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Conserved domains on  [gi|815697066|ref|WP_046430634|]
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[Fe-Fe] hydrogenase large subunit C-terminal domain-containing protein [Phascolarctobacterium faecium]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nar1 super family cl34792
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
16-322 3.35e-57

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


The actual alignment was detected with superfamily member COG4624:

Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 195.24  E-value: 3.35e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066  16 CQGCVTCVKACPTEAIRVRNGKAELIEARCIDCGECLRRCGYHAIVaETDKLEETEQFKYN----IALPPPSLYAQFPPE 91
Cdd:COG4624   93 CKNCYPCVRACPVKAIKVDDGKAEIDEEKCISCGQCVAVCPFGAIT-EKSDIEKVKKALKDpekvVAQVAPAVRGQFGGT 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066  92 TSAAAIWEGLHRLGFDEIFDVAVASEYISLEIAAYL-KNYNGGRKPLISCTCPAVLRLIQVKFPELIKQVVPVLPPTEAA 170
Cdd:COG4624  172 VTPGKLVAALKKLGFDDVFETAFGADLTIMEEAKELlERLKKGKLPMITSCCPAWVKLIEKYYPELLPNLSPCKSPMQAF 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066 171 AIYVKNEvmqrtglKSEEIGVWFIAPCPSK-----NANIRQSVDVrhtqingSLSISEIyGKILKIMG---GEIQPDKKV 242
Cdd:COG4624  252 GALIKTY-------YAPDIKVVFIGPCIAKkfeakRPEMKGDVDY-------VLTFREL-ARMIKEAGidlANLEEEEFD 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066 243 TAGSSYGMSWGSYGGELEAAG------IENGL-----AVHGINDVYDVLEQISLNKMrDVDYVECSACSGGCIGGPLT-- 309
Cdd:COG4624  317 NESSGAGRIFGVTGGVMEAALrtayelLPDGLelkvaVVSGLKNCRKLLEEIKAGKI-DYHFIEVMACPGGCIGGPGQpi 395

                        330
                 ....*....|....
gi 815697066 310 -AENKFVAEKNLKL 322
Cdd:COG4624  396 pPGSLEKRRKRVAL 409
FeS pfam04060
Putative Fe-S cluster; This family includes a domain with four conserved cysteines that ...
 387-419 3.18e-09

Putative Fe-S cluster; This family includes a domain with four conserved cysteines that probably form an Fe-S redox cluster.


:

Pssm-ID: 461150 [Multi-domain]  Cd Length: 33  Bit Score: 52.05  E-value: 3.18e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 815697066  387 LPGLDCGACGAPSCQCLAEDIVQGKANEIDCIF 419
Cdd:pfam04060   1 LPGTNCGACGYPGCRAFAEAVVAGEAKINDCPP 33
 
Name Accession Description Interval E-value
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
16-322 3.35e-57

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 195.24  E-value: 3.35e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066  16 CQGCVTCVKACPTEAIRVRNGKAELIEARCIDCGECLRRCGYHAIVaETDKLEETEQFKYN----IALPPPSLYAQFPPE 91
Cdd:COG4624   93 CKNCYPCVRACPVKAIKVDDGKAEIDEEKCISCGQCVAVCPFGAIT-EKSDIEKVKKALKDpekvVAQVAPAVRGQFGGT 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066  92 TSAAAIWEGLHRLGFDEIFDVAVASEYISLEIAAYL-KNYNGGRKPLISCTCPAVLRLIQVKFPELIKQVVPVLPPTEAA 170
Cdd:COG4624  172 VTPGKLVAALKKLGFDDVFETAFGADLTIMEEAKELlERLKKGKLPMITSCCPAWVKLIEKYYPELLPNLSPCKSPMQAF 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066 171 AIYVKNEvmqrtglKSEEIGVWFIAPCPSK-----NANIRQSVDVrhtqingSLSISEIyGKILKIMG---GEIQPDKKV 242
Cdd:COG4624  252 GALIKTY-------YAPDIKVVFIGPCIAKkfeakRPEMKGDVDY-------VLTFREL-ARMIKEAGidlANLEEEEFD 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066 243 TAGSSYGMSWGSYGGELEAAG------IENGL-----AVHGINDVYDVLEQISLNKMrDVDYVECSACSGGCIGGPLT-- 309
Cdd:COG4624  317 NESSGAGRIFGVTGGVMEAALrtayelLPDGLelkvaVVSGLKNCRKLLEEIKAGKI-DYHFIEVMACPGGCIGGPGQpi 395

                        330
                 ....*....|....
gi 815697066 310 -AENKFVAEKNLKL 322
Cdd:COG4624  396 pPGSLEKRRKRVAL 409
Fe_hyd_lg_C pfam02906
Iron only hydrogenase large subunit, C-terminal domain;
74-307 8.09e-18

Iron only hydrogenase large subunit, C-terminal domain;


Pssm-ID: 397172  Cd Length: 277  Bit Score: 83.44  E-value: 8.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066   74 KYNIALPPPSLYAQF------PPETSAAAIWEGLHRLGFDEIFDVAVASEYISLEIAAYLKNY--NGGRKPLI-SCtCPA 144
Cdd:pfam02906   1 KKVVAQIAPAVRGAFgeefglPPTVTTGKLVAALRKLGFDYVFDTAFGADLTIMEEATEFLERleKGKKLPMFtSC-CPG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066  145 VLRLIQVKFPELIKQVVPVLPPTEAAAIYVKNEVMQRTGLKseeigVWFIAPCPSKNANIR-------QSVDVrhtqing 217
Cdd:pfam02906  80 WVKYVEKYYPELLPNLSTCKSPMQMFGALIKTYYAEDLKIY-----VVSIMPCTAKKFEAArpemkgdRDVDA------- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066  218 SLSISEIyGKILKIMG------GEIQPDKKVTAGSSYGMSWGSYGGELEAA-------------------------GIE- 265
Cdd:pfam02906 148 VLTTREL-AAMIKEAGidfaklEDEEFDNPLGESSGAGRIFGVTGGVMEAAlrtayelltgkelpaiefkevrgleGIKe 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 815697066  266 ----------NGLAVHGINDVYDVLEQISLNKMrDVDYVECSACSGGCIGGP 307
Cdd:pfam02906 227 atveiggttvKVAVVSGLKNARKLLEKIKAGEL-KYHFIEVMACPGGCIGGG 277
FeS pfam04060
Putative Fe-S cluster; This family includes a domain with four conserved cysteines that ...
 387-419 3.18e-09

Putative Fe-S cluster; This family includes a domain with four conserved cysteines that probably form an Fe-S redox cluster.


Pssm-ID: 461150 [Multi-domain]  Cd Length: 33  Bit Score: 52.05  E-value: 3.18e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 815697066  387 LPGLDCGACGAPSCQCLAEDIVQGKANEIDCIF 419
Cdd:pfam04060   1 LPGTNCGACGYPGCRAFAEAVVAGEAKINDCPP 33
PRK13795 PRK13795
hypothetical protein; Provisional
 11-55 6.68e-09

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 58.08  E-value: 6.68e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 815697066  11 LLRSQ-CQGCVTCVKACPTEAIRVRNGKA--ELIEARCIDCGECLRRC 55
Cdd:PRK13795 577 LRRAAeCVGCGVCVGACPTGAIRIEEGKRkiSVDEEKCIHCGKCTEVC 624
COG2000 COG2000
Uncharacterized Fe-S cluster-containing protein [General function prediction only];
380-439 1.99e-08

Uncharacterized Fe-S cluster-containing protein [General function prediction only];


Pssm-ID: 441603 [Multi-domain]  Cd Length: 212  Bit Score: 54.29  E-value: 1.99e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066 380 MEEVLRSLPGLDCGACGAPSCQCLAEDIVQGKANEIDCIFKLRSSVKRLAHGMLELAKQI 439
Cdd:COG2000    1 MIGKTWLLPGLNCGACGYKTCRDFAAAVYQGKAELEMCPFYMRERFESNSNLVVEELPNG 60
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 15-66 2.97e-07

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 49.31  E-value: 2.97e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 815697066  15 QCQGC--VTCVKACPTEAI-RVRNGKAELIEARCIDCGECLRRCGYHAIVAETDK 66
Cdd:cd04410   49 SCMHCedPPCVKACPTGAIyKDEDGIVLIDEDKCIGCGSCVEACPYGAIVFDPEP 103
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 16-60 1.83e-05

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 46.01  E-value: 1.83e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 815697066  16 CQGCVTCVKACPTEAIRVRNGKAElIEARCIDCGECLRRCGYHAI 60
Cdd:NF038196 187 CIGCGICAKVCPVNNIEMEDGKPV-WGHNCTHCLACIHRCPKEAI 230
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
373-412 4.60e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 41.84  E-value: 4.60e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 815697066 373 AMKKFE-----KMEEVLRSLPGLDCGACGAPSCQCLAEDIVQGKA 412
Cdd:PRK07118  25 ASKKFAveedpRVEAVREVLPGANCGGCGYPGCDGYAEAVVNGDA 69
 
Name Accession Description Interval E-value
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
16-322 3.35e-57

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 195.24  E-value: 3.35e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066  16 CQGCVTCVKACPTEAIRVRNGKAELIEARCIDCGECLRRCGYHAIVaETDKLEETEQFKYN----IALPPPSLYAQFPPE 91
Cdd:COG4624   93 CKNCYPCVRACPVKAIKVDDGKAEIDEEKCISCGQCVAVCPFGAIT-EKSDIEKVKKALKDpekvVAQVAPAVRGQFGGT 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066  92 TSAAAIWEGLHRLGFDEIFDVAVASEYISLEIAAYL-KNYNGGRKPLISCTCPAVLRLIQVKFPELIKQVVPVLPPTEAA 170
Cdd:COG4624  172 VTPGKLVAALKKLGFDDVFETAFGADLTIMEEAKELlERLKKGKLPMITSCCPAWVKLIEKYYPELLPNLSPCKSPMQAF 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066 171 AIYVKNEvmqrtglKSEEIGVWFIAPCPSK-----NANIRQSVDVrhtqingSLSISEIyGKILKIMG---GEIQPDKKV 242
Cdd:COG4624  252 GALIKTY-------YAPDIKVVFIGPCIAKkfeakRPEMKGDVDY-------VLTFREL-ARMIKEAGidlANLEEEEFD 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066 243 TAGSSYGMSWGSYGGELEAAG------IENGL-----AVHGINDVYDVLEQISLNKMrDVDYVECSACSGGCIGGPLT-- 309
Cdd:COG4624  317 NESSGAGRIFGVTGGVMEAALrtayelLPDGLelkvaVVSGLKNCRKLLEEIKAGKI-DYHFIEVMACPGGCIGGPGQpi 395

                        330
                 ....*....|....
gi 815697066 310 -AENKFVAEKNLKL 322
Cdd:COG4624  396 pPGSLEKRRKRVAL 409
Fe_hyd_lg_C pfam02906
Iron only hydrogenase large subunit, C-terminal domain;
74-307 8.09e-18

Iron only hydrogenase large subunit, C-terminal domain;


Pssm-ID: 397172  Cd Length: 277  Bit Score: 83.44  E-value: 8.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066   74 KYNIALPPPSLYAQF------PPETSAAAIWEGLHRLGFDEIFDVAVASEYISLEIAAYLKNY--NGGRKPLI-SCtCPA 144
Cdd:pfam02906   1 KKVVAQIAPAVRGAFgeefglPPTVTTGKLVAALRKLGFDYVFDTAFGADLTIMEEATEFLERleKGKKLPMFtSC-CPG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066  145 VLRLIQVKFPELIKQVVPVLPPTEAAAIYVKNEVMQRTGLKseeigVWFIAPCPSKNANIR-------QSVDVrhtqing 217
Cdd:pfam02906  80 WVKYVEKYYPELLPNLSTCKSPMQMFGALIKTYYAEDLKIY-----VVSIMPCTAKKFEAArpemkgdRDVDA------- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066  218 SLSISEIyGKILKIMG------GEIQPDKKVTAGSSYGMSWGSYGGELEAA-------------------------GIE- 265
Cdd:pfam02906 148 VLTTREL-AAMIKEAGidfaklEDEEFDNPLGESSGAGRIFGVTGGVMEAAlrtayelltgkelpaiefkevrgleGIKe 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 815697066  266 ----------NGLAVHGINDVYDVLEQISLNKMrDVDYVECSACSGGCIGGP 307
Cdd:pfam02906 227 atveiggttvKVAVVSGLKNARKLLEKIKAGEL-KYHFIEVMACPGGCIGGG 277
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 7-66 6.69e-14

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 66.23  E-value: 6.69e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066   7 HSIRLLRSQCQGCVTCVKACPTEAIRVRNGKAELIEARCIDCGECLRRCGYHAIVAETDK 66
Cdd:COG2221    8 WPPKIDEEKCIGCGLCVAVCPTGAISLDDGKLVIDEEKCIGCGACIRVCPTGAIKGEKPK 67
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
16-78 3.14e-12

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 61.67  E-value: 3.14e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 815697066  16 CQGCVTCVKACPTEAIRVRNGKAELIEARCIDCGECLRRCGYHAIVAETDkleETEQFKYNIA 78
Cdd:COG2768   13 CIGCGACVKVCPVGAISIEDGKAVIDPEKCIGCGACIEVCPVGAIKIEWE---EDEEFQEKMA 72
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 16-68 1.46e-09

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 54.28  E-value: 1.46e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 815697066  16 CQGCVTCVKACPTEAIRVRNGKAELIEARCIDCGECLRRCGYHAIVAETDKLE 68
Cdd:COG4231   24 CTGCGACVKVCPADAIEEGDGKAVIDPDLCIGCGSCVQVCPVDAIKLEKRVPE 76
FeS pfam04060
Putative Fe-S cluster; This family includes a domain with four conserved cysteines that ...
 387-419 3.18e-09

Putative Fe-S cluster; This family includes a domain with four conserved cysteines that probably form an Fe-S redox cluster.


Pssm-ID: 461150 [Multi-domain]  Cd Length: 33  Bit Score: 52.05  E-value: 3.18e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 815697066  387 LPGLDCGACGAPSCQCLAEDIVQGKANEIDCIF 419
Cdd:pfam04060   1 LPGTNCGACGYPGCRAFAEAVVAGEAKINDCPP 33
PRK13795 PRK13795
hypothetical protein; Provisional
 11-55 6.68e-09

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 58.08  E-value: 6.68e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 815697066  11 LLRSQ-CQGCVTCVKACPTEAIRVRNGKA--ELIEARCIDCGECLRRC 55
Cdd:PRK13795 577 LRRAAeCVGCGVCVGACPTGAIRIEEGKRkiSVDEEKCIHCGKCTEVC 624
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
15-60 1.91e-08

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 52.74  E-value: 1.91e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 815697066  15 QCQGCVT--CVKACPTEAIRVRNGKAELIEARCIDCGECLRRCGYHAI 60
Cdd:COG1142   51 QCRHCEDapCAEVCPVGAITRDDGAVVVDEEKCIGCGLCVLACPFGAI 98
COG2000 COG2000
Uncharacterized Fe-S cluster-containing protein [General function prediction only];
380-439 1.99e-08

Uncharacterized Fe-S cluster-containing protein [General function prediction only];


Pssm-ID: 441603 [Multi-domain]  Cd Length: 212  Bit Score: 54.29  E-value: 1.99e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066 380 MEEVLRSLPGLDCGACGAPSCQCLAEDIVQGKANEIDCIFKLRSSVKRLAHGMLELAKQI 439
Cdd:COG2000    1 MIGKTWLLPGLNCGACGYKTCRDFAAAVYQGKAELEMCPFYMRERFESNSNLVVEELPNG 60
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 13-60 3.47e-08

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 50.11  E-value: 3.47e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 815697066  13 RSQCQGCVTCVKACPTEAIRVRNGKAELI-EARCIDCGECLRRCGYHAI 60
Cdd:COG1149   10 EEKCIGCGLCVEVCPEGAIKLDDGGAPVVdPDLCTGCGACVGVCPTGAI 58
Fer4_9 pfam13187
4Fe-4S dicluster domain;
15-60 4.31e-08

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 49.47  E-value: 4.31e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 815697066   15 QCQGCVTCVKACPTEAIRVRNGK----AELIEARCIDCGECLRRCGYHAI 60
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVPDLVGqtirGDIAGLACIGCGACVDACPRGAI 50
NapF COG1145
Ferredoxin [Energy production and conversion];
16-68 9.09e-08

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 52.80  E-value: 9.09e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 815697066  16 CQGCVTCVKACPTEAIRVRNGKAELI--EARCIDCGECLRRCGYHAIVAETDKLE 68
Cdd:COG1145  184 CIGCGLCVKVCPTGAIRLKDGKPQIVvdPDKCIGCGACVKVCPVGAISLEPKEIE 238
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
16-62 1.61e-07

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 52.63  E-value: 1.61e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 815697066  16 CQGCVTCVKACPTEAIRVRNGKAELIEARCIDCGECLRRCGYHAIVA 62
Cdd:PRK07118 215 CIGCGKCVKACPAGAITMENNLAVIDQEKCTSCGKCVEKCPTKAIRI 261
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 16-71 2.68e-07

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 47.43  E-value: 2.68e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066  16 CQGCVTCVKACPTEAIRVRNGKAELI----EARCIDCGECLRRCGYHAIVAETDKLEETE 71
Cdd:COG1143    4 CIGCGLCVRVCPVDAITIEDGEPGKVyvidPDKCIGCGLCVEVCPTGAISMTPFELAVED 63
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 15-66 2.97e-07

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 49.31  E-value: 2.97e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 815697066  15 QCQGC--VTCVKACPTEAI-RVRNGKAELIEARCIDCGECLRRCGYHAIVAETDK 66
Cdd:cd04410   49 SCMHCedPPCVKACPTGAIyKDEDGIVLIDEDKCIGCGSCVEACPYGAIVFDPEP 103
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 15-60 4.24e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 49.23  E-value: 4.24e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 815697066  15 QCQGCVtCVKACPTEAIRVRNGKAELIEARCIDCGECLRRCGYHAI 60
Cdd:cd16367   59 HCVDPV-CMIGCPTGAIHRDDGGEVVISDACCGCGNCASACPYGAI 103
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 15-60 4.68e-07

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 49.18  E-value: 4.68e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 815697066  15 QCQGCVT--CVKACPTEAIRVRNGKAELIEARCIDCGECLRRCGYHAI 60
Cdd:cd10554   55 QCRQCEDapCANVCPVGAISQEDGVVQVDEERCIGCKLCVLACPFGAI 102
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 16-61 5.93e-07

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 48.55  E-value: 5.93e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 815697066  16 CQGCVTCVKACPTEAIRV-RNGKAELIEARCIDCGECLRRCGYHAIV 61
Cdd:cd10549   80 CIGCGLCVKVCPVDAITLeDELEIVIDKEKCIGCGICAEVCPVNAIK 126
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 14-69 6.10e-07

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 46.63  E-value: 6.10e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 815697066  14 SQCQGCVTCVKACPTEAIRVRNGKAELIEAR---CIDCGECLRRCGYHAIVAETDKLEE 69
Cdd:COG1146    8 DKCIGCGACVEVCPVDVLELDEEGKKALVINpeeCIGCGACELVCPVGAITVEDDEPEE 66
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
13-60 1.04e-06

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 50.06  E-value: 1.04e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 815697066  13 RSQCQGCVTCVKACPTEaIRVRNGkaELIEARCIDCGECLRRCGYHAI 60
Cdd:COG0348  209 RGDCIDCGLCVKVCPMG-IDIRKG--EINQSECINCGRCIDACPKDAI 253
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 15-74 1.46e-06

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 47.39  E-value: 1.46e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 815697066  15 QCQGCVTCVKACPTEAIRVRNGKA-----ELIEARCIDCGECLRRCGYHAIVAETDKLEETEQFK 74
Cdd:cd10549    7 KCIGCGICVKACPTDAIELGPNGAiargpEIDEDKCVFCGACVEVCPTGAIELTPEGKEYVPKEK 71
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 19-66 2.51e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 47.25  E-value: 2.51e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 815697066  19 CVTCVKACPTEAIR--------VRNGKAELIEARCI------DCGECLRRCGYHAIVAETDK 66
Cdd:cd16373   59 CDACVEVCPTGALRpldleeqkVKMGVAVIDKDRCLawqggtDCGVCVEACPTEAIAIVLED 120
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 9-63 3.03e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 46.50  E-value: 3.03e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 815697066   9 IRLLRSQCQGCVTCVKACPTEAIRVRNGKAELIeaRCIDCGECLRRCGYHAIVAE 63
Cdd:cd16370   78 VVLDKEKCIGCGNCVKACIVGAIFWDEETNKPI--ICIHCGYCARYCPHDVLAME 130
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
16-60 4.76e-06

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 49.09  E-value: 4.76e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 815697066  16 CQGCVTCVKACPTEAIRVRN-GKAELIEARCIDCGECLRRCGYHAI 60
Cdd:COG1148  498 CTGCGRCVEVCPYGAISIDEkGVAEVNPALCKGCGTCAAACPSGAI 543
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
16-61 8.70e-06

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 47.24  E-value: 8.70e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 815697066  16 CQGCVTCVKACPTEAIRVRNGKAELIEARCIDCGECLRRCGYHAIV 61
Cdd:PRK07118 141 CLGLGSCVAACPFDAIHIENGLPVVDEDKCTGCGACVKACPRNVIE 186
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 16-60 1.83e-05

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 46.01  E-value: 1.83e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 815697066  16 CQGCVTCVKACPTEAIRVRNGKAElIEARCIDCGECLRRCGYHAI 60
Cdd:NF038196 187 CIGCGICAKVCPVNNIEMEDGKPV-WGHNCTHCLACIHRCPKEAI 230
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 16-55 2.30e-05

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 45.76  E-value: 2.30e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 815697066  16 CQGCVTCVKACPTEAIRV-RNGKAELIEARCIDCGECLRRC 55
Cdd:COG2878  139 CIGCGDCIKACPFDAIVGaAKGMHTVDEDKCTGCGLCVEAC 179
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 16-55 2.64e-05

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 41.36  E-value: 2.64e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 815697066   16 CQGCVTCVKACPTEAIRV-------RNGKAELIEARCIDCGECLRRC 55
Cdd:pfam12838   1 CIGCGACVAACPVGAITLdevgekkGTKTVVIDPERCVGCGACVAVC 47
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 15-60 3.45e-05

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 44.55  E-value: 3.45e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 815697066  15 QCQGCVT--CVKACPTEAIRVR-NGKAELIEARCIDCGECLRRCGYHAI 60
Cdd:COG0437   59 LCNHCDDppCVKVCPTGATYKReDGIVLVDYDKCIGCRYCVAACPYGAP 107
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 16-61 3.57e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 43.33  E-value: 3.57e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 815697066  16 CQGCVT--CVKACPTEAIRV--RNGKAELIEARCIDCGECLRRCGYHAIV 61
Cdd:cd10550   49 CRQCEDapCVEACPVGAISRdeETGAVVVDEDKCIGCGMCVEACPFGAIR 98
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 8-60 6.34e-05

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 43.16  E-value: 6.34e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 815697066   8 SIRLLRSQCQGCV--TCVKACPTEAI-RVRNGKAELIEARCIDCGECLRRCGYHAI 60
Cdd:cd16366   62 SWLFRKDQCMHCTdaGCLAACPTGAIiRTETGTVVVDPETCIGCGYCVNACPFDIP 117
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 9-55 8.66e-05

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 40.31  E-value: 8.66e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 815697066    9 IRLLRSQCQGCVTCVKACPTEAIRVRNGKAELIEA-------RCIDCGECLRRC 55
Cdd:pfam13237   2 VVIDPDKCIGCGRCTAACPAGLTRVGAIVERLEGEavrigvwKCIGCGACVEAC 55
PRK09898 PRK09898
ferredoxin-like protein;
2-66 1.04e-04

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 43.29  E-value: 1.04e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815697066   2 AGGYFHSIRLLRSQCQGCVT--CVKACPTEAIRV--RNGKAELIEARCIDCGECLRRCGYH-AIVAETDK 66
Cdd:PRK09898 109 GGGLYGDLNYTADTCRQCKEpqCMNVCPIGAITWqqKEGCITVDHKRCIGCSACTTACPWMmATVNTESK 178
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 16-69 1.39e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 41.61  E-value: 1.39e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 815697066  16 CQGCVTCVKACPTEAIRVR---------NGKAELIEARCIDCGECLRRCGYHAIVAETDKLEE 69
Cdd:cd10549   42 CVFCGACVEVCPTGAIELTpegkeyvpkEKEAEIDEEKCIGCGLCVKVCPVDAITLEDELEIV 104
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 5-60 1.85e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 43.86  E-value: 1.85e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 815697066   5 YFHSIRLLRSQCQGC--VTCVKACPTEAIRVRNGKAELIEARCIDCGECLRRCGYHAI 60
Cdd:PRK12809  45 VGKGQAANPVACHHCnnAPCVTACPVNALTFQSDSVQLDEQKCIGCKRCAIACPFGVV 102
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 12-55 2.23e-04

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 41.52  E-value: 2.23e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 815697066  12 LRSQCQGCV--TCVKACPTEAI-RVRNGKAELIEARCIDCGECLRRC 55
Cdd:cd10562   66 RKRQCMHCTdaACVKVCPTGALyKTENGAVVVDEDKCIGCGYCVAAC 112
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 9-55 2.43e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 40.78  E-value: 2.43e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 815697066   9 IRLLRSQCQGCVTCVKACPTEAIRVRNGKAEliEARCIDCGECLRRC 55
Cdd:cd16372   72 VMINKKLCVGCLMCVGFCPEGAMFKHEDYPE--PFKCIACGICVKAC 116
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 11-61 2.70e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 41.09  E-value: 2.70e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 815697066  11 LLRSQCQGCVTCVKACPTEAI----RVRNGKAELIEARCIDCGECLRRC---GYHAIV 61
Cdd:cd16373   94 LAWQGGTDCGVCVEACPTEAIaivlEDDVLRPVVDEDKCVGCGLCEYVCpvePPKAIV 151
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
373-412 4.60e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 41.84  E-value: 4.60e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 815697066 373 AMKKFE-----KMEEVLRSLPGLDCGACGAPSCQCLAEDIVQGKA 412
Cdd:PRK07118  25 ASKKFAveedpRVEAVREVLPGANCGGCGYPGCDGYAEAVVNGDA 69
Fer4_18 pfam13746
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 16-55 5.40e-04

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404610 [Multi-domain]  Cd Length: 114  Bit Score: 39.69  E-value: 5.40e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 815697066   16 CQGCVTCVKACPTeAIRVRNGkaelIEARCIDCGECLRRC 55
Cdd:pfam13746  61 CIDCESCVQVCPT-GIDIRKG----LQLECINCGLCIDAC 95
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 22-61 6.48e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 39.85  E-value: 6.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 815697066  22 CVKACPTEAIRVR-NGKAELIEARCIDCGECLRRCGYHAIV 61
Cdd:cd16371   62 CVKVCPTGAITKReDGIVVVDQDKCIGCGYCVWACPYGAPQ 102
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 14-65 8.76e-04

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 40.02  E-value: 8.76e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 815697066  14 SQCQGCVTCVKACPTEAIRV-----RNGKA-ELIEARCIDCGECLRRCGYHAIVAETD 65
Cdd:PRK12387  38 QQCIGCAACVNACPSNALTVetdlaTGELAwEFNLGRCIFCGRCEEVCPTAAIKLSQE 95
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 16-66 9.47e-04

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 41.02  E-value: 9.47e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 815697066  16 CQGCVTCVKACPTEAIRVRNGKAELIE-ARCIDCGECLRRCGYHAIVAETDK 66
Cdd:PRK00783 171 CDECEKCVEACPRGVLELKEGKLVVTDlLNCSLCKLCERACPGKAIRVSDDE 222
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 19-55 1.21e-03

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 39.15  E-value: 1.21e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 815697066  19 CVTCVKACPTEAIRVR---NGKA--ELIEARCIDCGECLRRC 55
Cdd:cd10564   88 CRSCQDACPTQAIRFRprlGGIAlpELDADACTGCGACVSVC 129
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 373-412 1.52e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 40.36  E-value: 1.52e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 815697066 373 AMKKF-----EKMEEVLRSLPGLDCGACGAPSCQCLAEDIVQGKA 412
Cdd:COG2878   25 ASKKFkveedPRVEEIDALLPGANCGQCGYPGCRPYAEAIAEGEA 69
PRK14494 PRK14494
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing ...
 389-417 3.67e-03

putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional


Pssm-ID: 237731 [Multi-domain]  Cd Length: 229  Bit Score: 38.81  E-value: 3.67e-03
                         10        20
                 ....*....|....*....|....*....
gi 815697066 389 GLDCGACGApSCQCLAEDIVQGKANEIDC 417
Cdd:PRK14494 150 NLNCGHCGF-NCKGFAKAIVKGEAKWDDC 177
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 14-61 4.16e-03

hydrogenase 4 subunit H; Validated


Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 38.19  E-value: 4.16e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 815697066  14 SQCQGCVTCVKACPTEAIRVRNGKA------ELIEARCIDCGECLRRCGYHAIV 61
Cdd:PRK08222  38 SQCIACGACTCACPANALTIQTDDQqnsrtwQLYLGRCIYCGRCEEVCPTRAIQ 91
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 13-71 5.39e-03

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 36.74  E-value: 5.39e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 815697066  13 RSQCQGCVTCVKACPTEAI----RVRngKAELIEARCIDCGECLRRCGYHAIVAETDKLEETE 71
Cdd:PRK08348  41 VDKCVGCRMCVTVCPAGVFvylpEIR--KVALWTGRCVFCGQCVDVCPTGALQMSDDFLLASY 101
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 33-66 6.56e-03

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 35.09  E-value: 6.56e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 815697066  33 VRNGKAELIEARCIDCGECLRRCGYHAIVAETDK 66
Cdd:COG1149    1 VKRKIPVIDEEKCIGCGLCVEVCPEGAIKLDDGG 34
RNAP_D cd07030
D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is ...
 16-66 8.38e-03

D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. A single distinct RNAP complex is found in archaea, which may be responsible for the synthesis of all RNAs. The archaeal RNAP harbors homologues of all eukaryotic RNAP II subunits with two exceptions (RPB8 and RPB9). The 12 archaeal subunits are designated by letters and can be divided into three functional groups that are engaged in: (I) catalysis (A'/A", B'/B" or B); (II) assembly (L, N, D and P); and (III) auxiliary functions (F, E, H and K). The D subunit is equivalent to the RPB3 subunit of eukaryotic RNAP II. It contains two subdomains: one subdomain is similar the eukaryotic Rpb11/AC19/archaeal L subunit which is involved in dimerization, and the other is an inserted beta sheet subdomain. The assembly of the two largest archaeal RNAP subunits that provide most of the enzyme's catalytic functions depends on the presence of the archaeal D/L heterodimer.


Pssm-ID: 132908 [Multi-domain]  Cd Length: 259  Bit Score: 38.02  E-value: 8.38e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 815697066  16 CQGCVTCVKACPTEAIRVRNGKA-ELIEARCIDCGECLRRCGYHAIVAETDK 66
Cdd:cd07030  171 CDGCGKCVEECPRGVLELEEGKVvVEDLEDCSLCKLCERACDAGAIRVGWDE 222
PRK13409 PRK13409
ribosome biogenesis/translation initiation ATPase RLI;
22-75 8.50e-03

ribosome biogenesis/translation initiation ATPase RLI;


Pssm-ID: 184037 [Multi-domain]  Cd Length: 590  Bit Score: 38.64  E-value: 8.50e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 815697066  22 CVKACPteaiRVRNG-----------KAELIEARCIDCGECLRRCGYHAI--VAETDKLEETEQFKY 75
Cdd:PRK13409  21 CIKYCP----VVRTGeetieideddgKPVISEELCIGCGICVKKCPFDAIsiVNLPEELEEEPVHRY 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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