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Conserved domains on  [gi|765442311|ref|WP_044702262|]
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MULTISPECIES: addiction module antidote protein [Citrobacter]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 366238)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family; HTH domain binds DNA and may function as a transcriptional regulator

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_XRE super family cl22854
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 3-91 3.72e-38

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


The actual alignment was detected with superfamily member TIGR02684:

Pssm-ID: 473980  Cd Length: 89  Bit Score: 122.44  E-value: 3.72e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765442311   3 KLTQYDPAVALVDDEEIAVFMADALETGDATYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAVMK 82
Cdd:TIGR02684  1 KLAEFDPAEYLKTEEAIAEYLAQAFEDGDPAYIAHALGYIARARGMTQLAKKTGLSRESLYKALSGKGNPTFDTILKVTK 80


                 ....*....
gi 765442311  83 ALGIGLTVK 91
Cdd:TIGR02684 81 ALGLKLTAK 89
 
Name Accession Description Interval E-value
dnstrm_HI1420 TIGR02684
probable addiction module antidote protein; Members of this strictly bacterial protein family ...
 3-91 3.72e-38

probable addiction module antidote protein; Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the downstream member of a gene pair. It is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, are located often with prophage regions, but also both in integrated plasmid regions and in housekeeping gene regions. Analysis suggests that the gene pair may serve as an addiction module. [Mobile and extrachromosomal element functions, Other]


Pssm-ID: 188241  Cd Length: 89  Bit Score: 122.44  E-value: 3.72e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765442311   3 KLTQYDPAVALVDDEEIAVFMADALETGDATYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAVMK 82
Cdd:TIGR02684  1 KLAEFDPAEYLKTEEAIAEYLAQAFEDGDPAYIAHALGYIARARGMTQLAKKTGLSRESLYKALSGKGNPTFDTILKVTK 80


                 ....*....
gi 765442311  83 ALGIGLTVK 91
Cdd:TIGR02684 81 ALGLKLTAK 89
PA5055 COG3636
Uncharacterized Zn-binding protein, DUF971 domain [Mobilome: prophages, transposons];
1-90 4.97e-37

Uncharacterized Zn-binding protein, DUF971 domain [Mobilome: prophages, transposons];


Pssm-ID: 442853  Cd Length: 92  Bit Score: 119.50  E-value: 4.97e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765442311  1 MNKLTQYDPAVALVDDEEIAVFMADALETGDATYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV 80
Cdd:COG3636   3 KTKLRDFDLAEYLKDPEDAAAYLNAALEEGDPAELLAALGDVARARGMSQLAKEAGLSRESLYKALSPKGNPTLDTLLKV 82

                        90
                ....*....|
gi 765442311 81 MKALGIGLTV 90
Cdd:COG3636  83 LKALGLRLTV 92
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 49-70 7.65e-03

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 33.85  E-value: 7.65e-03
                         10        20
                 ....*....|....*....|..
gi 765442311  49 ANIAAETGLSREQLYRSFSEKG 70
Cdd:PRK09685 218 EWIAGELGISVRSLYRLFAEQG 239
 
Name Accession Description Interval E-value
dnstrm_HI1420 TIGR02684
probable addiction module antidote protein; Members of this strictly bacterial protein family ...
 3-91 3.72e-38

probable addiction module antidote protein; Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the downstream member of a gene pair. It is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, are located often with prophage regions, but also both in integrated plasmid regions and in housekeeping gene regions. Analysis suggests that the gene pair may serve as an addiction module. [Mobile and extrachromosomal element functions, Other]


Pssm-ID: 188241  Cd Length: 89  Bit Score: 122.44  E-value: 3.72e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765442311   3 KLTQYDPAVALVDDEEIAVFMADALETGDATYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAVMK 82
Cdd:TIGR02684  1 KLAEFDPAEYLKTEEAIAEYLAQAFEDGDPAYIAHALGYIARARGMTQLAKKTGLSRESLYKALSGKGNPTFDTILKVTK 80


                 ....*....
gi 765442311  83 ALGIGLTVK 91
Cdd:TIGR02684 81 ALGLKLTAK 89
PA5055 COG3636
Uncharacterized Zn-binding protein, DUF971 domain [Mobilome: prophages, transposons];
1-90 4.97e-37

Uncharacterized Zn-binding protein, DUF971 domain [Mobilome: prophages, transposons];


Pssm-ID: 442853  Cd Length: 92  Bit Score: 119.50  E-value: 4.97e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765442311  1 MNKLTQYDPAVALVDDEEIAVFMADALETGDATYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV 80
Cdd:COG3636   3 KTKLRDFDLAEYLKDPEDAAAYLNAALEEGDPAELLAALGDVARARGMSQLAKEAGLSRESLYKALSPKGNPTLDTLLKV 82

                        90
                ....*....|
gi 765442311 81 MKALGIGLTV 90
Cdd:COG3636  83 LKALGLRLTV 92
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 49-70 7.65e-03

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 33.85  E-value: 7.65e-03
                         10        20
                 ....*....|....*....|..
gi 765442311  49 ANIAAETGLSREQLYRSFSEKG 70
Cdd:PRK09685 218 EWIAGELGISVRSLYRLFAEQG 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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