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Conserved domains on  [gi|799124229|ref|WP_045921614|]
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replicative DNA helicase [Bifidobacterium coryneforme]

Protein Classification

replicative DNA helicase( domain architecture ID 11489489)

replicative DNA helicase unwinds the DNA duplex at the chromosome replication fork

EC:  3.6.4.12
Gene Ontology:  GO:0003678|GO:0003677|GO:0005524|GO:0016887|GO:0006269
PubMed:  24373746|10049800|10645945

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DnaB TIGR00665
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ...
 32-463 0e+00

replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]


:

Pssm-ID: 273206 [Multi-domain]  Cd Length: 432  Bit Score: 632.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229   32 PPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGDLDKIGGTDYL 111
Cdd:TIGR00665   1 PPHNIEAEQAVLGAILLDNEAIDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGELEEVGGLAYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  112 HSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSAEGSqAEDIVNMAQAEVYEMSSGKVRQDYEAIGPVVHD 191
Cdd:TIGR00665  81 AELASNVPSAANIEYYAEIVKEKAILRRLIQAGTEIVELAYDPTGD-VEELLDEAEQKIFEIAESRTSKGFKSIKEILKE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  192 TLEQLDKL-QNGYAERGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEMSKTELA 270
Cdd:TIGR00665 160 AVEEIEELyERKGGITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFSLEMSAEQLV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  271 QRIISAETDIPLVALRRADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLKQTNDLKLVVIDYLQLMTS 350
Cdd:TIGR00665 240 MRMLSSESRVDSQKLRTGR-LSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREHGLGLIVIDYLQLMSG 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  351 GKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYDKE-DR 429
Cdd:TIGR00665 319 SGRSENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDEYYNPDsED 398

                         410       420       430
                  ....*....|....*....|....*....|....
gi 799124229  430 PGEADIILAKHRNGPTDTFQLAFLGEKSKFKDMP 463
Cdd:TIGR00665 399 KGIAEIIIAKQRNGPTGTVKLAFLGEYTRFENLA 432
 
Name Accession Description Interval E-value
DnaB TIGR00665
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ...
 32-463 0e+00

replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273206 [Multi-domain]  Cd Length: 432  Bit Score: 632.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229   32 PPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGDLDKIGGTDYL 111
Cdd:TIGR00665   1 PPHNIEAEQAVLGAILLDNEAIDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGELEEVGGLAYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  112 HSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSAEGSqAEDIVNMAQAEVYEMSSGKVRQDYEAIGPVVHD 191
Cdd:TIGR00665  81 AELASNVPSAANIEYYAEIVKEKAILRRLIQAGTEIVELAYDPTGD-VEELLDEAEQKIFEIAESRTSKGFKSIKEILKE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  192 TLEQLDKL-QNGYAERGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEMSKTELA 270
Cdd:TIGR00665 160 AVEEIEELyERKGGITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFSLEMSAEQLV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  271 QRIISAETDIPLVALRRADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLKQTNDLKLVVIDYLQLMTS 350
Cdd:TIGR00665 240 MRMLSSESRVDSQKLRTGR-LSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREHGLGLIVIDYLQLMSG 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  351 GKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYDKE-DR 429
Cdd:TIGR00665 319 SGRSENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDEYYNPDsED 398

                         410       420       430
                  ....*....|....*....|....*....|....
gi 799124229  430 PGEADIILAKHRNGPTDTFQLAFLGEKSKFKDMP 463
Cdd:TIGR00665 399 KGIAEIIIAKQRNGPTGTVKLAFLGEYTRFENLA 432
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
37-462 0e+00

Replicative DNA helicase [Replication, recombination and repair];


Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 616.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  37 DAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGDLDKIGGTDYLHSLVA 116
Cdd:COG0305    3 EAEQAVLGALLLDNDALDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGELEEVGGAAYLAELAE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 117 SVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSAEGSqAEDIVNMAQAEVYEMSSGKVRQDYEAIGPVVHDTLEQL 196
Cdd:COG0305   83 NVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDEDED-VDELLDEAEQKIFEIAEKRSSKGFVSISDILKEALERI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 197 DKL-QNGYAERGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEMSKTELAQRIIS 275
Cdd:COG0305  162 EELyKNGGGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKEGKPVAIFSLEMSAEQLVMRLLS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 276 AETDIPLVALRRADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLKQTNDLKLVVIDYLQLMTSGKRVE 355
Cdd:COG0305  242 SEARIDSSKLRTGK-LSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHGLGLIVIDYLQLMSGSGRSE 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 356 SRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYDKE-DRPGEAD 434
Cdd:COG0305  321 NRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDEYYNPDsEDKGIAE 400

                        410       420
                 ....*....|....*....|....*...
gi 799124229 435 IILAKHRNGPTDTFQLAFLGEKSKFKDM 462
Cdd:COG0305  401 IIIAKQRNGPTGTVKLAFDGEYTRFENL 428
PRK05636 PRK05636
replicative DNA helicase; Provisional
 12-465 0e+00

replicative DNA helicase; Provisional


Pssm-ID: 180177 [Multi-domain]  Cd Length: 505  Bit Score: 556.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  12 PEQRPPREDGGSRDVIFDRVPPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVL 91
Cdd:PRK05636  50 GDRRGFKRREESREYRDFRQPPYDNEAEQGVLGAMLLSPDTVIDIVEVLTPEDFYRPAHQLIFQAIIDLFSDNKEIDPVI 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  92 VANELLKSGDLDKIGGTDYLHSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSA-EGSQAEDIVNMAQAEV 170
Cdd:PRK05636 130 VAGRLDRTNDLERVGGAPYLHTLIQSVPTAANARYYAEIVSEKAVLRRLVDAGTRVVQLGYEGdEGAEIDSVIDRAQQEV 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 171 YEMSSGKVRQDYEAIGPVVHDTLEQLDKLQ-NGYAERGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAA 249
Cdd:PRK05636 210 FAVSQKNQSEDYAVLADILDPTMDELEMLSsQGGIATGIPTGFKDLDDLTNGLRGGQMIIVAARPGVGKSTLALDFMRSA 289

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 250 ALHNNLTTVVFSLEMSKTELAQRIISAETDIPLVALR--RADDitpERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAK 327
Cdd:PRK05636 290 SIKHNKASVIFSLEMSKSEIVMRLLSAEAEVRLSDMRggKMDE---DAWEKLVQRLGKIAQAPIFIDDSANLTMMEIRSK 366

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 328 CRRLKQTNDLKLVVIDYLQLMTSGKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGS 407
Cdd:PRK05636 367 ARRLKQKHDLKLIVVDYLQLMSSGKRVESRQQEVSEFSRQLKLLAKELDVPLIAISQLNRGPESRTDKRPQLADLRESGS 446

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 799124229 408 IEQDADAVFLVHRPDFYDKED-RPGEADIILAKHRNGPTDTFQLAFLGEKSKFKDMPQD 465
Cdd:PRK05636 447 LEQDADMVMLLYRPDSQDKDDeRAGEADIILAKHRGGPIDTVQVAHQLHYSRFVDMARG 505
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 207-461 3.85e-150

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 427.60  E-value: 3.85e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  207 GVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEMSKTELAQRIISAETDIPLVALR 286
Cdd:pfam03796   1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  287 RADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLKQTNDLKLVVIDYLQLMTSGKRVESRQQEVSDFSR 366
Cdd:pfam03796  81 TGQ-LTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHGLGLIVIDYLQLMSGGSRGENRQQEISEISR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  367 ALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYDKEDRPGEADIILAKHRNGPTD 446
Cdd:pfam03796 160 SLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEPEGKAEIIIAKQRNGPTG 239

                         250
                  ....*....|....*
gi 799124229  447 TFQLAFLGEKSKFKD 461
Cdd:pfam03796 240 TVKLAFLGEYTRFEN 254
DnaB_C cd00984
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ...
 207-461 2.66e-131

C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 410864 [Multi-domain]  Cd Length: 256  Bit Score: 379.93  E-value: 2.66e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 207 GVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEMSKTELAQRIISAETDIPLVALR 286
Cdd:cd00984    1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 287 RADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLKQTN-DLKLVVIDYLQLMTSGKRVESRQQEVSDFS 365
Cdd:cd00984   81 TGR-LDDEDWERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHgGLGLIVIDYLQLIRGSKRAENRQQEVAEIS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 366 RALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYDKE-DRPGEADIILAKHRNGP 444
Cdd:cd00984  160 RSLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDsEDKGIAEIIIAKNRNGP 239

                        250
                 ....*....|....*..
gi 799124229 445 TDTFQLAFLGEKSKFKD 461
Cdd:cd00984  240 TGTVYLAFNPEYTRFTD 256
 
Name Accession Description Interval E-value
DnaB TIGR00665
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ...
 32-463 0e+00

replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273206 [Multi-domain]  Cd Length: 432  Bit Score: 632.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229   32 PPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGDLDKIGGTDYL 111
Cdd:TIGR00665   1 PPHNIEAEQAVLGAILLDNEAIDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGELEEVGGLAYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  112 HSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSAEGSqAEDIVNMAQAEVYEMSSGKVRQDYEAIGPVVHD 191
Cdd:TIGR00665  81 AELASNVPSAANIEYYAEIVKEKAILRRLIQAGTEIVELAYDPTGD-VEELLDEAEQKIFEIAESRTSKGFKSIKEILKE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  192 TLEQLDKL-QNGYAERGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEMSKTELA 270
Cdd:TIGR00665 160 AVEEIEELyERKGGITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFSLEMSAEQLV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  271 QRIISAETDIPLVALRRADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLKQTNDLKLVVIDYLQLMTS 350
Cdd:TIGR00665 240 MRMLSSESRVDSQKLRTGR-LSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREHGLGLIVIDYLQLMSG 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  351 GKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYDKE-DR 429
Cdd:TIGR00665 319 SGRSENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDEYYNPDsED 398

                         410       420       430
                  ....*....|....*....|....*....|....
gi 799124229  430 PGEADIILAKHRNGPTDTFQLAFLGEKSKFKDMP 463
Cdd:TIGR00665 399 KGIAEIIIAKQRNGPTGTVKLAFLGEYTRFENLA 432
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
37-462 0e+00

Replicative DNA helicase [Replication, recombination and repair];


Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 616.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  37 DAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGDLDKIGGTDYLHSLVA 116
Cdd:COG0305    3 EAEQAVLGALLLDNDALDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGELEEVGGAAYLAELAE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 117 SVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSAEGSqAEDIVNMAQAEVYEMSSGKVRQDYEAIGPVVHDTLEQL 196
Cdd:COG0305   83 NVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDEDED-VDELLDEAEQKIFEIAEKRSSKGFVSISDILKEALERI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 197 DKL-QNGYAERGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEMSKTELAQRIIS 275
Cdd:COG0305  162 EELyKNGGGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKEGKPVAIFSLEMSAEQLVMRLLS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 276 AETDIPLVALRRADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLKQTNDLKLVVIDYLQLMTSGKRVE 355
Cdd:COG0305  242 SEARIDSSKLRTGK-LSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHGLGLIVIDYLQLMSGSGRSE 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 356 SRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYDKE-DRPGEAD 434
Cdd:COG0305  321 NRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDEYYNPDsEDKGIAE 400

                        410       420
                 ....*....|....*....|....*...
gi 799124229 435 IILAKHRNGPTDTFQLAFLGEKSKFKDM 462
Cdd:COG0305  401 IIIAKQRNGPTGTVKLAFDGEYTRFENL 428
PRK05636 PRK05636
replicative DNA helicase; Provisional
 12-465 0e+00

replicative DNA helicase; Provisional


Pssm-ID: 180177 [Multi-domain]  Cd Length: 505  Bit Score: 556.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  12 PEQRPPREDGGSRDVIFDRVPPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVL 91
Cdd:PRK05636  50 GDRRGFKRREESREYRDFRQPPYDNEAEQGVLGAMLLSPDTVIDIVEVLTPEDFYRPAHQLIFQAIIDLFSDNKEIDPVI 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  92 VANELLKSGDLDKIGGTDYLHSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSA-EGSQAEDIVNMAQAEV 170
Cdd:PRK05636 130 VAGRLDRTNDLERVGGAPYLHTLIQSVPTAANARYYAEIVSEKAVLRRLVDAGTRVVQLGYEGdEGAEIDSVIDRAQQEV 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 171 YEMSSGKVRQDYEAIGPVVHDTLEQLDKLQ-NGYAERGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAA 249
Cdd:PRK05636 210 FAVSQKNQSEDYAVLADILDPTMDELEMLSsQGGIATGIPTGFKDLDDLTNGLRGGQMIIVAARPGVGKSTLALDFMRSA 289

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 250 ALHNNLTTVVFSLEMSKTELAQRIISAETDIPLVALR--RADDitpERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAK 327
Cdd:PRK05636 290 SIKHNKASVIFSLEMSKSEIVMRLLSAEAEVRLSDMRggKMDE---DAWEKLVQRLGKIAQAPIFIDDSANLTMMEIRSK 366

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 328 CRRLKQTNDLKLVVIDYLQLMTSGKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGS 407
Cdd:PRK05636 367 ARRLKQKHDLKLIVVDYLQLMSSGKRVESRQQEVSEFSRQLKLLAKELDVPLIAISQLNRGPESRTDKRPQLADLRESGS 446

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 799124229 408 IEQDADAVFLVHRPDFYDKED-RPGEADIILAKHRNGPTDTFQLAFLGEKSKFKDMPQD 465
Cdd:PRK05636 447 LEQDADMVMLLYRPDSQDKDDeRAGEADIILAKHRGGPIDTVQVAHQLHYSRFVDMARG 505
PRK07773 PRK07773
replicative DNA helicase; Validated
 13-411 1.56e-171

replicative DNA helicase; Validated


Pssm-ID: 236093 [Multi-domain]  Cd Length: 886  Bit Score: 505.05  E-value: 1.56e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  13 EQRPPREDGGSRDVIFDRVPPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLV 92
Cdd:PRK07773   5 DDLAPGMDSSPPSEDYGRQPPQDLAAEQSVLGGMLLSKEAIARVLERLRPGAFYRPAHQNIYDAILDLYGRGEPADLVTV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  93 ANELLKSGDLDKIGGTDYLHSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYsAEGSQAEDIVNMAQAEVYE 172
Cdd:PRK07773  85 AAELDRRGLLERIGGAPYLHTLISTVPTAANADYYARIVAEKALLRRLIEAGTRIVQYGY-AEGADVAEVVDRAQAEIYD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 173 MSSGKVRQDYEAIGPVVHDTLEQLDKLQN-GYAERGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAAL 251
Cdd:PRK07773 164 VTDRRLSEDFVALEDLLQPTFDEIDAIASsGGLARGVPTGFTELDAMTNGLHPGQLIIVAARPSMGKTTFGLDFARNCAI 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 252 HNNLTTVVFSLEMSKTELAQRIISAETDIPLVALRRADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRL 331
Cdd:PRK07773 244 RHRLAVAIFSLEMSKEQLVMRLLSAEAKIKLSDMRSGR-MSDDDWTRLARAMGEISEAPIFIDDTPNLTVMEIRAKARRL 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 332 KQTNDLKLVVIDYLQLMTSGKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQD 411
Cdd:PRK07773 323 RQEANLGLIVVDYLQLMTSGKKYENRQQEVSEISRHLKLLAKELEVPVVALSQLSRGVEQRTDKRPMLSDLRESGCLTGD 402
PRK05748 PRK05748
replicative DNA helicase; Provisional
 25-468 8.32e-170

replicative DNA helicase; Provisional


Pssm-ID: 180232 [Multi-domain]  Cd Length: 448  Bit Score: 485.23  E-value: 8.32e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  25 DVIFDRVPPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGDLDK 104
Cdd:PRK05748   3 EVAALRVPPQSIEAEQAVLGAIFLDPDALITVSEYLSPDDFYRHAHRLIFRAMLKLSDRGEPIDVVTVTEILDDQGDLEE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 105 IGGTDYLHSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSAEGsQAEDIVNMAQAEVYEMSSGKVRQDYEA 184
Cdd:PRK05748  83 VGGLSYLAELANSVPTAANIEYYAKIVAEKAMLRRLIRTATEIANDAYEPED-DADEILDEAEKKIFEVSERRNKSGFKN 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 185 IGPVVHDTLEQLDKLQNGYAE-RGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLE 263
Cdd:PRK05748 162 IKDVLVKAYDRIEMLHNQTGDiTGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVATKTDKNVAIFSLE 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 264 MSKTELAQRIISAETDIPLVALrRADDITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLKQ-TNDLKLVVI 342
Cdd:PRK05748 242 MGAESLVMRMLCAEGNIDAQRL-RTGQLTDDDWPKLTIAMGSLSDAPIYIDDTPGIKVTEIRARCRRLAQeHGGLGLILI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 343 DYLQLMT-SGKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRP 421
Cdd:PRK05748 321 DYLQLIQgSGRSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFLYRD 400

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 799124229 422 DFYDKEDRP-GEADIILAKHRNGPTDTFQLAFLGEKSKFKDMPQDYQQ 468
Cdd:PRK05748 401 DYYDEETENkNTIEIIIAKQRNGPVGTVELAFQKEYNKFVNLARREED 448
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 207-461 3.85e-150

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 427.60  E-value: 3.85e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  207 GVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEMSKTELAQRIISAETDIPLVALR 286
Cdd:pfam03796   1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  287 RADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLKQTNDLKLVVIDYLQLMTSGKRVESRQQEVSDFSR 366
Cdd:pfam03796  81 TGQ-LTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHGLGLIVIDYLQLMSGGSRGENRQQEISEISR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  367 ALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYDKEDRPGEADIILAKHRNGPTD 446
Cdd:pfam03796 160 SLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEPEGKAEIIIAKQRNGPTG 239

                         250
                  ....*....|....*
gi 799124229  447 TFQLAFLGEKSKFKD 461
Cdd:pfam03796 240 TVKLAFLGEYTRFEN 254
PRK05595 PRK05595
replicative DNA helicase; Provisional
 30-468 1.64e-143

replicative DNA helicase; Provisional


Pssm-ID: 235525 [Multi-domain]  Cd Length: 444  Bit Score: 418.08  E-value: 1.64e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  30 RVPPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVAnELLKSGD-LDKIGGT 108
Cdd:PRK05595   6 RSLPQSIEAEQSVLGAMIIDKTSIAEAAEVLKSEDFYRDSHKVIFSAIIELYQKDIAVDMLTLT-ENLKSTDkLEAAGGV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 109 DYLHSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSAEgSQAEDIVNMAQAEVYEMSSGKVRQDYEAIGPV 188
Cdd:PRK05595  85 TYITELSNSIVSTANIQSYIKIVKDKSTLRRLIKSSTEIIENSYNNQ-DDVEKVIDSAEKKIFDISEKRTTSDFEPLSNV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 189 VHDTLEQLDKLQNGYAE-RGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEMSKT 267
Cdd:PRK05595 164 LERGFEQIENLFNNKGEtTGVASGFRELDAKTSGFQKGDMILIAARPSMGKTTFALNIAEYAALREGKSVAIFSLEMSKE 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 268 ELAQRIISAETDIPLVALRRADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLKQTNDLKLVVIDYLQL 347
Cdd:PRK05595 244 QLAYKLLCSEANVDMLRLRTGN-LEDKDWENIARASGPLAAAKIFIDDTAGVSVMEMRSKCRRLKIEHGIDMILIDYLQL 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 348 MTSGKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYDKE 427
Cdd:PRK05595 323 MSGGKGSESRQQEVSEISRSIKALAKEMECPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADVVMFLYRDEYYNKE 402

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 799124229 428 -DRPGEADIILAKHRNGPTDTFQLAFLGEKSKFKDMPQDYQQ 468
Cdd:PRK05595 403 tEDKNVAECIIAKQRNGPTGTVKLAWLGQYSKFGNLDVIHQE 444
PRK08760 PRK08760
replicative DNA helicase; Provisional
 30-465 1.33e-132

replicative DNA helicase; Provisional


Pssm-ID: 181547 [Multi-domain]  Cd Length: 476  Bit Score: 391.59  E-value: 1.33e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  30 RVPPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGDLDKIGGTD 109
Cdd:PRK08760  31 RVPPHSVEAEQAVLGGLMLAPDALDRVNDQLTENDFYRRDHRLIYRAIRELSEKDRPFDAVTLGEWFESQGKLEQVGDGA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 110 YLHSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSAEGSQAEDIVNMAQAEVYEMSS--GKVRQDYEAIGP 187
Cdd:PRK08760 111 YLIELASTTPSAANIAAYAEIVRDKAVLRQLIEVGTTIVNDGFQPEGRESIELLASAEKAVFKIAEagARGRTDFVAMPG 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 188 VVHDTLEQL-DKLQNGYAERGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEMSK 266
Cdd:PRK08760 191 ALKDAFEELrNRFENGGNITGLPTGYNDFDAMTAGLQPTDLIILAARPAMGKTTFALNIAEYAAIKSKKGVAVFSMEMSA 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 267 TELAQRIISAETDIPLVALRRADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLKQTNDLKLVVIDYLQ 346
Cdd:PRK08760 271 SQLAMRLISSNGRINAQRLRTGA-LEDEDWARVTGAIKMLKETKIFIDDTPGVSPEVLRSKCRRLKREHDLGLIVIDYLQ 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 347 LMTSGKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYDK 426
Cdd:PRK08760 350 LMSVPGNSENRATEISEISRSLKGLAKELNVPVIALSQLNRSLETRTDKRPVMADLRESGAIEQDADMIVFIYRDDYYNK 429

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 799124229 427 EDRP--GEADIILAKHRNGPTDTFQLAFLGEKSKFKDMPQD 465
Cdd:PRK08760 430 ENSPdkGLAEIIIGKHRGGPTGSCKLKFFGEYTRFDNLAHD 470
DnaB_C cd00984
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ...
 207-461 2.66e-131

C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 410864 [Multi-domain]  Cd Length: 256  Bit Score: 379.93  E-value: 2.66e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 207 GVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEMSKTELAQRIISAETDIPLVALR 286
Cdd:cd00984    1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 287 RADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLKQTN-DLKLVVIDYLQLMTSGKRVESRQQEVSDFS 365
Cdd:cd00984   81 TGR-LDDEDWERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHgGLGLIVIDYLQLIRGSKRAENRQQEVAEIS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 366 RALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYDKE-DRPGEADIILAKHRNGP 444
Cdd:cd00984  160 RSLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDsEDKGIAEIIIAKNRNGP 239

                        250
                 ....*....|....*..
gi 799124229 445 TDTFQLAFLGEKSKFKD 461
Cdd:cd00984  240 TGTVYLAFNPEYTRFTD 256
phage_DnaB TIGR03600
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or ...
 37-452 1.69e-129

phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or prophage-region) homologs of the bacterial homohexameric replicative helicase DnaB. Some phage may rely on host DnaB, while others encode their own verions. This model describes the largest phage-specific clade among the close homologs of DnaB, but there are, or course, other DnaB homologs from phage that fall outside the scope of this model. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 274672 [Multi-domain]  Cd Length: 420  Bit Score: 381.75  E-value: 1.69e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229   37 DAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGDLDKIGGTDYLHSLVA 116
Cdd:TIGR03600   3 EAEQAVLGGLLLDNDFIERVMAILKPEHFYSQDHRIIFEAMLDMFAENRPVDPLTLADKLEAEGEAEKVGGLAYLAEISN 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  117 SVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSAEGSQAEDIVNMAQAEVYE--MSSGkVRQDYEAIGPVVHDTLE 194
Cdd:TIGR03600  83 NTPSAANISSYARIVREKAKERKLIAACQRIITLACSPDGGTAEQKVEEAQAALLAltMSDG-QEDGFVTFGEVLEDVVR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  195 QLDK-LQNGYAERGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEMSKTELAQRI 273
Cdd:TIGR03600 162 DLDKrFNPKGELTGLSTGLPKLDRLTNGLVKGDLIVIGARPSMGKTTLALNIAENVALREGKPVLFFSLEMSAEQLGERL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  274 ISAETDIPLVALRRADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLK-QTNDLKLVVIDYLQLMTsGK 352
Cdd:TIGR03600 242 LASKSGINTGNIRTGR-FNDSEFNRLLNAVDRLSEKDLYIDDTGGLTVAQIRSIARRIKrKKGGLDLIVVDYIQLMA-PA 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  353 RVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYD-KEDRPG 431
Cdd:TIGR03600 320 RGRDRNEELGGISRGLKALAKELDVPVVLLAQLNRGSEKRTDKRPIMSDLRDSGAIEQDADVIGLIHREGYYDaREPPAG 399

                         410       420
                  ....*....|....*....|.
gi 799124229  432 EADIILAKHRNGPTDTFQLAF 452
Cdd:TIGR03600 400 IAELILAKNRHGPTGTVELLF 420
PRK09165 PRK09165
replicative DNA helicase; Provisional
 30-469 8.68e-128

replicative DNA helicase; Provisional


Pssm-ID: 181676 [Multi-domain]  Cd Length: 497  Bit Score: 380.00  E-value: 8.68e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  30 RVPPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGDLDKIGGTD 109
Cdd:PRK09165  19 RELPHNIEAEQALLGAILINNRALDRVSDFLKPEHFFEPLHQRIYEAIAKIIRKGKLATPVTLKTFLENDEALGELGGVQ 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 110 YLHSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSA-EGSQAEDIVNMAQAEVYEM-SSGKVRQDYEAIGP 187
Cdd:PRK09165  99 YLAKLATEAVTIINARDYGRIIYDLALRRELINIGEDVVNNAYDApVDVAPQEQIEDAEQKLYELaETGRYEGGFQSFGT 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 188 VVHDTLEQLDK-LQNGYAERGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLG--IDFARAAALHNNLTT------- 257
Cdd:PRK09165 179 AITEAVDMANAaFKRDGHLSGISTGLRDLDSKLGGLHPSDLIILAGRPSMGKTALAtnIAFNAAKAYRREAQPdgskkav 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 258 ---VV--FSLEMSKTELAQRIISAETDIPLVALRRADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLK 332
Cdd:PRK09165 259 nggVVgfFSLEMSAEQLATRILSEQSEISSSKIRRGK-ISEEDFEKLVDASQELQKLPLYIDDTPALSISQLRARARRLK 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 333 QTNDLKLVVIDYLQLMT-SGKRV-ESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQ 410
Cdd:PRK09165 338 RQHGLDLLVVDYLQLIRgSSKRSsDNRVQEISEITQGLKALAKELNIPVIALSQLSRQVEQRDDKRPQLSDLRESGSIEQ 417

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 799124229 411 DADAVFLVHRPDFYDKEDRPGE------------------ADIILAKHRNGPTDTFQLAFLGEKSKFKDMPQDYQQG 469
Cdd:PRK09165 418 DADVVMFVYREEYYLKRKEPREgtpkheewqekmekvhnkAEVIIAKQRHGPTGTVKLAFESEFTRFGDLADRSQLP 494
PRK08506 PRK08506
replicative DNA helicase; Provisional
 34-467 5.71e-121

replicative DNA helicase; Provisional


Pssm-ID: 236278 [Multi-domain]  Cd Length: 472  Bit Score: 361.64  E-value: 5.71e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  34 HDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGDLDKiggtDYLHS 113
Cdd:PRK08506   5 YDLDIERAVLSSILFSPDKFEEIASVLEPKDFYLPAHQDIFEAMLKLHNEDEPIDEEFIRKKLPKDKKIDE----EILLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 114 LVASVPTAaNATYYAEIVHQRAILRNVIAAGTKIAQlgYSAEGSQA-EDIVNMAQAEVYEMSSGKVRQDYEAIGPVVHDT 192
Cdd:PRK08506  81 ILATNPID-NIEAYVEEIKEKSIKRELLSLANTIPE--QAVEEDQKsSDILDEVERELYSITNGSNSEDFKDSKEVIEST 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 193 LEQLDKLQN-GYAE-RGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAaLHNNLTTVVFSLEMSKTELA 270
Cdd:PRK08506 158 MEHIKKQKRlGNKDiIGLDTGFVELNKMTKGFNKGDLIIIAARPSMGKTTLCLNMALKA-LNQDKGVAFFSLEMPAEQLM 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 271 QRIISAETDIPLVALRRADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLK-QTNDLKLVVIDYLQLMT 349
Cdd:PRK08506 237 LRMLSAKTSIPLQNLRTGD-LDDDEWERLSDACDELSKKKLFVYDSGYVNIHQVRAQLRKLKsQHPEIGLAVIDYLQLMS 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 350 SGKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFY----- 424
Cdd:PRK08506 316 GSGNFKDRHLQISEISRGLKLLARELDIPIIALSQLNRSLESRADKRPMLSDLRESGAIEQDADIILFVYRDDVYkeree 395

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 799124229 425 -DKEDRPG-----------------EADIILAKHRNGPTDTFQLAFLGEKSKFKDMPQDYQ 467
Cdd:PRK08506 396 kEKEKKAKkegkeerrihfqnksieEAEIIIGKNRNGPTGTVKLRFQKEFTRFVDKPIESH 456
PRK07004 PRK07004
replicative DNA helicase; Provisional
 30-459 1.36e-120

replicative DNA helicase; Provisional


Pssm-ID: 235907 [Multi-domain]  Cd Length: 460  Bit Score: 360.38  E-value: 1.36e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  30 RVPPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGDLDKIGGTD 109
Cdd:PRK07004  13 KVPPHSIEAEQSVLGGLLLDNAAWDRIADFLSQSDFYRYDHRIIFEHIGRLIAATRPADVITVYEALTTSGKAEEVGGLA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 110 YLHSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSAEGSQAEDIVNMAQAEVYEMSSGKVR--QDYEAIGP 187
Cdd:PRK07004  93 YLNALAQNTPSAANIRRYAEIVRDRAVLRRLVSVADEISADAFNPQGKEVRQLLDEAESKVFSIAEEGARgtQGFLEIGP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 188 VVHDTLEQLDKLQNGYAER---GVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEM 264
Cdd:PRK07004 173 LLTQVVERIDTLYHTANPSdvtGTPTGFVDLDRMTSGMHGGELIIVAGRPSMGKTAFSMNIGEYVAVEYGLPVAVFSMEM 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 265 SKTELAQRIISAETDIPLVALRRADdITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRL-KQTNDLKLVVID 343
Cdd:PRK07004 253 PGTQLAMRMLGSVGRLDQHRMRTGR-LTDEDWPKLTHAVQKMSEAQLFIDETGGLNPMELRSRARRLaRQCGKLGLIIID 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 344 YLQLMTSGKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDF 423
Cdd:PRK07004 332 YLQLMSGSSQGENRATEISEISRSLKSLAKELDVPVIALSQLNRGLEQRPNKRPVMSDLRESGAIEQDADVILFIYRDEV 411

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 799124229 424 Y--DKEDRpGEADIILAKHRNGPTDTFQLAFLGEKSKF 459
Cdd:PRK07004 412 YnpDSPDK-GTAEIIIGKQRNGPIGPVRLTFLGQYTKF 448
PRK06904 PRK06904
replicative DNA helicase; Validated
 10-462 1.99e-112

replicative DNA helicase; Validated


Pssm-ID: 136106 [Multi-domain]  Cd Length: 472  Bit Score: 339.66  E-value: 1.99e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  10 THPEQRPPREdggsRDVIFDRV--PPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPV 87
Cdd:PRK06904   3 TTGSQQSARI----KDKKTAQVliPPHSIEAEQAVLGGIMLDNRHWDSVAERVIADDFYTFEHRIIFQEMELLFRQNTPI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  88 DaVLVANELLKS-GDLDKIGGTDYLHSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSAEGSQAEDIVNMA 166
Cdd:PRK06904  79 D-LLTLDQALKTkGKSDEVGGFAYLAELSNNTPSAANILAYADIVREKAILRELISVGNNIAKNAYSPKGQDIKDILDEA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 167 QAEVYEMSSGKVRQDyEAIGPVVH------DTLEQLDKLQNGYAERGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKST 240
Cdd:PRK06904 158 ERDVFSIAEKRTTAN-EGPQNVINllentiDKIENLAATPTNNGVTGVTTGFTDLDKKTAGLQPSDLIIVAARPSMGKTT 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 241 LGIDFARAAALHNNLTTVVFSLEMSKTELAQRIISAETDIPLVALRRADDITPERWNTLNTFWSKLQEAP-LFLDDSPNM 319
Cdd:PRK06904 237 FAMNLCENAAMASEKPVLVFSLEMPAEQIMMRMLASLSRVDQTKIRTGQNLDQQDWAKISSTVGMFKQKPnLYIDDSSGL 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 320 SLMEIRAKCRRLKQTND-LKLVVIDYLQLMTSGKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPM 398
Cdd:PRK06904 317 TPTELRSRARRVYRENGgLSLIMVDYLQLMRAPGFEDNRTLEIAEISRSLKALAKELKVPVVALSQLNRTLENRGDKRPV 396

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 799124229 399 LSDLRESGSIEQDADAVFLVHRPDFYDK--EDRPGEADIILAKHRNGPTDTFQLAFLGEKSKFKDM 462
Cdd:PRK06904 397 NSDLRESGSIEQDADLIMFIYRDEVYNEttEDNKGVAEIIIGKQRNGPIGRVRLAFQGQYSRFDNL 462
PRK08840 PRK08840
replicative DNA helicase; Provisional
 13-461 1.54e-108

replicative DNA helicase; Provisional


Pssm-ID: 181562 [Multi-domain]  Cd Length: 464  Bit Score: 329.64  E-value: 1.54e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  13 EQRPPREDGGSRDVIfdRVPPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLV 92
Cdd:PRK08840   3 DNRNRKIPDAQVDAI--KVPPHSLEAEQSVIGGLLLDNERWDTVAEKVVASDFYSRPHRLIFEGVKSILEAGKPLDLITL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  93 ANELLKSGDLDKIGGTDYLHSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSAEGSQAEDIVNMAQAEVYE 172
Cdd:PRK08840  81 SEHLERREQLEDVGGFAYLADLAKNTPSAANINAYADIVAERALVRNLIGVANEIADAGYDPQGRTSEDLLDMAESKVFA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 173 MSSGKVRQDY--EAIGPVVHDTLEQLDKL----QNGYAerGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFA 246
Cdd:PRK08840 161 IAEARTSENEgpQNVDSILEKTLERIELLyktpQDGVT--GVDTGFTDLNKKTAGLQGSDLIIVAARPSMGKTTFAMNLC 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 247 RAAALHNNLTTVVFSLEMSKTELAQRIISAETDIPLVALR--RADDitpERWNTLNTFWSKLQEAP-LFLDDSPNMSLME 323
Cdd:PRK08840 239 ENAAMDQDKPVLIFSLEMPAEQLMMRMLASLSRVDQTKIRtgQLDD---EDWARISSTMGILMEKKnMYIDDSSGLTPTE 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 324 IRAKCRRLKQTND-LKLVVIDYLQLMTSGKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDL 402
Cdd:PRK08840 316 VRSRARRIAREHGgLSMIMVDYLQLMRVPALSDNRTLEIAEISRSLKALAKELNVPVVALSQLNRSLEQRADKRPVNSDL 395

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 403 RESGSIEQDADAVFLVHRPDFYDKED-RPGEADIILAKHRNGPTDTFQLAFLGEKSKFKD 461
Cdd:PRK08840 396 RESGSIEQDADLIMFIYRDEVYNPDSpLKGTAEIIIGKQRNGPIGSVRLTFQGQYSRFDN 455
PRK08006 PRK08006
replicative DNA helicase DnaB;
1-461 3.02e-108

replicative DNA helicase DnaB;


Pssm-ID: 181193 [Multi-domain]  Cd Length: 471  Bit Score: 328.89  E-value: 3.02e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229   1 MVSENSTDYTHPEQRPPredggSRDVIFDRVPPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITL 80
Cdd:PRK08006   1 MAGNKPFNKQQAEPRER-----DPQVAGLKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVADDFYTRPHRHIFTEMARL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  81 FSASQPVDAVLVANELLKSGDLDKIGGTDYLHSLVASVPTAANATYYAEIVHQRAILRNVIAAGTKIAQLGYSAEGSQAE 160
Cdd:PRK08006  76 QESGSPIDLITLAESLERQGQLDSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIADAGYDPQGRTSE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 161 DIVNMAQAEVYEMSSGKVRQDY--EAIGPVVHDTLEQLDKL--QNGYAERGVPTGFKSIDDVTQGLQPGQMVVVAGRPAM 236
Cdd:PRK08006 156 DLLDLAESRVFQIAESRANKDEgpKNIADILDATVARIEQLfqQPHDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSM 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 237 GKSTLGIDFARAAALHNNLTTVVFSLEMSKTELAQRIISAETDIPLVALR--RADDitpERWNTLN-TFWSKLQEAPLFL 313
Cdd:PRK08006 236 GKTTFAMNLCENAAMLQDKPVLIFSLEMPGEQIMMRMLASLSRVDQTRIRtgQLDD---EDWARISgTMGILLEKRNMYI 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 314 DDSPNMSLMEIRAKCRRLKQTND-LKLVVIDYLQLMTSGKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMR 392
Cdd:PRK08006 313 DDSSGLTPTEVRSRARRIFREHGgLSLIMIDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELQVPVVALSQLNRSLEQR 392

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 393 NDKKPMLSDLRESGSIEQDADAVFLVHRPDFY-DKEDRPGEADIILAKHRNGPTDTFQLAFLGEKSKFKD 461
Cdd:PRK08006 393 ADKRPVNSDLRESGSIEQDADLIMFIYRDEVYhENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDN 462
PRK06321 PRK06321
replicative DNA helicase; Provisional
 31-461 2.76e-95

replicative DNA helicase; Provisional


Pssm-ID: 180528 [Multi-domain]  Cd Length: 472  Bit Score: 295.60  E-value: 2.76e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  31 VPPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGDLDKIGGTDY 110
Cdd:PRK06321  15 SPPNSKESEMIVLGCMLTSVNYLNLAANQLQEDDFYFLEHKIIFRVLQDAFKSDKPIDVHLAGEELKRRNQLNVIGGPSY 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 111 LHSLVASVPTAANATYYAEIVHQRAILRNVIAAgTKIAQLGYSAEGSQAEDIVNMAQAEVYEMSSGKVRQDYEAIGPVVH 190
Cdd:PRK06321  95 LITLAEFAGTSAYIEEYAEIIRSKSILRKMIQT-AKEIEKKALEEPKDVATALDEAQNLLFKISQTTNLAQYVLVADKLK 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 191 DT--------LEQLDKLQNGYAER----------GVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAALH 252
Cdd:PRK06321 174 GLtsskdkpfLLQLQERQEAFQQSaqgdsspmisGIPTHFIDLDKMINGFSPSNLMILAARPAMGKTALALNIAENFCFQ 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 253 NNLTTVVFSLEMSKTELAQRIISAETDIPLVALRrADDITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLK 332
Cdd:PRK06321 254 NRLPVGIFSLEMTVDQLIHRIICSRSEVESKKIS-VGDLSGRDFQRIVSVVNEMQEHTLLIDDQPGLKITDLRARARRMK 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 333 QTNDLKLVVIDYLQLMTSG---KRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIE 409
Cdd:PRK06321 333 ESYDIQFLIIDYLQLLSGSgnlRNSESRQTEISEISRMLKNLARELNIPILCLSQLSRKVEDRANHRPMMSDLRESGSIE 412

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 799124229 410 QDADAVFLVHRPDFYDKEDRPGEADIILAKHRNGPTDTFQLAFLGEKSKFKD 461
Cdd:PRK06321 413 QDSDLVMFLLRREYYDPNDKPGTAELIVAKNRHGSIGSVPLVFEKEFARFRN 464
PRK06749 PRK06749
replicative DNA helicase; Provisional
 37-462 1.50e-82

replicative DNA helicase; Provisional


Pssm-ID: 168658 [Multi-domain]  Cd Length: 428  Bit Score: 261.42  E-value: 1.50e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  37 DAEMAVLGGMLMSKDAIGEVSqmIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGdLDKIGGTDYLHSLVA 116
Cdd:PRK06749   7 EAEKTVLGSLLLDGELIKECR--LTEQYFSMPVHKSIFQLMRKMEDEGQPIDLVTFTSRVDPNF-LKGIGGMEYFIGLMD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 117 SVPTAANATYYAEIVHQRAILRNviaAGTKIAQLGYSAEGSQAEDIVNMAQAEVYEMSSGKVRQDYEaigpvVHDTLEQL 196
Cdd:PRK06749  84 GVPTTSNFSYYEGLVRGAWKMYQ---AGVLGHKMGERLIAEKSEKIIGETITALCELEEKDCVCEFD-----LKDALVDL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 197 -DKLQNGYAE-RGVPTGFKSIDDVTQGLQPGQMVVVAGRPAMGKSTLGIDFARAAAlHNNLTTVVFSLEMSKTELAQRII 274
Cdd:PRK06749 156 yEELHQDAKEiTGIETGYTSLNKMTCGLQEGDFVVLGARPSMGKTAFALNVGLHAA-KSGAAVGLFSLEMSSKQLLKRMA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 275 SAETDIPLVALRRADD-ITPERWNTLNTFWSKLQEAPLFLDDSPNMSLMEIRAKCRRLKQTNDLK--LVVIDYLQLMTSG 351
Cdd:PRK06749 235 SCVGEVSGGRLKNPKHrFAMEDWEKVSKAFAEIGELPLEIYDNAGVTVQDIWMQTRKLKRKHGDKkiLIIVDYLQLITGD 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 352 -KRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYDKEDRP 430
Cdd:PRK06749 315 pKHKGNRFQEISEISRKLKLLARELNVCVVALSQLSRSVESRQDKRPLLSDLRETGQIEQDADVIMLMYREDYYDKETMQ 394

                        410       420       430
                 ....*....|....*....|....*....|...
gi 799124229 431 GE-ADIILAKHRNGPTDTFQLAFLGEKSKFKDM 462
Cdd:PRK06749 395 KEmTEIHVAKHRNGPVGSFKLRFLKEFGRFVEG 427
DnaB pfam00772
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 31-133 8.04e-39

DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity.


Pssm-ID: 395624 [Multi-domain]  Cd Length: 103  Bit Score: 136.21  E-value: 8.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229   31 VPPHDDDAEMAVLGGMLMSKDAIGEVSQMIDVADFYQPKHQTIYEAIITLFSASQPVDAVLVANELLKSGDLDKIGGTDY 110
Cdd:pfam00772   1 VPPHNIEAEQAVLGALLLDPEAIDEVADILKPEDFYDPAHRLIFEAILDLYDKGEPIDPVTVAEELEKKGKLEDVGGIAY 80

                          90       100
                  ....*....|....*....|...
gi 799124229  111 LHSLVASVPTAANATYYAEIVHQ 133
Cdd:pfam00772  81 LAELAANVPSAANIEYYARIVKE 103
PRK07773 PRK07773
replicative DNA helicase; Validated
 407-465 8.29e-19

replicative DNA helicase; Validated


Pssm-ID: 236093 [Multi-domain]  Cd Length: 886  Bit Score: 89.42  E-value: 8.29e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 407 SIEQDADAVFLVHRPDFYDKED-RPGEADIILAKHRNGPTDTFQLAFLGEKSKFKDMPQD 465
Cdd:PRK07773 827 SIEQDADVVILLYRPDYYDRDDpRGGEAEFIVAKHRNGPTGTVTLAFQLHLSRFANLARS 886
RecA-like_Gp4D_helicase cd19483
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the ...
 236-449 3.59e-17

RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the RecA-like domain of the Gp4D fragment of the Gene4 helicase-primase (Gp4) from bacteriophage T7. Gp4D (residues 241-566) is the minimal fragment of the Gp4 that forms hexameric rings, it contains the helicase domain and the linker connecting the helicase and primase domains. Helicases are ring-shaped oligomeric enzymes that unwind DNA at the replication fork; they couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410891 [Multi-domain]  Cd Length: 231  Bit Score: 80.31  E-value: 3.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 236 MGKSTlgidFARAAALHNNLTT----VVFSLEMSKTELAQRIIS--AETDIPLVALRRADDITPERWntlntFWSKLQEA 309
Cdd:cd19483    9 IGKST----IVRELAYHLITEHgekvGIISLEESVEETAKGLAGkhLGKPEPLELPRDDITEEEEDD-----AFDNELGS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 310 P--LFLDDSPNMSLMEIRAKCRRLKQTNDLKLVVIDYLQLMTSGKRVESRQQEVSDFSRALKLLAKELEVPVVALSQLNR 387
Cdd:cd19483   80 GrfFLYDHFGSLDWDNLKEKIRYMVKVLGCKVIVLDHLTILVSGLDSSDERKELDEIMTELAALVKELGVTIILVSHLRR 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 799124229 388 ---GPEMRNDKKPMLSDLRESGSIEQDADAVFLVHRPDFYDKEDRPGEADIILAKHRN----GPTDTFQ 449
Cdd:cd19483  160 pggGKGHEEGGEVSESDLRGSSAIAQLSDYVIGLERNKQADDPVERNTTRVRVLKNRFtgetGIAGTLY 228
PRK05973 PRK05973
replicative DNA helicase; Provisional
 222-403 5.23e-16

replicative DNA helicase; Provisional


Pssm-ID: 168322 [Multi-domain]  Cd Length: 237  Bit Score: 77.38  E-value: 5.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 222 LQPGQMVVVAGRPAMGKSTLGIDFARAAALHNNlTTVVFSLEMSKTELAQRIisaetdiplvalrRADDITPErwntlnt 301
Cdd:PRK05973  61 LKPGDLVLLGARPGHGKTLLGLELAVEAMKSGR-TGVFFTLEYTEQDVRDRL-------------RALGADRA------- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 302 fwsklQEAPLF-LDDSPNMSLMEIrakCRRLKQTNDLKLVVIDYLQLMTSgKRvesRQQEVSDFSRALKLLAKELEVPVV 380
Cdd:PRK05973 120 -----QFADLFeFDTSDAICADYI---IARLASAPRGTLVVIDYLQLLDQ-RR---EKPDLSVQVRALKSFARERGLIIV 187

                        170       180
                 ....*....|....*....|...
gi 799124229 381 ALSQLNRGPEMRNDKKPMLSDLR 403
Cdd:PRK05973 188 FISQIDRSFDPSAKPLPDIRDVR 210
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
208-419 2.01e-11

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 63.40  E-value: 2.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 208 VPTGFKSIDDVTQ-GLQPGQMVVVAGRPAMGKSTLGIDFArAAALHNNLTTVVFSLEMSKTELAQRIisAETDIPLVALR 286
Cdd:COG0467    2 VPTGIPGLDELLGgGLPRGSSTLLSGPPGTGKTTLALQFL-AEGLRRGEKGLYVSFEESPEQLLRRA--ESLGLDLEEYI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 287 RADDITperwntlntfwsklqeaplFLDDSPNM---SLMEIRAKCRRLKQTNDLKLVVID----YLQLMTSgkrvesrQQ 359
Cdd:COG0467   79 ESGLLR-------------------IIDLSPEElglDLEELLARLREAVEEFGAKRVVIDslsgLLLALPD-------PE 132

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 360 EVSDFSRALKLLAKELEVPVVALSQlnrgpemrndkKPMLSDLRESGSIEQDADAVFLVH 419
Cdd:COG0467  133 RLREFLHRLLRYLKKRGVTTLLTSE-----------TGGLEDEATEGGLSYLADGVILLR 181
AAA_25 pfam13481
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.
 228-390 4.99e-10

AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.


Pssm-ID: 463892 [Multi-domain]  Cd Length: 193  Bit Score: 58.93  E-value: 4.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  228 VVVAGRPAMGKSTLGIDFARAAALHN----------NLTTVVFSLEMSKTELAQRIISAETDIPLvalrradditPERWn 297
Cdd:pfam13481  36 GLLAGAPGTGKTTLALDLAAAVATGKpwlggprvpeQGKVLYVSAEGPADELRRRLRAAGADLDL----------PARL- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229  298 tlnTFWSKLQEAPLFLDDSPNMSLME-IRAKCRRLKQTNDLKLVVIDYLQLMTSGkrVESRQQEVSDFSRALKLLAKELE 376
Cdd:pfam13481 105 ---LFLSLVESLPLFFLDRGGPLLDAdVDALEAALEEVEDPDLVVIDPLARALGG--DENSNSDVGRLVKALDRLARRTG 179

                         170
                  ....*....|....
gi 799124229  377 VPVVALSQLNRGPE 390
Cdd:pfam13481 180 ATVLLVHHVGKDGA 193
41 PHA02542
41 helicase; Provisional
 188-422 1.50e-06

41 helicase; Provisional


Pssm-ID: 222864 [Multi-domain]  Cd Length: 473  Bit Score: 50.45  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 188 VVHDTLEQLDKLQNGY--AERGVPTGFKSIDDVTQG-LQPGQMVVVAGRPAMGKSTLGIDFArAAALHNNLTTVVFSLEM 264
Cdd:PHA02542 150 VGHDYFEDYEERYDSYqsKANKIPFKLEILNKITKGgAERKTLNVLLAGVNVGKSLGLCSLA-ADYLQQGYNVLYISMEM 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 265 SKTELAQRIISAETDIPLVALrraDDIT-PERWNTLNTfWSKLQEAPLFLDDSPNMS--LMEIRAKCRRLKQTNDLK--L 339
Cdd:PHA02542 229 AEEVIAKRIDANLLDVSLDDI---DDLSkAEYKAKMEK-LRSKTQGKLIIKQYPTGGahAGHFRALLNELKLKKNFKpdV 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 340 VVIDYLQLMTSgKRVESRQQE----VSDFSRALKLLAKELEVPVVALSQLNRGPEMRNDkkPMLSDLRESGSIEQDADAV 415
Cdd:PHA02542 305 IIVDYLGICAS-SRLRVSSENsytyVKAIAEELRGLAVEHDVVVWTAAQTTRSGWDSSD--VDMSDTAESAGLPATADFM 381


                 ....*..
gi 799124229 416 FLVHRPD 422
Cdd:PHA02542 382 LAVIETE 388
KaiC-like cd01124
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ...
 208-386 5.55e-05

Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410869 [Multi-domain]  Cd Length: 222  Bit Score: 44.18  E-value: 5.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 208 VPTGFKSIDDVTQGLQP-GQMVVVAGRPAMGKSTLGIDFARAAALHNNlTTVVFSLEMSKTELAQRIISAETDipLVALR 286
Cdd:cd01124    1 VKTGIPGLDELLGGGIPkGSVTLLTGGPGTGKTLFGLQFLYAGAKNGE-PGLFFTFEESPERLLRNAKSFGWD--FDEME 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 287 RADDItperwntlntfwsklqeapLFLDDSP----NMSLMEIRAKCRRLKQTNDLKLVVIDYLQLMTSGKRVESRQQEvs 362
Cdd:cd01124   78 DEGKL-------------------IIVDAPPteagRFSLDELLSRILSIIKSFKAKRVVIDSLSGLRRAKEDQMRARR-- 136

                        170       180
                 ....*....|....*....|....
gi 799124229 363 dFSRALKLLAKELEVPVVALSQLN 386
Cdd:cd01124  137 -IVIALLNELRAAGVTTIFTSEMR 159
Rad51B cd19493
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 230-389 3.19e-03

RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410901 [Multi-domain]  Cd Length: 222  Bit Score: 38.84  E-value: 3.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 230 VAGRPAMGKSTLGIDFARAAALHNNL-----------TTVVFSLE------MSKTELAQRIISAETDIPLVALRRADDIT 292
Cdd:cd19493   16 ITGASGSGKTQFALTLASSAAMPARKggldggvlyidTESKFSAErlaeiaEARFPEAFSGFMEENERAEEMLKRVAVVR 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 293 PerwNTLNTFWSKLQEaplfLDDspNMSLMEIRakcrrlkqtndlkLVVIDYLQLM------TSGKRVESRQQEVSDFSR 366
Cdd:cd19493   96 V---TTLAQLLERLPN----LEE--HILSSGVR-------------LVVIDSIAALvrrefgGSDGEVTERHNALAREAS 153

                        170       180
                 ....*....|....*....|...
gi 799124229 367 ALKLLAKELEVPVVALSQLNRGP 389
Cdd:cd19493  154 SLKRLAEEFRIAVLVTNQATTHF 176
RepA_RSF1010_like cd01125
Hexameric Replicative Helicase RepA of plasmid RSF1010 and related proteins; This family ...
 225-434 4.95e-03

Hexameric Replicative Helicase RepA of plasmid RSF1010 and related proteins; This family includes the homo-hexameric replicative helicase RepA encoded by plasmid RSF1010. RSF1010 is found in most Gram-negative bacteria and some Gram-positive bacteria . The RepA protein of Plasmid RSF1010 is a 5'-3' DNA helicase which can utilize ATP, dATP, GTP and dGTP (and CTP and dCTP to a lesser extent).


Pssm-ID: 410870  Cd Length: 238  Bit Score: 38.52  E-value: 4.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 225 GQMVVVAGRPAMGKSTLGIDFARAAAL---------HNNLTTVVFSLEMSKTELAQRIISAETDIPLVALRRADDITPEr 295
Cdd:cd01125    1 GTLGMLVGPPGSGKSFLALDLAVAVATgrdwlgerrVKQGRVVYLAAEDPRDGLRRRLKAIGAHLGDEDAALAENLVIE- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 296 wntlntfwsklqeaPLFLDDSPNMSLMEIRAkcRRLKQTNDLKLVVIDYLQLMTSGKRvESRQQEVSDFSRALKLLAKEL 375
Cdd:cd01125   80 --------------NLRGKPVSIDAEAPELE--RIIEELEGVRLIIIDTLARVLHGGD-ENDAADMGAFVAGLDRIARET 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 799124229 376 EVPVVALSQLNRGPEMrndkkPMLSDLRESGSIEQDADAVFLVHRPDFYDKEDRPGEAD 434
Cdd:cd01125  143 GAAVLLVHHTGKDAAG-----DSQQAARGSSALRGAADAEINLSKMDATEAEKVGLDKD 196
ATPase pfam06745
KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and ...
 208-272 5.28e-03

KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and eukaryotes. More than one copy is sometimes found in each protein. This family includes KaiC, which is one of the Kai proteins among which direct protein-protein association may be a critical process in the generation of circadian rhythms in cyanobacteria.


Pssm-ID: 429095 [Multi-domain]  Cd Length: 231  Bit Score: 38.38  E-value: 5.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 799124229  208 VPTGFKSIDDVTQGLQP-GQMVVVAGRPAMGKSTLGIDFARAAALHNNLTTVVFSLEMSKTELAQR 272
Cdd:pfam06745   1 VKTGIPGLDEILKGGFPeGRVVLITGGPGTGKTIFGLQFLYNGALKYGEPGVFVTLEEPPEDLREN 66
KaiC-like_N cd19488
N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 210-345 8.33e-03

N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410896 [Multi-domain]  Cd Length: 225  Bit Score: 37.71  E-value: 8.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 799124229 210 TGFKSIDDVTQG-LQPGQMVVVAGRPAMGKSTLGIDFARAAAlHNNLTTVVFSLEMSKTELaqRIISAETDIPLVALRRA 288
Cdd:cd19488    3 TGIPGLDDILRGgLPPRRLYLVEGAPGTGKTTLALQFLLEGA-ANGETGLYITLSETEQEL--RAVALSHGWSLDGIHIF 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 799124229 289 DDITPERWNTLNTFWSKLQEAPLFLDDSPNMslmeIRAKCRRLKQTndlkLVVIDYL 345
Cdd:cd19488   80 ELSPSESALDAAQQYTILHPSELELSETTRL----IFERVERLKPS----RVVIDSL 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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