|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
5-486 |
0e+00 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 1001.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 5 LRHILPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNQITVEMPENLNQQSPT 84
Cdd:PRK10815 3 LRHFFPLSLRVRFLLATAAVVLALSLAYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKLSIELPENLDLNSPT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 85 LALIYNEKGKLLWAQRDIPWLVKSIRPEWLKTNGFHEIEADLNTTSSLIHEDRSLQQKLNEIRADNAETEMTHSVAINLY 164
Cdd:PRK10815 83 LVLIYDENGKLLWRQRDVPWLEKMIQPEWLKKNGFHEIETDVNDSSLLLSGDHSAQQQLKEVREDDDDAEMTHSVAVNVY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 165 PATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLNPETT 244
Cdd:PRK10815 163 PATSRLPKLTIVVVDTIPQELQRSYMVWSWFSYVLLANLLLVIPLLWLAAWWSLRPIEALAKQVRELEEGEREQLDPNPP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 245 RELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSMRSSK-LSVDDAEPVMLEQISRISQQIGYYLH 323
Cdd:PRK10815 243 RELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVLQSTLRSLRSGKqMSVEQAEPIMLEQISRISQQIGYYLH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 324 RASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSA 403
Cdd:PRK10815 323 RASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISA 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 404 RQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVILGRQQPT 483
Cdd:PRK10815 403 RQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGRQHST 482
|
...
gi 835756733 484 LND 486
Cdd:PRK10815 483 PKD 485
|
|
| PhoQ_Sensor |
pfam08918 |
PhoQ Sensor; The PhoQ Sensor is required for the virulence of various Gram-negative bacteria ... |
10-189 |
4.56e-105 |
|
PhoQ Sensor; The PhoQ Sensor is required for the virulence of various Gram-negative bacteria by allowing interaction of PhoPQ with the intracellular membrane, resulting in remodelling of the bacterial cell surface and subsequent bacterial resistance to host antimicrobial peptides. The domain contains a major flat acidic surface, which binds to at least 3 calcium ions, neutralising the domain's negative charge and allowing interaction with the negatively charged membrane. This domain recognizes divalent metal cations, and antimicrobial cationic peptides (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 430316 Cd Length: 179 Bit Score: 310.82 E-value: 4.56e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 10 PLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNQITVEMPENLNQQSPTLALIY 89
Cdd:pfam08918 1 PFSLRTRFLLATAAVVLALSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYSLAQWDDNKLTIAVPPNLDLNSPTLVLIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 90 NEKGKLLWAQRDIPWLVKSIRPEWLKTNGFHEIEADLNTTSSLIHEDRSLQQKLNEIRADNAeTEMTHSVAINLYPATLN 169
Cdd:pfam08918 81 DENGKLLWRQRHVPELEKHIKPEWLKKNGFYELDTDTDTSSALLGNNPLAQDQLKAINDDDD-NELTHSVAVNRYPATSR 159
|
170 180
....*....|....*....|
gi 835756733 170 MPQLTIVVIDTIPVELKRSY 189
Cdd:pfam08918 160 LPALTIVVVDTIPQELQRSD 179
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-477 |
4.70e-79 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 242.54 E-value: 4.70e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 343 PLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSARQTETELHIIVEDDGPGIP 422
Cdd:cd16954 1 PLLDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVP 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 835756733 423 SNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIL 477
Cdd:cd16954 81 ESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
159-477 |
1.21e-38 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 143.12 E-value: 1.21e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 159 VAINLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREK 238
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 239 LNPETTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSMRSSkLSVDDAEPV--MLEQISRISQ 316
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE-LDEEQREYLetILRSADRLLR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 317 QIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACKYC 395
Cdd:COG0642 160 LINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVrGDPDRLRQVLLNLLSNAIKYT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 396 LE--FVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLRPGQGV--GLAVAREIVDQYDGKIETSESLLGGA 471
Cdd:COG0642 240 PEggTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTglGLAIVKRIVELHGGTIEVESEPGKGT 319
|
....*.
gi 835756733 472 RMEVIL 477
Cdd:COG0642 320 TFTVTL 325
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
250-477 |
3.43e-38 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 139.27 E-value: 3.43e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 250 LVRNLNRLLKSERERydkyRTTLTDLTHSLKTPLAVMQSTLRSMRSSKLSVDDAEPVMLEQIS----RISQQIGYYLHRA 325
Cdd:COG2205 2 LEEALEELEELERLK----SEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIResaeRLLRLIEDLLDLS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 326 SMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPE-ISFVGEKNDFMEVMGNLLDNACKYCLE--FVEVS 402
Cdd:COG2205 78 RLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPggTITIS 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 835756733 403 ARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIL 477
Cdd:COG2205 158 ARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
160-477 |
4.97e-34 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 131.98 E-value: 4.97e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 160 AINLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKL 239
Cdd:COG5002 53 ALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 240 NPETTRELTSLVRNLNRLLK---SERERYDKYRTTLT-DLTHSLKTPLAVMQSTLRSMRSSKLSVDDAEP----VMLEQI 311
Cdd:COG5002 133 RLSLRLSALLLGLLLLAAVErdiTELERLEQMRREFVaNVSHELRTPLTSIRGYLELLLDGAADDPEERReyleIILEEA 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 312 SRISQQIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDN 390
Cdd:COG5002 213 ERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVlGDPDRLEQVLTNLLDN 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 391 ACKYCLE--FVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLR----PGQGVGLAVAREIVDQYDGKIETS 464
Cdd:COG5002 293 AIKYTPEggTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRsretGGTGLGLAIVKHIVEAHGGRIWVE 372
|
330
....*....|...
gi 835756733 465 ESLLGGARMEVIL 477
Cdd:COG5002 373 SEPGKGTTFTITL 385
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
375-477 |
5.79e-25 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 98.88 E-value: 5.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 375 GEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRAD---TLRPGQGVGLAV 449
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsRKIGGTGLGLSI 80
|
90 100
....*....|....*....|....*...
gi 835756733 450 AREIVDQYDGKIETSESLLGGARMEVIL 477
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITL 108
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
380-477 |
6.22e-24 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 95.75 E-value: 6.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 380 FMEVMGNLLDNACKYCLEF--VEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVD 455
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGgtIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSRegGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 835756733 456 QYDGKIETSESLLGGARMEVIL 477
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
193-477 |
7.06e-21 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 95.08 E-value: 7.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 193 SWFIYVLAAnlLLVIPLLWVAAWWSLRPIESLakevreLEEHHREKLNPETTR-------ELTSLVRNLNRLL----KSE 261
Cdd:PRK10549 166 SWLIVALST--LLAALATFLLARGLLAPVKRL------VEGTHKLAAGDFTTRvtptsrdELGRLAQDFNQLAstleKNE 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 262 RERydkyRTTLTDLTHSLKTPLAVMQSTLRSMRssklsvDDAEPVMLEQISRISQQIGYY------LHRASMRSGSALLS 335
Cdd:PRK10549 238 QMR----RDFMADISHELRTPLAVLRGELEAIQ------DGVRKFTPESVASLQAEVGTLtklvddLHQLSLSDEGALAY 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 336 RELH-PVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTETELHI 412
Cdd:PRK10549 308 RKTPvDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSggSLHISAEQRDKTLRL 387
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 835756733 413 IVEDDGPGIPSNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIL 477
Cdd:PRK10549 388 TFADSAPGVSDEQLQKLFERFYRTEGSRNrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 456
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
236-482 |
9.49e-21 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 95.87 E-value: 9.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 236 REKLNPETTREL---TSLVRN-LNRL----------LKSERERYdkyRTTL-TDLTHSLKTPLAVMqstlrsmrssklsV 300
Cdd:PRK10490 620 RQLMIPEQQRLLetfTLLIANaLERLtltaseeqarLASEREQL---RNALlAALSHDLRTPLTVL-------------F 683
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 301 DDAEPVML----------EQISRISQQI-------GYYLHRASMRSGSALLSRELHPvaplLDNLT-SALNKV-YQRKGV 361
Cdd:PRK10490 684 GQAEILTLdlasegsphaRQASEIRQQVlnttrlvNNLLDMARIQSGGFNLRKEWLT----LEEVVgSALQMLePGLSGH 759
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 362 NISLDISPEISFVGEKNDFME-VMGNLLDNACKYCLEFVE--VSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRAD- 437
Cdd:PRK10490 760 PINLSLPEPLTLIHVDGPLFErVLINLLENAVKYAGAQAEigIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNk 839
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 835756733 438 -TLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVILGRQQP 482
Cdd:PRK10490 840 eSAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLETP 885
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
375-477 |
4.29e-20 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 85.50 E-value: 4.29e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 375 GEKNDFMEVMGNLLDNACKYCLEFVEVSAR-QTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLR-PGQGVGLAVARE 452
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTlSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGgGGTGLGLSIVRK 80
|
90 100
....*....|....*....|....*
gi 835756733 453 IVDQYDGKIETSESLLGGARMEVIL 477
Cdd:pfam02518 81 LVELLGGTITVESEPGGGTTVTLTL 105
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
203-477 |
4.71e-20 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 92.60 E-value: 4.71e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 203 LLLVIPLLWVAA--WWSLRPIESLAKEVRELEEHHREKLNPETTRELTSLVRNLNRLlkseRERYD------KYRTTLTd 274
Cdd:PRK11100 190 LLLGIALLIGAGvvWWLNRSIRRLTRYADAVTEGKPVPLPKLGSSELRELAQALESM----RVKLEgkayveQYVQTLT- 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 275 ltHSLKTPLAVMQSTLRSMRSSkLSVDDAEPVM---LEQISRISQQIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSA 351
Cdd:PRK11100 265 --HELKSPLAAIRGAAELLQED-PPPEDRARFTgniLTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEA 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 352 LNKVYQRKGVNISLDIsPEISFVGEKNDFMEVMGNLLDNAckycLEF------VEVSARQTETELHIIVEDDGPGIPSNK 425
Cdd:PRK11100 342 REAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNA----IDFspeggtITLSAEVDGEQVALSVEDQGPGIPDYA 416
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 835756733 426 RDVVFDRG---QRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIL 477
Cdd:PRK11100 417 LPRIFERFyslPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
343-477 |
8.16e-20 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 91.06 E-value: 8.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 343 PLLDNLTSALNKVYQRKGVNISLDISPEISFVGEK-NDFMEVMGNLLDNACKYCLE------FVEVSARQTETELHIIVE 415
Cdd:COG3290 244 PVLAALLLGKAARARERGIDLTIDIDSDLPDLPLSdTDLVTILGNLLDNAIEAVEKlpeeerRVELSIRDDGDELVIEVE 323
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 835756733 416 DDGPGIPSNKRDVVFDRGQRadT-LRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIL 477
Cdd:COG3290 324 DSGPGIPEELLEKIFERGFS--TkLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
200-477 |
1.06e-19 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 91.18 E-value: 1.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 200 AANLLLVIPLLWV--AAWWSLRPIESLAKEVRE-LEEHHREKLNPETTRELTSLVR--------------NLNRLLKSER 262
Cdd:COG5000 118 AAERLLGIPLEELigKPLEELLPELDLAELLREaLERGWQEEIELTRDGRRTLLVRasplrddgyvivfdDITELLRAER 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 263 erydkyRTTLTD----LTHSLKTPLAVMQSTLRSMRS--SKLSVDDAEP------VMLEQISRISQQIGYYLHRASMRSg 330
Cdd:COG5000 198 ------LAAWGElarrIAHEIKNPLTPIQLSAERLRRklADKLEEDREDleraldTIIRQVDRLKRIVDEFLDFARLPE- 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 331 salLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTE 407
Cdd:COG5000 271 ---PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVlADRDQLEQVLINLLKNAIEAIEEggEIEVSTRRED 347
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 835756733 408 TELHIIVEDDGPGIPSNKRDVVFDrgqradtlrP-------GQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIL 477
Cdd:COG5000 348 GRVRIEVSDNGPGIPEEVLERIFE---------PffttkpkGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
384-477 |
4.70e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 82.37 E-value: 4.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 384 MGNLLDNACKYCLEFVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLR----PGQGVGLAVAREIVDQYDG 459
Cdd:cd16949 5 LENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARdresGGTGLGLAIAERAIEQHGG 84
|
90
....*....|....*...
gi 835756733 460 KIETSESLLGGARMEVIL 477
Cdd:cd16949 85 KIKASNRKPGGLRVRIWL 102
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
1-482 |
3.36e-18 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 87.15 E-value: 3.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 1 MRRILRHILPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNQITVEMPENLNQ 80
Cdd:COG4251 22 LLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 81 QSPTLALIYNEKGKLLWAQRDIPWLVKSIRPEWLKTNGFHEIEADLNTTSSLIHEDRSLQQKLNEIRADNAETEMTHSVA 160
Cdd:COG4251 102 LLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 161 INLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLN 240
Cdd:COG4251 182 LLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLEL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 241 PETTRELTSLVRNLNRllkSERErydkyrttLTDLTHS----LKTPLAVMQS---TLRSMRSSKLSvDDAepvmLEQISR 313
Cdd:COG4251 262 EELEEELEERTAELER---SNEE--------LEQFAYVashdLREPLRKISGfsqLLEEDYGDKLD-EEG----REYLER 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 314 ISQQIgyylHRASM---------RSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEIsfVGEKNDFMEVM 384
Cdd:COG4251 326 IRDAA----ERMQAliddllaysRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTV--RGDPTLLRQVF 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 385 GNLLDNACKYCLE----FVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQR--ADTLRPGQGVGLAVAREIVDQYD 458
Cdd:COG4251 400 QNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRlhSRDEYEGTGIGLAIVKKIVERHG 479
|
490 500
....*....|....*....|....*
gi 835756733 459 GKIeTSESLLG-GARMEVILGRQQP 482
Cdd:COG4251 480 GRI-WVESEPGeGATFYFTLPKAPA 503
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-472 |
1.09e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 78.24 E-value: 1.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 383 VMGNLLDNACKYCLEFVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLR----PGQGVGLAVAREIVDQYD 458
Cdd:cd16939 4 ALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRdratGGFGLGLAIVHRVALWHG 83
|
90
....*....|....
gi 835756733 459 GKIETSESLLGGAR 472
Cdd:cd16939 84 GHVECDDSELGGAC 97
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
199-477 |
1.79e-17 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 84.60 E-value: 1.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 199 LAANLLLVIPLLWVAAWwslrpieSLAKEVRELEEHHRE------KLNPET---TRELTSLVRNLNRLLKSERERYDKYR 269
Cdd:PRK09470 172 LLVTMLVSTPLLLWLAW-------SLAKPARKLKNAADEvaqgnlRQHPELetgPQEFRQAGASFNQMVTALERMMTSQQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 270 TTLTDLTHSLKTPLAVMQSTLRSMR-----SSKLSVDDAEpvmleqISRISQQIGYYLHRASMRSGSALlSRELHPVAPL 344
Cdd:PRK09470 245 RLLSDISHELRTPLTRLQLATALLRrrqgeSKELERIETE------AQRLDSMINDLLVLSRNQQKNHL-ERETFKANSL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 345 LDN-LTSALNKVYQRkgvNISLDIS--PEISFV-GEKNDFMEVMGNLLDNACKYCLEFVEVSARQTETELHIIVEDDGPG 420
Cdd:PRK09470 318 WSEvLEDAKFEAEQM---GKSLTVSapPGPWPInGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPG 394
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 835756733 421 IPSNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIL 477
Cdd:PRK09470 395 VPEEEREQIFRPFYRVDEARDresgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWL 455
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
253-472 |
1.67e-15 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 78.49 E-value: 1.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 253 NLNRLLKSererydkyRTTLTD-LTHSLKTPLAVMQSTLrSMrSSKLSvdDAEPVMLEQ-ISRISQQIGYYLHRASmrsg 330
Cdd:PRK10604 204 NINALIAS--------KKQLIDgIAHELRTPLVRLRYRL-EM-SDNLS--AAESQALNRdIGQLEALIEELLTYAR---- 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 331 salLSR---ELHPVAPLLDN-LTSALNKVYQ-RKGVNISLDISPEISFVGEKNDFME-VMGNLLDNACKYCLEFVEVSAR 404
Cdd:PRK10604 268 ---LDRpqnELHLSEPDLPAwLSTHLADIQAvTPEKTVRLDTPHQGDYGALDMRLMErVLDNLLNNALRYAHSRVRVSLL 344
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 835756733 405 QTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDGKIETSESLLGGAR 472
Cdd:PRK10604 345 LDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDratgGCGLGLAIVHSIALAMGGSVNCDESELGGAR 416
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
196-477 |
1.69e-15 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 77.92 E-value: 1.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 196 IYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLNPETTRELTSLVRNLNRLLKSERERydkyRTTLTDL 275
Cdd:COG4191 58 LLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEEL----RELQEQL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 276 THS----------------LKTPLAVMQSTLRSMRSSKLSVDDAEPV------MLEQISRISQQIgyylhrASMRSGSAL 333
Cdd:COG4191 134 VQSeklaalgelaagiaheINNPLAAILGNAELLRRRLEDEPDPEELrealerILEGAERAAEIV------RSLRAFSRR 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 334 LSRELHPV--APLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACkYCLE-----FVEVSARQ 405
Cdd:COG4191 208 DEEEREPVdlNELIDEALELLRPRLKARGIEVELDLPPDLPPVlGDPGQLEQVLLNLLINAI-DAMEegeggRITISTRR 286
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 835756733 406 TETELHIIVEDDGPGIPSNKRDVVFD-------RGQradtlrpGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIL 477
Cdd:COG4191 287 EGDYVVISVRDNGPGIPPEVLERIFEpffttkpVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
380-477 |
1.90e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 72.11 E-value: 1.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 380 FMEVMGNLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLRP----GQGVGLAVAREI 453
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrasgGSGLGLAICHNI 84
|
90 100
....*....|....*....|....
gi 835756733 454 VDQYDGKIETSESLLGGARMEVIL 477
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTL 108
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-477 |
6.35e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 70.39 E-value: 6.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 383 VMGNLLDNACKYCLEF------VEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRG--QRADTLRpgqGVGLAVAREIV 454
Cdd:cd16915 4 IVGNLIDNALDALAATgapnkqVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGvsTKGQGER---GIGLALVRQSV 80
|
90 100
....*....|....*....|...
gi 835756733 455 DQYDGKIETSESLLGGARMEVIL 477
Cdd:cd16915 81 ERLGGSITVESEPGGGTTFSIRI 103
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
204-477 |
1.05e-14 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 76.10 E-value: 1.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 204 LLVIPLLWVA-AWWSLR----PIESL---AKEVRELEehHREKLNPETTRELTSLVRNLNRLLKSERERYDKyRTTLT-D 274
Cdd:PRK09467 159 TLAIGLLSVAgGWLFIRiqnrPLVALehaALQVGKGE--IPPPLREYGASEVRSVTRAFNQMAAGIKQLEDD-RTLLMaG 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 275 LTHSLKTPLavmqsTLRSMRSSKLSVDDAepVMLEQISR--------ISQQIGYylhrasMRSGSALlSRELHPVAPLLD 346
Cdd:PRK09467 236 VSHDLRTPL-----TRIRLATEMMSEEDG--YLAESINKdieecnaiIEQFIDY------LRTGQEM-PMEMADLNALLG 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 347 NLTSALNKvYQRKgvnISLDISPeisfvGEKNDFME------VMGNLLDNACKYCLEFVEVSARQTETELHIIVEDDGPG 420
Cdd:PRK09467 302 EVIAAESG-YERE---IETALQP-----GPIEVPMNpiaikrALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPG 372
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 835756733 421 IPSNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIL 477
Cdd:PRK09467 373 IPPEQLKHLFQPFTRGDSARgsSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWL 431
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
113-477 |
1.59e-14 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 75.44 E-value: 1.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 113 WLKTNGFHEIEADLNTTSSLIHEDRSLQQKLNEIRADNAETEMTHSVAINLYPATLNMPQLTIVVIDTIPVELKRSYMVW 192
Cdd:COG2972 77 LALLLILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLR 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 193 SWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLNPETTRELTSLVRNLNRLLkserERYDKYRTTL 272
Cdd:COG2972 157 RLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSGNDEIGILARSFNEMV----ERIKELIEEV 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 273 TDLTHSLK-TPLAVMQS---------TLRSMRSSKLSVDDaepvmlEQISRISQQIGYYLhRASMRSGSAL--LSRELHP 340
Cdd:COG2972 233 YELELEKKeAELKALQAqinphflfnTLNSIRWLAELEDP------EEAEEMLEALSKLL-RYSLSKGDELvtLEEELEL 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 341 VAPLLdnltsALNKVYQRKGVNISLDISPEIsfvgekndfMEVM------GNLLDNACKYCLE------FVEVSARQTET 408
Cdd:COG2972 306 IKSYL-----EIQKLRFGDRLEVEIEIDEEL---------LDLLipklilQPLVENAIEHGIEpkegggTIRISIRKEGD 371
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 835756733 409 ELHIIVEDDGPGIPSNKRDVVFdrgQRADTLRPGQGVGLAVAREIVDQYDGK---IETSESLLGGARMEVIL 477
Cdd:COG2972 372 RLVITVEDNGVGMPEEKLEKLL---EELSSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRI 440
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-474 |
5.70e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 67.86 E-value: 5.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 383 VMGNLLDNACKYCLEFVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYDGK 460
Cdd:cd16950 4 VLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARgtSGTGLGLAIVQRISDAHGGS 83
|
90
....*....|....*.
gi 835756733 461 IETSESLLGG--ARME 474
Cdd:cd16950 84 LTLANRAGGGlcARIE 99
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-470 |
4.66e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 62.34 E-value: 4.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 381 MEVMGNLLDNACKYCLEF----VEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLR--PGQGVGLAVAREIV 454
Cdd:cd16921 2 GQVLTNLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREeyEGTGVGLAIVRKII 81
|
90
....*....|....*.
gi 835756733 455 DQYDGKIeTSESLLGG 470
Cdd:cd16921 82 ERHGGRI-WLESEPGE 96
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-475 |
6.07e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 62.42 E-value: 6.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 382 EVMGNLLDNACKYCLEFVEVSARQTETEL-HIIVEDDGPGIPSNKRDVVFDRGQRAD-TLRPGQGVGLAVAREIVDQYDG 459
Cdd:cd16940 16 LLLRNLVDNAVRYSPQGSRVEIKLSADDGaVIRVEDNGPGIDEEELEALFERFYRSDgQNYGGSGLGLSIVKRIVELHGG 95
|
90
....*....|....*.
gi 835756733 460 KIETSESLLGGARMEV 475
Cdd:cd16940 96 QIFLGNAQGGGLEAWV 111
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
228-461 |
1.69e-11 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 65.74 E-value: 1.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 228 VRELEEHHREKlNPETTRELTSLVRNLNRL--LKSERErydkyrtTLTD-----------LTHSLKTPLAVMQSTLRSMR 294
Cdd:PRK09303 106 YSGLGENLQPS-EIDSGRYSQELLQLSDELfvLRQENE-------TLLEqlkfkdrvlamLAHDLRTPLTAASLALETLE 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 295 S-SKLSVDDAEPVMLEQ-----------ISRISQQIgyyLHRASMRSgSALlsrELHPV----APLLDNLTSALNKVYQR 358
Cdd:PRK09303 178 LgQIDEDTELKPALIEQlqdqarrqleeIERLITDL---LEVGRTRW-EAL---RFNPQkldlGSLCQEVILELEKRWLA 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 359 KGVNISLDISPEISFVGEKNDFM-EVMGNLLDNACKYCLEFVEVSArqteTELH-------IIVEDDGPGIPSNKRDVVF 430
Cdd:PRK09303 251 KSLEIQTDIPSDLPSVYADQERIrQVLLNLLDNAIKYTPEGGTITL----SMLHrttqkvqVSICDTGPGIPEEEQERIF 326
|
250 260 270
....*....|....*....|....*....|....
gi 835756733 431 D---RGQRADTlRPGQGVGLAVAREIVDQYDGKI 461
Cdd:PRK09303 327 EdrvRLPRDEG-TEGYGIGLSVCRRIVRVHYGQI 359
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
199-460 |
5.63e-11 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 63.83 E-value: 5.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 199 LAANLLLVIPLLWVAAW---WSLRPIESLAKEvreLEEHHREKLNP----ETTRELTSLVRNLNRLLKSERERYDKYRTT 271
Cdd:PRK10755 64 LVPSLVMVSLTLLICFQavrWITRPLAELQKE---LEARTADNLTPiaihSSTLEIEAVTSALNQLVSRLTSTLDQERLF 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 272 LTDLTHSLKTPLAVMQSTLRSMrsSKLSVDDAEPvMLEQISRISQQIGYYLHRAsmRSGSALLSRELHPVApLLDN---- 347
Cdd:PRK10755 141 TADVAHELRTPLAGIRLHLELL--EKQHHIDVAP-LIARLDQMMHTVEQLLQLA--RAGQSFSSGHYQTVK-LLEDvilp 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 348 LTSALNKVYQRKGVNISLDISP-EISFVGEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPSN 424
Cdd:PRK10755 215 SQDELSEMLEQRQQTLLLPESAaDITVQGDATLLRLLLRNLVENAHRYSPEgsTITIKLSQEDGGAVLAVEDEGPGIDES 294
|
250 260 270
....*....|....*....|....*....|....*.
gi 835756733 425 KRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGK 460
Cdd:PRK10755 295 KCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQ 330
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
219-484 |
9.69e-11 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 64.16 E-value: 9.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 219 RPIESLAKEVRELEeHHREKLNPET---TRELTSLVRNlNRLLKSERERYDKYRTT-LTDLTHSLKTPLAVMQSTLRSMR 294
Cdd:PRK11466 393 RLMDAFRSNVHALN-RHREQLAAQVkarTAELQELVIE-HRQARAEAEKASQAKSAfLAAMSHEIRTPLYGILGTAQLLA 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 295 SSKLS---------VDDAEPVMLEQISRIsqqigyyLHRASMRSGSALLSRELHPVAP--LLDNLTSALNKVYQRKGVNI 363
Cdd:PRK11466 471 DNPALnaqrddlraITDSGESLLTILNDI-------LDYSAIEAGGKNVSVSDEPFEPrpLLESTLQLMSGRVKGRPIRL 543
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 364 SLDISPEI--SFVGEKNDFMEVMGNLLDNACKYCLE-FVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLR 440
Cdd:PRK11466 544 ATDIADDLptALMGDPRRIRQVITNLLSNALRFTDEgSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR 623
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 835756733 441 PGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVILGRQQPTL 484
Cdd:PRK11466 624 GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVATA 667
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
150-479 |
1.18e-10 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 63.64 E-value: 1.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 150 NAETEMTHS----VAINLYPATLNMPQLTIVVIDTIPV------ELKRSYMVWSWFIYvlaanlLLVIPLLWVAAWWSLR 219
Cdd:PRK09835 138 HGHGHMEHSnwrmIALPVGPLVDGKPIYTLLIALSIDFhlhyinDLKNKLIMTASVIS------LLIVFIVLLAVHKGHA 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 220 PIESLAKEVREL-EEHHREKLNPETTR-ELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLA--VMQS--TLRSM 293
Cdd:PRK09835 212 PIRSVSRQIQNItSKDLDVRLDPQTVPiELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITnlITQTeiALSQS 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 294 RSSKlsvdDAEPVM---LEQISRISQQIGYYLHRASMRSgsallsRELHPVAPLLDnLTSALNKVY-------QRKGVNI 363
Cdd:PRK09835 292 RSQK----ELEDVLysnLEELTRMAKMVSDMLFLAQADN------NQLIPEKKMLD-LADEVGKVFdffeawaEERGVEL 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 364 SLDISPeISFVGEKNDFMEVMGNLLDNACKYCL--EFVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLR- 440
Cdd:PRK09835 361 RFVGDP-CQVAGDPLMLRRAISNLLSNALRYTPagEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRq 439
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 835756733 441 ---PGQGVGLAVAREIVDQYDGKIETsESLLGGARMEVILGR 479
Cdd:PRK09835 440 rkgEGSGIGLAIVKSIVVAHKGTVAV-TSDARGTRFVISLPR 480
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
233-477 |
3.08e-10 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 61.95 E-value: 3.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 233 EHHRE-KLNPETTRELTSLVRNLNRLLKSERERydkyRTTLTDLTHSLKTPLAVMQSTLRSMRSSKLS---VDDAEPVML 308
Cdd:PRK11006 172 GRHLEiRVMPYTEGQLLMVARDVTQMHQLEGAR----RNFFANVSHELRTPLTVLQGYLEMMQDQPLEgalREKALHTMR 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 309 EQISRISQQIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGvNISLDISPEISFVGEKNDFMEVMGNLL 388
Cdd:PRK11006 248 EQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLEREAQTLSQGKH-TITFEVDNSLKVFGNEDQLRSAISNLV 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 389 DNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDGKIE 462
Cdd:PRK11006 327 YNAVNHTPEgtHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSrqtgGSGLGLAIVKHALSHHDSRLE 406
|
250
....*....|....*
gi 835756733 463 TSESLLGGARMEVIL 477
Cdd:PRK11006 407 IESEVGKGTRFSFVL 421
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-477 |
1.30e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 55.66 E-value: 1.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 382 EVMGNLLDNACKYCLEF---VEVSARQTETELHIIVEDDGPGIPSNKRDVVFDR--GQRADTLRPGQ--GVGLAVAREIV 454
Cdd:cd16953 3 QVLRNLIGNAISFSPPDtgrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRfyTERPANEAFGQhsGLGLSISRQII 82
|
90 100
....*....|....*....|....*..
gi 835756733 455 DQYDGKI----ETSESLLGGARMEVIL 477
Cdd:cd16953 83 EAHGGISvaenHNQPGQVIGARFTVQL 109
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
362-469 |
1.92e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 59.93 E-value: 1.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 362 NISLDIS-----PEISFVGEKNDFMEVMGNLLDNAckycLEFV--------EVSARQTETELHIIVEDDGPGIPSNKRDV 428
Cdd:PRK11086 411 GITLIISedsqlPDSGDEDQVHELITILGNLIENA----LEAVggeeggeiSVSLHYRNGWLHCEVSDDGPGIAPDEIDA 486
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 835756733 429 VFDRGqrADTLRPGQGVGLAVAREIVDQYDGKIETsESLLG 469
Cdd:PRK11086 487 IFDKG--YSTKGSNRGVGLYLVKQSVENLGGSIAV-ESEPG 524
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-461 |
2.03e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 55.60 E-value: 2.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 383 VMGNLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQ 456
Cdd:cd16947 24 ILKNLISNAIKYGSDgkFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNsakqGNGLGLTITKRLAES 103
|
....*
gi 835756733 457 YDGKI 461
Cdd:cd16947 104 MGGSI 108
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
383-465 |
2.63e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 54.81 E-value: 2.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 383 VMGNLLDNACKYCLE---FVEVSARQTETE---LHIIVEDDGPGIPSNKRDVVFDRGQRAD--TLRP--GQGVGLAVARE 452
Cdd:cd16922 4 ILLNLLGNAIKFTEEgevTLRVSLEEEEEDgvqLRFSVEDTGIGIPEEQQARLFEPFSQADssTTRKygGTGLGLAISKK 83
|
90
....*....|....
gi 835756733 453 IVDQYDGKIE-TSE 465
Cdd:cd16922 84 LVELMGGDISvESE 97
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
199-453 |
2.79e-09 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 59.28 E-value: 2.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 199 LAANLLLVIPLLWVAaWWSLRPIESLAKEVRELEEHHREKLNpeTTR---ELTSLVRNLNRLLKS-----ERERydkyRT 270
Cdd:PRK10337 168 LVALPIMLIILMVLL-GRELAPLKKLALALRMRDPDSETPLN--ATGvpsEVRPLVEALNQLFARthammVRER----RF 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 271 TlTDLTHSLKTPLAVM--QSTLrsmrsSKLSVDDaePVMLEQ--------ISRISQQIGYYLHRASMRSGSALlsRELHP 340
Cdd:PRK10337 241 T-SDAAHELRSPLAALkvQTEV-----AQLSDDD--PQARKKallqlhagIDRATRLVDQLLTLSRLDSLDNL--QDVAE 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 341 VaPLLDNLTSALNKVY---QRKGVNISLDI-SPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSARQTETELHiiVED 416
Cdd:PRK10337 311 I-PLEDLLQSAVMDIYhtaQQAGIDVRLTLnAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFT--VRD 387
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 835756733 417 DGPGIPSNKRDVVFDR-----GQRAdtlrPGQGVGLAVAREI 453
Cdd:PRK10337 388 NGPGVTPEALARIGERfyrppGQEA----TGSGLGLSIVRRI 425
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-477 |
3.42e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 54.35 E-value: 3.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 382 EVMGNLLDNACKYCLEFVEVSAR--QTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDG 459
Cdd:cd16943 6 QVLLNLLVNAAQAMEGRGRITIRtwAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQKHGG 85
|
90
....*....|....*...
gi 835756733 460 KIETSESLLGGARMEVIL 477
Cdd:cd16943 86 TIRVASVPGGGTRFTIIL 103
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
384-462 |
3.65e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 54.00 E-value: 3.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 384 MGNLLDNACKYCLEF--VEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRG---QRADTLRPGQGVGLAVAREIVDQYD 458
Cdd:cd16945 9 INNLLDNAIDFSPEGglIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFyslPRPHSGQKSTGLGLAFVQEVAQLHG 88
|
....
gi 835756733 459 GKIE 462
Cdd:cd16945 89 GRIT 92
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
383-477 |
4.97e-09 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 54.04 E-value: 4.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 383 VMGNLLDNACKYCLEFVEVSARQTETELH---IIVEDDGPGIPSNKRDVVFDRGQRADTL----RPGQGVGLAVAREIVD 455
Cdd:cd16925 8 VVLNLLSNAFKFTPDGGRIRCILEKFRLNrflLTVSDSGPGIPPNLREEIFERFRQGDGSstraHGGTGLGLSIVKEFVE 87
|
90 100
....*....|....*....|..
gi 835756733 456 QYDGKIETSESLLGGARMEVIL 477
Cdd:cd16925 88 LHGGTVTVSDAPGGGALFQVEL 109
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
347-462 |
1.13e-08 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 56.78 E-value: 1.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 347 NLTSALNKVYQ------RKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACK------------YCLEFVEVSARQTE 407
Cdd:COG3852 205 NLHEVLERVLEllraeaPKNIRIVRDYDPSLPEVlGDPDQLIQVLLNLVRNAAEampeggtitirtRVERQVTLGGLRPR 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 408 TELHIIVEDDGPGIPSNKRDVVFD-----RGQradtlrpGQGVGLAVAREIVDQYDGKIE 462
Cdd:COG3852 285 LYVRIEVIDNGPGIPEEILDRIFEpffttKEK-------GTGLGLAIVQKIVEQHGGTIE 337
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-462 |
1.67e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 52.00 E-value: 1.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 383 VMGNLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYD 458
Cdd:cd16923 4 VFSNLLSNAIKYSPEntRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRntEGAGLGLSIAKAIIELHG 83
|
....
gi 835756733 459 GKIE 462
Cdd:cd16923 84 GSAS 87
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-464 |
2.75e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 52.58 E-value: 2.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 357 QRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLE------FVEVSARQTETELHIIVE---------DDGPGI 421
Cdd:cd16935 14 REKGIEFTIEIDIPILLPISPLDLCIIFGNLLDNAIEACAKidkenrFIHLKIRQKKGFLIISIEnsyegelkkKNGLFL 93
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 835756733 422 pSNKRDvvfdrgqradtlrPGQGVGLAVAREIVDQYDGKIETS 464
Cdd:cd16935 94 -STKKD-------------KNHGIGLKSIREIVKKYNGNLSIE 122
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
355-477 |
3.44e-08 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 55.74 E-value: 3.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 355 VYQRKGVNISLDISPEISFVGEKNDFME-VMGNLLDNACKYCLEFVEVSAR---QTETELHIIVEDDGPGIPSNKRDVVF 430
Cdd:PRK11360 475 AGVQARVDFETELDNELPPIWADPELLKqVLLNILINAVQAISARGKIRIRtwqYSDGQVAVSIEDNGCGIDPELLKKIF 554
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 835756733 431 DRgqrADTLRP-GQGVGLAVAREIVDQYDGKIETsESLLG-GARMEVIL 477
Cdd:PRK11360 555 DP---FFTTKAkGTGLGLALSQRIINAHGGDIEV-ESEPGvGTTFTLYL 599
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
277-462 |
7.81e-08 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 54.74 E-value: 7.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 277 HSLKTPLAVMQSTLRSMRSSKLSVDDAEPVMLEQISRISQQIGYYLHRASMRSGS---ALLSRELHPVAPLLdnLTSALN 353
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQPGIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNkekENINELIQDVVTLL--ETEAIL 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 354 KvyqrkGVNISLDISPEISFV-GEKNDFMEVMGNLLDNAckycLE------FVEVSARQTETELHIIVEDDGPGIPSNkr 426
Cdd:COG5805 374 H-----NIQIRLELLDEDPFIyCDENQIKQVFINLIKNA----IEampnggTITIHTEEEDNSVIIRVIDEGIGIPEE-- 442
|
170 180 190
....*....|....*....|....*....|....*...
gi 835756733 427 dvVFDR-GQRADTLR-PGQGVGLAVAREIVDQYDGKIE 462
Cdd:COG5805 443 --RLKKlGEPFFTTKeKGTGLGLMVSYKIIENHNGTID 478
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
386-472 |
1.62e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 49.51 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 386 NLLDNACKYCLEFVEVSAR--QTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDG 459
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRwsQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCrntgGTGLGLAIVKHVMSRHDA 86
|
90
....*....|...
gi 835756733 460 KIETSESLLGGAR 472
Cdd:cd16952 87 RLLIASELGKGSR 99
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-477 |
4.02e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 48.30 E-value: 4.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 382 EVMGNLLDNACKYCLEF--------VEVSARQtETELHIIVEDDGPGIPSNKRDVVFDrgQRADTLRPGQGVGLAVAREI 453
Cdd:cd16944 7 QVLTNILKNAAEAIEGRpsdvgevrIRVEADQ-DGRIVLIVCDNGKGFPREMRHRATE--PYVTTRPKGTGLGLAIVKKI 83
|
90 100
....*....|....*....|....
gi 835756733 454 VDQYDGKIETSESLLGGARMEVIL 477
Cdd:cd16944 84 MEEHGGRISLSNREAGGACIRIIL 107
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
410-462 |
5.88e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 47.78 E-value: 5.88e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 835756733 410 LHIIVEDDGPGIPSNKRDVVFDR--GQRADtlrpGQGVGLAVAREIVDQYDGKIE 462
Cdd:cd16918 44 LRVSVIDNGPGIPPDLQDTIFYPmvSGREN----GTGLGLAIAQNIVSQHGGVIE 94
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
412-462 |
1.07e-06 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 50.46 E-value: 1.07e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 835756733 412 IIVEDDGPGIPSNKRDVVFD---RGQRAdtlrpGQGVGLAVAREIVDQYDGKIE 462
Cdd:PRK11073 283 IDIEDNGPGIPPHLQDTLFYpmvSGREG-----GTGLGLSIARNLIDQHSGKIE 331
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
378-464 |
1.10e-06 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 46.82 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 378 NDFMEVMGNLLDNA---CKYCLE--FVEVSARQTETELHIIVE-------DDGPGIPSNKRDvvfdrgqradtlRPGQGV 445
Cdd:pfam14501 4 VDLCVIFGNLLDNAieaCSKIDDnrFIRLKIREKQNFLIIRIEntyegelKFEGKLPSTKTK------------GDGHGI 71
|
90
....*....|....*....
gi 835756733 446 GLAVAREIVDQYDGKIETS 464
Cdd:pfam14501 72 GLKSIRRIVKKYGGNLSTE 90
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-477 |
1.24e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 46.68 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 382 EVMGNLLDNACKYCLEF----VEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQY 457
Cdd:cd16976 3 QVLMNLLQNALDAMGKVenprIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVEEH 82
|
90 100
....*....|....*....|
gi 835756733 458 DGKIETSESLLGGARMEVIL 477
Cdd:cd16976 83 GGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
402-477 |
2.59e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 45.85 E-value: 2.59e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 835756733 402 SARQTETELHIIVEDDGPGIPSNKRDVVFDrgQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIL 477
Cdd:cd16920 30 TSPADDRAVTISVKDTGPGIAEEVAGQLFD--PFYTTKSEGLGMGLSICRSIIEAHGGRLSVESPAGGGATFQFTL 103
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
190-477 |
1.55e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 46.54 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 190 MVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREklnpetTREltslvrnlnrllkSERER----- 264
Cdd:COG4585 1 LLALALLGALALLVGALLGLLLALVLLRARRAERAAELERELAARAEE------ARE-------------EERRRiarel 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 265 YDkyrttltDLTHSLktplAVMQSTLRSMRSSKLSVDDAEPVMLEQISRISQQIGyylhrASMRSgsalLSRELHPVAPL 344
Cdd:COG4585 62 HD-------GVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREAL-----AELRR----LVRGLRPPALD 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 345 LDNLTSAL----NKVYQRKGVNISLDISPEISFVGekndfMEVMGNL-------LDNACKYCL-EFVEVSARQTETELHI 412
Cdd:COG4585 122 DLGLAAALeelaERLLRAAGIRVELDVDGDPDRLP-----PEVELALyrivqeaLTNALKHAGaTRVTVTLEVDDGELTL 196
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 835756733 413 IVEDDGPGIPSNKrdvvfdrgqradtlRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIL 477
Cdd:COG4585 197 TVRDDGVGFDPEA--------------APGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
1-477 |
2.56e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 46.82 E-value: 2.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 1 MRRILRHILPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNQITVEMPENLNQ 80
Cdd:COG3920 14 AALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 81 QSPTLALIYNEKGKLLWAQRDIPWLVKSIRPEWLKTNGFHEIEADLNTTSSLIHEDRSLQQKLNEIRADNAETEMTHSVA 160
Cdd:COG3920 94 AAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 161 INLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLN 240
Cdd:COG3920 174 AAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 241 PETTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSL--------------KTPLAVMQSTLRsMRSSKLSVDDAEPV 306
Cdd:COG3920 254 LLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLeekelllrelhhrvKNNLQVVSSLLR-LQARRADDPEAREA 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 307 MLEQISRIsqqigyylhrASMrsgsALLSRELH--------PVAPLLDNLTSALNKVYQRKGVNISLDIsPEISF----- 373
Cdd:COG3920 333 LEESQNRI----------QAL----ALVHELLYqsedwegvDLRDYLRELLEPLRDSYGGRGIRIELDG-PDVELpadaa 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 374 ------VGEkndfmevmgnLLDNACKYCLE-----FVEVSARQTETELHIIVEDDGPGIPSNkrdvvFDRGQRadtlrpg 442
Cdd:COG3920 398 vplgliLNE----------LVTNALKHAFLsgeggRIRVSWRREDGRLRLTVSDNGVGLPED-----VDPPAR------- 455
|
490 500 510
....*....|....*....|....*....|....*
gi 835756733 443 QGVGLAVAREIVDQYDGKIETSESllGGARMEVIL 477
Cdd:COG3920 456 KGLGLRLIRALVRQLGGTLELDRP--EGTRVRITF 488
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
199-477 |
2.82e-05 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 46.94 E-value: 2.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 199 LAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLNPETTR-ELTSLVRNLNRLLKSERERYD------KYRTT 271
Cdd:PRK15347 303 LLILVLLTSVLFLLLRRYLAKPLWRFVDIINKTGPAALEPRLPENRLdELGSIAKAYNQLLDTLNEQYDtlenkvAERTQ 382
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 272 -------------------LTDLTHSLKTPLAVMQSTLRSMRSSKLSVDDAEPV---------MLEQI------SRIsqq 317
Cdd:PRK15347 383 alaeakqraeqankrksehLTTISHEIRTPLNGVLGALELLQNTPLTAEQMDLAdtarqctlsLLAIInnlldfSRI--- 459
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 318 igyylhrasmRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKnDFMEV---MGNLLDNACKy 394
Cdd:PRK15347 460 ----------ESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVPLYLHL-DSLRLrqiLVNLLGNAVK- 527
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 395 cleFVE-----VSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLG 469
Cdd:PRK15347 528 ---FTEtggirLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGV 604
|
....*...
gi 835756733 470 GARMEVIL 477
Cdd:PRK15347 605 GSCFSLVL 612
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
245-462 |
3.96e-05 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 46.12 E-value: 3.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 245 RELTSLVRNLNRLLKSERerYDKYRTTLTDLTHSLKTPLA-------VMQSTLRSMRSSKLSVddaepvMLEQISRISQQ 317
Cdd:COG5809 249 RDITERKKLEELLRKSEK--LSVVGELAAGIAHEIRNPLTslkgfiqLLKDTIDEEQKTYLDI------MLSELDRIESI 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 318 IGYYL-----HRASMRSGSalLSRELHPVAPLLDnlTSALnkvyqRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNA 391
Cdd:COG5809 321 ISEFLvlakpQAIKYEPKD--LNTLIEEVIPLLQ--PQAL-----LKNVQIELELEDDIPDIlGDENQLKQVFINLLKNA 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 392 CKYCLEFVEVSARQTETELHII---VEDDGPGIPSNKRDVVFDrgqradtlrP-------GQGVGLAVAREIVDQYDGKI 461
Cdd:COG5809 392 IEAMPEGGNITIETKAEDDDKVvisVTDEGCGIPEERLKKLGE---------PfyttkekGTGLGLMVSYKIIEEHGGKI 462
|
.
gi 835756733 462 E 462
Cdd:COG5809 463 T 463
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
271-477 |
4.32e-05 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 46.22 E-value: 4.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 271 TLTDLTHSLKTPLAVMQSTLRSMRSS-KLSVDDAEPVMLEQISRISQQIGYYLhrASMRSGSALLSRELHPVaPLLDNLT 349
Cdd:COG4192 436 TMTSLAHELNQPLNAMSMYLFSAKKAlEQENYAQLPTSLDKIEGLIERMDKII--KSLRQFSRKSDTPLQPV-DLRQVIE 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 350 SALNKVYQR-KGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSARQTET--ELHIIVEDDGPGIPSNKR 426
Cdd:COG4192 513 QAWELVESRaKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNaeNLRVAISDNGNGWPLVDK 592
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 835756733 427 dvvfdrgqradTLRP-------GQGVGLAVAREIVDQYDGKIETSESLLGGARmeVIL 477
Cdd:COG4192 593 -----------LFTPftttkevGLGLGLSICRSIMQQFGGDLYLASTLERGAM--VIL 637
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
334-482 |
5.63e-05 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 45.82 E-value: 5.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 334 LSRELHPVAPLLdnltsalnKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTETEL 410
Cdd:PRK13837 522 LSELVTEIAPLL--------RVSLPPGVELDFDQDQEPAVVeGNPAELQQVLMNLCSNAAQAMDGagRVDISLSRAKLRA 593
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 411 H---------------IIVEDDGPGIPSNKRDVVFDRgqrADTLRP-GQGVGLAVAREIVDQYDGKIETSESLLGGARME 474
Cdd:PRK13837 594 PkvlshgvlppgryvlLRVSDTGAGIDEAVLPHIFEP---FFTTRAgGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFD 670
|
....*...
gi 835756733 475 VILGRQQP 482
Cdd:PRK13837 671 VYLPPSSK 678
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
376-461 |
5.69e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 45.59 E-value: 5.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 376 EKNDFMEVMGNLLDNACKYCLE------FVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLRPGQ-GVGLA 448
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEASLRsdegnkIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGEhGIGLY 508
|
90
....*....|...
gi 835756733 449 VAREIVDQYDGKI 461
Cdd:PRK15053 509 LIASYVTRCGGVI 521
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
272-461 |
8.22e-05 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 45.50 E-value: 8.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 272 LTDLTHSLKTPLAVMQSTLRSMRSSKLSVDD-AEPVMLEQISRIS--QQIGYYLHRASMRSGSALLSRELHPVAPLLDNL 348
Cdd:PRK09959 716 LATMSHEIRTPISSIMGFLELLSGSGLSKEQrVEAISLAYATGQSllGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNT 795
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 349 TSALNKVYQRKGVNISLDIS-PEISFVG-EKNDFMEVMGNLLDNACKYClefVEVSARQTETELHI---------IVEDD 417
Cdd:PRK09959 796 CHSFGAIAASKSIALSCSSTfPDHYLVKiDPQAFKQVLSNLLSNALKFT---TEGAVKITTSLGHIddnhavikmTIMDS 872
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 835756733 418 GPGIPSNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYDGKI 461
Cdd:PRK09959 873 GSGLSQEEQQQLFKRYSQTSAGRqqTGSGLGLMICKELIKNMQGDL 918
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
272-330 |
8.34e-05 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 40.66 E-value: 8.34e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 835756733 272 LTDLTHSLKTPLAVMQSTLRSMRSSKLSVDDAE--PVMLEQISRISQQIGYYLHRASMRSG 330
Cdd:pfam00512 6 LANLSHELRTPLTAIRGYLELLRDEKLDEEQREylETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
382-465 |
8.51e-05 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 45.32 E-value: 8.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 382 EVMGNLLDNACKYCLE---FVEVSaRQTETELHIIVEDDGPGIPSNKRDVVFD--------RGQRADTlrpGQGVGLAVA 450
Cdd:PRK11091 401 QILWNLISNAVKFTQQggvTVRVR-YEEGDMLTFEVEDSGIGIPEDELDKIFAmyyqvkdsHGGKPAT---GTGIGLAVS 476
|
90
....*....|....*.
gi 835756733 451 REIVDQYDGKIE-TSE 465
Cdd:PRK11091 477 KRLAQAMGGDITvTSE 492
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
272-330 |
9.59e-05 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 40.24 E-value: 9.59e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 835756733 272 LTDLTHSLKTPLAVMQSTLRSMRSSKLSVDDAE--PVMLEQISRISQQIGYYLHRASMRSG 330
Cdd:smart00388 6 LANLSHELRTPLTAIRGYLELLLDTELSEEQREylETILREAERLLRLINDLLDLSRIEAG 66
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
387-458 |
1.13e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 41.82 E-value: 1.13e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 835756733 387 LLDNACKYCLEF-----VEVSARQTETELHIIVEDDGPGIPSNkrdvvfDRGQRADTLRPGqGVGLAVAREIVDQYD 458
Cdd:COG2172 42 AVTNAVRHAYGGdpdgpVEVELELDPDGLEIEVRDEGPGFDPE------DLPDPYSTLAEG-GRGLFLIRRLMDEVE 111
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
357-465 |
1.89e-04 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 44.01 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 357 QRKGVNISLDISPEISFVGEKNDFM-EVMGNLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDrg 433
Cdd:PRK10364 325 NSREIQLRFTANDTLPEIQADPDRLtQVLLNLYLNAIQAIGQhgVISVTASESGAGVKISVTDSGKGIAADQLEAIFT-- 402
|
90 100 110
....*....|....*....|....*....|...
gi 835756733 434 QRADTLRPGQGVGLAVAREIVDQYDGKIE-TSE 465
Cdd:PRK10364 403 PYFTTKAEGTGLGLAVVHNIVEQHGGTIQvASQ 435
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
386-475 |
2.79e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 40.14 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 386 NLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPSNKRDVVFDRGQRADTLRPGQ---GVGLAVAREIVDQYDGK 460
Cdd:cd16975 11 NIISNACQYAPEggTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGghyGMGLYIAKNLVEKHGGS 90
|
90
....*....|....*
gi 835756733 461 IETSESLLGGARMEV 475
Cdd:cd16975 91 LIIENSQKGGAEVTV 105
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
399-477 |
1.33e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 37.92 E-value: 1.33e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 835756733 399 VEVSARQTETELHIIVEDDGPGIPSNKRdvvfdrgqradtlRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIL 477
Cdd:cd16917 21 VRVTLSYTADELTLTVVDDGVGFDGPAP-------------PGGGGFGLLGMRERAELLGGTLTIGSRPGGGTRVTARL 86
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
359-465 |
4.18e-03 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 39.83 E-value: 4.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 359 KGVNISLDISPEI--SFVGEKNDFMEVMGNLLDNACKycleFVE----------VSARQTETELHIIVEDDGPGIPSNKR 426
Cdd:PRK11107 386 KGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIK----FTEsgnidilvelRALSNTKVQLEVQIRDTGIGISERQQ 461
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 835756733 427 DVVFDRGQRADT----LRPGQGVGLAVAREIVDQYDGKIE-TSE 465
Cdd:PRK11107 462 SQLFQAFRQADAsisrRHGGTGLGLVITQKLVNEMGGDISfHSQ 505
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-462 |
5.69e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 36.49 E-value: 5.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 383 VMGNLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPSnkRDV--VFDRGQRADTLRPGQ---GVGLAVAREIVD 455
Cdd:cd16948 9 IIGQIVSNALKYSKQggKIEIYSETNEQGVVLSIKDFGIGIPE--EDLprVFDKGFTGENGRNFQestGMGLYLVKKLCD 86
|
....*..
gi 835756733 456 QYDGKIE 462
Cdd:cd16948 87 KLGHKID 93
|
|
| NIP100 |
COG5244 |
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ... |
221-378 |
5.86e-03 |
|
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 227569 [Multi-domain] Cd Length: 669 Bit Score: 39.28 E-value: 5.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 221 IESLAKEVREL-EEHHREKLNPE--TTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMqSTLRSMRSSK 297
Cdd:COG5244 88 ESKGMDKDGEIkQENHEDRIHFEesKIRRLEETIEALKSTEKEEIVELRRENEELDKINLSLRERISSE-EPELNKDGSK 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835756733 298 LSVDDAEPVMLE-------------QISRISQQIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRkgvnis 364
Cdd:COG5244 167 LSYDELKEFVEEsrvqvydmvelvsDISETLNRNGSIQRSSVRECERSNIHDVLFLVNGILDGVIDELNGELER------ 240
|
170
....*....|....
gi 835756733 365 ldISPEISFVGEKN 378
Cdd:COG5244 241 --LRRQLVSLMSSH 252
|
|
| |
