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Conserved domains on  [gi|817163733|ref|WP_046519065|]
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prepilin-type N-terminal cleavage/methylation domain-containing protein [Rheinheimera mesophila]

Protein Classification

pilin( domain architecture ID 11471942)

pilin similar to Pseudomonas aeruginosa fimbrial protein PilA, which is responsible for the adhesive property of the pilus

Gene Ontology:  GO:0007155|GO:0009289|GO:0015628|GO:0015627
SCOP:  4001055

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
1-110 1.05e-19

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


:

Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 78.21  E-value: 1.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817163733   1 MKRNQ-GFTLIELMIVVAIIGILAAIALPAYQDYTAKAKGSNAVASLGGQKIKVAEAYATSGTLGCTDTAGTAIPDCT-- 77
Cdd:COG4969    1 MKKKQkGFTLIELMIVVAIIGILAAIAIPAYQDYVARARVSEALALASPLKTAVEECALENGSLPNCNAGDNGLPATIat 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 817163733  78 --------GNGVLSLTY----DGITATMTPTAPAagsGNITWACA 110
Cdd:COG4969   81 kyvssvsvDNGVITVTGtaalAGLTLTLTPTLNN---GAITWTCS 122
 
Name Accession Description Interval E-value
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
1-110 1.05e-19

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 78.21  E-value: 1.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817163733   1 MKRNQ-GFTLIELMIVVAIIGILAAIALPAYQDYTAKAKGSNAVASLGGQKIKVAEAYATSGTLGCTDTAGTAIPDCT-- 77
Cdd:COG4969    1 MKKKQkGFTLIELMIVVAIIGILAAIAIPAYQDYVARARVSEALALASPLKTAVEECALENGSLPNCNAGDNGLPATIat 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 817163733  78 --------GNGVLSLTY----DGITATMTPTAPAagsGNITWACA 110
Cdd:COG4969   81 kyvssvsvDNGVITVTGtaalAGLTLTLTPTLNN---GAITWTCS 122
PRK10574 PRK10574
putative major pilin subunit; Provisional
 1-116 6.20e-09

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 50.80  E-value: 6.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817163733   1 MKRNQGFTLIELMIVVAIIGILAAIALPAYQDYTAKAKGSNAVASLGGQKIKVAEAYATSGTLGCTDTAGTAIPDCTG-- 78
Cdd:PRK10574   1 MDKQRGFTLIELMVVIAIIAILSAIGIPAYQNYLQKAALTDMLQTFVPYKTAVELCALEHGGLDTCDAGSNGIPSPTTsr 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 817163733  79 --------NGVLSLT----YDGITATMTPTAPAAgSGNITWA--CALTGTGA 116
Cdd:PRK10574  81 yvsamsvaKGVITLTgqesLNGLSVVMTPTWDNA-NGVTGWTrnCNIQSDSA 131
Pilin pfam00114
Pilin (bacterial filament); Proteins with only the short N-terminal methylation site are not ...
 35-110 7.75e-04

Pilin (bacterial filament); Proteins with only the short N-terminal methylation site are not separated from the noise. The Prosite pattern detects those better.


Pssm-ID: 395064  Cd Length: 108  Bit Score: 36.21  E-value: 7.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817163733   35 AKAKGSNAVASLGGQKIKVAEAYATSGTLGCTDTAGTAIPDCTGN-GVLSLTYDG-----ITATMTPTA----------- 97
Cdd:pfam00114   1 ARAQVSEALALASGLKTAVAEYALNEGSFPTAAAADIGLTSSTAIlGVISVTVEGagtgtITATFGGGGasdisgktltl 80

                          90
                  ....*....|....
gi 817163733   98 -PAAGSGNITWACA 110
Cdd:pfam00114  81 tRTANDGSGSWTCG 94
 
Name Accession Description Interval E-value
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
1-110 1.05e-19

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 78.21  E-value: 1.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817163733   1 MKRNQ-GFTLIELMIVVAIIGILAAIALPAYQDYTAKAKGSNAVASLGGQKIKVAEAYATSGTLGCTDTAGTAIPDCT-- 77
Cdd:COG4969    1 MKKKQkGFTLIELMIVVAIIGILAAIAIPAYQDYVARARVSEALALASPLKTAVEECALENGSLPNCNAGDNGLPATIat 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 817163733  78 --------GNGVLSLTY----DGITATMTPTAPAagsGNITWACA 110
Cdd:COG4969   81 kyvssvsvDNGVITVTGtaalAGLTLTLTPTLNN---GAITWTCS 122
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
1-116 1.38e-11

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 57.01  E-value: 1.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817163733   1 MKRNQGFTLIELMIVVAIIGILAAIALPAYQDYTAKAKGSNAVASLGGQKIKVAEAYATSGTLGCTDTAGTAIPDCTGNG 80
Cdd:COG4968    6 RRRQRGFTLIELMIVVAIIGILAAIAIPSYQDYVERARRAEAKAALLELAQAQERYYADNGSYPSALADLGLPASTSGYY 85

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 817163733  81 VLSLTYDGITATMTPTAPAAGSgnitwaCALTGTGA 116
Cdd:COG4968   86 TISIAAAATTYTLTATPQADGT------LTLDQTGV 115
PRK10574 PRK10574
putative major pilin subunit; Provisional
 1-116 6.20e-09

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 50.80  E-value: 6.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817163733   1 MKRNQGFTLIELMIVVAIIGILAAIALPAYQDYTAKAKGSNAVASLGGQKIKVAEAYATSGTLGCTDTAGTAIPDCTG-- 78
Cdd:PRK10574   1 MDKQRGFTLIELMVVIAIIAILSAIGIPAYQNYLQKAALTDMLQTFVPYKTAVELCALEHGGLDTCDAGSNGIPSPTTsr 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 817163733  79 --------NGVLSLT----YDGITATMTPTAPAAgSGNITWA--CALTGTGA 116
Cdd:PRK10574  81 yvsamsvaKGVITLTgqesLNGLSVVMTPTWDNA-NGVTGWTrnCNIQSDSA 131
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-78 4.00e-05

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 39.51  E-value: 4.00e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 817163733   1 MKRNQGFTLIELMIVVAIIGILAAIALPAYQDYTAKAKGSNAVASLGGQKIKVAEAYATSGTLGCTDTAGTAIPDCTG 78
Cdd:COG2165    7 RRRQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALERYRLDNGRYPSSLTGLLADVRGGG 84
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
1-46 1.48e-04

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 37.52  E-value: 1.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 817163733   1 MKRNQGFTLIELMIVVAIIGILAAIALPAYQDYTAKAKGSNAVASL 46
Cdd:COG4970    5 RRRQRGFTLIELLVVLAILAILAAIAVPSFSSLIARQRLRAAANEL 50
Pilin pfam00114
Pilin (bacterial filament); Proteins with only the short N-terminal methylation site are not ...
 35-110 7.75e-04

Pilin (bacterial filament); Proteins with only the short N-terminal methylation site are not separated from the noise. The Prosite pattern detects those better.


Pssm-ID: 395064  Cd Length: 108  Bit Score: 36.21  E-value: 7.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 817163733   35 AKAKGSNAVASLGGQKIKVAEAYATSGTLGCTDTAGTAIPDCTGN-GVLSLTYDG-----ITATMTPTA----------- 97
Cdd:pfam00114   1 ARAQVSEALALASGLKTAVAEYALNEGSFPTAAAADIGLTSSTAIlGVISVTVEGagtgtITATFGGGGasdisgktltl 80

                          90
                  ....*....|....
gi 817163733   98 -PAAGSGNITWACA 110
Cdd:pfam00114  81 tRTANDGSGSWTCG 94
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 1-16 2.09e-03

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 33.50  E-value: 2.09e-03
                          10
                  ....*....|....*.
gi 817163733    1 MKRNQGFTLIELMIVV 16
Cdd:pfam07963   1 MRKQRGFTLIELLVAL 16
ComGC COG4537
Competence protein ComGC [Mobilome: prophages, transposons];
1-16 3.08e-03

Competence protein ComGC [Mobilome: prophages, transposons];


Pssm-ID: 443603 [Multi-domain]  Cd Length: 108  Bit Score: 34.90  E-value: 3.08e-03
                         10
                 ....*....|....*.
gi 817163733   1 MKRNQGFTLIELMIVV 16
Cdd:COG4537    8 LKKEKGFTLIEMLIVL 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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