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Conserved domains on  [gi|765340686|ref|WP_044659083|]
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MULTISPECIES: nucleoside-diphosphate kinase [Micrococcus]

Protein Classification

nucleoside-diphosphate kinase( domain architecture ID 10000602)

nucleoside-diphosphate kinase catalyzes the exchange of phosphate groups between different nucleoside diphosphates

CATH:  3.30.70.141
EC:  2.7.4.6
Gene Ontology:  GO:0006241|GO:0004550|GO:0046872|GO:0005524|GO:0006228|GO:0006183
SCOP:  4001261

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 4-139 2.38e-74

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


:

Pssm-ID: 439875  Cd Length: 140  Bit Score: 217.63  E-value: 2.38e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   4 QTEETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDS 83
Cdd:COG0105    1 AMERTLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGEN 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 765340686  84 VIEGFRSLAGKTDPTVAAPGTIRGDLGRDwgeaVQKNLVHGSDSTLSAERELAIWF 139
Cdd:COG0105   81 AVAVVRKLMGATNPAEAAPGTIRGDFALS----IGENAVHGSDSPESAEREIALFF 132
 
Name Accession Description Interval E-value
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 4-139 2.38e-74

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 217.63  E-value: 2.38e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   4 QTEETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDS 83
Cdd:COG0105    1 AMERTLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGEN 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 765340686  84 VIEGFRSLAGKTDPTVAAPGTIRGDLGRDwgeaVQKNLVHGSDSTLSAERELAIWF 139
Cdd:COG0105   81 AVAVVRKLMGATNPAEAAPGTIRGDFALS----IGENAVHGSDSPESAEREIALFF 132
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 6-139 1.61e-72

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 212.71  E-value: 1.61e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   6 EETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSVI 85
Cdd:cd04413    1 ERTLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 765340686  86 EGFRSLAGKTDPTVAAPGTIRGDLGRDwgeaVQKNLVHGSDSTLSAERELAIWF 139
Cdd:cd04413   81 KTVRKLMGATNPADAAPGTIRGDFALS----IGRNIVHGSDSVESAEREIALWF 130
NDK pfam00334
Nucleoside diphosphate kinase;
6-140 3.35e-72

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 211.96  E-value: 3.35e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686    6 EETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSVI 85
Cdd:pfam00334   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 765340686   86 EGFRSLAGKTDPTVAAPGTIRGDLGRDWGEavqkNLVHGSDSTLSAERELAIWFG 140
Cdd:pfam00334  81 SKWRELMGATNPAEAAPGTIRGDFAVSIGR----NAVHGSDSPESAEREIALFFP 131
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 5-139 2.20e-71

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 209.96  E-value: 2.20e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   5 TEETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSV 84
Cdd:PRK00668   1 MERTFSIIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 765340686  85 IEGFRSLAGKTDPTVAAPGTIRGDLgrdwGEAVQKNLVHGSDSTLSAERELAIWF 139
Cdd:PRK00668  81 IAKVRELMGATNPAEAAPGTIRGDF----ALSIGENVVHGSDSPESAAREIALFF 131
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 6-139 2.13e-67

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 200.08  E-value: 2.13e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686     6 EETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSVI 85
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 765340686    86 EGFRSLAGKTDPTVAAPGTIRGDLGRDwgeaVQKNLVHGSDSTLSAERELAIWF 139
Cdd:smart00562  81 KTWRTLMGPTDPREAAPGTIRGDFGLD----IGRNAVHGSDSPESAEREIALFF 130
 
Name Accession Description Interval E-value
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 4-139 2.38e-74

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 217.63  E-value: 2.38e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   4 QTEETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDS 83
Cdd:COG0105    1 AMERTLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGEN 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 765340686  84 VIEGFRSLAGKTDPTVAAPGTIRGDLGRDwgeaVQKNLVHGSDSTLSAERELAIWF 139
Cdd:COG0105   81 AVAVVRKLMGATNPAEAAPGTIRGDFALS----IGENAVHGSDSPESAEREIALFF 132
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 6-139 1.61e-72

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 212.71  E-value: 1.61e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   6 EETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSVI 85
Cdd:cd04413    1 ERTLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 765340686  86 EGFRSLAGKTDPTVAAPGTIRGDLGRDwgeaVQKNLVHGSDSTLSAERELAIWF 139
Cdd:cd04413   81 KTVRKLMGATNPADAAPGTIRGDFALS----IGRNIVHGSDSVESAEREIALWF 130
NDK pfam00334
Nucleoside diphosphate kinase;
6-140 3.35e-72

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 211.96  E-value: 3.35e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686    6 EETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSVI 85
Cdd:pfam00334   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 765340686   86 EGFRSLAGKTDPTVAAPGTIRGDLGRDWGEavqkNLVHGSDSTLSAERELAIWFG 140
Cdd:pfam00334  81 SKWRELMGATNPAEAAPGTIRGDFAVSIGR----NAVHGSDSPESAEREIALFFP 131
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 5-139 2.20e-71

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 209.96  E-value: 2.20e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   5 TEETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSV 84
Cdd:PRK00668   1 MERTFSIIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 765340686  85 IEGFRSLAGKTDPTVAAPGTIRGDLgrdwGEAVQKNLVHGSDSTLSAERELAIWF 139
Cdd:PRK00668  81 IAKVRELMGATNPAEAAPGTIRGDF----ALSIGENVVHGSDSPESAAREIALFF 131
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 6-139 2.13e-67

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 200.08  E-value: 2.13e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686     6 EETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSVI 85
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 765340686    86 EGFRSLAGKTDPTVAAPGTIRGDLGRDwgeaVQKNLVHGSDSTLSAERELAIWF 139
Cdd:smart00562  81 KTWRTLMGPTDPREAAPGTIRGDFGLD----IGRNAVHGSDSPESAEREIALFF 130
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 4-139 1.29e-59

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 181.07  E-value: 1.29e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   4 QTEETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDS 83
Cdd:PTZ00093   1 SSERTFIMVKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKN 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 765340686  84 VIEGFRSLAGKTDPTVAAPGTIRGDLGRDwgeaVQKNLVHGSDSTLSAERELAIWF 139
Cdd:PTZ00093  81 VVKQGRKLLGATNPLESAPGTIRGDFCVD----VGRNVIHGSDSVESAKREIALWF 132
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 6-139 1.09e-50

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 157.90  E-value: 1.09e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   6 EETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSVI 85
Cdd:cd00595    1 ERTLALIKPDAVAEGLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSGPVVAMILEKDNAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 765340686  86 EGFRSLAGKTDPTVA---APGTIRGDLGRDwgeaVQKNLVHGSDSTLSAERELAIWF 139
Cdd:cd00595   81 GEWREMLGPTNPEIArhlAPGSLRADFGTD----VLRNAVHGSDSVESAAREIAFFF 133
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 6-140 1.64e-47

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 149.59  E-value: 1.64e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   6 EETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSVI 85
Cdd:PRK14540   3 ERTFVALKPDAVERKLIGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKGKEFYERLINFMTSGRIVAMVIEGENAI 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 765340686  86 EGFRSLAGKTDPTVAAPGTIRGdlgrDWGEAVQKNLVHGSDSTLSAERELAIWFG 140
Cdd:PRK14540  83 STVRKMIGKTNPAEAEPGTIRG----DFGLYTPANIIHASDSKESAEREIKLFFG 133
PLN02619 PLN02619
nucleoside-diphosphate kinase
 4-139 1.85e-41

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 137.67  E-value: 1.85e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   4 QTEETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDS 83
Cdd:PLN02619  87 EMERTFIAIKPDGVQRGLISEIISRFERKGFKLVAIKVVVPSKEFAQKHYHDLKERPFFNGLCDFLSSGPVVAMVWEGEG 166

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 765340686  84 VIEGFRSLAGKTDPTVAAPGTIRGDLgrdwGEAVQKNLVHGSDSTLSAERELAIWF 139
Cdd:PLN02619 167 VIKYGRKLIGATDPQKSEPGTIRGDL----AVVVGRNIIHGSDGPETAKDEINLWF 218
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 6-140 7.71e-39

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 129.16  E-value: 7.71e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   6 EETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQ---------------------------- 57
Cdd:PRK14544   4 ERTLVILKPDAVKRGLVGEIISRFEKAGLKIVAMKMVKATPEQIERFYPSSEewyrsvgnkllkayqelgidprarlgtd 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686  58 -----GKPFFEPLVAFMASGPVVAARVTGDSVIEGFRSLAGKTDPTVAAPGTIRGD-------LGRDWGEAVqKNLVHGS 125
Cdd:PRK14544  84 dpvevGKKVKESLVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKAPPGTIRGDysidspdLAAEEGRVV-YNLVHAS 162

                        170
                 ....*....|....*
gi 765340686 126 DSTLSAERELAIWFG 140
Cdd:PRK14544 163 DSPEEAEREIKFWFR 177
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 6-139 1.15e-36

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 122.17  E-value: 1.15e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   6 EETLVLIKPDGVARnlVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSVI 85
Cdd:cd04415    1 EKTLALIKPDAYSK--IGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAI 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 765340686  86 EGFRSLAGKTDPTVA---APGTIRGDLGRDWgeavQKNLVHGSDSTLSAERELAIWF 139
Cdd:cd04415   79 SEWRKLLGPTNSSVArsdAPNSIRALFGTDG----TRNAAHGSDSVASAARELEFFF 131
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 6-139 1.04e-32

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 112.46  E-value: 1.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   6 EETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSVI 85
Cdd:PRK14542   2 SRTFIMIKPDGVKNKHVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNAV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 765340686  86 EGFRSLAGKTDPTVAAPGTIRGdlgrDWGEAVQKNLVHGSDSTLSAERELAIWF 139
Cdd:PRK14542  82 LHWREVIGATDPKEAAAGTIRA----LYAESKEANAVHGSDSDANAALEISFFF 131
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 6-139 1.37e-31

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 109.22  E-value: 1.37e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   6 EETLVLIKPDGVARNlVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSVI 85
Cdd:cd04416    1 EYTLALIKPDAVAEK-KDEILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEEEDYFEDLVEFMTSGPSLILVLSKENAV 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 765340686  86 EGFRSLAGKTDPTVA---APGTIRGDLGRDwgeaVQKNLVHGSDSTLSAERELAIWF 139
Cdd:cd04416   80 EEWRELMGPTDPEEAkeeKPDSLRAQFARD----HLSNAVHGSSSAEEAEKEIDFFF 132
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 5-139 1.02e-30

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 107.30  E-value: 1.02e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   5 TEETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSV 84
Cdd:PRK14545   3 GNRTFTMIKPDAVENGHIGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAERPFYGELVEFMSRGPIVAAILEKENA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 765340686  85 IEGFRSLAGKTDPTVAAPGTIRgdlgRDWGEAVQKNLVHGSDSTLSAERELAIWF 139
Cdd:PRK14545  83 VEDFRTLIGATNPADAAEGTIR----KKYAKSIGENAVHGSDSDENAQIEGAFHF 133
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 1-139 1.37e-30

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 107.67  E-value: 1.37e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   1 MTHQTEETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHY-----EEHQGKPFFEPLVAFMASGPVV 75
Cdd:PRK14543   1 MSTLIQKTLCIIKPDGVRRGLIGNVVSRFERVGLKIVAAKMLLVDRSMAEKHYlyddiAVRHGEAVWKSLIKFISSSPVF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686  76 AARVTGDSVIEGFRSLAGKTDPTVAAPGTIRGDLG-RDWGEAVQK-----NLVHGSDSTLSAERELAIWF 139
Cdd:PRK14543  81 VFVVEGVESVEVVRKFCGSTEPKLAIPGTIRGDFSyHSFNYANEKgfsvyNVIHASANEDDALREIPIWF 150
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 6-139 2.33e-29

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 103.63  E-value: 2.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   6 EETLVLIKPDGVARNLVGEILAR-IERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSV 84
Cdd:cd04414    1 QLTLALIKPDAVAHPLALEAVRQlILSNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 765340686  85 IEGFRSLAGKTDPTVA---APGTIRGDLGRDwgeaVQKNLVHGSDSTLSAERELAIWF 139
Cdd:cd04414   81 IKTWRALMGPTKVFRArasAPDSIRGLYGLT----DTRNATHGSDSPASAQREIALFF 134
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 6-139 2.94e-28

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 101.18  E-value: 2.94e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   6 EETLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSVI 85
Cdd:PRK14541   2 ERTLTILKPDCVRKQLIGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENAV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 765340686  86 EGFRSLAGKTDPTVAAPGTIRGDLGRDWGEavqkNLVHGSDSTLSAERELAIWF 139
Cdd:PRK14541  82 ADFRTLIGATDPAEAAEGTVRKLYADSKGE----NIVHGSDSAENAAIEAGFFF 131
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 6-139 1.88e-27

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 98.67  E-value: 1.88e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   6 EETLVLIKPDGVARNlvGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQGKPFFEPLVAFMASGPVVAARVTGDSVI 85
Cdd:cd04418    1 ERTLAIIKPDAVHKA--EEIEDIILESGFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPHLVAYMSSGPIVAMVLARHNAI 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 765340686  86 EGFRSLAGKTDPTVA---APGTIRGDLGRDwgeaVQKNLVHGSDSTLSAERELAIWF 139
Cdd:cd04418   79 SYWKELLGPTNSLKAketHPDSLRAIYGTD----DLRNAVHGSDSFSSAEREIRFMF 131
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 6-140 2.34e-27

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 99.90  E-value: 2.34e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   6 EETLVLIKPDGVARNLVGEILARIERKGYVIAD--LKMLTPTRAMLerHYEEHQGKPFFEPLVAFMASGPVVAARVTGDS 83
Cdd:PLN02931  30 ERTLAMIKPDGLSGNYTERIKEVILESGFSIVKemTTQLDEDRASL--FYAEHSSRSFFPSLVKYMTSGPVLVMVLEKEN 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686  84 VIEGFRSLAGKTDPTVAA---PGTIRGDLGRDwgeaVQKNLVHGSDSTLSAERELAIWFG 140
Cdd:PLN02931 108 AVSDWRTLIGPTDARKAKishPNSIRAMCGLD----SEKNCVHGSDSPESAEREISFFFG 163
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 8-139 1.80e-26

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 96.16  E-value: 1.80e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 765340686   8 TLVLIKPDGVARNLVGEILARIERKGYVIADLKMLTPTRAMLERHYEEHQG-KPFFEPLVAFMASGPVVAARVTGDSVIE 86
Cdd:cd04412    3 TVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGvVPELPAMVDELTSGPCIALEIAGENAVK 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 765340686  87 GFRSLAGKTDPTVA---APGTIRGDLGRDwgeAVQkNLVHGSDSTLSAERELAIWF 139
Cdd:cd04412   83 TFREFCGPFDPEIAkqlRPNTLRARYGKD---KVQ-NAVHCTDLPEDGPLELKFFF 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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