILLFVAFFAMSWGPVtWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSL 348
|
330 340 350
....*....|....*....|....*....|...
gi 895908824 379 FVGYLNGATGSPAASYIFMGVALFASVWLTLIV 411
Cdd:cd17359 349 TFPILLAAFGLAFTFLIFAVICVLAFLFVWKFV 381
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
253-424 |
2.56e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.85 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 253 WLPSIIRSGSANMGMVevGWLSSVPYLAATIAMIVVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAvgaNNFWLSYTLLV 332
Cdd:cd17478 18 LLPLLIAKLGLSYAQA--GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA---PNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 333 IAGA--AMYAPYGpffAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPaASYIFMGVALFASVWLTLI 410
Cdd:cd17478 93 LAGIgsAAFHPEG---ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGL-GLLILLIIPGLAVALLLLR 168
|
170
....*....|....
gi 895908824 411 VKPANNQQLPIGAR 424
Cdd:cd17478 169 LRPLKKPEAKKAAA 182
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
40-186 |
3.39e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.51 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMV--SNIPMLAAIRFILGVVEA 117
Cdd:cd17316 204 LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVG 283
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 118 AVMPAMLIYISNWFTKSERSRANTFLI-LGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFFWW 186
Cdd:cd17316 284 GVWGALYAYLAELFPTEVRATGVGLSYnLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
42-259 |
6.18e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 38.75 E-value: 6.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 42 EDLGITKGISSLLGALFFLGYFFFQIPGAVYAERRSVRKLIFICLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd17438 27 KDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 122 AMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGW-------------REMFIIEGFPAIIWAffwwVL 188
Cdd:cd17438 107 IVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWgfsmgtnyhfhswRVFVIICALPCIASI----IA 182
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 895908824 189 VKDKPSQAGWLTESEKAALQAQLEKE-------QQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIR 259
Cdd:cd17438 183 LKFMPESPRFLLEMGKHDEAWMILKNihdtnmrAKGTPEKVFTVSNIKRKNTLFLAVVWFTMAFSYYGLTVWFPDMIR 260
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
244-412 |
6.67e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 38.64 E-value: 6.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 244 SIGVYGFVLWLPSIIrsgSANMGMVEVGWLS--SVPYLAATIAMIVVSWASDKLQNRKLFVWpllliaaFAFIGSwAVGA 321
Cdd:cd17337 221 TLSQFGFPVFMPLYF---TDTGGFSTSQWLQiwGIIFLVNIFFNLIFGILGDKIGWRRTVRW-------FGGVGC-AIST 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 895908824 322 -----------NNFWLSYTLLVIAGAAMyAPYGPFFAIIPEMLPRNvAGGAMALINSMGALGSFFGSWFVGYLNGATGSP 390
Cdd:cd17337 290 llfyyvpqlfgHNYWAALIAAILFGIGL-AGFVPLSALMPSLAPEH-KGAAMSILNLGAGLSNFVGPAIVTLFLGSFGAG 367
|
170 180
....*....|....*....|..
gi 895908824 391 AASYIFMGVALFASVwLTLIVK 412
Cdd:cd17337 368 GVVWIFAGLYLLSAV-LTLFLK 388
|
|
|