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Conserved domains on  [gi|850299526|ref|WP_048006158|]
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class I SAM-dependent methyltransferase [Rossellomorea marisflavi]

Protein Classification

class I SAM-dependent DNA methyltransferase( domain architecture ID 11471966)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047
PubMed:  23180741|12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
3-144 5.21e-33

Predicted methyltransferase, contains TPR repeat [General function prediction only];


:

Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 118.18  E-value: 5.21e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526   3 YEGFAYIYD-HLMEDVPYDGWVDFVQAHGERYG-NGGKRVLDIACGTGEISLKLIESGYEVTGVDLSSDMLmvarEKADR 80
Cdd:COG4976   11 FDQYADSYDaALVEDLGYEAPALLAEELLARLPpGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEML----AKARE 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 850299526  81 RGVALPLFNQDMAALDGL-GSYDVVtIFCDSLNYLeteESVKNTFKSVHAHLEQDGVFLFDVHSL 144
Cdd:COG4976   87 KGVYDRLLVADLADLAEPdGRFDLI-VAADVLTYL---GDLAAVFAGVARALKPGGLFIFSVEDA 147
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
3-144 5.21e-33

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 118.18  E-value: 5.21e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526   3 YEGFAYIYD-HLMEDVPYDGWVDFVQAHGERYG-NGGKRVLDIACGTGEISLKLIESGYEVTGVDLSSDMLmvarEKADR 80
Cdd:COG4976   11 FDQYADSYDaALVEDLGYEAPALLAEELLARLPpGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEML----AKARE 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 850299526  81 RGVALPLFNQDMAALDGL-GSYDVVtIFCDSLNYLeteESVKNTFKSVHAHLEQDGVFLFDVHSL 144
Cdd:COG4976   87 KGVYDRLLVADLADLAEPdGRFDLI-VAADVLTYL---GDLAAVFAGVARALKPGGLFIFSVEDA 147
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 40-135 2.84e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 84.92  E-value: 2.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526   40 VLDIACGTGEISLKLIES-GYEVTGVDLSSDMLMVAREKADRRGVALPLFNQDMAALDGL-GSYDVVTIFCdSLNYLETE 117
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPdGSFDLVVSSG-VLHHLPDP 79

                          90
                  ....*....|....*...
gi 850299526  118 EsVKNTFKSVHAHLEQDG 135
Cdd:pfam13649  80 D-LEAALREIARVLKPGG 96
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 37-106 3.57e-12

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 64.02  E-value: 3.57e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 850299526  37 GKRVLDIACGTGEISLKLIESGY---EVTGVDLSSDMLMVAREKADRRGVALPLfnqDMAALDGL------GSYDVVTI 106
Cdd:PRK00216  52 GDKVLDLACGTGDLAIALAKAVGktgEVVGLDFSEGMLAVGREKLRDLGLSGNV---EFVQGDAEalpfpdNSFDAVTI 127
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 39-141 1.26e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 59.75  E-value: 1.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526  39 RVLDIACGTGEISLKLIES-GYEVTGVDLSSDMLMVAREKADRRGVA-LPLFNQDMAAL--DGLGSYDVVtIFCDSLNYL 114
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADnVEVLKGDAEELppEADESFDVI-ISDPPLHHL 79

                         90       100
                 ....*....|....*....|....*..
gi 850299526 115 etEESVKNTFKSVHAHLEQDGVFLFDV 141
Cdd:cd02440   80 --VEDLARFLEEARRLLKPGGVLVLTL 104
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
38-107 2.16e-05

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 44.33  E-value: 2.16e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 850299526    38 KRVLDIACGTGE--ISLKLIESGYEVTGVDLSSDMLMVAREKADRRGVAL--PLFNQDMAALDGLGSYDVVTIF 107
Cdd:smart00828   1 KRVLDFGCGYGSdlIDLAERHPHLQLHGYTISPEQAEVGRERIRALGLQGriRIFYRDSAKDPFPDTYDLVFGF 74
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 38-139 7.57e-04

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 39.58  E-value: 7.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526   38 KRVLDIACGTGEISLKLIESG--YEVTGVDLSSDMLMVAREKADRRGVALPlfnQDMAALD-GLGSYDVvtIFCDS-LNY 113
Cdd:TIGR02072  36 ASVLDIGCGTGYLTRALLKRFpqAEFIALDISAGMLAQAKTKLSENVQFIC---GDAEKLPlEDSSFDL--IVSNLaLQW 110

                          90       100
                  ....*....|....*....|....*.
gi 850299526  114 LeteESVKNTFKSVHAHLEQDGVFLF 139
Cdd:TIGR02072 111 C---DDLSQALSELARVLKPGGLLAF 133
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
3-144 5.21e-33

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 118.18  E-value: 5.21e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526   3 YEGFAYIYD-HLMEDVPYDGWVDFVQAHGERYG-NGGKRVLDIACGTGEISLKLIESGYEVTGVDLSSDMLmvarEKADR 80
Cdd:COG4976   11 FDQYADSYDaALVEDLGYEAPALLAEELLARLPpGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEML----AKARE 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 850299526  81 RGVALPLFNQDMAALDGL-GSYDVVtIFCDSLNYLeteESVKNTFKSVHAHLEQDGVFLFDVHSL 144
Cdd:COG4976   87 KGVYDRLLVADLADLAEPdGRFDLI-VAADVLTYL---GDLAAVFAGVARALKPGGLFIFSVEDA 147
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 14-141 4.65e-25

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 95.85  E-value: 4.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526  14 MEDV-PYDGWVDFVQAHGERYGNGGKRVLDIACGTGEISLKLIESGYEVTGVDLSSDMLMVAREKADRRGVAlpLFNQDM 92
Cdd:COG2227    1 MSDPdARDFWDRRLAALLARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNVD--FVQGDL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 850299526  93 AALD-GLGSYDVVtIFCDSLNYLETEESVkntFKSVHAHLEQDGVFLFDV 141
Cdd:COG2227   79 EDLPlEDGSFDLV-ICSEVLEHLPDPAAL---LRELARLLKPGGLLLLST 124
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 19-157 1.28e-21

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 87.36  E-value: 1.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526  19 YDGWVDFVQAHGERygnGGKRVLDIACGTGEISLKLIESGYEVTGVDLSSDMLMVAREKADRRGVALPLFNQDMAALD-G 97
Cdd:COG2226    8 YDGREALLAALGLR---PGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDLPfP 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 850299526  98 LGSYDVVTIFCdSLNYLETEESVkntFKSVHAHLEQDGVFL---FDVHSLFKMDEIFMDSSFT 157
Cdd:COG2226   85 DGSFDLVISSF-VLHHLPDPERA---LAEIARVLKPGGRLVvvdFSPPDLAELEELLAEAGFE 143
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 40-135 2.84e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 84.92  E-value: 2.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526   40 VLDIACGTGEISLKLIES-GYEVTGVDLSSDMLMVAREKADRRGVALPLFNQDMAALDGL-GSYDVVTIFCdSLNYLETE 117
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPdGSFDLVVSSG-VLHHLPDP 79

                          90
                  ....*....|....*...
gi 850299526  118 EsVKNTFKSVHAHLEQDG 135
Cdd:pfam13649  80 D-LEAALREIARVLKPGG 96
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
36-141 3.77e-18

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 76.79  E-value: 3.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526  36 GGKRVLDIACGTGEISLKLIE--SGYEVTGVDLSSDMLMVAREKADRrgvaLPLFNQDMAALDGLGSYDVVtIFCDSLNY 113
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAErfPGARVTGVDLSPEMLARARARLPN----VRFVVADLRDLDPPEPFDLV-VSNAALHW 75

                         90       100
                 ....*....|....*....|....*...
gi 850299526 114 LETEESVkntFKSVHAHLEQDGVFLFDV 141
Cdd:COG4106   76 LPDHAAL---LARLAAALAPGGVLAVQV 100
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 35-144 5.59e-17

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 76.49  E-value: 5.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526  35 NGGKRVLDIACGTGEISLKLIES-GYEVTGVDLSSDMLMVAREKADRRGVA-LPLFNQDMAALDGL--GSYDVVtIFCDS 110
Cdd:COG0500   25 PKGGRVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALARARAAKAGLGnVEFLVADLAELDPLpaESFDLV-VAFGV 103

                         90       100       110
                 ....*....|....*....|....*....|....
gi 850299526 111 LNYLETEESVKnTFKSVHAHLEQDGVFLFDVHSL 144
Cdd:COG0500  104 LHHLPPEEREA-LLRELARALKPGGVLLLSASDA 136
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 37-139 4.96e-16

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 73.04  E-value: 4.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526  37 GKRVLDIACGTGEISLKLIES-GYEVTGVDLSSDMLMVAREKADRRGVALP--LFNQDMAALDGLGSYDVVTifcdSLNY 113
Cdd:COG2230   52 GMRVLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYARERAAEAGLADRveVRLADYRDLPADGQFDAIV----SIGM 127

                         90       100
                 ....*....|....*....|....*...
gi 850299526 114 LE--TEESVKNTFKSVHAHLEQDGVFLF 139
Cdd:COG2230  128 FEhvGPENYPAYFAKVARLLKPGGRLLL 155
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 37-106 3.57e-12

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 64.02  E-value: 3.57e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 850299526  37 GKRVLDIACGTGEISLKLIESGY---EVTGVDLSSDMLMVAREKADRRGVALPLfnqDMAALDGL------GSYDVVTI 106
Cdd:PRK00216  52 GDKVLDLACGTGDLAIALAKAVGktgEVVGLDFSEGMLAVGREKLRDLGLSGNV---EFVQGDAEalpfpdNSFDAVTI 127
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 41-139 3.64e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 60.76  E-value: 3.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526   41 LDIACGTGEISLKLIESGYEVTGVDLSSDMLMVAREKADRRGVALPLFN-QDMAALDglGSYDVVTifcdSLNYLETEES 119
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTFVVGDaEDLPFPD--NSFDLVL----SSEVLHHVED 74

                          90       100
                  ....*....|....*....|
gi 850299526  120 VKNTFKSVHAHLEQDGVFLF 139
Cdd:pfam08241  75 PERALREIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 39-141 1.26e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 59.75  E-value: 1.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526  39 RVLDIACGTGEISLKLIES-GYEVTGVDLSSDMLMVAREKADRRGVA-LPLFNQDMAAL--DGLGSYDVVtIFCDSLNYL 114
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADnVEVLKGDAEELppEADESFDVI-ISDPPLHHL 79

                         90       100
                 ....*....|....*....|....*..
gi 850299526 115 etEESVKNTFKSVHAHLEQDGVFLFDV 141
Cdd:cd02440   80 --VEDLARFLEEARRLLKPGGVLVLTL 104
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 37-153 1.37e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 60.90  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526   37 GKRVLDIACGTGEISLKLIESGYEVTGVDLSSDMLMVAREKADRRGVAlplfnqDMAALDGLGSYDVVTIFcdslnylET 116
Cdd:pfam13489  23 PGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQFD------EQEAAVPAGKFDVIVAR-------EV 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 850299526  117 EESVKN---TFKSVHAHLEQDGVFLFDVHSL-FKMDEIFMD 153
Cdd:pfam13489  90 LEHVPDppaLLRQIAALLKPGGLLLLSTPLAsDEADRLLLE 130
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 41-137 1.44e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 59.30  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526   41 LDIACGTGEISLKLIES--GYEVTGVDLSSDMLMVAREKADRRG---VALPLFNQDMAALDGLGSYDVVTIfCDSLNYLE 115
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAARERLAALGllnAVRVELFQLDLGELDPGSFDVVVA-SNVLHHLA 79

                          90       100
                  ....*....|....*....|..
gi 850299526  116 TeesVKNTFKSVHAHLEQDGVF 137
Cdd:pfam08242  80 D---PRAVLRNIRRLLKPGGVL 98
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 37-111 8.59e-11

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 59.85  E-value: 8.59e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 850299526  37 GKRVLDIACGTGEISLKLIESGYEVTGVDLSSDMLMVAREKADRRGVA--LPLFNQDMAALdgLGSYDVVTIFcDSL 111
Cdd:PRK07580  64 GLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARERAPEAGLAgnITFEVGDLESL--LGRFDTVVCL-DVL 137
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 35-156 5.61e-10

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 56.27  E-value: 5.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526   35 NGGKRVLDIACGTGEISLKLIE---SGYEVTGVDLSSDMLMVAREKADRRGVA-LPLFNQDMAALDGL---GSYDVVTIF 107
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEelgPNAEVVGIDISEEAIEKARENAQKLGFDnVEFEQGDIEELPELledDKFDVVISN 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 850299526  108 CdSLNYLETEESVKNTFKSVhahLEQDGVFL-FDVHSLFKMDEIFMDSSF 156
Cdd:pfam13847  82 C-VLNHIPDPDKVLQEILRV---LKPGGRLIiSDPDSLAELPAHVKEDST 127
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
37-104 5.87e-09

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 54.52  E-value: 5.87e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 850299526  37 GKRVLDIACGTGEISL-KLIESGYEVTGVDLSSDMLMVAREKADRRGVALPLFNQDMAALDGLGSYDVV 104
Cdd:COG2263   46 GKTVLDLGCGTGMLAIgAALLGAKKVVGVDIDPEALEIARENAERLGVRVDFIRADVTRIPLGGSVDTV 114
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 34-104 4.63e-08

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 52.46  E-value: 4.63e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 850299526  34 GNGGKRVLDIACGTGEI--SLKLIESGYEVTGVDLSSDMLMVAREKADRRGVALP--LFNQDM-AALDGLGSYDVV 104
Cdd:COG2890  110 AGAPPRVLDLGTGSGAIalALAKERPDARVTAVDISPDALAVARRNAERLGLEDRvrFLQGDLfEPLPGDGRFDLI 185
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 37-170 5.82e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 48.02  E-value: 5.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526  37 GKRVLDIACGTGEIslkLIE---SGYEVTGVDLSSDMLMVAREKADRRGVALP-LFNQDMAALDGL-GSYDVvtIFCD-- 109
Cdd:COG1041   27 GDTVLDPFCGTGTI---LIEaglLGRRVIGSDIDPKMVEGARENLEHYGYEDAdVIRGDARDLPLAdESVDA--IVTDpp 101

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 850299526 110 -----SLNYLETEESVKNTFKSVHAHLEQDG--VFLFDVhslfKMDEIFMDSSFTLTDEEVSYIWESF 170
Cdd:COG1041  102 ygrssKISGEELLELYEKALEEAARVLKPGGrvVIVTPR----DIDELLEEAGFKVLERHEQRVHKSL 165
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
10-106 1.44e-06

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 47.82  E-value: 1.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526   10 YDhLMEDV----PYDGWVDFVqahgERYGNG--GKRVLDIACGTGEISLKL---IESGYEVTGVDLSSDMLMVAREKADR 80
Cdd:pfam01209  15 YD-LMNDVisfgIHRLWKDFT----MKCMGVkrGNKFLDVAGGTGDWTFGLsdsAGSSGKVVGLDINENMLKEGEKKAKE 89

                          90       100
                  ....*....|....*....|....*...
gi 850299526   81 RGVALPLFNQD--MAALDGLGSYDVVTI 106
Cdd:pfam01209  90 EGKYNIEFLQGnaEELPFEDDSFDIVTI 117
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
39-84 7.45e-06

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 45.72  E-value: 7.45e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 850299526  39 RVLDIACGTGEISLKLIESGYEVTGVDLSSDMLMVAREKADRRGVA 84
Cdd:PRK11036  47 RVLDAGGGEGQTAIKLAELGHQVILCDLSAEMIQRAKQAAEAKGVS 92
PLN02585 PLN02585
magnesium protoporphyrin IX methyltransferase
 37-105 1.50e-05

magnesium protoporphyrin IX methyltransferase


Pssm-ID: 215319 [Multi-domain]  Cd Length: 315  Bit Score: 45.23  E-value: 1.50e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 850299526  37 GKRVLDIACGTGEISLKLIESGYEVTGVDLSSDMLMVAREKADRRGVALPLFN------QDMAALDglGSYDVVT 105
Cdd:PLN02585 145 GVTVCDAGCGTGSLAIPLALEGAIVSASDISAAMVAEAERRAKEALAALPPEVlpkfeaNDLESLS--GKYDTVT 217
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
38-107 2.16e-05

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 44.33  E-value: 2.16e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 850299526    38 KRVLDIACGTGE--ISLKLIESGYEVTGVDLSSDMLMVAREKADRRGVAL--PLFNQDMAALDGLGSYDVVTIF 107
Cdd:smart00828   1 KRVLDFGCGYGSdlIDLAERHPHLQLHGYTISPEQAEVGRERIRALGLQGriRIFYRDSAKDPFPDTYDLVFGF 74
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 36-104 2.93e-05

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 44.40  E-value: 2.93e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 850299526  36 GGKRVLDIACGTGEISLKLIESGYEVTGVDLSSDMLMVAREKADRRG------VALPLFnQDMAALDGLGSYDVV 104
Cdd:COG2265  233 GGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGlknvefVAGDLE-EVLPELLWGGRPDVV 306
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 40-87 3.68e-05

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 43.98  E-value: 3.68e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 850299526  40 VLDIACGTGEISLKLIESGYEVTGVDLSSDMLMVAREK--ADRRGV----ALPL 87
Cdd:PRK10258  46 VLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQARQKdaADHYLAgdieSLPL 99
PRK14967 PRK14967
putative methyltransferase; Provisional
 37-105 3.91e-05

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 43.50  E-value: 3.91e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526  37 GKRVLDIACGTGEISLKLIESG-YEVTGVDLSSDMLMVAREKADRRGVALPLFNQDMAALDGLGSYDVVT 105
Cdd:PRK14967  37 GRRVLDLCTGSGALAVAAAAAGaGSVTAVDISRRAVRSARLNALLAGVDVDVRRGDWARAVEFRPFDVVV 106
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
31-104 6.28e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 43.22  E-value: 6.28e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 850299526  31 ERYGNGGKRVLDIACGTGeI----SLKLiesGY-EVTGVDLSSDMLMVAREKADRRGVALPLFnqdmaALDGLGSYDVV 104
Cdd:PRK00517 114 EKLVLPGKTVLDVGCGSG-IlaiaAAKL---GAkKVLAVDIDPQAVEAARENAELNGVELNVY-----LPQGDLKADVI 183
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 37-104 6.38e-05

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 42.95  E-value: 6.38e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 850299526  37 GKRVLDIACGTGEISLKLIESG-YEVTGVDLSSDMLMVAREKADRRGVALPLFNQDMAALDGLGSYDVV 104
Cdd:COG3897   71 GKRVLELGCGLGLVGIAAAKAGaADVTATDYDPEALAALRLNAALNGVAITTRLGDWRDPPAAGGFDLI 139
PRK08317 PRK08317
hypothetical protein; Provisional
 37-115 1.58e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 41.85  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526  37 GKRVLDIACGTG----EISLKLIESGyEVTGVDLSSDMLMVAREkadRRGVALPLFNQDMAALDGL----GSYDVVTIfC 108
Cdd:PRK08317  20 GDRVLDVGCGPGndarELARRVGPEG-RVVGIDRSEAMLALAKE---RAAGLGPNVEFVRGDADGLpfpdGSFDAVRS-D 94


                 ....*..
gi 850299526 109 DSLNYLE 115
Cdd:PRK08317  95 RVLQHLE 101
PRK06202 PRK06202
hypothetical protein; Provisional
 39-105 2.09e-04

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 41.52  E-value: 2.09e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 850299526  39 RVLDIACGTGEISLKLI----ESGY--EVTGVDLSSDMLMVAREKADRRGVALPLFNQDmaALDGLGS-YDVVT 105
Cdd:PRK06202  63 TLLDIGCGGGDLAIDLArwarRDGLrlEVTAIDPDPRAVAFARANPRRPGVTFRQAVSD--ELVAEGErFDVVT 134
PRK14968 PRK14968
putative methyltransferase; Provisional
 37-118 2.70e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 40.65  E-value: 2.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526  37 GKRVLDIACGTGEISLKLIESGYEVTGVDLSSDMLMVAREKADRRGVA---LPLFNQDMaaLDGL--GSYDVVtIFcdsl 111
Cdd:PRK14968  24 GDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRnngVEVIRSDL--FEPFrgDKFDVI-LF---- 96


                 ....*....
gi 850299526 112 N--YLETEE 118
Cdd:PRK14968  97 NppYLPTEE 105
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 35-105 4.94e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 40.13  E-value: 4.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526  35 NGGKRVLDIACGTGEISL----KLIESgyEVTGVDLSSDMLMVAREKADRRGVA--LPLFNQD---MAALDGLGSYDVVT 105
Cdd:COG4123   36 KKGGRVLDLGTGTGVIALmlaqRSPGA--RITGVEIQPEAAELARRNVALNGLEdrITVIHGDlkeFAAELPPGSFDLVV 113
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
37-109 6.48e-04

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 40.32  E-value: 6.48e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 850299526  37 GKRVLDIACGTGEIS---LKLIESGYEVTGVDLSSDMLMVAREKADRRGVALPLFNQDMAALDGLGSYDVVtiFCD 109
Cdd:COG0827  116 GLRILDPAVGTGNLLttvLNQLKKKVNAYGVEVDDLLIRLAAVLANLQGHPVELFHQDALQPLLIDPVDVV--ISD 189
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 38-139 7.57e-04

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 39.58  E-value: 7.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850299526   38 KRVLDIACGTGEISLKLIESG--YEVTGVDLSSDMLMVAREKADRRGVALPlfnQDMAALD-GLGSYDVvtIFCDS-LNY 113
Cdd:TIGR02072  36 ASVLDIGCGTGYLTRALLKRFpqAEFIALDISAGMLAQAKTKLSENVQFIC---GDAEKLPlEDSSFDL--IVSNLaLQW 110

                          90       100
                  ....*....|....*....|....*.
gi 850299526  114 LeteESVKNTFKSVHAHLEQDGVFLF 139
Cdd:TIGR02072 111 C---DDLSQALSELARVLKPGGLLAF 133
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 34-82 8.83e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 39.76  E-value: 8.83e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 850299526  34 GNGGKRVLDIACGTGEI--SLKLIESGYEVTGVDLSSDMLMVAREKADRRG 82
Cdd:PRK09328 106 LKEPLRVLDLGTGSGAIalALAKERPDAEVTAVDISPEALAVARRNAKHGL 156
PRK12335 PRK12335
tellurite resistance protein TehB; Provisional
 39-109 9.94e-04

tellurite resistance protein TehB; Provisional


Pssm-ID: 183450 [Multi-domain]  Cd Length: 287  Bit Score: 39.54  E-value: 9.94e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 850299526  39 RVLDIACGTGEISLKLIESGYEVTGVDLSSDMLMVAREKADRRGVALPLFNQDM--AALDglGSYD-----VVTIFCD 109
Cdd:PRK12335 123 KALDLGCGQGRNSLYLALLGFDVTAVDINQQSLENLQEIAEKENLNIRTGLYDInsASIQ--EEYDfilstVVLMFLN 198
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 31-104 8.59e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 36.86  E-value: 8.59e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 850299526   31 ERYGNGGKRVLDIACGTGEIS---LKLIESgyEVTGVDLSSDMLMVAREKADRRGVALPLfnQDMAALDGL-GSYDVV 104
Cdd:pfam06325 156 ERLVKPGESVLDVGCGSGILAiaaLKLGAK--KVVGVDIDPVAVRAAKENAELNGVEARL--EVYLPGDLPkEKADVV 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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