|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
25-426 |
3.43e-59 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 198.55 E-value: 3.43e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 25 IMTTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCAL 104
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 105 AKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAINVLPG 184
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 185 tlalllavkalprdavrkqapfdtlgaiLSALLLGSTivaanslhdatyhtgslcwtvlaalsgmafiwqirrtdnpllp 264
Cdd:cd17321 161 ----------------------------LVALLLART------------------------------------------- 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 265 paifknerFTLAALTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVISTLGL 344
Cdd:cd17321 170 --------FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 345 MIFVVGLILLATLPASPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVGVLLA 424
Cdd:cd17321 242 LLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT 321
|
..
gi 782731598 425 TN 426
Cdd:cd17321 322 AG 323
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
24-423 |
6.81e-53 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 184.89 E-value: 6.81e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 24 AIMTTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCA 103
Cdd:TIGR00711 6 VLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 104 LAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAINVLP 183
Cdd:TIGR00711 86 VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 184 GTLALLLAVKALPRDAVRKQAPFDTLGAILSALLLGS--TIVAANSLHDATYHTGSLCWTVLAALSGMAFIWQIRRTDNP 261
Cdd:TIGR00711 166 GIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSllYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWELTDDNP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 262 LLPPAIFKNERFTLAALTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVIST 341
Cdd:TIGR00711 246 LVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVT 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 342 LGLMIFVVGLILLA-TLPASPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVG 420
Cdd:TIGR00711 326 IGLILYAVGFYWRAfTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALIT 405
|
...
gi 782731598 421 VLL 423
Cdd:TIGR00711 406 TIL 408
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
25-428 |
2.96e-44 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 159.28 E-value: 2.96e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 25 IMTTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCAL 104
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 105 AKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAINVLPG 184
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 185 tlalllavkalprdavrkqapfdtlgaILSALLLgstivaanslhdatyhtgslcwtvlaalsgmafiwqirrtdnPLLP 264
Cdd:cd17503 161 ---------------------------ILALLLA------------------------------------------PLLD 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 265 PAIFKNERFTLAALTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVISTLGL 344
Cdd:cd17503 172 LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGL 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 345 MIFVVGLILLATLPASPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVGVLLA 424
Cdd:cd17503 252 LLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331
|
....
gi 782731598 425 TNER 428
Cdd:cd17503 332 NRTQ 335
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-412 |
2.62e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 133.95 E-value: 2.62e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 14 PGPTRARVMAAIMTTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLT 93
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 94 TFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSW 173
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 174 QWLFAINVLPGTLALLLAVKALPRDAVRKQAPFDTlgailsalllgstivaanslhdatyhtgslcwtvlaalsgmafiw 253
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLRG--------------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 254 qirrtdnplLPPAIFKNERFTLAALTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADT 333
Cdd:COG2814 199 ---------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 782731598 334 ISAPVISTLGLMIFVVGLILLATlpaSPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQ 412
Cdd:COG2814 270 FGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
11-298 |
6.66e-29 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 115.29 E-value: 6.66e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 11 DGLPGPTRARVMAAIMTTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLA 90
Cdd:COG0477 5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 91 GLTTFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHT 170
Cdd:COG0477 85 GLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 171 LSWQWLFAINVLPGTLALLLAVKALPRDAVRKQAPFDTLGAILSALLLGSTIVAANSLHDATYHTGSLCWTVLAALSGMA 250
Cdd:COG0477 165 LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLA 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 782731598 251 FIWQIRRTDNPLLPPAIFKNERFTLAALTSMIAFVSQGITFIALPFLF 298
Cdd:COG0477 245 LLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
25-417 |
1.22e-28 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 115.35 E-value: 1.22e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 25 IMTTTLMGVFDGTMINIALPSMAQKMQVPASYAvWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCAL 104
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVS-WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 105 AKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAINvLPg 184
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYIN-LP- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 185 tlalllavkalprdavrkqapfdtLGAILSALLLGSTIVAANSLhdatyhtgslcwtvlaaLSGMAFIwqirrtdnpllp 264
Cdd:cd17502 158 ------------------------IGGLALALLRTILLSSIFGF-----------------LFGGALF------------ 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 265 paifknerftlaaltsmiafvsqgITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRW-ADTISAPVISTLG 343
Cdd:cd17502 185 ------------------------GLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALiSKTGRYKPLIVIG 240
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 782731598 344 LMIFVVGLILLATLPASPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAA 417
Cdd:cd17502 241 TILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVA 314
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
37-426 |
3.37e-26 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 109.20 E-value: 3.37e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 37 TMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRV 116
Cdd:cd17504 13 TMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 117 LQGIGGAaTLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFainvlpgtlalllavkalp 196
Cdd:cd17504 93 LQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIF------------------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 197 rdavrkqapfdtlgailsalllgstivaanslhdatyHTGSLCWTVLAALSgmafiwqirrtdnPLLPPAIFKNERFTLA 276
Cdd:cd17504 153 -------------------------------------WTAAPVAVLLAALV-------------PLIDLRLLRRRNVLLA 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 277 ALTSMIAFVSQGITFIALPFLFQSE----YGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVISTLGLMIFVVGLI 352
Cdd:cd17504 183 NITALLAGFGMFMVFQLLPQLLQLPtptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLL 262
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 782731598 353 LLATLPASpsMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVGVLLATN 426
Cdd:cd17504 263 LLALLHSS--LWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTY 334
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
37-422 |
4.29e-26 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 109.20 E-value: 4.29e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 37 TMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRV 116
Cdd:cd17320 16 DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 117 LQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAInvlpgtlalllavkalp 196
Cdd:cd17320 96 LQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF----------------- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 197 rdavrkQAPFDTLGAILSALLLGSTIVAANSlhdatyhtGSLCWTVLAALSgmafiwqirrtdnpllppAIFKNERFTLA 276
Cdd:cd17320 159 ------LALLGLLLLLLVLLFLPETLPEEKR--------KPLLSSLLRAYK------------------RVLKNRRFLGY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 277 ALTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVISTLGLMIFVVGLILLAT 356
Cdd:cd17320 207 ALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLL 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 782731598 357 LPASPSMWDICLRSLVCGMGFGC-FQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVGVL 422
Cdd:cd17320 287 AALLGGLSLWPLVAPLFLIFFGFgLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLL 353
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
31-425 |
4.26e-22 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 98.65 E-value: 4.26e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 31 MGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEV 110
Cdd:PRK10504 21 MQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 111 LIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAINVLPGTLALLL 190
Cdd:PRK10504 101 LLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 191 AVKALPRDAVRKQApFDTLGAILSALLLGSTIVAANSLHDATYHTGSLCWTVLAALSGMA-FIWQIRRTDNPLLPPAIFK 269
Cdd:PRK10504 181 TLMLMPNYTMQTRR-FDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLlYLLHARNNNRALFSLKLFR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 270 NERFTLAALTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLG-------IVLIAPHAGRWadtiSAPVISTL 342
Cdd:PRK10504 260 TRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGsmgmkriVVQVVNRFGYR----RVLVATTL 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 343 GLMIFVVGLILLATLPAspsMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVGVL 422
Cdd:PRK10504 336 GLALVSLLFMLVALLGW---YYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLL 412
|
...
gi 782731598 423 LAT 425
Cdd:PRK10504 413 LGL 415
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
30-355 |
2.58e-21 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 95.14 E-value: 2.58e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 30 LMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPE 109
Cdd:TIGR00710 15 ILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 110 VLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAINVLPGtlall 189
Cdd:TIGR00710 95 TLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAG----- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 190 lavkalprdavrkqapfdTLGAILSALLLGSTIVAANSLHDATYhtgslcWTVLAALsgmafiwqirrtdnpllppaiFK 269
Cdd:TIGR00710 170 ------------------ILLSALIFFILPETLPYEARIQISTY------FETFLLL---------------------LK 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 270 NERFTLAALTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVISTLGLMIFVV 349
Cdd:TIGR00710 205 SKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAV 284
|
....*.
gi 782731598 350 GLILLA 355
Cdd:TIGR00710 285 SAVLLE 290
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-425 |
6.67e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 93.79 E-value: 6.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 27 TTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAK 106
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 107 TPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAInvlpgtl 186
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 187 alllavkalprdavrkQAPFDTLGAILSALLLGSTIVAANSLHDATYHTGSLCWTVLaalsgmafiwqirrtdnpllppa 266
Cdd:cd17325 156 ----------------CAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLL----------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 267 ifKNERFTLAALTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVISTLGLMI 346
Cdd:cd17325 197 --RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 782731598 347 FVVGLILlatLPASPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVGVLLAT 425
Cdd:cd17325 275 SAVALLL---LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA 350
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
25-416 |
1.30e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 92.48 E-value: 1.30e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 25 IMTTTLMGVFDGTMINIALPS-MAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCA 103
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 104 LAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAINVLP 183
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 184 GTLALLLAVKALPRDAVRKQAPFDTLGAILSALLLgstivaanslhdatyhtgslcwtvlaalsgmafiwqirrtdnpll 263
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWK--------------------------------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 264 ppaIFKNERFTLAALTSMIAFVSQGITFIALPfLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVISTLG 343
Cdd:pfam07690 196 ---ALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA 271
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 782731598 344 LMIFVVGLILLATLPASPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGA 416
Cdd:pfam07690 272 LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
29-424 |
3.92e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 91.48 E-value: 3.92e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 29 TLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTP 108
Cdd:cd17474 8 TLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 109 EVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGtILHTLSWQWLFAInvlpgtlal 188
Cdd:cd17474 88 ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGG-LLAAISWRYPFFL--------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 189 llavkalprdavrkqapfdTLGAILSALLLGSTIVAANSLHDAtyhtgslcWTVLAALSGMAFiwqirrtdnpllppaIF 268
Cdd:cd17474 158 -------------------LAALIPVAFLAILFLLPEPKEKAK--------SSSATKLRDLKK---------------AL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 269 KNERFTLAALTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRW-ADTISAPVISTLGLMIF 347
Cdd:cd17474 196 RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLlKKRFGARRILVIGLLLY 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 782731598 348 VVGLILlatLPASPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVGVLLA 424
Cdd:cd17474 276 ALSLLL---LGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLE 349
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-184 |
8.76e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 84.54 E-value: 8.76e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 11 DGLPGPTRARVMAAIMTTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLA 90
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 91 GLTTFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHT 170
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170
....*....|....
gi 782731598 171 LSWQWLFAINVLPG 184
Cdd:COG2271 161 FGWRAAFLILGLPG 174
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
25-181 |
1.83e-16 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 80.70 E-value: 1.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 25 IMTTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCAL 104
Cdd:cd17323 4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCAL 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 782731598 105 AKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAINV 181
Cdd:cd17323 84 APNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
35-364 |
6.22e-16 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 79.77 E-value: 6.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 35 DGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGM 114
Cdd:PRK14995 21 DATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIAT 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 115 RVLQGIGGAATLSIAPAILRSVF-PGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAINVLPGTLALLLAVK 193
Cdd:PRK14995 101 RALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTAR 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 194 ALPRDAVRKQAPFDTLGAIlsaLLLGSTIVAANSLHDATYHTGSLCWTVLAALSGMA----FIWQIRRTDNPLLPPAIFK 269
Cdd:PRK14995 181 YVPRQAGRRDQPLNLGHAL---MLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALllglFIRTQLAASRPMIDMRLFT 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 270 NERFT---LAALTSMIAFV------SQGITFIalpflfqseYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVIS 340
Cdd:PRK14995 258 HRIILsgvVMAMTAMITLVgfellmAQELQFV---------HGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVA 328
|
330 340
....*....|....*....|....
gi 782731598 341 TLGLMIFVVGLILLATLPASPSMW 364
Cdd:PRK14995 329 TGGMALSALSFYGLAMTDFSTQQW 352
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
74-180 |
1.82e-14 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 70.37 E-value: 1.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 74 IFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLI 153
Cdd:TIGR00880 17 LSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGI 96
|
90 100
....*....|....*....|....*..
gi 782731598 154 ASSSAIGPVLGGTILHTLSWQWLFAIN 180
Cdd:TIGR00880 97 ALGPLLGPPLGGVLAQFLGWRAPFLFL 123
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
43-424 |
5.62e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 69.89 E-value: 5.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 43 LPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGIGG 122
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 123 AATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAINVLPGTLALLLAVKALPRDAVRK 202
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 203 QAPFDTLGAILsalllgstivaanslhdatyhtgslcwtvlaalsgmafiwqirrtdnpllppAIFKNERFTLAALTSMI 282
Cdd:cd17324 182 PGSLGLLSSLL----------------------------------------------------LLLRNPRLRLAYLITFL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 283 AFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVISTLGLMIFVVGLILLATlpaSPS 362
Cdd:cd17324 210 LFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLL---GPS 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 782731598 363 MWDICLRSLVCGMGFGCFQSPNNReMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVGVLLA 424
Cdd:cd17324 287 PLLLLVGLVLWGLGFFAAHSALQT-RVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLD 347
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
41-180 |
9.34e-13 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 69.21 E-value: 9.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 41 IALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGI 120
Cdd:cd17476 19 VILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGL 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 782731598 121 GGAATLSIAPAILRSVF-PGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAIN 180
Cdd:cd17476 99 GPAFLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL 159
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
42-177 |
3.70e-12 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 67.63 E-value: 3.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 42 ALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGIG 121
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 782731598 122 GAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLF 177
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIF 148
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-425 |
8.80e-12 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 66.44 E-value: 8.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 18 RARVMAAIMTTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTL 97
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 98 TSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLF 177
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 178 ainvlpgtlalllavkalprdavrkqapfdtlgAILSALLLGSTIVAANSLHDATYHTGSlcwTVLAALSGMAfiwqirr 257
Cdd:COG2223 163 ---------------------------------LILGILLLVVAVLAWLFLRDPPAGAAA---AAKASLRDQL------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 258 tdnpllppAIFKNERFTLAALTSMIAFVSqGITFIA-LPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISA 336
Cdd:COG2223 200 --------EALRDPRFWLLSLLYFGTFGS-FIGFSSwLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 337 PVISTLGLMIFVVGLILLATLPASPSMWDICLrsLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGA 416
Cdd:COG2223 271 RRVLLIVFALMALGLLLLALALGSLWLFLVLF--LLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGP 348
|
....*....
gi 782731598 417 AAVGVLLAT 425
Cdd:COG2223 349 LLFGALLDA 357
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-425 |
1.49e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 65.91 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 34 FDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIG 113
Cdd:cd06174 10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 114 MRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTIL--HTLSWQWLFAINvlpgtlallla 191
Cdd:cd06174 90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIA----------- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 192 vkalprdavrkqapfdtlgAILSALLLGSTIVAANSLHDATYHTGSLCWTvlaalsgmafiwqirrTDNPLLPPAIFKNE 271
Cdd:cd06174 159 -------------------AALALLAAILLLLVVPDPPESARAKNEEASS----------------KSVLKLLKRVLKNP 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 272 RFTLAALTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISApvISTLGLMIFVVGL 351
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG--RKPLLLIGLLLMA 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 782731598 352 ILLATLPASPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVGVLLAT 425
Cdd:cd06174 282 LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
38-424 |
2.66e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 64.92 E-value: 2.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 38 MINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVL 117
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 118 QGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAInvlpgtlalllavkalpr 197
Cdd:cd17489 94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV------------------ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 198 davrkqAPFDTLGAILSALLLGSTIVAANSLHDATyhtgslcwtvlaalsgmafiwqirrtdnpLLPPAIFKNERFTLAA 277
Cdd:cd17489 156 ------AAVLALLALLLVFLVKDPPPVAAEEAEAG-----------------------------TRAFRRLVEKKVLPPA 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 278 LTSMIAFVSQG--ITFIAlpfLFQSEYGYSpvISALLFTPWPLGIVLIAPHAGRWADTISAPVISTLGLMIFVVGLILLA 355
Cdd:cd17489 201 LILFLASIAYGaiSTFLP---LYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLS 275
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 782731598 356 tlpASPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVGVLLA 424
Cdd:cd17489 276 ---FAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE 341
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
32-425 |
9.17e-11 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 63.80 E-value: 9.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 32 GVFDGTMINIALPSMAQKMQvPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVL 111
Cdd:cd06179 10 QLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNML 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 112 IGMRVLQGIgGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHT--LSWQWLFAIN-VLPGTLAL 188
Cdd:cd06179 89 IGGQALIGI-GAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEAnaAGWRWIFYINaIFNALALI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 189 LLAVKALPRDAVRKQAPFDT-----------------LGAILSALLLGSTIVAANSLHdatyhtgSLCWTVLAALSGMAF 251
Cdd:cd06179 168 LLFFFYHPPPRPQLHGSSTRqklkrldwvglflliagLVLFLLGLSWGGNPYPWSSAH-------VIAPLVIGGVLLIAF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 252 -IWQIRRTDNPLLPPAIFKNERFTLAALTsmIAFVSqGITFIALPFLFQSE----YGYSPVISALLFTPWPLGIVLIAPH 326
Cdd:cd06179 241 gLYEWKGTKDGLLPPRLLFRGRNFALILI--VAFVE-GMIFYSLNIFWPQQisllFTTDPLKAGLYQLPFGLGTLFGAIL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 327 AGRWADTIS-APVISTLGLMIFVVGLILLATLPASPSMWDICLrSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLS 405
Cdd:cd06179 318 AGLLLTKIKhIKWQLVAGFVLFTAFLALLALITPDNKALAIAF-SVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLG 396
|
410 420
....*....|....*....|
gi 782731598 406 IMRTFGQCLGAAAVGVLLAT 425
Cdd:cd06179 397 SARALGGAVGTAIFTSILSN 416
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
24-426 |
3.17e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 61.44 E-value: 3.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 24 AIMTTTLMGVFDGTMINIALPSMAQKMQVPASYAV-WFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGC 102
Cdd:cd17473 3 TLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVpLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 103 ALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGtILHTLSWQWLFAINVL 182
Cdd:cd17473 83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGG-ALAEIGWRAPFLVYLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 183 pgtlalllavkalprdavrkqapfdtlgAILSALLLgstivaanslhdatyhtgslcwtvlaalsgMAFIW-----QIRR 257
Cdd:cd17473 162 ----------------------------ALPVLILV------------------------------LLFLPeparkSKSA 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 258 TDNPLLPPAIFKNERFTLAALTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAP 337
Cdd:cd17473 184 ASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKR 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 338 VISTLGLMIFVVGLILLATlpaSPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAA 417
Cdd:cd17473 264 RLLAIGFALMALGFLLLAL---ASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPL 340
|
....*....
gi 782731598 418 AVGVLLATN 426
Cdd:cd17473 341 VLGPLVNLT 349
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
38-179 |
8.80e-10 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 60.34 E-value: 8.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 38 MINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVL 117
Cdd:PRK15402 31 MIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFL 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 782731598 118 QGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAI 179
Cdd:PRK15402 111 QGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVL 172
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
64-177 |
3.18e-09 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 58.49 E-value: 3.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 64 YLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLG 143
Cdd:PRK10473 47 YLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRA 126
|
90 100 110
....*....|....*....|....*....|....
gi 782731598 144 RILGLHALLIASSSAIGPVLGGTILHTLSWQWLF 177
Cdd:PRK10473 127 KVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF 160
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
34-184 |
6.83e-09 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 57.58 E-value: 6.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 34 FDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIG 113
Cdd:cd17359 15 YDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFII 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 114 MRVLQGIG-GAATlSIAPAILRSVFPGRLLGRILGLHALLI--------ASSSAIGPVLGGTILHTLSWQWLFAINVLPG 184
Cdd:cd17359 95 ARIIGGLAvGGAS-ALVPMYIAEVAPAEIRGRLVSLNQLMIvfgqllayIVNYLIANAGGADWLGAEGWRWMLGLEAIPA 173
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
18-184 |
3.39e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 55.27 E-value: 3.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 18 RARVMAAIMTTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTL 97
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 98 TSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLF 177
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
....*..
gi 782731598 178 AINVLPG 184
Cdd:cd17319 161 IIEGLLG 167
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
37-178 |
8.27e-08 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 54.14 E-value: 8.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 37 TMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRV 116
Cdd:PRK11652 25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 782731598 117 LQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFA 178
Cdd:PRK11652 105 IQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYL 166
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
34-183 |
9.85e-08 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 53.81 E-value: 9.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 34 FDGTMINIALPSMAQKMQVPASYAVWFA---NGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEV 110
Cdd:cd17360 11 YDTGVISGALLYIKDDLGEVVLSTGWQElivSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEV 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 782731598 111 LIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHT-LSWQWLFAINVLP 183
Cdd:cd17360 91 LIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLpGGWRWMLGLAAVP 164
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
74-184 |
2.53e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 52.62 E-value: 2.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 74 IFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLI 153
Cdd:cd17328 53 IFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAI 132
|
90 100 110
....*....|....*....|....*....|..
gi 782731598 154 ASSSAIGPVLGGTI-LHTLSWQWLFAINVLPG 184
Cdd:cd17328 133 PLGSGLGYVVGGLVaQATGGWRWAFRVTGVLG 164
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
206-424 |
2.56e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.60 E-value: 2.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 206 FDTLGAILSALLLGSTIVAANSLHDATYHTGSLCWTVLAALSGMAFIWQIRRTDNPLLPP--------AIFKNERFTLAA 277
Cdd:COG2211 155 FAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKvslkeslkALLKNRPFLLLL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 278 LTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVISTLGLMIFVVGLILLATL 357
Cdd:COG2211 235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFL 314
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 782731598 358 PASPSMWdICLRSLVCGMGFGCFQsPNNREMLSNVSrDYASYASG---------VLSIMRTFGQCLGAAAVGVLLA 424
Cdd:COG2211 315 GPGNLWL-LLVLAALAGIGLGAIL-VLPWAMLADVV-DYDEWKTGrrreglyfgIFTFAIKLGQALAGALAGLLLA 387
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
34-184 |
1.03e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 50.68 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 34 FDGTMINIALPSMAQ--KMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVL 111
Cdd:cd17316 13 YDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILL 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 782731598 112 IGMRVLQGIGGAATLSIAPAILRSVFP----GRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAINVLPG 184
Cdd:cd17316 93 LVLRFLQGIGIGGEYPGASTYVAEFAPskrrGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPA 169
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
34-184 |
1.20e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.28 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 34 FDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIG 113
Cdd:cd17365 13 FDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 782731598 114 MRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAINVLPG 184
Cdd:cd17365 93 LRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPP 163
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
67-179 |
1.24e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 50.66 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 67 AAAMTLAIFAA-----------LAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRS 135
Cdd:PRK11043 42 AVSASLSLFLAgfalgqllwgpLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVID 121
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 782731598 136 VFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAI 179
Cdd:PRK11043 122 RYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFAT 165
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
16-179 |
2.74e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 49.28 E-value: 2.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 16 PTRARVMAAIMTTTLMGVFDG---TMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGL 92
Cdd:TIGR00895 10 PLSRYQWRAIILSFLIMLMDGydlAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 93 TTFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLS 172
Cdd:TIGR00895 90 LLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG 169
|
....*..
gi 782731598 173 WQWLFAI 179
Cdd:TIGR00895 170 WRSLFYV 176
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
23-214 |
3.92e-06 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 49.05 E-value: 3.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 23 AAIMTTTLMgvfDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAamtlaIFAALAARLGYRPVFLAGLTTFTLTSLGC 102
Cdd:PRK15403 27 AAYLTTDLI---QPGIINVVRDFNADVSLAPASVSLYLAGGMALQW-----LLGPLSDRIGRRPVLITGALIFTLACAAT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 103 ALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAINVL 182
Cdd:PRK15403 99 LFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAV 178
|
170 180 190
....*....|....*....|....*....|..
gi 782731598 183 PGTLALLLAVKALPRDAVRKQAPFdTLGAILS 214
Cdd:PRK15403 179 MGLIAFVGLLLAMPETVKRGAVPF-SAKSVLR 209
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
30-183 |
7.50e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 48.07 E-value: 7.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 30 LMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPE 109
Cdd:cd17371 9 ALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 110 VLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGlhalLIASSSAIGpVLGGTILHTL---------SWQWLFAIN 180
Cdd:cd17371 89 QLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALG----YVQSGWAVG-WLLATLLAALlfpllppeiAWRVLFLLG 163
|
...
gi 782731598 181 VLP 183
Cdd:cd17371 164 ALP 166
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
65-167 |
7.99e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.94 E-value: 7.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 65 LLAAAMTLAIFAA------LAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFP 138
Cdd:cd17477 35 LVASAYYLGILLGsplvprLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALAT 114
|
90 100
....*....|....*....|....*....
gi 782731598 139 GRLLGRILGLHALLIASSSAIGPVLGGTI 167
Cdd:cd17477 115 NENRGRVLGLYSTVLGLGFALGPLLLALV 143
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
21-179 |
2.19e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.49 E-value: 2.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 21 VMAAIMTTTLMGVFDGTMINIALPSMAQKMQVPASyAVWFANGYLLAAAMTLAIFAA-----LAARLGYRPVFLAGLTTF 95
Cdd:cd17391 202 LLISLFVTTFIIQLANQSIEPILTLYIRQLMGDAS-NLAFISGLVFSATGVSSLLSAprlgkLGDRIGHHRILLGALLAS 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 96 TLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQW 175
Cdd:cd17391 281 ALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRA 360
|
....
gi 782731598 176 LFAI 179
Cdd:cd17391 361 VFVV 364
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
51-179 |
4.36e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.61 E-value: 4.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 51 QVPASYAVwfangYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAP 130
Cdd:cd17370 235 LIPLLYAL-----FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIER 309
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 782731598 131 AILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAI 179
Cdd:cd17370 310 AAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
20-179 |
4.72e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.30 E-value: 4.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 20 RVMAAIMTTTLMGVFdGTMINIALPSMAQK-MQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLT 98
Cdd:cd06173 209 LLRLLLLALALFALL-GGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 99 SLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFA 178
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
.
gi 782731598 179 I 179
Cdd:cd06173 368 L 368
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
14-179 |
9.64e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.48 E-value: 9.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 14 PGPTRARVMAAIMTTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLT 93
Cdd:COG2807 12 RRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 94 TFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRlLGRILGLHALLIASSSAIGPVLGGTILHTLSW 173
Cdd:COG2807 92 LLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGW 170
|
....*.
gi 782731598 174 QWLFAI 179
Cdd:COG2807 171 RGALAV 176
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
46-179 |
1.00e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.48 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 46 MAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLG--YRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGIGGA 123
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 782731598 124 ATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFAI 179
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLL 342
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
24-425 |
1.26e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.14 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 24 AIMTTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCA 103
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 104 LA-----KTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTILHTLSWQWLFA 178
Cdd:cd06173 83 LLallgsLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 179 INVlpgtlalllavkalprdavrkqapfdtLGAILSALLLGSTIVAANSLHDAtyhtgSLCWTVLAALSGMAFIWQIRRT 258
Cdd:cd06173 163 INA---------------------------LSFLLSALLLLFIRRPPPAAPGE-----SSSLLLRDLREGLRYLRRSPLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 259 dnpllppaifknerfTLAALTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPV 338
Cdd:cd06173 211 ---------------RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 339 ISTLGLMIFVVGLILLAtlpASPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAA 418
Cdd:cd06173 276 LLLIGALLLGLALLVLG---LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352
|
....*..
gi 782731598 419 VGVLLAT 425
Cdd:cd06173 353 AGLLADA 359
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
264-425 |
1.92e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.42 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 264 PPAIFKNERFTLAALTSMIAFVSQGITFIALPFLfQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVISTLG 343
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLI-AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 344 LMIFVVGLILLATlpaSPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVGVLL 423
Cdd:COG2814 82 LLLFALGSLLCAL---APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
..
gi 782731598 424 AT 425
Cdd:COG2814 159 DL 160
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
59-184 |
2.04e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.41 E-value: 2.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 59 WFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAK---TPEVLIGMRVLQGIGGAATLSIAPAILRS 135
Cdd:pfam00083 50 LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISE 129
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 782731598 136 VFPGRLLGRILGLHALLIASSSAIGPVLG---GTILHTLSWQWLFAINVLPG 184
Cdd:pfam00083 130 IAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGLQLVPA 181
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
81-184 |
3.52e-04 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 42.71 E-value: 3.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 81 RLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIG 160
Cdd:TIGR00893 55 RFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIG 134
|
90 100
....*....|....*....|....
gi 782731598 161 PVLGGTILHTLSWQWLFAINVLPG 184
Cdd:TIGR00893 135 GPLVGWILIHFSWQWAFIIEGVLG 158
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
20-168 |
3.86e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.58 E-value: 3.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 20 RVMAAIMTTTLMGVFdgTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTS 99
Cdd:COG2211 231 LLLLLAYLLFFLALA--LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 782731598 100 LGCALAKT--PEVLIGMRVLQGIGGAATLSIAPAILRSVFP-------GRLLGRILGLHALLIASSSAIGPVLGGTIL 168
Cdd:COG2211 309 LLLFFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
75-180 |
3.91e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 42.59 E-value: 3.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 75 FAALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGIGgaATLSIAPAILRSVFPGRLLGRILGLHALLIA 154
Cdd:cd17472 52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG--AISSVVMALLADLTREENRTKAMALIGASIG 129
|
90 100
....*....|....*....|....*.
gi 782731598 155 SSSAIGPVLGGTILHTLSWQWLFAIN 180
Cdd:cd17472 130 IAFAISMVLGPLLAAHLGVSGLFLIT 155
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
42-272 |
5.07e-04 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 42.35 E-value: 5.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 42 ALPSMAQKMQVPASYAVwFANGYLLAAAMTLAIFAALAARLGYRP-VFLAGLTTFTLTSLGCALAKTPEVLIGMRVLqgi 120
Cdd:pfam06609 66 ALPNILQDIGQSENQGL-FSTLWTMGQAVSILMMGRLTDRFGRRPfVIATHIIGLVGAIVGCTANKFNTLLAAMTLL--- 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 121 GGAAtlsiAPAILRSVFPGRLLGRILGLHALLIAS-----SSAIGPVLGGTILHTLSWQWLFAINVLPGTLALLLAVK-- 193
Cdd:pfam06609 142 GVAA----GPAGASPLFIGELMSNKTKFLGLLIVSaptiaMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIwy 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 194 ALPRDA------VRKQ---APFDTLGAIL-----SALLLG-STIVAANSLHDATYHTGsLCWTVLAALSGMAFIWQIRRT 258
Cdd:pfam06609 218 HPPSFAqlhgkkARKRdelAKLDWIGIFLviagtSLFLLGvSWGGKPNNPWNSAKIIG-LISSGAGSLVIFALYEVFGKP 296
|
250
....*....|....
gi 782731598 259 DNPLLPPAIFKNER 272
Cdd:pfam06609 297 EQPIIPPALFKDTR 310
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
16-179 |
5.87e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.15 E-value: 5.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 16 PTRARVMAAIMTTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTF 95
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 96 TLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPgRLLGRILGLHALLIASSSAIGPVLGGTILH---TLS 172
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLS 162
|
....*..
gi 782731598 173 WQWLFAI 179
Cdd:COG0738 163 WHLPYLI 169
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
277-424 |
1.05e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.25 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 277 ALTSMIAFVSQGITFIALPFLFQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVISTLGLMIFVVGLILLAt 356
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL- 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 782731598 357 lpASPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVGVLLA 424
Cdd:pfam07690 81 --FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS 146
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
65-184 |
2.36e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 39.86 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 65 LLAAAMTLAIFA-ALAARLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLG 143
Cdd:cd17315 43 LLLGAAIGSLFGgPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRG 122
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 782731598 144 RILGLHALLIA----SSSAIGPVLGGTILHtlSWQWLFAINVLPG 184
Cdd:cd17315 123 ALGTLNQLMITfgilLAYLLGLALSLSPPG--WWRLMFALAAVPA 165
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
63-180 |
4.18e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 4.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 63 GYLLAAAMTLAIFAALAA-----RLGYRPVFLAGLTTFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVF 137
Cdd:cd17329 38 GLVLALSAVAGIVASLIGgrladRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVT 117
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 782731598 138 PGRLLGRILGLHALLIASSSAIGPVLGGTILhTLSWQWLFAIN 180
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAA 159
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
30-179 |
6.51e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.71 E-value: 6.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 30 LMGVFDGTMINIALPSMAQKM-QVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAKTP 108
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS 294
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 782731598 109 -EVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVLGGTIL-HTLSWQWLFAI 179
Cdd:COG2223 295 lWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLdATGSYTAAFLV 367
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-161 |
6.51e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 6.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 18 RARVMAAIMTTTLMGVFDGTMINIALPSMAQKMQVPASYAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTL 97
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 782731598 98 TSLGCALA---KTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGP 161
Cdd:pfam07690 278 AALGLLLLsltLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
16-217 |
7.43e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 38.58 E-value: 7.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 16 PTRARVMAAIMTTTLMGVFDGTMINIALP-SMAQKMQVPASYAvwfangyLLAAAMTLAIF------AALAARLGYRPVF 88
Cdd:pfam05977 6 PLRQGVFRVIWIASLASNLGTLMQDVAASwLMTSLSASPLMVA-------LVQAAATLPIFllsipaGALADNFDRRKIM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 89 LAG-----LTTFTLTSLGCALAKTPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGLHALLIASSSAIGPVL 163
Cdd:pfam05977 79 LAGqlllaLVSTLLTLLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPAL 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 782731598 164 GGTILHTLSWQWLFAINVLpGTLALLLAVKALPRDAVRKQAPFDTLGAILSALL 217
Cdd:pfam05977 159 GGVLLAAFGPAFTFALNAL-SYFAVIAALWRWKRAAPASPLPRERIFGAVRAGL 211
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
273-425 |
9.73e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 37.93 E-value: 9.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782731598 273 FTLAALTSMIAFVSQGITFIALPFLfQSEYGYSPVISALLFTPWPLGIVLIAPHAGRWADTISAPVISTLGLMIFVVGLI 352
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPL-QADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 782731598 353 LLATlpaSPSMWDICLRSLVCGMGFGCFQSPNNREMLSNVSRDYASYASGVLSIMRTFGQCLGAAAVGVLLAT 425
Cdd:COG2271 91 LFGF---ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
|
| |
