|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
9-1065 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1055.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 9 PDGRTPASPRFPEIERRILAYWDEDGTFQASIDQRPTRNEdgsqneFVFYDGPPFANGLPHYGHLLTGYVKDLVARYQTQ 88
Cdd:COG0060 8 PKTDFPMRANLPKREPEILKFWEENDIYEKSREARAGRPK------FVLHDGPPYANGDIHIGHALNKILKDIIVRYKTM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 89 QGRRVERRFGWDTHGLPAELEAMKQLGMTdKSEIEAMGIDTFNDACRSSVLKYTDQWQDYVTRQARWVDFENDYKTLTPD 168
Cdd:COG0060 82 RGFDVPYVPGWDCHGLPIELKVEKELGIK-KKDIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 169 FMESVIWAFSELHRKGLTYRGFRVLPYCWNDETPLSNHELrmdddVYKMRQDPSVTVTFPITGLPADPALVPdggadaal 248
Cdd:COG0060 161 YEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEV-----EYKDVTSPSIYVKFPVKDEKALLLLED-------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 249 aahlagVHVL----------AwtttpwtlptNAALAVGPQIQYAVVpagpegATADGDRFLLAVDLVGAHARELGYadad 318
Cdd:COG0060 228 ------AYLViwtttpwtlpA----------NLAVAVHPDIDYVLV------EVTGGERLILAEALVEAVLKELGI---- 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 319 aARAAVTETIPGARLGGLAYAPLFTDVfdahrgetftvngrdLGVEGAHRILVDDYVSTEDGTGVVHQAPAYGEDDQRVC 398
Cdd:COG0060 282 -EDYEVLATFKGAELEGLRYEHPFYYV---------------VGYDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVG 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 399 EANGIPVLLSVDSGARFLplfarEDVGrgdlrEIAGVQVFEANRTIIRALRALGRVAREASYEHSYPHCWRCRTPLIYRA 478
Cdd:COG0060 346 KKYGLPVLNPVDDDGRFT-----EEAP-----LFAGLFVKDANPAIIEDLKERGALLAREKITHSYPHCWRCKTPLIYRA 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 479 VTSWYVKVTQIKERMLELNEEITWIPGNvKHGQFGTWVANARDWSISRNRYWGSPIPVWESDHPDFP--RQEVYGSLAEI 556
Cdd:COG0060 416 TPQWFISMDKLRDRALEAIEKVNWIPEW-GEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDCGELhrTEEVIGSVAEL 494
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 557 EEAFGrlpRNAQGEVDLHRPWVDDlTRPHPDpeaaaAGAVMRRVEDVLDVWFDSGSMPYAQVHypfERADwfpTHNPADF 636
Cdd:COG0060 495 LEEEG---ADAWFELDLHRPFLDE-TLKCPK-----CGGTMRRVPDVLDVWFDSGSMHFAVLE---NREE---LHFPADF 559
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 637 IVEYIGQTRGWFYTMHILATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFLMASPilRGG 716
Cdd:COG0060 560 YLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVASSD--YWG 637
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 717 NLIVTEEGIREgVRQVLLPAWNAYHFFTlyANTahdggarpDGYRAQERHTAED---PLDQYILAATGRMLREVKTSLDA 793
Cdd:COG0060 638 DLRFSDEILKE-VRDVYRRLRNTYRFLL--ANL--------DDFDPAEDAVPYEdlpELDRWILSRLNELIKEVTEAYDN 706
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 794 YEVSDATDALRGFM-DTLTNWYIRRSRERFFDEDT------VAFDVLYTVLEAFARAAAPLMPLIAEEIWRGLTGGR--S 864
Cdd:COG0060 707 YDFHRAYRALHNFCvEDLSNWYLDISKDRLYTEAAdsldrrAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPGEAeeS 786
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 865 VHLTDYPDADLFPHGPEadsLVARMDAVRRISSAGS----ALRKgAGrRVRLPLPRLSVVVPDAAGLEG--TYARIVADE 938
Cdd:COG0060 787 VHLADWPEVDEELIDEE---LEAKWDLVREVRSAVLkaleAARK-EK-LIRQPLEAAVVLYADEELAAAleSLGDLLAEE 861
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 939 LNLKDVELTELSEeaiarygigtelklnfrelgkafgrqvPLVKQAVDAGAYEETAEGLAVTLADGETVTlapalyELRT 1018
Cdd:COG0060 862 LNVSEVELVDDAE---------------------------DLGKDALKALDVEGISVTVEVEKADGEKCE------RCWH 908
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....*..
gi 765340689 1019 VSTGAPEgtavgvlpgtagflvldtevsaelAAEGTARDVVRAVQAA 1065
Cdd:COG0060 909 YEVGWTP------------------------EHEGLCRRCVRRVQGL 931
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
19-1101 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 837.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 19 FPEIERRILAYWDEDGTFQASIdqRPTRNEDgsqnEFVFYDGPPFANGLPHYGHLLTGYVKDLVARYQTQQGRRVERRFG 98
Cdd:PLN02882 10 FPKQEEKILSLWSEIDAFKTQL--KRTEGLP----EYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 99 WDTHGLPAELEAMKQLGMTDKSEIEAMGIDTFNDACRSSVLKYTDQWQDYVTRQARWVDFENDYKTLTPDFMESVIWAFS 178
Cdd:PLN02882 84 WDCHGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 179 ELHRKGLTYRGFRVLPYCWNDETPLSNHELRMDddvYKMRQDPSVTVTFPITGLPADPALVpdggadaalaahlagvhvl 258
Cdd:PLN02882 164 QLFEKGLVYKGFKVMPYSTACKTPLSNFEAGLN---YKDVSDPAVMVSFPIVGDPDNASFV------------------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 259 AWTTTPWTLPTNAALAVGPQIQYAVVPAGPEGAtadgdRFLLAVDLVGA------HARELGYADADAARAAVTETIPGAR 332
Cdd:PLN02882 222 AWTTTPWTLPSNLALCVNPNFTYVKVRNKYTGK-----VYIVAESRLSAlptakpKSKKGSKPENAAEGYEVLAKVPGSS 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 333 LGGLAYAPLFtDVFDAHRgetftvngrdlgvEGAHRILVDDYVSTEDGTGVVHQAPAYGEDDQRVCEANGI-------PV 405
Cdd:PLN02882 297 LVGKKYEPLF-DYFSEFS-------------DTAFRVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIiekggnlPV 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 406 llSVDSGARFLplfarEDVGrgdlrEIAGVQVFEANRTIIRALRALGRVAREASYEHSYPHCWRCRTPLIYRAVTSWYVK 485
Cdd:PLN02882 363 --PVDDDGCFT-----EKVT-----DFSGRYVKDADKDIIAAIKAKGRLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVK 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 486 VTQIKERMLELNEEITWIPGNVKHGQFGTWVANARDWSISRNRYWGSPIPVWESDhpDFPRQEVYGSLAEIEEAFGRlpr 565
Cdd:PLN02882 431 VEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGTPLPIWISD--DGEEVVVIGSIAELEKLSGV--- 505
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 566 naqgEV-DLHRPWVDDLTRPHP-DPEAaaagAVMRRVEDVLDVWFDSGSMPYAQVHYPFERADWFPTHNPADFIVEYIGQ 643
Cdd:PLN02882 506 ----KVtDLHRHFIDHITIPSSrGPEF----GVLRRVDDVFDCWFESGSMPYAYIHYPFENKELFEKNFPADFVAEGLDQ 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 644 TRGWFYTMHILATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFLMASPILRGGNLIVTEE 723
Cdd:PLN02882 578 TRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLINSPVVRAEPLRFKEE 657
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 724 GIREGVRQVLLPAWNAYHFFTLYANTAH-DGGARPDGYRAQERHTAEDPLDQYILAATGRMLREVKTSLDAYEVSDATDA 802
Cdd:PLN02882 658 GVFGVVKDVFLPWYNAYRFLVQNAKRLEvEGGAPFVPLDLAKLQNSANVLDRWINSATQSLVKFVREEMGAYRLYTVVPY 737
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 803 LRGFMDTLTNWYIRRSRERFF----DEDT-VAFDVLYTVLEAFARAAAPLMPLIAEEIW----RGLTGGR-SVHLTDYPD 872
Cdd:PLN02882 738 LVKFIDNLTNIYVRFNRKRLKgrtgEEDCrTALSTLYNVLLTSCKVMAPFTPFFTEVLYqnlrKVLPGSEeSIHYCSFPQ 817
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 873 ADLFPHGPEADSLVARMdavRRISSAGSALRKGAGRRVRLPLPRLSVVVPDA---AGLEGTYARIVADELNLKDVELTel 949
Cdd:PLN02882 818 VDEGELDERIEQSVSRM---QTVIELARNIRERHNKPLKTPLKEMVVVHPDAeflDDITGKLKEYVLEELNVRSLVPC-- 892
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 950 seEAIARYgigTELKL--NFRELGKAFGRQVPLVKQAV------DAGAYEETAEglaVTLAdGETVTLAP--ALYELRTv 1019
Cdd:PLN02882 893 --NDPLKY---ASLRAepNFSVLGKRLGKSMGLVAKEVkamsqdDILEFEKAGE---VTIA-GHTLKAGDikVVRDFKR- 962
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 1020 stgaPEGTAVGVL--PGTAGFLV-LDTEVSAELAAEGTARDVVRAVQAARKDAGLDVSDRVRTRIEgPTAVVAALEAHRG 1096
Cdd:PLN02882 963 ----PEGVSKEDIdaAGDGDVLViLDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEVFFE-SLDEVDESALSQV 1037
|
....*
gi 765340689 1097 LVAEE 1101
Cdd:PLN02882 1038 LKSQA 1042
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
14-914 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 776.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 14 PASPRFPEIERRILAYWDEDGTFQASIDQRptrnedGSQNEFVFYDGPPFANGLPHYGHLLTGYVKDLVARYQTQQGRRV 93
Cdd:TIGR00392 3 PMRGNLSKREEKILAFWQENDIFEKVKKLN------KGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 94 ERRFGWDTHGLPAELEAMKQLGMTDKSEIEAMGIDTFNDACRSSVLKYTDQWQDYVTRQARWVDFENDYKTLTPDFMESV 173
Cdd:TIGR00392 77 TRKPGWDTHGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 174 IWAFSELHRKGLTYRGFRVLPYCWNDETPLSNHELRMDDDvYKMRQDPSVTVTFPITGLPADPALVPDGGadaalaahla 253
Cdd:TIGR00392 157 WWLFKEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKEN-YKDVKDPSIYVKFPVKKDKKTYLKVKLSS---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 254 gvhVLAWTTTPWTLPTNAALAVGPQIQYAVVPAGPEgatadGDRFLLAVDLVGAHARELGyadadaARAAVTETIPGARL 333
Cdd:TIGR00392 226 ---LLIWTTTPWTLPSNLAIAVHPDFEYALVQDNTK-----VEYFILAKKLVEKLYNKAG------SDYEIIKTFKGSDL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 334 GGLAYAPLFTDVfdahrgetftVNGRDlgvEGAHRILVDDYVSTEDGTGVVHQAPAYGEDDQRVCEANGIPVLLSVDSGA 413
Cdd:TIGR00392 292 EGLEYEHPLYDF----------VSQLK---EGAPVVIGGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKG 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 414 RFLPLFAREdvgRGDLREIAGVQVFEANRTIIRALRALGRVAREASYEHSYPHCWRCRTPLIYRAVTSWYVKVTQIKERM 493
Cdd:TIGR00392 359 VYTEGVNDF---QGRFVKDADKDIIKANKIIIEQLKDKGLLLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQM 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 494 LELNEEITWIPGNVkHGQFGTWVANARDWSISRNRYWGSPIPVWESDhpDFPRQEVYGSLAEIEEAFGRLPRNAQGEvDL 573
Cdd:TIGR00392 436 LEQIKKVNWVPEWG-EGRFGNWLENRPDWCISRQRYWGIPIPIWYCE--DTGEPIVVGSIEELIELIELKGIDAWFE-DL 511
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 574 HRPWVDDLTRPHPDpeaaaaGAVMRRVEDVLDVWFDSGSMPYAQVHYPFERaDWFPTHNPADFIVEYIGQTRGWFYTMHI 653
Cdd:TIGR00392 512 HRDFLDKITLKSGD------GGEYRRVPDVLDVWFDSGSMPYASIHYPFEN-EKFKEVFPADFILEGSDQTRGWFYSSLA 584
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 654 LATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFL-MASPilrGGNLIVTEEGIREGVRQV 732
Cdd:TIGR00392 585 IGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGADILRLYVaSSDP---WEDLRFSDEILKQVVEKY 661
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 733 LLPAWNAYHFFTLYANTahDGGARPDGYRAQERHTaedPLDQYILAATGRMLREVKTSLDAYEVSDATDALRGFMD-TLT 811
Cdd:TIGR00392 662 RKIRWNTYRFLLTYANL--DKFDPLFNSVAVEKFP---EEDRWILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVeELS 736
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 812 NWYIRRSRERFFDEDTV-----AFDVLYTVLEAFARAAAPLMPLIAEEIWRGLTGG---RSVHLTDYPDADlfpHGPEAD 883
Cdd:TIGR00392 737 NWYIRIIRDRLYCEAKDndkraAQTTLYYALLTLVRLLAPFLPHTAEEIYQNLPGGeeeESVHLNLWPEVD---EEFIDE 813
|
890 900 910
....*....|....*....|....*....|.
gi 765340689 884 SLVARMDAVRRISSAGSALRKGAGRRVRLPL 914
Cdd:TIGR00392 814 ALEANMAIVREIVEAFLALRDAANKKLRQPL 844
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
16-970 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 595.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 16 SPRFPEIERRILAYWDedgtfqaSIDQRPTRNE-DGSQNEFVFYDGPPFANGLPHYGHLLTGYVKDLVARYQTQQGRRVE 94
Cdd:PTZ00427 71 NPNIVEEEEKVLKYWK-------SIDAFNTSNKlAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 95 RRFGWDTHGLPAELEAMKQLGMTDKSEIEAMGIDTFNDACRSSVLKYTDQWQDYVTRQARWVDFENDYKTLTPDFMESVI 174
Cdd:PTZ00427 144 RKFGWDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVW 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 175 WAFSELHRKGLTYRGFRVLPYCWNDETPLSNHELRMDddvYKMRQDPSVTVTFPI-TGLPADPALVPDGGADAALAAHLA 253
Cdd:PTZ00427 224 WVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNLN---YKDTPDPSIIISFVLcSDFPKVEEECNIEEDKQLLGEKYS 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 254 GVH-------------------------VLAWTTTPWTLPTNAALAVGPQIQYAVVpagpegATADGDR-FLLAVDLVGA 307
Cdd:PTZ00427 301 VLYnnkrensnngnnnstnnvcyaqhseILAWTTTPWTLPSNLALCVNEHFTYLRI------HHVKSNRvVIVGECRLEW 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 308 HARELGYADADAAraaVTETIPGARLGGLAYAPLFTDVFDAHRGEtftvngrdlgvEGAHRILVDDYVSTEDGTGVVHQA 387
Cdd:PTZ00427 375 IMKELKWNVEDLK---IVNRFKGKELKGLRYKPLFTNFYEKYNFK-----------ERAYKILADDFVTDDAGTGIVHCA 440
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 388 PAYGEDDQRVCEANGI--P----VLLSVDSGARFlplfaredvgRGDLREIAGVQVFEANRTIIRALRALGRVAREASYE 461
Cdd:PTZ00427 441 PTYGEDDFRVCKKNGVidPekniFIDPLDANGYF----------TNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIV 510
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 462 HSYPHCWRCRTPLIYRAVTSWYVKVTQIKERMLELNEEITWIPGNVKHGQFGTWVANARDWSISRNRYWGSPIPVWESDh 541
Cdd:PTZ00427 511 HSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADE- 589
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 542 pdfpRQEVY---GSLAEIEEAFGrlPRNAQgevDLHRPWVDDLTRPHPDPEAAAAgavMRRVEDVLDVWFDSGSMPYAQV 618
Cdd:PTZ00427 590 ----KMETVicvESIKHLEELSG--VKNIN---DLHRHFIDHIEIKNPKGKTYPK---LKRIPEVFDCWFESGSMPYAKV 657
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 619 HYPF--ERADWfptHN--PADFIVEYIGQTRGWFYTMHILATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYPDVTEV 694
Cdd:PTZ00427 658 HYPFstEKEDF---HKifPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYI 734
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 695 LDRDGADAMRWFLMASPILRGGNLIVTEEGIREGVRQVLLPAWNAYHFFTLYANTAHDGGARPDGYRAQERHTAEDPLDQ 774
Cdd:PTZ00427 735 LDKYGADSLRLYLINSVAVRAENLKFQEKGVNEVVKSFILPFYHSFRFFSQEVTRYECLNKKQFLFNTDYIYKNDNIMDQ 814
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 775 YILAATGRMLREVKTSLDAYEVSDATDALRGFMDTLTNWYIRRSRER----FFDEDTV-AFDVLYTVLEAFARAAAPLMP 849
Cdd:PTZ00427 815 WIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRDRmrgsLGEENCLqSLCTTYRTLHLFTVLMAPFTP 894
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 850 LIAEEIWRGL--------------TGG------------RSVHLTDYPDAD-LFPHGPEADSLVARMDAVRRISSAGSAL 902
Cdd:PTZ00427 895 FITEYIYQQLrrvkstnehnenneTGNtkegdlnrgvihKSVHFIMLPQVDeKYIIDYEIIELIEKMKDVILLGRVLRER 974
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 765340689 903 RKGAGRRvrlPLPRLSVVVPDAAGLEgTYARI---VADELNLKDVELTE----LSEEAIARYG-IGTELKLNFREL 970
Cdd:PTZ00427 975 RKVASKK---PLKSITILHPNESYFK-NFDQIsnyIKEELNVLNVECSNdtscLDFSAIPNYKtLGVKLGYNLKKV 1046
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
26-718 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 555.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 26 ILAYWDEDGTFQasidqrPTRNEDGSQNEFVFYDGPPFANGLPHYGHLLTGYVKDLVARYQTQQGRRVERRFGWDTHGLP 105
Cdd:pfam00133 2 IYEFWDEQGYFK------PELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 106 AELEAMKQLGMTDKSEIEAMGIDTFNDACRSSVLKYTDQWQDYVTRQARWVDFENDYKTLTPDFMESVIWAFSELHRKGL 185
Cdd:pfam00133 76 TEQVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 186 TYRGFRVLPYCWNDETPLSNHELRmdddvYKMRQDPSVTVTFPITGLPAdpalvpdggadaalaahlagVHVLAWTTTPW 265
Cdd:pfam00133 156 IYRGKKLVNWSPALNTALSNLEVE-----YKDVKGPSIHVAFPLADDEG--------------------ASLVIWTTTPW 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 266 TLPTNAALAVGPQIQYAVvpagpegataDGDRFLLAVDLVGAHARELgyadadaARAAVTETIPGARLGGLAYAPLFtdv 345
Cdd:pfam00133 211 TLPGNTAVAVNPEFDYVI----------TGEGYILAEALLKSLYKKG-------TDKKILEDFRGKELEGKEAIHPF--- 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 346 fdahrgetftvngrdlgVEGAHRILVDDYVSTEDGTGVVHQAPAYGEDDQRVCEANGIPVLLSVDSGARFlplfaREDVG 425
Cdd:pfam00133 271 -----------------VNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDDGTF-----TEEAP 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 426 rgdlrEIAGVQVFEANRTIIRALRALGRVAREASYEHSYPHCWRCRTPLIYRAVTSWYVKVTQIKERMLELNEEITWIPg 505
Cdd:pfam00133 329 -----DFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVEKVQFVP- 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 506 NVKHGQFGTWVANARDWSISRNRYWGSPIPVWESDhpDFprQEVYGSLAEIEEAFGRLPRNAQgEVDLHRPWVDDLTRPh 585
Cdd:pfam00133 403 KSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSK--DT--EEVVCRGELFELVAGRFEEEGS-IKWLHREAKDKLGYG- 476
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 586 pdpeaaaaGAVMRRVEDVLDVWFDSGSMPYAQVHYPFERADWFPTHNPADFIVEYIGQTRGWFYTMHILATALFDRPAFS 665
Cdd:pfam00133 477 --------KGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFK 548
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 765340689 666 HVISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFLMASPILRGGNL 718
Cdd:pfam00133 549 NVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINL 601
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
12-859 |
1.75e-93 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 321.34 E-value: 1.75e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 12 RTPASPRFPEIERrilaYWDEDGTFQASIDqrptRNEDGSqneFVFYDGPPFANGLPHYGHLLTGYVKDLVARYQTQQGR 91
Cdd:PLN02843 2 RANSVTREPEIQK----LWEENQVYKRVSD----RNNGES---FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 92 RVERRFGWDTHGLPAELEAMKQLgmtDKSEIEAMGIDTFNDACRSSVLKYTDQWQDYVTRQARWVDFENDYKTLTPDFME 171
Cdd:PLN02843 71 KVHYVPGWDCHGLPIELKVLQSL---DQEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 172 SVIWAFSELHRKGLTYRGFRvlPYCW--NDETPLSNHELRM-DDDVYKmrqdpSVTVTFPITGLP--ADPALVPDGGADA 246
Cdd:PLN02843 148 AQIEVFGQMFLNGYIYRGRK--PVHWspSSRTALAEAELEYpEGHVSK-----SIYVAFPVVSPSetSPEELEEFLPGLS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 247 ALAAHLAGVHVLAwtttpwtlptNAALAVGPQIQYAVV------------------PAGPEGATADGDRFLLAVDLVGAH 308
Cdd:PLN02843 221 LAIWTTTPWTMPA----------NAAVAVNDKLQYSVVevqsfsedestsggnkkkRPGNVLKEQQKLFLIVATDLVPAL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 309 ARELGyadadaARAAVTETIPGARLGGLAYA-PLftdvfdahrgetftvNGRDLGVegahrILVDDYVSTEDGTGVVHQA 387
Cdd:PLN02843 291 EAKWG------VKLVVLKTFPGSDLEGCRYIhPL---------------YNRESPV-----VIGGDYITTESGTGLVHTA 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 388 PAYGEDDQRVCEANGIPVLLSVDSGARFlplfaREDVGrgdlrEIAGVQVF-EANRTIIRALRALGRVAREASYEHSYPH 466
Cdd:PLN02843 345 PGHGQEDYITGLKYGLPLLSPVDDAGKF-----TEEAG-----QFSGLSVLgEGNAAVVEALDEAGSLLMEEAYGHKYPY 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 467 CWRCRTPLIYRAVTSWYVKVTQIKERMLELNEEITWIPGNVKHgQFGTWVANARDWSISRNRYWGSPIPVW---ESDHPD 543
Cdd:PLN02843 415 DWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPAQGEN-RIRAMVSGRSDWCISRQRTWGVPIPVFyhvETKEPL 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 544 FPRQevygSLAEIEEAFGRLPRNAQGEVDlhrpwVDDLTrphpdPEAAAAGAVM-RRVEDVLDVWFDSGSmPYAQVHYPF 622
Cdd:PLN02843 494 MNEE----TIAHVKSIVAQKGSDAWWYMD-----VEDLL-----PEKYRDKASDyEKGTDTMDVWFDSGS-SWAGVLGSR 558
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 623 ERADWfpthnPADFIVEYIGQTRGWFYTMHILATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYPDVTEVLD--RD-- 698
Cdd:PLN02843 559 EGLSY-----PADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEggKNqk 633
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 699 -----GADAMRWFL----MASPILRGGNLIVTEEGIREGVRQVLlpawnayHFftLYANTaHDggarpdgYRAQERHTAE 769
Cdd:PLN02843 634 qepayGADVLRLWVasvdYTGDVLIGPQILKQMSDIYRKLRGTL-------RY--LLGNL-HD-------WKPDNAVPYE 696
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 770 D-P-LDQYILAATGRMLREVKTSLDAYEVSDATDALRGF-MDTLTNWYIRRSRERFFDEDTVAFD------VLYTVLEAF 840
Cdd:PLN02843 697 DlPsIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFtIVDLSNFYLDVAKDRLYVGGTTSFTrrscqtVLAAHLLSL 776
|
890
....*....|....*....
gi 765340689 841 ARAAAPLMPLIAEEIWRGL 859
Cdd:PLN02843 777 LRAIAPILPHLAEDAWQNL 795
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
473-718 |
1.61e-92 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 299.92 E-value: 1.61e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 473 PLIYRAVTSWYVKVTQIKERMLELNEEITWIPGNVKHgQFGTWVANARDWSISRNRYWGSPIPVWESDHPdfprqevygs 552
Cdd:cd00818 144 PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKN-RFGNWLENRRDWCISRQRYWGTPIPVWYCEDC---------- 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 553 laeieeafgrlprnaqGEVdlhrpwvddltrphpdpeaaaagaVMRRVEDVLDVWFDSGSMPYAQVHYPFERaDWFPTHN 632
Cdd:cd00818 213 ----------------GEV------------------------LVRRVPDVLDVWFDSGSMPYAQLHYPFEN-EDFEELF 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 633 PADFIVEYIGQTRGWFYTMHILATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFLMASPI 712
Cdd:cd00818 252 PADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSDV 331
|
....*.
gi 765340689 713 lRGGNL 718
Cdd:cd00818 332 -YAEDL 336
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
14-960 |
3.89e-81 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 282.85 E-value: 3.89e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 14 PASPRFPEIERRILAYWDEDGTFqasidqrpTRNEDGSQNEFVFYDGPPFANGLPHYGHLLtGYVK-DLVARYQTQQGRR 92
Cdd:PRK13208 7 PKKYDPEELEEKWQKIWEEEGTY--------KFDPDERKPVYSIDTPPPTVSGSLHIGHVF-SYTHtDFIARYQRMRGYN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 93 VERRFGWDTHGLPAELEAMKQLGMTdKSEIEAmgiDTFNDACR----SSVLKYTDQWQdyvtrqaRW---VDFENDYKTL 165
Cdd:PRK13208 78 VFFPQGWDDNGLPTERKVEKYYGIR-KDDISR---EEFIELCReltdEDEKKFRELWR-------RLglsVDWSLEYQTI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 166 TPDFMESVIWAFSELHRKGLTYRGFRVLPYCWNDETPLSNHELRmdddvYKMRQDPSVTVTFPI-TGLPAD-----PALV 239
Cdd:PRK13208 147 SPEYRRISQKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVE-----YREREGKLNYIKFPVeDGEEIEiattrPELL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 240 PdggadaalaahlagvhvlawtttpwtlptnA--ALAVGPqiqyavvpagpegataDGDRFllaVDLVGAHARelgyada 317
Cdd:PRK13208 222 P------------------------------AcvAVVVHP----------------DDERY---KHLVGKTAI------- 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 318 daaraavtetipgarlgglayAPLFtdvfdahrgetftvngrdlGVEgaHRILVDDYVSTEDGTGVVhQAPAYG-EDDQR 396
Cdd:PRK13208 246 ---------------------VPLF-------------------GVE--VPILADPLVDPDFGTGAV-MICTFGdKTDVT 282
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 397 VCEANGIPVLLSVDSGARFLPLFAredvgrgdlrEIAGVQVFEANRTIIRALRALGRVAREASYEHSYPHCWRCRTPLIY 476
Cdd:PRK13208 283 WWRELNLPTRIIIDEDGRMTEAAG----------KLAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEI 352
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 477 RAVTSWYVKVTQIKERMLELNEEITWIPGNVKHgQFGTWVAN-ARDWSISRNRYWGSPIPVWES---DHPDFPRQEvygs 552
Cdd:PRK13208 353 LVTRQWFIKVLDLKEELLERGKEINWYPEHMRV-RLENWIEGlNWDWCISRQRYFGTPIPVWYCkdcGHPILPDEE---- 427
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 553 laeieeafgRLPrnaqgeVDlhrPWVDDltrPHPDPEAAAAGAVMRRVEDVLDVWFDSGSMPYAQVHYPfERADWFPTHN 632
Cdd:PRK13208 428 ---------DLP------VD---PTKDE---PPGYKCPQCGSPGFEGETDVMDTWATSSITPLIVTGWE-RDEDLFEKVF 485
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 633 PADF------IVeyigqtRGW-FYTmhIL-ATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADAMR 704
Cdd:PRK13208 486 PMDLrpqghdII------RTWlFYT--ILrAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVR 557
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 705 -WFLMASPilrGGNLIVTEEGIREGvRQVLLPAWNAYHFFTLYantahdggarpDGYRAQERHTAEDPLDQYILAATGRM 783
Cdd:PRK13208 558 yWAASARL---GSDTPFDEKQVKIG-RRLLTKLWNASRFVLHF-----------SADPEPDKAEVLEPLDRWILAKLAKV 622
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 784 LREVKTSLDAYEVSDATDALRGFM-DTLTNWYIRRSRERFFDEDTVAFD-----VLYTVLEAFARAAAPLMPLIAEEIWR 857
Cdd:PRK13208 623 VEKATEALENYDFAKALEEIESFFwHVFCDDYLELVKSRAYGEDEEEEQksaryTLYTVLDTLLRLLAPFLPFITEEVWS 702
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 858 GLTGGrSVHLTDYPDADLFPHGPEA----DSLVARMDAVRRISSAgsalrkgAGRRVRLPLPRLSVVVPDAAGLEGTYAR 933
Cdd:PRK13208 703 WLYGG-SVHRASWPEPDEELIDEEDeelgELAKEILSAVRKYKSE-------AGLSLNAPLKKVEVYGPADLELLEAAEE 774
|
970 980
....*....|....*....|....*..
gi 765340689 934 IVADELNLKDVELTElSEEAIARYGIG 960
Cdd:PRK13208 775 DLKAAGNIEELELVE-GDPELEVEIIA 800
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
19-946 |
9.31e-80 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 280.02 E-value: 9.31e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 19 FPEIERRILAYWDEDGTFQAsidqrptrNEDGSQNEFVFYDGPPFANGLPHYGHLLTGYVKDLVARYQTQQGRRVERRFG 98
Cdd:TIGR00422 7 PHEVEKKWYKKWEKSGFFKP--------DGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 99 WDTHGLPAELEAMKQLGMTDKSEIeamgiDTFNDACRSSVLKYTDQWQDYVTRQAR----WVDFENDYKTLTPDFMESVI 174
Cdd:TIGR00422 79 TDHAGIATQVKVEKKLGAEGKTKH-----DLGREEFREKIWEWKEESGGTIKNQIKrlgaSLDWSRERFTMDEGLSKAVK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 175 WAFSELHRKGLTYRGFRVLPYCWNDETPLSNHELrmdddVYKMRQDPSVTVTFPITGLPADpalvpdggadaalaahlag 254
Cdd:TIGR00422 154 EAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEV-----EYKEVKGKLYYIRYPLANGSKD------------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 255 vHVLAWTTTPWTLPTNAALAVGPqiqyavvpagpegataDGDRFllaVDLVGAHARelgyadadaaraavtetipgarlg 334
Cdd:TIGR00422 210 -YLVVATTRPETMFGDTAVAVHP----------------EDERY---KHLIGKKVI------------------------ 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 335 glayAPLFtdvfdahrgetftvnGRDLgvegahRILVDDYVSTEDGTGVVHQAPAYGEDDQRVCEANGIPVLLSVDSgar 414
Cdd:TIGR00422 246 ----LPLT---------------GRKI------PIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDE--- 297
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 415 flplfaredvgRGDLREIA----GVQVFEANRTIIRALRALGRVAREASYEHSYPHCWRCRTPLIYRAVTSWYVKVTQIK 490
Cdd:TIGR00422 298 -----------DGLLNENAgkyqGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLA 366
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 491 ERMLEL--NEEITWIPGNVKHgQFGTWVANARDWSISRNRYWGSPIPVWEsdHPDFprqevygslaeieeafgrlprnaq 568
Cdd:TIGR00422 367 DKALEAaeEGEIKFVPKRMEK-RYLNWLRNIKDWCISRQLIWGHRIPVWY--CKEC------------------------ 419
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 569 GEVdlhrpWVDDLTRPHPDPEAAAAGAVMRRVEDVLDVWFDSGSMPYAQVHYPFERADwFPTHNPADFIVEYIGQTRGWF 648
Cdd:TIGR00422 420 GEV-----YVAKEEPLPDDKTNTGPSVELEQDTDVLDTWFSSSLWPFSTLGWPDETKD-LKKFYPTDLLVTGYDIIFFWV 493
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 649 YTMHILATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFLmASPILRGGNLIVTEEGIrEG 728
Cdd:TIGR00422 494 ARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTL-ASLVTPGDDINFDWKRV-ES 571
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 729 VRQVLLPAWNAYHfFTLYANTAHDGGARPDGYraqerhtaEDPLDQYILAATGRMLREVKTSLDAYEVSDATDALRGFM- 807
Cdd:TIGR00422 572 ARNFLNKLWNASR-FVLMNLSDDLELSGGEEK--------LSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIw 642
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 808 DTLTNWYIRRSRERFFDEDT----VAFDVLYTVLEAFARAAAPLMPLIAEEIWRGL-TGGRSVHLTDYPDADLFPHGPEA 882
Cdd:TIGR00422 643 NDFCDWYIELVKYRLYNGNEaekkAARDTLYYVLDKALRLLHPFMPFITEEIWQHFkEGADSIMLQSYPVVDAEFVDEEA 722
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 765340689 883 ----DSLVARMDAVRRI-SSAGSALRKGagrrvrlplprLSVVV----PDAAGLEGTYARIVADELNLKDVEL 946
Cdd:TIGR00422 723 ekafELLKEIIVSIRNLkAESNIPPNAP-----------LKVLLiyteAETAERLKLNAVDIKGAINFSEVEV 784
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
54-195 |
1.84e-73 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 247.53 E-value: 1.84e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 54 EFVFYDGPPFANGLPHYGHLLTGYVKDLVARYQTQQGRRVERRFGWDTHGLPAELEAMKQLGMTDKSEIEAMGIDTFNDA 133
Cdd:cd00818 2 EFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNAK 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 765340689 134 CRSSVLKYTDQWQDYVTRQARWVDFENDYKTLTPDFMESVIWAFSELHRKGLTYRGFRVLPY 195
Cdd:cd00818 82 CREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW 143
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
720-900 |
1.14e-60 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 205.48 E-value: 1.14e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 720 VTEEGIREGVRQVLLPAWNAYHFFTLYANTAHDGGARPDGYRAqerhtAEDPLDQYILAATGRMLREVKTSLDAYEVSDA 799
Cdd:cd07961 1 FSEKGVREVVRKVLLPLWNAYRFFVTYANLDGFDPGKDDDAVA-----SLNVLDRWILSRLNSLIKEVTEEMEAYDLYTA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 800 TDALRGFMDTLTNWYIRRSRERF----FDEDT-VAFDVLYTVLEAFARAAAPLMPLIAEEIWRGLTGG-----RSVHLTD 869
Cdd:cd07961 76 VRALLEFIDELTNWYIRRNRKRFwgeeGDDDKlAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRElgdapESVHLLD 155
|
170 180 190
....*....|....*....|....*....|.
gi 765340689 870 YPDADLFPHGPEadsLVARMDAVRRISSAGS 900
Cdd:cd07961 156 WPEVDESLIDEE---LEEAMELVREIVELGR 183
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
21-895 |
3.43e-47 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 184.04 E-value: 3.43e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 21 EIERRILAYWDEDGTFQASidqrptrNEDGSQNEFVFYDGPPFANGLPHYGHLLTGYVKDLVARYQTQQGRRVERRFGWD 100
Cdd:PRK14900 23 EVEARWYPFWQERGYFHGD-------EHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTD 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 101 THGLPAELEAMKQLGMTDKSEIEAMGIDTFndacRSSVLKYTDQWQDYVTRQARWV----DFENDYKTLTPDFMESVIWA 176
Cdd:PRK14900 96 HAGIATQMIVEKELKKTEKKSRHDLGREAF----LERVWAWKEQYGSRIGEQHKALgaslDWQRERFTMDEGLSRAVREV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 177 FSELHRKGLTYRGFRVLPYCWNDETPLSNHELRMDDdvykMRQDPSVTVTFPItglpadpalvpdggadaalaahlagvh 256
Cdd:PRK14900 172 FVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEE----AHQGELWSFAYPL--------------------------- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 257 vlawtttpwtlptnaalavgpqiqyavvpagpegatADGDRFLLavdlvgaharelgyadadaaraaVTETIPGARLGGL 336
Cdd:PRK14900 221 ------------------------------------ADGSGEIV-----------------------VATTRPETMLGDT 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 337 AYA--PLFTDVFDAH-RGETFTVNGRDLGVEgAHRILVDdyvsTEDGTGVVHQAPAYGEDDQRVCEANGIPVLLSVDSGA 413
Cdd:PRK14900 242 AVAvhPLDPRYMALHgKKVRHPITGRTFPIV-ADAILVD----PKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDG 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 414 RFlplfaREDVGRgdlreIAGVQVFEANRTIIRALRALGRVAREASYEHSYPHCWRCRTPLIYRAVTSWYVKVTQIKERM 493
Cdd:PRK14900 317 RM-----TAEAGP-----LAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPA 386
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 494 LELNEE--ITWIPGNVKHGQFGtWVANARDWSISRNRYWGSPIPVWesdhpdfprqevYGSLAEIEEAfgrlprnaqgev 571
Cdd:PRK14900 387 IEAVEQgrTRFIPEQWTNTYMA-WMRNIHDWCISRQLWWGHQIPAW------------YCPDGHVTVA------------ 441
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 572 dlhrpwvddltRPHPDPEAAAAGAVMRRVEDVLDVWFDSGSMPYAQVHYPfERADWFPTHNPADFIVEYIGQTRGWFYTM 651
Cdd:PRK14900 442 -----------RETPEACSTCGKAELRQDEDVLDTWFSSGLWPFSTMGWP-EQTDTLRTFYPTSVMETGHDIIFFWVARM 509
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 652 HILATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADAMRwFLMASPILRGGNLIVTEEGIrEGVRQ 731
Cdd:PRK14900 510 MMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALR-FTLAALTAQGRDIKLAKERI-EGYRA 587
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 732 VLLPAWNAYHFFTLyaNTAhdggarpdGYRAQERHTAEDPL---DQYILAATGRMLREVKTSLDAYEVSDATDALRGFM- 807
Cdd:PRK14900 588 FANKLWNASRFALM--NLS--------GYQERGEDPARLARtpaDRWILARLQRAVNETVEALEAFRFNDAANAVYAFVw 657
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 808 DTLTNWYIRRSRERFFDEDTVAFD----VLYTVLEAFARAAAPLMPLIAEEIWRGLTGGRSVhlTDYPDADL---FPHGP 880
Cdd:PRK14900 658 HELCDWYIELAKEALASEDPEARRsvqaVLVHCLQTSYRLLHPFMPFITEELWHVLRAQVGA--SAWADSVLaaeYPRKG 735
|
890 900
....*....|....*....|...
gi 765340689 881 EADS--------LVARMDAVRRI 895
Cdd:PRK14900 736 EADEaaeaafrpVLGIIDAVRNI 758
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
369-895 |
1.90e-46 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 180.69 E-value: 1.90e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 369 ILVDDYVSTEDGTGVVHQAPAYGEDDQRVCEANGIPVLLSVDsgarflplfarEDvgrGDLREIA----GVQVFEANRTI 444
Cdd:PRK05729 257 IIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMD-----------ED---GTINENPgeyqGLDRFEARKAI 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 445 IRALRALGRVAREASYEHSYPHCWRCRTPLIYRAVTSWYVKVTQIKERMLEL--NEEITWIPGNVKHgQFGTWVANARDW 522
Cdd:PRK05729 323 VADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAveNGEIKFVPERWEK-TYFHWMENIQDW 401
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 523 SISRNRYWGSPIPVWesdhpdfprqevYGslaeieeafgrlprnAQGEVdlhrpWVDdltrphPDPEAAAAGAVMRRVED 602
Cdd:PRK05729 402 CISRQLWWGHRIPAW------------YD---------------EDGEV-----YVG------REEPEAREKALLTQDED 443
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 603 VLDVWFDSGSmpyaqvhYPF----------ERADWFPThnpaDFIVeyigqTrG------WFYTMHILATALFDRPAFSH 666
Cdd:PRK05729 444 VLDTWFSSAL-------WPFstlgwpekteDLKRFYPT----SVLV-----T-GfdiiffWVARMIMMGLHFTGQVPFKD 506
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 667 VISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFL--MASPilrGGNLIVTEEGIrEGVRQVLLPAWNAyhffT 744
Cdd:PRK05729 507 VYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLaaLASP---GRDIRFDEERV-EGYRNFANKLWNA----S 578
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 745 LYA--NTAHDGGARPDGyraqerHTAEDPLDQYILAATGRMLREVKTSLDAYEVSDATDALRGFM-DTLTNWYIRRSRER 821
Cdd:PRK05729 579 RFVlmNLEGADVGELPD------PEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIwNEFCDWYLELAKPV 652
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 822 FFDED-TVAFDVLYTVLEAFARAAAPLMPLIAEEIWRGLTG---GRSVHLTDYPDADlfphGPEADSLVARMD------- 890
Cdd:PRK05729 653 LQEAAkRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPlgiEESIMLAPWPEAD----EAIDEAAEAEFEwlkelit 728
|
....*
gi 765340689 891 AVRRI 895
Cdd:PRK05729 729 AIRNI 733
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
369-895 |
2.40e-46 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 180.63 E-value: 2.40e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 369 ILVDDYVSTEDGTGVVHQAPAYGEDDQRVCEANGIPVLLSVDSGARFlplfaREDVGrgdlrEIAGVQVFEANRTIIRAL 448
Cdd:COG0525 256 IIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTI-----NENAG-----KYRGLDRFEARKAIVADL 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 449 RALGRVAREASYEHSYPHCWRCRT---PLIyravtS--WYVKVTQIKERMLE--LNEEITWIPGNVKHgQFGTWVANARD 521
Cdd:COG0525 326 EELGLLVKVEPHKHSVGHSDRSGTviePYL-----SdqWFVKMKPLAKPAIEavEDGEIKFVPERWEK-TYFHWMENIRD 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 522 WSISRNRYWGSPIPVWesdhpdfprqevYGslaeieeafgrlprnAQGEVdlhrpWVDdltRPHPDPEAAAAGAVMRRVE 601
Cdd:COG0525 400 WCISRQLWWGHRIPAW------------YC---------------PDGEV-----YVA---RTEPEACAKAGSVNLTQDE 444
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 602 DVLDVWFDSGSmpyaqvhYPFERADWfPTHNPaDFivEYigqtrgwFYTMHILATA---LF---------------DRPa 663
Cdd:COG0525 445 DVLDTWFSSAL-------WPFSTLGW-PEKTE-DL--KY-------FYPTSVLVTGfdiIFfwvarmimmglhftgEVP- 505
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 664 FSHVISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFL--MASPilrGGNLIVTEEGIrEGVR----QVllpaW 737
Cdd:COG0525 506 FKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLaaLASP---GRDIKFDEERV-EGYRnfanKL----W 577
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 738 NAYHFFTLyaNT-AHDGGARPDgyraqerHTAEDPLDQYILAATGRMLREVKTSLDAYEVSDATDALRGFM-DTLTNWYI 815
Cdd:COG0525 578 NASRFVLM--NLeGFDPGLDPD-------PEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVwNEFCDWYL 648
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 816 RRSRERFFDEDT----VAFDVLYTVLEAFARAAAPLMPLIAEEIWRGLT---GGRSVHLTDYPDADLFPHGPEADSLVAR 888
Cdd:COG0525 649 ELAKPRLYGGDEaakrETRATLVYVLEQILRLLHPFMPFITEEIWQKLPprkEGESIMLAPWPEADEELIDEEAEAEFEW 728
|
570
....*....|.
gi 765340689 889 M----DAVRRI 895
Cdd:COG0525 729 LkeviSAIRNI 739
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
474-710 |
5.00e-39 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 147.95 E-value: 5.00e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 474 LIY------RAVTSWYVKVTQIKERMLELNEEITWIPGNVKHgQFGTWVANARDWSISRNRYWGSPIPvwesdhpdfprq 547
Cdd:cd00668 128 LIYrgthpvRITEQWFFDMPKFKEKLLKALRRGKIVPEHVKN-RMEAWLESLLDWAISRQRYWGTPLP------------ 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 548 evygslaeieeafgrlprnaqgevdlhrpwvddltrphpdpeaaaagavmrrvEDVLDVWFDSGSMPYAQVHYPFERAdW 627
Cdd:cd00668 195 -----------------------------------------------------EDVFDVWFDSGIGPLGSLGYPEEKE-W 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 628 FPTHNPADFIVEYIGQTRGWFYTMHILATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFL 707
Cdd:cd00668 221 FKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYL 300
|
...
gi 765340689 708 MAS 710
Cdd:cd00668 301 TSL 303
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
23-893 |
7.23e-37 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 150.86 E-value: 7.23e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 23 ERRILAYWDEDGTFQASIDQrptrnedgSQNEFVFYDGPPFANGLPHYGHLLTGYVKDLVARYQTQQGRRVERRFGWDTH 102
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDR--------GGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 103 GLPAELEAMKQLGMTDKSEIEaMGIDTFNDacrsSVLKYTDQWQDYVTRQARWV----DFENDYKTLTPDFMESVIWAFS 178
Cdd:PLN02943 138 GIATQLVVEKMLASEGIKRTD-LGRDEFTK----RVWEWKEKYGGTITNQIKRLgascDWSRERFTLDEQLSRAVVEAFV 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 179 ELHRKGLTYRGFRVLPYCWNDETPLSNHELRMDDDVYKMRQdpsvtVTFPITGLPADpalvpdggadaalaahlagvHVL 258
Cdd:PLN02943 213 RLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPGTLYY-----IKYRVAGGSED--------------------FLT 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 259 AWTTTPWTLPTNAALAVGPQiqyavvpagpegatadGDRFllavdlvgaharelgyadadaaraavtetipGARLGGLAY 338
Cdd:PLN02943 268 IATTRPETLFGDVAIAVNPE----------------DDRY-------------------------------SKYIGKMAI 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 339 APLftdvfdahrgeTFtvnGRDLgvegahRILVDDYVSTEDGTGVVHQAPAYGEDDQRVCEANGIPvllsvdsgarFLPL 418
Cdd:PLN02943 301 VPM-----------TY---GRHV------PIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLP----------ILNV 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 419 FAREdvgrGDLREIAGVQVFEANRTIIRALRALGRVAREASYEHSYPHCWR---CRTPLIYRavtSWYVKVTQIKERMLE 495
Cdd:PLN02943 351 MNKD----GTLNEVAGLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRggeVIEPLVSK---QWFVTMEPLAEKALK 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 496 L--NEEITWIPGNVKHgQFGTWVANARDWSISRNRYWGSPIPVWESDHPDFprQEVYGSLAEIEEAFGRLPRNAQGEVDL 573
Cdd:PLN02943 424 AveNGELTIIPERFEK-IYNHWLSNIKDWCISRQLWWGHRIPVWYIVGKDC--EEDYIVARSAEEALEKAREKYGKDVEI 500
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 574 HRpwvddltrphpDPeaaaagavmrrveDVLDVWFDSGSMPYAQVHYPFERADWFPTHNPADFIVEYIGQTRGWFYTMHI 653
Cdd:PLN02943 501 YQ-----------DP-------------DVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPTTVLETGHDILFFWVARMVM 556
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 654 LATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFLMASPILRGGNLIVTEEGIREGVRQVL 733
Cdd:PLN02943 557 MGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLNLSTERLTSNKAFTNKL 636
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 734 lpaWNAYHFFTLYANTAHDGGARpDGYRAQERHTAED----PLDQ-YILAATGRMLREVKTSLDAYEVSDATDALRGFM- 807
Cdd:PLN02943 637 ---WNAGKFVLQNLPSQSDTSAW-EHILACKFDKEESllslPLPEcWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFw 712
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 808 DTLTNWYIRRSRERFFDEDTV-----AFDVLYTVLEAFARAAAPLMPLIAEEIWRGLTG-GRSVHLTDYPDADLfPHGPE 881
Cdd:PLN02943 713 SDFADWYIEASKTRLYHSGDNsalsrAQAVLLYVFENILKLLHPFMPFVTEELWQALPYrKEALIVSPWPQTSL-PKDLK 791
|
890
....*....|....*.
gi 765340689 882 A----DSLVARMDAVR 893
Cdd:PLN02943 792 SikrfENLQSLTRAIR 807
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
467-710 |
9.35e-37 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 143.16 E-value: 9.35e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 467 CWRCRTPLIYRAVTSWYVKVTQIKERMLEL--NEEITWIPGNVKHgQFGTWVANARDWSISRNRYWGSPIPVWESdhpdf 544
Cdd:cd00817 156 CSRSGDVIEPLLKPQWFVKVKDLAKKALEAvkEGDIKFVPERMEK-RYENWLENIRDWCISRQLWWGHRIPAWYC----- 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 545 prqevygslaeieeafgrlprNAQGEVDLHRPWVDDLTRPHPDPEAAAAGAVMRRVEDVLDVWFDSGSMPYAQVHYPfER 624
Cdd:cd00817 230 ---------------------KDGGHWVVAREEDEAIDKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWP-EE 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 625 ADWFPTHNPADFIVEyiGQ--TRGWFYTMHILATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADA 702
Cdd:cd00817 288 TKDLKKFYPTSLLVT--GHdiIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADA 365
|
....*...
gi 765340689 703 MRWFLMAS 710
Cdd:cd00817 366 LRFTLASA 373
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
4-871 |
1.52e-33 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 140.14 E-value: 1.52e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 4 LASSAPDGRTPAsprfpEIERRILAYWDEDGTFQASIDQRPTRNEdgsqNEFVFYDGPPFANGLPHYGHLLTGYVKDLVA 83
Cdd:PTZ00419 20 NISSMAASYDPK-----EVESGWYEWWEKSGFFKPAEDAKSLNSG----KKFVIVLPPPNVTGYLHIGHALTGAIQDSLI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 84 RYQTQQGRRVERRFGWDTHGLPA----ELEAMKQLGMT--DkseieaMGIDTFndacRSSVLKYTDQWQDYVTRQARW-- 155
Cdd:PTZ00419 91 RYHRMKGDETLWVPGTDHAGIATqvvvEKKLMKEENKTrhD------LGREEF----LKKVWEWKDKHGNNICNQLRRlg 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 156 --VDFENDYKTLTPDFMESVIWAFSELHRKGLTYRGFRVLPYCWNDETPLSnhelrmDDDVYKMRQDPSVTVTFPITGLP 233
Cdd:PTZ00419 161 ssLDWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAIS------DIEVEFEEIEKPTKITIPGYDKK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 234 ADpalvpdggadaalaahlagVHVLAwtttpwtlptnaalavgpQIQYAVVPAGPEgatadgdrfllavDLVGAHARelg 313
Cdd:PTZ00419 235 VE-------------------VGVLW------------------HFAYPLEDSGQE-------------EIVVATTR--- 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 314 yadadaaraavTETIpgarLGGLAYAPLFTDVFDAHRGETFTV----NGRDLGVegahrILVDDYVSTEDGTGVVHQAPA 389
Cdd:PTZ00419 262 -----------IETM----LGDVAVAVHPKDERYKKLHGKELIhpfiPDRKIPI-----IADDELVDMEFGTGAVKITPA 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 390 YGEDDQRVCEANGIPvllsvdsgarFLPLFAREDVGRGDLREIAGVQVFEANRTIIRALRALGRVAREASYEHSYPHCWR 469
Cdd:PTZ00419 322 HDPNDYEIAKRHNLP----------FINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSR 391
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 470 CRTPLIYRAVTSWYVKVTQIKERMLEL--NEEITWIPGNVKHGQFgTWVANARDWSISRNRYWGSPIP----VWESDHPD 543
Cdd:PTZ00419 392 SGDIVEPMLIPQWYVNCKDMAKRAVEAvrNGELKIIPSSHENVWY-HWLENIQDWCISRQLWWGHRIPayrvISKGPETD 470
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 544 FPRQEVYGSLAEIEEAFgrlpRNAQGEVDLhrpwvddltrphpdpeaAAAGAVMRRVEDVLDVWFDSGSMPYAQVHYPFE 623
Cdd:PTZ00419 471 PSDEEPWVVARSEEEAL----EKAKKKFGL-----------------SEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQ 529
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 624 RAD---WFPTHnpadfIVEyIGQTRGWFYT--MHILATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYPDVTEV---- 694
Cdd:PTZ00419 530 TDDlqrFFPTS-----LLE-TGSDILFFWVarMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEViegi 603
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 695 -------------LDRD--------------------GADAMRWFLMASPIL-RGGNL----IVteegireGVRQVLLPA 736
Cdd:PTZ00419 604 slqdlnqklyegnLPEKeikraielqkkefpngipecGTDALRFGLLAYTQQgRNINLdinrVV-------GYRHFCNKL 676
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 737 WNAYHFFTLYAntahdggarPDGYRAQErHTAEDPL--------DQYILAATGRMLREVKTSLDAYEVSDATDALRGF-M 807
Cdd:PTZ00419 677 WNAVKFALMKL---------LKDFNLPN-STLFKPNnveslpweDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFwL 746
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 765340689 808 DTLTNWYIRRSRERFFDEDT-----VAFDVLYTVLEAFARAAAPLMPLIAEEIWRGL----TGGRSVHLTDYP 871
Cdd:PTZ00419 747 YELCDVYLELIKPRLSKQSDgerkqHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLpnylRKSESISIAKYP 819
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
55-192 |
1.64e-31 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 125.99 E-value: 1.64e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 55 FVFYDGPPFANGLPHYGHLLTGYVKDLVARYQTQQGRRVERRFGWDTHGLPAELEAMKQLGMTDKSEIeamgIDTFNDAC 134
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW----IEEFREDP 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 765340689 135 RSSVLKYTDQWQDYVTRQARWVDFENDYKTLTPDFMESVIWAFSELHRKGLTYRGFRV 192
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP 135
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
934-1134 |
4.96e-31 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 121.04 E-value: 4.96e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 934 IVADELNLKDVELTElSEEAIARYGIgtelKLNFRELGKAFGRQVPLVKQAVDAGAYEETA---EGLAVTL-ADGETVTL 1009
Cdd:pfam19302 3 IIKEELNVKEVEFGA-DESELVEYSA----KPNFPVLGKELGKLMKAAAKEIASLNQMEIQkilDGGTLTIdVDGEEIEL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 1010 APA-LYELRTVSTG---APEGTaVGVlpgtagflVLDTEVSAELAAEGTARDVVRAVQAARKDAGLDVSDRVRTRIEGPT 1085
Cdd:pfam19302 78 TSEdLLVTRQGKEGlavANEGT-LTV--------ALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVSGNE 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 765340689 1086 AVVAALEAHRGLVAEETLTVDLELVDSGAADPRKdpADDAMKTVAVSVA 1134
Cdd:pfam19302 149 MLEAAIEKFEDYIKKETLAVEIIFNEEKEYTEVD--INGEKLKIAVEKV 195
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
18-874 |
5.69e-27 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 118.70 E-value: 5.69e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 18 RFPEIERRILAYWDEDGTFQASIDQrptrnedgsqNEFVFY--DGPPFANGLPHYGHLLTGYVKDLVARYQTQQGRRVER 95
Cdd:TIGR00396 2 NHIEIEEKWQQKWDENKTFKVTDDS----------SKPKYYilSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLH 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 96 RFGWDTHGLPAELEAMKQlgmtdkseieamGIDTfndacrssvLKYTDQWQDYVTRQARWVDFENDY----KTLTPDFME 171
Cdd:TIGR00396 72 PIGWDAFGLPAENAAIKR------------GIHP---------AKWTYENIANMKKQLQALGFSYDWdreiATCDPEYYK 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 172 SVIWAFSELHRKGLTYRGFRVLPYCWNDETPLSNHEL-------RMDDDVYK--MRQ--------------D-------P 221
Cdd:TIGR00396 131 WTQWIFLELFEKGLAYVKEADVNWCPNDGTVLANEQVdsdgrswRGDTPVEKkeLKQwflkitayaeellnDleeldhwP 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 222 S---------------VTVTFPItglpADPalvpdggadaalaahlagvhvlawtttpwtlptNAALAV---GPQ----I 279
Cdd:TIGR00396 211 EsvkemqrnwigksegVEITFKI----ADH---------------------------------DEKITVfttRPDtifgV 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 280 QY-AVVPAGP---EGATA--DGDRFLLAVDLVGAHARELgyadadaaraaVTETIPGARLGGLAYAPLftdvfdahrget 353
Cdd:TIGR00396 254 TYlALAPEHPlveKAAENnpKVAAFIKKILNKTVAERTK-----------ATKEKKGVDTGIKAIHPL------------ 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 354 ftvNGRDLgvegahRILVDDYVSTEDGTGVVHQAPAYGEDDQRVCEANGIPVLLSVDSGARFLPLFAREdVGRGDLR--- 430
Cdd:TIGR00396 311 ---TGEKI------PIWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDLSLTAAY-TEDGVLVnsg 380
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 431 EIAGVQVFEANRTIIRALRALGRVAREASYEhsyphcwrcrtpliyravtswyvkvtqikermlelneeitwipgnvkhg 510
Cdd:TIGR00396 381 EFNGLNSSEARNAIIDMLEKEGKGKRKVNYR------------------------------------------------- 411
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 511 qfgtwvanARDWSISRNRYWGSPIPVWESDHPD---FPRQEVYGSLAEIEEAFGRlprnaqGEVDL--HRPWVDDltrph 585
Cdd:TIGR00396 412 --------LRDWGFSRQRYWGEPIPIIHCEDGGvvpVPEEDLPVILPEDVVYDGD------GGSPLsrIPEWVNV----- 472
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 586 PDPEaaaAGAVMRRVEDVLDVWFDSG--SMPYAQVHYPFERAD------WFPthnpadfIVEYIGQTRgwFYTMHIL--- 654
Cdd:TIGR00396 473 TCPS---CGKPALRETDTMDTFAGSSwyYLRYLDPKNTDGPFDkekaeyWLP-------VDLYIGGIE--HAILHLLyar 540
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 655 --ATALFDRPA------FSHVISHGIVLG-------------------------------SDGQKMSKSLRNYPDVTEVL 695
Cdd:TIGR00396 541 ffHKFLRDIGYvntkepFKKLINQGMVLGfyyppngkvpadvlterdekgkdkaggelvyVGYEKMSKSKGNGIDPQEIV 620
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 696 DRDGADAMRWFLM-ASPIlrGGNLIVTEEGIrEGVRQVLLPAWNayhFFTLYANTAHDGGARPDGYRAQERHTAEDpldq 774
Cdd:TIGR00396 621 ESYGADALRLFIMfMGPI--AASLEWNESGL-EGARRFLDRVWN---LVYEITGELDAASLTVTALEEAQKELRRD---- 690
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 775 yilaatgrMLREVKTSLDAYEVSDATDALRGFMDTLTNWYIRRSRERFFDEdtvAFDVLYTVLEAFAraaaplmPLIAEE 854
Cdd:TIGR00396 691 --------VHKFLKKVTEDLEKRESFNTAISAMMELLNKLYKAKKEALMLE---YLKGFVTVLSPFA-------PHLAEE 752
|
970 980
....*....|....*....|.
gi 765340689 855 IWRGLTGGRS-VHLTDYPDAD 874
Cdd:TIGR00396 753 LWEKLGSEPFiIDNAKWPVVD 773
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
4-873 |
4.74e-26 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 116.15 E-value: 4.74e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 4 LASSAPDGRTPASprfpeIERRILAYWDEDGTFQAsidqrptrNEDGSQNEFVFYDGPPFANGLPHYGHLLTGYVKDLVA 83
Cdd:PLN02381 92 LSSQMAKQYSPSA-----VEKSWYAWWEKSGYFGA--------DAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTII 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 84 RYQTQQGRRVERRFGWDTHGLPAELEAMKQLGMTDKSEIEAMGIDTFndacRSSVLKYTDQWQDYVTRQARW----VDFE 159
Cdd:PLN02381 159 RWKRMSGYNALWVPGVDHAGIATQVVVEKKLMRERHLTRHDIGREEF----VSEVWKWKDEYGGTILNQLRRlgasLDWS 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 160 NDYKTLTPDFMESVIWAFSELHRKGLTYRGFRVLPYCWNDETPLSnhelrmDDDVYKMRQDPSVTVTFPITGLPADpalv 239
Cdd:PLN02381 235 RECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAIS------DVEVDYIDIKERTLLKVPGYDKPVE---- 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 240 pdggadaalaahlagvhvlawtttpwtlptnaalaVGPQIQYAVVPAGPEGatadgdrfllavDLVGAHARelgyadada 319
Cdd:PLN02381 305 -----------------------------------FGVLTSFAYPLEGGLG------------EIVVATTR--------- 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 320 araavTETIpgarLGGLAYAPLFTDVFDAHRGETFTV---NGRDLGVEgAHRILVDDYVstedGTGVVHQAPAYGEDDQR 396
Cdd:PLN02381 329 -----IETM----LGDTAIAIHPDDERYKHLHGKFAVhpfNGRKLPII-CDAILVDPNF----GTGAVKITPAHDPNDFE 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 397 VCEANGIpvllsvdsgaRFLPLFAreDVGRGDLR---EIAGVQVFEANRTIIRALRALGRVAREASYEHSYPHCWRCR-- 471
Cdd:PLN02381 395 VGKRHNL----------EFINIFT--DDGKINSNggsEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNdv 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 472 -TPLIYravTSWYVKVTQIKERMLEL-----NEEITWIPGNVKhGQFGTWVANARDWSISRNRYWGSPIPVWesdhpdfp 545
Cdd:PLN02381 463 vEPMIK---PQWFVNCSSMAKQALDAaidgeNKKLEFIPKQYL-AEWKRWLENIRDWCISRQLWWGHRIPAW-------- 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 546 rqevYGSLAEIEEA-FGrlprnaqgevDLHRPWVddLTRPHPDPEAAAAGAV------MRRVEDVLDVWFDSGSMPYAQV 618
Cdd:PLN02381 531 ----YVTLEDDQLKeLG----------SYNDHWV--VARNESDALLEASQKFpgkkfeLSQDPDVLDTWFSSGLFPLSVL 594
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 619 HYPFERAD---WFPT------HNPADFiveyigqtrgWFYTMHILATALFDRPAFSHVISHGIVLGSDGQKMSKSLRNYP 689
Cdd:PLN02381 595 GWPDDTDDlkaFYPTsvletgHDILFF----------WVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVI 664
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 690 DVTEVLD-----------------------------RD--------GADAMRWFLMASP---------ILRggnlIVtee 723
Cdd:PLN02381 665 DPLEVINgisleglhkrleegnldpkelvvakegqkKDfpngiaecGTDALRFALVSYTaqsdkinldILR----VV--- 737
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 724 gireGVRQVLLPAWNAYHFftlyANTAHDGGARPDgyrAQERHTAEDPLDQYILAATGRMLREVKTSLDAYEVSDATDAL 803
Cdd:PLN02381 738 ----GYRQWCNKLWNAVRF----AMSKLGDDYTPP---ATLSVETMPFSCKWILSVLNKAISKTVSSLDAYEFSDAASTV 806
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 804 RG---------FMDTLTNWYIRRSRErFFDEDTVAFDVLYTVLEAFARAAAPLMPLIAEEIW------RGLTGGRSVHLT 868
Cdd:PLN02381 807 YSwwqyqfcdvFIEAIKPYFAGDNPE-FASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWqrlpqpKDHTRKDSIMIS 885
|
....*
gi 765340689 869 DYPDA 873
Cdd:PLN02381 886 EYPSA 890
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
773-904 |
2.78e-22 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 94.01 E-value: 2.78e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 773 DQYILAATGRMLREVKTSLDAYEVSDATDALRGFM-DTLTNWYIRRSRERFF--DEDTVAFDVLYTVLEAFARAAAPLMP 849
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFwNDLSDWYLELIKDRLYgeEPDSRAQTTLYEVLETLLRLLAPFMP 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 765340689 850 LIAEEIWRGLtggrSVHLTDYPDADLFphgpEADSLVARMDAVRRISSAGSALRK 904
Cdd:pfam08264 81 FITEELWQKE----SIHLAPWPEDAEL----EEAELEEAFELRQEIVQAIRKLRS 127
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
520-874 |
1.17e-19 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 95.12 E-value: 1.17e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 520 RDWSISRNRYWGSPIPVwesdhpdfprqeVY----GSLAEIEEafgRLPrnaqgeVDLhrPWVDDLTRPHPDPEAAAA-- 593
Cdd:COG0495 420 RDWLISRQRYWGEPIPI------------IHcedcGVVPVPED---QLP------VEL--PEDVDFDPTGGSPLARAPew 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 594 --------GAVMRRVEDVLDVWFDSgS---MPYAQVHY---PF--ERAD-WFPthnpadfiVE-YIG----------QTR 645
Cdd:COG0495 477 vnvtcpkcGGPARRETDTMDTFVDS-SwyyLRYTDPHNdeaPFdpEAANyWLP--------VDqYIGgiehailhllYAR 547
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 646 gwFYTMhilatALFDR-------PaFSHVISHGIV--LGSDG------QKMSKSLRNYPDVTEVLDRDGADAMRWFLM-A 709
Cdd:COG0495 548 --FFTK-----VLRDLglvsfdeP-FKRLLTQGMVleVGKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMfA 619
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 710 SPILRGgnLIVTEEGIrEGVRQVLLPAWNAYHfftlyantAHDGGARPDgyraqerHTAEDPLDQYILAATGRMLREVKT 789
Cdd:COG0495 620 GPPERD--LEWSDSGV-EGAYRFLNRVWRLVV--------DEAEALKLD-------VADLSEADKELRRALHKTIKKVTE 681
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 790 SLDAYEVSDATDALRGFMDTLTnwyirrsreRFFDEDTVAFDVLYTVLEAFARAAAPLMPLIAEEIWRGLTGGRSVHLTD 869
Cdd:COG0495 682 DIERLRFNTAIAALMELVNALY---------KAKDSGEADRAVLREALETLVLLLAPFAPHIAEELWERLGHEGSVADAP 752
|
....*
gi 765340689 870 YPDAD 874
Cdd:COG0495 753 WPEAD 757
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
737-859 |
2.61e-18 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 82.22 E-value: 2.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 737 WNAYHFFTLYANtahdggarpDGYRAQERHTAEDPLDQYILAATGRMLREVKTSLDAYEVSDATDALRGFM-DTLTNWYI 815
Cdd:cd07962 17 WNAARFVLMNLE---------DDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwNDFCDWYL 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 765340689 816 RRSRERFFDEDT----VAFDVLYTVLEAFARAAAPLMPLIAEEIWRGL 859
Cdd:cd07962 88 ELVKPRLYGEDEeekkAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
61-207 |
4.48e-17 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 84.61 E-value: 4.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 61 PPFANGLPHYGHLLTGYVKDLVARYQTQQGRRVERRFGWDTHGLPAELEAMKQLGMTDKSEIEaMGIDTFNDACrssvLK 140
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHD-LGREEFLEKC----WE 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 765340689 141 YTDQWQDYVTRQARW----VDFENDYKTLTPDFMESVIWAFSELHRKGLTYRGFRVLPYCWNDETPLSNHE 207
Cdd:cd00817 84 WKEESGGKIREQLKRlgasVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIE 154
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
13-874 |
7.75e-16 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 82.95 E-value: 7.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 13 TPASPR---FPEIERRILAYWDEDGTFQASiDQRptrneDGSQNEFVFYDGPPFANGLP-HYGHLLtGYV-KDLVARYQT 87
Cdd:PLN02563 73 TPAAKRaypFHEIEPKWQRYWEENRTFRTP-DDV-----DTSKPKFYVLDMFPYPSGAGlHVGHPE-GYTaTDILARYKR 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 88 QQGRRVERRFGWDTHGLPAELEAMkQLGmTDKSEIEAMGIDTFNDACRSSVLKYtdqwqdyvtrqarwvDFENDYKTLTP 167
Cdd:PLN02563 146 MQGYNVLHPMGWDAFGLPAEQYAI-ETG-THPKITTLKNIARFRSQLKSLGFSY---------------DWDREISTTEP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 168 DFMESVIWAFSELHRKGLTYRGFRVLPYCWNDETPLSNHEL------RMDDDVYK--MRQdpsvtVTFPITGLpADPALv 239
Cdd:PLN02563 209 EYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVvdglseRGGHPVIRkpMRQ-----WMLKITAY-ADRLL- 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 240 pdggadaalaahlAGVHVLAWTTTPWTLPTN-AALAVGPQIQYAVVpaGPEGATAD---------GDRFLLAVDLVGAHA 309
Cdd:PLN02563 282 -------------EDLDDLDWPESIKEMQRNwIGRSEGAELDFSVL--DGEGKERDekitvyttrPDTLFGATYLVVAPE 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 310 REL-GYADADAARAAVTETIPGA-RLGGLAYAPL-------FTDVFDAHrgetfTVNGRDLgvegahRILVDDYVSTEDG 380
Cdd:PLN02563 347 HPLlSSLTTAEQKEAVEEYVDAAsRKSDLERTELqkektgvFTGSYAIN-----PATGEAI------PIWVADYVLGSYG 415
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 381 TGVVHQAPAYGEDDQRVCEANGIPVLLSVDSGArflplfaredvGRGDLREiagvQVFEANRTII----RALRALGRVAR 456
Cdd:PLN02563 416 TGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPAD-----------GNEDDAE----KAYTGEGVIVnsssSGLDINGLSSK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 457 EASyehsyphcwrcrtpliyRAVTSWYVKVTQIKERMlelneeitwipgNVKhgqfgtwvanARDWSISRNRYWGSPIPV 536
Cdd:PLN02563 481 EAA-----------------KKVIEWLEETGNGKKKV------------NYK----------LRDWLFARQRYWGEPIPV 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 537 WesdhpdFPrqEVYGSLAEIEEAfgrlprnaqgEVDLHRPWVDDLTrPHPDPEAAAAGAV-------------MRRVEDV 603
Cdd:PLN02563 522 V------FL--EDSGEPVPVPES----------DLPLTLPELDDFT-PTGTGEPPLAKAVswvntvdpssgkpARRETNT 582
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 604 LDVWfdSGSMPY-----------AQVHYPFERaDWFPTH---NPADFIVEYIGQTRGW---FYTMHILATalfdRPAFSH 666
Cdd:PLN02563 583 MPQW--AGSCWYylrfmdpknsnALVDKEKEK-YWMPVDlyvGGAEHAVLHLLYARFWhkvLYDIGVVST----KEPFQC 655
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 667 VISHGIVLG---------SDGQ---------------------------------------------KMSKSLRNYPDVT 692
Cdd:PLN02563 656 LVNQGMILGeveytafkdSDGEyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNPD 735
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 693 EVLDRDGADAMRWFLMASPILRGGNLIVTeEGIrEGVRQVLLPAWNAYhfftlyantahDGGARPDGYRAQERHTAEDPL 772
Cdd:PLN02563 736 DVVSEYGADSLRLYEMFMGPLRDSKTWST-SGV-EGVHRFLGRTWRLV-----------VGAPLPDGSFRDGTVVTDEEP 802
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 773 DQYILAATGRMLREVKTSLDAYEVSDATDALRGFMDTLTNWYiRRSRErffdedtvafdvlytVLEAFARAAAPLMPLIA 852
Cdd:PLN02563 803 SLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFTNAAYKWD-KVPRE---------------AIEPFVLLLSPYAPHLA 866
|
970 980
....*....|....*....|..
gi 765340689 853 EEIWRGLTGGRSVHLTDYPDAD 874
Cdd:PLN02563 867 EELWFRLGHSNSLAYEPWPEAN 888
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
648-874 |
8.40e-16 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 82.61 E-value: 8.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 648 FYTMHilATALFDRpafSH-----VIShGIVLgSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFLMASPILrGGNLIVTE 722
Cdd:PRK12300 547 FFIFN--HVAIFPE---EKwprgiVVN-GFVL-LEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAEL-LQDADWRE 618
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 723 EGIREGVRQVllpawnaYHFFTLYANTAHDGGARPDGYraqerhtaedpLDQYILAATGRMLREVKTSLDAYEVSDA-TD 801
Cdd:PRK12300 619 KEVESVRRQL-------ERFYELAKELIEIGGEEELRF-----------IDKWLLSRLNRIIKETTEAMESFQTRDAvQE 680
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 765340689 802 ALRGFMDTLtNWYIRRSRERffdedtvAFDVLYTVLEAFARAAAPLMPLIAEEIWRGLTGGRSVHLTDYPDAD 874
Cdd:PRK12300 681 AFYELLNDL-RWYLRRVGEA-------NNKVLREVLEIWIRLLAPFTPHLAEELWHKLGGEGFVSLEKWPEPD 745
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
465-859 |
1.54e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 77.61 E-value: 1.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 465 PHCWRCRTPLIYRAVTSWYVKVTQIKERMLELNEEITWIPGN----------VKHGQfgtwvanaRDWSISRNRY-WGSP 533
Cdd:PRK11893 142 YRCPPTGAPVEWVEEESYFFRLSKYQDKLLELYEANPDFIQPasrrnevisfVKSGL--------KDLSISRTNFdWGIP 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 534 IPvWESDHPdfprqeVYgslaeieeafgrlprnaqgeVdlhrpWVDDLTRphpdpEAAAAGAvmrrvedvldvwfdsgsm 613
Cdd:PRK11893 214 VP-GDPKHV------IY--------------------V-----WFDALTN-----YLTALGY------------------ 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 614 PYAQVHYPFERADWFPthnpADfiVEYIGQ--TR----GWfytmHILATALfDRPAFSHVISHG-IVLgsDGQKMSKSLR 686
Cdd:PRK11893 239 PDDEELLAELFNKYWP----AD--VHLIGKdiLRfhavYW----PAFLMAA-GLPLPKRVFAHGfLTL--DGEKMSKSLG 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 687 NYPDVTEVLDRDGADAMRWFLM-ASPILRGGNLivTEEGIREGVRQVLlpAWNayhfftlYANTAHDGGARPDGYRAQE- 764
Cdd:PRK11893 306 NVIDPFDLVDEYGVDAVRYFLLrEIPFGQDGDF--SREAFINRINADL--AND-------LGNLAQRTLSMIAKNFDGKv 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 765 -RHTAEDPLDQYILAATGRMLREVKTSLDAYEVSDATDALRGFMDTLtNWYIRRSR--ERFFDEDTVAFDVLYTVLEA-- 839
Cdd:PRK11893 375 pEPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALVRAA-NKYIDEQApwSLAKTDPERLATVLYTLLEVlr 453
|
410 420
....*....|....*....|.
gi 765340689 840 -FARAAAPLMPLIAEEIWRGL 859
Cdd:PRK11893 454 gIAVLLQPVMPELAAKILDQL 474
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
62-209 |
1.75e-13 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 72.95 E-value: 1.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 62 PFANGLPHYGHLLTGYVKDLVARYQTQQGRRVerRF--GWDTHGLPAELEAmKQLGMTdkseieamgidtfndacrssVL 139
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDV--LFvtGTDEHGTKIEQKA-EEEGVT--------------------PQ 65
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 765340689 140 KYTDQWQDYVTRQARWVDFENDY--KTLTPDFMESVIWAFSELHRKGLTYRGFRVLPYCWNDETPLSnhELR 209
Cdd:cd00814 66 ELCDKYHEIFKDLFKWLNISFDYfiRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP--EWR 135
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
770-898 |
3.31e-13 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 69.09 E-value: 3.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 770 DPLDQYILAATGRMLREVKTSLDAYEVSDATDALRGFM-DTLTNWY----------------IRRSrerffdedtvAFDV 832
Cdd:cd07960 43 LELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCtVDLSAFYldiikdrlycdakdslERRS----------AQTV 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 765340689 833 LYTVLEAFARAAAPLMPLIAEEIWRGLTGGR---SVHLTDYPDadlFPHGPEADSLVARMDAVRRISSA 898
Cdd:cd07960 113 LYHILDALLKLLAPILPFTAEEVWEHLPGEKkeeSVFLEDWPE---LPEEWKDEELEEKWEKLLALRDE 178
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
465-859 |
1.34e-12 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 71.68 E-value: 1.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 465 PHCWRCRTPLIYRAVTSWYVKVTQIKERMLELNEEITWIPGNVKhGQFGTWVANA-RDWSISRNRYWGspIPVwesdhPD 543
Cdd:COG0143 169 PRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENPDIQPEVR-NEVLSWLKEGlQDLSISRDFDWG--IPV-----PG 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 544 FPRQEVYgslaeieeafgrlprnaqgevdlhrpwvddltrphpdpeaaaagavmrrvedvldVWFD------SGSMPYA- 616
Cdd:COG0143 241 DPGKVFY-------------------------------------------------------VWFDaligyiSATKGYAd 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 617 QVHYPFERADWFPthNPADFIVEYIGQ--TRgwFYTmhilataLFdRPAF---------SHVISHGIVLgSDGQKMSKSL 685
Cdd:COG0143 266 DRGLPEDFEKYWP--APDTELVHFIGKdiIR--FHA-------II-WPAMlmaaglplpKKVFAHGFLT-VEGEKMSKSR 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 686 RNYPDVTEVLDRDGADAMRWFLMA-SPILRGGNLivTEEGIREGV-------------RqvllpawnayhffTLYANTAH 751
Cdd:COG0143 333 GNVIDPDDLLDRYGPDALRYYLLReVPFGQDGDF--SWEDFVARVnsdlandlgnlasR-------------TLSMIHKY 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 752 DGGARPDGyraqerhTAEDPLDQYILAATGRMLREVKTSLDAYEVSDATDALRGFMDtLTNwyirrsreRFFDE------ 825
Cdd:COG0143 398 FDGKVPEP-------GELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMALAR-AAN--------KYIDEtapwkl 461
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 765340689 826 ------DTVAfDVLYTVLEAFARAA---APLMPLIAEEIWRGL 859
Cdd:COG0143 462 akdedpERLA-TVLYTLLEALRILAillKPFLPETAEKILEQL 503
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
482-712 |
8.76e-12 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 67.66 E-value: 8.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 482 WYVKV--TQIKERMLELNEEITWIPGNVKHGQfgtwvanaRDW-SISRNRYWGSPIPvWEsdhpdfprqevygslaeiee 558
Cdd:cd00812 132 WFLKYseTEWKEKLLKDLEKLDGWPEEVRAMQ--------ENWiGCSRQRYWGTPIP-WT-------------------- 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 559 afgrlprnaqgevDLHRPWVDD------LTRPHPDPE-AAAAGAVMRRvedvldvwfdsgsmpYAQVHYPFeraDWFptH 631
Cdd:cd00812 183 -------------DTMESLSDStwyyarYTDAHNLEQpYEGDLEFDRE---------------EFEYWYPV---DIY--I 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 632 NPADFIVeyigqtrgwfytMHIL-----ATALFDRPA-----FSHVISHGIVLGsDGQKMSKSLRNYPDVTEVLDRDGAD 701
Cdd:cd00812 230 GGKEHAP------------NHLLysrfnHKALFDEGLvtdepPKGLIVQGMVLL-EGEKMSKSKGNVVTPDEAIKKYGAD 296
|
250
....*....|..
gi 765340689 702 AMRWFLM-ASPI 712
Cdd:cd00812 297 AARLYILfAAPP 308
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
460-709 |
2.61e-11 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 66.02 E-value: 2.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 460 YEHSY--PHCWRCRTPL-IYRAVTSWYVKVTQIKERMLEL---NEEITWiPGNVKHgQFGTWVANA-RDWSISR-NRYWG 531
Cdd:cd00814 115 YEGEYegLYCVSCERFLpEWREEEHYFFRLSKFQDRLLEWlekNPDFIW-PENARN-EVLSWLKEGlKDLSITRdLFDWG 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 532 spIPVwesdhPDFPRQEVYgslaeieeafgrlprnaqgevdlhrpwvddltrphpdpeaaaagavmrrvedvldVWFD-- 609
Cdd:cd00814 193 --IPV-----PLDPGKVIY-------------------------------------------------------VWFDal 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 610 ----SGSMPYAQvhyPFERADWFPTHNPAdfIVEYIGQTRGWFYTMH---ILATAlfDRPAFSHVISHGIVLgSDGQKMS 682
Cdd:cd00814 211 igyiSATGYYNE---EWGNSWWWKDGWPE--LVHFIGKDIIRFHAIYwpaMLLGA--GLPLPTRIVAHGYLT-VEGKKMS 282
|
250 260
....*....|....*....|....*..
gi 765340689 683 KSLRNYPDVTEVLDRDGADAMRWFLMA 709
Cdd:cd00814 283 KSRGNVVDPDDLLERYGADALRYYLLR 309
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
62-210 |
1.39e-10 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 64.62 E-value: 1.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 62 PFANGLPHYGHLLTGYVKDLVARYQTQQGRRVerRF--GWDTHGLPAELEAMKQlgmtdkseieamGIdtfndacrsSVL 139
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDV--LFvcGTDEHGTPIELKAEKE------------GI---------TPE 64
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 765340689 140 KYTDQWQDYVTRQARWVDFENDY--KTLTPDFMESVIWAFSELHRKGLTYRGFRVLPYCWNDETPLSNHELRM 210
Cdd:pfam09334 65 ELVDRYHEIHREDFKKFNISFDDygRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVEG 137
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
62-196 |
3.36e-09 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 59.57 E-value: 3.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 62 PFANGLPHYGHLLTgYVK-DLVARYQTQQGRRVERRFGWDTHGLPAELEAMKqLGmTDKSEIEAMGIDTFNDACRSSVLK 140
Cdd:cd00812 9 PYPSGALHVGHVRT-YTIgDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIK-IG-RDPEDWTEYNIKKMKEQLKRMGFS 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 765340689 141 YtdqwqdyvtrqarwvDFENDYKTLTPDFMESVIWAFSELHRKGLTYRGFRVLPYC 196
Cdd:cd00812 86 Y---------------DWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC 126
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
465-710 |
1.33e-08 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 58.46 E-value: 1.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 465 PHCWRCRTPLIYRAVTSWYVKVTQIKERMLE-LNEEITWIPGNVKHgQFGTWVANA-RDWSISRNRYWGspIPVwesdhP 542
Cdd:pfam09334 167 PKCVICGTTPEVKETEHYFFDLSKFQDKLREwIEENNPEWPENVKN-MVLEWLKEGlKDRAISRDLDWG--IPV-----P 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 543 DFPRQEVYgslaeieeafgrlprnaqgevdlhrpwvddltrphpdpeaaaagavmrrvedvldVWFDSgSMPY-AQVHYP 621
Cdd:pfam09334 239 GAEGKVFY-------------------------------------------------------VWLDA-PIGYiSATKEL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 622 FERADWFPTH---NPADFIVEYIGQTRGWFYTMH---ILATALFDRPafSHVISHGIvLGSDGQKMSKSLRNYPDVTEVL 695
Cdd:pfam09334 263 SGNEEKWKEWwpnDPDTELVHFIGKDIIYFHTIFwpaMLLGAGYRLP--TTVFAHGY-LTYEGGKMSKSRGNVVWPSEAL 339
|
250
....*....|....*
gi 765340689 696 DRDGADAMRWFLMAS 710
Cdd:pfam09334 340 DRFPPDALRYYLARN 354
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
19-112 |
1.71e-07 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 55.44 E-value: 1.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 19 FPEIERRILAYWDEDGTFQASID-QRPTrnedgsqnefvFY--DGPPFANGLPHYGHLLtGYV-KDLVARYQTQQGRRVE 94
Cdd:COG0495 7 PKEIEKKWQKYWEENGTFKADEDsSKPK-----------YYvlDMFPYPSGRLHMGHVR-NYTiGDVVARYKRMQGYNVL 74
|
90
....*....|....*...
gi 765340689 95 RRFGWDTHGLPAELEAMK 112
Cdd:COG0495 75 HPMGWDAFGLPAENAAIK 92
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
62-203 |
2.02e-06 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 51.65 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 62 PFANGLPHYGHLLTGYVKDLVARYQTQQGRRVerRF--GWDTHGLPAELEAmkqlgmtdkseiEAMGIdtfndacrsSVL 139
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDV--LFvtGTDEHGTKIELAA------------EKEGI---------TPQ 66
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 765340689 140 KYTDQWQDYVTRQARWVDFEND--YKTLTPDFMESVIWAFSELHRKGLTYRGFRVLPYCWNDETPL 203
Cdd:COG0143 67 ELVDRIHAEFKELFEKLGISFDnfIRTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERFL 132
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
662-859 |
8.40e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 49.80 E-value: 8.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 662 PAFSHVISHGIVLgSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFLMaspilR----GGNLIVTEEGIREGVrqvllpaw 737
Cdd:PRK12267 282 PLPKKVFAHGWWL-MKDGKMSKSKGNVVDPEELVDRYGLDALRYYLL-----RevpfGSDGDFSPEALVERI-------- 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 738 NayhfftlyANTAHDGG-------ARPDGYRAQE--RHTAEDPLDQYILAATGRMLREVKTSLDAYEVSDATDALRGFMd 808
Cdd:PRK12267 348 N--------SDLANDLGnllnrtvAMINKYFDGEipAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKLI- 418
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 765340689 809 TLTNWYIrrsrerffDED---TVAFD---------VLYTVLEAFARAAA---PLMPLIAEEIWRGL 859
Cdd:PRK12267 419 SRANKYI--------DETapwVLAKDegkkerlatVMYHLAESLRKVAVllsPFMPETSKKIFEQL 476
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
61-221 |
9.71e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 49.50 E-value: 9.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 61 PPFANGLPHYGHLLTGYVKDLVARYQTQQGRRVerRF--GWDTHGLPAELEAmkqlgmtdkseiEAMGIDTFnDACRSSV 138
Cdd:PRK11893 9 IYYPNGKPHIGHAYTTLAADVLARFKRLRGYDV--FFltGTDEHGQKIQRKA------------EEAGISPQ-ELADRNS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 139 LKYTDQWQDYvtrqarwvDFENDY--KTLTPDFMESVIWAFSELHRKGLTYRGFRVLPYCWNDETPLSNHELRMDDDVYK 216
Cdd:PRK11893 74 AAFKRLWEAL--------NISYDDfiRTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDGYRCP 145
|
....*
gi 765340689 217 MRQDP 221
Cdd:PRK11893 146 PTGAP 150
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
758-857 |
4.09e-05 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 44.12 E-value: 4.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 758 DGYRAQERHTAEDPLDQYILAATGRMLREVKTSLDAYEVSDAT-DALRGFMDTLtNWYIRRSRERffdedtVAFDVLYTV 836
Cdd:cd07959 22 ELIETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALkEGLYELQNDL-DWYRERGGAG------MNKDLLRRF 94
|
90 100
....*....|....*....|.
gi 765340689 837 LEAFARAAAPLMPLIAEEIWR 857
Cdd:cd07959 95 IEVWTRLLAPFAPHLAEEIWH 115
|
|
| PksD |
COG3321 |
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
856-1138 |
1.81e-04 |
|
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 46.02 E-value: 1.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 856 WRGL---TGGRSVHLTDYP-------DADLFPHGPEADSLVARMDAVRRISSAGSALRKGAGRRVRLPLPRLSVVVPDAA 925
Cdd:COG3321 849 WSALypgRGRRRVPLPTYPfqredaaAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAA 928
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 926 GLEGTYARIVADELNLKDVELTELSEEAIARYGIGTELKLNFRELGKAFGRQVPLVKQAVDAGAYEETAEGLAVTLADGE 1005
Cdd:COG3321 929 LLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAA 1008
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 1006 TVTLAPALYELRTVSTGAPEGTAVGVLPGTAGFLVLDTEVSAELAAEGTARDVVRAVQAARKDAGLDVSDRVRTRIEGPT 1085
Cdd:COG3321 1009 ALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAA 1088
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 765340689 1086 AVVAALEAHRGLVAEETLTVDLELVDSGAADPRKDPADDAMKTVAVSVAKADA 1138
Cdd:COG3321 1089 ALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALA 1141
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
62-117 |
2.49e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 45.14 E-value: 2.49e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 765340689 62 PFANGLPHYGHLLTgYVK-DLVARYQTQQGRRVerRF--GWDTHGLPAELEAmKQLGMT 117
Cdd:PRK00133 11 PYANGPIHLGHLVE-YIQaDIWVRYQRMRGHEV--LFvcADDAHGTPIMLKA-EKEGIT 65
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
655-710 |
3.68e-04 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 42.95 E-value: 3.68e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 765340689 655 ATALFDRPaFSHVISHGIVLGSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFLMAS 710
Cdd:cd00672 150 SEAATGKP-FARYWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLALLSS 204
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
21-127 |
8.65e-04 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 43.52 E-value: 8.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 21 EIERRILAYWDEDGTFQASidqrPTRNEDGSQNEFvFYDGP-PFANGLPHYGHLLTGYVKDLVARYQTQQGRRVERRFGW 99
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFEAE----AGDEPPKPGEKF-FGNFPyPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAF 91
|
90 100
....*....|....*....|....*...
gi 765340689 100 DTHGLPAELEAMKQlgmtdKSEIEAMGI 127
Cdd:PLN02959 92 HCTGMPIKASADKL-----AREIQQYGN 114
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
656-708 |
1.86e-03 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 41.58 E-value: 1.86e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 765340689 656 TALFDRPAFSHVISHGIVLgSDGQKMSKSLRNYPDVTEVLDRDGADAMRWFLM 708
Cdd:pfam01406 230 EAAFDKQLANYWLHNGHVM-IDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLL 281
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
770-859 |
2.97e-03 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 39.01 E-value: 2.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 770 DPLDQYILAATGRMLREVKTSLDAYEVSDATDALRGFMDtLTNWYIRRSR--ERFFDEDTVAFD-VLYTVLEAFARAA-- 844
Cdd:cd07957 35 TEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELAR-AANKYIDETApwKLAKEEDPERLAtVLYVLLELLRILAil 113
|
90
....*....|....*.
gi 765340689 845 -APLMPLIAEEIWRGL 859
Cdd:cd07957 114 lSPFMPETAEKILDQL 129
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
677-769 |
3.35e-03 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 41.24 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340689 677 DGQKMSKSLRNYPDVTEVLDRDGADAMRWFLMA----SPIlrggNLivTEEGIREgvrqvllpAWNAYH-FFTLYANTAH 751
Cdd:COG0215 262 NGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLLSahyrSPL----DF--SEEALEE--------AEKALErLYNALRRLEE 327
|
90
....*....|....*...
gi 765340689 752 DGGARPDGYRAQERHTAE 769
Cdd:COG0215 328 ALGAADSSAEEIEELREE 345
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