|
Name |
Accession |
Description |
Interval |
E-value |
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
5-368 |
2.69e-33 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 127.29 E-value: 2.69e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 5 RVIFLSASSFFLSYFSRVAWSIVAPLF--TLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTS 82
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLqaDLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 83 FVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYF 162
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 163 ISVFSIILGILALVFLpslklskSIIKFkdvirdknSIYISIGGFLFYLTYWVLVLYLYkyllgvvrNEYVAGIIYSLTA 242
Cdd:COG2271 170 LGLPGLLLALLRFWLL-------ALAYF--------LVYFALYGFLTWLPTYLVEVRGL--------SLAQAGLLLSLPF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 243 LTGIFSTILAGYIIKSLGVKRTFLLFIS--LYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERSG 320
Cdd:COG2271 227 LAGIVGSLLGGWLSDRLGRRRKLVLAIGllLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARG 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 850525840 321 SVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLWTFVSVLSFLSLIFY 368
Cdd:COG2271 307 TASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-331 |
8.91e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 108.91 E-value: 8.91e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 4 KRVIFLSASSFFLSYFSRVAWSIVAPLFT--LKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVT 81
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAadLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 82 SFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFY 161
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 162 FISVFSIILGILALVFLPS---LKLSKSIIKFKDVIRDKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVV-RNEYVAGII 237
Cdd:COG2814 169 VNAVLALLALLLLLRLLPEsrpAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLgLSASAAGLL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 238 YSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKE 317
Cdd:COG2814 249 LALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPE 328
|
330
....*....|....
gi 850525840 318 RSGSVTGFANFFWQ 331
Cdd:COG2814 329 ARGRASGLYNSAFF 342
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-372 |
7.40e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 107.27 E-value: 7.40e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 5 RVIFLSASSFFLSYFSRVAWSIVAPLFT--LKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTS 82
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAeeFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 83 FVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYF 162
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 163 ISVFSIILGILALVFLPSLKL------SKSIIKFKDVIRDKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYV-AG 235
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDPPAgaaaaaKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAtAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 236 IIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTA-VAVIG 314
Cdd:COG2223 245 LLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFAlVPDIF 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 850525840 315 GKERSGSVTGFANFFWQSSGIVGSIIAPLLINLF-TYTYLWTFVSVLSFLSLIFYYKLK 372
Cdd:COG2223 325 PTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
5-368 |
1.11e-23 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 100.72 E-value: 1.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 5 RVIFLSASSFFLSYFSRVAWSIVAPLFT--LKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTS 82
Cdd:cd17319 3 RIIPLLFLAYVINYLDRVNISVAAPTIMkdLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 83 FVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYF 162
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 163 ISVFSIILGILALVFLPSLklsksiikFKDVIrdknsIYISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTA 242
Cdd:cd17319 163 EGLLGLLLAVLWWFYLRQV--------WGLAL-----GYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 243 LTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALAlGFFRFIITPTSSTAVAVIGGKERSGSV 322
Cdd:cd17319 230 IGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLA-GFGIGAASPVFWSLPADLLPGEAAATA 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 850525840 323 TGFANFFWQSSGIVGSIIAPLLINLF-TYTYLWTFVSVLSFLSLIFY 368
Cdd:cd17319 309 GGLINSGGNLGGFVAPLLIGYLVDATgSYTAAFLFLAAVALLAALLV 355
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-372 |
3.75e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 96.49 E-value: 3.75e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 22 VAWSIVAPLF-----TLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYL 96
Cdd:cd17325 10 LGYGIIIPILplyaeSLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 97 ASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGILALV 176
Cdd:cd17325 90 ARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 177 FLP---------SLKLSKSIIKFKDVIRDKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVR-NEYVAGIIYSLTALTGI 246
Cdd:cd17325 170 LLPeprpppnkrAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 247 FSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERSGSVTGFA 326
Cdd:cd17325 250 LSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 850525840 327 NFFWQSSGIVGSIIAPLLINLFTYTYLWTFVSVLSFLSLIFYYKLK 372
Cdd:cd17325 330 NTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-338 |
3.89e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 87.47 E-value: 3.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 11 ASSFFLSYFSRVAWSIVAPLF---TLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSAT 87
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlaeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 88 FPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFS 167
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 168 IILGILALVFLP---------SLKLSKSIIKFKDVIRDKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIY 238
Cdd:pfam07690 162 LLAAVLLLLPRPppeskrpkpAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 239 SLTALTGIFSTILAGYIIKSLGVKRT---FLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGG 315
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRlllALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
|
330 340
....*....|....*....|...
gi 850525840 316 KERSGSVTGFANFFWQSSGIVGS 338
Cdd:pfam07690 322 KEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
13-369 |
3.26e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 79.39 E-value: 3.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 13 SFFLSYFSRVAWSIVAPLFT--LKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPL 90
Cdd:cd06174 4 GFFLTGLARGLISPLLPALLqsFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 91 ITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLA--LTFSWEFSFYFISVFSI 168
Cdd:cd06174 84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 169 ILGILALVFLPSLKLSKSIIK-----------FKDVIRDKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVRN-EYVAGI 236
Cdd:cd06174 164 LAAILLLLVVPDPPESARAKNeeassksvlklLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLsVAVAGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 237 IYSLTALTGIFSTILAGYII-KSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGG 315
Cdd:cd06174 244 LLSLFGLAGALGSLLLGLLSdRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 850525840 316 KERSGSVTGFANFFWQSSGIVGSIIAPLLINL-FTYTYLWTFVSVLSFLSLIFYY 369
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
41-367 |
1.53e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 74.12 E-value: 1.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 41 SIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSF 120
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 121 DDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGILALVFLPSLKLSKS-----IIKFKDVIR 195
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPgslglLSSLLLLLR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 196 DKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVRN-EYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSF 274
Cdd:cd17324 197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFsSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 275 SLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERsGSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLW 354
Cdd:cd17324 277 LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355
|
330
....*....|...
gi 850525840 355 TFVSVLSFLSLIF 367
Cdd:cd17324 356 WVGAALLLLALLL 368
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
14-371 |
6.80e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 69.14 E-value: 6.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 14 FFLSYFSRVAWSIVAPLFT-----LKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATF 88
Cdd:cd17474 5 FFATLLAVLGVSIVDPILPaiaeaLGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 89 PLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALtFSWEFSFYFISVFSI 168
Cdd:cd17474 85 DSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 169 ILGILALVFLPSLKLSK------SIIKFKDVIRDKNSIYISIGGFLFYLTYWVLVLYL-YKYLLGVVRNEYVAGIIYSLT 241
Cdd:cd17474 164 VAFLAILFLLPEPKEKAksssatKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLpFLLELLYGISPIIIGLLFAGW 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 242 ALTGIFSTILAGYIIKS-LGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERSG 320
Cdd:cd17474 244 SVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERG 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 850525840 321 SVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLWTFVSVLSFLSLIFYYKL 371
Cdd:cd17474 324 TASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
4-375 |
8.96e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.73 E-value: 8.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 4 KRVIFLSASSFFLSYFSRVAWSIVAPLF--TLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVT 81
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPALkdAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 82 SFVSATFPLITVEYLASFLMGFSAGWIYpITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLA---LTFSWEF 158
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLLGLGLGLLD-VAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLIllgLSLSWHL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 159 SFYFISVFSIILGILALVF-LPSLK-----LSKSIIKFKDVIRDKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVR-NE 231
Cdd:COG0738 166 PYLILAVLLLLLALLFLRSkLPEIEeeeeeAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGlSE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 232 YVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVA 311
Cdd:COG0738 246 ATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLAL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 850525840 312 VIGGKERSGSVTGFAnffwqSSGIVGSIIAPLLINLF--TYTYLWTFVSVLSFLSLIFYYKLKFMR 375
Cdd:COG0738 326 DGLGKRTAAAVSAVL-----IMGIVGGAIGPPLIGFLadAFGLRAAFLVPLVCYLLILLLALALKR 386
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
48-367 |
1.07e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 68.42 E-value: 1.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 48 FLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPI 127
Cdd:cd17475 41 NLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 128 AMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGILALVFL-----PSLKLSKSIIKF---KDVIRDKNS 199
Cdd:cd17475 121 AMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYreppaASAATESASTLLrslKEVLRNRDV 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 200 IYISIGGFL------FYLTYWVLVLYLYKYLlgvvrNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKR-----TFLLF 268
Cdd:cd17475 201 WLIAIAGALlvapqfALLTFLLLFLHDHLGL-----SVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRrrpvlVITAA 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 269 ISLYSFSLLIF--SFTKNVMVMGIDALaLGFFRFIITPTSSTAVAVIGGKERSGSVTGFANFFWQSSGIVGSIIAPLLIN 346
Cdd:cd17475 276 IAAAALLVLSLlsPGTPLWLLVLLLIL-LGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVD 354
|
330 340
....*....|....*....|..
gi 850525840 347 -LFTYTYLWTFVSVLSFLSLIF 367
Cdd:cd17475 355 aTHSYAPAWLALALLLVLAALL 376
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
14-355 |
1.44e-12 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 68.17 E-value: 1.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 14 FFLSYFSRVAWSIVAPLF--TLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLI 91
Cdd:TIGR00881 4 YAAYYLVRKNFALAMPYLveEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 92 TVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLS-IVASGIVIPFLALTFSWEFSFYFISVFSIIL 170
Cdd:TIGR00881 84 WVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGgGLLPPLVLFGIAELYSWHWVFIVPGIIAIIV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 171 GILALVF---------LPSLK-----------------LSKSIIKFKDVIRDKNSIYISIGGFLFYLTYWVLVLYLYKYL 224
Cdd:TIGR00881 164 SLICFLLlrdspqscgLPPAEempneepdgdaekkeeeLTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 225 LGVVR-NEYVAGIIYSLTALTGIFSTILAGYII--------KSLGVKRTFLLFISLYSFSLLIFSftkNVMVMGIDALAL 295
Cdd:TIGR00881 244 TQEKGfSKEKASWAFTLYELGGLVGTLLAGWLSdklfngrrGPLAVFFMALIIVSLLVYWLNPAA---NPLMDLICLFAL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 296 GFFRFIITPTSSTAVAVIGGKERSGSVTGFANFFwqssGIVGSIIAPLLINLFTYTYLWT 355
Cdd:TIGR00881 321 GFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFF----AYLGGILAGLPLGYLADGFGWA 376
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
21-367 |
1.46e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 68.36 E-value: 1.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 21 RVAWSIVAPLF-----TLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEY 95
Cdd:COG2807 31 RPAITSVGPLLpeiraDLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 96 LASFLMGFSAGWIYPITVKLLSTSFDDKdLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGILAL 175
Cdd:COG2807 111 AGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 176 VFLPSLK----LSKSIIKFKDVIRDKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTIL 251
Cdd:COG2807 190 PLLRRRPaaaaAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 252 AGYIIKSLGVKRTFLLFIS-LYSFSLLIFSFTKNVMVMgidaLALGFFRFIITPTSSTAVAVIGGKERSGSVTGFANFFW 330
Cdd:COG2807 270 VPLLADRLGDRRPLLLLLGlLGLAGLLGLLLAPGSLPW----LWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMA 345
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 850525840 331 QSSGIVGSIIAPLLINLF-----TYTYLWTFVSVLSFLSLIF 367
Cdd:COG2807 346 QSVGYLLAALGPLLVGALhdatgSWTAALLLLAALAVLMLVA 387
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
41-371 |
1.39e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 65.33 E-value: 1.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 41 SIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVE-----YLASFLMGFSAGWIYPITVKL 115
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLslwllLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 116 LSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYfISVFSIILGILALVFLP-----------SLKLS 184
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA-INALSFLLSALLLLFIRrpppaapgessSLLLR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 185 KSIIKFKDVIRDKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVR-NEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKR 263
Cdd:cd06173 196 DLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGgGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 264 TFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERSGSVTGFANFFWQSSGIVGSIIAPL 343
Cdd:cd06173 276 LLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL 355
|
330 340
....*....|....*....|....*...
gi 850525840 344 LINLFTYTYLWTFVSVLSFLSLIFYYKL 371
Cdd:cd06173 356 LADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
32-349 |
1.99e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 64.50 E-value: 1.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 32 TLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPI 111
Cdd:cd17321 25 DLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 112 TVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYfisvFSIILGILALVFLPSLKLSkSIIKFk 191
Cdd:cd17321 105 SLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFL----INVPIGLVALLLARTFSGA-VLAAF- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 192 dvirdknSIYISIGGFLFYLTYWVLVLYLykyllgvvRNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRT-----FL 266
Cdd:cd17321 179 -------LLGAALGGLLFLLPLYLQGVLG--------YSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVlvaglLL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 267 LFISLYSFSLLIFSFTKNVMVMGIDALALGfFRFIITPTSSTAVAVIgGKERSGSVTGFANFFWQSSGIVGSIIAPLLIN 346
Cdd:cd17321 244 TAVGLLLLALLGADSSVWLLLPGLVLLGLG-LGLFATPLTNAALSSV-PKEKAGAASGILNTARQLGGALGVALLGALLT 321
|
...
gi 850525840 347 LFT 349
Cdd:cd17321 322 AGL 324
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
4-367 |
3.88e-11 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 63.83 E-value: 3.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 4 KRVIFLSAS-SFFLSYFSRVAWSIVAPLF--TLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAV 80
Cdd:cd17312 1 RWRIFLGVFlGYAAYYVCRKNFSVAKPPIveEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 81 TSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSF 160
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 161 YfisvfsiILGILALVFlpslklskSIIKFKDVI-RDKNSIYISIGGFLFYL-----TYWVLVLYLYKYLLGVVrneyVA 234
Cdd:cd17312 161 L-------VPGIVGLVV--------AIILFFFLRdSPPYVWVLSLAYAFVYIvryacLDWGPLYLYEVKGYSLI----DA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 235 GIIYSLTALTGIFSTILAGYIIKSLGVKRTF---LLFISLYSFSLLIFSFTKNVMVMGIDALAL-GFFRFIITPTSSTAV 310
Cdd:cd17312 222 GWFSSLYEVGGIAGTILAGLLSDKLFGGRRApiaVIYMLLMTLSLALFWFFPHNKLLSIVLLFLiGFFVGGPINLIGGAA 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 850525840 311 AV-IGGKERSGSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLWTFVSVLSFLSLIF 367
Cdd:cd17312 302 AQdIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLL 359
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
42-368 |
1.29e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 62.23 E-value: 1.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 42 IIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFD 121
Cdd:cd17489 35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 122 DKDLPIAMSIYSiawpLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGILALVFLPSLKLSKSIIK--------FKDV 193
Cdd:cd17489 115 PSRRGEGIGYYG----LATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAeeaeagtrAFRR 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 194 IRDKNSIYISIGGFLFYLTYwvLVLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYS 273
Cdd:cd17489 191 LVEKKVLPPALILFLASIAY--GAISTFLPLYAAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLA 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 274 FSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERSGSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYL 353
Cdd:cd17489 269 LGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAM 348
|
330
....*....|....*
gi 850525840 354 WTFVSVLSFLSLIFY 368
Cdd:cd17489 349 FLLAAVVVLLALVLY 363
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
7-181 |
2.03e-10 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 61.42 E-value: 2.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 7 IFLSASSFFLSYFSRVAWSIVAPLFT--LKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFV 84
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAkeFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 85 SATFPL--ITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYF 162
Cdd:cd17380 81 TPLLAYssLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170
....*....|....*....
gi 850525840 163 ISVFSIILGILALVFLPSL 181
Cdd:cd17380 161 FGLLGLLWALVWLIYLPPV 179
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
14-371 |
3.19e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 61.09 E-value: 3.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 14 FFLSYFSRVAWSIVAPLFTLKTTT------TEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVtSFVSAT 87
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQqlglsaSIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL-GFALLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 88 FPLITVEYLASFLM-GFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLaLTFSWEFSFYFISVF 166
Cdd:cd17329 84 FAHSPWLFAIALVLtGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFLAAAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 167 SIILGILALVFLPSLKLSK-------SIIKFKDVIRDKNSIYISIGGFLFYLTY-WVLVLYLYKYLLGVVRNEYVAGIIY 238
Cdd:cd17329 163 FLLAALVLLFLLPETRPKRraaekteILRGYKIVLRDRAFLLFLLASFLISLIYfQLESTLPVYVVEILGLGESLLGLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 239 SLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKER 318
Cdd:cd17329 243 ALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDK 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 850525840 319 SGSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLWTFVSVLSFLSLIFYYKL 371
Cdd:cd17329 323 RGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
4-178 |
5.69e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 60.28 E-value: 5.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 4 KRVIFLSASSFFLSYFSRVAWSIVAPLF---TLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAV 80
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYaaeLGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 81 TSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSF 160
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
170
....*....|....*...
gi 850525840 161 YFISVFSIILGILALVFL 178
Cdd:cd17325 358 LAAAALLLLAAVLFLLLR 375
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
4-281 |
8.95e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.05 E-value: 8.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 4 KRVIFLSASSFFLSYFSRVAWSIVAPLFT--LKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVT 81
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAadLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 82 SFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFY 161
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 162 FISVFSIILGILALVFLPSLKLSKSIIKFKDVIRDKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLT 241
Cdd:COG0477 173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 850525840 242 ALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSF 281
Cdd:COG0477 253 LLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
44-371 |
9.05e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 59.51 E-value: 9.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 44 FALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDK 123
Cdd:cd17320 40 LSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 124 DLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGILALVFLP--------SLKLSKSIIKFKDVIR 195
Cdd:cd17320 120 ELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPetlpeekrKPLLSSLLRAYKRVLK 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 196 DKNSI-YISIGGFLF--YLTYWVLVLYLYKYLLGVVRNEYvaGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLY 272
Cdd:cd17320 200 NRRFLgYALALGLSFagLFAYLAAAPFIYIEQLGLSPAQF--GLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 273 SFSLLIFSFTKNVMVMGIDALALGFFRFII----TPTSSTAVAVIGGKERSGSVTGFANFFWQSSGIVGSIIAPLLINlF 348
Cdd:cd17320 278 LAAALVLLLAALLGGLSLWPLVAPLFLIFFgfglIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPN-G 356
|
330 340
....*....|....*....|...
gi 850525840 349 TYTYLWTFVSVLSFLSLIFYYKL 371
Cdd:cd17320 357 TALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
41-348 |
6.50e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 6.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 41 SIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVA---VTSFVSATFPLITVeylASFLMGFSAGWIYPITVKLLS 117
Cdd:cd17473 38 PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGiggVAGLFLDSLYALLA---SRALLGIGVAGIMTLATALIG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 118 TSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLAlTFSWEFSFYfISVFSIILGILALVFLPSLKLSKSIIKFKDVIRDK 197
Cdd:cd17473 115 DYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFL-VYLLALPVLILVLLFLPEPARKSKSAASPGAATAA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 198 NS-----IYISIGGFLFYLTYWVLVLYL-YKYLLGVVRNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISL 271
Cdd:cd17473 193 ALpwkrvLPIYFLAFLAMLLFYVIPIQLpFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFAL 272
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 850525840 272 YSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERSGSVTGfanfFWQSSGIVGSIIAPLLINLF 348
Cdd:cd17473 273 MALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMG----IVTSAFFLGQFLSPLVLGPL 345
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
42-372 |
2.67e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 54.92 E-value: 2.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 42 IIFALFFLGYILIQIPSGTLADRISANRL-LFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPITVkLLSTSF 120
Cdd:cd17490 35 IILGAYGISQMLLRIPLGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTV-LYASYF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 121 DDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFiSVFSIILGILALVFLPSLKLSKSIIKF-----KDVIR 195
Cdd:cd17490 114 PPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLL-AALAGVLGFILSLFIKEERREKKPVLTelkelLSVLK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 196 DKNSIYISI-GGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTILAG-YIIKSLGVKRTFLLFISLYS 273
Cdd:cd17490 193 DKKLLFFSLlAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLLG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 274 FSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERSGSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYL 353
Cdd:cd17490 273 AYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTG 352
|
330
....*....|....*....
gi 850525840 354 WTFVSVLSFLSLIFYYKLK 372
Cdd:cd17490 353 FFVIGVIALLAAILSLAYY 371
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
58-349 |
1.20e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 52.96 E-value: 1.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 58 SGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWP 137
Cdd:cd17503 51 SGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVIL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 138 LSIVASGIVIPFLALTFSWEFSFYfisvFSIILGILALVFLPSLKLSksiikfkdVIRDKNSIYISIGGFLFYL-TYWVL 216
Cdd:cd17503 131 LAPAIGPTLGGWLTDNLSWRWIFY----INLPIGILALLLAPLLDLR--------LFKDRNFTLGLLLSFLLGLgLFGAM 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 217 VLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALG 296
Cdd:cd17503 199 FLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLF 278
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 850525840 297 F----FRFIITPTSSTAVAVIgGKERSGSVTGFANFFWQSSGIVGSIIAPLLINLFT 349
Cdd:cd17503 279 IrglgMGLVFMPLNTLALNSL-PPEQIGDATALFNTIRQLGGSIGTALLATLLTNRT 334
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
6-370 |
1.76e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 52.58 E-value: 1.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 6 VIFLSASSFFLsyFSRVAWSIVAPLFTLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVS 85
Cdd:cd17330 4 VVFLDALGFGI--VFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 86 ATFPLITVEYLASFLMGFSAGWIYPITVkLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISV 165
Cdd:cd17330 82 GLSRNLWLLFLARFLDGLTGGNVSVAQA-YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 166 FSIILGILALVFLPSLKlsksiikfkdvirdknsiYISIGGFLFYLTYWVLVLYLYKYLLGVVR-NEYVAGIIYSLTALT 244
Cdd:cd17330 161 LALLNLVLVLFFLPPLR------------------RLLLVYFLIALAFAGLESVFSLFLKDRFGfSPSQIGLLLALVGIA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 245 GIFSTIL-AGYIIKSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERSGSVT 323
Cdd:cd17330 223 GILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQ 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 850525840 324 GFAnffwQSSGIVGSIIAPLLINLFTYTYL----WTFVSVLSFLSLIFYYK 370
Cdd:cd17330 303 GII----QSLQSLARIIGPLLAGPLYSFLGpgvpFLLAAGLLLIALFLLSL 349
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
36-179 |
2.82e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 51.85 E-value: 2.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 36 TTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYL--ASFLMGFSAGWIYPITV 113
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALivLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 850525840 114 KLLSTSFDDKDLpiaMSIYSIAWPLSIVASGIVIP---FLALTFSWEFSFYFISVFSIILGILALVFLP 179
Cdd:cd17318 134 ALWAKWAPPLER---SRLTSIAYSGSQFGTVIAMPlsgFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
41-179 |
3.51e-07 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 49.19 E-value: 3.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 41 SIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSF 120
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 850525840 121 DDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGILALVFLP 179
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
18-367 |
3.58e-07 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 51.86 E-value: 3.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 18 YFSRVAWSIVAPLF--TLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEY 95
Cdd:cd17345 16 YLVRNNFSLAQPYLieQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 96 LASFLMGFSAGWI----YPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTF---SWEFSFYFISVFSI 168
Cdd:cd17345 96 GLMFILLFLNGWFqgmgWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgdgWWRGAFIFPAIIAI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 169 ILGILALVF---------LPSL------------------KLSKSIIKFKDVIRDKNSIYISIGG-FLFYLTYWVLVLYL 220
Cdd:cd17345 176 IVAVIVLFLgkdtpesegLPPIeeykgdypeeadgeeeeqELSAWEIFVKYVLKNKLLWYIAIANvFVYLVRYGILDWAP 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 221 YKYLLGVVRNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKR---TFLLFISLYSFSLLIFSFTKNVMVMGIDALALGF 297
Cdd:cd17345 256 TYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRrapTGIIFMILVIVALIVYWLAPNVLVDLIALIALGF 335
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 298 FRFIITPTSSTAVAVIGGKERSGSVTGFANFFwqsSGIVGSIIAPLLINLFTYTYLWTFVSVLSFLSLIF 367
Cdd:cd17345 336 LIYGPVMLIGLQALELVPKKAAGTAAGLTGLF---GYLGGSVLATALIGIIVDHFGWNGGFIVLLASCIL 402
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
15-174 |
6.05e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.02 E-value: 6.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 15 FLSYFSRVAWSIVAPLFTLKTTTTED--SIIFALFFLGYILIQIPSGTLADRISANR-LLFLSLLGVAVTSFVSATFPLI 91
Cdd:cd17477 198 FVAGFLEGAFYSLLPLYGLRLGLSVAqaALLLAAFVLGGLLLQWPLGWLADRFDRRRvLLGCALLGALAALLLPLVPGLP 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 92 TVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILG 171
Cdd:cd17477 278 LALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFL 357
|
...
gi 850525840 172 ILA 174
Cdd:cd17477 358 LFL 360
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
33-368 |
1.35e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 49.88 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 33 LKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGwIYPIT 112
Cdd:cd17504 26 FGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGA-VFPLA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 113 VKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGILALVFLPSLKLSKSIIKfkd 192
Cdd:cd17504 105 FALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDLRLLRRRNVLL--- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 193 virdKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLY 272
Cdd:cd17504 182 ----ANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVIS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 273 SFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIG-GKERSGSVTGFANFFWQSSGIVGSIIAPLLINLFTYT 351
Cdd:cd17504 258 AVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESvPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVS 337
|
330
....*....|....*..
gi 850525840 352 YLWTFVSVLSFLSLIFY 368
Cdd:cd17504 338 ITSGGVPTEGAYVLAFL 354
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
7-363 |
1.64e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.52 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 7 IFLSASSFFLSYFSRVAWSIVAP----LFTLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTS 82
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPvlaaEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 83 FVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYF 162
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 163 ISVFSIILGILALVFLPSLKLSKSIIKFkdvirdknsIYISIGGFLFYLTYWVLVLYLYkyllgvvrNEYVAGIIYSLTA 242
Cdd:cd17316 161 LFLIGALPALLALLLRRRTLLLILLWFF---------ISFGYYGLTTFLPTYLQTVLGL--------SPATSSLYLLLIS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 243 LTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIF--SFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERSG 320
Cdd:cd17316 224 LGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLfyLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRA 303
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 850525840 321 SVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLWTFVSVLSFL 363
Cdd:cd17316 304 TGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
41-348 |
5.50e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.09 E-value: 5.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 41 SIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSF 120
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 121 dDKDLPIAMSIYSIAWPL-SIVASGIVIPFLALTFSWEFSFYFISVFSIILGILALVFL------PSLKLSKSIIKFKDV 193
Cdd:cd17333 114 -EESSATRLNVLHGFFGLgALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLfpelpsARNPQQSVGAFSASA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 194 IRDKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVR----NEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFI 269
Cdd:cd17333 193 SRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEkkhvSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSG 272
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 850525840 270 SLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTaVAVIGGKERSGSVTGFANFFwqssGIVGSIIAPLLINLF 348
Cdd:cd17333 273 SGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILS-LGISNLPYAKGKGTSVLLAA----GSIGGAIIPFIMGFI 346
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
42-367 |
1.55e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 46.44 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 42 IIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGfsAGWIYPITVKLLSTSFD 121
Cdd:cd17472 36 LALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG--SGAISSVVMALLADLTR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 122 DKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGILALVFLPSLKLSKSII-----KFKDVIRD 196
Cdd:cd17472 114 EENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISekekkKLKKLLKN 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 197 KNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTILAGYIIKSLG-VKRTFLLFISLYSFS 275
Cdd:cd17472 194 KRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGkMKQVFVSSILLIAVG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 276 LLIFSFTKNVMVMGIDALALGFFRF-IITPTSSTAVAVIGGKERSGSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLW 354
Cdd:cd17472 274 FLLLLFAATSLWLLIIGLIIFFIGFnLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVF 353
|
330
....*....|...
gi 850525840 355 TFVSVLSFLSLIF 367
Cdd:cd17472 354 LTILILALLWLLV 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
202-367 |
1.65e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.51 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 202 ISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSF 281
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 282 TKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERSGSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLWTFVSVLS 361
Cdd:COG2814 95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLA 174
|
....*.
gi 850525840 362 FLSLIF 367
Cdd:COG2814 175 LLALLL 180
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
128-351 |
2.23e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.05 E-value: 2.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 128 AMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGILALVFLPSLKLSKSIIK-----------FKDVIRD 196
Cdd:COG2211 148 LSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVpeeekvslkesLKALLKN 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 197 KNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVRNEY-VAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFS 275
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAaLVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 276 LLIFSF--TKNVMVMGIDALALGFFRFIITPTSSTAVA-------VIGGKERSGSVTGFANFFWQSSGIVGSIIAPLLIN 346
Cdd:COG2211 308 LLLLFFlgPGNLWLLLVLAALAGIGLGAILVLPWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
....*
gi 850525840 347 LFTYT 351
Cdd:COG2211 388 LFGYV 392
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
43-298 |
3.41e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.43 E-value: 3.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 43 IFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDD 122
Cdd:TIGR00895 57 LFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPK 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 123 KDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGILALVFLP----------------------- 179
Cdd:TIGR00895 137 RFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPesidflvskrpetvrrivnaiap 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 180 --------SLKLSKSIIKFKDVIRD--------KNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTAL 243
Cdd:TIGR00895 217 qmqaeaqsALPEQKSTQGTKRSVFKalfqgktaRITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNF 296
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 850525840 244 TGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFF 298
Cdd:TIGR00895 297 GGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFF 351
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-182 |
4.16e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.25 E-value: 4.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 7 IFLSASSFFLSYFSRVAWSIVAPLF---TLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANR--LLFLSLLGVAVT 81
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYlveVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 82 SFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFY 161
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170 180
....*....|....*....|.
gi 850525840 162 FISVFSIILGILALVFLPSLK 182
Cdd:COG2271 342 LLAALALLAALLALLLLRETR 362
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
46-366 |
4.79e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 45.07 E-value: 4.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 46 LFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDL 125
Cdd:TIGR00710 48 LYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEEL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 126 PIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGILALVFLPSLK-------LSKSIIKFKDVIRDKN 198
Cdd:TIGR00710 128 SRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLpyeariqISTYFETFLLLLKSKM 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 199 SI-YISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLL 277
Cdd:TIGR00710 208 FWgYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAV 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 278 IFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERSGSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLWTFV 357
Cdd:TIGR00710 288 LLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMS 367
|
....*....
gi 850525840 358 SVLSFLSLI 366
Cdd:TIGR00710 368 LSCLVLAVV 376
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
18-175 |
5.35e-05 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 44.70 E-value: 5.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 18 YFSRVAWSIVAP--LFTLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEY 95
Cdd:cd17488 16 YLTRKSFNAAMPamLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 96 LASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGILAL 175
Cdd:cd17488 96 VLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAILMGIVLC 175
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
233-369 |
5.70e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.72 E-value: 5.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 233 VAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAV 312
Cdd:pfam07690 33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 850525840 313 IGGKERSGSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLWTFVSVLSFLSLIFYY 369
Cdd:pfam07690 113 WFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL 169
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
150-367 |
1.92e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 150 LALTFSWEFSFYFISVFSIILGILALVFL--------PSLKLSKSIIKFKDVIRDKNSIYISIGGFLFYLTYWVLVLYLY 221
Cdd:cd17370 145 ALLLYLLGGNYRTIFLLAAIPALLALLILlfvvkeypRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLIL 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 222 KYLLGVVrNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFI 301
Cdd:cd17370 225 RAQELGL-SAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGA 303
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 850525840 302 ITPTSSTAVAVIGGKERSGSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLWTFVSVLSFLSLIF 367
Cdd:cd17370 304 QESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
242-366 |
2.15e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 43.00 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 242 ALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKER--S 319
Cdd:cd17313 291 SLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGrgQ 370
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 850525840 320 GSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLWTFVSVLSFLSLI 366
Cdd:cd17313 371 GTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLV 417
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
202-376 |
2.29e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 202 ISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSF 281
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 282 TKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERSGSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLWTFVSVLS 361
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170
....*....|....*
gi 850525840 362 FLSLIFYYKLKFMRD 376
Cdd:cd06174 161 LALLAAILLLLVVPD 175
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
42-367 |
3.90e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.16 E-value: 3.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 42 IIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFD 121
Cdd:cd17477 35 LVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALAT 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 122 DKDLPIAMSIYSIAWPLSIVASGIVIPFLAlTFSWEFsFYFISVFsIILGILALVFLPSL---KLSKSIIKFKDVIRdkN 198
Cdd:cd17477 115 NENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGALP-FLIAAVL-LLLALVPLLLTRRAapeIEEAESISLRRLLR--I 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 199 SIYISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLI 278
Cdd:cd17477 190 APLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 279 FSFTKNVM-VMGIDALALGFFRFIITPTSSTAVAVIGGKERSGSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLWTFV 357
Cdd:cd17477 270 LPLVPGLPlALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFL 349
|
330
....*....|
gi 850525840 358 SVLSFLSLIF 367
Cdd:cd17477 350 AAVALLFLLF 359
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
47-345 |
4.13e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.22 E-value: 4.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 47 FFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLP 126
Cdd:cd17328 43 FIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 127 IAMSIYSIAWPLSIVASGIVIPFLA-LTFSWEFSFYFISVFSIILGILALVFLP-------------SLKLSKSIIKFKD 192
Cdd:cd17328 123 RALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLAILLLLFVRepprgaaeggvmaKSTATSFLADLKA 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 193 VIRDKNSIYISIGGFL-----FYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKR---- 263
Cdd:cd17328 203 LAKNPSFILSTLGFTAvsfvtGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTprad 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 264 ----TFLLFISLYSFSLLIFSFTKNVMVM-GIDALALGFFRFIITPTSSTAVAVIGGKERSgSVTGFANFFwqsSGIVGS 338
Cdd:cd17328 283 plvcAVGLLAAAPFLFLALVLALSNLLLAwVLLFLGEFLLSLNWAPVFAILLYVVIPTRRS-TASAIQILL---SHLLGD 358
|
....*..
gi 850525840 339 IIAPLLI 345
Cdd:cd17328 359 AGSPYLI 365
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
202-373 |
6.27e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 6.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 202 ISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSF 281
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 282 TKNVMVMGIDALALGFFRFIITPTSSTAVAVIGGKERSGSVTGFANFFWQSSGIVGSIIAPLLINLFTYTYLWTFVSVLS 361
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170
....*....|..
gi 850525840 362 FLSLIFYYKLKF 373
Cdd:cd17489 161 LLALLLVFLVKD 172
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
18-173 |
9.28e-04 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 41.23 E-value: 9.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 18 YFSRVAWSIVAP--LFTLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTS----FVSATFPLI 91
Cdd:PRK11663 36 YFTRKSFNAAMPemLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINilfgFSSSLWAFA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 92 TVEYLASFLMgfsaGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILG 171
Cdd:PRK11663 116 LLWVLNAFFQ----GWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVG 191
|
..
gi 850525840 172 IL 173
Cdd:PRK11663 192 LF 193
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
33-179 |
1.85e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 39.92 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 33 LKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSA---TFP-LITVEylasFLMGFSAGWI 108
Cdd:cd17327 36 LKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAavkNFGgLIALR----FFLGLFESGV 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 850525840 109 YPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIV------IPFLALTFSWEFSFYFISVFSIILGILALVFLP 179
Cdd:cd17327 112 FPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLaygvfkILGVGGLAGWRWLFIIEGLITIIIGLVIFFWLP 188
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
41-366 |
1.92e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.95 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 41 SIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGF-SAGWIYPITVKLLSTS 119
Cdd:cd17355 41 SLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGgGAGTLAAVAFATVAAW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 120 FDDKDLPIAMSIYSIAwplSIVASGIVIPFLAL---TFSWEFSFYFISVFSIILGILALVFL------------PSLKLS 184
Cdd:cd17355 121 WFERRRGLALGILTAG---GGLGSLVFLPLGAAlieAFGWRTALLVLALLALLVLVPVLLLLrrrpadlalrayDDASPA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 185 KSIIKFKDVIRDKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRT 264
Cdd:cd17355 198 SPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 265 FLLFISLYSFSLLIFSFTKNVMVMGIDALAL-GFFRFIITPTSSTAVAVIGGKERSGSVTGFANFFWQSSGIVGSIIAPL 343
Cdd:cd17355 278 LAASYALRALGLALLLLLPFPPLALLLFAALfGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGL 357
|
330 340
....*....|....*....|....
gi 850525840 344 LINLF-TYTYLWTFVSVLSFLSLI 366
Cdd:cd17355 358 LYDRTgSYTAAWALAVALGLIAAL 381
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
235-368 |
2.07e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 39.75 E-value: 2.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 235 GIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSFTKNVMVMGIDALALGFFRFIITPTSSTAVAVIG 314
Cdd:COG2270 277 IVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLI 356
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 850525840 315 GKERSGSVTGFanffWQSSGIVGSIIAPLLINLFTYtylWTFVSVLSFLSLIFY 368
Cdd:COG2270 357 PPGREAEFFGL----YALSGKAASFLGPLLFGLVTQ---LTGSQRLGILSLIVF 403
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
4-177 |
2.89e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.52 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 4 KRVIFLSASSFFLSYFSRVAWSIVAPLF--TLKTTTTEDSIIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVT 81
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAkeVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 82 SFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFY 161
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
170
....*....|....*.
gi 850525840 162 FISVFSIILGILALVF 177
Cdd:cd06173 368 LAGALLLLAALLLLLL 383
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
16-307 |
3.78e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 39.24 E-value: 3.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 16 LSYFSRVAWSIVAPLFTLKTTTTEDS--IIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITV 93
Cdd:cd17343 14 LYYFNRKSFSFVLPSLMNELGLDKSDlgLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 94 EYLASFLMGFSAGWIYPITVKLLSTSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLALTFSWEFSFYFISVFSIILGIL 173
Cdd:cd17343 94 FSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 174 ALVFL-------------------PSLKLSKSIIKFKDVIRDKNSIYISIGGFLFYL-----TYWVLVLYLYKYLlgvvR 229
Cdd:cd17343 174 CLLFIknepsdvglnnieeeeskgKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGvktavTDWGQLFLIQDKG----Q 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 850525840 230 NEYVAGIIYSLTALTGIFSTILAGYIIKSLGVKRTFLLFISLYSFSLLIFSFtknvmvmgIDALALGFFRFIITPTSS 307
Cdd:cd17343 250 SALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVFMA--------GLTVSLHLFRVHITSDSS 319
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
45-177 |
4.55e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 38.84 E-value: 4.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 45 ALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVSATFPLITVEYLASFLMGFSAGWIYPITVKLLSTSFDDKD 124
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 850525840 125 LPIAMSIYSIAWPLSIVasgiVIPFLA-LTFSWEFSFYFISVFSIILGILALVF 177
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLV----LLPLVAyFIPDWRWLQLAVSLPTFLFFLLSWFV 263
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
42-368 |
6.10e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 38.57 E-value: 6.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 42 IIFALFFLGYILIQIPSGTLADRISANRLLFLSLLGVAVTSFVS--ATFPLITVEYLASFLMGFSAGWIYPITVKLLSTS 119
Cdd:TIGR00894 80 LILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIpwAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 120 FDDKDLPIAMSIYSIAWPLSIVASGIVIPFLA-LTFSWEFSFYFISVFSIILGILALVFL---PSLKLSKSI-------- 187
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPaddPSIHPCISKfekkyins 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 188 ------------IKFKDVIRDKNSIYISIGGFLFYLTYWVLVLYLYKYLLGVVR-NEYVAGIIYSLTALTGIFSTILAGY 254
Cdd:TIGR00894 240 slqgqkgstrqsLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRvSGKENGLLSSLPYLFAWLCSIFAGY 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 255 IIKSLGVKRTFL------LFISLYSFSLLIFSFTknVMVMGIDALALGFFRFIITPTSS--TAVAVIGGKERSGSVTGFA 326
Cdd:TIGR00894 320 LADFLKSSKTLSltaarkIFNGIGGLGPGIFAYA--LPYLSAAFYLTIIILTLANAVSSgpLAGVLINSLDLAPRFLGFI 397
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 850525840 327 NFFWQSSGIVGSIIAPLLINLFTYT---YLWTFVSVLS----FLSLIFY 368
Cdd:TIGR00894 398 KGITGLPGFIGGLIASTLAGNILSQdskNVWLIVFLIMafvnILCVIFY 446
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
41-378 |
8.23e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 38.37 E-value: 8.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 41 SIIFALFFLGYILIQIPSGTLADRISANRLLFLS-LLGVAVTSFVSATFPL--ITVEYLASFLMGFSAGWIYPITVKLLS 117
Cdd:PRK08633 50 AIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVkLFEVGLTLLIVLAYYLgwFWLAFAVTFLLGAQSAIYSPAKYGIIP 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 118 TSFDDKDLPIAMSIYSIAWPLSIVASGIVIPFLA------LTFSWEFSFYFISVFSIILGILALVFL----------PSL 181
Cdd:PRK08633 130 ELVGKENLSRANGLLEAFTIVAILAGTALFSFLFesvngnTPSEILGRIAPAGLVLLAVAVLGLIFAyrlpkvpaaaPEV 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 182 KLSKSIIKFKD------VIRDKNSIYISIGG---FLFYLTYWVLVLYLYKYLLGVVRNEYVAGIIYSLTALTGIFSTILA 252
Cdd:PRK08633 210 FDKKKYLFPKLlwrnlkLLRSDRVLWLAIIGlsyFWFISQLAQANFPAYAKEVLGLDNTFQVQYLLAASAIGIGIGSLLA 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850525840 253 GYIIKS---LGVKRTFLLFISLysfSLLIFSFTKNVMVMGIDALALGFFR-FIITPTSSTaVAVIGGKERSGSVTGFANF 328
Cdd:PRK08633 290 GRLSGRhieLGLVPLGALGLAL---SLFLLPTAPSLASVLVLFFLFGFSAgLFIVPLNAL-IQFRAPEKELGKVLAANNF 365
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 850525840 329 FwQSSGIVGSIIAPLLINLFTYTYLWTFVSVLSFLSLIFYYKLKFMRDYL 378
Cdd:PRK08633 366 L-QNVGMLLFLALTTLFSGLGLSPAGLFYLIALVTLIGTLYTLLLLPDSL 414
|
|
| |
