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Conserved domains on  [gi|782717478|ref|WP_045617594|]
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MULTISPECIES: antirestriction protein ArdA [Enterobacteriaceae]

Protein Classification

antirestriction protein ArdA( domain architecture ID 10008776)

antirestriction protein ArdA allows associated mobile genetic elements to evade the ubiquitous Type I DNA restriction systems, assisting in the spread of resistance genes in bacteria

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArdA COG4734
Antirestriction protein ArdA [Defense mechanisms];
1-166 5.41e-57

Antirestriction protein ArdA [Defense mechanisms];


:

Pssm-ID: 443768  Cd Length: 173  Bit Score: 176.28  E-value: 5.41e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782717478   1 MNTTTPAIYVGTYHKYNCGSLYGKWFDLTDfdDKAEFLEACYDLHSN---ESDPELMFQDWEGIPSAFASESSVDWNFIE 77
Cdd:COG4734    3 TTETTPRIYVACLAAYNNGSLHGKWIDATQ--DVEEIQEAIREMLADspvEDAEEWAIHDYEGFPGATISEYESLEKVFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782717478  78 AYKRAVEdgMDAAFIAWVEYSG--ECDYKAFEDAYCGEAESEEDYAWTMAEECGLLNDIPESLRCYFDMGAWARDLFLDG 155
Cdd:COG4734   81 LAEFIEE--HGEAFAAWLDHFGglEDAEEAFEDAYQGEYDSEADFAEELIEETGLLLEIPESLARYIDYEAYARDLFLSD 158

                        170
                 ....*....|....*
gi 782717478 156 LVFLDG----YVFNG 166
Cdd:COG4734  159 YVTVEGgfevHVFWN 173
 
Name Accession Description Interval E-value
ArdA COG4734
Antirestriction protein ArdA [Defense mechanisms];
1-166 5.41e-57

Antirestriction protein ArdA [Defense mechanisms];


Pssm-ID: 443768  Cd Length: 173  Bit Score: 176.28  E-value: 5.41e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782717478   1 MNTTTPAIYVGTYHKYNCGSLYGKWFDLTDfdDKAEFLEACYDLHSN---ESDPELMFQDWEGIPSAFASESSVDWNFIE 77
Cdd:COG4734    3 TTETTPRIYVACLAAYNNGSLHGKWIDATQ--DVEEIQEAIREMLADspvEDAEEWAIHDYEGFPGATISEYESLEKVFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782717478  78 AYKRAVEdgMDAAFIAWVEYSG--ECDYKAFEDAYCGEAESEEDYAWTMAEECGLLNDIPESLRCYFDMGAWARDLFLDG 155
Cdd:COG4734   81 LAEFIEE--HGEAFAAWLDHFGglEDAEEAFEDAYQGEYDSEADFAEELIEETGLLLEIPESLARYIDYEAYARDLFLSD 158

                        170
                 ....*....|....*
gi 782717478 156 LVFLDG----YVFNG 166
Cdd:COG4734  159 YVTVEGgfevHVFWN 173
ArdA pfam07275
Antirestriction protein (ArdA); This family consists of several bacterial antirestriction ...
 8-164 5.40e-30

Antirestriction protein (ArdA); This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.


Pssm-ID: 462130  Cd Length: 151  Bit Score: 106.56  E-value: 5.40e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782717478    8 IYVGTYHKYNCGSLYGKWFDLTDfdDKAEFLEACYDLHSN-ESDPELMFQDWEGIPsAFASEssvdWNFIEAYKRavedg 86
Cdd:pfam07275   1 IYVANLAKYNNGELVGEWLDLPA--DAEELQEALRRIGAEgEEYEEYAIHDYEGFG-FTLGE----YESIDELNE----- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782717478   87 MDAAFIAWVEYSGECDYKAFEDAYCGEAESEE---DYAWTMAEECGLLNDIPESLRCYFDMGAWARDLFLDGLVFL--DG 161
Cdd:pfam07275  69 LAALLEELAEHDLEEFEAAFEERYAGEYDSLIqnlDYAYYYVEELGELDEIPEELENYFDYEAYGRDLFLDGDGVFteTG 148


                  ...
gi 782717478  162 YVF 164
Cdd:pfam07275 149 YVE 151
 
Name Accession Description Interval E-value
ArdA COG4734
Antirestriction protein ArdA [Defense mechanisms];
1-166 5.41e-57

Antirestriction protein ArdA [Defense mechanisms];


Pssm-ID: 443768  Cd Length: 173  Bit Score: 176.28  E-value: 5.41e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782717478   1 MNTTTPAIYVGTYHKYNCGSLYGKWFDLTDfdDKAEFLEACYDLHSN---ESDPELMFQDWEGIPSAFASESSVDWNFIE 77
Cdd:COG4734    3 TTETTPRIYVACLAAYNNGSLHGKWIDATQ--DVEEIQEAIREMLADspvEDAEEWAIHDYEGFPGATISEYESLEKVFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782717478  78 AYKRAVEdgMDAAFIAWVEYSG--ECDYKAFEDAYCGEAESEEDYAWTMAEECGLLNDIPESLRCYFDMGAWARDLFLDG 155
Cdd:COG4734   81 LAEFIEE--HGEAFAAWLDHFGglEDAEEAFEDAYQGEYDSEADFAEELIEETGLLLEIPESLARYIDYEAYARDLFLSD 158

                        170
                 ....*....|....*
gi 782717478 156 LVFLDG----YVFNG 166
Cdd:COG4734  159 YVTVEGgfevHVFWN 173
ArdA pfam07275
Antirestriction protein (ArdA); This family consists of several bacterial antirestriction ...
 8-164 5.40e-30

Antirestriction protein (ArdA); This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.


Pssm-ID: 462130  Cd Length: 151  Bit Score: 106.56  E-value: 5.40e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782717478    8 IYVGTYHKYNCGSLYGKWFDLTDfdDKAEFLEACYDLHSN-ESDPELMFQDWEGIPsAFASEssvdWNFIEAYKRavedg 86
Cdd:pfam07275   1 IYVANLAKYNNGELVGEWLDLPA--DAEELQEALRRIGAEgEEYEEYAIHDYEGFG-FTLGE----YESIDELNE----- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782717478   87 MDAAFIAWVEYSGECDYKAFEDAYCGEAESEE---DYAWTMAEECGLLNDIPESLRCYFDMGAWARDLFLDGLVFL--DG 161
Cdd:pfam07275  69 LAALLEELAEHDLEEFEAAFEERYAGEYDSLIqnlDYAYYYVEELGELDEIPEELENYFDYEAYGRDLFLDGDGVFteTG 148


                  ...
gi 782717478  162 YVF 164
Cdd:pfam07275 149 YVE 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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