|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
27-432 |
3.03e-87 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 270.21 E-value: 3.03e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 27 WRILPILMISYIFAYLDRINVGIAKLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVI 106
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 107 APLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFhnmhgla 186
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF------- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 187 GWKWLFILQGTPSLLvglvvlkllpdrindakwlsadekaimnarvkedavddttveqASLGTVLRNGKLWLLTLIYFCL 266
Cdd:cd17319 155 GWRWAFIIEGLLGLL-------------------------------------------LAVLWWFYLRQVWGLALGYFGI 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 267 IAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKH--RERRWHLAVIAVMSGVGMVISALyADN 344
Cdd:cd17319 192 NYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYL-TTS 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 345 LWIAMFGLTLGAAGGLSTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSDLTHSTLTGMLIISCTLFV 424
Cdd:cd17319 271 PVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALL 350
|
....*...
gi 817691378 425 GAAAIFLI 432
Cdd:cd17319 351 AALLVLLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
35-432 |
4.54e-67 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 219.13 E-value: 4.54e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 35 ISYIFAYLDRINVGIAKLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVIAPLTALVS 114
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 115 TPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFHnmhglagWKWLFIL 194
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFS-------WQWAFII 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 195 QGTPSLLVGLVVLKLLPDRINDAKWLSADEKAIMN--ARVKEDAVDDTTVEQASLGTVLRNGKLWLLTLIYFCLIAGFYT 272
Cdd:TIGR00893 154 EGVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVggLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 273 VSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKHRERRWHLAVIAVMSGV-GMVISAL-----YADNLW 346
Cdd:TIGR00893 234 FLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIaGLVLSLLmfatnYVNIPY 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 347 IAMFGLTLGAAGGLSTlPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSDLTHSTLTGMLIISCTLFVGA 426
Cdd:TIGR00893 314 AALALVALGFFGLGAG-AIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGA 392
|
....*.
gi 817691378 427 AAIFLI 432
Cdd:TIGR00893 393 LSYLLL 398
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-436 |
9.15e-60 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 198.94 E-value: 9.15e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 19 ENAWRRAVWRILPILMISYIFAYLDRINVGIAKLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAA 98
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 99 LLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEH 178
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 179 FhnmhglaGWKWLFILQGTPSLlvglvvlkllpdrindakwlsadekaimnarvkedavddttveqasLGTVLRngkLWL 258
Cdd:COG2271 161 F-------GWRAAFLILGLPGL----------------------------------------------LLALLR---FWL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 259 LTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKH-RERRWHLAVIAVMSGVGMVI 337
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 338 sALYADNLWIAMFGLTLGAAGGLSTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSDLTHSTlTGMLI 417
Cdd:COG2271 265 -LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ-AAFLL 342
|
410
....*....|....*....
gi 817691378 418 ISCTLFVGAAAIFLIPGRV 436
Cdd:COG2271 343 LAALALLAALLALLLLRET 361
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
27-401 |
2.57e-53 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 183.22 E-value: 2.57e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 27 WRILPILMISYIFAYLDRINVGIAKLQ-MSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAV 105
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 106 IAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWImEHFHNMHGL 185
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGV-FKILGVGGL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 186 AGWKWLFILQGTPSLLVGLVVLKLLPDRINDAKWLSADEKAIMNARVKEDAVD--DTTVEQASLGTVLRNGKLWLLTLIY 263
Cdd:cd17327 163 AGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGkgDQKFKWKQIKEAFKDPRTWLLFLFF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 264 FCLIAGFYTVSFWLPTLVrNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKHRERRWHLAVIAVMSGVGmVISALYAD 343
Cdd:cd17327 243 FCSQITNNGISNFLPLIL-KSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVG-SIILLAAP 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 817691378 344 NLWIAMFGLTLGAAGGLSTLPLFWSLPTAFLGG-TMAAVGIALINSIGNLAGFVAPYLM 401
Cdd:cd17327 321 NPPGAYFAAYILGGGSYAGFPILLSWISSNCAGyTKRATVLAIMLIFYNVGNIVAPQIF 379
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-435 |
4.52e-45 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 161.20 E-value: 4.52e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 27 WRILPILMISYIFAYLDRINVGIAKLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVI 106
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 107 APLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFhnmhgla 186
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF------- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 187 GWKWLFILQGTPSLLVGLVVLKLLPDRindakwlsadekaimnarvKEDAVDDTTVEQASLGTVLRNGKLWLLTLIYFCL 266
Cdd:COG2223 157 GWRNAFLILGILLLVVAVLAWLFLRDP-------------------PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 267 IAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKHRERRWHLAVIAVMsGVGMVISALYADNLW 346
Cdd:COG2223 218 FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALM-ALGLLLLALALGSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 347 IAMFG-LTLGAAGGLSTLPLFWSLPTAFlGGTMAAVGIALINSIGNLAGFVAPYLMGILSDLTHSTLTGMLIISCTLFVG 425
Cdd:COG2223 297 LFLVLfLLLGLALGGGNGAVFALVPDIF-PTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVA 375
|
410
....*....|
gi 817691378 426 AAAIFLIPGR 435
Cdd:COG2223 376 LVLTLLLYRR 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
33-431 |
1.14e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 110.21 E-value: 1.14e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 33 LMISYIFAYLDRINVGIAKLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVIAPLTAL 112
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 113 VSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFhnmhgLAGWKWLF 192
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-----GFGWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 193 ILQGTPSLLVGLVVLKLLPDRindakwlsadekaiMNARVKEDAVDDTTVEQASLGTVLRNGKLWLLTLIYFCLIAGFYT 272
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDP--------------PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 273 VSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKHRERRWHLAVIAVMSGVGMVIsALYADNLWIAMFGL 352
Cdd:cd06174 222 FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLAL-LLLAPSLLLLLLLL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 817691378 353 TLGAAGGLSTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSDLTHStLTGMLIISCTLFVGAAAIFL 431
Cdd:cd06174 301 LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG-LTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-397 |
1.06e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 106.98 E-value: 1.06e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 20 NAWRRAVWRILPILMISYIFAYLDRINVGIAKLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAAL 99
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 100 LVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHF 179
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 180 hnmhglaGWKWLFILQGTPSLLVGlvvlkllpdrindakwlsadekAIMNARVKEDAVDDTTVEQASLGTVLRNGKLWLL 259
Cdd:COG2814 162 -------GWRWVFLVNAVLALLAL----------------------LLLLRLLPESRPAARARLRGSLRELLRRPRLLLL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 260 TLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKHReRRWHLAVIAVMSGVGMVISA 339
Cdd:COG2814 213 LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG-RRRLLLIGLLLLALGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 817691378 340 LyADNLWIAMFGLTLGAAGGLSTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVA 397
Cdd:COG2814 292 L-AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
33-398 |
7.12e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 101.73 E-value: 7.12e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 33 LMISYIFAYLDRINVGIA-KLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVIAPLTA 111
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 112 LVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFhnmhglaGWKWL 191
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-------GWRAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 192 FILQGTPSLLVGLVVLKLLPDRindakwlsadekaimnARVKEDAVDDTTVEQASLGTVLRNGKLWLLTLIYFCLIAGFY 271
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRPPP----------------ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 272 TVSFWLPTLVRNAGVkDVFTVGMLTAIPYAAAIFTMIVASRSADK--HRERRWHLAVIAVMSGVGMVISALYADNLWIAM 349
Cdd:pfam07690 218 GLLTYLPLYQEVLGL-SALLAGLLLGLGGLLGAIGRLLLGRLSDRlgRRRRLLLALLLLILAALGLLLLSLTLSSLWLLL 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 817691378 350 FGLTLGAAGGLsTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAP 398
Cdd:pfam07690 297 ALLLLGFGFGL-VFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
41-432 |
5.49e-19 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 88.00 E-value: 5.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 41 YLDRINVGIAKLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVI---APLTALVSTPF 117
Cdd:cd17380 12 YADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLAtllTPLLAYSSLPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 118 qFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFhnmhglaGWKWLFILQGT 197
Cdd:cd17380 92 -LILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYY-------GWPSVFYFFGL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 198 PSLLvglvvlkllpdrindakWLSADEKAIMnarvkedavddttveqaslgtvlrngKLWLLTLIYFCLIAGFYTVSFWL 277
Cdd:cd17380 164 LGLL-----------------WALVWLIYLP--------------------------PVWAIIVAHFCMNWGFYILLSWL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 278 PTLVRNAGVKDVfTVGMLTAIPYAAAIFTMIVASRSADKHRERRWHLA-VIAVMSGVGMVISAL------YADNLWIAMF 350
Cdd:cd17380 201 PTYFHEVLVPLA-KGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTsVRKLMQSIGFLGPALfllllsHTDSFSLALL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 351 GLTLGAAGGLSTLPLFWSLPtAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSDLTHSTLTGMLIISCTLFVGaAAIF 430
Cdd:cd17380 280 CMSVALGLSAFSSSGVLVNH-QDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVG-AVVF 357
|
..
gi 817691378 431 LI 432
Cdd:cd17380 358 LL 359
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
53-432 |
8.77e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 87.62 E-value: 8.77e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 53 QMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESG 132
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 133 FYPGVILYLSFWFPSyRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFhnmhglaGWKWLFILQGTPSLLVGLVVLKLLPD 212
Cdd:COG2807 123 GNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAAL-------GWRGALAVWALLALLALLLWLPLLRR 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 213 RindakwlsadekaimnarvkeDAVDDTTVEQASLGTVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVkDVFTV 292
Cdd:COG2807 195 R---------------------PAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGL-SAATA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 293 GMLTAIPYAAAIFTMIVASRSADKHRERRWHLAVIAVMSGVGMVisALYADNLWIAMFGLTLGAAGGLSTLPLFWSLPTA 372
Cdd:COG2807 253 GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLL--GLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGL 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 817691378 373 FLGGTM-AAVGIALINSIGNLAGFVAPYLMGILSDLTHSTLTGMLIISCTLFVGAAAIFLI 432
Cdd:COG2807 331 RARTPAeAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
89-430 |
6.64e-17 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 81.49 E-value: 6.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 89 KFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLG 168
Cdd:cd17316 62 RIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 169 GPLSGWIMEHFHnmhGLAGWKWLFILQGTPsllvglvvlkllpdrindakwlsadekaimnarvkedavddttveqASLG 248
Cdd:cd17316 142 ALVASLLIPLLS---GDWGWRILFLIGALP----------------------------------------------ALLA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 249 TVLRNGkLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKhRERRWHLAVIA 328
Cdd:cd17316 173 LLLRRR-TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR-IGRKKTLVIGL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 329 VMSGVGMVISALYAD-NLWIAMFGLTLGAAGGLSTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSDL 407
Cdd:cd17316 251 ILSGILALPLFYLLSgSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330
|
330 340
....*....|....*....|...
gi 817691378 408 THSTLTGMLIISCTLFVGAAAIF 430
Cdd:cd17316 331 TGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
80-432 |
5.63e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 79.16 E-value: 5.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 80 QIPSNIILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAA 159
Cdd:cd17325 48 SPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSS 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 160 AVPLSGLLGGPLSGWIMEHFhnmhglaGWKWLFILQGTPSLLVGLVVLKLLPDRindakwlsadekaimnARVKEDAVDD 239
Cdd:cd17325 128 AIGLGFLIGPLLGGLLADAL-------GYRAPFLVCAALALLALVLALLLLPEP----------------RPPPNKRAVS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 240 TTVEQASLGTVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKHRE 319
Cdd:cd17325 185 AARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 320 RRWHLAVIAVMSGVGMVISalYADNLWIAMFGLTL-GAAGGLSTLPLFWSLPTAFLGGTMAAVgIALINSIGNLAGFVAP 398
Cdd:cd17325 265 KPLILIGLLLSAVALLLLP--LATSFWLLLLLLALlGLGLGLVFPATLALLADIVPPEGRGTA-MGLFNTAFSLGMVLGP 341
|
330 340 350
....*....|....*....|....*....|....
gi 817691378 399 YLMGILSDlTHSTLTGMLIISCTLFVGAAAIFLI 432
Cdd:cd17325 342 LLGGFLYD-AFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
35-409 |
8.14e-16 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 78.57 E-value: 8.14e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 35 ISYIFAYLDRINVGIAKLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVIAPLTALVS 114
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 115 TPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSG-WIMEHFhnmhglaGWKWLFI 193
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfGIAELY-------SWHWVFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 194 LQGTPSLLVGLVVLKLLPDRINDAKWLSADEKAIMNARV-KEDAVDDTTVEQASLGTVLRNGKLWLLTLIYFCLIAGFYT 272
Cdd:TIGR00881 155 VPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGdAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 273 VSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKHRERRWHLAVIAVMSGVgMVISALY-----ADNLWI 347
Cdd:TIGR00881 235 ILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALI-IVSLLVYwlnpaANPLMD 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 817691378 348 AMFGLTLGAAGGLSTLpLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSDLTH 409
Cdd:TIGR00881 314 LICLFALGFLVYGPQM-LIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
86-431 |
1.32e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 78.08 E-value: 1.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 86 ILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFML-GLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLS 164
Cdd:cd17355 61 LLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLgGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 165 GLLGGPLSGWIMEHFhnmhglaGWKWLFILQGTPSLLVGLVVLKLLPDRINDAKwlsadekaimnarVKEDAVDDTTVEQ 244
Cdd:cd17355 141 SLVFLPLGAALIEAF-------GWRTALLVLALLALLVLVPVLLLLRRRPADLA-------------LRAYDDASPASPG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 245 ASLGTVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIpYAAAIFTMIVASRSADKHrERRWHL 324
Cdd:cd17355 201 STLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALI-GLFNIVGRLLSGWLGDRY-SPRRLL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 325 AVIAVMSGVGMVI-SALYADNLWIAMFGLTLGAAGGlSTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGI 403
Cdd:cd17355 279 AASYALRALGLALlLLLPFPPLALLLFAALFGLGWG-ATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGL 357
|
330 340
....*....|....*....|....*...
gi 817691378 404 LSDLTHSTlTGMLIISCTLFVGAAAIFL 431
Cdd:cd17355 358 LYDRTGSY-TAAWALAVALGLIAALLVL 384
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
89-404 |
1.91e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 74.70 E-value: 1.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 89 KFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLG 168
Cdd:TIGR00895 78 RIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVG 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 169 GPLSGWIMEHFhnmhglaGWKWLFILQGTPSLLVGLVVLKLLPDRI---------------------NDAKWLSADEKAI 227
Cdd:TIGR00895 158 GFLAGWLIPVF-------GWRSLFYVGGIAPLLLLLLLMRFLPESIdflvskrpetvrrivnaiapqMQAEAQSALPEQK 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 228 MNARVKEDAVDDTTVEQASLGTVLrngkLWLLtliYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIpYAAAIFTM 307
Cdd:TIGR00895 231 STQGTKRSVFKALFQGKTARITVL----LWLL---YFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALF-NFGGVIGS 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 308 IVASRSADKHRERrwHLAVIAVMSGVGMVISALYA---DNLWIAMFGLTLGAAGGLSTLPlfwSLPTAFLGGTMAAVGIA 384
Cdd:TIGR00895 303 IIFGWLADRLGPR--VTALLLLLGAVFAVLVGSTLfspTLLLLLGAIAGFFVNGGQSGLY---ALMALFYPTAIRATGVG 377
|
330 340
....*....|....*....|
gi 817691378 385 LINSIGNLAGFVAPYLMGIL 404
Cdd:TIGR00895 378 WAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
53-431 |
3.54e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 73.74 E-value: 3.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 53 QMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESG 132
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 133 FYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFhnmhglaGWKWLFILQGTPSLLVGLVVLKLLPD 212
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-------GWRAAFLAIAVLALLAALLLWRLLPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 213 RindakwlsadekaimnarvkEDAVDDTTVEQASLGTVLRNGKLWLLTLIYFCLIAGFYTV-SFWLPTLVRNAGVKDVFT 291
Cdd:cd17324 177 L--------------------PPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALyTYLAPFLTDVPGFSSSAI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 292 VGMLtAIPYAAAIFTMIVASRSADKHRERRwhLAVIAVMSGVGMVISALYADNLWIAMFGLTLGAAGGLSTLPLFWSLPT 371
Cdd:cd17324 237 IGLL-LLFGVAGVVGSPLAGRLADRGGRRA--LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 372 AfLGGTMAAVGIALINSIGNLAGFVAPYLMGILsdLTHSTLTGMLIISCTLFVGAAAIFL 431
Cdd:cd17324 314 R-LAPEARGLASSLYLAAYNLGGALGAALGGLV--LDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
23-431 |
4.11e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 70.27 E-value: 4.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 23 RRAVWRILPILMISYIFAYLDRINVGIAKLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVC 102
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 103 WAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMfALFAAAVPLSGLLGGPLSGWIMehfhNM 182
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLI----LL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 183 HGLAGWKWLFILQGTPSLLVGLVVLKLLPDRIndakwlsadekaimnarvkEDAVDDTTVEQASLGTVLRNGKLWLLTLI 262
Cdd:COG0738 158 GLSLSWHLPYLILAVLLLLLALLFLRSKLPEI-------------------EEEEEEAAGSAASLKSLLKNPRLLLGGLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 263 YFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKHRERRWhLAVIAVMSGVGMVIsALYA 342
Cdd:COG0738 219 IFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRL-LRLSALLAAVGLLL-ALLA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 343 DNLWIAMFGLTLGAAGGLSTLPLFWSLpTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSDLTHSTLTGMLIISCTL 422
Cdd:COG0738 297 PGPWLALIGLALVGLGLSLMFPTIFSL-ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYL 375
|
....*....
gi 817691378 423 FVGAAAIFL 431
Cdd:COG0738 376 LILLLALAL 384
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
80-434 |
5.40e-13 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 69.96 E-value: 5.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 80 QIPSNIILQKFGARRLLAALLVCWAVIAPLTALVsTPFQFYAV---RFMLGLTESGFYPGVILYLSFWFPSYRRGKMFAL 156
Cdd:cd17318 73 QIPGGYLAEKYGAKRVLGYSILITALLTLLTPLA-ARGGYGALivlRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSI 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 157 FAAAVPLSGLLGGPLSGWIMEHFhnmhglaGWKWLFILQGTPSLLVGLVVLKLLPdrindakwlsadekaimnarvkeda 236
Cdd:cd17318 152 AYSGSQFGTVIAMPLSGFLCESL-------GWPSIFYIFGGLGLLWCLLWFFLVL------------------------- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 237 vddttveqaslgtvlrngKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADK 316
Cdd:cd17318 200 ------------------PVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADW 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 317 HReRRWHLAVIAV---MSGVGMVISALyadnlwiamFGLTLGAAGGLSTLP-LFWSLPTAFLGGTMAAVGI--------- 383
Cdd:cd17318 262 LR-SRGILSTTTVrklFTSIGFLGPGV---------FLIALGYLGSNATLAvVFLTLSVGLSGACYSGFLVnhldlapny 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 817691378 384 -----ALINSIGNLAGFVAPYLMGIL--SDLTHSTLTGMLIISCTLFVGAAAIFLIPG 434
Cdd:cd17318 332 agtlmGITNTAATIAGIISPLIVGAIvkNDQTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
52-431 |
1.39e-12 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 68.82 E-value: 1.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 52 LQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRL-LAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTE 130
Cdd:cd17341 23 PVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVfIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 131 SGFYPGvILYLSFWFPSYRRGKMFALFAAA----VPLSGLLGGPLSGWIMEHFHNMhglaGWKWLFILQGTPSLLVGLVv 206
Cdd:cd17341 103 ANFASG-QPWASFWFPKEKIGGAAGGIAGAgnmgVAVSQLLAPLIAGAIVFDGGFV----GWRNAFFVPGILLAIAAVL- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 207 lkllpdrindakwlsadekAIMNARVKEDAVDDTTVEQASLGTVLRNGKLWLLTLIYFCLIAGFYTVSFWLPT-LVRNAG 285
Cdd:cd17341 177 -------------------VLLFGDDLPTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTyFKTRFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 286 VKDVfTVGMLTAIPYAAAIFTMIVASRSADKHRERRWHLAVIAVMS-GVGMVISALYADNLWIAMF-------GLTLGAA 357
Cdd:cd17341 238 LPLV-TAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTiGAALLSLSLPTSGTNLVLFlalfvalGLGAGAG 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 817691378 358 GGLstlpLFWSLPTAFLGGTMAAVGIalINSIGNLAGFVAPYLMGILSDLTHSTLTGMLIISCTLFVGAAAIFL 431
Cdd:cd17341 317 NGS----VFRMVPFIFRRELGAVTGL--VGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
89-433 |
2.95e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 67.61 E-value: 2.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 89 KFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLG 168
Cdd:cd17365 60 RFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 169 GPLSGWIMEHFhnmhglaGWKWLFILQGTPsllvglvvlkllpdrindakwlsadekaimnarvkedavddttveqASLG 248
Cdd:cd17365 140 GFLAAALIPAF-------GWRSVFLLGGVP----------------------------------------------PLIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 249 TVLRNGKLwLLTLIYFCLIAGFYTVSFWLPTLVRNAGVkDVFTVGMLTAIPYAAAIFTMIVASRSADKhRERRWHLAVIA 328
Cdd:cd17365 167 LPLLRGTL-LLWVTFFMGLLLVYLLNSWLPKLMVEAGY-SLSQALTITLLLNIGGVIGSLLLGWLADR-FGPKRVLALFF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 329 VMSGVGMVISALYADNLWIAMFGLTLGAAGGLSTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSDLT 408
Cdd:cd17365 244 ALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAG 323
|
330 340
....*....|....*....|....*
gi 817691378 409 HSTLTGMLIISCTLFVGAAAIFLIP 433
Cdd:cd17365 324 LGPESVFLALAIPAALGALAVLLLR 348
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
30-432 |
5.63e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 66.88 E-value: 5.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 30 LPILMISYIFAYLDRINVGIAKLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVIAPL 109
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 110 TALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFhnmhglAGWK 189
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAT------GGWR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 190 WLFILQGTPSLLVGLVVLKLLPdrinDAKWLSADEKAIMNARVKEDAVDdttveqasLGTVLRNGKLWLLTLIYFCLIAG 269
Cdd:cd17328 155 WAFRVTGVLGVLLAILLLLFVR----EPPRGAAEGGVMAKSTATSFLAD--------LKALAKNPSFILSTLGFTAVSFV 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 270 FYTVSFWLPTLVRNAGV----KDVFTVGMLTAIPYAAAIFTMIVASRSADKHRERR-----WHLAVIAVMSGVGMVISAL 340
Cdd:cd17328 223 TGALAFWAPTFFLRAFGvgdlSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTpradpLVCAVGLLAAAPFLFLALV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 341 YADNLWIAMFGLTLGAAGGLStlpLFWSLPTAFL----GGTMAAVGIALINSIGNLAG-FVAPYLMGILSDLTH----ST 411
Cdd:cd17328 303 LALSNLLLAWVLLFLGEFLLS---LNWAPVFAILlyvvIPTRRSTASAIQILLSHLLGdAGSPYLIGLISDLLRqnkdSP 379
|
410 420
....*....|....*....|.
gi 817691378 412 LTGMLIISCTLFVGAAAIFLI 432
Cdd:cd17328 380 LAEAASLQYALLLCSFVLVLG 400
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
54-431 |
8.44e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 66.49 E-value: 8.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 54 MSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGF 133
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 134 YPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFhnmhglaGWKWLFILQGTPSLLVGLVVlkllpdr 213
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHY-------GWRAAFVVAGLVSILAAVLF------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 214 indakWLSADEKAIMNARVKEdavddTTVEQASLGTVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVG 293
Cdd:cd17475 168 -----WLFYREPPAASAATES-----ASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 294 MLTAIPYAAAIFTMIVASRSADKHRERRwHLAVIAVMSGVGMVISALYADN-----LWIAMFGLTLGAAGGLSTLPLFWS 368
Cdd:cd17475 238 ALLAVAQLGGALGRIGLGRVSDRVFGGR-RRPVLVITAAIAAAALLVLSLLspgtpLWLLVLLLILLGLFAIGWNGLYLT 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 817691378 369 LPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSDLTHSTLTGMLIisCTLFVGAAAIFL 431
Cdd:cd17475 317 LVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLA--LALLLVLAALLL 377
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
27-431 |
2.46e-11 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 64.99 E-value: 2.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 27 WRILPILMISYIFAYLDRINVGIAKLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVI 106
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 107 APLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFhnmhgla 186
Cdd:cd17312 82 NIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY------- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 187 GWKWLFILQGTPSLLVGlvvlkllpdrindakwlsadekAIMNARVKEdavddttveqaslgtvlRNGKLWLLTLIYFCL 266
Cdd:cd17312 155 GWRAAFLVPGIVGLVVA----------------------IILFFFLRD-----------------SPPYVWVLSLAYAFV 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 267 IAGFYTVSFWLPT-LVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKHRERRwhlAVIAVMSGVGMVISALY---- 341
Cdd:cd17312 196 YIVRYACLDWGPLyLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRR---APIAVIYMLLMTLSLALfwff 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 342 -ADNLWIAMFGLTLGAA-GGLStlpLFWSLPTAFLGGTMAAVGIA--LINSIGNLAGFVAPYLMGILSDLTH-STLTGML 416
Cdd:cd17312 273 pHNKLLSIVLLFLIGFFvGGPI---NLIGGAAAQDIGRKEAAGTAtgFVGLFGYLGASLAGLPLGYIIDHYGwSTVFYFL 349
|
410
....*....|....*
gi 817691378 417 IISCTLFVGAAAIFL 431
Cdd:cd17312 350 ISAALLSVLLLLSLW 364
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
89-433 |
4.74e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 64.13 E-value: 4.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 89 KFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLG 168
Cdd:cd17473 61 RFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVF 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 169 GPLSGWImehfhnmhGLAGWKWLFILQGTPSLLVGLVVlkllpdrindakwlsadeKAIMNARVKEDAVDDTTVEQAslg 248
Cdd:cd17473 141 LLLGGAL--------AEIGWRAPFLVYLLALPVLILVL------------------LFLPEPARKSKSAASPGAATA--- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 249 TVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIpyaAAIFTMIVASRSA--DKHRERRWHLAV 326
Cdd:cd17473 192 AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAI---ASLAGAIGALLFGrlKRRLGKRRLLAI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 327 IAVMSGVGMVISALyADNLWIAMFGLTLGAAGGLSTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSD 406
Cdd:cd17473 269 GFALMALGFLLLAL-ASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVN 347
|
330 340
....*....|....*....|....*..
gi 817691378 407 LTHSTLTGMLIISCTLFVGAAAIFLIP 433
Cdd:cd17473 348 LTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
80-417 |
7.09e-09 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 57.45 E-value: 7.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 80 QIPSNIILQKFGARRLLAALLVCWAVIA---PLTALVSTPFQFyAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFAL 156
Cdd:TIGR00894 93 QIPVGYLAGKYVFKWSIGIGMFLSSVISiviPWAAGGGIALVV-FCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGM 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 157 FAAAVPLSGLLGGPLSGWIMEHFhnmhglAGWKWLFILQGTPSLLVGLVVLKLLPDRINDAKWLSADEKAIMNARVKEDa 236
Cdd:TIGR00894 172 STSGFQLGTFIFLPISGWLCESW------GGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQ- 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 237 vDDTTVEQASLGTVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSAD- 315
Cdd:TIGR00894 245 -KGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADf 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 316 -KHRERRWHLAVIAVMSGVGMVISALYadnlwiAMFGLTLGAAGGLSTlpLFWSLPTAFLGGTMAAVGIALINSIGNLAG 394
Cdd:TIGR00894 324 lKSSKTLSLTAARKIFNGIGGLGPGIF------AYALPYLSAAFYLTI--IILTLANAVSSGPLAGVLINSLDLAPRFLG 395
|
330 340
....*....|....*....|....*
gi 817691378 395 FVA--PYLMGILSDLTHSTLTGMLI 417
Cdd:TIGR00894 396 FIKgiTGLPGFIGGLIASTLAGNIL 420
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
56-431 |
2.59e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.68 E-value: 2.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 56 SDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYP 135
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 136 GVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFhnmhglaGWKWLFILQGTPSLLVglvvlkllpdrin 215
Cdd:cd17489 104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-------GFAVLFIVAAVLALLA------------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 216 dakwlsadekAIMNARVKEDAVDDTTVEQASLG--TVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVG 293
Cdd:cd17489 164 ----------LLLVFLVKDPPPVAAEEAEAGTRafRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 294 MLTAIpyaAAIFTMIVASRSADKHRERRwhLAVIAVMSGVGMVISALYADNLWIAMFGLTLGAAGGLSTLPLFWSLPTAF 373
Cdd:cd17489 234 TVYAI---ALLLSRPFSGKLSDRKGPKT--VIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 817691378 374 LGGTMAAVGIALINSIGNLAGFVAPYLMGILSDltHSTLTGMLIISCTLFVGAAAIFL 431
Cdd:cd17489 309 VPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE--LFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
80-432 |
2.71e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.27 E-value: 2.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 80 QIPSNIILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAA 159
Cdd:cd17474 51 MPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 160 AVPLSGLLGGPLSGWImehfhnmhGLAGWKWLFILQGTPSLLVGLVVLKLLPDRINDAKWLSADEKAIMNArvkedavdd 239
Cdd:cd17474 131 ALGLGIAVGPLLGGLL--------AAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKK--------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 240 ttveqaslgtVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKHRE 319
Cdd:cd17474 194 ----------ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 320 RRWHLAVIAVMSGVGMVIsALYADNLWIAMFGLTLGAAGGLSTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAPY 399
Cdd:cd17474 264 ARRILVIGLLLYALSLLL-LGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPL 342
|
330 340 350
....*....|....*....|....*....|...
gi 817691378 400 LMGILsdLTHSTLTGMLIISCTLFVGAAAIFLI 432
Cdd:cd17474 343 LFGLL--LEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
24-310 |
4.12e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 54.43 E-value: 4.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 24 RAVWRILPILMISYIFAYLDRINVGIAKLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCW 103
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 104 AVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFhnmh 183
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL---- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 184 glaGWKWLFILQGTPSLLVGLVVLKLLPDRINDAKWLSAdekAIMNARVKEDAVDDTTVEQASLGTVLRNGKLWLLTLIY 263
Cdd:COG0477 166 ---GWRWIFLINAPLGLLALVLRLRLPESRGLLLALLAL---ALAALLLAALALALLALLLLLLLLLLALLALLLAGAAL 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 817691378 264 FCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVA 310
Cdd:COG0477 240 LLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLL 286
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
238-430 |
6.88e-08 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 54.12 E-value: 6.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 238 DDTTVEQASLGTVLRNGKLWLLTLiYFCLIA-GFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASrSADK 316
Cdd:cd17339 180 AAAAAAPLTKISVWRSPLAWQVTL-FMGLQSlLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVPI-LATR 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 317 HRERRWHLAVIAVMSGVGMV-----ISALYAdnLWIAMFGLTLGAAGGLSTlpLFWSLPTAFLGGTMAAVGIAliNSIGN 391
Cdd:cd17339 258 LKNQRPIVVLLAVLFIIGVLgllfaPTALAL--LWAVLLGLGGGAAFSLAL--TLISLRSSDPAEAAALSGMA--QSVGY 331
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 817691378 392 LAGFVAPYLMGILSDLTHS-TLTGMLIISCTLFVGAAAIF 430
Cdd:cd17339 332 LLAALGPLLFGVLHDLTGSwTAPLVLLLALTVLQLVAGLG 371
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
85-433 |
1.02e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 53.85 E-value: 1.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 85 IILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLS 164
Cdd:cd17371 56 ILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 165 GLLGGPLSGWIMEHFHNMHGlagWKWLFILQGTPSLLVGLVVlkllpdrindakwLSADEKAIMNARVKEDAVDDTTVEQ 244
Cdd:cd17371 136 WLLATLLAALLFPLLPPEIA---WRVLFLLGALPALLVLFIR-------------RFVKEPPQWQAARAARRHFADRPSL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 245 ASLGTVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRnaGVKDVFTVGMLT--AIPYAAAIFTMIVASRSADKHrERRW 322
Cdd:cd17371 200 RELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLT--GERGLSFEGSAGylVVTILGGFLGYLAGGFLADRI-GRRN 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 323 HLAVIAVMSGVGMVISALYA---DNLWIAMFGLTLGAAGGLSTLPLFWS--LPTAfLGGTmaavGIALINSIGNLAGFVA 397
Cdd:cd17371 277 NFALFALGSAISILLYFFLPlspTLILILGFPLGFFASGPFSGMGAYLTelFPTA-VRAT----AQGFCYNVGRIIGALF 351
|
330 340 350
....*....|....*....|....*....|....*..
gi 817691378 398 PYLMGILSDlTHSTLTGMLIISCT-LFVGAAAIFLIP 433
Cdd:cd17371 352 PFLVGFLAT-SGSLGTAIAVFAAVyYIAGLVLALLLP 387
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
80-416 |
1.00e-06 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 50.55 E-value: 1.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 80 QIPSNIILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFY--AVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALF 157
Cdd:cd17381 82 QIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYliAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTIS 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 158 AAAVPLSGLLGGPLSGWIMEHFhnmhglaGWKWLFILQGTPSLLVGLVVLkllpdrindakWLSAdekaimnarvkedav 237
Cdd:cd17381 162 YAGAQLGTVVSLPLSGLICYYL-------DWTYVFYIFGAVGLLWFFLWI-----------WLVM--------------- 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 238 ddttveqaslgtvlrngKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKH 317
Cdd:cd17381 209 -----------------PLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 318 RErRWHLAVIAV---MSGVGMVISALyadnlwiamFGLTLGAAGGLSTLPL-FWSLPTAFLGGTMAAVGIALINsignla 393
Cdd:cd17381 272 RE-KQNFSTVCVrkiFTLIGMIGPAV---------FLLAAGFTGCNYSLAVaFLTISSTLGGFSASGFNINHLD------ 335
|
330 340
....*....|....*....|....*
gi 817691378 394 gfVAPYLMGILSDLTHS--TLTGML 416
Cdd:cd17381 336 --IAPSYAGILLGITNTfaTIPGMV 358
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
85-431 |
2.81e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 49.22 E-value: 2.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 85 IILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGL-TESGFYPGVILYLSfWFPSYRRGKMFALFAAAVPL 163
Cdd:cd06180 56 FLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAaSAFVFVFGSNLVLH-HATAAGRGHLIGLLFAGVGL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 164 SGLLGGPLSgwIMEHFHNMHGLAGWKWLfilqgtpsllvglvvlkllpdrindakWLSADEKAIMNARVKEDAVDDTTVE 243
Cdd:cd06180 135 GIALSGLLV--PAGLGGGLSWRAGWLAL---------------------------ALLSAVLLLLSFLLLRRGPSAPTEA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 244 QASLGTVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVkDVFTVGMLTAIPYAAAIFTMIVASRSADKHRERRWh 323
Cdd:cd06180 186 SAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGA-GSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRA- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 324 LAVIAVMSGVGMVISALYADNLWIAMFGLTLGA---AGGLSTLPLFWSLPTAFLGGTMAAVGIALinSIGNLAGfvaPYL 400
Cdd:cd06180 264 LAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGtfmAITALVMALARELAPPAAPRALALMTASF--GVGQILG---PLL 338
|
330 340 350
....*....|....*....|....*....|.
gi 817691378 401 MGILSDLTHSTLTGMLIISCTLFVGAAAIFL 431
Cdd:cd06180 339 AGWLADATGGFAPALILAAAALVVAALLALL 369
|
|
| MFS_CynX_like |
cd17410 |
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ... |
250-410 |
3.15e-06 |
|
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340968 [Multi-domain] Cd Length: 372 Bit Score: 48.95 E-value: 3.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 250 VLRNGKLWLLTLiYFCLIAGFYT-VSFWLPTLVRNAGVKDVFT---VGMLTAIPYAAAIFTMIVASRSADKhreRRWHLA 325
Cdd:cd17410 190 FFRNRRAWLLAL-YFGLINAGYTsMIAWLPAYYLELGWSAQDSgslLGFMTIFQVLGALVMPALARRSADR---RPLLMG 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 326 VIAVMSG--VGMVISALYADNLWIAMFGLTLGAAGGLSTLPLFWSLPTAFLGGTMAavgiALINSIGNLAGFVAPYLMGI 403
Cdd:cd17410 266 ALAAQLAgfLGLILMPQSLPLLWVALIGLGLGACFSLGLILALDHLRKPRAAGQLA----AFVQGIGFIITGISPWIAGW 341
|
....*..
gi 817691378 404 LSDLTHS 410
Cdd:cd17410 342 LRDSTGS 348
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
256-433 |
5.39e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.05 E-value: 5.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 256 LWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVkDVFTVGMLTAIPYAAAIFTMIVASRSADKHrERRWHLAVIAVMSGVGM 335
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGA-SPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 336 VISALyADNLWIAMFGLTLGAAGGLSTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSDLTHSTLTGM 415
Cdd:COG2814 90 LLCAL-APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170
....*....|....*...
gi 817691378 416 LIISCTLFVGAAAIFLIP 433
Cdd:COG2814 169 VNAVLALLALLLLLRLLP 186
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
235-430 |
8.05e-06 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 47.64 E-value: 8.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 235 DAVDDTTVEQASLGTVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVkdvfTVGMLTAIPYAAAIFTMIVASRSA 314
Cdd:cd17393 180 EAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLG----ASAALAALGYAVFSLAMTVGRLFG 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 315 DKHRER---RWHLAVIAVMSGVGMVIsALYADNLWIAMFGLTLgAAGGLSTLplfwsLPTAF-----LGGTMAAVGIALI 386
Cdd:cd17393 256 DRLVDRfgdVAVLRAGALLAALGLLL-ALLAPSVWVALAGFAL-MGLGLSVV-----VPLAFsaagaLPGLAAGIAVARV 328
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 817691378 387 NSIGNLAGFVAPYLMGILSDLThSTLTGMLIIscTLFVGAAAIF 430
Cdd:cd17393 329 ATLGYLGFLVGPPLIGFLADAT-GLRTAFLVV--ALLALLVALL 369
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
55-357 |
9.80e-06 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 47.30 E-value: 9.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 55 SSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVIAPLTALVSTPF-QFYAVRFMLGLTESGF 133
Cdd:TIGR00886 29 KDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYsVLLLIRLFIGIAGGSF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 134 YPGvILYLSFWFPSYRRGKMFALFAAAvplsGLLGGPLSGWIMehfhnmhgLAGWKWLFILQGTPSLLVGLVVLKLLPDR 213
Cdd:TIGR00886 109 ASC-MPWISFFFPKKIQGTALGLAAGW----GNMGGGVAQFVM--------PPIIGSLIFGGGQPAHLAWGWAFVIVPAG 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 214 IndaKWLSAdekAIMNARVKEDAVDDTTVEQASLGT---VLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVF 290
Cdd:TIGR00886 176 I---LLLPA---LLIFFVGADTPPGKPATGKLSFKEalkVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKV 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 817691378 291 TVGMLTAIPYAAAIFTMIVASRSADK-HRERRWHLAVIAVMSGVGMVISALYADNLWIAMFGLTLGAA 357
Cdd:TIGR00886 250 QAGAYASLGGFLGSLARPAGGAISDRlGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALF 317
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
89-432 |
1.55e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 89 KFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLG 168
Cdd:cd17329 61 RFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 169 GPLSGWIMEHFHNmhglagwkWLFILQGTPSLLVGLVVLKLLPDRINdakwlsadekaimnarvkEDAVDDTTVEQASLG 248
Cdd:cd17329 141 PLLGGLLLLYSFR--------LLFLAAAVLFLLAALVLLFLLPETRP------------------KRRAAEKTEILRGYK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 249 TVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKHRERRWhLAVIA 328
Cdd:cd17329 195 IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKI-LMIGI 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 329 VMSGVGMVISALYADNLW--IAMFGLTLGAAGGLSTLPLFWS--LPTAFLGGTMAAVGIALInsignLAGFVAPYLMGIL 404
Cdd:cd17329 274 LLFAIGFAVLAFANTLAVliLAMIVLTLGEMLVFPAVQTLVAalAPPDKRGSYMGFYALAWG-----LGRAIGPLVGGLL 348
|
330 340
....*....|....*....|....*...
gi 817691378 405 SDLthsTLTGMLIISCTLFVGAAAIFLI 432
Cdd:cd17329 349 LDL---LGPGLPWLILAALGLIAAALLL 373
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
150-431 |
4.23e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.66 E-value: 4.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 150 RGKMFALFAAAVPLSGLLGGPLSGWIMEHFHNMHGlAGWKWLFILQGTPSLLVGLVVLKLLPDRIndakwlsADEKAIMN 229
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAA-LGYRLTALIFAVLGLLAFLLTFFGTKERP-------VPEEEKVS 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 230 ARvkedavddttveqASLGTVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIV 309
Cdd:COG2211 217 LK-------------ESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPL 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 310 ASRSADKHRERRWHLAVIAVMSGVGMVISALYADNLWIAMFGLTLGAAGGLSTLPLFWSL-------PTAFLGGTMAAVG 382
Cdd:COG2211 284 WPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMladvvdyDEWKTGRRREGLY 363
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 817691378 383 IALINSIGNLAGFVAPYLMGILSDL---------THSTLTG----MLIISCTLFVGAAAIFL 431
Cdd:COG2211 364 FGIFTFAIKLGQALAGALAGLLLALfgyvagaaqSPSALTGirllFFLLPAVLLLLAALLLL 425
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
88-194 |
4.34e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 45.24 E-value: 4.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 88 QKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLL 167
Cdd:cd17321 56 DRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAAL 135
|
90 100
....*....|....*....|....*..
gi 817691378 168 GGPLSGWIMEHFhnmhglaGWKWLFIL 194
Cdd:cd17321 136 GPLLGGLLLELF-------GWRWIFLI 155
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
259-433 |
2.17e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.18 E-value: 2.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 259 LTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKHRERRWhLAVIAVMSGVGMVIs 338
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV-LLIGLLLFALGLLL- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 339 ALYADNLWIAMFGLTLGAAGGLSTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSDLTHSTLTGMLII 418
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170
....*....|....*
gi 817691378 419 SCTLFVGAAAIFLIP 433
Cdd:pfam07690 159 ILSLLAAVLLLLPRP 173
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
259-433 |
2.19e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.18 E-value: 2.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 259 LTLIYFCLIAGFYTVSFWLPTLVRNAGVkDVFTVGMLTAIPYAAAIFTMIVASRSADKHRERRWhLAVIAVMSGVGMVIS 338
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGL-SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPV-LLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 339 ALyADNLWIAMFGLTLGAAGGLSTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMGILSDLTHSTLTGMLII 418
Cdd:cd06174 79 AF-APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLI 157
|
170
....*....|....*
gi 817691378 419 SCTLFVGAAAIFLIP 433
Cdd:cd06174 158 AAALALLAAILLLLV 172
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
27-433 |
4.18e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 42.23 E-value: 4.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 27 WRILPILMISYIFAYLDRINVGIAKLQMSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVI 106
Cdd:cd17345 2 WQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 107 APLTALV----STPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMehfhNM 182
Cdd:cd17345 82 NILIGFVpsatSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGL----AI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 183 HGLAGWKWLFILQGTPSLLVGLVVLKLLPDRINDAKWLSADE---KAIMNARVKEDAVDDTTvEQASLGTVLRNGKLWLL 259
Cdd:cd17345 158 FGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEykgDYPEEADGEEEEQELSA-WEIFVKYVLKNKLLWYI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 260 tliyfCLIAGF-YTVSF----WLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADK-HRERRWHLAVIAVMSGV 333
Cdd:cd17345 237 -----AIANVFvYLVRYgildWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKlFKGRRAPTGIIFMILVI 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 334 GMVISALYADNLWIAMfgLTLGAAGGLSTLPlfwslptAFLGGtMAAVGIALINSIGNLAGF-----------VAPYLMG 402
Cdd:cd17345 312 VALIVYWLAPNVLVDL--IALIALGFLIYGP-------VMLIG-LQALELVPKKAAGTAAGLtglfgylggsvLATALIG 381
|
410 420 430
....*....|....*....|....*....|..
gi 817691378 403 ILSDLTHSTLT-GMLIISCTLfvgaAAIFLIP 433
Cdd:cd17345 382 IIVDHFGWNGGfIVLLASCIL----AIIFLAL 409
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
54-196 |
5.47e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.79 E-value: 5.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 54 MSSDLAFSETVYGLGAGIFFIGFFFFQIPSNIILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGF 133
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 817691378 134 YPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLGGPLSGWIMEHFhnmhglaGWKWLFILQG 196
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-------GFATPFLAAA 361
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
83-179 |
1.16e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.03 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 83 SNIILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAV- 161
Cdd:cd17335 253 SSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLLQGLYf 332
|
90
....*....|....*...
gi 817691378 162 PLSGLLGGPLSGWIMEHF 179
Cdd:cd17335 333 GLGGGLGSLIGGYLYEAF 350
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
89-430 |
1.37e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 40.64 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 89 KFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSGLLG 168
Cdd:cd17320 60 RFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 169 GPLSGWIMEHFhnmhglaGWKWLFILQGTPSLLVGLVVLKLLPdrindaKWLSADEKAIMNARVKEDavddttveqasLG 248
Cdd:cd17320 140 PLLGGLLLLFF-------GWRAIFVFLALLGLLLLLLVLLFLP------ETLPEEKRKPLLSSLLRA-----------YK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 249 TVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKHRERR--WHLAV 326
Cdd:cd17320 196 RVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRllRLGLL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 327 IAVMSGVGMVISALYADNLWIAMFGLTLGAAGGLStlplfWSLPTAFLG-----GTMAAVGIALINSIGNLAGFVAPYLM 401
Cdd:cd17320 276 LLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFG-----LIFPNATSLalepfPHVAGTASALLGFLQFLIGALAGALV 350
|
330 340
....*....|....*....|....*....
gi 817691378 402 GILSDLTHSTLTGMLIISCTLFVGAAAIF 430
Cdd:cd17320 351 GLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
81-426 |
1.70e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 1.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 81 IPSNIILQKFGARRLLAAL-LVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFwFPSYRRGKMFALFAA 159
Cdd:cd17490 49 IPLGILSDRIGKRKLFIIIgLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASY-FPPDEAAKAMGLINL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 160 AVPLSGLLGGPLSGWIMEHFhnmhglaGWKWLFILQGTPSLLVGLVVLKLLPDRindakwlsaDEKAIMNARVKEdavdd 239
Cdd:cd17490 128 VNNLGQLIAFLIGGLIAEHF-------GMRAPFLLAALAGVLGFILSLFIKEER---------REKKPVLTELKE----- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 240 ttveqasLGTVLRNGKLWLLTLIYFCL-IAGFYTVSFWLPTLVRNAGVKDvFTVGMLTAIPYA-AAIFTMIVASRSADKH 317
Cdd:cd17490 187 -------LLSVLKDKKLLFFSLLAILQqMITFSTTFGFTPLIAKQLGASS-FQLGLLSIIYLLpNALASLLSGTLFYKKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 318 RERRWHLAVIAVMSGVGMVISalYADNLWIAMFGLTLGAAGGLSTLPLFWSLPTAFLGGTMAAVGIALINSIGNLAGFVA 397
Cdd:cd17490 259 GERNTIIIGFLLLGAYCFLIP--FAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLG 336
|
330 340
....*....|....*....|....*....
gi 817691378 398 PYLMGILSDLThSTLTGMLIISCTLFVGA 426
Cdd:cd17490 337 PVLVGIISEAF-GLQTGFFVIGVIALLAA 364
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
86-404 |
1.80e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.25 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 86 ILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLSG 165
Cdd:cd17503 54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 166 LLGGPLSGWIMEHFhnmhglaGWKWLFILQGTPSLLVGLVVlkllpdrindakwlsadekAIMNARvkedavddttveqa 245
Cdd:cd17503 134 AIGPTLGGWLTDNL-------SWRWIFYINLPIGILALLLA-------------------PLLDLR-------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 246 slgtVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAGVKDVFTVGMLTAIPYAAAIFTMIVASRSADKhRERRWHLA 325
Cdd:cd17503 174 ----LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDK-FGPRLLLL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 326 VIAVMSGVGMVISALYADN---LWIAMFGLTLGAAGGLSTLPLFwSLPTAFLGGTMAAVGIALINSIGNLAGFVAPYLMG 402
Cdd:cd17503 249 AGLLLLALGTLLLAFLTPDtslWLIILPLFIRGLGMGLVFMPLN-TLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327
|
..
gi 817691378 403 IL 404
Cdd:cd17503 328 TL 329
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
245-433 |
2.33e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.84 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 245 ASLGTVLRNGKLWLLTLIYFCLIAGFYTVSFWLPTLVRNAG--VKDVFTVGMLTAIpyaAAIFTMIVASRSADKHRERRW 322
Cdd:cd17352 174 GLLLRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGidESDAAFLLSIIGI---SDIVGRILLGLLADKPRIGRL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 323 HLAVIAV-MSGVGMVISALYADN----LWIAMFGLTLGAAGGLSTLplfwsLPTAFLGGTMAAVGIALINSIGNLAGFVA 397
Cdd:cd17352 251 YLYIFTLlILGLSLLAFPLATTYvgliVFSVLFGFCSGSYSSLTPV-----ILADLVGLEKLSNAYGLVLLFQGLAALVG 325
|
170 180 190
....*....|....*....|....*....|....*.
gi 817691378 398 PYLMGILSDLTHSTLTGMLIISCTLFVGAAAIFLIP 433
Cdd:cd17352 326 PPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
86-428 |
3.76e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.46 E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 86 ILQKFGARRLLAALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLsG 165
Cdd:cd17477 54 LIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGL-G 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 166 LLGGPLSGWIMehfhnmhGLAGWKWLFILQGTPSLLvglvvlkllpdrindakwlsadekAIMNARVKEDAVDDTTVEQA 245
Cdd:cd17477 133 FALGPLLLALV-------GTAGALPFLIAAVLLLLA------------------------LVPLLLTRRAAPEIEEAESI 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 246 SLGTVLRNGKLWLLTliyfCLIAGFYTVSFW--LPTLVRNAGVKDVFTVGMLTAIPYAAAIFtMIVASRSADKHrERRWH 323
Cdd:cd17477 182 SLRRLLRIAPLALLG----AFVAGFLEGAFYslLPLYGLRLGLSVAQAALLLAAFVLGGLLL-QWPLGWLADRF-DRRRV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 324 LAVIAVMSGVGMVISALYADNLWIAMFGLTL--GAAGGLSTLPLFWS---LPTAFLGGTMAAVGIALinSIGNLAG-FVA 397
Cdd:cd17477 256 LLGCALLGALAALLLPLVPGLPLALLVLLFLwgGAAGPLYTLALALAgdrLPGDELVAANAALLLLY--GLGSVIGpLLA 333
|
330 340 350
....*....|....*....|....*....|.
gi 817691378 398 PYLMGILSDLthstltGMLIISCTLFVGAAA 428
Cdd:cd17477 334 GALMDAFGPH------GLFLFLAAVALLFLL 358
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
89-433 |
9.96e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.02 E-value: 9.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 89 KFGARRLL---AALLVCWAVIAPLTALVSTPFQFYAVRFMLGLTESGFYPGVILYLSFWFPSYRRGKMFALFAAAVPLsG 165
Cdd:pfam00083 72 RFGRKKSLliaNVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITF-G 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 166 LLGGPLSGWIMEHFHNMhglAGWKWLFILQGTPSLLVGLVVL--------KLLPDRINDAK----WLSADEKAIMNARVK 233
Cdd:pfam00083 151 ILLAYIFGLGLNKTSNS---DGWRIPLGLQLVPALLLIIGLLflpesprwLVEKGRLEEARevlaKLRGVPDVDRELDEI 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 234 EDAVDDT-TVEQASLGTVLRN-GKLWLLTLIYFCLIAGFYT----VSFWLPTLVRNAGVKDVFTVgmlTAIPYAAAIFTM 307
Cdd:pfam00083 228 KDSLEAGqEAEKASWKELFSTkTRRQRLLIGVMLQIFQQLTginaIFYYSTTIFENLGLSDSFLV---TIIVGVVNFVFT 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817691378 308 IVASRSADKHRERRWHLAVIAVMSGVGMVISA---LYADNLWIAMFGLTLG-----AAGGLSTLPLFWSLPTAFLGGTMA 379
Cdd:pfam00083 305 FIAIFLVDRFGRRPLLLLGAAGMAICFVILGIvalLGVSKSDWAGIVAIVFialfiAFFAMGWGPVPWVIVSELFPLSVR 384
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 817691378 380 AVGIALINSIGNLAGFVAPYLMGILSDLTHSTLTGMLIISCTLFVGAAAIFLIP 433
Cdd:pfam00083 385 SKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVP 438
|
|
| |
