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Conserved domains on  [gi|779897369|ref|WP_045370603|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Vibrio]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10601889)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 11-68 2.02e-04

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


:

Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 38.29  E-value: 2.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 779897369   11 LKRQLKLSGLHYVDVAQHLELSEGSVKRLLA-EGSQISLDRLERICQLIGLEMAELFKL 68
Cdd:pfam13443   2 LRKLMADRGISKSDLARATGISRATLSRLRKgKPKRVSLDTLDKICDALGCQPGDLLEY 60
 
Name Accession Description Interval E-value
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 11-68 2.02e-04

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 38.29  E-value: 2.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 779897369   11 LKRQLKLSGLHYVDVAQHLELSEGSVKRLLA-EGSQISLDRLERICQLIGLEMAELFKL 68
Cdd:pfam13443   2 LRKLMADRGISKSDLARATGISRATLSRLRKgKPKRVSLDTLDKICDALGCQPGDLLEY 60
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 9-65 1.56e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.99  E-value: 1.56e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 779897369   9 KELKRQLKLSGLHYVDVAQHLELSEGSVKRLLAEGSQISLDRLERICQLIGLEMAEL 65
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
7-67 4.32e-03

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 34.73  E-value: 4.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 779897369   7 LIKELKRQLKLSGLHYVDVAQHLELSEGSVKRLLA-EGSQISLDRLERICQLIGLEMAELFK 67
Cdd:COG3655    2 IYVKLDELLAERGMTKKELAEATGISRATLSRLKNgKAKAVRLDTLEKICKALDCQPGDLLE 63
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
10-65 4.70e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 34.42  E-value: 4.70e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 779897369    10 ELKRQLKLSGLHYVDVAQHLELSEGSVKRLLAEGSQISLDRLERICQLIGLEMAEL 65
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
 
Name Accession Description Interval E-value
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 11-68 2.02e-04

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 38.29  E-value: 2.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 779897369   11 LKRQLKLSGLHYVDVAQHLELSEGSVKRLLA-EGSQISLDRLERICQLIGLEMAELFKL 68
Cdd:pfam13443   2 LRKLMADRGISKSDLARATGISRATLSRLRKgKPKRVSLDTLDKICDALGCQPGDLLEY 60
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 9-65 1.56e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.99  E-value: 1.56e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 779897369   9 KELKRQLKLSGLHYVDVAQHLELSEGSVKRLLAEGSQISLDRLERICQLIGLEMAEL 65
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
7-67 4.32e-03

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 34.73  E-value: 4.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 779897369   7 LIKELKRQLKLSGLHYVDVAQHLELSEGSVKRLLA-EGSQISLDRLERICQLIGLEMAELFK 67
Cdd:COG3655    2 IYVKLDELLAERGMTKKELAEATGISRATLSRLKNgKAKAVRLDTLEKICKALDCQPGDLLE 63
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
10-65 4.70e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 34.42  E-value: 4.70e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 779897369    10 ELKRQLKLSGLHYVDVAQHLELSEGSVKRLLAEGSQISLDRLERICQLIGLEMAEL 65
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-67 9.26e-03

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 34.20  E-value: 9.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 779897369   1 MSESHDLIKE-LKRQLKLSGLHYVDVAQHLELSEGSVKRLLAEGSQISLDRLERICQLIGLEMAELFK 67
Cdd:COG1396    1 MSTLKKALGErLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLG 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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