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Conserved domains on  [gi|796853239|ref|WP_045795711|]
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MULTISPECIES: 50S ribosomal protein L3 N(5)-glutamine methyltransferase [Acinetobacter]

Protein Classification

ribosomal protein L3 N(5)-glutamine methyltransferase( domain architecture ID 11497021)

ribosomal protein L3 N(5)-glutamine methyltransferase specifically methylates the 50S ribosomal protein L3 on Gln-150 using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; does not methylate the translation termination release factors RF1 and RF2; belongs to the class I SAM-dependent methyltransferase superfamily

CATH:  2.20.25.110
EC:  2.1.1.298
Gene Ontology:  GO:0008757|GO:0006479|GO:1904047|GO:0018364
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 18-320 1.51e-156

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


:

Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 439.64  E-value: 1.51e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239   18 LVTIRDFIRFGVTALRQYDAHLGQGTEDYFAESSALVLQTLSLDWNADAEILDAKLLPSEKQEFLSLLERRINERTPTSY 97
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239   98 LLNLAYFYGKPFYVDERVLIPRSPIAELIENRFAPYcldengqmgeannnlpanPNPQMPRRILDMCTGSGCIAIALAYA 177
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPW------------------LEPEPVKRILDLCTGSGCIAIACAYA 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  178 FPDAEVDATDISKDALEVAAINTEHHNMQYQVALLESDLFSKIPAEnQYDLIVSNPPYVDAEDMADLPDEFRHEPELALA 257
Cdd:TIGR03533 143 FPEAEVDAVDISPDALAVAEINIERHGLEDRVTLIQSDLFAALPGR-KYDLIVSNPPYVDAEDMADLPAEYHHEPELALA 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 796853239  258 AGQDGLDLVRKMLAQAADYLTEDGLIVIEVGNSEWAMKQNFNTVDFHWLQFQKGGSGIFALTA 320
Cdd:TIGR03533 222 SGEDGLDLVRRILAEAADHLNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
 
Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 18-320 1.51e-156

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 439.64  E-value: 1.51e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239   18 LVTIRDFIRFGVTALRQYDAHLGQGTEDYFAESSALVLQTLSLDWNADAEILDAKLLPSEKQEFLSLLERRINERTPTSY 97
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239   98 LLNLAYFYGKPFYVDERVLIPRSPIAELIENRFAPYcldengqmgeannnlpanPNPQMPRRILDMCTGSGCIAIALAYA 177
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPW------------------LEPEPVKRILDLCTGSGCIAIACAYA 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  178 FPDAEVDATDISKDALEVAAINTEHHNMQYQVALLESDLFSKIPAEnQYDLIVSNPPYVDAEDMADLPDEFRHEPELALA 257
Cdd:TIGR03533 143 FPEAEVDAVDISPDALAVAEINIERHGLEDRVTLIQSDLFAALPGR-KYDLIVSNPPYVDAEDMADLPAEYHHEPELALA 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 796853239  258 AGQDGLDLVRKMLAQAADYLTEDGLIVIEVGNSEWAMKQNFNTVDFHWLQFQKGGSGIFALTA 320
Cdd:TIGR03533 222 SGEDGLDLVRRILAEAADHLNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 20-290 3.32e-96

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 286.28  E-value: 3.32e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  20 TIRDFIRFGVTALRQydahlgQGTEDYFAESSALVLQTLSLDWNADAEILDAKLLPSEKQEFLSLLERRiNERTPTSYLL 99
Cdd:COG2890    2 TIRELLRWAAARLAA------AGVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARR-AAGEPLAYIL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 100 NLAYFYGKPFYVDERVLIPRSPIAELIENRFApyCLDENGqmgeannnlpanpnpqmPRRILDMCTGSGCIAIALAYAFP 179
Cdd:COG2890   75 GEAEFYGLEFKVDPGVLIPRPETEELVELALA--LLPAGA-----------------PPRVLDLGTGSGAIALALAKERP 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 180 DAEVDATDISKDALEVAAINTEHHNMQYQVALLESDLFSKIPAENQYDLIVSNPPYVDAEDMADLPDEFR-HEPELALAA 258
Cdd:COG2890  136 DARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDLFEPLPGDGRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDG 215

                        250       260       270
                 ....*....|....*....|....*....|..
gi 796853239 259 GQDGLDLVRKMLAQAADYLTEDGLIVIEVGNS 290
Cdd:COG2890  216 GEDGLDFYRRIIAQAPRLLKPGGWLLLEIGED 247
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 65-288 4.52e-69

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 216.95  E-value: 4.52e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  65 DAEIL----------------DAKLLPSEKQEFLSLLERRINeRTPTSYLLNLAYFYGKPFYVDERVLIPRsP----IAE 124
Cdd:PRK09328  21 DAELLlahvlglsrtdlllnpEEELTPEELERFRALVARRAA-GEPLQYILGEAEFWGLDFKVSPGVLIPR-PeteeLVE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 125 LIENRFAPYcldengqmgeannnlpanpnpqMPRRILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAAINTEHHN 204
Cdd:PRK09328  99 WALEALLLK----------------------EPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 205 mQYQVALLESDLFSKIPAEnQYDLIVSNPPYVDAEDMADLPDEFR-HEPELALAAGQDGLDLVRKMLAQAADYLTEDGLI 283
Cdd:PRK09328 157 -GARVEFLQGDWFEPLPGG-RFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWL 234


                 ....*
gi 796853239 284 VIEVG 288
Cdd:PRK09328 235 LLEIG 239
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 158-301 3.91e-19

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 83.02  E-value: 3.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  158 RRILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAAINTEHHNMQyQVALLESDLFSKIPaENQYDLIVSNPPyvd 237
Cdd:pfam05175  33 GKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLE-NGEVVASDVYSGVE-DGKFDLIISNPP--- 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 796853239  238 aedmadlpdeFRhepelalAAGQDGLDLVRKMLAQAADYLTEDGLIVIeVGNS----EWAMKQNFNTV 301
Cdd:pfam05175 108 ----------FH-------AGLATTYNVAQRFIADAKRHLRPGGELWI-VANRflgyPPLLEELFGNV 157
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 159-287 5.25e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.98  E-value: 5.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 159 RILDMCTGSGCIAIALAyAFPDAEVDATDISKDALEVAAINTEHHNMQYqVALLESDLFS-KIPAENQYDLIVSNPPYvd 237
Cdd:cd02440    1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKAAAALLADN-VEVLKGDAEElPPEADESFDVIISDPPL-- 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 796853239 238 aedmadlpdefrhepelalaagQDGLDLVRKMLAQAADYLTEDGLIVIEV 287
Cdd:cd02440   77 ----------------------HHLVEDLARFLEEARRLLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 18-320 1.51e-156

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 439.64  E-value: 1.51e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239   18 LVTIRDFIRFGVTALRQYDAHLGQGTEDYFAESSALVLQTLSLDWNADAEILDAKLLPSEKQEFLSLLERRINERTPTSY 97
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239   98 LLNLAYFYGKPFYVDERVLIPRSPIAELIENRFAPYcldengqmgeannnlpanPNPQMPRRILDMCTGSGCIAIALAYA 177
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPW------------------LEPEPVKRILDLCTGSGCIAIACAYA 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  178 FPDAEVDATDISKDALEVAAINTEHHNMQYQVALLESDLFSKIPAEnQYDLIVSNPPYVDAEDMADLPDEFRHEPELALA 257
Cdd:TIGR03533 143 FPEAEVDAVDISPDALAVAEINIERHGLEDRVTLIQSDLFAALPGR-KYDLIVSNPPYVDAEDMADLPAEYHHEPELALA 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 796853239  258 AGQDGLDLVRKMLAQAADYLTEDGLIVIEVGNSEWAMKQNFNTVDFHWLQFQKGGSGIFALTA 320
Cdd:TIGR03533 222 SGEDGLDLVRRILAEAADHLNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 20-290 3.32e-96

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 286.28  E-value: 3.32e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  20 TIRDFIRFGVTALRQydahlgQGTEDYFAESSALVLQTLSLDWNADAEILDAKLLPSEKQEFLSLLERRiNERTPTSYLL 99
Cdd:COG2890    2 TIRELLRWAAARLAA------AGVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARR-AAGEPLAYIL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 100 NLAYFYGKPFYVDERVLIPRSPIAELIENRFApyCLDENGqmgeannnlpanpnpqmPRRILDMCTGSGCIAIALAYAFP 179
Cdd:COG2890   75 GEAEFYGLEFKVDPGVLIPRPETEELVELALA--LLPAGA-----------------PPRVLDLGTGSGAIALALAKERP 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 180 DAEVDATDISKDALEVAAINTEHHNMQYQVALLESDLFSKIPAENQYDLIVSNPPYVDAEDMADLPDEFR-HEPELALAA 258
Cdd:COG2890  136 DARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDLFEPLPGDGRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDG 215

                        250       260       270
                 ....*....|....*....|....*....|..
gi 796853239 259 GQDGLDLVRKMLAQAADYLTEDGLIVIEVGNS 290
Cdd:COG2890  216 GEDGLDFYRRIIAQAPRLLKPGGWLLLEIGED 247
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 19-312 9.05e-85

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 257.28  E-value: 9.05e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239   19 VTIRDFIRFGVTALRQYDAHLGQGTEdyfaessALVLQTLSLDWNADAEI--LDAKLLPSEKQEFLSLLERRINErTPTS 96
Cdd:TIGR00536   1 MTIQEFLRWASSALSRAIARENPWLE-------ALLLLEHDLGRERDLLLafLTEELTPDEKERIFRLVLRRVKG-VPVA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239   97 YLLNLAYFYGKPFYVDERVLIPRSPIAELIENRFAPycLDENGQMgeannnlpanpnpqmpRRILDMCTGSGCIAIALAY 176
Cdd:TIGR00536  73 YLLGSKEFYGLEFFVNEHVLIPRPETEELVEKALAS--LISQPPI----------------LHILDLGTGSGCIALALAY 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  177 AFPDAEVDATDISKDALEVAAINTEHHNMQYQVALLESDLFSKIPAEnQYDLIVSNPPYVDAEDMADLPDEFRHEPELAL 256
Cdd:TIGR00536 135 EFPNAEVIAVDISPDALAVAEENAEKNQLEHRVEFIQSNLFEPLAGQ-KIDIIVSNPPYIDEEDLADLPNVVRFEPLLAL 213

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 796853239  257 AAGQDGLDLVRKMLAQAADYLTEDGLIVIEVGNSEWAMKQNFNTVDFHWLQFQKGG 312
Cdd:TIGR00536 214 VGGDDGLNILRQIIELAPDYLKPNGFLVCEIGNWQQKSLKELLRIKFTWYDVENGR 269
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 65-288 4.52e-69

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 216.95  E-value: 4.52e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  65 DAEIL----------------DAKLLPSEKQEFLSLLERRINeRTPTSYLLNLAYFYGKPFYVDERVLIPRsP----IAE 124
Cdd:PRK09328  21 DAELLlahvlglsrtdlllnpEEELTPEELERFRALVARRAA-GEPLQYILGEAEFWGLDFKVSPGVLIPR-PeteeLVE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 125 LIENRFAPYcldengqmgeannnlpanpnpqMPRRILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAAINTEHHN 204
Cdd:PRK09328  99 WALEALLLK----------------------EPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 205 mQYQVALLESDLFSKIPAEnQYDLIVSNPPYVDAEDMADLPDEFR-HEPELALAAGQDGLDLVRKMLAQAADYLTEDGLI 283
Cdd:PRK09328 157 -GARVEFLQGDWFEPLPGG-RFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWL 234


                 ....*
gi 796853239 284 VIEVG 288
Cdd:PRK09328 235 LLEIG 239
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 65-288 4.96e-68

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 213.48  E-value: 4.96e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239   65 DAEIL----------------DAKLLPSEKQEFLSLLERRInERTPTSYLLNLAYFYGKPFYVDERVLIPRSPIAELIEn 128
Cdd:TIGR03534   1 DAELLlahvlgkdraqlllhpEDELTPEELAAFDALLARRA-AGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVE- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  129 rfapYCLDENGQMGeannnlpanpnpqmprRILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAAINTEHHNMQyQ 208
Cdd:TIGR03534  79 ----AALERLKKGP----------------RVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLE-N 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  209 VALLESDLFSKIPAEnQYDLIVSNPPYVDAEDMADLPDEFR-HEPELALAAGQDGLDLVRKMLAQAADYLTEDGLIVIEV 287
Cdd:TIGR03534 138 VEFLQGDWFEPLPSG-KFDLIVSNPPYIPEADIHLLDPEVRdFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEI 216


                  .
gi 796853239  288 G 288
Cdd:TIGR03534 217 G 217
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 69-291 3.85e-35

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 133.84  E-value: 3.85e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  69 LDAKLLPSEKQEFLSLLERRInERTPTSYLLNLAYFYGKPFYVDERVLIPRSPIAELIENRFapYCLDENGQMGEANNNL 148
Cdd:PRK01544  47 LDEQLNEAEIEAFEKLLERRL-KHEPIAYITGVKEFYSREFIVNKHVLIPRSDTEVLVDVVF--QCHSRESGNPEKKQLN 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 149 PANPNPQMPRR-------ILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAAINTEHHNMQYQVALLESDLFSKIp 221
Cdd:PRK01544 124 PCFRGNDISSNcndkflnILELGTGSGCIAISLLCELPNANVIATDISLDAIEVAKSNAIKYEVTDRIQIIHSNWFENI- 202

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 796853239 222 AENQYDLIVSNPPYVDAEDMADLPDE-FRHEPELALAAGQDGLDLVRKMLAQAADYLTEDGLIVIEVGNSE 291
Cdd:PRK01544 203 EKQKFDFIVSNPPYISHSEKSEMAIEtINYEPSIALFAEEDGLQAYFIIAENAKQFLKPNGKIILEIGFKQ 273
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 74-293 1.85e-28

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 114.02  E-value: 1.85e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  74 LPSE-KQEFLSLLERRINERtPTSYLLNLAYFYGKPFYVDERVLIPRSPIAELIENRFAPycLDENGqmgeannnlpanp 152
Cdd:PRK14966 190 MPDEvRQRADRLAQRRLNGE-PVAYILGVREFYGRRFAVNPNVLIPRPETEHLVEAVLAR--LPENG------------- 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 153 npqmprRILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAAINTEhhNMQYQVALLESDLF-SKIPAENQYDLIVS 231
Cdd:PRK14966 254 ------RVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARKNAA--DLGARVEFAHGSWFdTDMPSEGKWDIIVS 325

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 796853239 232 NPPYVDAEDMADLPDEFRHEPELALAAGQDGLDLVRKMLAQAADYLTEDGLIVIEVGNSEWA 293
Cdd:PRK14966 326 NPPYIENGDKHLLQGDLRFEPQIALTDFSDGLSCIRTLAQGAPDRLAEGGFLLLEHGFDQGA 387
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 157-290 3.24e-22

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 92.18  E-value: 3.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 157 PRRILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAAINTEHHNMQyQVALLESDLFSKIPAEnQYDLIVSNPPyv 236
Cdd:COG2813   50 GGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLE-NVEVLWSDGLSGVPDG-SFDLILSNPP-- 125

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 796853239 237 daedmadlpdeFRhepelalAAGQDGLDLVRKMLAQAADYLTEDGLIVIeVGNS 290
Cdd:COG2813  126 -----------FH-------AGRAVDKEVAHALIADAARHLRPGGELWL-VANR 160
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 157-285 3.41e-20

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 87.89  E-value: 3.41e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 157 PRRILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAAINTEHHNMQYQVALLESDL--FSKIPAENQYDLIVSNPP 234
Cdd:COG4123   38 GGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDRITVIHGDLkeFAAELPPGSFDLVVSNPP 117

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 796853239 235 YVDAEDMADLPDEF----RHEPELALAagqdglDLVRKmlaqAADYLTEDGLIVI 285
Cdd:COG4123  118 YFKAGSGRKSPDEAraiaRHEDALTLE------DLIRA----AARLLKPGGRFAL 162
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 158-301 3.91e-19

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 83.02  E-value: 3.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  158 RRILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAAINTEHHNMQyQVALLESDLFSKIPaENQYDLIVSNPPyvd 237
Cdd:pfam05175  33 GKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLE-NGEVVASDVYSGVE-DGKFDLIISNPP--- 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 796853239  238 aedmadlpdeFRhepelalAAGQDGLDLVRKMLAQAADYLTEDGLIVIeVGNS----EWAMKQNFNTV 301
Cdd:pfam05175 108 ----------FH-------AGLATTYNVAQRFIADAKRHLRPGGELWI-VANRflgyPPLLEELFGNV 157
PRK14968 PRK14968
putative methyltransferase; Provisional
 159-285 2.58e-17

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 78.79  E-value: 2.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 159 RILDMCTGSGCIAIALAYAfpDAEVDATDISKDALEVAAINTEHHNM-QYQVALLESDLFSKIpAENQYDLIVSNPPYvd 237
Cdd:PRK14968  26 RVLEVGTGSGIVAIVAAKN--GKKVVGVDINPYAVECAKCNAKLNNIrNNGVEVIRSDLFEPF-RGDKFDVILFNPPY-- 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 796853239 238 aedmadLPDEFRHEP----ELALAAGQDGLDLVRKMLAQAADYLTEDGLIVI 285
Cdd:PRK14968 101 ------LPTEEEEEWddwlNYALSGGKDGREVIDRFLDEVGRYLKPGGRILL 146
PRK14967 PRK14967
putative methyltransferase; Provisional
 158-285 2.32e-14

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 71.24  E-value: 2.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 158 RRILDMCTGSGCIAIALAYAfPDAEVDATDISKDALEVAAINTEHHNMqyQVALLESDLFSKIPaENQYDLIVSNPPYVD 237
Cdd:PRK14967  38 RRVLDLCTGSGALAVAAAAA-GAGSVTAVDISRRAVRSARLNALLAGV--DVDVRRGDWARAVE-FRPFDVVVSNPPYVP 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 796853239 238 AEDMAdLPDefrHEPELALAAGQDGLDLVRKMLAQAADYLTEDGLIVI 285
Cdd:PRK14967 114 APPDA-PPS---RGPARAWDAGPDGRAVLDRLCDAAPALLAPGGSLLL 157
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 159-287 5.25e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.98  E-value: 5.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 159 RILDMCTGSGCIAIALAyAFPDAEVDATDISKDALEVAAINTEHHNMQYqVALLESDLFS-KIPAENQYDLIVSNPPYvd 237
Cdd:cd02440    1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKAAAALLADN-VEVLKGDAEElPPEADESFDVIISDPPL-- 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 796853239 238 aedmadlpdefrhepelalaagQDGLDLVRKMLAQAADYLTEDGLIVIEV 287
Cdd:cd02440   77 ----------------------HHLVEDLARFLEEARRLLKPGGVLVLTL 104
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
157-232 2.15e-09

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 54.06  E-value: 2.15e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 796853239 157 PRRILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAAINTEHhnmqyqVALLESDLFSkIPAENQYDLIVSN 232
Cdd:COG4106    2 PRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPN------VRFVVADLRD-LDPPEPFDLVVSN 70
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 157-289 2.51e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 54.64  E-value: 2.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 157 PRRILDMCTGSGCIAIALAYAFpdAEVDATDISKDALEVAAINTEHHNMQYQVAllesDLFSKIPAENQYDLIVSNppYV 236
Cdd:COG2227   25 GGRVLDVGCGTGRLALALARRG--ADVTGVDISPEALEIARERAAELNVDFVQG----DLEDLPLEDGSFDLVICS--EV 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 796853239 237 daedMADLPDefrhepelalaagqdgldlVRKMLAQAADYLTEDGLIVIEVGN 289
Cdd:COG2227   97 ----LEHLPD-------------------PAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 160-232 2.37e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.03  E-value: 2.37e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 796853239  160 ILDMCTGSGCIAIALAYAFpDAEVDATDISKDALEVAAINTEHHNMqyQVALLESDLFSKIPAENQYDLIVSN 232
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLPFPDGSFDLVVSS 70
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
158-232 8.24e-08

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 52.87  E-value: 8.24e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 796853239 158 RRILDMCTGSGCIAIAlAYAFPDAEVDATDISKDALEVAAINTEHHNMQYQVALLESDLFskipAENQYDLIVSN 232
Cdd:COG2264  150 KTVLDVGCGSGILAIA-AAKLGAKRVLAVDIDPVAVEAARENAELNGVEDRIEVVLGDLL----EDGPYDLVVAN 219
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
159-290 8.52e-08

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 53.02  E-value: 8.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 159 RILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAAINTEHHNMQYQValLESDLFSKIpaENQYDLIVSNPPYVDA 238
Cdd:PRK09489 199 KVLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRATLAANGLEGEV--FASNVFSDI--KGRFDMIISNPPFHDG 274

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 796853239 239 EDMAdlpdefrhepelalaagqdgLDLVRKMLAQAADYLTEDGLIVIeVGNS 290
Cdd:PRK09489 275 IQTS--------------------LDAAQTLIRGAVRHLNSGGELRI-VANA 305
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
158-234 2.08e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 50.67  E-value: 2.08e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 796853239 158 RRILDMCTGSGCIAIALAYAFPdAEVDATDISKDALEVAAINTEhhNMQYQVALLESDlFSKIPAENQYDLIVSNPP 234
Cdd:COG2263   47 KTVLDLGCGTGMLAIGAALLGA-KKVVGVDIDPEALEIARENAE--RLGVRVDFIRAD-VTRIPLGGSVDTVVMNPP 119
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 158-305 5.90e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 46.10  E-value: 5.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 158 RRILDMCTGSGCIAIALAYAfpDAEVDATDISKDALEVAAINTEHHNMQYqVALLESDlFSKIP-AENQYDLIVSNPPYV 236
Cdd:COG1041   28 DTVLDPFCGTGTILIEAGLL--GRRVIGSDIDPKMVEGARENLEHYGYED-ADVIRGD-ARDLPlADESVDAIVTDPPYG 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 796853239 237 DAedmadlpdefrhepelALAAGQDGLDLVRKMLAQAADYLTEDGLIVIeVGNSEW---AMKQNFNTVDFHW 305
Cdd:COG1041  104 RS----------------SKISGEELLELYEKALEEAARVLKPGGRVVI-VTPRDIdelLEEAGFKVLERHE 158
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 157-232 7.46e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 44.98  E-value: 7.46e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 796853239 157 PRRILDMCTGSGCIAIALAYAfpDAEVDATDISKDALEVAAINTEHHNmqYQVALLESDlFSKIP-AENQYDLIVSN 232
Cdd:COG2226   23 GARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAG--LNVEFVVGD-AEDLPfPDGSFDLVISS 94
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
157-232 1.04e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 46.30  E-value: 1.04e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 796853239 157 PRRILDMCTGSGCIAIALAY--AfpdAEVDATDISKDALEVAAINTEHHNMQYQVALLESDLfskipaenQYDLIVSN 232
Cdd:PRK00517 120 GKTVLDVGCGSGILAIAAAKlgA---KKVLAVDIDPQAVEAARENAELNGVELNVYLPQGDL--------KADVIVAN 186
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 159-285 1.49e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 44.54  E-value: 1.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 159 RILDMCTGSGCIAIALAYAFpDAEVDATDISKDALEVAAINTEHHNMQYQVALLESDlFSKIPAENQYDLIVSNppyvda 238
Cdd:COG2230   54 RVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLAD-YRDLPADGQFDAIVSI------ 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 796853239 239 eDMadlpdeFRHEPELALAAgqdgldlvrkMLAQAADYLTEDGLIVI 285
Cdd:COG2230  126 -GM------FEHVGPENYPA----------YFAKVARLLKPGGRLLL 155
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
157-291 3.18e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 43.83  E-value: 3.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 157 PRRILDMCTGSGCIAIALAYAFpdAEVDATDISKDALEVAAintehhNMQYQVALLESDLFSKIPAENQYDLIVSNppyv 236
Cdd:COG4976   47 FGRVLDLGCGTGLLGEALRPRG--YRLTGVDLSEEMLAKAR------EKGVYDRLLVADLADLAEPDGRFDLIVAA---- 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 796853239 237 daedmadlpDEFRHEPELalaagqdgldlvRKMLAQAADYLTEDGLIVIEVGNSE 291
Cdd:COG4976  115 ---------DVLTYLGDL------------AAVFAGVARALKPGGLFIFSVEDAD 148
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 161-232 3.64e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 41.97  E-value: 3.64e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 796853239  161 LDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAA--INTEHHNMQYQVALLESDLFSkiPAENQYDLIVSN 232
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARerLAALGLLNAVRVELFQLDLGE--LDPGSFDVVVAS 72
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 159-232 4.74e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 42.79  E-value: 4.74e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 796853239  159 RILDMCTGSGCIAIALAY-AFPDAEVDATDISKDALEVAAINTEHHNMQyQVALLESDlFSKIP---AENQYDLIVSN 232
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEeLGPNAEVVGIDISEEAIEKARENAQKLGFD-NVEFEQGD-IEELPellEDDKFDVVISN 81
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 159-286 5.57e-05

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 43.15  E-value: 5.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 159 RILDMCTGSGCIAI-AL---AyafpdAEVDATDISKDALEVAAINTEHHNMQYQVALLESDLFS--KIPAENQYDLIVSN 232
Cdd:COG0742   44 RVLDLFAGSGALGLeALsrgA-----ASVVFVEKDRKAAAVIRKNLEKLGLEDRARVIRGDALRflKRLAGEPFDLVFLD 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 796853239 233 PPYvdaedmadlpdefrhepelalaagqdGLDLVRKMLAQAADY--LTEDGLIVIE 286
Cdd:COG0742  119 PPY--------------------------AKGLLEKALELLAENglLAPGGLIVVE 148
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 157-234 3.15e-04

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 42.09  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 157 PRRILDMCTGSGCIAIALAYAFpdAEVDATDISKDALEVAAINTEHHNMQyQVALLESDLFSKIPAE---NQYDLIVSNP 233
Cdd:COG2265  234 GERVLDLYCGVGTFALPLARRA--KKVIGVEIVPEAVEDARENARLNGLK-NVEFVAGDLEEVLPELlwgGRPDVVVLDP 310


                 .
gi 796853239 234 P 234
Cdd:COG2265  311 P 311
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 159-215 3.16e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 41.68  E-value: 3.16e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 796853239 159 RILDMCTGSGCIAIALA-YAFPDAEVDATDISKDALEVAAINTEHHNMQYQVALLESD 215
Cdd:PRK00216  54 KVLDLACGTGDLAIALAkAVGKTGEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGD 111
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 158-234 3.80e-04

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 42.09  E-value: 3.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239 158 RRILDMC--TGSGCIAIALAYAfpdAEVDATDISKDALEVAAINTEHHNMQYQVALLESDLF----SKIPAENQYDLIVS 231
Cdd:COG1092  218 KRVLNLFsyTGGFSVHAAAGGA---KSVTSVDLSATALEWAKENAALNGLDDRHEFVQADAFdwlrELAREGERFDLIIL 294


                 ...
gi 796853239 232 NPP 234
Cdd:COG1092  295 DPP 297
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 157-232 1.03e-03

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 39.96  E-value: 1.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 796853239  157 PRRILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAaintEHHNMQyQVALLESDLFSKIPAENQYDLIVSN 232
Cdd:TIGR02072  35 PASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQA----KTKLSE-NVQFICGDAEKLPLEDSSFDLIVSN 105
N6_Mtase pfam02384
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
 158-257 2.50e-03

N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.


Pssm-ID: 426749 [Multi-domain]  Cd Length: 310  Bit Score: 39.23  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  158 RRILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEV-------AAINTEHHNMQY---QVAL---LESDLFSKipaEN 224
Cdd:pfam02384  47 ESIYDPACGSGGFLIQAEKFVKEHDGDTNDLSIYGQEKnpttyrlARMNMILHGIEYddfHIRHgdtLTSPKFED---DK 123

                          90       100       110
                  ....*....|....*....|....*....|....
gi 796853239  225 QYDLIVSNPPYVDAEDM-ADLPDEFRHEPELALA 257
Cdd:pfam02384 124 KFDVVVANPPFSDKWDAnDTLENDPRFRPAYGVA 157
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
158-229 3.26e-03

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 38.06  E-value: 3.26e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 796853239 158 RRILDMCTGSGCIAIALAYAFPDAEVDATDISKDALEVAAINTEHHNMQyQVALLESdlFSKIPAENQYDLI 229
Cdd:PRK08287  33 KHLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGCG-NIDIIPG--EAPIELPGKADAI 101
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 157-232 4.93e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 37.59  E-value: 4.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 796853239 157 PRRILDMCTGSGCIAIALAYAFpDAEVDATDISKDALEvAAINTEHHNMQYQVALLESDLF-SKIPAENQYDLIVSN 232
Cdd:COG0500   27 GGRVLDLGCGTGRNLLALAARF-GGRVIGIDLSPEAIA-LARARAAKAGLGNVEFLVADLAeLDPLPAESFDLVVAF 101
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 157-230 5.12e-03

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 37.31  E-value: 5.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 796853239  157 PRRILDMCTGSGCIAIALAYAFPDAEVDATDIsKDALEVAAINTEHHNMQYQVAL--------LESDLFSKIPaenqYDL 228
Cdd:pfam10294  47 GLNVLELGSGTGLVGIAVALLLPGASVTITDL-EEALELLKKNIELNALSSKVVVkvldwgenLPPDLFDGHP----VDL 121


                  ..
gi 796853239  229 IV 230
Cdd:pfam10294 122 IL 123
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 173-235 6.21e-03

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 38.16  E-value: 6.21e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 796853239 173 ALAYAFPDAEVD--ATDISKDALEVAAINTEHHNMQYQVALLESDlFSKIPAENQYDLIVSNPPY 235
Cdd:COG0116  241 AEARIKRDPPLPifGSDIDPRAIEAARENAERAGVADLIEFEQAD-FRDLEPPAEPGLIITNPPY 304
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 158-232 6.37e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 38.02  E-value: 6.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 796853239  158 RRILDMCTGSGCIAIALAYaFPDAEVDATDISKDALEVAAINTEHHNM--QYQVALLESdlfskIPAEnQYDLIVSN 232
Cdd:pfam06325 163 ESVLDVGCGSGILAIAALK-LGAKKVVGVDIDPVAVRAAKENAELNGVeaRLEVYLPGD-----LPKE-KADVVVAN 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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